ArrestinDb

Excel (underlying datasets)

See the Datasets and Biosensors pages for more information about the underlying data.

Receptor						Source					Ligand		No. supporting datasets				Selectivity		Family rank orders				% of 1' G protein family				Quantitative values						% of 1' G protein subtype																Quantitative values
Uniprot	GtoPdb (IUPHAR)	GPCRdb	Rec. family	Cl	Other protein	Lab	Biosensor	Down- stream steps	#Gprots tested	Ref	Name	Phys. / Surr.	Gs	Gi/o	Gq/11	G12/13	Primary family	#Fam	Gs	Gi/o	Gq/11	G12/13	Gs	Gi/o	Gq/11	G12/13	Parameter	Gs	Gi/o	Gq/11	G12/13	Primary subtype	GsL	GsS	Golf	Gi1	Gi2	Gi3	Ggust	Gz	GoA	GoB	Gq	G11	G14	G15	G12	G13	Parameter	GsL	GsS	Golf	Gi1	Gi2	Gi3	Ggust	Gz	GoA	GoB	Gq	G11	G14	G15	G12	G13

5HT1A	5-HT_1A		5-Hydroxytryptamine	A	-	Bouvier	GEMTA	3	12		5-hydroxytryptamine	Phys	-	3	2	-	Gi/o	2	nc	1'	2'	nc	0	100	81	0	log(Emax/EC50)	0.0	8.3	6.7	0.0	GoB	0	-	-	92	85	-	-	96	97	100	0	0	65	81	0	0	log(Emax/EC50)	0.0	-	-	7.6	7.0	-	-	7.9	8.0	8.3	0.0	0.0	5.4	6.7	0.0	0.0
5HT1A	5-HT_1A		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	-	3	2	-	Gi/o	2	nc	1'	2'	nc	0	100	1	0	Activation rate (s^-1)	0.0	7.4	0.1	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	1	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	7.4	-	0.0	-	-	0.1	-	0.0
5HT1A	5-HT_1A		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	3	2	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT1A	5-HT_1A		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	2	-	Gi/o	2	nc	1'	2'	nc	0	100	41	0	-	-	-	-	-	GoB	0	-	-	92	85	-	-	96	98	100	0	0	65	41	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT1B	5-HT_1B		5-Hydroxytryptamine	A	-	Bouvier	GEMTA	3	12		5-hydroxytryptamine	Phys	-	3	1	-	Gi/o	2	nc	1'	2'	nc	0	100	71	0	log(Emax/EC50)	0.0	8.7	6.2	0.0	GoB	0	-	-	99	98	-	-	93	98	100	0	0	0	71	0	0	log(Emax/EC50)	0.0	-	-	8.6	8.6	-	-	8.1	8.5	8.7	0.0	0.0	0.0	6.2	0.0	0.0
5HT1B	5-HT_1B		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	-	3	1	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	0.4	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.4	-	0.0	-	-	0.0	-	0.0
5HT1B	5-HT_1B		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	3	1	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT1B	5-HT_1B		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	1	-	Gi/o	2	nc	1'	2'	nc	0	100	36	0	-	-	-	-	-	GoB	0	-	-	99	98	-	-	93	99	100	0	0	0	36	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT1D	5-HT_1D		5-Hydroxytryptamine	A	-	Bouvier	GEMTA	3	12		5-hydroxytryptamine	Phys	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	log(Emax/EC50)	0.0	8.6	0.0	0.0	Gi1	0	-	-	100	100	-	-	43	94	94	0	0	0	0	0	0	log(Emax/EC50)	0.0	-	-	8.6	8.6	-	-	3.7	8.1	8.1	0.0	0.0	0.0	0.0	0.0	0.0
5HT1D	5-HT_1D		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	0.2	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.2	-	0.0	-	-	0.0	-	0.0
5HT1D	5-HT_1D		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	3	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT1D	5-HT_1D		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	Gi1	0	-	-	100	100	-	-	43	97	94	0	0	0	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT1E	5-HT_1E		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	-	2	-	-	Gi/o	1	nc	1'	2'	nc	0	100	2	0	Activation rate (s^-1)	0.0	0.9	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	2	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.9	-	0.0	-	-	0.0	-	0.0
5HT1E	5-HT_1E		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT1E	5-HT_1E		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	-	Gi/o	2	nc	1'	2'	nc	0	100	2	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	2	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT1F	5-HT_1F		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	0.4	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.4	-	0.0	-	-	0.0	-	0.0
5HT1F	5-HT_1F		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT1F	5-HT_1F		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT2A	5-HT_2A		5-Hydroxytryptamine	A	-	Bouvier	GEMTA	3	12		5-hydroxytryptamine	Phys	-	3	5	-	Gq/11	2	nc	2'	1'	nc	0	77	100	0	log(Emax/EC50)	0.0	6.7	8.6	0.0	G14	0	-	-	68	63	-	-	77	62	66	98	99	100	93	0	0	log(Emax/EC50)	0.0	-	-	5.9	5.5	-	-	6.7	5.4	5.7	8.4	8.5	8.6	8.0	0.0	0.0
5HT2A	5-HT_2A		5-Hydroxytryptamine	A	-	Lambert	RGB-GDP	0	6	-	None (constitutive activity)	-	-	3	5	-	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	-	0.00	-
5HT2A	5-HT_2A		5-Hydroxytryptamine	A	-	Lambert	RGB-GDP	0	6	-	5-hydroxytryptamine	Phys	-	3	5	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	Efficacy	0.00	0.00	0.01	0.00	Gq	0	-	-	0	-	-	-	-	-	-	100	-	-	-	0	-	Efficacy	0.00	-	-	0.00	-	-	-	-	-	-	0.01	-	-	-	0.00	-
5HT2A	5-HT_2A		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	-	3	5	-	Gq/11	2	nc	2'	1'	nc	0	12	100	0	Activation rate (s^-1)	0.0	0.1	0.5	0.0	Gq	0	-	-	-	-	-	-	-	12	-	100	-	-	17	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.1	-	0.5	-	-	0.1	-	0.0
5HT2A	5-HT_2A		5-Hydroxytryptamine	A	-	Inoue	TGF𝛼	5	1		5-hydroxytryptamine	Phys	-	3	5	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.2	-	-	-	-	-
5HT2A	5-HT_2A		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	3	5	-	Gq/11	2	-	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT2A	5-HT_2A		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	5	-	Gq/11	2	nc	2'	1'	nc	0	22	75	0	-	-	-	-	-	G14	0	-	-	23	63	-	-	77	37	66	74	99	100	55	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT2B	5-HT_2B		5-Hydroxytryptamine	A	-	Bouvier	GEMTA	3	12		5-hydroxytryptamine	Phys	-	1	4	-	Gq/11	2	nc	2'	1'	nc	0	99	100	0	log(Emax/EC50)	0.0	7.7	7.8	0.0	Gq	0	-	-	0	0	-	-	99	0	85	100	100	97	90	0	0	log(Emax/EC50)	0.0	-	-	0.0	0.0	-	-	7.7	0.0	6.6	7.8	7.8	7.5	7.0	0.0	0.0
5HT2B	5-HT_2B		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	-	1	4	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	Activation rate (s^-1)	0.0	0.0	0.1	0.0	Gq	0	-	-	-	-	-	-	-	0	-	100	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.0	-	0.1	-	-	0.0	-	0.0
5HT2B	5-HT_2B		5-Hydroxytryptamine	A	-	Inoue	TGF𝛼	5	1		5-hydroxytryptamine	Phys	-	1	4	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.6	-	-	-	-	-
5HT2B	5-HT_2B		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	4	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT2B	5-HT_2B		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	4	-	Gq/11	2	nc	2'	1'	nc	0	50	100	0	-	-	-	-	-	Gq	0	-	-	0	0	-	-	99	0	85	100	100	97	45	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT2C	5-HT_2C		5-Hydroxytryptamine	A	-	Bouvier	GEMTA	3	12		5-hydroxytryptamine	Phys	-	3	4	1	Gi/o	3	nc	1'	2'	3'	0	100	97	84	log(Emax/EC50)	0.0	8.7	8.4	7.3	Gz	0	-	-	79	77	-	-	100	78	84	0	0	0	97	84	84	log(Emax/EC50)	0.0	-	-	6.9	6.7	-	-	8.7	6.8	7.3	0.0	0.0	0.0	8.4	7.3	7.3
5HT2C	5-HT_2C		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	-	3	4	1	Gq/11	2	nc	2'	1'	3'	0	1	100	0	Activation rate (s^-1)	0.0	0.1	10.3	0.0	Gq	0	-	-	-	-	-	-	-	1	-	100	-	-	1	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.1	-	10.3	-	-	0.1	-	0.0
5HT2C	5-HT_2C		5-Hydroxytryptamine	A	-	Inoue	TGF𝛼	5	1		5-hydroxytryptamine	Phys	-	3	4	1	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.4	-	-	-	-	-
5HT2C	5-HT_2C		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	3	4	1	Gq/11	2	-	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT2C	5-HT_2C		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	4	1	Gq/11	3	nc	2'	1'	3'	0	50	98	42	-	-	-	-	-	Gz	0	-	-	79	77	-	-	100	40	84	50	0	0	49	84	42	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT4R	5-HT₄		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	2	1	1	2	Gs	4	1'	3'	2'	4'	100	4	9	2	Activation rate (s^-1)	4.2	0.2	0.4	0.1	GsL	100	-	-	-	-	-	-	-	4	-	0	-	-	9	-	2	Activation rate (s^-1)	4.2	-	-	-	-	-	-	-	0.2	-	0.0	-	-	0.4	-	0.1
5HT4R	5-HT₄		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	2	1	1	2	Gs	2	1'	-	-	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT4R	5-HT₄		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	2	1	1	2	Gs	4	1'	3'	2'	4'	100	4	9	2	-	-	-	-	-	GsL	100	-	-	-	-	-	-	-	4	-	0	-	-	9	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT5A	5-HT_5A		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	-	2	1	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	0.1	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.1	-	0.0	-	-	0.0	-	0.0
5HT5A	5-HT_5A		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	1	-	Gi/o	2	-	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT5A	5-HT_5A		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	1	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT6R	5-HT₆		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	2	-	2	1	Gs	3	1'	nc	2'	3'	100	0	26	11	Activation rate (s^-1)	0.9	0.0	0.2	0.1	GsL	100	-	-	-	-	-	-	-	0	-	0	-	-	26	-	11	Activation rate (s^-1)	0.9	-	-	-	-	-	-	-	0.0	-	0.0	-	-	0.2	-	0.1
5HT6R	5-HT₆		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	2	-	2	1	Gs	2	1'	-	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT6R	5-HT₆		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	2	-	2	1	Gs	3	1'	nc	2'	3'	100	0	26	11	-	-	-	-	-	GsL	100	-	-	-	-	-	-	-	0	-	0	-	-	26	-	11	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT7R	5-HT₇		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	3	1	1	-	Gs	2	1'	2'	nc	nc	100	22	0	0	Activation rate (s^-1)	0.9	0.2	0.0	0.0	GsL	100	-	-	-	-	-	-	-	22	-	0	-	-	0	-	0	Activation rate (s^-1)	0.9	-	-	-	-	-	-	-	0.2	-	0.0	-	-	0.0	-	0.0
5HT7R	5-HT₇		5-Hydroxytryptamine	A	-	Roth	TRUPATH	1	15		5-hydroxytryptamine	Phys	3	1	1	-	Gs	1	1'	nc	nc	nc	100	0	0	0	log(Emax/EC50)	100.0	0.0	0.0	0.0	GsS	99	100	99	0	0	0	0	0	0	0	0	0	-	0	0	0	log(Emax/EC50)	7.8	7.9	7.8	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-	0.0	0.0	0.0
5HT7R	5-HT₇		5-Hydroxytryptamine	A	-	Inoue	TGF𝛼	5	1		5-hydroxytryptamine	Phys	3	1	1	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.8	-	-	-	-	-
5HT7R	5-HT₇		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	3	1	1	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT7R	5-HT₇		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	3	1	1	-	Gs	2	1'	2'	nc	nc	100	11	0	0	-	-	-	-	-	GsL	100	100	99	0	0	0	0	0	11	0	0	0	-	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ACM1	M₁		Acetylcholine (muscarinic)	A	-	Bouvier	GEMTA	3	12		acetylcholine	Phys	1	2	4	-	Gq/11	3	2'	3'	1'	nc	75	68	100	0	log(Emax/EC50)	5.8	5.3	7.8	0.0	G11	75	-	-	64	59	-	-	68	57	61	97	100	98	99	0	0	log(Emax/EC50)	5.8	-	-	4.9	4.6	-	-	5.3	4.4	4.8	7.5	7.8	7.6	7.6	0.0	0.0
ACM1	M₁		Acetylcholine (muscarinic)	A	-	Martemyanov	FreeGβγ-Nluc	2	5		acetylcholine	Phys	1	2	4	-	Gq/11	2	nc	2'	1'	nc	0	5	100	0	Activation rate (s^-1)	0.0	0.1	2.4	0.0	Gq	0	-	-	-	-	-	-	-	5	-	100	-	-	55	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.1	-	2.4	-	-	1.3	-	0.0
ACM1	M₁		Acetylcholine (muscarinic)	A	-	Inoue	TGF𝛼	5	1		acetylcholine	Phys	1	2	4	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.5	-	-	-	-	-
ACM1	M₁		Acetylcholine (muscarinic)	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	2	4	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ACM1	M₁		Acetylcholine (muscarinic)	A	-	GproteinDb	merged data	-	-	-	-	-	1	2	4	-	Gq/11	3	2'	3'	1'	nc	38	36	100	0	-	-	-	-	-	G11	38	-	-	64	59	-	-	68	31	61	98	100	98	77	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ACM2	M₂		Acetylcholine (muscarinic)	A	-	Bouvier	GEMTA	3	12		acetylcholine	Phys	2	3	2	-	Gi/o	3	3'	1'	2'	nc	65	100	86	0	log(Emax/EC50)	5.6	8.6	7.4	0.0	GoB	65	-	-	92	88	-	-	92	94	100	0	0	52	86	0	0	log(Emax/EC50)	5.6	-	-	7.9	7.6	-	-	8.0	8.1	8.6	0.0	0.0	4.5	7.4	0.0	0.0
ACM2	M₂		Acetylcholine (muscarinic)	A	-	Martemyanov	FreeGβγ-Nluc	2	5		acetylcholine	Phys	2	3	2	-	Gi/o	1	nc	1'	2'	nc	0	100	2	0	Activation rate (s^-1)	0.0	1.3	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	2	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	1.3	-	0.0	-	-	0.0	-	0.0
ACM2	M₂		Acetylcholine (muscarinic)	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	2	3	2	-	Gi/o	3	2'	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ACM2	M₂		Acetylcholine (muscarinic)	A	-	GproteinDb	merged data	-	-	-	-	-	2	3	2	-	Gi/o	3	3'	1'	2'	nc	32	100	44	0	-	-	-	-	-	GoB	32	-	-	92	88	-	-	92	97	100	0	0	52	44	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DRD2	D₂		Dopamine	A	-	Bouvier	GEMTA	3	12		dopamine	Phys	1	5	2	-	Gi/o	2	nc	1'	2'	nc	0	100	61	0	log(Emax/EC50)	0.0	8.6	5.3	0.0	GoB	0	-	-	93	87	-	-	86	93	100	0	0	0	61	0	0	log(Emax/EC50)	0.0	-	-	8.0	7.5	-	-	7.4	8.0	8.6	0.0	0.0	0.0	5.3	0.0	0.0
DRD2	D₂		Dopamine	A	-	Lambert	RGB-GDP	0	6		dopamine	Phys	1	5	2	-	Gi/o	3	3'	1'	2'	nc	7	100	8	0	Efficacy	0.01	0.14	0.01	0.00	Gi1	7	-	-	100	-	-	-	-	-	-	8	-	-	-	0	-	Efficacy	0.01	-	-	0.14	-	-	-	-	-	-	0.01	-	-	-	0.00	-
DRD2	D₂		Dopamine	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	1	5	2	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Econstitutive	0.00	0.03	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.03	-	-	-	-	-	-	0.00	-	-	-	0.00	-
DRD2	D₂		Dopamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		dopamine	Phys	1	5	2	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	4.2	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	4.2	-	0.0	-	-	0.0	-	0.0
DRD2	D₂		Dopamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	5	2	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DRD2	D₂		Dopamine	A	-	GproteinDb	merged data	-	-	-	-	-	1	5	2	-	Gi/o	3	3'	1'	2'	nc	2	100	17	0	-	-	-	-	-	GoB	2	-	-	98	87	-	-	86	96	100	2	0	0	30	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ACM3	M₃		Acetylcholine (muscarinic)	A	-	Bouvier	GEMTA	3	12		acetylcholine	Phys	1	3	6	-	Gq/11	2	nc	2'	1'	nc	0	72	100	0	log(Emax/EC50)	0.0	5.4	7.6	0.0	G15	0	-	-	72	65	-	-	67	67	69	94	97	97	100	0	0	log(Emax/EC50)	0.0	-	-	5.4	4.9	-	-	5.1	5.0	5.2	7.1	7.4	7.3	7.6	0.0	0.0
ACM3	M₃		Acetylcholine (muscarinic)	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	1	3	6	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	Econstitutive	0.00	0.00	0.02	0.00	Gq	0	-	-	0	-	-	-	-	-	-	100	-	-	-	0	-	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.02	-	-	-	0.00	-
ACM3	M₃		Acetylcholine (muscarinic)	A	-	Lambert	RGB-GDP	0	6		acetylcholine	Phys	1	3	6	-	Gq/11	3	3'	2'	1'	nc	15	67	100	0	Efficacy	0.02	0.09	0.13	0.00	Gq	15	-	-	67	-	-	-	-	-	-	100	-	-	-	0	-	Efficacy	0.02	-	-	0.09	-	-	-	-	-	-	0.13	-	-	-	0.00	-
ACM3	M₃		Acetylcholine (muscarinic)	A	-	Martemyanov	FreeGβγ-Nluc	2	5		acetylcholine	Phys	1	3	6	-	Gq/11	2	nc	2'	1'	nc	0	13	100	0	Activation rate (s^-1)	0.0	0.6	5.0	0.0	Gq	0	-	-	-	-	-	-	-	13	-	100	-	-	49	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.6	-	5.0	-	-	2.5	-	0.0
ACM3	M₃		Acetylcholine (muscarinic)	A	-	Inoue	TGF𝛼	5	1		acetylcholine	Phys	1	3	6	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.1	-	-	-	-	-
ACM3	M₃		Acetylcholine (muscarinic)	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	3	6	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ACM3	M₃		Acetylcholine (muscarinic)	A	-	GproteinDb	merged data	-	-	-	-	-	1	3	6	-	Gq/11	3	3'	2'	1'	nc	4	38	100	0	-	-	-	-	-	Gq	4	-	-	46	65	-	-	67	40	69	98	97	97	74	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ACM4	M₄		Acetylcholine (muscarinic)	A	-	Bouvier	GEMTA	3	12		acetylcholine	Phys	1	5	3	1	Gi/o	2	nc	1'	2'	nc	0	100	78	0	log(Emax/EC50)	0.0	8.7	6.9	0.0	GoB	0	-	-	93	94	-	-	90	92	100	52	0	56	78	0	0	log(Emax/EC50)	0.0	-	-	8.1	8.2	-	-	7.9	8.0	8.7	4.6	0.0	4.9	6.9	0.0	0.0
ACM4	M₄		Acetylcholine (muscarinic)	A	-	Lambert	RGB-GDP	0	6		acetylcholine	Phys	1	5	3	1	Gi/o	4	2'	1'	4'	3'	16	100	9	11	Efficacy	0.06	0.39	0.04	0.04	Gi1	16	-	-	100	-	-	-	-	-	-	9	-	-	-	11	-	Efficacy	0.06	-	-	0.39	-	-	-	-	-	-	0.04	-	-	-	0.04	-
ACM4	M₄		Acetylcholine (muscarinic)	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	1	5	3	1	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Econstitutive	0.00	0.14	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.14	-	-	-	-	-	-	0.00	-	-	-	0.00	-
ACM4	M₄		Acetylcholine (muscarinic)	A	-	Martemyanov	FreeGβγ-Nluc	2	5		acetylcholine	Phys	1	5	3	1	Gi/o	2	nc	1'	2'	nc	0	100	3	0	Activation rate (s^-1)	0.0	5.8	0.2	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	3	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	5.8	-	0.0	-	-	0.2	-	0.0
ACM4	M₄		Acetylcholine (muscarinic)	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	5	3	1	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ACM4	M₄		Acetylcholine (muscarinic)	A	-	GproteinDb	merged data	-	-	-	-	-	1	5	3	1	Gi/o	4	3'	1'	2'	4'	4	100	22	3	-	-	-	-	-	GoB	4	-	-	98	94	-	-	90	96	100	15	0	56	40	4	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ACM5	M₅		Acetylcholine (muscarinic)	A	-	Martemyanov	FreeGβγ-Nluc	2	5		acetylcholine	Phys	-	1	3	-	Gq/11	2	nc	2'	1'	nc	0	6	100	0	Activation rate (s^-1)	0.0	0.2	2.8	0.0	Gq	0	-	-	-	-	-	-	-	6	-	100	-	-	53	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.2	-	2.8	-	-	1.5	-	0.0
ACM5	M₅		Acetylcholine (muscarinic)	A	-	Inoue	TGF𝛼	5	1		acetylcholine	Phys	-	1	3	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.1	-	-	-	-	-
ACM5	M₅		Acetylcholine (muscarinic)	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	3	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ACM5	M₅		Acetylcholine (muscarinic)	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	3	-	Gq/11	2	nc	2'	1'	nc	0	6	100	0	-	-	-	-	-	Gq	0	-	-	-	-	-	-	-	6	-	100	-	-	53	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA1A	α_1A		Adrenoceptors	A	-	Bouvier	GEMTA	3	12		noradrenaline	Phys	2	1	4	1	Gq/11	3	2'	3'	1'	nc	85	78	100	0	log(Emax/EC50)	6.6	6.1	7.8	0.0	G15	85	-	-	76	0	-	-	0	78	0	97	97	85	100	0	0	log(Emax/EC50)	6.6	-	-	5.9	0.0	-	-	0.0	6.1	0.0	7.6	7.5	6.6	7.8	0.0	0.0
ADA1A	α_1A		Adrenoceptors	A	-	Martemyanov	FreeGβγ-Nluc	2	5		(±)-adrenaline	Phys	2	1	4	1	Gq/11	2	2'	nc	1'	nc	21	0	100	0	Activation rate (s^-1)	0.3	0.0	1.3	0.0	Gq	21	-	-	-	-	-	-	-	0	-	100	-	-	29	-	0	Activation rate (s^-1)	0.3	-	-	-	-	-	-	-	0.0	-	1.3	-	-	0.4	-	0.0
ADA1A	α_1A		Adrenoceptors	A	-	Inoue	TGF𝛼	5	1		(-)-noradrenaline	Phys	2	1	4	1	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.0	-	-	-	-	-
ADA1A	α_1A		Adrenoceptors	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	2	1	4	1	Gq/11	2	-	-	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA1A	α_1A		Adrenoceptors	A	-	GproteinDb	merged data	-	-	-	-	-	2	1	4	1	Gq/11	3	2'	3'	1'	nc	53	39	100	0	-	-	-	-	-	Gq	53	-	-	76	0	-	-	0	39	0	98	97	85	64	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA1B	α_1B		Adrenoceptors	A	-	Martemyanov	FreeGβγ-Nluc	2	5		(±)-adrenaline	Phys	-	-	3	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	Activation rate (s^-1)	0.0	0.0	0.5	0.0	G15	0	-	-	-	-	-	-	-	0	-	88	-	-	100	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.0	-	0.4	-	-	0.5	-	0.0
ADA1B	α_1B		Adrenoceptors	A	-	Inoue	TGF𝛼	5	1		(-)-noradrenaline	Phys	-	-	3	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.1	-	-	-	-	-
ADA1B	α_1B		Adrenoceptors	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	-	3	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA1B	α_1B		Adrenoceptors	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	3	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	-	-	-	-	-	G15	0	-	-	-	-	-	-	-	0	-	88	-	-	100	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA1D	α_1D		Adrenoceptors	A	-	Martemyanov	FreeGβγ-Nluc	2	5		(±)-adrenaline	Phys	-	-	2	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	Activation rate (s^-1)	0.0	0.0	0.2	0.0	Gq	0	-	-	-	-	-	-	-	0	-	100	-	-	25	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.0	-	0.2	-	-	0.1	-	0.0
ADA1D	α_1D		Adrenoceptors	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	-	2	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA1D	α_1D		Adrenoceptors	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	2	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	-	-	-	-	-	Gq	0	-	-	-	-	-	-	-	0	-	100	-	-	25	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA2A	α_2A		Adrenoceptors	A	-	Bouvier	GEMTA	3	12		noradrenaline	Phys	2	5	1	1	Gi/o	4	4'	1'	2'	3'	58	100	68	60	log(Emax/EC50)	5.3	9.1	6.2	5.5	Gz	58	-	-	93	91	-	-	100	91	96	50	49	49	68	57	60	log(Emax/EC50)	5.3	-	-	8.5	8.3	-	-	9.1	8.3	8.8	4.6	4.4	4.4	6.2	5.2	5.5
ADA2A	α_2A		Adrenoceptors	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	2	5	1	1	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Econstitutive	0.00	0.03	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.03	-	-	-	-	-	-	0.00	-	-	-	0.00	-
ADA2A	α_2A		Adrenoceptors	A	-	Lambert	RGB-GDP	0	6		noradrenaline	Phys	2	5	1	1	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Efficacy	0.00	0.10	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Efficacy	0.00	-	-	0.10	-	-	-	-	-	-	0.00	-	-	-	0.00	-
ADA2A	α_2A		Adrenoceptors	A	-	Martemyanov	FreeGβγ-Nluc	2	5		(±)-adrenaline	Phys	2	5	1	1	Gi/o	1	nc	1'	2'	nc	0	100	0	0	Activation rate (s^-1)	0.0	10.8	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	10.8	-	0.0	-	-	0.0	-	0.0
ADA2A	α_2A		Adrenoceptors	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	2	5	1	1	Gi/o	2	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA2A	α_2A		Adrenoceptors	A	-	GproteinDb	merged data	-	-	-	-	-	2	5	1	1	Gi/o	4	4'	1'	2'	3'	14	100	17	15	-	-	-	-	-	Gz	14	-	-	98	91	-	-	100	96	96	12	49	49	34	19	30	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA2B	α_2B		Adrenoceptors	A	-	Bouvier	GEMTA	3	12		noradrenaline	Phys	1	3	1	-	Gi/o	2	nc	1'	2'	nc	0	100	72	0	log(Emax/EC50)	0.0	8.2	5.9	0.0	Gz	0	-	-	92	87	-	-	100	93	99	0	0	0	72	0	0	log(Emax/EC50)	0.0	-	-	7.5	7.1	-	-	8.2	7.6	8.1	0.0	0.0	0.0	5.9	0.0	0.0
ADA2B	α_2B		Adrenoceptors	A	-	Martemyanov	FreeGβγ-Nluc	2	5		(±)-adrenaline	Phys	1	3	1	-	Gi/o	1	nc	1'	2'	nc	0	100	1	0	Activation rate (s^-1)	0.0	1.7	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	1	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	1.7	-	0.0	-	-	0.0	-	0.0
