ArrestinDb

Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	AssayType	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	CHEMBL5093342	215564	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5095971	215564	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	11329254	85216	0	None	-	1	Guinea pig	5.0	pEC50	=	5	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	450	9	1	5	4.5	O=C(CCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1)NC1CCCc2ccccc21	10.1021/jm070487n
	CHEMBL225571	85216	0	None	-	1	Guinea pig	5.0	pEC50	=	5	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	450	9	1	5	4.5	O=C(CCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1)NC1CCCc2ccccc21	10.1021/jm070487n
	CHEMBL5093342	215564	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5095971	215564	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	5	139	72	None	-9	26	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	5202	139	72	None	-9	26	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	CHEMBL39	139	72	None	-9	26	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	DB08839	139	72	None	-9	26	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	134138168	147691	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL3931889	147691	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	5	139	72	None	-9	26	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	5202	139	72	None	-9	26	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	CHEMBL39	139	72	None	-9	26	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	DB08839	139	72	None	-9	26	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	135367816	164835	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218801	164835	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	135367816	164835	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218801	164835	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	134138168	147691	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL3931889	147691	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	23643870	92864	0	None	-	1	Guinea pig	5.9	pEC50	=	5.9	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	448	9	1	4	4.6	CN(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL243955	92864	0	None	-	1	Guinea pig	5.9	pEC50	=	5.9	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	448	9	1	4	4.6	CN(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL5081379	214746	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5081379	214746	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	135367820	164821	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218672	164821	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	135367820	164821	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218672	164821	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL5094493	215499	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCCN(CCC)CCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5094493	215499	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCCN(CCC)CCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	92042876	151336	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL3961059	151336	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	5	139	72	None	-9	26	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assayAgonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8014553
	5202	139	72	None	-9	26	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assayAgonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8014553
	CHEMBL39	139	72	None	-9	26	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assayAgonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8014553
	DB08839	139	72	None	-9	26	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assayAgonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8014553
	92042876	151336	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL3961059	151336	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	67268994	163968	2	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4207884	163968	2	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	67268994	163968	2	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4207884	163968	2	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	135367405	164196	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4210782	164196	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	135367405	164196	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4210782	164196	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	5	139	72	None	-9	26	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm500880c
	5202	139	72	None	-9	26	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm500880c
	CHEMBL39	139	72	None	-9	26	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm500880c
	DB08839	139	72	None	-9	26	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm500880c
	11385992	84668	0	None	-	1	Guinea pig	4.8	pEC50	=	4.8	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	439	8	1	3	5.2	O=C(CCCCCN1CCN(c2ccccc2Cl)CC1)NC1CCCc2ccccc21	10.1021/jm070487n
	CHEMBL222477	84668	0	None	-	1	Guinea pig	4.8	pEC50	=	4.8	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	439	8	1	3	5.2	O=C(CCCCCN1CCN(c2ccccc2Cl)CC1)NC1CCCc2ccccc21	10.1021/jm070487n
	23643664	2350	8	None	-	1	Guinea pig	5.8	pEC50	=	5.8	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm070487n
	8434	2350	8	None	-	1	Guinea pig	5.8	pEC50	=	5.8	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm070487n
	CHEMBL243954	2350	8	None	-	1	Guinea pig	5.8	pEC50	=	5.8	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm070487n
	CHEMBL5094234	215573	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5096019	215573	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5094234	215573	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5096019	215573	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	11785183	84713	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	419	8	1	3	4.9	Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL222755	84713	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	419	8	1	3	4.9	Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	124247485	164069	8	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4209274	164069	8	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL5084249	214905	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCN(CC)CCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	124247485	164069	8	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4209274	164069	8	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL5084249	214905	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCN(CC)CCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	24825775	1523	14	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	3929	1523	14	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	CHEMBL4205349	1523	14	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	24825775	1523	14	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	3929	1523	14	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	CHEMBL4205349	1523	14	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	102364516	113543	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay	ChEMBL	346	6	0	2	4.0	O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1	10.1021/jm500880c
	CHEMBL3321794	113543	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay	ChEMBL	346	6	0	2	4.0	O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1	10.1021/jm500880c
	11282296	143315	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	447	9	1	4	4.8	CC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL389718	143315	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	447	9	1	4	4.8	CC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	11224758	2353	5	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/jm049702f
	8435	2353	5	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/jm049702f
	CHEMBL225284	2353	5	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/jm049702f
	5	139	72	None	-9	26	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assayAgonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2021.113243
	5202	139	72	None	-9	26	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assayAgonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2021.113243
	CHEMBL39	139	72	None	-9	26	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assayAgonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2021.113243
	DB08839	139	72	None	-9	26	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assayAgonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2021.113243
	25107520	187593	0	None	-	1	Guinea pig	6.5	pEC50	=	6.5	Functional	Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	442	10	1	4	4.7	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1	10.1021/jm800615e
	CHEMBL494709	187593	0	None	-	1	Guinea pig	6.5	pEC50	=	6.5	Functional	Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	442	10	1	4	4.7	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1	10.1021/jm800615e
	42625440	170813	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assayAgonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assay	ChEMBL	320	5	0	2	3.4	O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1	10.1021/jm8014553
	CHEMBL445334	170813	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assayAgonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assay	ChEMBL	320	5	0	2	3.4	O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1	10.1021/jm8014553
	92042877	149175	1	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	241	4	1	2	3.4	CNCc1ccc(C)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	CHEMBL3943658	149175	1	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	241	4	1	2	3.4	CNCc1ccc(C)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	92042877	149175	1	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	241	4	1	2	3.4	CNCc1ccc(C)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	CHEMBL3943658	149175	1	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	241	4	1	2	3.4	CNCc1ccc(C)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	5	139	72	None	-9	26	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	5202	139	72	None	-9	26	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	CHEMBL39	139	72	None	-9	26	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	DB08839	139	72	None	-9	26	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	135367857	164604	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4215875	164604	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	135367857	164604	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4215875	164604	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	92042876	151336	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL3961059	151336	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	92042876	151336	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL3961059	151336	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	5	139	72	None	-9	26	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b00642
	5202	139	72	None	-9	26	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b00642
	CHEMBL39	139	72	None	-9	26	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b00642
	DB08839	139	72	None	-9	26	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b00642
	134138168	147691	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL3931889	147691	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	5	139	72	None	-9	26	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b00642
	5202	139	72	None	-9	26	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b00642
	CHEMBL39	139	72	None	-9	26	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b00642
	DB08839	139	72	None	-9	26	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b00642
	134138168	147691	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL3931889	147691	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	25107648	187223	0	None	-	1	Guinea pig	6.3	pEC50	=	6.3	Functional	Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	467	8	0	3	5.6	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCc2ccccc2C1	10.1021/jm800615e
	CHEMBL492480	187223	0	None	-	1	Guinea pig	6.3	pEC50	=	6.3	Functional	Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	467	8	0	3	5.6	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCc2ccccc2C1	10.1021/jm800615e
	1809	134	32	None	-194	8	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT7 receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assayAgonist activity at human 5HT7 receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assay	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.ejmech.2020.112709
	4	134	32	None	-194	8	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT7 receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assayAgonist activity at human 5HT7 receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assay	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.ejmech.2020.112709
	CHEMBL18840	134	32	None	-194	8	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT7 receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assayAgonist activity at human 5HT7 receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assay	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.ejmech.2020.112709
	5	139	72	None	-9	26	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
	5202	139	72	None	-9	26	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
	CHEMBL39	139	72	None	-9	26	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
