Structure information

ORF74

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8K4O

SPECIES

Human herpesvirus 8

RESOLUTION

3.010

PREFERRED CHAIN

E

REFERENCE

PUBLICATION DATE

July 24, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Growth-regulated alpha protein F6 N-term hydrophobic
Growth-regulated alpha protein L7 N-term Van der Waals
Growth-regulated alpha protein L7 N-term polar (hydrogen bond with backbone)
Growth-regulated alpha protein T8 N-term Van der Waals
Growth-regulated alpha protein T8 N-term polar (hydrogen bond)
Growth-regulated alpha protein L11 N-term Van der Waals
Growth-regulated alpha protein L11 N-term hydrophobic
Growth-regulated alpha protein D13 N-term polar (charge-assisted hydrogen bond)
Growth-regulated alpha protein W17 N-term hydrophobic
Growth-regulated alpha protein W17 N-term Van der Waals
Growth-regulated alpha protein E19 N-term Van der Waals
Growth-regulated alpha protein L21 N-term Van der Waals
Growth-regulated alpha protein L21 N-term hydrophobic
Growth-regulated alpha protein Y26 N-term Van der Waals
Growth-regulated alpha protein Y26 N-term polar (hydrogen bond)
Growth-regulated alpha protein D27 N-term Van der Waals
Growth-regulated alpha protein D27 N-term polar (hydrogen bond with backbone)
Growth-regulated alpha protein Y28 N-term Van der Waals
Growth-regulated alpha protein Y28 N-term aromatic (face-to-edge)
Growth-regulated alpha protein F32 N-term Van der Waals
Growth-regulated alpha protein F32 N-term hydrophobic
Growth-regulated alpha protein S33 N-term Van der Waals
Growth-regulated alpha protein L34 N-term Van der Waals
Growth-regulated alpha protein L34 N-term polar (hydrogen bond with backbone)
Growth-regulated alpha protein S37 N-term polar (hydrogen bond with backbone)
Growth-regulated alpha protein S37 N-term polar (hydrogen bond)
Growth-regulated alpha protein S37 N-term Van der Waals
Growth-regulated alpha protein V38 N-term hydrophobic
Growth-regulated alpha protein V38 N-term Van der Waals
Growth-regulated alpha protein C39 N-term polar (hydrogen bond with backbone)
Growth-regulated alpha protein C39 N-term Van der Waals
Growth-regulated alpha protein E40 N-term Van der Waals
Growth-regulated alpha protein E103 2.60x60 TM2 Van der Waals
Growth-regulated alpha protein E121 3.28x28 TM3 Van der Waals
Growth-regulated alpha protein Y125 3.32x32 TM3 Van der Waals
Growth-regulated alpha protein Y125 3.32x32 TM3 hydrophobic
Growth-regulated alpha protein R183 ECL2 polar (charge-assisted hydrogen bond)
Growth-regulated alpha protein P189 ECL2 hydrophobic
Growth-regulated alpha protein P189 ECL2 Van der Waals
Growth-regulated alpha protein Y197 45.51x51 ECL2 Van der Waals
Growth-regulated alpha protein Y197 45.51x51 ECL2 hydrophobic
Growth-regulated alpha protein T204 5.31x31 TM5 Van der Waals
Growth-regulated alpha protein R208 5.35x35 TM5 Van der Waals
Growth-regulated alpha protein D274 6.58x58 TM6 polar (charge-assisted hydrogen bond)
Growth-regulated alpha protein R278 6.62x62 TM6 polar (charge-assisted hydrogen bond)
Growth-regulated alpha protein D284 ECL3 Van der Waals
Growth-regulated alpha protein S285 7.24x23 TM7 Van der Waals
Growth-regulated alpha protein R289 7.28x27 TM7 polar (charge-assisted hydrogen bond)
Growth-regulated alpha protein N293 7.32x31 TM7 polar (hydrogen bond)
Growth-regulated alpha protein N293 7.32x31 TM7 Van der Waals
Growth-regulated alpha protein L296 7.35x34 TM7 hydrophobic
Growth-regulated alpha protein L296 7.35x34 TM7 Van der Waals
Growth-regulated alpha protein A297 7.36x35 TM7 Van der Waals

Ligands

Growth-regulated alpha protein

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Residue Diagrams

G N G L V N I L F I L S L I G V N W T Y 1 L G I C L N S L C L S I S L L A E V L M 2 C V V S F I D L Y V Y L Y Y F F I E L R 3 G W V L T S A A L L I A L V L S G D A C 4 Y F L I L L A L P L L F G A T V S V T R 5 V A V V L L F F V F C F P Y H V L N L L 6 L P V V A S Y L A Q L L S T V A L G V 7
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ECL1 P N I I ECL1ICL2 S T R S W P K ICL2ECL2 H R S R V V D P V S K Q A M C Y E N ECL2ICL3 K L Q ICL3ECL3 R W I R D ECL3N-term M A A E D F L T I F L D D D E S W N E T L N M S G Y D Y S G N F S L E V S V C E M T T V V N-termC-term T T C-term P Y T W N V G I L S L I F L I N V L G N G L V T Y I F C K H R S R A G A I D I L L L G I C L N S L C L S I S L L A E V L M F L F S T G L C R L E I F F Y Y L Y V Y L D I F S V V C V S L V R Y L L V A Y K Q S L G W V L T S A A L L I A L V L S G D A C R A G N M T A D W R L H V R T V S V T A G F L L P L A L L I L F Y A L T W C V V R R T A R R K V R G V I V A V V L L F F V F C F P Y H V L N L L D T L L R R S C Y T R G L I N V G L A V T S L L Q A L Y S A V V P L I Y S C L G S L F Y G L R Q S A R Q R M F Q S L F M S G
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Residue Table


GPCRdb(A)
GPCRdb(A)
ORF74
TM2
2x60 2.60x60 E103
TM3
3x28 3.28x28 E121
3x32 3.32x32 Y125
ECL2
45x51 45.51x51 Y197
TM5
5x31 5.31x31 T204
5x35 5.35x35 R208
TM6
6x58 6.58x58 D274
6x62 6.62x62 R278
TM7
7x23 7.24x23 S285
7x27 7.28x27 R289
7x31 7.32x31 N293
7x34 7.35x34 L296
7x35 7.36x35 A297