ADA2B	α_2B		Adrenoceptors	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	3	1	-	Gi/o	2	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA2B	α_2B		Adrenoceptors	A	-	GproteinDb	merged data	-	-	-	-	-	1	3	1	-	Gi/o	2	nc	1'	2'	nc	0	100	36	0	-	-	-	-	-	Gz	0	-	-	92	87	-	-	100	96	99	0	0	0	36	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA2C	α_2C		Adrenoceptors	A	-	Bouvier	GEMTA	3	12		noradrenaline	Phys	1	3	1	1	Gi/o	3	nc	1'	3'	2'	0	100	55	55	log(Emax/EC50)	0.0	9.5	5.2	5.3	Gz	0	-	-	90	88	-	-	100	93	98	0	0	0	55	0	55	log(Emax/EC50)	0.0	-	-	8.5	8.4	-	-	9.5	8.9	9.4	0.0	0.0	0.0	5.2	0.0	5.3
ADA2C	α_2C		Adrenoceptors	A	-	Martemyanov	FreeGβγ-Nluc	2	5		(±)-adrenaline	Phys	1	3	1	1	Gi/o	1	nc	1'	2'	nc	0	100	0	0	Activation rate (s^-1)	0.0	9.1	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	9.1	-	0.0	-	-	0.0	-	0.0
ADA2C	α_2C		Adrenoceptors	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	3	1	1	Gi/o	2	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA2C	α_2C		Adrenoceptors	A	-	GproteinDb	merged data	-	-	-	-	-	1	3	1	1	Gi/o	3	nc	1'	2'	3'	0	100	28	28	-	-	-	-	-	Gz	0	-	-	90	88	-	-	100	96	98	0	0	0	28	0	28	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADRB1	β₁		Adrenoceptors	A	-	Bouvier	GEMTA	3	12		noradrenaline	Phys	3	3	2	1	Gs	4	1'	3'	2'	4'	100	64	85	57	log(Emax/EC50)	9.6	6.1	8.2	5.5	GsL	100	-	-	0	0	-	-	64	56	60	48	0	56	85	57	54	log(Emax/EC50)	9.6	-	-	0.0	0.0	-	-	6.1	5.4	5.8	4.6	0.0	5.4	8.2	5.5	5.2
ADRB1	β₁		Adrenoceptors	A	-	Martemyanov	FreeGβγ-Nluc	2	5		(±)-adrenaline	Phys	3	3	2	1	Gs	3	1'	3'	2'	nc	100	6	34	0	Activation rate (s^-1)	2.9	0.2	1.0	0.0	GsL	100	-	-	-	-	-	-	-	6	-	0	-	-	34	-	0	Activation rate (s^-1)	2.9	-	-	-	-	-	-	-	0.2	-	0.0	-	-	1.0	-	0.0
ADRB1	β₁		Adrenoceptors	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	3	3	2	1	Gs	2	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADRB1	β₁		Adrenoceptors	A	-	GproteinDb	merged data	-	-	-	-	-	3	3	2	1	Gs	4	1'	3'	2'	4'	100	35	60	28	-	-	-	-	-	GsL	100	-	-	0	0	-	-	64	31	60	24	0	56	60	57	27	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADRB2	β₂		Adrenoceptors	A	-	Bouvier	GEMTA	3	12		noradrenaline	Phys	6	3	4	-	Gs	2	1'	nc	2'	nc	100	0	77	0	log(Emax/EC50)	8.2	0.0	6.3	0.0	GsL	100	-	-	0	0	-	-	0	0	0	0	0	0	77	0	0	log(Emax/EC50)	8.2	-	-	0.0	0.0	-	-	0.0	0.0	0.0	0.0	0.0	0.0	6.3	0.0	0.0
ADRB2	β₂		Adrenoceptors	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	6	3	4	-	Gs	1	1'	nc	nc	nc	100	0	0	0	Econstitutive	0.02	0.00	0.00	0.00	GsL	100	-	-	0	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.02	-	-	0.00	-	-	-	-	-	-	0.00	-	-	-	0.00	-
ADRB2	β₂		Adrenoceptors	A	-	Lambert	RGB-GDP	0	6		noradrenaline	Phys	6	3	4	-	Gs	3	1'	2'	3'	nc	100	56	25	0	Efficacy	0.09	0.05	0.02	0.00	GsL	100	-	-	56	-	-	-	-	-	-	25	-	-	-	0	-	Efficacy	0.09	-	-	0.05	-	-	-	-	-	-	0.02	-	-	-	0.00	-
ADRB2	β₂		Adrenoceptors	A	-	Martemyanov	FreeGβγ-Nluc	2	5		(±)-adrenaline	Phys	6	3	4	-	Gs	2	1'	nc	2'	nc	100	0	11	0	Activation rate (s^-1)	2.1	0.0	0.2	0.0	GsL	100	-	-	-	-	-	-	-	0	-	0	-	-	11	-	0	Activation rate (s^-1)	2.1	-	-	-	-	-	-	-	0.0	-	0.0	-	-	0.2	-	0.0
ADRB2	β₂		Adrenoceptors	A	-	Roth	TRUPATH	1	15		(-)-adrenaline	Phys	6	3	4	-	Gs	3	1'	3'	2'	nc	100	8	11	0	log(Emax/EC50)	79.8	6.6	8.5	0.0	G15	80	76	80	0	78	0	0	64	64	70	0	0	-	100	0	0	log(Emax/EC50)	6.8	6.4	6.8	0.0	6.6	0.0	0.0	5.4	5.4	6.0	0.0	0.0	-	8.5	0.0	0.0
ADRB2	β₂		Adrenoceptors	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	6	3	4	-	Gs	2	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADRB2	β₂		Adrenoceptors	A	-	GproteinDb	merged data	-	-	-	-	-	6	3	4	-	Gs	3	1'	3'	2'	nc	100	13	25	0	-	-	-	-	-	GsL	96	76	80	14	39	0	0	32	21	35	5	0	0	63	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADRB3	β₃		Adrenoceptors	A	-	Martemyanov	FreeGβγ-Nluc	2	5		(±)-adrenaline	Phys	2	1	1	-	Gs	2	1'	nc	2'	nc	100	0	18	0	Activation rate (s^-1)	0.5	0.0	0.1	0.0	GsL	100	-	-	-	-	-	-	-	0	-	0	-	-	18	-	0	Activation rate (s^-1)	0.5	-	-	-	-	-	-	-	0.0	-	0.0	-	-	0.1	-	0.0
ADRB3	β₃		Adrenoceptors	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	2	1	1	-	Gs	2	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADRB3	β₃		Adrenoceptors	A	-	GproteinDb	merged data	-	-	-	-	-	2	1	1	-	Gs	2	1'	nc	2'	nc	100	0	18	0	-	-	-	-	-	GsL	100	-	-	-	-	-	-	-	0	-	0	-	-	18	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DRD1	D₁		Dopamine	A	-	Bouvier	GEMTA	3	12		dopamine	Phys	5	2	2	-	Gs	3	1'	3'	2'	nc	100	61	86	0	log(Emax/EC50)	8.6	5.3	7.4	0.0	GsL	100	-	-	0	0	-	-	61	0	56	0	0	0	86	0	0	log(Emax/EC50)	8.6	-	-	0.0	0.0	-	-	5.3	0.0	4.8	0.0	0.0	0.0	7.4	0.0	0.0
DRD1	D₁		Dopamine	A	-	Lambert	RGB-GDP	0	6		dopamine	Phys	5	2	2	-	Gs	2	1'	2'	nc	nc	100	71	0	0	Efficacy	0.05	0.04	0.00	0.00	GsL	100	-	-	71	-	-	-	-	-	-	0	-	-	-	0	-	Efficacy	0.05	-	-	0.04	-	-	-	-	-	-	0.00	-	-	-	0.00	-
DRD1	D₁		Dopamine	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	5	2	2	-	Gs	1	1'	nc	nc	nc	100	0	0	0	Econstitutive	0.03	0.00	0.00	0.00	GsL	100	-	-	0	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.03	-	-	0.00	-	-	-	-	-	-	0.00	-	-	-	0.00	-
DRD1	D₁		Dopamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		dopamine	Phys	5	2	2	-	Gs	2	1'	nc	2'	nc	100	0	18	0	Activation rate (s^-1)	1.1	0.0	0.2	0.0	GsL	100	-	-	-	-	-	-	-	0	-	0	-	-	18	-	0	Activation rate (s^-1)	1.1	-	-	-	-	-	-	-	0.0	-	0.0	-	-	0.2	-	0.0
DRD1	D₁		Dopamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	5	2	2	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DRD1	D₁		Dopamine	A	-	GproteinDb	merged data	-	-	-	-	-	5	2	2	-	Gs	3	1'	2'	3'	nc	100	33	26	0	-	-	-	-	-	GsL	100	-	-	24	0	-	-	61	0	56	0	0	0	52	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DRD3	D₃		Dopamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		dopamine	Phys	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	0.3	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.3	-	0.0	-	-	0.0	-	0.0
DRD3	D₃		Dopamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DRD3	D₃		Dopamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DRD4	D₄		Dopamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		dopamine	Phys	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	3.9	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	3.9	-	0.0	-	-	0.0	-	0.0
DRD4	D₄		Dopamine	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DRD4	D₄		Dopamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DRD5	D₅		Dopamine	A	-	Bouvier	GEMTA	3	12		dopamine	Phys	4	3	2	-	Gs	3	1'	3'	2'	nc	100	70	91	0	log(Emax/EC50)	8.4	5.9	7.7	0.0	GsL	100	-	-	60	55	-	-	0	0	70	0	0	0	91	0	0	log(Emax/EC50)	8.4	-	-	5.1	4.6	-	-	0.0	0.0	5.9	0.0	0.0	0.0	7.7	0.0	0.0
DRD5	D₅		Dopamine	A	-	Lambert	RGB-GDP	0	6	-	dopamine	Phys	4	3	2	-	Gs	2	1'	2'	nc	nc	100	65	0	0	Efficacy	0.02	0.02	0.00	0.00	GsL	100	-	-	65	-	-	-	-	-	-	0	-	-	-	0	-	Efficacy	0.02	-	-	0.02	-	-	-	-	-	-	0.00	-	-	-	0.00	-
DRD5	D₅		Dopamine	A	-	Lambert	RGB-GDP	0	6	-	None (constitutive activity)	-	4	3	2	-	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	-	0.00	-
DRD5	D₅		Dopamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		dopamine	Phys	4	3	2	-	Gs	3	1'	3'	2'	nc	100	14	41	0	Activation rate (s^-1)	1.6	0.2	0.6	0.0	GsL	100	-	-	-	-	-	-	-	14	-	0	-	-	41	-	0	Activation rate (s^-1)	1.6	-	-	-	-	-	-	-	0.2	-	0.0	-	-	0.6	-	0.0
DRD5	D₅		Dopamine	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	4	3	2	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DRD5	D₅		Dopamine	A	-	GproteinDb	merged data	-	-	-	-	-	4	3	2	-	Gs	3	1'	2'	3'	nc	75	37	33	0	-	-	-	-	-	GsL	75	-	-	42	55	-	-	0	7	70	0	0	0	66	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HRH1	H₁		Histamine	A	-	Bouvier	GEMTA	3	12		histamine	Phys	2	3	6	2	Gq/11	4	4'	2'	1'	3'	68	83	100	71	log(Emax/EC50)	5.5	6.8	8.1	5.8	G15	68	-	-	79	75	-	-	83	73	75	92	95	95	100	71	67	log(Emax/EC50)	5.5	-	-	6.4	6.1	-	-	6.8	6.0	6.1	7.5	7.7	7.8	8.1	5.8	5.5
HRH1	H₁		Histamine	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	2	3	6	2	Gq/11	1	nc	nc	1'	nc	0	0	100	0	Econstitutive	0.00	0.00	0.01	0.00	Gq	0	-	-	0	-	-	-	-	-	-	100	-	-	-	0	-	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.01	-	-	-	0.00	-
HRH1	H₁		Histamine	A	-	Lambert	RGB-GDP	0	6		histamine	Phys	2	3	6	2	Gq/11	3	3'	2'	1'	nc	28	96	100	0	Efficacy	0.02	0.07	0.08	0.00	Gq	28	-	-	96	-	-	-	-	-	-	100	-	-	-	0	-	Efficacy	0.02	-	-	0.07	-	-	-	-	-	-	0.08	-	-	-	0.00	-
HRH1	H₁		Histamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		histamine	Phys	2	3	6	2	Gq/11	3	nc	2'	1'	3'	0	30	100	12	Activation rate (s^-1)	0.0	0.4	1.3	0.1	Gq	0	-	-	-	-	-	-	-	30	-	100	-	-	46	-	12	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.4	-	1.3	-	-	0.6	-	0.1
HRH1	H₁		Histamine	A	-	Inoue	TGF𝛼	5	1		histamine	Phys	2	3	6	2	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.2	-	-	-	-	-
HRH1	H₁		Histamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	2	3	6	2	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HRH1	H₁		Histamine	A	-	GproteinDb	merged data	-	-	-	-	-	2	3	6	2	Gq/11	4	3'	2'	1'	4'	24	52	100	21	-	-	-	-	-	Gq	24	-	-	58	75	-	-	83	52	75	98	95	95	73	24	40	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HRH2	H₂		Histamine	A	-	Bouvier	GEMTA	3	12		histamine	Phys	5	2	4	1	Gs	4	1'	4'	2'	3'	100	58	93	63	log(Emax/EC50)	7.0	4.1	6.5	4.4	GsL	100	-	-	0	0	-	-	46	58	58	0	0	0	93	58	63	log(Emax/EC50)	7.0	-	-	0.0	0.0	-	-	3.2	4.0	4.1	0.0	0.0	0.0	6.5	4.0	4.4
HRH2	H₂		Histamine	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	5	2	4	1	Gs	1	1'	nc	nc	nc	100	0	0	0	Econstitutive	0.07	0.00	0.00	0.00	GsL	100	-	-	0	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.07	-	-	0.00	-	-	-	-	-	-	0.00	-	-	-	0.00	-
HRH2	H₂		Histamine	A	-	Lambert	RGB-GDP	0	6		amthamine	Surr	5	2	4	1	Gs	3	1'	2'	3'	nc	100	24	20	0	Efficacy	0.08	0.02	0.02	0.00	GsL	100	-	-	24	-	-	-	-	-	-	20	-	-	-	0	-	Efficacy	0.08	-	-	0.02	-	-	-	-	-	-	0.02	-	-	-	0.00	-
HRH2	H₂		Histamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		histamine	Phys	5	2	4	1	Gs	2	1'	nc	2'	nc	100	0	33	0	Activation rate (s^-1)	1.6	0.0	0.5	0.0	GsL	100	-	-	-	-	-	-	-	0	-	0	-	-	33	-	0	Activation rate (s^-1)	1.6	-	-	-	-	-	-	-	0.0	-	0.0	-	-	0.5	-	0.0
HRH2	H₂		Histamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	5	2	4	1	Gq/11	2	2'	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HRH2	H₂		Histamine	A	-	GproteinDb	merged data	-	-	-	-	-	5	2	4	1	Gs	4	1'	3'	2'	4'	100	20	36	16	-	-	-	-	-	GsL	100	-	-	8	0	-	-	46	29	58	5	0	0	63	19	32	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HRH3	H₃		Histamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		histamine	Phys	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	2.3	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	2.3	-	0.0	-	-	0.0	-	0.0
HRH3	H₃		Histamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HRH3	H₃		Histamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HRH4	H₄		Histamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HRH4	H₄		Histamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TAAR1	TA₁		Trace amine	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	-	1	-	Gs	2	1'	-	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TAAR1	TA₁		Trace amine	A	-	GproteinDb	merged data	-	-	-	-	-	1	-	1	-	Gs	2	1'	-	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AGTR1	AT₁		Angiotensin	A	-	Bouvier	GEMTA	3	12		angiotensin II	Phys	-	3	4	1	Gq/11	3	nc	3'	1'	2'	0	79	100	96	log(Emax/EC50)	0.0	7.1	9.0	8.6	G11	0	-	-	77	76	-	-	71	79	77	97	100	91	92	93	96	log(Emax/EC50)	0.0	-	-	6.9	6.8	-	-	6.4	7.1	6.9	8.7	9.0	8.2	8.2	8.3	8.6
AGTR1	AT₁		Angiotensin	A	-	Lambert	RGB-GDP	0	6		angiotensin II	Phys	-	3	4	1	Gq/11	2	nc	2'	1'	nc	0	58	100	0	Efficacy	0.00	0.03	0.05	0.00	Gq	0	-	-	58	-	-	-	-	-	-	100	-	-	-	0	-	Efficacy	0.00	-	-	0.03	-	-	-	-	-	-	0.05	-	-	-	0.00	-
AGTR1	AT₁		Angiotensin	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	3	4	1	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	-	0.00	-
AGTR1	AT₁		Angiotensin	A	-	Inoue	TGF𝛼	5	1		angiotensin II	Phys	-	3	4	1	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	10.0	-	-	-	-	-
AGTR1	AT₁		Angiotensin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	3	4	1	Gi/o	2	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AGTR1	AT₁		Angiotensin	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	4	1	Gq/11	3	nc	2'	1'	3'	0	46	67	32	-	-	-	-	-	G11	0	-	-	45	76	-	-	71	79	77	66	100	91	92	31	96	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AGTR2	AT₂		Angiotensin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AGTR2	AT₂		Angiotensin	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
APJ	Apelin		Apelin	A	-	Bouvier	GEMTA	3	12		[Pyr¹]apelin-13	Phys	-	3	1	1	Gi/o	3	nc	1'	3'	2'	0	100	63	72	log(Emax/EC50)	0.0	9.3	5.8	6.7	Gi1	0	-	-	100	99	-	-	85	94	96	0	0	0	63	72	64	log(Emax/EC50)	0.0	-	-	9.3	9.2	-	-	7.9	8.7	8.9	0.0	0.0	0.0	5.8	6.7	5.9
APJ	Apelin		Apelin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		apelin-17	Phys	-	3	1	1	Gi/o	1	nc	1'	2'	nc	0	100	0	0	Activation rate (s^-1)	0.0	5.8	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	5.8	-	0.0	-	-	0.0	-	0.0
APJ	Apelin		Apelin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	3	1	1	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
APJ	Apelin		Apelin	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	1	1	Gi/o	3	nc	1'	3'	2'	0	100	32	36	-	-	-	-	-	Gi1	0	-	-	100	99	-	-	85	97	96	0	0	0	32	72	32	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NMBR	BB₁		Bombesin	A	-	Inoue	TGF𝛼	5	1		neuromedin B	Phys	-	-	2	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	10.4	-	-	-	-	-
NMBR	BB₁		Bombesin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	-	2	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NMBR	BB₁		Bombesin	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	2	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GRPR	BB₂		Bombesin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		gastrin-releasing peptide	Phys	-	1	3	1	Gq/11	3	nc	3'	1'	2'	0	2	100	6	Activation rate (s^-1)	0.0	0.1	4.6	0.3	Gq	0	-	-	-	-	-	-	-	2	-	100	-	-	0	-	6	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.1	-	4.6	-	-	0.0	-	0.3
GRPR	BB₂		Bombesin	A	-	Inoue	TGF𝛼	5	1		bombesin	Phys	-	1	3	1	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	9.9	-	-	-	-	-
GRPR	BB₂		Bombesin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	3	1	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GRPR	BB₂		Bombesin	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	3	1	Gq/11	3	nc	3'	1'	2'	0	2	100	6	-	-	-	-	-	Gq	0	-	-	-	-	-	-	-	2	-	100	-	-	0	-	6	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
BRS3	BB₃		Bombesin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		[125I][D-Tyr6,β-Ala11,Phe13,Nle14]bombesin-(6-14)	Phys	-	-	2	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	Activation rate (s^-1)	0.0	0.0	0.1	0.0	Gq	0	-	-	-	-	-	-	-	0	-	100	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.0	-	0.1	-	-	0.0	-	0.0
BRS3	BB₃		Bombesin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	-	2	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
BRS3	BB₃		Bombesin	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	2	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	-	-	-	-	-	Gq	0	-	-	-	-	-	-	-	0	-	100	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
BKRB1	B₁		Bradykinin	A	-	Bouvier	GEMTA	3	12		kallidin	Phys	-	2	3	-	Gq/11	2	nc	2'	1'	nc	0	94	100	0	log(Emax/EC50)	0.0	6.0	6.4	0.0	G15	0	-	-	88	88	-	-	85	88	94	95	95	95	100	0	0	log(Emax/EC50)	0.0	-	-	5.7	5.6	-	-	5.5	5.6	6.0	6.1	6.1	6.1	6.4	0.0	0.0
BKRB1	B₁		Bradykinin	A	-	Inoue	TGF𝛼	5	1		bradykinin	Phys	-	2	3	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.5	-	-	-	-	-
BKRB1	B₁		Bradykinin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	3	-	Gq/11	2	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
BKRB1	B₁		Bradykinin	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	3	-	Gq/11	2	nc	2'	1'	nc	0	94	100	0	-	-	-	-	-	G15	0	-	-	88	88	-	-	85	88	94	95	95	95	100	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
BKRB2	B₂		Bradykinin	A	-	Bouvier	GEMTA	3	12		kallidin	Phys	1	3	4	2	Gq/11	3	nc	3'	1'	2'	0	85	100	98	log(Emax/EC50)	0.0	8.0	9.4	9.2	Gq	0	-	-	83	77	-	-	85	75	82	100	100	100	93	98	95	log(Emax/EC50)	0.0	-	-	7.9	7.3	-	-	8.0	7.0	7.7	9.4	9.4	9.4	8.7	9.2	9.0
BKRB2	B₂		Bradykinin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		bradykinin	Phys	1	3	4	2	Gq/11	3	nc	3'	1'	2'	0	3	100	8	Activation rate (s^-1)	0.0	0.2	4.4	0.4	Gq	0	-	-	-	-	-	-	-	3	-	100	-	-	4	-	8	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.2	-	4.4	-	-	0.2	-	0.4
BKRB2	B₂		Bradykinin	A	-	Inoue	TGF𝛼	5	1		kallidin	Phys	1	3	4	2	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	9.8	-	-	-	-	-
BKRB2	B₂		Bradykinin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	3	4	2	Gq/11	3	1'	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
BKRB2	B₂		Bradykinin	A	-	GproteinDb	merged data	-	-	-	-	-	1	3	4	2	Gq/11	3	nc	3'	1'	2'	0	44	100	53	-	-	-	-	-	Gq	0	-	-	83	77	-	-	85	39	82	100	100	100	48	98	52	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCKAR	CCK₁		Cholecystokinin	A	-	Bouvier	GEMTA	3	12		CCK-8	Phys	3	2	4	2	G12/13	4	4'	3'	2'	1'	83	88	99	100	log(Emax/EC50)	8.1	8.5	9.7	9.7	G12	83	-	-	87	84	-	-	80	88	87	96	98	99	90	100	94	log(Emax/EC50)	8.1	-	-	8.4	8.2	-	-	7.8	8.5	8.5	9.4	9.6	9.7	8.8	9.7	9.2
CCKAR	CCK₁		Cholecystokinin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		CCK-8	Phys	3	2	4	2	Gq/11	4	4'	2'	1'	3'	5	78	100	18	Activation rate (s^-1)	0.2	3.2	4.1	0.7	Gq	5	-	-	-	-	-	-	-	78	-	100	-	-	14	-	18	Activation rate (s^-1)	0.2	-	-	-	-	-	-	-	3.2	-	4.1	-	-	0.6	-	0.7
CCKAR	CCK₁		Cholecystokinin	A	-	Inoue	TGF𝛼	5	1		CCK-8	Phys	3	2	4	2	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	10.5	-	-	-	-	-
CCKAR	CCK₁		Cholecystokinin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	3	2	4	2	Gq/11	2	2'	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCKAR	CCK₁		Cholecystokinin	A	-	GproteinDb	merged data	-	-	-	-	-	3	2	4	2	Gq/11	4	4'	2'	1'	3'	44	83	100	59	-	-	-	-	-	G12	44	-	-	87	84	-	-	80	83	87	98	98	99	52	100	56	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GASR	CCK₂		Cholecystokinin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		CCK-8	Phys	-	1	3	1	Gq/11	3	nc	2'	1'	3'	0	34	100	12	Activation rate (s^-1)	0.0	1.4	4.1	0.5	Gq	0	-	-	-	-	-	-	-	34	-	100	-	-	29	-	12	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	1.4	-	4.1	-	-	1.2	-	0.5
GASR	CCK₂		Cholecystokinin	A	-	Inoue	TGF𝛼	5	1		CCK-8	Phys	-	1	3	1	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	10.0	-	-	-	-	-
GASR	CCK₂		Cholecystokinin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	3	1	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GASR	CCK₂		Cholecystokinin	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	3	1	Gq/11	3	nc	2'	1'	3'	0	34	100	12	-	-	-	-	-	Gq	0	-	-	-	-	-	-	-	34	-	100	-	-	29	-	12	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
C5AR1	C5a₁		Complement peptide	A	-	Bouvier	GEMTA	3	12		C5a	Phys	-	4	2	-	Gq/11	2	nc	2'	1'	nc	0	99	100	0	log(Emax/EC50)	0.0	9.2	9.3	0.0	G15	0	-	-	98	99	-	-	88	92	98	0	0	0	100	0	0	log(Emax/EC50)	0.0	-	-	9.1	9.2	-	-	8.1	8.5	9.1	0.0	0.0	0.0	9.3	0.0	0.0
C5AR1	C5a₁		Complement peptide	A	-	Lambert	RGB-GDP	0	6	-	C5a	Phys	-	4	2	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Efficacy	0.00	0.05	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Efficacy	0.00	-	-	0.05	-	-	-	-	-	-	0.00	-	-	-	0.00	-
C5AR1	C5a₁		Complement peptide	A	-	Lambert	RGB-GDP	0	6	-	None (constitutive activity)	-	-	4	2	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Econstitutive	0.00	0.03	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.03	-	-	-	-	-	-	0.00	-	-	-	0.00	-
C5AR1	C5a₁		Complement peptide	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	4	2	-	Gi/o	2	-	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
C5AR1	C5a₁		Complement peptide	A	-	GproteinDb	merged data	-	-	-	-	-	-	4	2	-	Gi/o	2	nc	1'	2'	nc	0	100	33	0	-	-	-	-	-	G15	0	-	-	99	99	-	-	88	92	98	0	0	0	100	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EDNRA	ET_A		Endothelin	A	-	Bouvier	GEMTA	3	12		endothelin-1	Phys	1	3	5	3	G12/13	4	4'	2'	3'	1'	78	96	93	100	log(Emax/EC50)	8.1	9.9	9.6	10.3	G12	78	-	-	90	90	-	-	96	91	93	92	91	93	79	100	92	log(Emax/EC50)	8.1	-	-	9.3	9.3	-	-	9.9	9.4	9.6	9.5	9.5	9.6	8.2	10.3	9.6
EDNRA	ET_A		Endothelin	A	-	Lambert	RGB-GDP	0	6		endothelin-1	Phys	1	3	5	3	Gi/o	3	nc	1'	2'	3'	0	100	94	36	Efficacy	0.00	0.06	0.06	0.02	Gi1	0	-	-	100	-	-	-	-	-	-	94	-	-	-	36	-	Efficacy	0.00	-	-	0.06	-	-	-	-	-	-	0.06	-	-	-	0.02	-
EDNRA	ET_A		Endothelin	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	1	3	5	3	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	-	0.00	-
EDNRA	ET_A		Endothelin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		endothelin-2	Phys	1	3	5	3	Gi/o	3	nc	1'	2'	3'	0	100	40	18	Activation rate (s^-1)	0.0	0.5	0.2	0.1	GoA	0	-	-	-	-	-	-	-	100	-	40	-	-	0	-	18	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.5	-	0.2	-	-	0.0	-	0.1
EDNRA	ET_A		Endothelin	A	-	Inoue	TGF𝛼	5	1		endothelin-1	Phys	1	3	5	3	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	10.0	-	-	-	-	-
EDNRA	ET_A		Endothelin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	3	5	3	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EDNRA	ET_A		Endothelin	A	-	GproteinDb	merged data	-	-	-	-	-	1	3	5	3	Gi/o	4	4'	1'	2'	3'	20	74	57	38	-	-	-	-	-	Gz	20	-	-	63	90	-	-	96	96	93	56	91	93	40	45	55	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EDNRB	ET_B		Endothelin	A	-	Lambert	RGB-GDP	0	6		endothelin-1	Phys	1	3	4	2	Gi/o	3	nc	1'	2'	3'	0	100	54	12	Efficacy	0.00	0.09	0.05	0.01	Gi1	0	-	-	100	-	-	-	-	-	-	54	-	-	-	12	-	Efficacy	0.00	-	-	0.09	-	-	-	-	-	-	0.05	-	-	-	0.01	-
EDNRB	ET_B		Endothelin	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	1	3	4	2	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	-	0.00	-