	DB08839	139	72	None	-9	26	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
	5	139	72	None	-9	26	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
	5202	139	72	None	-9	26	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
	CHEMBL39	139	72	None	-9	26	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
	DB08839	139	72	None	-9	26	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
	92042876	151336	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	CHEMBL3961059	151336	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	92042876	151336	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	CHEMBL3961059	151336	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	CHEMBL5074190	214314	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL		None	None	None		COc1ccccc1-c1cc(CCN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL5074190	214314	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL		None	None	None		COc1ccccc1-c1cc(CCN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL5083607	214873	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	135453290	133606	33	None	-2818	7	Human	5.3	pEC50	=	5.3	Functional	Activity at 5HT7 receptor expressed in human corneal epithelial CEPI-17-CL4 cells by adenylyl cyclase assayActivity at 5HT7 receptor expressed in human corneal epithelial CEPI-17-CL4 cells by adenylyl cyclase assay	ChEMBL	191	2	2	4	1.1	C[C@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	CHEMBL371300	133606	33	None	-2818	7	Human	5.3	pEC50	=	5.3	Functional	Activity at 5HT7 receptor expressed in human corneal epithelial CEPI-17-CL4 cells by adenylyl cyclase assayActivity at 5HT7 receptor expressed in human corneal epithelial CEPI-17-CL4 cells by adenylyl cyclase assay	ChEMBL	191	2	2	4	1.1	C[C@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	CHEMBL5083607	214873	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	118709756	113547	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay	ChEMBL	352	6	0	2	4.4	O=C1Cc2ccccc2N1CC/C=C/CCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
	CHEMBL3321798	113547	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay	ChEMBL	352	6	0	2	4.4	O=C1Cc2ccccc2N1CC/C=C/CCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
	25107716	2351	43	None	-	1	Guinea pig	6.2	pEC50	=	6.2	Functional	Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm800615e
	8436	2351	43	None	-	1	Guinea pig	6.2	pEC50	=	6.2	Functional	Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm800615e
	CHEMBL522691	2351	43	None	-	1	Guinea pig	6.2	pEC50	=	6.2	Functional	Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm800615e
	1809	134	32	None	-194	8	Human	6.2	pEC50	=	6.2	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm049702f
	4	134	32	None	-194	8	Human	6.2	pEC50	=	6.2	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm049702f
	CHEMBL18840	134	32	None	-194	8	Human	6.2	pEC50	=	6.2	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm049702f
	1809	134	32	None	-2137	8	Guinea pig	6.2	pEC50	=	6.2	Functional	Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm800615e
	4	134	32	None	-2137	8	Guinea pig	6.2	pEC50	=	6.2	Functional	Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm800615e
	CHEMBL18840	134	32	None	-2137	8	Guinea pig	6.2	pEC50	=	6.2	Functional	Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm800615e
	1809	134	32	None	-2137	8	Guinea pig	6.2	pEC50	=	6.2	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm070487n
	4	134	32	None	-2137	8	Guinea pig	6.2	pEC50	=	6.2	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm070487n
	CHEMBL18840	134	32	None	-2137	8	Guinea pig	6.2	pEC50	=	6.2	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm070487n
	11432177	85122	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	435	9	1	4	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL224820	85122	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	435	9	1	4	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL5083607	214873	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL5083607	214873	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	5	139	72	None	-9	26	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assayAgonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2018.04.059
	5202	139	72	None	-9	26	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assayAgonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2018.04.059
	CHEMBL39	139	72	None	-9	26	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assayAgonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2018.04.059
	DB08839	139	72	None	-9	26	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assayAgonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2018.04.059
	5	139	72	None	-9	26	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2020.115578
	5202	139	72	None	-9	26	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2020.115578
	CHEMBL39	139	72	None	-9	26	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2020.115578
	DB08839	139	72	None	-9	26	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2020.115578
	CHEMBL5091373	215567	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5095981	215567	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5091373	215567	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5095981	215567	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5091373	215567	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5095981	215567	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5091373	215567	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5095981	215567	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5077293	214491	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCNC2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL5077293	214491	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCNC2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL5074880	214339	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5074880	214339	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	11431530	84625	0	None	-	1	Guinea pig	5.1	pEC50	=	5.1	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	405	8	1	3	4.6	O=C(CCCCCN1CCN(c2ccccc2)CC1)NC1CCCc2ccccc21	10.1021/jm070487n
	CHEMBL222188	84625	0	None	-	1	Guinea pig	5.1	pEC50	=	5.1	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	405	8	1	3	4.6	O=C(CCCCCN1CCN(c2ccccc2)CC1)NC1CCCc2ccccc21	10.1021/jm070487n
	24825775	1523	14	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	3929	1523	14	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	CHEMBL4205349	1523	14	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	24825775	1523	14	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	3929	1523	14	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	CHEMBL4205349	1523	14	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	CHEMBL5074190	214314	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(CCN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL5074190	214314	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(CCN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	5	139	72	None	-9	26	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	5202	139	72	None	-9	26	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	CHEMBL39	139	72	None	-9	26	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	DB08839	139	72	None	-9	26	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	23643663	92844	0	None	-	1	Guinea pig	6.1	pEC50	=	6.1	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	447	9	1	3	5.7	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL243744	92844	0	None	-	1	Guinea pig	6.1	pEC50	=	6.1	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	447	9	1	3	5.7	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL5077293	214491	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCNC2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL5077293	214491	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCNC2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	3233	3512	44	None	8511	2	Human	9.3	pIC50	=	9.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	3247	3512	44	None	8511	2	Human	9.3	pIC50	=	9.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	6604889	3512	44	None	8511	2	Human	9.3	pIC50	=	9.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	CHEMBL282199	3512	44	None	8511	2	Human	9.3	pIC50	=	9.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	DB13988	3512	44	None	8511	2	Human	9.3	pIC50	=	9.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	4106	2502	22	None	-7	7	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysisAntagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmcl.2019.126703
	5358812	2502	22	None	-7	7	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysisAntagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmcl.2019.126703
	89	2502	22	None	-7	7	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysisAntagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmcl.2019.126703
	CHEMBL93240	2502	22	None	-7	7	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysisAntagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmcl.2019.126703
	3233	3512	44	None	8511	2	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	3247	3512	44	None	8511	2	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	6604889	3512	44	None	8511	2	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	CHEMBL282199	3512	44	None	8511	2	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	DB13988	3512	44	None	8511	2	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	3233	3512	44	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2018.04.059
	3247	3512	44	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2018.04.059
	6604889	3512	44	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2018.04.059
	CHEMBL282199	3512	44	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2018.04.059
	DB13988	3512	44	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2018.04.059
	3233	3512	44	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	3247	3512	44	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	6604889	3512	44	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	CHEMBL282199	3512	44	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	DB13988	3512	44	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	3233	3512	44	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	3247	3512	44	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	6604889	3512	44	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	CHEMBL282199	3512	44	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	DB13988	3512	44	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	4106	2502	22	None	-7	7	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulationAntagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulation	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm401895u
	5358812	2502	22	None	-7	7	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulationAntagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulation	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm401895u
	89	2502	22	None	-7	7	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulationAntagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulation	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm401895u
	CHEMBL93240	2502	22	None	-7	7	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulationAntagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulation	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm401895u
	164609529	184464	0	None	-36	2	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assayAntagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assay	ChEMBL	383	5	0	4	4.1	CC1(CCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O	10.1016/j.ejmech.2021.113243
	CHEMBL4846823	184464	0	None	-36	2	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assayAntagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assay	ChEMBL	383	5	0	4	4.1	CC1(CCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O	10.1016/j.ejmech.2021.113243
	11391654	180525	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Inverse agonist activity at 5-HT7 receptor (unknown origin) by cAMP functional assayInverse agonist activity at 5-HT7 receptor (unknown origin) by cAMP functional assay	ChEMBL	273	2	1	3	3.0	CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4753511	180525	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Inverse agonist activity at 5-HT7 receptor (unknown origin) by cAMP functional assayInverse agonist activity at 5-HT7 receptor (unknown origin) by cAMP functional assay	ChEMBL	273	2	1	3	3.0	CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	127028798	138184	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	454	6	2	5	2.4	Cc1ccc(C)c(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1	10.1016/j.ejmech.2016.02.024
	CHEMBL3769612	138184	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	454	6	2	5	2.4	Cc1ccc(C)c(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1	10.1016/j.ejmech.2016.02.024
