ArrestinDb

ArrestinDb (Arrestin database) offers:

  • Reference data (see Data box)
  • Analysis tools (browse menu)
  • Visualization (e.g., snakeplots)
  • Data deposition (for arrestin couplings and interface mutations)


Arrestins can 'arrest' signaling by blocking GPCR-mediated G protein coupling and inducing receptor internalization. They are also scaffold proteins rectruiting and assembling other signaling proteins and can be involved in biased signaling1

Data

  • Sequences
  • 4 Human arrestins
  • 90 Species orthologs
  • Couplings
  • 300 Arrestin couplings
  • Structures
  • 70 Arrestins
  • 458 Generic residues
  • 14 Arrestin complexes
  • Structure interactions
  • 376,338 Interface interactions
  • Mutations
  • 409 Interface mutations

Overview


Latest release

Dec. 20, 2024
  • GAIN domain segments for Class B2 (Adhesion) GPCRs
  • New structures
  • Minor bug and performance fixes

All releases

Related resources

GPCRdb, GproteinDb, ArrestinDb and Biased Signaling Atlas cover related aspects of signal transduction while serving dedicated research communities and use cases.