EDNRB	ET_B		Endothelin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		endothelin-2	Phys	1	3	4	2	Gi/o	3	nc	1'	2'	3'	0	100	24	20	Activation rate (s^-1)	0.0	10.2	2.4	2.0	GoA	0	-	-	-	-	-	-	-	100	-	24	-	-	0	-	20	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	10.2	-	2.4	-	-	0.0	-	2.0
EDNRB	ET_B		Endothelin	A	-	Inoue	TGF𝛼	5	1		endothelin-1	Phys	1	3	4	2	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	9.4	-	-	-	-	-
EDNRB	ET_B		Endothelin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	3	4	2	Gq/11	3	1'	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EDNRB	ET_B		Endothelin	A	-	GproteinDb	merged data	-	-	-	-	-	1	3	4	2	Gi/o	3	nc	1'	2'	3'	0	67	26	11	-	-	-	-	-	GoA	0	-	-	50	-	-	-	-	100	-	26	-	-	0	6	20	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FPR1	FPR1		Formylpeptide	A	-	Lambert	RGB-GDP	0	6		WKYMVM	Surr	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Efficacy	0.00	0.12	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Efficacy	0.00	-	-	0.12	-	-	-	-	-	-	0.00	-	-	-	0.00	-
FPR1	FPR1		Formylpeptide	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Econstitutive	0.00	0.07	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.07	-	-	-	-	-	-	0.00	-	-	-	0.00	-
FPR1	FPR1		Formylpeptide	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	3	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FPR1	FPR1		Formylpeptide	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FPR2	FPR2/ALX		Formylpeptide	A	-	Lambert	RGB-GDP	0	6		WKYMVM	Surr	-	3	1	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Efficacy	0.00	0.09	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Efficacy	0.00	-	-	0.09	-	-	-	-	-	-	0.00	-	-	-	0.00	-
FPR2	FPR2/ALX		Formylpeptide	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	3	1	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Econstitutive	0.00	0.05	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.05	-	-	-	-	-	-	0.00	-	-	-	0.00	-
FPR2	FPR2/ALX		Formylpeptide	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	3	1	-	Gi/o	2	-	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FPR2	FPR2/ALX		Formylpeptide	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	1	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FPR3	FPR3		Formylpeptide	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FPR3	FPR3		Formylpeptide	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GALR1	GAL₁		Galanin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		galanin	Phys	-	2	-	-	Gi/o	1	nc	1'	2'	nc	0	100	0	0	Activation rate (s^-1)	0.0	6.0	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	6.0	-	0.0	-	-	0.0	-	0.0
GALR1	GAL₁		Galanin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GALR1	GAL₁		Galanin	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GALR2	GAL₂		Galanin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		galanin	Phys	-	2	3	2	Gq/11	3	nc	3'	1'	2'	0	11	100	17	Activation rate (s^-1)	0.0	0.1	1.1	0.2	Gq	0	-	-	-	-	-	-	-	11	-	100	-	-	7	-	17	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.1	-	1.1	-	-	0.1	-	0.2
GALR2	GAL₂		Galanin	A	-	Inoue	TGF𝛼	5	1		galanin	Phys	-	2	3	2	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.1	-	-	-	-	-
GALR2	GAL₂		Galanin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	3	2	Gq/11	3	-	2'	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GALR2	GAL₂		Galanin	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	3	2	Gq/11	3	nc	3'	1'	2'	0	11	100	17	-	-	-	-	-	Gq	0	-	-	-	-	-	-	-	11	-	100	-	-	7	-	17	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GALR3	GAL₃		Galanin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		galanin	Phys	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	0.1	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.1	-	0.0	-	-	0.0	-	0.0
GALR3	GAL₃		Galanin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GALR3	GAL₃		Galanin	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GHSR	Ghrelin		Ghrelin	A	-	Bouvier	GEMTA	3	12		ghrelin	Phys	-	2	3	2	G12/13	3	nc	3'	2'	1'	0	88	90	100	log(Emax/EC50)	0.0	8.2	8.3	9.3	G12	0	-	-	85	82	-	-	88	85	88	90	88	89	89	100	90	log(Emax/EC50)	0.0	-	-	7.9	7.7	-	-	8.2	7.9	8.2	8.3	8.2	8.3	8.3	9.3	8.4
GHSR	Ghrelin		Ghrelin	A	-	Inoue	TGF𝛼	5	1		ibutamoren	Surr	-	2	3	2	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	9.2	-	-	-	-	-
GHSR	Ghrelin		Ghrelin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	3	2	Gq/11	3	-	2'	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GHSR	Ghrelin		Ghrelin	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	3	2	G12/13	3	nc	3'	2'	1'	0	88	90	100	-	-	-	-	-	G12	0	-	-	85	82	-	-	88	85	88	90	88	89	89	100	90	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNRHR	GnRH₁		Gonadotrophin-releasing hormone	A	-	Bouvier	GEMTA	3	12		GnRH I	Phys	-	1	3	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	log(Emax/EC50)	0.0	0.0	8.9	0.0	Gq	0	-	-	0	0	-	-	0	0	0	100	100	92	94	0	0	log(Emax/EC50)	0.0	-	-	0.0	0.0	-	-	0.0	0.0	0.0	8.9	8.9	8.2	8.3	0.0	0.0
GNRHR	GnRH₁		Gonadotrophin-releasing hormone	A	-	Inoue	TGF𝛼	5	1		leuprolide	Surr	-	1	3	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	9.1	-	-	-	-	-
GNRHR	GnRH₁		Gonadotrophin-releasing hormone	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	3	-	Gq/11	2	-	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNRHR	GnRH₁		Gonadotrophin-releasing hormone	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	3	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	-	-	-	-	-	Gq	0	-	-	0	0	-	-	0	0	0	100	100	92	94	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
KISSR	Kisspeptin		Kisspeptin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		kisspeptin-10	Phys	-	-	3	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	Activation rate (s^-1)	0.0	0.0	1.8	0.0	Gq	0	-	-	-	-	-	-	-	0	-	100	-	-	29	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.0	-	1.8	-	-	0.5	-	0.0
KISSR	Kisspeptin		Kisspeptin	A	-	Inoue	TGF𝛼	5	1		kisspeptin-10	Phys	-	-	3	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.9	-	-	-	-	-
KISSR	Kisspeptin		Kisspeptin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	-	3	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
KISSR	Kisspeptin		Kisspeptin	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	3	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	-	-	-	-	-	Gq	0	-	-	-	-	-	-	-	0	-	100	-	-	29	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MCHR1	MCH₁		Melanin-concentrating hormone	A	-	Inoue	TGF𝛼	5	1		melanin-concentrating hormone	Phys	1	1	2	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.2	-	-	-	-	-
MCHR1	MCH₁		Melanin-concentrating hormone	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	1	2	-	Gq/11	3	1'	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MCHR1	MCH₁		Melanin-concentrating hormone	A	-	GproteinDb	merged data	-	-	-	-	-	1	1	2	-	Gq/11	3	1'	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MCHR2	MCH₂		Melanin-concentrating hormone	A	-	Inoue	TGF𝛼	5	1		melanin-concentrating hormone	Phys	-	-	2	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.4	-	-	-	-	-
MCHR2	MCH₂		Melanin-concentrating hormone	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	-	2	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MCHR2	MCH₂		Melanin-concentrating hormone	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	2	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MSHR	MC₁		Melanocortin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		α-MSH	Phys	2	-	-	-	Gs	1	1'	nc	2'	nc	100	0	5	0	Activation rate (s^-1)	0.5	0.0	0.0	0.0	GsL	100	-	-	-	-	-	-	-	0	-	0	-	-	5	-	0	Activation rate (s^-1)	0.5	-	-	-	-	-	-	-	0.0	-	0.0	-	-	0.0	-	0.0
MSHR	MC₁		Melanocortin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	2	-	-	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MSHR	MC₁		Melanocortin	A	-	GproteinDb	merged data	-	-	-	-	-	2	-	-	-	Gs	2	1'	nc	2'	nc	100	0	5	0	-	-	-	-	-	GsL	100	-	-	-	-	-	-	-	0	-	0	-	-	5	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ACTHR	MC₂		Melanocortin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	-	-	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ACTHR	MC₂		Melanocortin	A	-	GproteinDb	merged data	-	-	-	-	-	1	-	-	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MC3R	MC₃		Melanocortin	A	-	Bouvier	GEMTA	3	12		γ-MSH	Phys	3	1	3	1	Gq/11	4	2'	3'	1'	4'	92	75	100	61	log(Emax/EC50)	9.5	7.8	10.3	6.3	G15	92	-	-	0	0	-	-	75	0	67	0	0	0	100	61	60	log(Emax/EC50)	9.5	-	-	0.0	0.0	-	-	7.8	0.0	6.9	0.0	0.0	0.0	10.3	6.3	6.2
MC3R	MC₃		Melanocortin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		α-MSH	Phys	3	1	3	1	Gs	2	1'	nc	2'	nc	100	0	94	0	Activation rate (s^-1)	0.1	0.0	0.1	0.0	GsL	100	-	-	-	-	-	-	-	0	-	0	-	-	94	-	0	Activation rate (s^-1)	0.1	-	-	-	-	-	-	-	0.0	-	0.0	-	-	0.1	-	0.0
MC3R	MC₃		Melanocortin	A	-	Inoue	TGF𝛼	5	1		α-MSH	Phys	3	1	3	1	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.5	-	-	-	-	-
MC3R	MC₃		Melanocortin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	3	1	3	1	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MC3R	MC₃		Melanocortin	A	-	GproteinDb	merged data	-	-	-	-	-	3	1	3	1	Gq/11	4	2'	3'	1'	4'	96	38	97	30	-	-	-	-	-	G15	96	-	-	0	0	-	-	75	0	67	0	0	0	97	61	30	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MC4R	MC₄		Melanocortin	A	-	Bouvier	GEMTA	3	12		α-MSH	Phys	3	2	2	1	Gq/11	4	2'	3'	1'	4'	99	71	100	59	log(Emax/EC50)	7.9	5.7	8.1	4.7	G15	99	-	-	0	0	-	-	71	0	0	0	0	0	100	0	59	log(Emax/EC50)	7.9	-	-	0.0	0.0	-	-	5.7	0.0	0.0	0.0	0.0	0.0	8.1	0.0	4.7
MC4R	MC₄		Melanocortin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		α-MSH	Phys	3	2	2	1	Gs	3	1'	2'	3'	nc	100	43	25	0	Activation rate (s^-1)	0.5	0.2	0.1	0.0	GsL	100	-	-	-	-	-	-	-	43	-	0	-	-	25	-	0	Activation rate (s^-1)	0.5	-	-	-	-	-	-	-	0.2	-	0.0	-	-	0.1	-	0.0
MC4R	MC₄		Melanocortin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	3	2	2	1	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MC4R	MC₄		Melanocortin	A	-	GproteinDb	merged data	-	-	-	-	-	3	2	2	1	Gs	4	1'	3'	2'	4'	100	57	62	30	-	-	-	-	-	GsL	100	-	-	0	0	-	-	71	22	0	0	0	0	62	0	30	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MC5R	MC₅		Melanocortin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		α-MSH	Phys	2	-	1	-	Gq/11	2	2'	nc	1'	nc	97	0	100	0	Activation rate (s^-1)	0.1	0.0	0.2	0.0	G15	97	-	-	-	-	-	-	-	0	-	62	-	-	100	-	0	Activation rate (s^-1)	0.1	-	-	-	-	-	-	-	0.0	-	0.1	-	-	0.2	-	0.0
MC5R	MC₅		Melanocortin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	2	-	1	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MC5R	MC₅		Melanocortin	A	-	GproteinDb	merged data	-	-	-	-	-	2	-	1	-	Gq/11	2	2'	nc	1'	nc	97	0	100	0	-	-	-	-	-	G15	97	-	-	-	-	-	-	-	0	-	62	-	-	100	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MTLR	Motilin		Motilin	A	-	Inoue	TGF𝛼	5	1		motilin	Phys	-	-	2	1	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	9.7	-	-	-	-	-
MTLR	Motilin		Motilin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	-	2	1	G12/13	2	-	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MTLR	Motilin		Motilin	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	2	1	G12/13	2	-	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NMUR1	NMU1		Neuromedin U	A	-	Inoue	TGF𝛼	5	1		neuromedin U-25	Phys	-	-	2	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.6	-	-	-	-	-
NMUR1	NMU1		Neuromedin U	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	-	2	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NMUR1	NMU1		Neuromedin U	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	2	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NMUR2	NMU2		Neuromedin U	A	-	Inoue	TGF𝛼	5	1		neuromedin U-25	Phys	-	-	2	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.9	-	-	-	-	-
NMUR2	NMU2		Neuromedin U	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	-	2	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NMUR2	NMU2		Neuromedin U	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	2	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPFF1	NPFF1		Neuropeptide FF/neuropeptide AF	A	-	Bouvier	GEMTA	3	12		RFRP-3	Phys	-	3	1	1	Gi/o	3	nc	1'	2'	3'	0	100	76	69	log(Emax/EC50)	0.0	9.4	7.1	6.5	Gz	0	-	-	85	83	-	-	100	88	94	0	0	0	76	65	69	log(Emax/EC50)	0.0	-	-	7.9	7.8	-	-	9.4	8.2	8.8	0.0	0.0	0.0	7.1	6.1	6.5
NPFF1	NPFF1		Neuropeptide FF/neuropeptide AF	A	-	Martemyanov	FreeGβγ-Nluc	2	5		neuropeptide FF	Phys	-	3	1	1	Gi/o	1	nc	1'	2'	nc	0	100	2	0	Activation rate (s^-1)	0.0	1.0	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	2	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	1.0	-	0.0	-	-	0.0	-	0.0
NPFF1	NPFF1		Neuropeptide FF/neuropeptide AF	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	3	1	1	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPFF1	NPFF1		Neuropeptide FF/neuropeptide AF	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	1	1	Gi/o	3	nc	1'	2'	3'	0	100	39	34	-	-	-	-	-	Gz	0	-	-	85	83	-	-	100	94	94	0	0	0	39	65	34	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPFF2	NPFF2		Neuropeptide FF/neuropeptide AF	A	-	Bouvier	GEMTA	3	12		neuropeptide FF	Phys	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	log(Emax/EC50)	0.0	7.7	0.0	0.0	Gz	0	-	-	84	82	-	-	100	89	97	0	0	0	0	0	0	log(Emax/EC50)	0.0	-	-	6.5	6.3	-	-	7.7	6.9	7.5	0.0	0.0	0.0	0.0	0.0	0.0
NPFF2	NPFF2		Neuropeptide FF/neuropeptide AF	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPFF2	NPFF2		Neuropeptide FF/neuropeptide AF	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	Gz	0	-	-	84	82	-	-	100	89	97	0	0	0	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPSR1	NPS		Neuropeptide S	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	-	1	-	Gq/11	2	2'	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPSR1	NPS		Neuropeptide S	A	-	GproteinDb	merged data	-	-	-	-	-	1	-	1	-	Gq/11	2	2'	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPBW1	NPBW1		Neuropeptide W/neuropeptide B	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPBW1	NPBW1		Neuropeptide W/neuropeptide B	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPBW2	NPBW2		Neuropeptide W/neuropeptide B	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPBW2	NPBW2		Neuropeptide W/neuropeptide B	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPY1R	Y₁		Neuropeptide Y	A	-	Bouvier	GEMTA	3	12		neuropeptide Y	Phys	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	log(Emax/EC50)	0.0	9.3	0.0	0.0	Gz	0	-	-	97	94	-	-	100	89	96	0	0	0	0	0	0	log(Emax/EC50)	0.0	-	-	9.0	8.7	-	-	9.3	8.2	8.9	0.0	0.0	0.0	0.0	0.0	0.0
NPY1R	Y₁		Neuropeptide Y	A	-	Martemyanov	FreeGβγ-Nluc	2	5		neuropeptide Y	Phys	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	0.2	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.2	-	0.0	-	-	0.0	-	0.0
NPY1R	Y₁		Neuropeptide Y	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	3	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPY1R	Y₁		Neuropeptide Y	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	Gz	0	-	-	97	94	-	-	100	94	96	0	0	0	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPY2R	Y₂		Neuropeptide Y	A	-	Martemyanov	FreeGβγ-Nluc	2	5		neuropeptide Y	Phys	-	2	1	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	2.1	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	2.1	-	0.0	-	-	0.0	-	0.0
NPY2R	Y₂		Neuropeptide Y	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	1	-	Gi/o	2	-	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPY2R	Y₂		Neuropeptide Y	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	1	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPY4R	Y₄		Neuropeptide Y	A	-	Martemyanov	FreeGβγ-Nluc	2	5		neuropeptide Y	Phys	-	2	1	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	0.5	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.5	-	0.0	-	-	0.0	-	0.0
NPY4R	Y₄		Neuropeptide Y	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	1	-	Gi/o	2	-	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPY4R	Y₄		Neuropeptide Y	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	1	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPY5R	Y₅		Neuropeptide Y	A	-	Bouvier	GEMTA	3	12		neuropeptide Y	Phys	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	log(Emax/EC50)	0.0	6.9	0.0	0.0	GoA	0	-	-	0	0	-	-	92	100	99	0	0	0	0	0	0	log(Emax/EC50)	0.0	-	-	0.0	0.0	-	-	6.4	6.9	6.9	0.0	0.0	0.0	0.0	0.0	0.0
NPY5R	Y₅		Neuropeptide Y	A	-	Martemyanov	FreeGβγ-Nluc	2	5		neuropeptide Y	Phys	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	0.1	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.1	-	0.0	-	-	0.0	-	0.0
NPY5R	Y₅		Neuropeptide Y	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	3	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPY5R	Y₅		Neuropeptide Y	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	GoA	0	-	-	0	0	-	-	92	100	99	0	0	0	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NTR1	NTS₁		Neurotensin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		neurotensin	Phys	1	3	4	2	Gq/11	3	nc	2'	1'	3'	0	35	100	29	Activation rate (s^-1)	0.0	1.4	4.2	1.2	Gq	0	-	-	-	-	-	-	-	35	-	100	-	-	22	-	29	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	1.4	-	4.2	-	-	0.9	-	1.2
NTR1	NTS₁		Neurotensin	A	-	Roth	TRUPATH	1	15		JMV431	Surr	1	3	4	2	Gq/11	3	nc	2'	1'	3'	0	97	100	97	log(Emax/EC50)	0.0	9.0	9.3	9.0	G11	0	0	0	95	96	92	97	97	97	95	95	100	-	98	94	97	log(Emax/EC50)	0.0	0.0	0.0	8.8	8.9	8.5	8.9	8.9	9.0	8.8	8.8	9.3	-	9.1	8.7	9.0
NTR1	NTS₁		Neurotensin	A	-	Inoue	TGF𝛼	5	1		neurotensin	Phys	1	3	4	2	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	9.3	-	-	-	-	-
NTR1	NTS₁		Neurotensin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	3	4	2	Gq/11	3	2'	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NTR1	NTS₁		Neurotensin	A	-	GproteinDb	merged data	-	-	-	-	-	1	3	4	2	Gq/11	3	nc	2'	1'	3'	0	66	100	63	-	-	-	-	-	G11	0	0	0	95	96	92	97	97	66	95	98	100	-	60	94	63	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NTR2	NTS₂		Neurotensin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	-	1	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NTR2	NTS₂		Neurotensin	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	1	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OPRD	δ		Opioid	A	-	Bouvier	GEMTA	3	12		SNC80	Surr	-	3	1	1	Gi/o	3	nc	1'	2'	3'	0	100	72	50	log(Emax/EC50)	0.0	9.3	6.7	4.7	Gz	0	-	-	96	92	-	-	100	95	99	0	0	57	72	0	50	log(Emax/EC50)	0.0	-	-	9.0	8.6	-	-	9.3	8.8	9.3	0.0	0.0	5.3	6.7	0.0	4.7
OPRD	δ		Opioid	A	-	Martemyanov	FreeGβγ-Nluc	2	5		[Leu]enkephalin	Phys	-	3	1	1	Gi/o	1	nc	1'	2'	nc	0	100	1	0	Activation rate (s^-1)	0.0	3.8	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	1	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	3.8	-	0.0	-	-	0.0	-	0.0
OPRD	δ		Opioid	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	3	1	1	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OPRD	δ		Opioid	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	1	1	Gi/o	3	nc	1'	2'	3'	0	100	36	25	-	-	-	-	-	Gz	0	-	-	96	92	-	-	100	98	99	0	0	57	36	0	25	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OPRK	κ		Opioid	A	-	Bouvier	GEMTA	3	12		dynorphin A	Phys	-	3	1	2	Gi/o	3	nc	1'	3'	2'	0	100	74	78	log(Emax/EC50)	0.0	10.2	7.5	7.9	GoB	0	-	-	99	96	-	-	96	96	100	0	0	0	74	78	0	log(Emax/EC50)	0.0	-	-	10.0	9.7	-	-	9.8	9.7	10.2	0.0	0.0	0.0	7.5	7.9	0.0
OPRK	κ		Opioid	A	-	Martemyanov	FreeGβγ-Nluc	2	5		dynorphin A	Phys	-	3	1	2	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	4.6	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	4.6	-	0.0	-	-	0.0	-	0.0
OPRK	κ		Opioid	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	3	1	2	Gi/o	2	-	1'	-	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OPRK	κ		Opioid	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	1	2	Gi/o	3	nc	1'	3'	2'	0	100	37	39	-	-	-	-	-	GoB	0	-	-	99	96	-	-	96	98	100	0	0	0	37	78	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OPRM	μ		Opioid	A	-	Bouvier	GEMTA	3	12		DAMGO	Surr	-	5	2	-	Gi/o	2	nc	1'	2'	nc	0	100	64	0	log(Emax/EC50)	0.0	8.9	5.7	0.0	Gz	0	-	-	92	90	-	-	100	91	96	0	0	0	64	0	0	log(Emax/EC50)	0.0	-	-	8.2	8.1	-	-	8.9	8.1	8.6	0.0	0.0	0.0	5.7	0.0	0.0
OPRM	μ		Opioid	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	5	2	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Econstitutive	0.00	0.03	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.03	-	-	-	-	-	-	0.00	-	-	-	0.00	-
OPRM	μ		Opioid	A	-	Lambert	RGB-GDP	0	6		DAMGO	Surr	-	5	2	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Efficacy	0.00	0.05	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Efficacy	0.00	-	-	0.05	-	-	-	-	-	-	0.00	-	-	-	0.00	-
OPRM	μ		Opioid	A	-	Martemyanov	FreeGβγ-Nluc	2	5		endomorphin-1	Phys	-	5	2	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	1.3	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	1.3	-	0.0	-	-	0.0	-	0.0
OPRM	μ		Opioid	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	5	2	-	Gi/o	2	-	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OPRM	μ		Opioid	A	-	GproteinDb	merged data	-	-	-	-	-	-	5	2	-	Gi/o	2	nc	1'	2'	nc	0	100	16	0	-	-	-	-	-	Gz	0	-	-	97	90	-	-	100	96	96	0	0	0	32	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OPRX	NOP		Opioid	A	-	Bouvier	GEMTA	3	12		nociceptin/orphanin FQ	Phys	-	3	2	-	Gi/o	2	nc	1'	2'	nc	0	100	84	0	log(Emax/EC50)	0.0	10.8	9.1	0.0	Gz	0	-	-	93	89	-	-	100	91	96	0	0	69	84	0	0	log(Emax/EC50)	0.0	-	-	10.1	9.6	-	-	10.8	9.8	10.3	0.0	0.0	7.4	9.1	0.0	0.0
OPRX	NOP		Opioid	A	-	Martemyanov	FreeGβγ-Nluc	2	5		nociceptin/orphanin FQ	Phys	-	3	2	-	Gi/o	2	nc	1'	2'	nc	0	100	1	0	Activation rate (s^-1)	0.0	4.8	0.1	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	1	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	4.8	-	0.0	-	-	0.1	-	0.0
OPRX	NOP		Opioid	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	3	2	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OPRX	NOP		Opioid	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	2	-	Gi/o	2	nc	1'	2'	nc	0	100	42	0	-	-	-	-	-	Gz	0	-	-	93	89	-	-	100	96	96	0	0	69	42	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OX1R	OX₁		Orexin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		orexin-A	Phys	1	2	3	1	Gq/11	3	nc	2'	1'	3'	0	30	100	23	Activation rate (s^-1)	0.0	0.2	0.7	0.2	Gq	0	-	-	-	-	-	-	-	30	-	100	-	-	3	-	23	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.2	-	0.7	-	-	0.0	-	0.2