	142601335	186421	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4876193	186421	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	145946966	167597	0	None	-144	3	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	354	7	0	4	3.9	COc1ccccc1N1CCN(CCCOc2ccc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4209888	167597	0	None	-144	3	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	354	7	0	4	3.9	COc1ccccc1N1CCN(CCCOc2ccc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4300899	167597	0	None	-144	3	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	354	7	0	4	3.9	COc1ccccc1N1CCN(CCCOc2ccc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	142601335	186421	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4876193	186421	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	4106	2502	22	None	-7	7	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assayAntagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assay	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2020.112709
	5358812	2502	22	None	-7	7	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assayAntagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assay	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2020.112709
	89	2502	22	None	-7	7	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assayAntagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assay	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2020.112709
	CHEMBL93240	2502	22	None	-7	7	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assayAntagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assay	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2020.112709
	117209912	185337	1	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4859827	185337	1	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	117209912	185337	1	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4859827	185337	1	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	135339817	181484	0	None	-1	5	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assayAntagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assay	ChEMBL	437	6	0	5	4.2	CN1CCc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2C1=O	10.1016/j.ejmech.2020.112709
	CHEMBL4764679	181484	0	None	-1	5	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assayAntagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assay	ChEMBL	437	6	0	5	4.2	CN1CCc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2C1=O	10.1016/j.ejmech.2020.112709
	206	2493	16	None	-97	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as inhibition of serotonon-induced increase in cAMP levels by HTRF assay relative to untreated controlAntagonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as inhibition of serotonon-induced increase in cAMP levels by HTRF assay relative to untreated control	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1021/jm8014553
	68848	2493	16	None	-97	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as inhibition of serotonon-induced increase in cAMP levels by HTRF assay relative to untreated controlAntagonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as inhibition of serotonon-induced increase in cAMP levels by HTRF assay relative to untreated control	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1021/jm8014553
	CHEMBL12314	2493	16	None	-97	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as inhibition of serotonon-induced increase in cAMP levels by HTRF assay relative to untreated controlAntagonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as inhibition of serotonon-induced increase in cAMP levels by HTRF assay relative to untreated control	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1021/jm8014553
	156013673	177261	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	293	1	2	2	2.9	CN1CCc2cccc3c2C1Cc1ccc(NC(N)=O)cc1-3	10.1016/j.bmc.2020.115578
	CHEMBL4636148	177261	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	293	1	2	2	2.9	CN1CCc2cccc3c2C1Cc1ccc(NC(N)=O)cc1-3	10.1016/j.bmc.2020.115578
	127028797	138333	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	494	6	2	5	3.1	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3cccc(Cl)c3Cl)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	CHEMBL3771309	138333	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	494	6	2	5	3.1	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3cccc(Cl)c3Cl)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	11536844	115122	0	None	2	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343672	115122	0	None	2	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	213046	2385	59	None	1	17	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assayAntagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assay	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.ejmech.2021.113243
	4168	2385	59	None	1	17	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assayAntagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assay	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.ejmech.2021.113243
	7461	2385	59	None	1	17	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assayAntagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assay	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.ejmech.2021.113243
	CHEMBL1237021	2385	59	None	1	17	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assayAntagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assay	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.ejmech.2021.113243
	DB08815	2385	59	None	1	17	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assayAntagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assay	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.ejmech.2021.113243
	142601318	185545	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4863036	185545	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	142601318	185545	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4863036	185545	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	11500509	120581	0	None	3	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343670	120581	0	None	3	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3545812	120581	0	None	3	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	117209962	184869	1	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	242	2	2	3	1.8	Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4852622	184869	1	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	242	2	2	3	1.8	Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	117209962	184869	1	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	242	2	2	3	1.8	Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4852622	184869	1	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	242	2	2	3	1.8	Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	142601343	185603	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	256	2	2	3	2.2	Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4863868	185603	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	256	2	2	3	2.2	Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	142601343	185603	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	256	2	2	3	2.2	Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4863868	185603	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	256	2	2	3	2.2	Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	127029652	138328	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	516	8	2	5	3.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	CHEMBL3771222	138328	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	516	8	2	5	3.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	145947937	167723	0	None	-32	4	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2c(C)cc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4207653	167723	0	None	-32	4	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2c(C)cc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4302655	167723	0	None	-32	4	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2c(C)cc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	134141985	147176	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	432	6	0	6	4.4	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)cc2c1OCO2	10.1016/j.ejmech.2016.07.029
	CHEMBL3927929	147176	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	432	6	0	6	4.4	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)cc2c1OCO2	10.1016/j.ejmech.2016.07.029
	134141985	147176	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	432	6	0	6	4.4	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)cc2c1OCO2	10.1016/j.ejmech.2016.07.029
	CHEMBL3927929	147176	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	432	6	0	6	4.4	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)cc2c1OCO2	10.1016/j.ejmech.2016.07.029
	44348383	16303	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	205	3	1	2	2.7	CSc1ccc2c(c1)C(CCN)=CC2	10.1016/j.ejmech.2012.11.042
	CHEMBL122536	16303	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	205	3	1	2	2.7	CSc1ccc2c(c1)C(CCN)=CC2	10.1016/j.ejmech.2012.11.042
	4106	2502	22	None	-7	7	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2016.02.024
	5358812	2502	22	None	-7	7	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2016.02.024
	89	2502	22	None	-7	7	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2016.02.024
	CHEMBL93240	2502	22	None	-7	7	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2016.02.024
	102364516	113543	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay	ChEMBL	346	6	0	2	4.0	O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1	10.1021/jm500880c
	CHEMBL3321794	113543	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay	ChEMBL	346	6	0	2	4.0	O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1	10.1021/jm500880c
	134157289	154081	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	422	6	0	4	5.3	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1Cl	10.1016/j.ejmech.2016.07.029
	CHEMBL3984812	154081	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	422	6	0	4	5.3	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1Cl	10.1016/j.ejmech.2016.07.029
	118709756	113547	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay	ChEMBL	352	6	0	2	4.4	O=C1Cc2ccccc2N1CC/C=C/CCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
	CHEMBL3321798	113547	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay	ChEMBL	352	6	0	2	4.4	O=C1Cc2ccccc2N1CC/C=C/CCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
	134157289	154081	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	422	6	0	4	5.3	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1Cl	10.1016/j.ejmech.2016.07.029
	CHEMBL3984812	154081	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	422	6	0	4	5.3	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1Cl	10.1016/j.ejmech.2016.07.029
	117209857	185138	1	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4856702	185138	1	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	142601328	185003	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4854605	185003	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	145946714	167558	0	None	-30	4	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2cc(C)cc(C)c2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4213352	167558	0	None	-30	4	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2cc(C)cc(C)c2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4300399	167558	0	None	-30	4	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2cc(C)cc(C)c2C)CC1	10.1016/j.bmcl.2018.04.059
	142601328	185003	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4854605	185003	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	117209857	185138	1	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4856702	185138	1	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	127029650	138266	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	494	6	2	5	3.1	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	CHEMBL3770581	138266	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	494	6	2	5	3.1	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	142601333	185763	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	260	2	2	3	2.0	Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4866412	185763	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	260	2	2	3	2.0	Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	142601328	185003	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assay	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4854605	185003	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assay	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	135367820	164821	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218672	164821	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	142601333	185763	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	260	2	2	3	2.0	Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4866412	185763	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	260	2	2	3	2.0	Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	142601328	185003	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assay	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4854605	185003	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assay	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	135367820	164821	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218672	164821	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	135367405	164196	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4210782	164196	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	135367405	164196	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4210782	164196	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	156010865	177131	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	307	0	1	4	3.6	CN1CCc2cccc3c2C1Cc1cc2sc(N)nc2cc1-3	10.1016/j.bmc.2020.115578
	CHEMBL4633786	177131	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	307	0	1	4	3.6	CN1CCc2cccc3c2C1Cc1cc2sc(N)nc2cc1-3	10.1016/j.bmc.2020.115578