OX1R	OX₁		Orexin	A	-	Inoue	TGF𝛼	5	1		orexin-A	Phys	1	2	3	1	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.9	-	-	-	-	-
OX1R	OX₁		Orexin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	2	3	1	Gi/o	3	1'	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OX1R	OX₁		Orexin	A	-	GproteinDb	merged data	-	-	-	-	-	1	2	3	1	Gq/11	3	nc	2'	1'	3'	0	30	100	23	-	-	-	-	-	Gq	0	-	-	-	-	-	-	-	30	-	100	-	-	3	-	23	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OX2R	OX₂		Orexin	A	-	Bouvier	GEMTA	3	12		orexin-A	Phys	1	3	4	2	Gq/11	3	nc	2'	1'	3'	0	92	100	73	log(Emax/EC50)	0.0	8.4	9.1	6.7	Gq	0	-	-	74	69	-	-	92	78	83	100	100	94	79	73	66	log(Emax/EC50)	0.0	-	-	6.7	6.3	-	-	8.4	7.1	7.6	9.1	9.1	8.6	7.2	6.7	6.0
OX2R	OX₂		Orexin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		orexin-B	Phys	1	3	4	2	Gq/11	3	nc	2'	1'	3'	0	11	100	7	Activation rate (s^-1)	0.0	0.1	0.8	0.1	Gq	0	-	-	-	-	-	-	-	11	-	100	-	-	0	-	7	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.1	-	0.8	-	-	0.0	-	0.1
OX2R	OX₂		Orexin	A	-	Inoue	TGF𝛼	5	1		orexin-A	Phys	1	3	4	2	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.8	-	-	-	-	-
OX2R	OX₂		Orexin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	3	4	2	Gq/11	3	1'	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OX2R	OX₂		Orexin	A	-	GproteinDb	merged data	-	-	-	-	-	1	3	4	2	Gq/11	3	nc	2'	1'	3'	0	52	100	40	-	-	-	-	-	Gq	0	-	-	74	69	-	-	92	44	83	100	100	94	40	73	36	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
QRFPR	QRFP		Peptide P518	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	1	-	Gq/11	2	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
QRFPR	QRFP		Peptide P518	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	1	-	Gq/11	2	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PRLHR	PrRP		Prolactin-releasing peptide	A	-	Inoue	TGF𝛼	5	1		PrRP-20	Phys	-	-	1	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.8	-	-	-	-	-
PAR1	PAR1		Proteinase-activated	A	-	Bouvier	GEMTA	3	12		TFLLR-NH₂	Phys	-	1	2	1	G12/13	3	nc	3'	2'	1'	0	86	93	100	log(Emax/EC50)	0.0	5.6	6.1	6.5	G13	0	-	-	58	66	-	-	86	73	82	93	93	81	87	0	100	log(Emax/EC50)	0.0	-	-	3.8	4.3	-	-	5.6	4.8	5.4	6.1	6.1	5.3	5.7	0.0	6.5
PAR1	PAR1		Proteinase-activated	A	-	Inoue	TGF𝛼	5	1		TFLLR-NH₂	Phys	-	1	2	1	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.1	-	-	-	-	-
PAR1	PAR1		Proteinase-activated	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	2	1	G12/13	3	nc	3'	2'	1'	0	86	93	100	-	-	-	-	-	G13	0	-	-	58	66	-	-	86	73	82	93	93	81	87	0	100	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PAR2	PAR2		Proteinase-activated	A	-	Bouvier	GEMTA	3	12		PAR2 peptide	Phys	-	1	1	1	G12/13	3	nc	2'	3'	1'	0	89	86	100	log(Emax/EC50)	0.0	5.9	5.6	6.6	G12	0	-	-	78	79	-	-	84	80	89	71	86	77	84	100	97	log(Emax/EC50)	0.0	-	-	5.1	5.2	-	-	5.5	5.2	5.9	4.6	5.6	5.1	5.5	6.6	6.4
PAR2	PAR2		Proteinase-activated	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	1	1	G12/13	3	nc	2'	3'	1'	0	89	86	100	-	-	-	-	-	G12	0	-	-	78	79	-	-	84	80	89	71	86	77	84	100	97	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PAR3	PAR3		Proteinase-activated	A	-	Inoue	TGF𝛼	5	1		thrombin	Phys	-	-	1	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.2	-	-	-	-	-
PAR4	PAR4		Proteinase-activated	A	-	Inoue	TGF𝛼	5	1		thrombin	Phys	-	-	1	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.4	-	-	-	-	-
RXFP1	RXFP1		Relaxin family peptide	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	1	-	-	Gs	2	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
RXFP1	RXFP1		Relaxin family peptide	A	-	GproteinDb	merged data	-	-	-	-	-	1	1	-	-	Gs	2	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
RXFP2	RXFP2		Relaxin family peptide	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	1	-	-	Gi/o	2	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
RXFP2	RXFP2		Relaxin family peptide	A	-	GproteinDb	merged data	-	-	-	-	-	1	1	-	-	Gi/o	2	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
RL3R1	RXFP3		Relaxin family peptide	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
RL3R1	RXFP3		Relaxin family peptide	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
RL3R2	RXFP4		Relaxin family peptide	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
RL3R2	RXFP4		Relaxin family peptide	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SSR1	SST1		Somatostatin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		SRIF-14	Phys	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	0.2	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.2	-	0.0	-	-	0.0	-	0.0
SSR1	SST1		Somatostatin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SSR1	SST1		Somatostatin	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SSR2	SST2		Somatostatin	A	-	Bouvier	GEMTA	3	12		SRIF-14	Phys	-	3	1	1	Gi/o	3	nc	1'	2'	3'	0	100	75	67	log(Emax/EC50)	0.0	10.7	8.0	7.1	Gz	0	-	-	96	93	-	-	100	90	96	62	0	70	75	67	0	log(Emax/EC50)	0.0	-	-	10.2	10.0	-	-	10.7	9.6	10.2	6.6	0.0	7.5	8.0	7.1	0.0
SSR2	SST2		Somatostatin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		SRIF-14	Phys	-	3	1	1	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	1.8	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	1.8	-	0.0	-	-	0.0	-	0.0
SSR2	SST2		Somatostatin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	3	1	1	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SSR2	SST2		Somatostatin	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	1	1	Gi/o	3	nc	1'	2'	3'	0	100	38	34	-	-	-	-	-	Gz	0	-	-	96	93	-	-	100	95	96	31	0	70	38	67	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SSR3	SST3		Somatostatin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		SRIF-14	Phys	-	2	-	-	Gi/o	1	nc	1'	2'	nc	0	100	2	0	Activation rate (s^-1)	0.0	2.3	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	2	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	2.3	-	0.0	-	-	0.0	-	0.0
SSR3	SST3		Somatostatin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SSR3	SST3		Somatostatin	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	-	Gi/o	2	nc	1'	2'	nc	0	100	2	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	2	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SSR4	SST4		Somatostatin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		SRIF-14	Phys	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	0.2	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.2	-	0.0	-	-	0.0	-	0.0
SSR4	SST4		Somatostatin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SSR4	SST4		Somatostatin	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SSR5	SST5		Somatostatin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		SRIF-14	Phys	-	2	1	-	Gi/o	1	nc	1'	2'	nc	0	100	1	0	Activation rate (s^-1)	0.0	4.4	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	1	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	4.4	-	0.0	-	-	0.0	-	0.0
SSR5	SST5		Somatostatin	A	-	Inoue	TGF𝛼	5	1		SRIF-14	Phys	-	2	1	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.3	-	-	-	-	-
SSR5	SST5		Somatostatin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	1	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SSR5	SST5		Somatostatin	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	1	-	Gi/o	2	nc	1'	2'	nc	0	100	1	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	1	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NK1R	NK₁		Tachykinin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		substance P	Phys	1	1	3	1	Gq/11	3	nc	3'	1'	2'	0	6	100	48	Activation rate (s^-1)	0.0	0.3	4.2	2.0	Gq	0	-	-	-	-	-	-	-	6	-	100	-	-	4	-	48	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.3	-	4.2	-	-	0.2	-	2.0
NK1R	NK₁		Tachykinin	A	-	Inoue	TGF𝛼	5	1		substance P	Phys	1	1	3	1	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	9.5	-	-	-	-	-
NK1R	NK₁		Tachykinin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	1	3	1	Gq/11	2	1'	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NK1R	NK₁		Tachykinin	A	-	GproteinDb	merged data	-	-	-	-	-	1	1	3	1	Gq/11	3	nc	3'	1'	2'	0	6	100	48	-	-	-	-	-	Gq	0	-	-	-	-	-	-	-	6	-	100	-	-	4	-	48	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NK2R	NK₂		Tachykinin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		neurokinin A	Phys	1	1	3	1	Gq/11	3	nc	2'	1'	3'	0	29	100	7	Activation rate (s^-1)	0.0	1.4	4.6	0.3	Gq	0	-	-	-	-	-	-	-	29	-	100	-	-	10	-	7	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	1.4	-	4.6	-	-	0.5	-	0.3
NK2R	NK₂		Tachykinin	A	-	Inoue	TGF𝛼	5	1		neurokinin B	Phys	1	1	3	1	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	9.5	-	-	-	-	-
NK2R	NK₂		Tachykinin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	1	3	1	Gq/11	2	1'	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NK2R	NK₂		Tachykinin	A	-	GproteinDb	merged data	-	-	-	-	-	1	1	3	1	Gq/11	3	nc	2'	1'	3'	0	29	100	7	-	-	-	-	-	Gq	0	-	-	-	-	-	-	-	29	-	100	-	-	10	-	7	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NK3R	NK₃		Tachykinin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		neurokinin B	Phys	-	1	3	1	Gq/11	3	nc	3'	1'	2'	0	7	100	67	Activation rate (s^-1)	0.0	0.2	2.9	1.9	Gq	0	-	-	-	-	-	-	-	7	-	100	-	-	15	-	67	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.2	-	2.9	-	-	0.4	-	1.9
NK3R	NK₃		Tachykinin	A	-	Inoue	TGF𝛼	5	1		neurokinin A	Phys	-	1	3	1	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.2	-	-	-	-	-
NK3R	NK₃		Tachykinin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	3	1	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NK3R	NK₃		Tachykinin	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	3	1	Gq/11	3	nc	3'	1'	2'	0	7	100	67	-	-	-	-	-	Gq	0	-	-	-	-	-	-	-	7	-	100	-	-	15	-	67	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR3	GPR3		A orphans	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	-	-	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR3	GPR3		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	1	-	-	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TRFR	TRH₁		Thyrotropin-releasing hormone	A	-	Inoue	TGF𝛼	5	1		TRH	Phys	-	-	2	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	9.6	-	-	-	-	-
TRFR	TRH₁		Thyrotropin-releasing hormone	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	-	2	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TRFR	TRH₁		Thyrotropin-releasing hormone	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	2	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
UR2R	UT		Urotensin	A	-	Inoue	TGF𝛼	5	1		urotensin-II	Phys	-	-	2	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	9.2	-	-	-	-	-
UR2R	UT		Urotensin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	-	2	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
UR2R	UT		Urotensin	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	2	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
V1AR	V_1A		Vasopressin and oxytocin	A	-	Bouvier	GEMTA	3	12		vasopressin	Phys	-	2	4	-	Gq/11	2	nc	2'	1'	nc	0	80	100	0	log(Emax/EC50)	0.0	7.0	8.7	0.0	G11	0	-	-	78	77	-	-	80	79	78	98	100	93	91	0	0	log(Emax/EC50)	0.0	-	-	6.8	6.7	-	-	7.0	6.9	6.8	8.5	8.7	8.1	7.9	0.0	0.0
V1AR	V_1A		Vasopressin and oxytocin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		vasopressin	Phys	-	2	4	-	Gq/11	2	nc	2'	1'	nc	0	17	100	0	Activation rate (s^-1)	0.0	0.1	0.7	0.0	Gq	0	-	-	-	-	-	-	-	17	-	100	-	-	8	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.1	-	0.7	-	-	0.1	-	0.0
V1AR	V_1A		Vasopressin and oxytocin	A	-	Inoue	TGF𝛼	5	1		vasopressin	Phys	-	2	4	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	10.1	-	-	-	-	-
V1AR	V_1A		Vasopressin and oxytocin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	4	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
V1AR	V_1A		Vasopressin and oxytocin	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	4	-	Gq/11	2	nc	2'	1'	nc	0	48	100	0	-	-	-	-	-	G11	0	-	-	78	77	-	-	80	48	78	99	100	93	50	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
V1BR	V_1B		Vasopressin and oxytocin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		vasopressin	Phys	-	1	3	-	Gq/11	2	nc	2'	1'	nc	0	21	100	0	Activation rate (s^-1)	0.0	0.1	0.6	0.0	Gq	0	-	-	-	-	-	-	-	21	-	100	-	-	9	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.1	-	0.6	-	-	0.1	-	0.0
V1BR	V_1B		Vasopressin and oxytocin	A	-	Inoue	TGF𝛼	5	1		vasopressin	Phys	-	1	3	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	9.5	-	-	-	-	-
V1BR	V_1B		Vasopressin and oxytocin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	3	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
V1BR	V_1B		Vasopressin and oxytocin	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	3	-	Gq/11	2	nc	2'	1'	nc	0	21	100	0	-	-	-	-	-	Gq	0	-	-	-	-	-	-	-	21	-	100	-	-	9	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
V2R	V₂		Vasopressin and oxytocin	A	-	Bouvier	GEMTA	3	12		vasopressin	Phys	4	3	4	2	Gs	4	1'	4'	2'	3'	100	60	88	77	log(Emax/EC50)	10.1	6.1	8.9	7.8	GsL	100	-	-	60	51	-	-	0	55	0	69	70	65	88	0	77	log(Emax/EC50)	10.1	-	-	6.1	5.1	-	-	0.0	5.5	0.0	6.9	7.1	6.5	8.9	0.0	7.8
V2R	V₂		Vasopressin and oxytocin	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	4	3	4	2	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	-	0.00	-
V2R	V₂		Vasopressin and oxytocin	A	-	Lambert	RGB-GDP	0	6		vasopressin	Phys	4	3	4	2	Gs	3	1'	2'	3'	nc	100	42	33	0	Efficacy	0.06	0.03	0.02	0.00	GsL	100	-	-	42	-	-	-	-	-	-	33	-	-	-	0	-	Efficacy	0.06	-	-	0.03	-	-	-	-	-	-	0.02	-	-	-	0.00	-
V2R	V₂		Vasopressin and oxytocin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		vasopressin	Phys	4	3	4	2	Gs	4	1'	3'	2'	4'	100	6	41	5	Activation rate (s^-1)	1.4	0.1	0.6	0.1	GsL	100	-	-	-	-	-	-	-	6	-	11	-	-	41	-	5	Activation rate (s^-1)	1.4	-	-	-	-	-	-	-	0.1	-	0.2	-	-	0.6	-	0.1
V2R	V₂		Vasopressin and oxytocin	A	-	Inoue	TGF𝛼	5	1		vasopressin	Phys	4	3	4	2	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.5	-	-	-	-	-
V2R	V₂		Vasopressin and oxytocin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	4	3	4	2	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
V2R	V₂		Vasopressin and oxytocin	A	-	GproteinDb	merged data	-	-	-	-	-	4	3	4	2	Gs	4	1'	3'	2'	4'	75	27	40	20	-	-	-	-	-	GsL	75	-	-	34	51	-	-	0	30	0	28	70	65	64	0	41	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OXYR	OT		Vasopressin and oxytocin	A	-	Bouvier	GEMTA	3	12		oxytocin	Phys	-	3	5	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	log(Emax/EC50)	0.0	0.0	7.6	0.0	Gq	0	-	-	0	0	-	-	0	0	0	100	100	90	96	0	0	log(Emax/EC50)	0.0	-	-	0.0	0.0	-	-	0.0	0.0	0.0	7.6	7.6	6.8	7.3	0.0	0.0
OXYR	OT		Vasopressin and oxytocin	A	-	Lambert	RGB-GDP	0	6	-	None (constitutive activity)	-	-	3	5	-	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	-	0.00	-
OXYR	OT		Vasopressin and oxytocin	A	-	Lambert	RGB-GDP	0	6	-	oxytocin	Phys	-	3	5	-	Gq/11	2	nc	2'	1'	nc	0	69	100	0	Efficacy	0.00	0.03	0.04	0.00	Gq	0	-	-	69	-	-	-	-	-	-	100	-	-	-	0	-	Efficacy	0.00	-	-	0.03	-	-	-	-	-	-	0.04	-	-	-	0.00	-
OXYR	OT		Vasopressin and oxytocin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		oxytocin	Phys	-	3	5	-	Gq/11	2	nc	2'	1'	nc	0	13	100	0	Activation rate (s^-1)	0.0	0.1	0.6	0.0	Gq	0	-	-	-	-	-	-	-	13	-	100	-	-	17	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.1	-	0.6	-	-	0.1	-	0.0
OXYR	OT		Vasopressin and oxytocin	A	-	Inoue	TGF𝛼	5	1		oxytocin	Phys	-	3	5	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.0	-	-	-	-	-
OXYR	OT		Vasopressin and oxytocin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	3	5	-	Gq/11	2	-	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OXYR	OT		Vasopressin and oxytocin	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	5	-	Gq/11	2	nc	2'	1'	nc	0	20	75	0	-	-	-	-	-	G11	0	-	-	23	0	-	-	0	6	0	75	100	90	56	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CML1	Chemerin		Chemerin receptor	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CML1	Chemerin		Chemerin receptor	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR1	CCR1		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR1	CCR1		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR2	CCR2		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR2	CCR2		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR3	CCR3		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR3	CCR3		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR4	CCR4		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR4	CCR4		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR5	CCR5		Chemokine	A	-	Bouvier	GEMTA	3	12		CCL3	Phys	-	2	1	-	Gi/o	2	nc	1'	2'	nc	0	100	70	0	log(Emax/EC50)	0.0	9.1	6.4	0.0	Gz	0	-	-	98	96	-	-	100	94	97	0	0	0	70	0	0	log(Emax/EC50)	0.0	-	-	8.9	8.7	-	-	9.1	8.5	8.8	0.0	0.0	0.0	6.4	0.0	0.0
CCR5	CCR5		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	1	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR5	CCR5		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	1	-	Gi/o	2	nc	1'	2'	nc	0	100	70	0	-	-	-	-	-	Gz	0	-	-	98	96	-	-	100	94	97	0	0	0	70	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR6	CCR6		Chemokine	A	-	Bouvier	GEMTA	3	12		CCL2	Phys	-	2	1	1	G12/13	3	nc	2'	3'	1'	0	95	95	100	log(Emax/EC50)	0.0	8.2	8.2	8.6	G12	0	-	-	86	94	-	-	95	83	91	0	0	0	95	100	0	log(Emax/EC50)	0.0	-	-	7.3	8.1	-	-	8.2	7.1	7.8	0.0	0.0	0.0	8.2	8.6	0.0
CCR6	CCR6		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	1	1	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR6	CCR6		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	1	1	G12/13	3	nc	2'	3'	1'	0	95	95	100	-	-	-	-	-	G12	0	-	-	86	94	-	-	95	83	91	0	0	0	95	100	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR7	CCR7		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR7	CCR7		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR8	CCR8		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR8	CCR8		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR9	CCR9		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR9	CCR9		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR10	CCR10		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR10	CCR10		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CXCR1	CXCR1		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	1	-	Gi/o	2	-	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CXCR1	CXCR1		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	1	-	Gi/o	2	-	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CXCR2	CXCR2		Chemokine	A	-	Bouvier	GEMTA	3	12		CXCL8	Phys	-	2	1	-	Gi/o	2	nc	1'	2'	nc	0	100	87	0	log(Emax/EC50)	0.0	9.4	8.2	0.0	GoB	0	-	-	99	99	-	-	91	97	100	0	0	0	87	0	0	log(Emax/EC50)	0.0	-	-	9.4	9.3	-	-	8.6	9.1	9.4	0.0	0.0	0.0	8.2	0.0	0.0
CXCR2	CXCR2		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	1	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CXCR2	CXCR2		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	1	-	Gi/o	2	nc	1'	2'	nc	0	100	87	0	-	-	-	-	-	GoB	0	-	-	99	99	-	-	91	97	100	0	0	0	87	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CXCR3	CXCR3		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CXCR3	CXCR3		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CXCR4	CXCR4		Chemokine	A	-	Bouvier	GEMTA	3	12		CXCL12α	Phys	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	log(Emax/EC50)	0.0	8.5	0.0	0.0	Gi2	0	-	-	97	100	-	-	88	92	95	0	0	0	0	0	0	log(Emax/EC50)	0.0	-	-	8.3	8.5	-	-	7.5	7.8	8.1	0.0	0.0	0.0	0.0	0.0	0.0
CXCR4	CXCR4		Chemokine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		CXCL12α	Phys	-	3	-	-	Gi/o	1	nc	1'	2'	nc	0	100	7	0	Activation rate (s^-1)	0.0	0.3	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	7	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.3	-	0.0	-	-	0.0	-	0.0
CXCR4	CXCR4		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	3	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CXCR4	CXCR4		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	-	-	Gi/o	2	nc	1'	2'	nc	0	100	4	0	-	-	-	-	-	Gi2	0	-	-	97	100	-	-	88	96	95	0	0	0	4	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CXCR5	CXCR5		Chemokine	A	-	Bouvier	GEMTA	3	12		CXCL13	Phys	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	log(Emax/EC50)	0.0	8.2	0.0	0.0	GoB	0	-	-	95	94	-	-	99	96	100	0	0	0	0	0	0	log(Emax/EC50)	0.0	-	-	7.7	7.6	-	-	8.1	7.8	8.2	0.0	0.0	0.0	0.0	0.0	0.0
CXCR5	CXCR5		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CXCR5	CXCR5		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	GoB	0	-	-	95	94	-	-	99	96	100	0	0	0	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CXCR6	CXCR6		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CXCR6	CXCR6		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CX3C1	CX₃CR1		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CX3C1	CX₃CR1		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XCR1	XCR1		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XCR1	XCR1		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FSHR	FSH		Glycoprotein hormone	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	1	1	-	Gs	3	1'	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FSHR	FSH		Glycoprotein hormone	A	-	GproteinDb	merged data	-	-	-	-	-	1	1	1	-	Gs	3	1'	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LSHR	LH		Glycoprotein hormone	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	-	1	-	Gs	2	1'	-	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LSHR	LH		Glycoprotein hormone	A	-	GproteinDb	merged data	-	-	-	-	-	1	-	1	-	Gs	2	1'	-	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TSHR	TSH		Glycoprotein hormone	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	-	1	-	Gs	2	1'	-	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TSHR	TSH		Glycoprotein hormone	A	-	GproteinDb	merged data	-	-	-	-	-	1	-	1	-	Gs	2	1'	-	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKR1	PKR₁		Prokineticin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	-	1	-	Gq/11	2	2'	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKR1	PKR₁		Prokineticin	A	-	GproteinDb	merged data	-	-	-	-	-	1	-	1	-	Gq/11	2	2'	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKR2	PKR₂		Prokineticin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	1	1	-	Gq/11	3	2'	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKR2	PKR₂		Prokineticin	A	-	GproteinDb	merged data	-	-	-	-	-	1	1	1	-	Gq/11	3	2'	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FFAR1	FFA1		Free fatty acid	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	1	1	-	Gq/11	3	2'	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FFAR1	FFA1		Free fatty acid	A	-	GproteinDb	merged data	-	-	-	-	-	1	1	1	-	Gq/11	3	2'	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FFAR2	FFA2		Free fatty acid	A	-	Bouvier	GEMTA	3	12		propanoic acid	Phys	-	2	2	-	Gi/o	2	nc	1'	2'	nc	0	100	95	0	log(Emax/EC50)	0.0	4.3	4.1	0.0	Gi1	0	-	-	100	95	-	-	0	0	0	87	90	95	0	0	0	log(Emax/EC50)	0.0	-	-	4.3	4.1	-	-	0.0	0.0	0.0	3.7	3.9	4.1	0.0	0.0	0.0
FFAR2	FFA2		Free fatty acid	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	2	-	Gq/11	2	-	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FFAR2	FFA2		Free fatty acid	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	2	-	Gi/o	2	nc	1'	2'	nc	0	100	95	0	-	-	-	-	-	Gi1	0	-	-	100	95	-	-	0	0	0	87	90	95	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FFAR3	FFA3		Free fatty acid	A	-	Bouvier	GEMTA	3	12		propanoic acid	Phys	-	2	-	1	Gi/o	2	nc	1'	nc	2'	0	100	0	86	log(Emax/EC50)	0.0	5.0	0.0	4.3	GoB	0	-	-	98	99	-	-	89	97	100	0	0	0	0	86	78	log(Emax/EC50)	0.0	-	-	4.8	4.9	-	-	4.4	4.8	5.0	0.0	0.0	0.0	0.0	4.3	3.9
FFAR3	FFA3		Free fatty acid	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	-	1	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FFAR3	FFA3		Free fatty acid	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	1	Gi/o	2	nc	1'	nc	2'	0	100	0	86	-	-	-	-	-	GoB	0	-	-	98	99	-	-	89	97	100	0	0	0	0	86	78	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FFAR4	FFA4		Free fatty acid	A	-	Bouvier	GEMTA	3	12		α-linolenic acid	Phys	-	1	2	1	Gq/11	3	nc	2'	1'	3'	0	92	100	78	log(Emax/EC50)	0.0	4.8	5.2	4.0	G15	0	-	-	91	91	-	-	0	86	92	84	87	96	100	0	78	log(Emax/EC50)	0.0	-	-	4.7	4.7	-	-	0.0	4.4	4.8	4.4	4.5	4.9	5.2	0.0	4.0
FFAR4	FFA4		Free fatty acid	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	2	1	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FFAR4	FFA4		Free fatty acid	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	2	1	Gq/11	3	nc	2'	1'	3'	0	92	100	78	-	-	-	-	-	G15	0	-	-	91	91	-	-	0	86	92	84	87	96	100	0	78	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LT4R1	BLT₁		Leukotriene	A	-	Bouvier	GEMTA	3	12		LTB₄	Phys	-	2	3	1	Gi/o	3	nc	1'	2'	3'	0	100	97	85	log(Emax/EC50)	0.0	10.1	9.7	8.6	GoB	0	-	-	99	99	-	-	91	95	100	59	53	65	97	85	85	log(Emax/EC50)	0.0	-	-	10.0	10.0	-	-	9.2	9.5	10.1	5.9	5.4	6.5	9.7	8.6	8.6
LT4R1	BLT₁		Leukotriene	A	-	Inoue	TGF𝛼	5	1		LTB₄	Phys	-	2	3	1	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.3	-	-	-	-	-
LT4R1	BLT₁		Leukotriene	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	3	1	Gi/o	2	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LT4R1	BLT₁		Leukotriene	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	3	1	Gi/o	3	nc	1'	2'	3'	0	100	97	85	-	-	-	-	-	GoB	0	-	-	99	99	-	-	91	95	100	59	53	65	97	85	85	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LT4R2	BLT₂		Leukotriene	A	-	Bouvier	GEMTA	3	12		LTB₄	Phys	-	2	1	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	log(Emax/EC50)	0.0	8.4	0.0	0.0	Gi1	0	-	-	100	98	-	-	76	92	97	0	0	0	0	0	0	log(Emax/EC50)	0.0	-	-	8.4	8.2	-	-	6.4	7.8	8.2	0.0	0.0	0.0	0.0	0.0	0.0
LT4R2	BLT₂		Leukotriene	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	1	-	Gi/o	2	-	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LT4R2	BLT₂		Leukotriene	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	1	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	Gi1	0	-	-	100	98	-	-	76	92	97	0	0	0	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CLTR1	CysLT₁		Leukotriene	A	-	Bouvier	GEMTA	3	12		LTB₄	Phys	-	2	3	-	Gi/o	2	nc	1'	2'	nc	0	100	89	0	log(Emax/EC50)	0.0	8.3	7.3	0.0	Gz	0	-	-	98	98	-	-	100	92	98	85	84	80	89	0	0	log(Emax/EC50)	0.0	-	-	8.2	8.1	-	-	8.3	7.6	8.1	7.0	6.9	6.6	7.3	0.0	0.0
CLTR1	CysLT₁		Leukotriene	A	-	Inoue	TGF𝛼	5	1		LTD₄	Phys	-	2	3	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	9.0	-	-	-	-	-
CLTR1	CysLT₁		Leukotriene	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	3	-	Gq/11	2	-	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CLTR1	CysLT₁		Leukotriene	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	3	-	Gi/o	2	nc	1'	2'	nc	0	100	89	0	-	-	-	-	-	Gz	0	-	-	98	98	-	-	100	92	98	85	84	80	89	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CLTR2	CysLT₂		Leukotriene	A	-	Bouvier	GEMTA	3	12		LTB₄	Phys	-	2	3	1	Gq/11	3	nc	3'	1'	2'	0	90	100	94	log(Emax/EC50)	0.0	8.4	9.3	8.8	G15	0	-	-	74	71	-	-	90	73	80	91	90	94	100	94	87	log(Emax/EC50)	0.0	-	-	6.9	6.6	-	-	8.4	6.8	7.5	8.5	8.4	8.7	9.3	8.8	8.1
CLTR2	CysLT₂		Leukotriene	A	-	Inoue	TGF𝛼	5	1		LTD₄	Phys	-	2	3	1	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.2	-	-	-	-	-
CLTR2	CysLT₂		Leukotriene	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	3	1	Gq/11	2	-	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CLTR2	CysLT₂		Leukotriene	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	3	1	Gq/11	3	nc	3'	1'	2'	0	90	100	94	-	-	-	-	-	G15	0	-	-	74	71	-	-	90	73	80	91	90	94	100	94	87	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OXER1	OXE		Leukotriene	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OXER1	OXE		Leukotriene	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LPAR1	LPA₁		Lysophospholipid (LPA)	A	-	Bouvier	GEMTA	3	12		2-oleoyl-LPA	Phys	-	2	3	2	Gi/o	3	nc	1'	3'	2'	0	100	73	93	log(Emax/EC50)	0.0	8.3	6.1	7.8	Gi1	0	-	-	100	0	-	-	0	95	0	73	66	55	69	0	93	log(Emax/EC50)	0.0	-	-	8.3	0.0	-	-	0.0	7.9	0.0	6.1	5.5	4.6	5.8	0.0	7.8
LPAR1	LPA₁		Lysophospholipid (LPA)	A	-	Inoue	TGF𝛼	5	1		LPA	Phys	-	2	3	2	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.0	-	-	-	-	-
LPAR1	LPA₁		Lysophospholipid (LPA)	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	3	2	Gi/o	3	-	1'	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LPAR1	LPA₁		Lysophospholipid (LPA)	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	3	2	Gi/o	3	nc	1'	3'	2'	0	100	73	93	-	-	-	-	-	Gi1	0	-	-	100	0	-	-	0	95	0	73	66	55	69	0	93	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LPAR2	LPA₂		Lysophospholipid (LPA)	A	-	Bouvier	GEMTA	3	12		2-oleoyl-LPA	Phys	-	2	3	2	Gi/o	3	nc	1'	3'	2'	0	100	81	97	log(Emax/EC50)	0.0	8.5	6.9	8.2	GoB	0	-	-	94	95	-	-	85	91	100	80	78	81	73	0	97	log(Emax/EC50)	0.0	-	-	8.0	8.0	-	-	7.2	7.7	8.5	6.7	6.6	6.9	6.1	0.0	8.2
LPAR2	LPA₂		Lysophospholipid (LPA)	A	-	Inoue	TGF𝛼	5	1		LPA	Phys	-	2	3	2	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.6	-	-	-	-	-
LPAR2	LPA₂		Lysophospholipid (LPA)	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	3	2	Gi/o	3	-	1'	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LPAR2	LPA₂		Lysophospholipid (LPA)	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	3	2	Gi/o	3	nc	1'	3'	2'	0	100	81	97	-	-	-	-	-	GoB	0	-	-	94	95	-	-	85	91	100	80	78	81	73	0	97	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LPAR3	LPA₃		Lysophospholipid (LPA)	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	1	-	Gi/o	2	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LPAR3	LPA₃		Lysophospholipid (LPA)	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	1	-	Gi/o	2	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LPAR4	LPA₄		Lysophospholipid (LPA)	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	1	1	1	Gs	4	1'	1'	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LPAR4	LPA₄		Lysophospholipid (LPA)	A	-	GproteinDb	merged data	-	-	-	-	-	1	1	1	1	Gs	4	1'	1'	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LPAR5	LPA₅		Lysophospholipid (LPA)	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	-	1	1	Gq/11	2	-	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LPAR5	LPA₅		Lysophospholipid (LPA)	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	1	1	Gq/11	2	-	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LPAR6	LPA₆		Lysophospholipid (LPA)	A	-	Roth	TRUPATH	1	15		LPA	Phys	2	2	-	2	Gs	3	1'	3'	nc	2'	100	9	0	10	log(Emax/EC50)	75.4	7.1	0.0	7.4	G13	0	75	0	78	85	72	87	89	95	96	0	0	-	0	98	100	log(Emax/EC50)	0.0	5.6	0.0	5.7	6.2	5.3	6.4	6.6	7.0	7.1	0.0	0.0	-	0.0	7.2	7.4
LPAR6	LPA₆		Lysophospholipid (LPA)	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	2	2	-	2	Gs	3	1'	1'	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LPAR6	LPA₆		Lysophospholipid (LPA)	A	-	GproteinDb	merged data	-	-	-	-	-	2	2	-	2	Gs	3	1'	3'	nc	2'	100	9	0	10	-	-	-	-	-	G13	0	75	0	78	85	72	87	89	95	96	0	0	-	0	98	100	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
S1PR1	S1P₁		Lysophospholipid (S1P)	A	-	Bouvier	GEMTA	3	12		sphingosine 1-phosphate	Phys	-	2	1	1	Gi/o	3	nc	1'	3'	2'	0	100	79	86	log(Emax/EC50)	0.0	7.3	5.8	6.3	Gi1	0	-	-	100	96	-	-	0	91	95	0	0	0	79	86	86	log(Emax/EC50)	0.0	-	-	7.3	7.0	-	-	0.0	6.6	7.0	0.0	0.0	0.0	5.8	6.3	6.3
S1PR1	S1P₁		Lysophospholipid (S1P)	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	1	1	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
S1PR1	S1P₁		Lysophospholipid (S1P)	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	1	1	Gi/o	3	nc	1'	3'	2'	0	100	79	86	-	-	-	-	-	Gi1	0	-	-	100	96	-	-	0	91	95	0	0	0	79	86	86	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
S1PR2	S1P₂		Lysophospholipid (S1P)	A	-	Inoue	TGF𝛼	5	1		sphingosine 1-phosphate	Phys	1	-	2	1	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.2	-	-	-	-	-
S1PR2	S1P₂		Lysophospholipid (S1P)	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	-	2	1	Gs	3	1'	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
S1PR2	S1P₂		Lysophospholipid (S1P)	A	-	GproteinDb	merged data	-	-	-	-	-	1	-	2	1	Gs	3	1'	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
S1PR3	S1P₃		Lysophospholipid (S1P)	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	1	1	Gi/o	3	-	1'	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
S1PR3	S1P₃		Lysophospholipid (S1P)	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	1	1	Gi/o	3	-	1'	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
S1PR4	S1P₄		Lysophospholipid (S1P)	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	1	G12/13	2	-	1'	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
S1PR4	S1P₄		Lysophospholipid (S1P)	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	1	G12/13	2	-	1'	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
S1PR5	S1P₅		Lysophospholipid (S1P)	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	-	1	Gi/o	2	-	1'	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
S1PR5	S1P₅		Lysophospholipid (S1P)	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	1	Gi/o	2	-	1'	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CNR1	CB₁		Cannabinoid	A	-	Bouvier	GEMTA	3	12		WIN55212-2	Surr	3	5	2	3	Gq/11	3	nc	2'	1'	3'	0	100	100	91	log(Emax/EC50)	0.0	7.6	7.6	6.9	Gi1	0	-	-	100	93	-	-	92	97	99	0	0	48	100	91	88	log(Emax/EC50)	0.0	-	-	7.6	7.1	-	-	7.0	7.4	7.5	0.0	0.0	3.6	7.6	6.9	6.7
CNR1	CB₁		Cannabinoid	A	-	Lambert	RGB-GDP	0	6	-	CP55940	Surr	3	5	2	3	Gi/o	4	3'	1'	4'	2'	37	100	18	43	Efficacy	0.02	0.06	0.01	0.02	Gi1	37	-	-	100	-	-	-	-	-	-	18	-	-	-	43	-	Efficacy	0.02	-	-	0.06	-	-	-	-	-	-	0.01	-	-	-	0.02	-
CNR1	CB₁		Cannabinoid	A	-	Lambert	RGB-GDP	0	6	-	None (constitutive activity)	-	3	5	2	3	Gi/o	3	3'	1'	nc	2'	34	100	0	41	Econstitutive	0.02	0.06	0.00	0.02	Gi1	34	-	-	100	-	-	-	-	-	-	0	-	-	-	41	-	Econstitutive	0.02	-	-	0.06	-	-	-	-	-	-	0.00	-	-	-	0.02	-
CNR1	CB₁		Cannabinoid	A	-	Martemyanov	FreeGβγ-Nluc	2	5		anandamide	Phys	3	5	2	3	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	0.1	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.1	-	0.0	-	-	0.0	-	0.0
CNR1	CB₁		Cannabinoid	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	3	5	2	3	Gi/o	2	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CNR1	CB₁		Cannabinoid	A	-	GproteinDb	merged data	-	-	-	-	-	3	5	2	3	Gi/o	4	4'	1'	3'	2'	18	100	30	44	-	-	-	-	-	Gi1	18	-	-	100	93	-	-	92	98	99	4	0	48	50	58	44	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CNR2	CB₂		Cannabinoid	A	-	Bouvier	GEMTA	3	12		WIN55212-2	Surr	1	2	1	-	Gi/o	2	nc	1'	2'	nc	0	100	60	0	log(Emax/EC50)	0.0	8.9	5.4	0.0	Gi1	0	-	-	100	98	-	-	93	91	97	0	0	0	60	0	0	log(Emax/EC50)	0.0	-	-	8.9	8.7	-	-	8.3	8.1	8.7	0.0	0.0	0.0	5.4	0.0	0.0
CNR2	CB₂		Cannabinoid	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	2	1	-	Gi/o	2	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CNR2	CB₂		Cannabinoid	A	-	GproteinDb	merged data	-	-	-	-	-	1	2	1	-	Gi/o	2	nc	1'	2'	nc	0	100	60	0	-	-	-	-	-	Gi1	0	-	-	100	98	-	-	93	91	97	0	0	0	60	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR18	GPR18		GPR18, GPR55 and GPR119	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	1	1	-	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
GPR18	GPR18		GPR18, GPR55 and GPR119	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	1	-	Gq/11	2	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR18	GPR18		GPR18, GPR55 and GPR119	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	1	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR55	GPR55		GPR18, GPR55 and GPR119	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	-	1	1	Gq/11	2	-	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR55	GPR55		GPR18, GPR55 and GPR119	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	1	1	Gq/11	2	-	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GP119	GPR119		GPR18, GPR55 and GPR119	A	-	Inoue	TGF𝛼	5	1		GSK-1292263	Surr	1	-	1	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.3	-	-	-	-	-
GP119	GPR119		GPR18, GPR55 and GPR119	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	-	1	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GP119	GPR119		GPR18, GPR55 and GPR119	A	-	GproteinDb	merged data	-	-	-	-	-	1	-	1	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PTAFR	PAF		Platelet-activating factor	A	-	Inoue	TGF𝛼	5	1		PAF	Phys	-	1	2	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.7	-	-	-	-	-
PTAFR	PAF		Platelet-activating factor	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	2	-	Gq/11	2	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PTAFR	PAF		Platelet-activating factor	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	2	-	Gq/11	2	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PD2R	DP₁		Prostanoid	A	-	Inoue	NanoBiT-G	1	8		PGD₂	Phys	3	1	2	1	Gi/o	4	2'	1'	3'	4'	96	100	92	90	log(Emax/EC50)	7.1	7.4	6.8	6.7	Gi1	-	96	-	100	0	0	-	-	79	-	92	-	-	-	90	0	log(Emax/EC50)	-	7.1	-	7.4	0.0	0.0	-	-	5.9	-	6.8	-	-	-	6.7	0.0
PD2R	DP₁		Prostanoid	A	-	Martemyanov	FreeGβγ-Nluc	2	5		PGD₂	Phys	3	1	2	1	Gs	2	1'	nc	2'	nc	100	0	22	0	Activation rate (s^-1)	0.9	0.0	0.2	0.0	GsL	100	-	-	-	-	-	-	-	0	-	0	-	-	22	-	0	Activation rate (s^-1)	0.9	-	-	-	-	-	-	-	0.0	-	0.0	-	-	0.2	-	0.0
PD2R	DP₁		Prostanoid	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	3	1	2	1	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PD2R	DP₁		Prostanoid	A	-	GproteinDb	merged data	-	-	-	-	-	3	1	2	1	Gs	4	1'	3'	2'	4'	98	50	57	45	-	-	-	-	-	Gi1	100	96	-	100	0	0	-	-	40	-	46	-	-	22	90	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PD2R2	DP₂		Prostanoid	A	-	Martemyanov	FreeGβγ-Nluc	2	5		PGD₂	Phys	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	0.6	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.6	-	0.0	-	-	0.0	-	0.0
PD2R2	DP₂		Prostanoid	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PD2R2	DP₂		Prostanoid	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PE2R1	EP₁		Prostanoid	A	-	Bouvier	GEMTA	3	12		PGE₂	Phys	-	4	5	2	Gq/11	3	nc	3'	1'	2'	0	73	100	93	log(Emax/EC50)	0.0	6.7	9.2	8.6	G15	0	-	-	57	64	-	-	0	73	67	84	85	78	100	93	76	log(Emax/EC50)	0.0	-	-	5.2	5.9	-	-	0.0	6.7	6.2	7.7	7.8	7.1	9.2	8.6	7.0
PE2R1	EP₁		Prostanoid	A	-	Inoue	NanoBiT-G	1	8		PGE₂	Phys	-	4	5	2	G12/13	3	nc	2'	3'	1'	0	84	74	100	log(Emax/EC50)	0.0	6.8	6.0	8.1	G12	-	0	-	79	79	84	-	-	0	-	74	-	-	-	100	0	log(Emax/EC50)	-	0.0	-	6.4	6.4	6.8	-	-	0.0	-	6.0	-	-	-	8.1	0.0
PE2R1	EP₁		Prostanoid	A	-	Martemyanov	FreeGβγ-Nluc	2	5		PGE₂	Phys	-	4	5	2	Gq/11	2	nc	2'	1'	nc	0	22	100	0	Activation rate (s^-1)	0.0	0.1	0.6	0.0	Gq	0	-	-	-	-	-	-	-	22	-	100	-	-	67	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.1	-	0.6	-	-	0.4	-	0.0
PE2R1	EP₁		Prostanoid	A	-	Inoue	TGF𝛼	5	1		PGE₂	Phys	-	4	5	2	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.5	-	-	-	-	-
PE2R1	EP₁		Prostanoid	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	4	5	2	Gq/11	2	-	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PE2R1	EP₁		Prostanoid	A	-	GproteinDb	merged data	-	-	-	-	-	-	4	5	2	Gq/11	3	nc	3'	1'	2'	0	60	91	64	-	-	-	-	-	G12	0	0	-	68	72	84	-	0	32	67	86	85	78	84	96	25	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PE2R2	EP₂		Prostanoid	A	-	Bouvier	GEMTA	3	12		PGE₂	Phys	4	2	1	2	Gs	4	1'	4'	2'	3'	100	53	60	56	log(Emax/EC50)	9.3	4.9	5.6	5.2	GsL	100	-	-	0	0	-	-	53	0	0	0	0	0	60	56	0	log(Emax/EC50)	9.3	-	-	0.0	0.0	-	-	4.9	0.0	0.0	0.0	0.0	0.0	5.6	5.2	0.0
PE2R2	EP₂		Prostanoid	A	-	Inoue	NanoBiT-G	1	8		PGE₂	Phys	4	2	1	2	Gi/o	3	2'	1'	nc	3'	97	100	0	82	log(Emax/EC50)	7.4	7.6	0.0	6.2	Gi1	-	97	-	100	82	0	-	-	85	-	0	-	-	-	82	78	log(Emax/EC50)	-	7.4	-	7.6	6.3	0.0	-	-	6.5	-	0.0	-	-	-	6.2	6.0
PE2R2	EP₂		Prostanoid	A	-	Martemyanov	FreeGβγ-Nluc	2	5		PGE₂	Phys	4	2	1	2	Gs	1	1'	nc	2'	nc	100	0	2	0	Activation rate (s^-1)	1.5	0.0	0.0	0.0	GsL	100	-	-	-	-	-	-	-	0	-	0	-	-	2	-	0	Activation rate (s^-1)	1.5	-	-	-	-	-	-	-	0.0	-	0.0	-	-	0.0	-	0.0
PE2R2	EP₂		Prostanoid	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	4	2	1	2	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PE2R2	EP₂		Prostanoid	A	-	GproteinDb	merged data	-	-	-	-	-	4	2	1	2	Gs	4	1'	2'	4'	3'	99	51	21	46	-	-	-	-	-	GsL	100	97	-	50	41	0	-	53	28	0	0	0	0	31	69	26	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PE2R3	EP₃		Prostanoid	A	-	Bouvier	GEMTA	3	12		PGE₂	Phys	-	4	3	3	Gi/o	3	nc	1'	3'	2'	0	100	79	85	log(Emax/EC50)	0.0	9.5	7.5	8.0	Gi1	0	-	-	100	96	-	-	100	97	96	0	0	56	79	0	85	log(Emax/EC50)	0.0	-	-	9.4	9.1	-	-	9.5	9.1	9.1	0.0	0.0	5.3	7.5	0.0	8.0
PE2R3	EP₃		Prostanoid	A	-	Inoue	NanoBiT-G	1	8		PGE₂	Phys	-	4	3	3	Gi/o	2	nc	1'	nc	2'	0	100	0	89	log(Emax/EC50)	0.0	9.1	0.0	8.1	GoA	-	0	-	96	92	88	-	-	100	-	0	-	-	-	72	89	log(Emax/EC50)	-	0.0	-	8.8	8.4	8.0	-	-	9.1	-	0.0	-	-	-	6.6	8.1
PE2R3	EP₃		Prostanoid	A	-	Martemyanov	FreeGβγ-Nluc	2	5		PGE₂	Phys	-	4	3	3	Gi/o	2	nc	1'	3'	2'	0	100	2	4	Activation rate (s^-1)	0.0	1.4	0.0	0.1	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	2	-	4	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	1.4	-	0.0	-	-	0.0	-	0.1
PE2R3	EP₃		Prostanoid	A	-	Inoue	TGF𝛼	5	1		PGE₂	Phys	-	4	3	3	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.5	-	-	-	-	-
PE2R3	EP₃		Prostanoid	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	4	3	3	Gi/o	2	-	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PE2R3	EP₃		Prostanoid	A	-	GproteinDb	merged data	-	-	-	-	-	-	4	3	3	Gi/o	3	nc	1'	3'	2'	0	100	27	59	-	-	-	-	-	Gz	0	0	-	98	94	88	-	100	99	96	0	0	56	40	36	59	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PE2R4	EP₄		Prostanoid	A	-	Bouvier	GEMTA	3	12		PGE₂	Phys	4	4	2	3	Gs	4	1'	2'	3'	4'	100	85	83	83	log(Emax/EC50)	10.5	8.9	8.7	8.7	GsL	100	-	-	85	79	-	-	69	0	67	0	0	0	83	83	75	log(Emax/EC50)	10.5	-	-	8.9	8.3	-	-	7.2	0.0	7.0	0.0	0.0	0.0	8.7	8.7	7.9
PE2R4	EP₄		Prostanoid	A	-	Inoue	NanoBiT-G	1	8		PGE₂	Phys	4	4	2	3	G12/13	3	3'	2'	nc	1'	82	90	0	100	log(Emax/EC50)	7.1	7.8	0.0	8.6	G12	-	82	-	90	90	0	-	-	81	-	0	-	-	-	100	70	log(Emax/EC50)	-	7.1	-	7.8	7.7	0.0	-	-	7.0	-	0.0	-	-	-	8.6	6.1
PE2R4	EP₄		Prostanoid	A	-	Martemyanov	FreeGβγ-Nluc	2	5		PGE₂	Phys	4	4	2	3	Gs	4	1'	3'	2'	4'	100	6	11	4	Activation rate (s^-1)	1.7	0.1	0.2	0.1	GsL	100	-	-	-	-	-	-	-	6	-	0	-	-	11	-	4	Activation rate (s^-1)	1.7	-	-	-	-	-	-	-	0.1	-	0.0	-	-	0.2	-	0.1
PE2R4	EP₄		Prostanoid	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	4	4	2	3	Gs	2	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PE2R4	EP₄		Prostanoid	A	-	GproteinDb	merged data	-	-	-	-	-	4	4	2	3	Gs	4	1'	3'	4'	2'	94	60	31	62	-	-	-	-	-	GsL	100	82	-	88	84	0	-	69	29	67	0	0	0	47	92	50	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PF2R	FP		Prostanoid	A	-	Bouvier	GEMTA	3	12		PGD₂	Phys	1	1	4	2	Gq/11	3	nc	3'	1'	2'	0	78	100	96	log(Emax/EC50)	0.0	6.6	8.5	8.2	G15	0	-	-	63	0	-	-	78	69	72	96	98	93	100	89	96	log(Emax/EC50)	0.0	-	-	5.3	0.0	-	-	6.6	5.9	6.1	8.2	8.3	7.9	8.5	7.5	8.2
PF2R	FP		Prostanoid	A	-	Inoue	NanoBiT-G	1	8		PGF2-1-ethanolamide	Surr	1	1	4	2	G12/13	2	nc	nc	2'	1'	0	0	96	100	log(Emax/EC50)	0.0	0.0	6.1	6.4	G12	-	0	-	0	0	0	-	-	0	-	96	-	-	-	100	98	log(Emax/EC50)	-	0.0	-	0.0	0.0	0.0	-	-	0.0	-	6.1	-	-	-	6.4	6.2
PF2R	FP		Prostanoid	A	-	Inoue	TGF𝛼	5	1		PGF_2α	Phys	1	1	4	2	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.6	-	-	-	-	-
PF2R	FP		Prostanoid	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	1	4	2	Gq/11	2	2'	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PF2R	FP		Prostanoid	A	-	GproteinDb	merged data	-	-	-	-	-	1	1	4	2	Gq/11	3	nc	3'	1'	2'	0	39	98	98	-	-	-	-	-	G15	0	0	-	32	0	0	-	78	34	72	96	98	93	100	94	97	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PI2R	IP		Prostanoid	A	-	Inoue	NanoBiT-G	1	8		iloprost	Surr	2	2	3	1	G12/13	4	2'	3'	4'	1'	99	98	96	100	log(Emax/EC50)	8.6	8.5	8.3	8.7	G12	-	99	-	98	97	0	-	-	83	-	96	-	-	-	100	91	log(Emax/EC50)	-	8.6	-	8.5	8.4	0.0	-	-	7.2	-	8.3	-	-	-	8.7	7.9