	71574210	86283	0	None	2	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	478	7	1	5	4.0	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1	10.1016/j.ejmech.2012.11.042
	CHEMBL2312934	86283	0	None	2	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	478	7	1	5	4.0	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1	10.1016/j.ejmech.2012.11.042
	206	2493	16	None	-97	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1021/jm500880c
	68848	2493	16	None	-97	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1021/jm500880c
	CHEMBL12314	2493	16	None	-97	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1021/jm500880c
	3233	3512	44	None	8511	2	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	3247	3512	44	None	8511	2	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	6604889	3512	44	None	8511	2	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	CHEMBL282199	3512	44	None	8511	2	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	DB13988	3512	44	None	8511	2	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	3233	3512	44	None	8511	2	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	3247	3512	44	None	8511	2	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	6604889	3512	44	None	8511	2	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	CHEMBL282199	3512	44	None	8511	2	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	DB13988	3512	44	None	8511	2	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	2470	3653	50	None	-5128	23	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.bmc.2020.115578
	3300	3653	50	None	-5128	23	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.bmc.2020.115578
	5265	3653	50	None	-5128	23	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.bmc.2020.115578
	99	3653	50	None	-5128	23	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.bmc.2020.115578
	CHEMBL267930	3653	50	None	-5128	23	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.bmc.2020.115578
	127028473	138273	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	451	6	2	6	1.6	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	CHEMBL3770639	138273	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	451	6	2	6	1.6	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	86288948	112626	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2016.02.024
	CHEMBL3233679	112626	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2016.02.024
	CHEMBL3302600	112626	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2016.02.024
	71574302	86264	0	None	-4	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1	10.1016/j.ejmech.2012.11.042
	CHEMBL2312637	86264	0	None	-4	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1	10.1016/j.ejmech.2012.11.042
	142601323	185841	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1ccccc1-c1n[nH]cc1N1CCCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4867560	185841	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1ccccc1-c1n[nH]cc1N1CCCNCC1	10.1021/acs.jmedchem.1c01093
	135367816	164835	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218801	164835	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	117209971	186485	1	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4877051	186485	1	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	135367816	164835	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218801	164835	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	142601323	185841	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1ccccc1-c1n[nH]cc1N1CCCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4867560	185841	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1ccccc1-c1n[nH]cc1N1CCCNCC1	10.1021/acs.jmedchem.1c01093
	117209971	186485	1	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4877051	186485	1	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	117209918	186410	1	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4876036	186410	1	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	117209918	186410	1	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4876036	186410	1	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	11536843	115123	0	None	1	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343673	115123	0	None	1	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	22001618	81813	10	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISAAntagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISA	ChEMBL	268	3	1	3	2.8	COc1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
	CHEMBL2164336	81813	10	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISAAntagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISA	ChEMBL	268	3	1	3	2.8	COc1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
	59511191	185523	3	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	228	2	2	3	1.5	c1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4862745	185523	3	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	228	2	2	3	1.5	c1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	59511191	185523	3	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	228	2	2	3	1.5	c1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4862745	185523	3	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	228	2	2	3	1.5	c1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	2737389	187586	28	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISAAntagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISA	ChEMBL	238	2	1	2	2.8	c1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
	CHEMBL494675	187586	28	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISAAntagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISA	ChEMBL	238	2	1	2	2.8	c1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
	90656694	110995	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated cAMP accumulationAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated cAMP accumulation	ChEMBL	339	7	1	4	3.4	CN(CCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262428	110995	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated cAMP accumulationAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated cAMP accumulation	ChEMBL	339	7	1	4	3.4	CN(CCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	117209911	186329	1	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4874854	186329	1	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	117209911	186329	1	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4874854	186329	1	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	134154531	152728	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	418	7	0	5	4.7	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OC	10.1016/j.ejmech.2016.07.029
	CHEMBL3973160	152728	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	418	7	0	5	4.7	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OC	10.1016/j.ejmech.2016.07.029
	71574306	86266	0	None	2	2	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2cn1	10.1016/j.ejmech.2012.11.042
	CHEMBL2312639	86266	0	None	2	2	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2cn1	10.1016/j.ejmech.2012.11.042
	134154531	152728	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	418	7	0	5	4.7	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OC	10.1016/j.ejmech.2016.07.029
	CHEMBL3973160	152728	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	418	7	0	5	4.7	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OC	10.1016/j.ejmech.2016.07.029
	145947560	167708	0	None	-19	4	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	344	6	0	3	4.2	Cc1cc(OCCCN2CCN(c3ccccc3)CC2)ccc1Cl	10.1016/j.bmcl.2018.04.059
	CHEMBL4212812	167708	0	None	-19	4	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	344	6	0	3	4.2	Cc1cc(OCCCN2CCN(c3ccccc3)CC2)ccc1Cl	10.1016/j.bmcl.2018.04.059
	CHEMBL4302457	167708	0	None	-19	4	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	344	6	0	3	4.2	Cc1cc(OCCCN2CCN(c3ccccc3)CC2)ccc1Cl	10.1016/j.bmcl.2018.04.059
	11694810	120539	0	None	-1	2	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemInhibition of human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	CHEMBL3310123	120539	0	None	-1	2	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemInhibition of human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	CHEMBL3545474	120539	0	None	-1	2	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemInhibition of human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	127028153	138163	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	456	7	2	6	1.8	COc1cccc(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1	10.1016/j.ejmech.2016.02.024
	CHEMBL3769441	138163	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	456	7	2	6	1.8	COc1cccc(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1	10.1016/j.ejmech.2016.02.024
	142601325	185869	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	242	2	2	3	1.9	c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4868035	185869	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	242	2	2	3	1.9	c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	142601325	185869	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	242	2	2	3	1.9	c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4868035	185869	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	242	2	2	3	1.9	c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	117209964	186134	1	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4871980	186134	1	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	134137104	142692	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	402	6	0	4	5.0	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1C	10.1016/j.ejmech.2016.07.029
	CHEMBL3892079	142692	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	402	6	0	4	5.0	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1C	10.1016/j.ejmech.2016.07.029
	134137104	142692	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	402	6	0	4	5.0	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1C	10.1016/j.ejmech.2016.07.029
	CHEMBL3892079	142692	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	402	6	0	4	5.0	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1C	10.1016/j.ejmech.2016.07.029
	117209964	186134	1	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4871980	186134	1	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	155510732	169520	0	None	1	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysisAntagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysis	ChEMBL	430	6	1	1	6.9	Fc1ccc(C2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccccc2)c1	10.1016/j.bmcl.2019.126703
	CHEMBL4434876	169520	0	None	1	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysisAntagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysis	ChEMBL	430	6	1	1	6.9	Fc1ccc(C2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccccc2)c1	10.1016/j.bmcl.2019.126703
	142601329	186517	5	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	276	2	2	3	2.5	Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4877603	186517	5	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	276	2	2	3	2.5	Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	142601329	186517	5	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	276	2	2	3	2.5	Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4877603	186517	5	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	276	2	2	3	2.5	Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	124247485	164069	8	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4209274	164069	8	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	124247485	164069	8	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4209274	164069	8	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	142601337	185970	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	260	2	2	3	2.0	Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4869695	185970	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	260	2	2	3	2.0	Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	142601337	185970	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	260	2	2	3	2.0	Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4869695	185970	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	260	2	2	3	2.0	Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	142601335	186421	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assay	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4876193	186421	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assay	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	142601335	186421	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assay	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4876193	186421	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assay	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	67268994	163968	2	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4207884	163968	2	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	67268994	163968	2	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4207884	163968	2	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	71574212	86284	0	None	-4	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccccc2c1	10.1016/j.ejmech.2012.11.042
	CHEMBL2312935	86284	0	None	-4	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccccc2c1	10.1016/j.ejmech.2012.11.042
	127028472	138171	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	470	8	2	6	2.2	CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2016.02.024