PI2R	IP		Prostanoid	A	-	Inoue	TGF𝛼	5	1		iloprost	Surr	2	2	3	1	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.0	-	-	-	-	-
PI2R	IP		Prostanoid	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	2	2	3	1	Gs	3	1'	2'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PI2R	IP		Prostanoid	A	-	GproteinDb	merged data	-	-	-	-	-	2	2	3	1	G12/13	4	2'	3'	4'	1'	99	98	96	100	-	-	-	-	-	G12	-	99	-	98	97	0	-	-	83	-	96	-	-	-	100	91	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TA2R	TP		Prostanoid	A	-	Inoue	NanoBiT-G	1	8		U46619	Surr	-	-	5	3	G12/13	2	nc	nc	2'	1'	0	0	82	100	log(Emax/EC50)	0.0	0.0	7.2	8.7	G12	-	0	-	0	0	0	-	-	0	-	82	-	-	-	100	95	log(Emax/EC50)	-	0.0	-	0.0	0.0	0.0	-	-	0.0	-	7.2	-	-	-	8.7	8.3
TA2R	TP		Prostanoid	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	-	5	3	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	-	0.00	-
TA2R	TP		Prostanoid	A	-	Lambert	RGB-GDP	0	6		U46619	Surr	-	-	5	3	Gq/11	2	nc	nc	1'	2'	0	0	100	43	Efficacy	0.00	0.00	0.02	0.01	Gq	0	-	-	0	-	-	-	-	-	-	100	-	-	-	43	-	Efficacy	0.00	-	-	0.00	-	-	-	-	-	-	0.02	-	-	-	0.01	-
TA2R	TP		Prostanoid	A	-	Martemyanov	FreeGβγ-Nluc	2	5		PGH₂	Phys	-	-	5	3	G12/13	2	nc	nc	2'	1'	0	0	43	100	Activation rate (s^-1)	0.0	0.0	0.2	0.5	G13	0	-	-	-	-	-	-	-	0	-	43	-	-	18	-	100	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.0	-	0.2	-	-	0.1	-	0.5
TA2R	TP		Prostanoid	A	-	Inoue	TGF𝛼	5	1		U46619	Surr	-	-	5	3	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.8	-	-	-	-	-
TA2R	TP		Prostanoid	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	-	5	3	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TA2R	TP		Prostanoid	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	5	3	G12/13	2	nc	nc	2'	1'	0	0	56	61	-	-	-	-	-	G13	0	0	-	0	0	0	-	-	0	-	56	-	-	18	48	98	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MTR1A	MT₁		Melatonin	A	-	Bouvier	GEMTA	3	12		melatonin	Phys	-	3	3	-	Gi/o	2	nc	1'	2'	nc	0	100	89	0	log(Emax/EC50)	0.0	10.1	9.0	0.0	Gi1	0	-	-	100	99	-	-	0	98	99	0	0	0	89	0	0	log(Emax/EC50)	0.0	-	-	10.1	10.0	-	-	0.0	9.9	10.0	0.0	0.0	0.0	9.0	0.0	0.0
MTR1A	MT₁		Melatonin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		melatonin	Phys	-	3	3	-	Gi/o	2	nc	1'	2'	nc	0	100	6	0	Activation rate (s^-1)	0.0	1.2	0.1	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	6	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	1.2	-	0.0	-	-	0.1	-	0.0
MTR1A	MT₁		Melatonin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	3	3	-	Gi/o	2	-	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MTR1A	MT₁		Melatonin	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	3	-	Gi/o	2	nc	1'	2'	nc	0	100	48	0	-	-	-	-	-	Gi1	0	-	-	100	99	-	-	0	99	99	0	0	0	48	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MTR1B	MT₂		Melatonin	A	-	Bouvier	GEMTA	3	12		melatonin	Phys	-	3	1	-	Gi/o	2	nc	1'	2'	nc	0	100	76	0	log(Emax/EC50)	0.0	8.8	6.7	0.0	Gi1	0	-	-	100	98	-	-	0	91	97	0	0	0	76	0	0	log(Emax/EC50)	0.0	-	-	8.8	8.7	-	-	0.0	8.0	8.6	0.0	0.0	0.0	6.7	0.0	0.0
MTR1B	MT₂		Melatonin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		melatonin	Phys	-	3	1	-	Gi/o	1	nc	1'	2'	nc	0	100	1	0	Activation rate (s^-1)	0.0	0.6	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	1	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.6	-	0.0	-	-	0.0	-	0.0
MTR1B	MT₂		Melatonin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	3	1	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MTR1B	MT₂		Melatonin	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	1	-	Gi/o	2	nc	1'	2'	nc	0	100	38	0	-	-	-	-	-	Gi1	0	-	-	100	98	-	-	0	96	97	0	0	0	38	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AA1R	A₁		Adenosine	A	-	Bouvier	GEMTA	3	12		adenosine	Phys	1	5	3	1	Gq/11	3	nc	2'	1'	3'	0	94	100	74	log(Emax/EC50)	0.0	6.2	6.6	4.9	G15	0	-	-	86	85	-	-	86	94	93	0	0	0	100	74	0	log(Emax/EC50)	0.0	-	-	5.7	5.6	-	-	5.7	6.2	6.2	0.0	0.0	0.0	6.6	4.9	0.0
AA1R	A₁		Adenosine	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	1	5	3	1	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Econstitutive	0.00	0.10	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.10	-	-	-	-	-	-	0.00	-	-	-	0.00	-
AA1R	A₁		Adenosine	A	-	Lambert	RGB-GDP	0	6		adenosine	Phys	1	5	3	1	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Efficacy	0.00	0.05	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Efficacy	0.00	-	-	0.05	-	-	-	-	-	-	0.00	-	-	-	0.00	-
AA1R	A₁		Adenosine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		adenosine	Phys	1	5	3	1	Gi/o	2	nc	1'	2'	nc	0	100	13	0	Activation rate (s^-1)	0.0	5.4	0.7	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	13	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	5.4	-	0.0	-	-	0.7	-	0.0
AA1R	A₁		Adenosine	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	5	3	1	Gi/o	3	2'	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AA1R	A₁		Adenosine	A	-	GproteinDb	merged data	-	-	-	-	-	1	5	3	1	Gi/o	3	nc	1'	2'	3'	0	98	28	18	-	-	-	-	-	GoA	0	-	-	95	85	-	-	86	97	93	0	0	0	56	25	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AA2AR	A_2A		Adenosine	A	-	Bouvier	GEMTA	3	12		adenosine	Phys	3	1	3	1	Gs	3	1'	nc	3'	2'	100	0	96	99	log(Emax/EC50)	5.8	0.0	5.6	5.8	GsL	100	-	-	0	0	-	-	0	0	0	0	0	0	96	99	94	log(Emax/EC50)	5.8	-	-	0.0	0.0	-	-	0.0	0.0	0.0	0.0	0.0	0.0	5.6	5.8	5.5
AA2AR	A_2A		Adenosine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		adenosine	Phys	3	1	3	1	Gs	3	1'	3'	2'	nc	100	7	38	0	Activation rate (s^-1)	1.6	0.1	0.6	0.0	GsL	100	-	-	-	-	-	-	-	7	-	0	-	-	38	-	0	Activation rate (s^-1)	1.6	-	-	-	-	-	-	-	0.1	-	0.0	-	-	0.6	-	0.0
AA2AR	A_2A		Adenosine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	3	1	3	1	Gs	2	1'	-	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AA2AR	A_2A		Adenosine	A	-	GproteinDb	merged data	-	-	-	-	-	3	1	3	1	Gs	4	1'	4'	2'	3'	100	4	67	50	-	-	-	-	-	GsL	100	-	-	0	0	-	-	0	4	0	0	0	0	67	99	47	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AA2BR	A_2B		Adenosine	A	-	Bouvier	GEMTA	3	12		adenosine	Phys	3	1	3	1	Gs	2	1'	nc	2'	nc	100	0	100	0	log(Emax/EC50)	6.0	0.0	6.0	0.0	GsL	100	-	-	0	0	-	-	0	0	0	0	0	0	100	0	0	log(Emax/EC50)	6.0	-	-	0.0	0.0	-	-	0.0	0.0	0.0	0.0	0.0	0.0	6.0	0.0	0.0
AA2BR	A_2B		Adenosine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		adenosine	Phys	3	1	3	1	Gq/11	4	2'	3'	1'	4'	78	17	100	10	Activation rate (s^-1)	0.7	0.2	0.9	0.1	G15	78	-	-	-	-	-	-	-	17	-	0	-	-	100	-	10	Activation rate (s^-1)	0.7	-	-	-	-	-	-	-	0.2	-	0.0	-	-	0.9	-	0.1
AA2BR	A_2B		Adenosine	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	3	1	3	1	Gs	2	1'	-	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AA2BR	A_2B		Adenosine	A	-	GproteinDb	merged data	-	-	-	-	-	3	1	3	1	Gq/11	4	2'	3'	1'	4'	89	8	100	5	-	-	-	-	-	G15	89	-	-	0	0	-	-	0	8	0	0	0	0	100	0	5	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AA3R	A₃		Adenosine	A	-	Bouvier	GEMTA	3	12		adenosine	Phys	-	3	2	-	Gq/11	2	nc	2'	1'	nc	0	94	100	0	log(Emax/EC50)	0.0	6.6	7.1	0.0	G15	0	-	-	94	92	-	-	0	71	82	0	0	0	100	0	0	log(Emax/EC50)	0.0	-	-	6.6	6.5	-	-	0.0	5.0	5.8	0.0	0.0	0.0	7.1	0.0	0.0
AA3R	A₃		Adenosine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		adenosine	Phys	-	3	2	-	Gq/11	2	nc	2'	1'	nc	0	50	100	0	Activation rate (s^-1)	0.0	0.1	0.3	0.0	G15	0	-	-	-	-	-	-	-	50	-	0	-	-	100	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.1	-	0.0	-	-	0.3	-	0.0
AA3R	A₃		Adenosine	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	3	2	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AA3R	A₃		Adenosine	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	2	-	Gq/11	2	nc	2'	1'	nc	0	72	100	0	-	-	-	-	-	G15	0	-	-	94	92	-	-	0	60	82	0	0	0	100	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
P2RY1	P2Y₁		P2Y	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	1	-	Gq/11	2	-	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
P2RY1	P2Y₁		P2Y	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	1	-	Gq/11	2	-	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
P2RY2	P2Y₂		P2Y	A	-	Bouvier	GEMTA	3	12		UTP	Phys	-	2	2	1	Gq/11	2	nc	2'	1'	nc	0	96	100	0	log(Emax/EC50)	0.0	5.1	5.3	0.0	G15	0	-	-	95	93	-	-	94	92	96	91	90	88	100	0	0	log(Emax/EC50)	0.0	-	-	5.1	5.0	-	-	5.0	4.9	5.1	4.8	4.8	4.7	5.3	0.0	0.0
P2RY2	P2Y₂		P2Y	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	2	1	Gq/11	3	-	2'	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
P2RY2	P2Y₂		P2Y	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	2	1	Gq/11	2	nc	2'	1'	nc	0	96	100	0	-	-	-	-	-	G15	0	-	-	95	93	-	-	94	92	96	91	90	88	100	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
P2RY4	P2Y₄		P2Y	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	-	1	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
P2RY4	P2Y₄		P2Y	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	1	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
P2RY6	P2Y₆		P2Y	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	-	1	1	Gq/11	2	-	-	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
P2RY6	P2Y₆		P2Y	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	1	1	Gq/11	2	-	-	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
P2Y11	P2Y₁₁		P2Y	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	-	1	-	Gq/11	2	2'	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
P2Y11	P2Y₁₁		P2Y	A	-	GproteinDb	merged data	-	-	-	-	-	1	-	1	-	Gq/11	2	2'	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
P2Y13	P2Y₁₃		P2Y	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
P2Y13	P2Y₁₃		P2Y	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
P2Y14	P2Y₁₄		P2Y	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
P2Y14	P2Y₁₄		P2Y	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPBAR	GPBA		Bile acid	A	-	Bouvier	GEMTA	3	12		lithocholic acid	Phys	3	-	-	-	Gs	1	1'	nc	nc	nc	100	0	0	0	log(Emax/EC50)	5.9	0.0	0.0	0.0	GsL	100	-	-	0	0	-	-	0	0	0	0	0	0	0	0	0	log(Emax/EC50)	5.9	-	-	0.0	0.0	-	-	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
GPBAR	GPBA		Bile acid	A	-	Martemyanov	FreeGβγ-Nluc	2	5		deoxycholic acid	Phys	3	-	-	-	Gs	1	1'	nc	nc	nc	100	0	0	0	Activation rate (s^-1)	0.3	0.0	0.0	0.0	GsL	100	-	-	-	-	-	-	-	0	-	0	-	-	0	-	0	Activation rate (s^-1)	0.3	-	-	-	-	-	-	-	0.0	-	0.0	-	-	0.0	-	0.0
GPBAR	GPBA		Bile acid	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	3	-	-	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPBAR	GPBA		Bile acid	A	-	GproteinDb	merged data	-	-	-	-	-	3	-	-	-	Gs	1	1'	nc	nc	nc	100	0	0	0	-	-	-	-	-	GsL	100	-	-	0	0	-	-	0	0	0	0	0	0	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPER1	GPER		Estrogen (G protein-coupled)	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	1	-	-	Gi/o	2	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPER1	GPER		Estrogen (G protein-coupled)	A	-	GproteinDb	merged data	-	-	-	-	-	1	1	-	-	Gi/o	2	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HCAR1	HCA₁		Hydroxycarboxylic acid	A	-	Lambert	RGB-GDP	0	6	-	None (constitutive activity)	-	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Econstitutive	0.00	0.04	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.04	-	-	-	-	-	-	0.00	-	-	-	0.00	-
HCAR1	HCA₁		Hydroxycarboxylic acid	A	-	Lambert	RGB-GDP	0	6	-	L-lactic acid	Phys	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Efficacy	0.00	0.05	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Efficacy	0.00	-	-	0.05	-	-	-	-	-	-	0.00	-	-	-	0.00	-
HCAR1	HCA₁		Hydroxycarboxylic acid	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	3	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HCAR1	HCA₁		Hydroxycarboxylic acid	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HCAR2	HCA₂		Hydroxycarboxylic acid	A	-	Bouvier	GEMTA	3	12		nicotinic acid	Phys	-	4	-	1	Gi/o	2	nc	1'	nc	2'	0	100	0	82	log(Emax/EC50)	0.0	6.9	0.0	5.7	Gi1	0	-	-	100	96	-	-	92	94	96	0	0	0	0	0	82	log(Emax/EC50)	0.0	-	-	6.9	6.7	-	-	6.4	6.5	6.6	0.0	0.0	0.0	0.0	0.0	5.7
HCAR2	HCA₂		Hydroxycarboxylic acid	A	-	Lambert	RGB-GDP	0	6	-	None (constitutive activity)	-	-	4	-	1	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Econstitutive	0.00	0.05	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.05	-	-	-	-	-	-	0.00	-	-	-	0.00	-
HCAR2	HCA₂		Hydroxycarboxylic acid	A	-	Lambert	RGB-GDP	0	6	-	β-D-hydroxybutyric acid	Phys	-	4	-	1	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Efficacy	0.00	0.05	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Efficacy	0.00	-	-	0.05	-	-	-	-	-	-	0.00	-	-	-	0.00	-
HCAR2	HCA₂		Hydroxycarboxylic acid	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	4	-	1	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HCAR2	HCA₂		Hydroxycarboxylic acid	A	-	GproteinDb	merged data	-	-	-	-	-	-	4	-	1	Gi/o	2	nc	1'	nc	2'	0	100	0	27	-	-	-	-	-	Gi1	0	-	-	100	96	-	-	92	94	96	0	0	0	0	0	82	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HCAR3	HCA₃		Hydroxycarboxylic acid	A	-	Bouvier	GEMTA	3	12		3-hydroxyoctanoic acid	Phys	-	4	-	1	Gi/o	2	nc	1'	nc	2'	0	100	0	61	log(Emax/EC50)	0.0	5.3	0.0	3.2	Gi1	0	-	-	100	95	-	-	86	91	94	0	0	0	0	0	61	log(Emax/EC50)	0.0	-	-	5.3	5.0	-	-	4.5	4.8	5.0	0.0	0.0	0.0	0.0	0.0	3.2
HCAR3	HCA₃		Hydroxycarboxylic acid	A	-	Lambert	RGB-GDP	0	6	-	None (constitutive activity)	-	-	4	-	1	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Econstitutive	0.00	0.06	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.06	-	-	-	-	-	-	0.00	-	-	-	0.00	-
HCAR3	HCA₃		Hydroxycarboxylic acid	A	-	Lambert	RGB-GDP	0	6	-	nicotinic acid	Phys	-	4	-	1	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Efficacy	0.00	0.06	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Efficacy	0.00	-	-	0.06	-	-	-	-	-	-	0.00	-	-	-	0.00	-
HCAR3	HCA₃		Hydroxycarboxylic acid	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	4	-	1	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HCAR3	HCA₃		Hydroxycarboxylic acid	A	-	GproteinDb	merged data	-	-	-	-	-	-	4	-	1	Gi/o	2	nc	1'	nc	2'	0	100	0	20	-	-	-	-	-	Gi1	0	-	-	100	95	-	-	86	91	94	0	0	0	0	0	61	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OXGR1	Oxoglutarate		Oxoglutarate	A	-	Martemyanov	FreeGβγ-Nluc	2	5		α-ketoglutaric acid	Phys	-	1	2	-	Gq/11	2	nc	2'	1'	nc	0	41	100	0	Activation rate (s^-1)	0.0	0.1	0.2	0.0	Gq	0	-	-	-	-	-	-	-	41	-	100	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.1	-	0.2	-	-	0.0	-	0.0
OXGR1	Oxoglutarate		Oxoglutarate	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	2	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OXGR1	Oxoglutarate		Oxoglutarate	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	2	-	Gq/11	2	nc	2'	1'	nc	0	41	100	0	-	-	-	-	-	Gq	0	-	-	-	-	-	-	-	41	-	100	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SUCR1	Succinate		Succinate	A	-	Martemyanov	FreeGβγ-Nluc	2	5		succinic acid	Phys	-	2	1	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	0.1	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.1	-	0.0	-	-	0.0	-	0.0
SUCR1	Succinate		Succinate	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	1	-	Gi/o	2	-	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SUCR1	Succinate		Succinate	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	1	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OPN4	OPN4		Opsins	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	1	-	Gq/11	2	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OPN4	OPN4		Opsins	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	1	-	Gq/11	2	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OPN5	OPN5		Opsins	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OPN5	OPN5		Opsins	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR4	GPR4		A orphans	A	-	Bouvier	GEMTA	3	12		pH (proton)	Phys	3	3	3	2	Gs	3	1'	3'	2'	nc	100	55	76	0	log(Emax/EC50)	7.7	4.3	5.9	0.0	GsL	100	-	-	55	54	-	-	0	0	0	76	75	65	72	0	0	log(Emax/EC50)	7.7	-	-	4.3	4.2	-	-	0.0	0.0	0.0	5.9	5.8	5.0	5.6	0.0	0.0
GPR4	GPR4		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	3	3	3	2	Gs	4	1'	3'	4'	2'	100	59	46	99	Econstitutive	0.03	0.02	0.02	0.03	GsL	100	-	-	59	-	-	-	-	-	-	46	-	-	38	-	99	Econstitutive	0.03	-	-	0.02	-	-	-	-	-	-	0.02	-	-	0.01	-	0.03
GPR4	GPR4		A orphans	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	3	3	3	2	G12/13	4	1'	1'	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR4	GPR4		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	3	3	3	2	Gs	4	1'	3'	2'	4'	100	57	61	50	-	-	-	-	-	GsL	100	-	-	57	54	-	-	0	0	0	61	75	65	55	0	50	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR6	GPR6		A orphans	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	1	-	-	Gi/o	2	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR6	GPR6		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	1	1	-	-	Gi/o	2	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR12	GPR12		A orphans	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	1	-	-	Gi/o	2	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR12	GPR12		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	1	1	-	-	Gi/o	2	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR17	GPR17		A orphans	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	1	-	Gi/o	2	-	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR17	GPR17		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	1	-	Gi/o	2	-	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR19	GPR19		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
GPR19	GPR19		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR20	GPR20		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Econstitutive	0.00	0.07	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.00	-	-	0.07	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
GPR20	GPR20		A orphans	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR20	GPR20		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR21	GPR21		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	1	-	1	-	Gs	2	1'	nc	2'	nc	100	0	43	0	Econstitutive	0.03	0.00	0.01	0.00	GsL	100	-	-	0	-	-	-	-	-	-	0	-	-	43	-	0	Econstitutive	0.03	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.01	-	0.00
GPR21	GPR21		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	1	-	1	-	Gs	2	1'	nc	2'	nc	100	0	43	0	-	-	-	-	-	GsL	100	-	-	0	-	-	-	-	-	-	0	-	-	43	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR22	GPR22		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Econstitutive	0.00	0.05	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.00	-	-	0.05	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
GPR22	GPR22		A orphans	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR22	GPR22		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR25	GPR25		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	1	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Econstitutive	0.00	0.01	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.00	-	-	0.01	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
GPR25	GPR25		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR26	GPR26		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	2	1	1	-	Gs	3	1'	2'	3'	nc	100	63	47	0	Econstitutive	0.05	0.03	0.02	0.00	GsL	100	-	-	63	-	-	-	-	-	-	17	-	-	47	-	0	Econstitutive	0.05	-	-	0.03	-	-	-	-	-	-	0.01	-	-	0.02	-	0.00
GPR26	GPR26		A orphans	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	2	1	1	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR26	GPR26		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	2	1	1	-	Gs	3	1'	2'	3'	nc	100	63	47	0	-	-	-	-	-	GsL	100	-	-	63	-	-	-	-	-	-	17	-	-	47	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR27	GPR27		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	-	1	-	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
GPR27	GPR27		A orphans	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	-	1	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR27	GPR27		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	1	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR31	GPR31		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	1	-	-	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
GPR31	GPR31		A orphans	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR31	GPR31		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR32	GPR32		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	1	1	-	Gi/o	2	nc	1'	2'	nc	0	100	69	0	Econstitutive	0.00	0.05	0.04	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	69	-	0	Econstitutive	0.00	-	-	0.05	-	-	-	-	-	-	0.00	-	-	0.04	-	0.00
GPR32	GPR32		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	1	-	Gi/o	2	nc	1'	2'	nc	0	100	69	0	-	-	-	-	-	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	69	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR33	GPR33		A orphans	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR33	GPR33		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR34	GPR34		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Econstitutive	0.00	0.12	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.00	-	-	0.12	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
GPR34	GPR34		A orphans	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR34	GPR34		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR35	GPR35		A orphans	A	-	Lambert	RGB-GDP	0	6		zaprinast	Surr	-	-	-	1	G12/13	1	nc	nc	nc	1'	0	0	0	100	Efficacy	0.00	0.00	0.00	0.02	G12	0	-	-	0	-	-	-	-	-	-	0	-	-	-	100	-	Efficacy	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	-	0.02	-
GPR35	GPR35		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	-	-	1	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	-	0.00	-
GPR35	GPR35		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	-	1	G12/13	1	nc	nc	nc	1'	0	0	0	50	-	-	-	-	-	G12	0	-	-	0	-	-	-	-	-	-	0	-	-	-	50	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR37	GPR37		A orphans	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR37	GPR37		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
G37L1	GPR37L1		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	1	-	-	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
G37L1	GPR37L1		A orphans	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
G37L1	GPR37L1		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR39	GPR39		A orphans	A	-	Bouvier	GEMTA	3	12		Zn²⁺	Phys	1	1	2	2	G12/13	3	nc	2'	3'	1'	0	77	77	100	log(Emax/EC50)	0.0	3.6	3.5	4.6	G13	0	-	-	77	68	-	-	0	72	77	76	72	77	63	0	100	log(Emax/EC50)	0.0	-	-	3.5	3.1	-	-	0.0	3.3	3.6	3.5	3.3	3.5	2.9	0.0	4.6
GPR39	GPR39		A orphans	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	1	2	2	Gq/11	3	2'	-	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR39	GPR39		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	1	1	2	2	G12/13	3	nc	2'	3'	1'	0	77	77	100	-	-	-	-	-	G13	0	-	-	77	68	-	-	0	72	77	76	72	77	63	0	100	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR45	GPR45		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
GPR45	GPR45		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR52	GPR52		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	2	1	2	-	Gq/11	2	2'	nc	1'	nc	82	0	100	0	Econstitutive	0.03	0.00	0.03	0.00	G15	82	-	-	0	-	-	-	-	-	-	0	-	-	100	-	0	Econstitutive	0.03	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.03	-	0.00
GPR52	GPR52		A orphans	A	-	Martemyanov	FreeGβγ-Nluc	2	5		TP-024	Surr	2	1	2	-	Gs	3	1'	3'	2'	nc	100	47	62	0	Activation rate (s^-1)	0.2	0.1	0.1	0.0	GsL	100	-	-	-	-	-	-	-	47	-	0	-	-	62	-	0	Activation rate (s^-1)	0.2	-	-	-	-	-	-	-	0.1	-	0.0	-	-	0.1	-	0.0
GPR52	GPR52		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	2	1	2	-	Gs	3	1'	3'	2'	nc	91	24	81	0	-	-	-	-	-	GsL	91	-	-	0	-	-	-	-	47	-	0	-	-	81	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR61	GPR61		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	-	1	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	Econstitutive	0.00	0.00	0.01	0.00	G15	0	-	-	0	-	-	-	-	-	-	0	-	-	100	-	0	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.01	-	0.00
GPR61	GPR61		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	1	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	-	-	-	-	-	G15	0	-	-	0	-	-	-	-	-	-	0	-	-	100	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR62	GPR62		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	1	1	1	-	Gs	3	1'	2'	3'	nc	100	92	71	0	Econstitutive	0.02	0.02	0.01	0.00	GsL	100	-	-	92	-	-	-	-	-	-	0	-	-	71	-	0	Econstitutive	0.02	-	-	0.02	-	-	-	-	-	-	0.00	-	-	0.01	-	0.00
GPR62	GPR62		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	1	1	1	-	Gs	3	1'	2'	3'	nc	100	92	71	0	-	-	-	-	-	GsL	100	-	-	92	-	-	-	-	-	-	0	-	-	71	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR63	GPR63		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
GPR63	GPR63		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PSYR	GPR65		A orphans	A	-	Bouvier	GEMTA	3	12		pH (proton)	Phys	3	2	-	2	G12/13	3	2'	3'	nc	1'	94	74	0	100	log(Emax/EC50)	6.7	5.3	0.0	7.1	G13	94	-	-	0	0	-	-	0	0	74	0	0	0	0	0	100	log(Emax/EC50)	6.7	-	-	0.0	0.0	-	-	0.0	0.0	5.3	0.0	0.0	0.0	0.0	0.0	7.1
PSYR	GPR65		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	3	2	-	2	G12/13	3	2'	3'	nc	1'	52	27	0	100	Econstitutive	0.02	0.01	0.00	0.05	G13	52	-	-	27	-	-	-	-	-	-	0	-	-	0	-	100	Econstitutive	0.02	-	-	0.01	-	-	-	-	-	-	0.00	-	-	0.00	-	0.05
PSYR	GPR65		A orphans	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	3	2	-	2	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PSYR	GPR65		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	3	2	-	2	G12/13	3	2'	3'	nc	1'	73	50	0	100	-	-	-	-	-	G13	73	-	-	14	0	-	-	0	0	74	0	0	0	0	0	100	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OGR1	GPR68		A orphans	A	-	Bouvier	GEMTA	3	12		pH (proton)	Phys	1	3	3	2	Gq/11	4	4'	3'	1'	2'	88	98	100	99	log(Emax/EC50)	6.3	7.1	7.2	7.2	Gq	88	-	-	88	87	-	-	0	92	98	100	100	98	84	92	99	log(Emax/EC50)	6.3	-	-	6.4	6.3	-	-	0.0	6.7	7.1	7.2	7.2	7.1	6.1	6.7	7.2
OGR1	GPR68		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	1	3	3	2	G12/13	3	nc	3'	2'	1'	0	41	65	100	Econstitutive	0.00	0.02	0.04	0.06	G13	0	-	-	41	-	-	-	-	-	-	65	-	-	0	-	100	Econstitutive	0.00	-	-	0.02	-	-	-	-	-	-	0.04	-	-	0.00	-	0.06
OGR1	GPR68		A orphans	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	3	3	2	Gq/11	2	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OGR1	GPR68		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	1	3	3	2	G12/13	4	4'	3'	2'	1'	44	70	82	100	-	-	-	-	-	G11	44	-	-	64	87	-	-	0	92	98	82	100	98	42	92	100	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR75	GPR75		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	1	1	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Econstitutive	0.00	0.01	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.00	-	-	0.01	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
GPR75	GPR75		A orphans	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	1	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR75	GPR75		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	1	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR78	GPR78		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	2	-	-	-	Gs	1	1'	nc	nc	nc	100	0	0	0	Econstitutive	0.02	0.00	0.00	0.00	GsL	100	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.02	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
GPR78	GPR78		A orphans	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	2	-	-	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR78	GPR78		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	2	-	-	-	Gs	1	1'	nc	nc	nc	100	0	0	0	-	-	-	-	-	GsL	100	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR82	GPR82		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	1	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Econstitutive	0.00	0.09	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.00	-	-	0.09	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
GPR82	GPR82		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR84	GPR84		A orphans	A	-	Bouvier	GEMTA	3	12		undecanoic acid	Phys	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	log(Emax/EC50)	0.0	3.8	0.0	0.0	Gz	0	-	-	88	81	-	-	100	43	0	0	0	0	0	0	0	log(Emax/EC50)	0.0	-	-	3.3	3.1	-	-	3.8	1.6	0.0	0.0	0.0	0.0	0.0	0.0	0.0
GPR84	GPR84		A orphans	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR84	GPR84		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	Gz	0	-	-	88	81	-	-	100	43	0	0	0	0	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR85	GPR85		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
GPR85	GPR85		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR87	GPR87		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	1	1	-	Gi/o	2	nc	1'	2'	nc	0	100	22	0	Econstitutive	0.00	0.13	0.03	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	22	-	-	0	-	0	Econstitutive	0.00	-	-	0.13	-	-	-	-	-	-	0.03	-	-	0.00	-	0.00
GPR87	GPR87		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	1	-	Gi/o	2	nc	1'	2'	nc	0	100	22	0	-	-	-	-	-	Gi1	0	-	-	100	-	-	-	-	-	-	22	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR88	GPR88		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	1	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Econstitutive	0.00	0.07	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.00	-	-	0.07	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
GPR88	GPR88		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GP101	GPR101		A orphans	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	-	-	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GP101	GPR101		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	1	-	-	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GP132	GPR132		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	1	-	1	Gi/o	2	nc	1'	nc	2'	0	100	0	97	Econstitutive	0.00	0.01	0.00	0.01	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	0	-	97	Econstitutive	0.00	-	-	0.01	-	-	-	-	-	-	0.00	-	-	0.00	-	0.01
GP132	GPR132		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	1	Gi/o	2	nc	1'	nc	2'	0	100	0	97	-	-	-	-	-	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	0	-	97	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GP135	GPR135		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
GP135	GPR135		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GP139	GPR139		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	1	2	1	Gi/o	3	nc	1'	2'	3'	0	100	40	24	Econstitutive	0.00	0.06	0.02	0.01	Gi1	0	-	-	100	-	-	-	-	-	-	36	-	-	40	-	24	Econstitutive	0.00	-	-	0.06	-	-	-	-	-	-	0.02	-	-	0.02	-	0.01
GP139	GPR139		A orphans	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	2	1	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GP139	GPR139		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	2	1	Gi/o	3	nc	1'	2'	3'	0	100	40	24	-	-	-	-	-	Gi1	0	-	-	100	-	-	-	-	-	-	36	-	-	40	-	24	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GP142	GPR142		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
GP142	GPR142		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GP146	GPR146		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
GP146	GPR146		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GP148	GPR148		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
GP148	GPR148		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GP149	GPR149		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
GP149	GPR149		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GP150	GPR150		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
GP150	GPR150		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GP151	GPR151		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
GP151	GPR151		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GP152	GPR152		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
GP152	GPR152		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GP153	GPR153		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
GP153	GPR153		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GP160	GPR160		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
GP160	GPR160		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GP162	GPR162		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
GP162	GPR162		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GP171	GPR171		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
GP171	GPR171		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GP173	GPR173		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
GP173	GPR173		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GP174	GPR174		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	1	1	-	1	Gs	3	1'	3'	nc	2'	100	12	0	41	Econstitutive	0.08	0.01	0.00	0.03	GsL	100	-	-	12	-	-	-	-	-	-	0	-	-	0	-	41	Econstitutive	0.08	-	-	0.01	-	-	-	-	-	-	0.00	-	-	0.00	-	0.03
GP174	GPR174		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	1	1	-	1	Gs	3	1'	3'	nc	2'	100	12	0	41	-	-	-	-	-	GsL	100	-	-	12	-	-	-	-	-	-	0	-	-	0	-	41	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GP182	GPR182		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
GP182	GPR182		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GP183	GPR183		A orphans	A	-	Bouvier	GEMTA	3	12		7α,25-dihydroxycholesterol	Phys	-	2	1	1	Gi/o	3	nc	1'	3'	2'	0	100	78	87	log(Emax/EC50)	0.0	9.1	7.1	7.9	GoB	0	-	-	98	99	-	-	91	93	100	0	0	0	78	87	0	log(Emax/EC50)	0.0	-	-	8.9	8.9	-	-	8.3	8.4	9.1	0.0	0.0	0.0	7.1	7.9	0.0
GP183	GPR183		A orphans	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	1	1	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GP183	GPR183		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	1	1	Gi/o	3	nc	1'	3'	2'	0	100	78	87	-	-	-	-	-	GoB	0	-	-	98	99	-	-	91	93	100	0	0	0	78	87	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MAS	MAS1		A orphans	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	1	-	Gq/11	2	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MAS	MAS1		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	1	-	Gq/11	2	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MRGRD	MRGPRD		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	2	2	1	Gi/o	3	nc	1'	2'	3'	0	100	50	45	Econstitutive	0.00	0.11	0.06	0.05	Gi1	0	-	-	100	-	-	-	-	-	-	37	-	-	50	-	45	Econstitutive	0.00	-	-	0.11	-	-	-	-	-	-	0.04	-	-	0.06	-	0.05
MRGRD	MRGPRD		A orphans	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	2	1	Gq/11	2	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MRGRD	MRGPRD		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	2	1	Gi/o	3	nc	1'	2'	3'	0	100	50	45	-	-	-	-	-	Gi1	0	-	-	100	-	-	-	-	-	-	37	-	-	50	-	45	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MRGRE	MRGPRE		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
MRGRE	MRGPRE		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MRGRF	MRGPRF		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
MRGRF	MRGPRF		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MRGRG	MRGPRG		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
MRGRG	MRGPRG		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MRGX1	MRGPRX1		A orphans	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	-	1	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MRGX1	MRGPRX1		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	1	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MRGX2	MRGPRX2		A orphans	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	1	-	Gq/11	2	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MRGX2	MRGPRX2		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	1	-	Gq/11	2	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MRGX3	MRGPRX3		A orphans	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	-	1	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MRGX3	MRGPRX3		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	1	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MRGX4	MRGPRX4		A orphans	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	-	1	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MRGX4	MRGPRX4		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	1	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
P2Y10	P2RY10		A orphans	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	2	-	2	Gi/o	2	nc	1'	nc	2'	0	100	0	97	Econstitutive	0.00	0.02	0.00	0.02	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	97	-	Econstitutive	0.00	-	-	0.02	-	-	-	-	-	-	0.00	-	-	-	0.02	-
P2Y10	P2RY10		A orphans	A	-	Lambert	RGB-GDP	0	6		18:1 Lyso PS	Phys	-	2	-	2	G12/13	2	nc	2'	nc	1'	0	98	0	100	Efficacy	0.00	0.03	0.00	0.03	G12	0	-	-	98	-	-	-	-	-	-	0	-	-	-	100	-	Efficacy	0.00	-	-	0.03	-	-	-	-	-	-	0.00	-	-	-	0.03	-
P2Y10	P2RY10		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	2	Gi/o	2	nc	1'	nc	2'	0	99	0	98	-	-	-	-	-	Gi1	0	-	-	99	-	-	-	-	-	-	0	-	-	-	98	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CALCR	CT		Calcitonin	B1	-	Bouvier	GEMTA	3	12		Human Calcitonin (hCT)	Phys	3	2	3	1	Gs	4	1'	4'	2'	3'	100	74	89	82	log(Emax/EC50)	11.7	8.7	10.4	9.6	GsL	100	-	-	68	68	-	-	63	68	74	68	62	67	89	72	82	log(Emax/EC50)	11.7	-	-	8.0	8.0	-	-	7.4	8.0	8.7	7.9	7.3	7.8	10.4	8.5	9.6
CALCR	CT		Calcitonin	B1	-	Martemyanov	FreeGβγ-Nluc	2	5		Human Calcitonin (hCT)	Phys	3	2	3	1	Gs	3	1'	3'	2'	4'	100	22	31	11	Activation rate (s^-1)	0.4	0.1	0.1	0.0	GsL	100	-	-	-	-	-	-	-	22	-	0	-	-	31	-	11	Activation rate (s^-1)	0.4	-	-	-	-	-	-	-	0.1	-	0.0	-	-	0.1	-	0.0
CALCR	CT		Calcitonin	B1	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	3	2	3	1	Gs	2	1'	-	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CALCR	CT		Calcitonin	B1	-	GproteinDb	merged data	-	-	-	-	-	3	2	3	1	Gs	4	1'	3'	2'	4'	100	48	60	46	-	-	-	-	-	GsL	100	-	-	68	68	-	-	63	45	74	34	62	67	60	72	46	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CALRL	Calcitonin -like		Calcitonin	B1	-	Martemyanov	FreeGβγ-Nluc	2	5		amylin	Phys	1	-	-	-	Gs	1	1'	nc	2'	nc	100	0	6	0	Activation rate (s^-1)	0.7	0.0	0.0	0.0	GsL	100	-	-	-	-	-	-	-	0	-	0	-	-	6	-	0	Activation rate (s^-1)	0.7	-	-	-	-	-	-	-	0.0	-	0.0	-	-	0.0	-	0.0
CALRL	Calcitonin -like		Calcitonin	B1	-	GproteinDb	merged data	-	-	-	-	-	1	-	-	-	Gs	2	1'	nc	2'	nc	100	0	6	0	-	-	-	-	-	GsL	100	-	-	-	-	-	-	-	0	-	0	-	-	6	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CRFR1	CRF₁		Corticotropin-releasing factor	B1	-	Bouvier	GEMTA	3	12		urocortin 2	Phys	3	2	3	2	G12/13	4	2'	3'	4'	1'	87	75	73	100	log(Emax/EC50)	7.4	6.4	6.2	8.5	G13	87	-	-	73	72	-	-	70	0	75	0	0	0	73	92	100	log(Emax/EC50)	7.4	-	-	6.2	6.2	-	-	5.9	0.0	6.4	0.0	0.0	0.0	6.2	7.8	8.5
CRFR1	CRF₁		Corticotropin-releasing factor	B1	-	Martemyanov	FreeGβγ-Nluc	2	5		Corticoliberin	Phys	3	2	3	2	Gs	4	1'	3'	2'	4'	100	9	9	2	Activation rate (s^-1)	4.1	0.4	0.4	0.1	GsL	100	-	-	-	-	-	-	-	9	-	0	-	-	9	-	2	Activation rate (s^-1)	4.1	-	-	-	-	-	-	-	0.4	-	0.0	-	-	0.4	-	0.1
CRFR1	CRF₁		Corticotropin-releasing factor	B1	-	GtoPdb	- (annotated from literature)	-	-		-	-	3	2	3	2	Gs	2	1'	-	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CRFR1	CRF₁		Corticotropin-releasing factor	B1	-	GproteinDb	merged data	-	-	-	-	-	3	2	3	2	Gs	4	1'	3'	4'	2'	94	42	41	51	-	-	-	-	-	GsL	94	-	-	73	72	-	-	70	4	75	0	0	0	41	92	51	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CRFR2	CRF₂		Corticotropin-releasing factor	B1	-	Bouvier	GEMTA	3	12		urocortin 2	Phys	3	2	3	-	Gs	3	1'	3'	2'	nc	100	77	84	0	log(Emax/EC50)	10.3	7.9	8.6	0.0	GsL	100	-	-	77	74	-	-	69	73	76	0	0	57	84	0	0	log(Emax/EC50)	10.3	-	-	7.9	7.6	-	-	7.1	7.6	7.8	0.0	0.0	5.8	8.6	0.0	0.0
CRFR2	CRF₂		Corticotropin-releasing factor	B1	-	Martemyanov	FreeGβγ-Nluc	2	5		Corticoliberin	Phys	3	2	3	-	Gs	3	1'	3'	2'	nc	100	13	14	0	Activation rate (s^-1)	1.7	0.2	0.2	0.0	GsL	100	-	-	-	-	-	-	-	13	-	0	-	-	14	-	0	Activation rate (s^-1)	1.7	-	-	-	-	-	-	-	0.2	-	0.0	-	-	0.2	-	0.0
CRFR2	CRF₂		Corticotropin-releasing factor	B1	-	GtoPdb	- (annotated from literature)	-	-		-	-	3	2	3	-	Gs	2	1'	-	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CRFR2	CRF₂		Corticotropin-releasing factor	B1	-	GproteinDb	merged data	-	-	-	-	-	3	2	3	-	Gs	3	1'	3'	2'	nc	100	45	49	0	-	-	-	-	-	GsL	100	-	-	77	74	-	-	69	43	76	0	0	57	49	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GHRHR	GHRH		Glucagon	B1	-	Martemyanov	FreeGβγ-Nluc	2	5		GHRH	Phys	1	-	-	-	Gs	0	1'	nc	nc	nc	100	0	0	0	Activation rate (s^-1)	0.0	0.0	0.0	0.0	GsL	100	-	-	-	-	-	-	-	0	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.0	-	0.0	-	-	0.0	-	0.0
GHRHR	GHRH		Glucagon	B1	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	-	-	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GHRHR	GHRH		Glucagon	B1	-	GproteinDb	merged data	-	-	-	-	-	1	-	-	-	Gs	1	1'	nc	nc	nc	100	0	0	0	-	-	-	-	-	GsL	100	-	-	-	-	-	-	-	0	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GIPR	GIP		Glucagon	B1	-	Bouvier	GEMTA	3	12		gastric inhibitory polypeptide	Phys	3	2	1	-	Gs	3	1'	3'	2'	nc	100	84	85	0	log(Emax/EC50)	10.4	8.7	8.8	0.0	GsL	100	-	-	79	81	-	-	81	79	84	0	0	62	85	0	0	log(Emax/EC50)	10.4	-	-	8.2	8.4	-	-	8.4	8.2	8.7	0.0	0.0	6.4	8.8	0.0	0.0
GIPR	GIP		Glucagon	B1	-	Martemyanov	FreeGβγ-Nluc	2	5		gastric inhibitory polypeptide	Phys	3	2	1	-	Gs	2	1'	2'	3'	nc	100	22	4	0	Activation rate (s^-1)	0.6	0.1	0.0	0.0	GsL	100	-	-	-	-	-	-	-	22	-	0	-	-	4	-	0	Activation rate (s^-1)	0.6	-	-	-	-	-	-	-	0.1	-	0.0	-	-	0.0	-	0.0
GIPR	GIP		Glucagon	B1	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	3	2	1	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GIPR	GIP		Glucagon	B1	-	GproteinDb	merged data	-	-	-	-	-	3	2	1	-	Gs	3	1'	2'	3'	nc	100	53	44	0	-	-	-	-	-	GsL	100	-	-	79	81	-	-	81	50	84	0	0	62	44	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GLP1R	GLP-1		Glucagon	B1	-	Bouvier	GEMTA	3	12		glucagon-like peptide 1-(7-37)	Phys	3	2	2	1	Gs	4	1'	2'	3'	4'	100	82	78	71	log(Emax/EC50)	10.6	8.7	8.2	7.6	GsL	100	-	-	67	64	-	-	82	71	77	0	0	0	78	0	71	log(Emax/EC50)	10.6	-	-	7.0	6.7	-	-	8.7	7.5	8.1	0.0	0.0	0.0	8.2	0.0	7.6
GLP1R	GLP-1		Glucagon	B1	-	Martemyanov	FreeGβγ-Nluc	2	5		CHEMBL410972	Phys	3	2	2	1	Gs	3	1'	2'	3'	nc	100	17	4	0	Activation rate (s^-1)	1.4	0.2	0.1	0.0	GsL	100	-	-	-	-	-	-	-	17	-	0	-	-	4	-	0	Activation rate (s^-1)	1.4	-	-	-	-	-	-	-	0.2	-	0.0	-	-	0.1	-	0.0
GLP1R	GLP-1		Glucagon	B1	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	3	2	2	1	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GLP1R	GLP-1		Glucagon	B1	-	GproteinDb	merged data	-	-	-	-	-	3	2	2	1	Gs	4	1'	2'	3'	4'	100	50	41	36	-	-	-	-	-	GsL	100	-	-	67	64	-	-	82	44	77	0	0	0	41	0	36	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GLP2R	GLP-2		Glucagon	B1	-	Bouvier	GEMTA	3	12		glucagon-like peptide 2	Phys	3	2	1	-	Gs	3	1'	2'	3'	nc	100	85	75	0	log(Emax/EC50)	10.1	8.5	7.6	0.0	GsL	100	-	-	77	73	-	-	77	84	85	0	0	0	75	0	0	log(Emax/EC50)	10.1	-	-	7.8	7.3	-	-	7.7	8.4	8.5	0.0	0.0	0.0	7.6	0.0	0.0
GLP2R	GLP-2		Glucagon	B1	-	Martemyanov	FreeGβγ-Nluc	2	5		glucagon-like peptide 2	Phys	3	2	1	-	Gs	2	1'	2'	3'	nc	100	86	4	0	Activation rate (s^-1)	0.6	0.5	0.0	0.0	GsL	100	-	-	-	-	-	-	-	86	-	0	-	-	4	-	0	Activation rate (s^-1)	0.6	-	-	-	-	-	-	-	0.5	-	0.0	-	-	0.0	-	0.0
GLP2R	GLP-2		Glucagon	B1	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	3	2	1	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GLP2R	GLP-2		Glucagon	B1	-	GproteinDb	merged data	-	-	-	-	-	3	2	1	-	Gs	3	1'	2'	3'	nc	100	86	40	0	-	-	-	-	-	GsL	100	-	-	77	73	-	-	77	85	85	0	0	0	40	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GLR	Glucagon		Glucagon	B1	-	Bouvier	GEMTA	3	12		glucagon	Phys	3	2	2	1	Gs	4	1'	3'	2'	4'	100	79	81	66	log(Emax/EC50)	11.0	8.6	8.9	7.2	GsL	100	-	-	73	70	-	-	72	75	79	57	56	56	81	0	66	log(Emax/EC50)	11.0	-	-	7.9	7.6	-	-	7.9	8.2	8.6	6.2	6.2	6.2	8.9	0.0	7.2
GLR	Glucagon		Glucagon	B1	-	Martemyanov	FreeGβγ-Nluc	2	5		glucagon	Phys	3	2	2	1	Gs	3	1'	2'	3'	nc	100	39	8	0	Activation rate (s^-1)	3.6	1.4	0.3	0.0	GsL	100	-	-	-	-	-	-	-	39	-	3	-	-	8	-	0	Activation rate (s^-1)	3.6	-	-	-	-	-	-	-	1.4	-	0.1	-	-	0.3	-	0.0