	CHEMBL3769534	138171	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	470	8	2	6	2.2	CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2016.02.024
	71574204	86267	0	None	18	2	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cncc2ccccc12	10.1016/j.ejmech.2012.11.042
	CHEMBL2312640	86267	0	None	18	2	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cncc2ccccc12	10.1016/j.ejmech.2012.11.042
	135367857	164604	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4215875	164604	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	135367857	164604	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4215875	164604	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	117209864	186034	1	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4870675	186034	1	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	117209864	186034	1	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4870675	186034	1	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	117209965	185247	1	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4858338	185247	1	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	142601341	185372	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4860503	185372	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	117209965	185247	1	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4858338	185247	1	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	142601341	185372	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4860503	185372	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	117209858	184554	1	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4848305	184554	1	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	117209858	184554	1	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4848305	184554	1	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	3233	3512	44	None	-	2	Guinea pig	8.0	pKd	=	8.0	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	3247	3512	44	None	-	2	Guinea pig	8.0	pKd	=	8.0	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	6604889	3512	44	None	-	2	Guinea pig	8.0	pKd	=	8.0	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	CHEMBL282199	3512	44	None	-	2	Guinea pig	8.0	pKd	=	8.0	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	DB13988	3512	44	None	-	2	Guinea pig	8.0	pKd	=	8.0	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	3233	3512	44	None	-	2	Guinea pig	7.9	pKd	=	7.9	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3247	3512	44	None	-	2	Guinea pig	7.9	pKd	=	7.9	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	6604889	3512	44	None	-	2	Guinea pig	7.9	pKd	=	7.9	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	CHEMBL282199	3512	44	None	-	2	Guinea pig	7.9	pKd	=	7.9	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	DB13988	3512	44	None	-	2	Guinea pig	7.9	pKd	=	7.9	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3233	3512	44	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	3247	3512	44	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	6604889	3512	44	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	CHEMBL282199	3512	44	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	DB13988	3512	44	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	3233	3512	44	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3247	3512	44	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	6604889	3512	44	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	CHEMBL282199	3512	44	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	DB13988	3512	44	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3233	3512	44	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	3247	3512	44	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	6604889	3512	44	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	CHEMBL282199	3512	44	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	DB13988	3512	44	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	24768520	93007	0	None	-	0	Guinea pig	7.7	pKd	=	7.7	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on substance P-induced contraction	ChEMBL	434	9	2	4	4.6	CNc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL244161	93007	0	None	-	0	Guinea pig	7.7	pKd	=	7.7	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on substance P-induced contraction	ChEMBL	434	9	2	4	4.6	CNc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	3233	3512	44	None	-	2	Guinea pig	7.7	pKd	=	7.7	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	3247	3512	44	None	-	2	Guinea pig	7.7	pKd	=	7.7	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	6604889	3512	44	None	-	2	Guinea pig	7.7	pKd	=	7.7	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	CHEMBL282199	3512	44	None	-	2	Guinea pig	7.7	pKd	=	7.7	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	DB13988	3512	44	None	-	2	Guinea pig	7.7	pKd	=	7.7	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	3233	3512	44	None	-	2	Guinea pig	8.4	pKd	=	8.4	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3247	3512	44	None	-	2	Guinea pig	8.4	pKd	=	8.4	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	6604889	3512	44	None	-	2	Guinea pig	8.4	pKd	=	8.4	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	CHEMBL282199	3512	44	None	-	2	Guinea pig	8.4	pKd	=	8.4	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	DB13988	3512	44	None	-	2	Guinea pig	8.4	pKd	=	8.4	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3233	3512	44	None	-	2	Guinea pig	7.5	pKd	=	7.5	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	3247	3512	44	None	-	2	Guinea pig	7.5	pKd	=	7.5	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	6604889	3512	44	None	-	2	Guinea pig	7.5	pKd	=	7.5	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	CHEMBL282199	3512	44	None	-	2	Guinea pig	7.5	pKd	=	7.5	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	DB13988	3512	44	None	-	2	Guinea pig	7.5	pKd	=	7.5	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	3233	3512	44	None	-	2	Guinea pig	7.5	pKd	=	7.5	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3247	3512	44	None	-	2	Guinea pig	7.5	pKd	=	7.5	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	6604889	3512	44	None	-	2	Guinea pig	7.5	pKd	=	7.5	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	CHEMBL282199	3512	44	None	-	2	Guinea pig	7.5	pKd	=	7.5	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	DB13988	3512	44	None	-	2	Guinea pig	7.5	pKd	=	7.5	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3233	3512	44	None	-	2	Guinea pig	8.2	pKd	=	8.2	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3247	3512	44	None	-	2	Guinea pig	8.2	pKd	=	8.2	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	6604889	3512	44	None	-	2	Guinea pig	8.2	pKd	=	8.2	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	CHEMBL282199	3512	44	None	-	2	Guinea pig	8.2	pKd	=	8.2	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	DB13988	3512	44	None	-	2	Guinea pig	8.2	pKd	=	8.2	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3233	3512	44	None	-	2	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3247	3512	44	None	-	2	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	6604889	3512	44	None	-	2	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	CHEMBL282199	3512	44	None	-	2	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	DB13988	3512	44	None	-	2	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3233	3512	44	None	-	2	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3247	3512	44	None	-	2	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	6604889	3512	44	None	-	2	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	CHEMBL282199	3512	44	None	-	2	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	DB13988	3512	44	None	-	2	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	118731356	118192	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Agonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to controlAgonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to control	ChEMBL	502	8	0	4	4.6	O=C([C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409039	118192	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Agonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to controlAgonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to control	ChEMBL	502	8	0	4	4.6	O=C([C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	4806	4008	88	None	-	3	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assayAntagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assay	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
	7351	4008	88	None	-	3	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assayAntagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assay	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
	9966051	4008	88	None	-	3	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assayAntagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assay	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
	CHEMBL2104993	4008	88	None	-	3	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assayAntagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assay	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
	DB09068	4008	88	None	-	3	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assayAntagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assay	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
	118731351	118188	0	None	-	0	Human	8.2	pKi	=	8.2	Functional	Agonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to controlAgonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to control	ChEMBL	496	8	1	4	4.1	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409035	118188	0	None	-	0	Human	8.2	pKi	=	8.2	Functional	Agonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to controlAgonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to control	ChEMBL	496	8	1	4	4.1	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
	118731356	118192	0	None	-	0	Human	7.0	pKi	=	7.0	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to controlAntagonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to control	ChEMBL	502	8	0	4	4.6	O=C([C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409039	118192	0	None	-	0	Human	7.0	pKi	=	7.0	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to controlAntagonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to control	ChEMBL	502	8	0	4	4.6	O=C([C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	118731351	118188	0	None	-	0	Human	7.0	pKi	=	7.0	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to controlAntagonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to control	ChEMBL	496	8	1	4	4.1	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409035	118188	0	None	-	0	Human	7.0	pKi	=	7.0	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to controlAntagonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to control	ChEMBL	496	8	1	4	4.1	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
	240	944	43	None	-1	22	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	2769	944	43	None	-1	22	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	44279790	944	43	None	-1	22	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	660	944	43	None	-1	22	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	CHEMBL1729	944	43	None	-1	22	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	CHEMBL560739	944	43	None	-1	22	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	DB00604	944	43	None	-1	22	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	4223	3992	94	None	-562	16	Rat	8.3	pIC50	=	8.3	Functional	Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	6918314	3992	94	None	-562	16	Rat	8.3	pIC50	=	8.3	Functional	Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	7427	3992	94	None	-562	16	Rat	8.3	pIC50	=	8.3	Functional	Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	CHEMBL439849	3992	94	None	-562	16	Rat	8.3	pIC50	=	8.3	Functional	Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	DB06684	3992	94	None	-562	16	Rat	8.3	pIC50	=	8.3	Functional	Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Similar- ity	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
		135398737	958	93	None	-13	89	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		38	958	93	None	-13	89	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		722	958	93	None	-13	89	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL42	958	93	None	-13	89	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		DB00363	958	93	None	-13	89	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		3158	56267	27	None	-	20	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1628227	56267	27	None	-	20	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