GLR	Glucagon		Glucagon	B1	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	3	2	2	1	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GLR	Glucagon		Glucagon	B1	-	GproteinDb	merged data	-	-	-	-	-	3	2	2	1	Gs	4	1'	2'	3'	4'	100	59	44	33	-	-	-	-	-	GsL	100	-	-	73	70	-	-	72	57	79	30	56	56	44	0	33	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SCTR	Secretin		Glucagon	B1	-	Martemyanov	FreeGβγ-Nluc	2	5		secretin	Phys	2	1	1	-	Gs	3	1'	2'	3'	nc	100	7	6	0	Activation rate (s^-1)	2.8	0.2	0.2	0.0	GsL	100	-	-	-	-	-	-	-	7	-	5	-	-	6	-	0	Activation rate (s^-1)	2.8	-	-	-	-	-	-	-	0.2	-	0.1	-	-	0.2	-	0.0
SCTR	Secretin		Glucagon	B1	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	2	1	1	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SCTR	Secretin		Glucagon	B1	-	GproteinDb	merged data	-	-	-	-	-	2	1	1	-	Gs	3	1'	2'	3'	nc	100	7	6	0	-	-	-	-	-	GsL	100	-	-	-	-	-	-	-	7	-	5	-	-	6	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PTH1R	PTH1		Parathyroid hormone	B1	-	Bouvier	GEMTA	3	12		teriparatide	Phys	3	2	4	2	Gs	4	1'	3'	2'	4'	100	71	82	68	log(Emax/EC50)	11.0	7.8	9.0	7.4	GsL	100	-	-	69	66	-	-	57	67	71	71	65	63	82	55	68	log(Emax/EC50)	11.0	-	-	7.6	7.2	-	-	6.3	7.4	7.8	7.8	7.1	7.0	9.0	6.0	7.4
PTH1R	PTH1		Parathyroid hormone	B1	-	Martemyanov	FreeGβγ-Nluc	2	5		teriparatide	Phys	3	2	4	2	Gs	4	1'	2'	3'	4'	100	23	11	3	Activation rate (s^-1)	2.1	0.5	0.2	0.1	GsL	100	-	-	-	-	-	-	-	23	-	5	-	-	11	-	3	Activation rate (s^-1)	2.1	-	-	-	-	-	-	-	0.5	-	0.1	-	-	0.2	-	0.1
PTH1R	PTH1		Parathyroid hormone	B1	-	Inoue	TGF𝛼	5	1		teriparatide	Phys	3	2	4	2	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.1	-	-	-	-	-
PTH1R	PTH1		Parathyroid hormone	B1	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	3	2	4	2	Gs	2	1'	-	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PTH1R	PTH1		Parathyroid hormone	B1	-	GproteinDb	merged data	-	-	-	-	-	3	2	4	2	Gs	4	1'	2'	3'	4'	100	47	46	36	-	-	-	-	-	GsL	100	-	-	69	66	-	-	57	45	71	38	65	63	46	55	36	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PTH2R	PTH2		Parathyroid hormone	B1	-	Martemyanov	FreeGβγ-Nluc	2	5		teriparatide	Phys	1	-	2	-	Gs	2	1'	nc	2'	nc	100	0	12	0	Activation rate (s^-1)	0.6	0.0	0.1	0.0	GsL	100	-	-	-	-	-	-	-	0	-	0	-	-	12	-	0	Activation rate (s^-1)	0.6	-	-	-	-	-	-	-	0.0	-	0.0	-	-	0.1	-	0.0
PTH2R	PTH2		Parathyroid hormone	B1	-	Inoue	TGF𝛼	5	1		TIP39	Phys	1	-	2	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.1	-	-	-	-	-
PTH2R	PTH2		Parathyroid hormone	B1	-	GproteinDb	merged data	-	-	-	-	-	1	-	2	-	Gs	2	1'	nc	2'	nc	100	0	12	0	-	-	-	-	-	GsL	100	-	-	-	-	-	-	-	0	-	0	-	-	12	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PACR	PAC₁		VIP and PACAP	B1	-	Martemyanov	FreeGβγ-Nluc	2	5		VIP	Phys	2	1	3	1	Gs	4	1'	4'	2'	3'	100	4	69	8	Activation rate (s^-1)	2.0	0.1	1.3	0.2	GsL	100	-	-	-	-	-	-	-	4	-	19	-	-	69	-	8	Activation rate (s^-1)	2.0	-	-	-	-	-	-	-	0.1	-	0.4	-	-	1.3	-	0.2
PACR	PAC₁		VIP and PACAP	B1	-	Inoue	TGF𝛼	5	1		PACAP-27	Phys	2	1	3	1	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.1	-	-	-	-	-
PACR	PAC₁		VIP and PACAP	B1	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	2	1	3	1	Gq/11	2	1'	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PACR	PAC₁		VIP and PACAP	B1	-	GproteinDb	merged data	-	-	-	-	-	2	1	3	1	Gs	4	1'	4'	2'	3'	100	4	69	8	-	-	-	-	-	GsL	100	-	-	-	-	-	-	-	4	-	19	-	-	69	-	8	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
VIPR1	VPAC₁		VIP and PACAP	B1	-	Bouvier	GEMTA	3	12		VIP	Phys	3	3	3	2	Gs	4	1'	4'	2'	3'	100	71	85	72	log(Emax/EC50)	11.2	8.0	9.5	8.1	GsL	100	-	-	67	68	-	-	64	64	71	71	65	58	85	66	72	log(Emax/EC50)	11.2	-	-	7.6	7.6	-	-	7.2	7.2	8.0	7.9	7.3	6.5	9.5	7.4	8.1
VIPR1	VPAC₁		VIP and PACAP	B1	-	Martemyanov	FreeGβγ-Nluc	2	5		VIP	Phys	3	3	3	2	Gs	4	1'	3'	2'	4'	100	5	11	2	Activation rate (s^-1)	4.0	0.2	0.4	0.1	GsL	100	-	-	-	-	-	-	-	5	-	2	-	-	11	-	2	Activation rate (s^-1)	4.0	-	-	-	-	-	-	-	0.2	-	0.1	-	-	0.4	-	0.1
VIPR1	VPAC₁		VIP and PACAP	B1	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	3	3	3	2	Gs	3	1'	2'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
VIPR1	VPAC₁		VIP and PACAP	B1	-	GproteinDb	merged data	-	-	-	-	-	3	3	3	2	Gs	4	1'	3'	2'	4'	100	38	48	37	-	-	-	-	-	GsL	100	-	-	67	68	-	-	64	34	71	36	65	58	48	66	37	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
VIPR2	VPAC₂		VIP and PACAP	B1	-	Martemyanov	FreeGβγ-Nluc	2	5		VIP	Phys	2	-	1	-	Gs	2	1'	nc	2'	nc	100	0	10	0	Activation rate (s^-1)	3.3	0.0	0.3	0.0	GsL	100	-	-	-	-	-	-	-	0	-	10	-	-	3	-	0	Activation rate (s^-1)	3.3	-	-	-	-	-	-	-	0.0	-	0.3	-	-	0.1	-	0.0
VIPR2	VPAC₂		VIP and PACAP	B1	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	2	-	1	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
VIPR2	VPAC₂		VIP and PACAP	B1	-	GproteinDb	merged data	-	-	-	-	-	2	-	1	-	Gs	2	1'	nc	2'	nc	100	0	10	0	-	-	-	-	-	GsL	100	-	-	-	-	-	-	-	0	-	10	-	-	3	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AGRL1	ADGRL1		ADGRL	B2	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	-	1	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AGRL1	ADGRL1		ADGRL	B2	-	GproteinDb	merged data	-	-	-	-	-	-	-	1	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AGRE2	ADGRE2		ADGRE	B2	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	-	1	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AGRE2	ADGRE2		ADGRE	B2	-	GproteinDb	merged data	-	-	-	-	-	-	-	1	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AGRE5	ADGRE5		ADGRE	B2	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	-	-	1	G12/13	1	-	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AGRE5	ADGRE5		ADGRE	B2	-	GproteinDb	merged data	-	-	-	-	-	-	-	-	1	G12/13	1	-	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AGRA2	ADGRA2		ADGRA	B2	-	Lambert	RGB-GDP	0	6	-	None (constitutive activity)	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	Efficacy	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	0	0	Efficacy	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	0.00	0.00
AGRA2	ADGRA2		ADGRA	B2	-	GproteinDb	merged data	-	-	-	-	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AGRA3	ADGRA3		ADGRA	B2	-	Lambert	RGB-GDP	0	6	-	None (constitutive activity)	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	Efficacy	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	0	0	Efficacy	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	0.00	0.00
AGRA3	ADGRA3		ADGRA	B2	-	GproteinDb	merged data	-	-	-	-	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AGRD1	ADGRD1		ADGRD	B2	-	Lambert	RGB-GDP	0	6	-	None (constitutive activity)	-	1	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	Efficacy	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	0	0	Efficacy	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	0.00	0.00
AGRD1	ADGRD1		ADGRD	B2	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	-	-	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AGRD1	ADGRD1		ADGRD	B2	-	GproteinDb	merged data	-	-	-	-	-	1	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AGRD2	ADGRD2		ADGRD	B2	-	Lambert	RGB-GDP	0	6	-	None (constitutive activity)	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	Efficacy	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	0	0	Efficacy	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	0.00	0.00
AGRD2	ADGRD2		ADGRD	B2	-	GproteinDb	merged data	-	-	-	-	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AGRF1	ADGRF1		ADGRF	B2	-	Lambert	RGB-GDP	0	6	-	None (constitutive activity)	-	-	1	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Efficacy	0.00	0.01	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	0	0	0	Efficacy	0.00	-	-	0.01	-	-	-	-	-	-	0.00	-	-	0.00	0.00	0.00
AGRF1	ADGRF1		ADGRF	B2	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AGRF2	ADGRF2		ADGRF	B2	-	Lambert	RGB-GDP	0	6	-	None (constitutive activity)	-	-	1	1	1	Gi/o	3	nc	1'	2'	3'	0	100	95	64	Efficacy	0.00	0.04	0.04	0.02	Gi1	0	-	-	100	-	-	-	-	-	-	92	-	-	95	48	64	Efficacy	0.00	-	-	0.04	-	-	-	-	-	-	0.04	-	-	0.04	0.02	0.02
AGRF2	ADGRF2		ADGRF	B2	-	GproteinDb	merged data	-	-	-	-	-	-	1	1	1	Gi/o	3	nc	1'	2'	3'	0	100	95	64	-	-	-	-	-	Gi1	0	-	-	100	-	-	-	-	-	-	92	-	-	95	48	64	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AGRF3	ADGRF3		ADGRF	B2	-	Lambert	RGB-GDP	0	6	-	None (constitutive activity)	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	Efficacy	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	0	0	Efficacy	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	0.00	0.00
AGRF3	ADGRF3		ADGRF	B2	-	GproteinDb	merged data	-	-	-	-	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AGRF4	ADGRF4		ADGRF	B2	-	Lambert	RGB-GDP	0	6	-	None (constitutive activity)	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	Efficacy	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	0	0	Efficacy	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	0.00	0.00
AGRF4	ADGRF4		ADGRF	B2	-	GproteinDb	merged data	-	-	-	-	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AGRF5	ADGRF5		ADGRF	B2	-	Lambert	RGB-GDP	0	6	-	None (constitutive activity)	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	Efficacy	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	0	0	Efficacy	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	0.00	0.00
AGRF5	ADGRF5		ADGRF	B2	-	GproteinDb	merged data	-	-	-	-	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AGRG1	ADGRG1		ADGRG	B2	-	Lambert	RGB-GDP	0	6	-	None (constitutive activity)	-	-	-	1	2	G12/13	1	nc	nc	nc	1'	0	0	0	100	Efficacy	0.00	0.00	0.00	0.01	G12	0	-	-	0	-	-	-	-	-	-	0	-	-	0	100	0	Efficacy	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	0.01	0.00
AGRG1	ADGRG1		ADGRG	B2	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	-	1	2	Gq/11	2	-	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AGRG1	ADGRG1		ADGRG	B2	-	GproteinDb	merged data	-	-	-	-	-	-	-	1	2	G12/13	1	nc	nc	nc	1'	0	0	0	100	-	-	-	-	-	G12	0	-	-	0	-	-	-	-	-	-	0	-	-	0	100	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AGRG2	ADGRG2		ADGRG	B2	-	Lambert	RGB-GDP	0	6	-	None (constitutive activity)	-	-	-	1	-	-	0	nc	nc	nc	nc	0	0	0	0	Efficacy	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	0	0	Efficacy	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	0.00	0.00
AGRG2	ADGRG2		ADGRG	B2	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	-	1	-	-	1	-	-	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AGRG2	ADGRG2		ADGRG	B2	-	GproteinDb	merged data	-	-	-	-	-	-	-	1	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AGRG3	ADGRG3		ADGRG	B2	-	Lambert	RGB-GDP	0	6	-	None (constitutive activity)	-	-	1	-	1	G12/13	1	nc	nc	nc	1'	0	0	0	100	Efficacy	0.00	0.00	0.00	0.03	G13	0	-	-	0	-	-	-	-	-	-	0	-	-	0	52	100	Efficacy	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	0.01	0.03
AGRG3	ADGRG3		ADGRG	B2	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	-	1	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AGRG3	ADGRG3		ADGRG	B2	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	1	G12/13	1	nc	nc	nc	1'	0	0	0	100	-	-	-	-	-	G13	0	-	-	0	-	-	-	-	-	-	0	-	-	0	52	100	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AGRG5	ADGRG5		ADGRG	B2	-	Lambert	RGB-GDP	0	6	-	None (constitutive activity)	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	Efficacy	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	0	0	Efficacy	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	0.00	0.00
AGRG5	ADGRG5		ADGRG	B2	-	GproteinDb	merged data	-	-	-	-	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AGRG6	ADGRG6		ADGRG	B2	-	Lambert	RGB-GDP	0	6	-	None (constitutive activity)	-	1	-	-	-	Gs	1	1'	nc	nc	nc	100	0	0	0	Efficacy	0.01	0.00	0.00	0.00	GsL	100	-	-	0	-	-	-	-	-	-	0	-	-	0	0	0	Efficacy	0.01	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	0.00	0.00
AGRG6	ADGRG6		ADGRG	B2	-	GproteinDb	merged data	-	-	-	-	-	1	-	-	-	Gs	1	1'	nc	nc	nc	100	0	0	0	-	-	-	-	-	GsL	100	-	-	0	-	-	-	-	-	-	0	-	-	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CASR	CaS		Calcium-sensing	C	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	1	1	Gi/o	3	-	1'	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CASR	CaS		Calcium-sensing	C	-	GproteinDb	merged data	-	-	-	-	-	-	1	1	1	Gi/o	3	-	1'	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GRM1	mGlu₁		Metabotropic glutamate	C	-	Martemyanov	FreeGβγ-Nluc	2	5		L-glutamic acid	Phys	1	2	2	-	Gq/11	2	nc	2'	1'	nc	0	85	100	0	Activation rate (s^-1)	0.0	0.6	0.7	0.0	Gq	0	-	-	-	-	-	-	-	85	-	100	-	-	7	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.6	-	0.7	-	-	0.0	-	0.0
GRM1	mGlu₁		Metabotropic glutamate	C	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	2	2	-	Gq/11	3	2'	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GRM1	mGlu₁		Metabotropic glutamate	C	-	GproteinDb	merged data	-	-	-	-	-	1	2	2	-	Gq/11	2	nc	2'	1'	nc	0	85	100	0	-	-	-	-	-	Gq	0	-	-	-	-	-	-	-	85	-	100	-	-	7	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GRM2	mGlu₂		Metabotropic glutamate	C	-	Bouvier	GEMTA	3	12		L-glutamic acid	Phys	-	3	1	-	Gi/o	2	nc	1'	2'	nc	0	100	94	0	log(Emax/EC50)	0.0	5.1	4.8	0.0	Gi1	0	-	-	100	91	-	-	84	98	99	0	0	0	94	0	0	log(Emax/EC50)	0.0	-	-	5.1	4.6	-	-	4.3	5.0	5.0	0.0	0.0	0.0	4.8	0.0	0.0
GRM2	mGlu₂		Metabotropic glutamate	C	-	Martemyanov	FreeGβγ-Nluc	2	5		L-glutamic acid	Phys	-	3	1	-	Gi/o	1	nc	1'	2'	nc	0	100	1	0	Activation rate (s^-1)	0.0	5.9	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	1	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	5.9	-	0.0	-	-	0.0	-	0.0
GRM2	mGlu₂		Metabotropic glutamate	C	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	3	1	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GRM2	mGlu₂		Metabotropic glutamate	C	-	GproteinDb	merged data	-	-	-	-	-	-	3	1	-	Gi/o	2	nc	1'	2'	nc	0	100	48	0	-	-	-	-	-	Gi1	0	-	-	100	91	-	-	84	99	99	0	0	0	48	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GRM3	mGlu₃		Metabotropic glutamate	C	-	Martemyanov	FreeGβγ-Nluc	2	5		L-glutamic acid	Phys	-	2	-	-	Gi/o	1	nc	1'	2'	nc	0	100	2	0	Activation rate (s^-1)	0.0	0.6	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	2	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.6	-	0.0	-	-	0.0	-	0.0
GRM3	mGlu₃		Metabotropic glutamate	C	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GRM3	mGlu₃		Metabotropic glutamate	C	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	-	Gi/o	2	nc	1'	2'	nc	0	100	2	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	2	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GRM4	mGlu₄		Metabotropic glutamate	C	-	Bouvier	GEMTA	3	12		L-glutamic acid	Phys	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	log(Emax/EC50)	0.0	4.1	0.0	0.0	GoA	0	-	-	87	0	-	-	0	100	98	0	0	0	0	0	0	log(Emax/EC50)	0.0	-	-	3.6	0.0	-	-	0.0	4.1	4.0	0.0	0.0	0.0	0.0	0.0	0.0
GRM4	mGlu₄		Metabotropic glutamate	C	-	Martemyanov	FreeGβγ-Nluc	2	5		L-glutamic acid	Phys	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	0.7	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.7	-	0.0	-	-	0.0	-	0.0
GRM4	mGlu₄		Metabotropic glutamate	C	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	3	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GRM4	mGlu₄		Metabotropic glutamate	C	-	GproteinDb	merged data	-	-	-	-	-	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	GoA	0	-	-	87	0	-	-	0	100	98	0	0	0	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GRM5	mGlu₅		Metabotropic glutamate	C	-	Bouvier	GEMTA	3	12		L-glutamic acid	Phys	1	3	3	-	Gq/11	2	nc	2'	1'	nc	0	91	100	0	log(Emax/EC50)	0.0	5.3	5.8	0.0	G15	0	-	-	91	86	-	-	81	86	84	95	96	84	100	0	0	log(Emax/EC50)	0.0	-	-	5.3	5.0	-	-	4.7	5.0	4.9	5.5	5.6	4.9	5.8	0.0	0.0
GRM5	mGlu₅		Metabotropic glutamate	C	-	Martemyanov	FreeGβγ-Nluc	2	5		L-glutamic acid	Phys	1	3	3	-	Gi/o	2	nc	1'	2'	nc	0	100	41	0	Activation rate (s^-1)	0.0	0.8	0.3	0.0	GoA	0	-	-	-	-	-	-	-	100	-	41	-	-	9	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.8	-	0.3	-	-	0.1	-	0.0
GRM5	mGlu₅		Metabotropic glutamate	C	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	3	3	-	Gq/11	3	2'	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GRM5	mGlu₅		Metabotropic glutamate	C	-	GproteinDb	merged data	-	-	-	-	-	1	3	3	-	Gi/o	2	nc	1'	2'	nc	0	96	70	0	-	-	-	-	-	G11	0	-	-	91	86	-	-	81	93	84	68	96	84	54	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GRM6	mGlu₆		Metabotropic glutamate	C	-	Bouvier	GEMTA	3	12		L-glutamic acid	Phys	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	log(Emax/EC50)	0.0	4.5	0.0	0.0	GoB	0	-	-	94	86	-	-	81	96	100	0	0	0	0	0	0	log(Emax/EC50)	0.0	-	-	4.2	3.8	-	-	3.6	4.3	4.5	0.0	0.0	0.0	0.0	0.0	0.0
GRM6	mGlu₆		Metabotropic glutamate	C	-	Martemyanov	FreeGβγ-Nluc	2	5		L-glutamic acid	Phys	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	2.5	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	2.5	-	0.0	-	-	0.0	-	0.0
GRM6	mGlu₆		Metabotropic glutamate	C	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	3	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GRM6	mGlu₆		Metabotropic glutamate	C	-	GproteinDb	merged data	-	-	-	-	-	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	GoB	0	-	-	94	86	-	-	81	98	100	0	0	0	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GRM7	mGlu₇		Metabotropic glutamate	C	-	Martemyanov	FreeGβγ-Nluc	2	5		L-glutamic acid	Phys	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	0.2	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.2	-	0.0	-	-	0.0	-	0.0
GRM7	mGlu₇		Metabotropic glutamate	C	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GRM7	mGlu₇		Metabotropic glutamate	C	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GRM8	mGlu₈		Metabotropic glutamate	C	-	Bouvier	GEMTA	3	12		L-glutamic acid	Phys	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	log(Emax/EC50)	0.0	5.3	0.0	0.0	Gi1	0	-	-	100	92	-	-	88	94	94	0	0	0	0	0	0	log(Emax/EC50)	0.0	-	-	5.3	4.8	-	-	4.6	5.0	5.0	0.0	0.0	0.0	0.0	0.0	0.0
GRM8	mGlu₈		Metabotropic glutamate	C	-	Martemyanov	FreeGβγ-Nluc	2	5		L-glutamic acid	Phys	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	0.3	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.3	-	0.0	-	-	0.0	-	0.0
GRM8	mGlu₈		Metabotropic glutamate	C	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	3	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GRM8	mGlu₈		Metabotropic glutamate	C	-	GproteinDb	merged data	-	-	-	-	-	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	Gi1	0	-	-	100	92	-	-	88	97	94	0	0	0	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FZD2	FZD₂		Frizzled	F	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FZD2	FZD₂		Frizzled	F	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPC6A	GPRC6		C Orphans	C	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	-	1	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPC6A	GPRC6		C Orphans	C	-	GproteinDb	merged data	-	-	-	-	-	-	-	1	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
STE2	STE2		STE2	D1	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	-	-	-	GPa1 family	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
STE2	STE2		STE2	D1	-	GproteinDb	merged data	-	-	-	-	-	-	-	-	-	GPa1 family	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FZD1	FZD₁		Frizzled	F	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	1	-	-	2	-	2'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FZD1	FZD₁		Frizzled	F	-	GproteinDb	merged data	-	-	-	-	-	-	1	1	-	-	2	-	2'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FZD3	FZD₃		Frizzled	F	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	-	-	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FZD3	FZD₃		Frizzled	F	-	GproteinDb	merged data	-	-	-	-	-	1	-	-	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FZD4	FZD₄		Frizzled	F	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	-	-	1	G12/13	1	-	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FZD4	FZD₄		Frizzled	F	-	GproteinDb	merged data	-	-	-	-	-	-	-	-	1	G12/13	1	-	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FZD6	FZD₆		Frizzled	F	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	1	-	Gi/o	2	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FZD6	FZD₆		Frizzled	F	-	GproteinDb	merged data	-	-	-	-	-	-	1	1	-	Gi/o	2	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FZD7	FZD₇		Frizzled	F	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	1	-	-	Gs	2	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FZD7	FZD₇		Frizzled	F	-	GproteinDb	merged data	-	-	-	-	-	1	1	-	-	Gs	2	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FZD9	FZD₉		Frizzled	F	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FZD9	FZD₉		Frizzled	F	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FZD10	FZD₁₀		Frizzled	F	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	-	-	1	-	1	-	-	-	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FZD10	FZD₁₀		Frizzled	F	-	GproteinDb	merged data	-	-	-	-	-	-	-	-	1	-	1	-	-	-	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SMO	SMO		Frizzled	F	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	1	Gi/o	2	-	1'	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SMO	SMO		Frizzled	F	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	1	Gi/o	2	-	1'	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GP157	GPR157		Other GPCR orphans	O	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
GP157	GPR157		Other GPCR orphans	O	-	GproteinDb	merged data	-	-	-	-	-	-	-	-	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CALCR	CT		Calcitonin	B1	RAMP3	Bouvier	GEMTA	3	12		amylin	Phys	1	-	1	1	G12/13	3	2'	nc	3'	1'	90	0	78	100	log(Emax/EC50)	7.3	0.0	6.3	8.1	G13	90	-	-	0	0	-	-	0	0	0	0	0	0	78	93	100	log(Emax/EC50)	7.3	-	-	0.0	0.0	-	-	0.0	0.0	0.0	0.0	0.0	0.0	6.3	7.5	8.1
CALCR	CT		Calcitonin	B1	RAMP3	GproteinDb	merged data	-	-	-	-	-	1	-	1	1	G12/13	3	2'	nc	3'	1'	90	0	78	100	-	-	-	-	-	G13	90	-	-	0	0	-	-	0	0	0	0	0	0	78	93	100	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-

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