		2585	803	103	None	-	21	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		522	803	103	None	-	21	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		551	803	103	None	-	21	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		CHEMBL723	803	103	None	-	21	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		DB01136	803	103	None	-	21	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		2247	505	81	None	-	42	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		249	505	81	None	-	42	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		2603	505	81	None	-	42	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		CHEMBL296419	505	81	None	-	42	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		DB00637	505	81	None	-	42	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		2284	3182	33	None	-	29	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		4926	3182	33	None	-	29	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		7281	3182	33	None	-	29	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL564	3182	33	None	-	29	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		DB00420	3182	33	None	-	29	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		2337	3256	77	None	-28	62	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		50	3256	77	None	-28	62	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		5002	3256	77	None	-28	62	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL716	3256	77	None	-28	62	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		DB01224	3256	77	None	-28	62	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		1890	2759	49	None	-	16	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		4449	2759	49	None	-	16	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		7247	2759	49	None	-	16	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		CHEMBL623	2759	49	None	-	16	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		DB01149	2759	49	None	-	16	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		212	3806	47	None	-7	25	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		2639	3806	47	None	-7	25	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		941651	3806	47	None	-7	25	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		CHEMBL1201	3806	47	None	-7	25	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		DB01623	3806	47	None	-7	25	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		2389	3331	118	None	-8	67	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		5073	3331	118	None	-8	67	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		96	3331	118	None	-8	67	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		CHEMBL85	3331	118	None	-8	67	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		DB00734	3331	118	None	-8	67	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		135	2532	43	None	-83	58	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		1796	2532	43	None	-83	58	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		4184	2532	43	None	-83	58	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		CHEMBL6437	2532	43	None	-83	58	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		DB06148	2532	43	None	-83	58	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		2543	3707	68	None	-93	32	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
		5358	3707	68	None	-93	32	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
		54	3707	68	None	-93	32	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
		CHEMBL128	3707	68	None	-93	32	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
		DB00669	3707	68	None	-93	32	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
		191	403	98	None	-41	29	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		201	403	98	None	-41	29	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		2170	403	98	None	-41	29	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		CHEMBL1113	403	98	None	-41	29	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		DB00543	403	98	None	-41	29	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		135398745	2914	112	None	-95	65	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		47	2914	112	None	-95	65	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL715	2914	112	None	-95	65	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		DB00334	2914	112	None	-95	65	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		1400	1957	70	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		3658	1957	70	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		7199	1957	70	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		91513	1957	70	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL896	1957	70	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		DB00557	1957	70	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		2726	919	68	None	-13	72	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		621	919	68	None	-13	72	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		83	919	68	None	-13	72	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		CHEMBL71	919	68	None	-13	72	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		DB00477	919	68	None	-13	72	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		1613	2348	53	None	-23	44	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		205	2348	53	None	-23	44	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		3964	2348	53	None	-23	44	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		CHEMBL831	2348	53	None	-23	44	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		DB00408	2348	53	None	-23	44	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		135409453	3773	41	None	-	2	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		226	3773	41	None	-	2	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		CHEMBL76370	3773	41	None	-	2	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		1353	1911	93	None	-263	83	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		3559	1911	93	None	-263	83	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		86	1911	93	None	-263	83	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		CHEMBL54	1911	93	None	-263	83	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		DB00502	1911	93	None	-263	83	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		392622	56312	95	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	10.1038/s41467-023-40064-9
		CHEMBL163	56312	95	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	10.1038/s41467-023-40064-9
		4106	2502	22	None	-4	34	Human	9.2	pEC50	=	9.2	Binding	Displacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/np058114h
		5358812	2502	22	None	-4	34	Human	9.2	pEC50	=	9.2	Binding	Displacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/np058114h
		89	2502	22	None	-4	34	Human	9.2	pEC50	=	9.2	Binding	Displacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/np058114h
		CHEMBL93240	2502	22	None	-4	34	Human	9.2	pEC50	=	9.2	Binding	Displacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/np058114h
		5	139	72	None	-3	54	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2019.07.046
		5202	139	72	None	-3	54	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2019.07.046
		CHEMBL39	139	72	None	-3	54	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2019.07.046
		DB08839	139	72	None	-3	54	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2019.07.046
		5	139	72	None	-3	54	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2019.07.046
		5202	139	72	None	-3	54	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2019.07.046
		CHEMBL39	139	72	None	-3	54	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2019.07.046
		DB08839	139	72	None	-3	54	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2019.07.046
		5	139	72	None	-3	54	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2016.03.006
		5202	139	72	None	-3	54	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2016.03.006
		CHEMBL39	139	72	None	-3	54	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2016.03.006
		DB08839	139	72	None	-3	54	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2016.03.006
		5	139	72	None	-3	54	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting method	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2016.11.014
		5202	139	72	None	-3	54	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting method	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2016.11.014
		CHEMBL39	139	72	None	-3	54	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting method	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2016.11.014
		DB08839	139	72	None	-3	54	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting method	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2016.11.014
		5	139	72	None	-3	54	Human	9.5	pIC50	=	9.5	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2013.01.044
		5202	139	72	None	-3	54	Human	9.5	pIC50	=	9.5	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2013.01.044
		CHEMBL39	139	72	None	-3	54	Human	9.5	pIC50	=	9.5	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2013.01.044
		DB08839	139	72	None	-3	54	Human	9.5	pIC50	=	9.5	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2013.01.044
		72548703	161567	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
		CHEMBL4128926	161567	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
		5	139	72	None	-3	54	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01422
		5202	139	72	None	-3	54	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01422
		CHEMBL39	139	72	None	-3	54	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01422
		DB08839	139	72	None	-3	54	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01422
		5	139	72	None	-3	54	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2013.03.016
		5202	139	72	None	-3	54	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2013.03.016
		CHEMBL39	139	72	None	-3	54	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2013.03.016
		DB08839	139	72	None	-3	54	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2013.03.016
		5	139	72	None	-3	54	Human	9.2	pIC50	=	9.2	Binding	Displacement of radiolabeled serotonin from human 5HT7 receptorDisplacement of radiolabeled serotonin from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8007618
		5202	139	72	None	-3	54	Human	9.2	pIC50	=	9.2	Binding	Displacement of radiolabeled serotonin from human 5HT7 receptorDisplacement of radiolabeled serotonin from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8007618
		CHEMBL39	139	72	None	-3	54	Human	9.2	pIC50	=	9.2	Binding	Displacement of radiolabeled serotonin from human 5HT7 receptorDisplacement of radiolabeled serotonin from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8007618
		DB08839	139	72	None	-3	54	Human	9.2	pIC50	=	9.2	Binding	Displacement of radiolabeled serotonin from human 5HT7 receptorDisplacement of radiolabeled serotonin from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8007618
		5	139	72	None	-3	54	Human	8.8	pIC50	=	8.8	Binding	Inhibition of human 5HT7 receptorInhibition of human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm701575k
		5202	139	72	None	-3	54	Human	8.8	pIC50	=	8.8	Binding	Inhibition of human 5HT7 receptorInhibition of human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm701575k
		CHEMBL39	139	72	None	-3	54	Human	8.8	pIC50	=	8.8	Binding	Inhibition of human 5HT7 receptorInhibition of human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm701575k
		DB08839	139	72	None	-3	54	Human	8.8	pIC50	=	8.8	Binding	Inhibition of human 5HT7 receptorInhibition of human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm701575k
		11430418	18786	12	None	-	1	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	432	6	1	7	2.5	Nn1c(CCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2c(c1=O)CCCC2	10.1021/jm1002292
		CHEMBL1278088	18786	12	None	-	1	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	432	6	1	7	2.5	Nn1c(CCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2c(c1=O)CCCC2	10.1021/jm1002292
		44452114	160803	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		CHEMBL411442	160803	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		44452114	160803	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		CHEMBL411442	160803	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		72197486	102503	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	364	4	2	4	4.2	Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
		CHEMBL2393245	102503	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	364	4	2	4	4.2	Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
		CHEMBL3040361	102503	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	364	4	2	4	4.2	Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
		49864602	15664	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	373	5	0	4	3.0	CC(C)N(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccccc1	10.1016/j.bmcl.2010.06.150
		CHEMBL1222138	15664	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	373	5	0	4	3.0	CC(C)N(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccccc1	10.1016/j.bmcl.2010.06.150
		44576978	187272	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	457	8	1	5	3.5	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)cc1	10.1016/j.bmc.2008.04.023
		CHEMBL492793	187272	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	457	8	1	5	3.5	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)cc1	10.1016/j.bmc.2008.04.023
		72197485	102489	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	348	4	2	4	3.6	Fc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
		CHEMBL2393244	102489	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	348	4	2	4	3.6	Fc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
		CHEMBL3040288	102489	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	348	4	2	4	3.6	Fc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
		42635388	187698	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	471	8	1	5	3.6	COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3cccc(C(F)(F)F)c3)CC2)cc1	10.1016/j.bmc.2008.04.023
		CHEMBL495250	187698	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	471	8	1	5	3.6	COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3cccc(C(F)(F)F)c3)CC2)cc1	10.1016/j.bmc.2008.04.023
		44452277	96079	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		CHEMBL260073	96079	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		44452245	96146	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.ejmech.2008.09.050
		CHEMBL260514	96146	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.ejmech.2008.09.050
		44452251	96235	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	495	7	1	6	3.8	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.ejmech.2008.09.050
		CHEMBL260901	96235	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	495	7	1	6	3.8	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.ejmech.2008.09.050
		44452219	161237	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	COc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
		CHEMBL411868	161237	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	COc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
		54576142	66495	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of 5HT7 receptor by competition binding assayInhibition of 5HT7 receptor by competition binding assay	ChEMBL	485	7	1	5	4.7	Cc1nc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1	10.1021/jm200682b
		CHEMBL1852341	66495	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of 5HT7 receptor by competition binding assayInhibition of 5HT7 receptor by competition binding assay	ChEMBL	485	7	1	5	4.7	Cc1nc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1	10.1021/jm200682b
		CHEMBL3216098	66495	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of 5HT7 receptor by competition binding assayInhibition of 5HT7 receptor by competition binding assay	ChEMBL	485	7	1	5	4.7	Cc1nc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1	10.1021/jm200682b
		24882509	96239	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	543	10	1	7	4.1	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
		CHEMBL260907	96239	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	543	10	1	7	4.1	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
		44452277	96079	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		CHEMBL260073	96079	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		44452245	96146	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.bmc.2007.11.049
		CHEMBL260514	96146	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.bmc.2007.11.049
		46232586	200922	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	473	9	0	4	4.6	O=S(=O)(c1ccc(F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
		CHEMBL601659	200922	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	473	9	0	4	4.6	O=S(=O)(c1ccc(F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
		44452251	96235	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	495	7	1	6	3.8	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.bmc.2007.11.049
		CHEMBL260901	96235	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	495	7	1	6	3.8	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.bmc.2007.11.049
		44452219	161237	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	COc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
		CHEMBL411868	161237	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	COc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
		135	2532	43	None	-83	58	Human	6.9	pIC50	=	6.9	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptorBinding affinity for human cloned 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
		1796	2532	43	None	-83	58	Human	6.9	pIC50	=	6.9	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptorBinding affinity for human cloned 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
		4184	2532	43	None	-83	58	Human	6.9	pIC50	=	6.9	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptorBinding affinity for human cloned 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
		CHEMBL6437	2532	43	None	-83	58	Human	6.9	pIC50	=	6.9	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptorBinding affinity for human cloned 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
		DB06148	2532	43	None	-83	58	Human	6.9	pIC50	=	6.9	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptorBinding affinity for human cloned 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
		46232818	200981	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	9	0	4	4.5	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
		CHEMBL602060	200981	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	9	0	4	4.5	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
		11113605	10507	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	480	9	0	2	5.8	O=C(CCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
		CHEMBL116735	10507	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	480	9	0	2	5.8	O=C(CCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
		44451927	96027	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
		CHEMBL259776	96027	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
		44452038	96241	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		CHEMBL260969	96241	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		155561990	175711	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	557	11	1	7	4.5	CCOc1ccccc1N1CCN(CCCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2019.111705
		CHEMBL4582321	175711	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	557	11	1	7	4.5	CCOc1ccccc1N1CCN(CCCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2019.111705
		24882509	96239	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	543	10	1	7	4.1	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
		CHEMBL260907	96239	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	543	10	1	7	4.1	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
		42635204	187759	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	477	7	1	4	4.3	O=S(=O)(NCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
		CHEMBL495678	187759	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	477	7	1	4	4.3	O=S(=O)(NCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
		46232860	201061	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	494	10	0	6	3.9	COc1ccccc1N1CCN(CCCN(CC2CC2)S(=O)(=O)c2cccc3cccnc23)CC1	10.1016/j.bmc.2009.12.067
		CHEMBL602677	201061	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	494	10	0	6	3.9	COc1ccccc1N1CCN(CCCN(CC2CC2)S(=O)(=O)c2cccc3cccnc23)CC1	10.1016/j.bmc.2009.12.067
		44451927	96027	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
		CHEMBL259776	96027	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
		44452038	96241	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		CHEMBL260969	96241	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		46232771	200855	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	443	10	0	5	3.3	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CC2)cc1	10.1016/j.bmc.2009.12.067
		CHEMBL601249	200855	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	443	10	0	5	3.3	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CC2)cc1	10.1016/j.bmc.2009.12.067
		10067306	198866	0	None	-	1	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells	ChEMBL	363	5	0	5	3.1	CN(C)CCn1cc(S(=O)(=O)c2cccc(Cl)c2)c2cccnc21	10.1016/j.bmc.2009.05.055
		CHEMBL584046	198866	0	None	-	1	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells	ChEMBL	363	5	0	5	3.1	CN(C)CCn1cc(S(=O)(=O)c2cccc(Cl)c2)c2cccnc21	10.1016/j.bmc.2009.05.055
		46232622	200717	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	505	9	0	4	5.6	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
		CHEMBL600012	200717	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	505	9	0	4	5.6	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
		42635387	187692	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	477	7	1	4	4.6	O=S(=O)(NCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
		CHEMBL495212	187692	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	477	7	1	4	4.6	O=S(=O)(NCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
		46232773	200951	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	511	10	0	5	4.3	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC2CC2)cc1	10.1016/j.bmc.2009.12.067
		CHEMBL601855	200951	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	511	10	0	5	4.3	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC2CC2)cc1	10.1016/j.bmc.2009.12.067
		44452278	96080	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		CHEMBL260074	96080	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		44452039	96242	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		CHEMBL260970	96242	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		44452278	96080	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		CHEMBL260074	96080	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		44452039	96242	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		CHEMBL260970	96242	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		44451930	95763	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1	10.1016/j.bmc.2007.11.049
		CHEMBL258524	95763	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1	10.1016/j.bmc.2007.11.049
		44451930	95763	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1	10.1016/j.ejmech.2008.09.050
		CHEMBL258524	95763	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1	10.1016/j.ejmech.2008.09.050
		10472158	196825	0	None	-	1	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells	ChEMBL	335	4	1	5	2.5	NCCn1cc(S(=O)(=O)c2cccc(Cl)c2)c2cccnc21	10.1016/j.bmc.2009.05.055
		CHEMBL565745	196825	0	None	-	1	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells	ChEMBL	335	4	1	5	2.5	NCCn1cc(S(=O)(=O)c2cccc(Cl)c2)c2cccnc21	10.1016/j.bmc.2009.05.055
		44452223	95991	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	497	8	1	7	3.2	COc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.ejmech.2008.09.050
		CHEMBL259625	95991	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	497	8	1	7	3.2	COc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.ejmech.2008.09.050
		42388965	187535	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	427	7	1	4	3.5	O=S(=O)(NCCCN1CCN(c2ccccc2F)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
		CHEMBL494428	187535	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	427	7	1	4	3.5	O=S(=O)(NCCCN1CCN(c2ccccc2F)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
		44452223	95991	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	497	8	1	7	3.2	COc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.bmc.2007.11.049
		CHEMBL259625	95991	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	497	8	1	7	3.2	COc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.bmc.2007.11.049
		53320009	56663	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in cells	ChEMBL	435	3	0	5	3.4	CN1CCN(c2ccc3c(c2)N(S(=O)(=O)c2ccc4ccccc4c2)CCC3=O)CC1	10.1016/j.bmcl.2010.12.007
		CHEMBL1642116	56663	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in cells	ChEMBL	435	3	0	5	3.4	CN1CCN(c2ccc3c(c2)N(S(=O)(=O)c2ccc4ccccc4c2)CCC3=O)CC1	10.1016/j.bmcl.2010.12.007
		169713	80161	20	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	309	3	2	2	2.6	CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2NC1	10.1016/j.bmcl.2009.09.002
		CHEMBL21343	80161	20	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	309	3	2	2	2.6	CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2NC1	10.1016/j.bmcl.2009.09.002
		11047568	10056	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	396	9	0	4	4.0	CCOc1ccc(CCOC(=O)N2CCN(CCCc3ccccc3)CC2)cc1	10.1021/jm010878g
		CHEMBL115249	10056	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	396	9	0	4	4.0	CCOc1ccc(CCOC(=O)N2CCN(CCCc3ccccc3)CC2)cc1	10.1021/jm010878g
		10885636	111016	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	503	9	0	4	5.7	N#Cc1ccc(CCOC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
		CHEMBL326263	111016	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	503	9	0	4	5.7	N#Cc1ccc(CCOC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
		46232732	200925	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	431	9	0	4	3.4	O=S(=O)(c1ccc(F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
		CHEMBL601673	200925	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	431	9	0	4	3.4	O=S(=O)(c1ccc(F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
		44452276	159934	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.ejmech.2008.09.050
		CHEMBL410722	159934	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.ejmech.2008.09.050
		44452276	159934	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.bmc.2007.11.049
		CHEMBL410722	159934	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.bmc.2007.11.049
		12	1553	17	None	-13	7	Human	5.8	pIC50	=	5.8	Binding	Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human	ChEMBL	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10.1016/j.bmcl.2005.06.067
		6918513	1553	17	None	-13	7	Human	5.8	pIC50	=	5.8	Binding	Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human	ChEMBL	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10.1016/j.bmcl.2005.06.067
		CHEMBL267615	1553	17	None	-13	7	Human	5.8	pIC50	=	5.8	Binding	Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human	ChEMBL	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10.1016/j.bmcl.2005.06.067
		46232653	201019	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	523	9	0	4	5.8	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
		CHEMBL602284	201019	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	523	9	0	4	5.8	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
		46232730	200891	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	9	0	4	4.5	O=S(=O)(c1cccc2ccccc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
		CHEMBL601457	200891	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	9	0	4	4.5	O=S(=O)(c1cccc2ccccc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
		72197484	102494	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	330	4	2	4	3.5	c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1	10.1016/j.ejmech.2013.02.020
		CHEMBL2393243	102494	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	330	4	2	4	3.5	c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1	10.1016/j.ejmech.2013.02.020
		CHEMBL3040324	102494	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	330	4	2	4	3.5	c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1	10.1016/j.ejmech.2013.02.020
		18180076	15602	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	381	4	1	4	3.4	CN1CCN(c2cccc(NS(=O)(=O)c3ccc4ccccc4c3)c2)CC1	10.1016/j.bmcl.2010.06.150
		CHEMBL1221497	15602	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	381	4	1	4	3.4	CN1CCN(c2cccc(NS(=O)(=O)c3ccc4ccccc4c3)c2)CC1	10.1016/j.bmcl.2010.06.150
		44452247	96187	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	549	8	1	6	4.9	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		CHEMBL260706	96187	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	549	8	1	6	4.9	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		44452115	96378	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.bmc.2007.11.049
		CHEMBL261742	96378	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.bmc.2007.11.049
		44451980	156021	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.bmc.2007.11.049
		CHEMBL406221	156021	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.bmc.2007.11.049
		44452115	96378	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.ejmech.2008.09.050
		CHEMBL261742	96378	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.ejmech.2008.09.050
		44451980	156021	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.ejmech.2008.09.050
		CHEMBL406221	156021	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.ejmech.2008.09.050
		44452247	96187	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	549	8	1	6	4.9	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		CHEMBL260706	96187	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	549	8	1	6	4.9	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		46232690	200960	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	574	9	0	5	6.0	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
		CHEMBL601886	200960	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	574	9	0	5	6.0	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
		155568606	176108	0	None	-3	2	Human	6.8	pIC50	=	6.8	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	532	9	1	6	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
		CHEMBL4591601	176108	0	None	-3	2	Human	6.8	pIC50	=	6.8	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	532	9	1	6	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
		155568606	176108	0	None	-3	2	Human	6.8	pIC50	=	6.8	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	532	9	1	6	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
		CHEMBL4591601	176108	0	None	-3	2	Human	6.8	pIC50	=	6.8	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	532	9	1	6	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
		11957735	200021	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	350	4	1	5	4.0	CN(C)Cc1nc(-c2ccc(C(C)(C)C)cc2)n(-c2cccc(O)c2)n1	10.1016/j.bmc.2009.07.007
		CHEMBL595449	200021	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	350	4	1	5	4.0	CN(C)Cc1nc(-c2ccc(C(C)(C)C)cc2)n(-c2cccc(O)c2)n1	10.1016/j.bmc.2009.07.007
		46232589	200813	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	515	11	0	6	4.5	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3OC)CC2)CC2CCCCC2)cc1	10.1016/j.bmc.2009.12.067
		CHEMBL600822	200813	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	515	11	0	6	4.5	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3OC)CC2)CC2CCCCC2)cc1	10.1016/j.bmc.2009.12.067
		19426635	205593	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptorBinding affinity for human cloned 5-hydroxytryptamine 7 receptor	ChEMBL	280	2	1	3	3.1	CNCC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		CHEMBL81485	205593	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptorBinding affinity for human cloned 5-hydroxytryptamine 7 receptor	ChEMBL	280	2	1	3	3.1	CNCC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		73351903	89695	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	360	3	2	4	3.1	Cc1[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc2c1C1=CCNCC1	10.1016/j.ejmech.2013.03.006
		CHEMBL2376484	89695	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	360	3	2	4	3.1	Cc1[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc2c1C1=CCNCC1	10.1016/j.ejmech.2013.03.006
		46232819	201154	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	493	10	0	5	4.5	COc1ccccc1N1CCN(CCCN(CC2CC2)S(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmc.2009.12.067
		CHEMBL603272	201154	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	493	10	0	5	4.5	COc1ccccc1N1CCN(CCCN(CC2CC2)S(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmc.2009.12.067
		44452166	95809	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	543	10	1	7	4.1	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
		CHEMBL258785	95809	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	543	10	1	7	4.1	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
		44452166	95809	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	543	10	1	7	4.1	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
		CHEMBL258785	95809	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	543	10	1	7	4.1	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
		44452005	95945	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	559	10	1	8	3.8	COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)cc1	10.1016/j.bmc.2007.11.049
		CHEMBL259407	95945	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	559	10	1	8	3.8	COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)cc1	10.1016/j.bmc.2007.11.049
		44451954	160375	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		CHEMBL411105	160375	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		44452005	95945	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	559	10	1	8	3.8	COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)cc1	10.1016/j.ejmech.2008.09.050
		CHEMBL259407	95945	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	559	10	1	8	3.8	COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)cc1	10.1016/j.ejmech.2008.09.050
		44451954	160375	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		CHEMBL411105	160375	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		46232559	201094	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	505	9	0	4	5.6	O=S(=O)(c1cccc2ccccc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
		CHEMBL602882	201094	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	505	9	0	4	5.6	O=S(=O)(c1cccc2ccccc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
		44452196	96029	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	509	8	1	6	4.2	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.ejmech.2008.09.050
		CHEMBL259827	96029	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	509	8	1	6	4.2	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.ejmech.2008.09.050
		44451953	96279	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.ejmech.2008.09.050
		CHEMBL261149	96279	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.ejmech.2008.09.050
		44452080	155777	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		CHEMBL405892	155777	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		44452144	96300	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	511	9	1	7	3.6	COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
		CHEMBL261232	96300	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	511	9	1	7	3.6	COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
		5	139	72	None	-3	54	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/np0205102
		5202	139	72	None	-3	54	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/np0205102
		CHEMBL39	139	72	None	-3	54	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/np0205102
		DB08839	139	72	None	-3	54	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/np0205102
		3233	3512	44	None	2	12	Human	8.6	pIC50	=	8.6	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2019.07.046
		3247	3512	44	None	2	12	Human	8.6	pIC50	=	8.6	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2019.07.046
		6604889	3512	44	None	2	12	Human	8.6	pIC50	=	8.6	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2019.07.046
		CHEMBL282199	3512	44	None	2	12	Human	8.6	pIC50	=	8.6	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2019.07.046
		DB13988	3512	44	None	2	12	Human	8.6	pIC50	=	8.6	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2019.07.046
		3233	3512	44	None	2	12	Human	8.6	pIC50	=	8.6	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2019.07.046
		3247	3512	44	None	2	12	Human	8.6	pIC50	=	8.6	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2019.07.046
		6604889	3512	44	None	2	12	Human	8.6	pIC50	=	8.6	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2019.07.046
		CHEMBL282199	3512	44	None	2	12	Human	8.6	pIC50	=	8.6	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2019.07.046
		DB13988	3512	44	None	2	12	Human	8.6	pIC50	=	8.6	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2019.07.046
		42388639	188054	0	None	-4	6	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	439	8	1	5	3.3	COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmc.2008.04.023
		CHEMBL497749	188054	0	None	-4	6	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	439	8	1	5	3.3	COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmc.2008.04.023
		44452170	166989	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	511	9	1	7	3.6	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
		CHEMBL428781	166989	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	511	9	1	7	3.6	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
		44452196	96029	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	509	8	1	6	4.2	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.bmc.2007.11.049
		CHEMBL259827	96029	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	509	8	1	6	4.2	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.bmc.2007.11.049
		44451953	96279	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.bmc.2007.11.049
		CHEMBL261149	96279	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.bmc.2007.11.049
		44452080	155777	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		CHEMBL405892	155777	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		44452144	96300	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	511	9	1	7	3.6	COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
		CHEMBL261232	96300	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	511	9	1	7	3.6	COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
		51003551	56670	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in cells	ChEMBL	449	3	0	5	3.8	CC1CC(=O)c2c(N3CCN(C)CC3)cccc2N1S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmcl.2010.12.007
		CHEMBL1642123	56670	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in cells	ChEMBL	449	3	0	5	3.8	CC1CC(=O)c2c(N3CCN(C)CC3)cccc2N1S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmcl.2010.12.007
		10907460	9828	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	521	11	1	3	5.8	CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
		CHEMBL113956	9828	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	521	11	1	3	5.8	CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
		49864292	15595	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	471	6	0	4	5.0	CN1CCN(c2cccc(N(Cc3ccccc3)S(=O)(=O)c3ccc4ccccc4c3)c2)CC1	10.1016/j.bmcl.2010.06.150
		CHEMBL1221452	15595	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	471	6	0	4	5.0	CN1CCN(c2cccc(N(Cc3ccccc3)S(=O)(=O)c3ccc4ccccc4c3)c2)CC1	10.1016/j.bmcl.2010.06.150
		49864724	15692	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	409	5	0	4	3.8	CCN(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmcl.2010.06.150
		CHEMBL1222364	15692	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	409	5	0	4	3.8	CCN(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmcl.2010.06.150
		44452274	96236	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	541	10	1	8	3.6	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.ejmech.2008.09.050
		CHEMBL260902	96236	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	541	10	1	8	3.6	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.ejmech.2008.09.050
		44452170	166989	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	511	9	1	7	3.6	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
		CHEMBL428781	166989	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	511	9	1	7	3.6	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
		44452274	96236	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	541	10	1	8	3.6	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.bmc.2007.11.049
		CHEMBL260902	96236	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	541	10	1	8	3.6	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.bmc.2007.11.049
		11730467	11028	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	476	10	0	2	6.0	O=C(CCCc1ccccc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
		CHEMBL117537	11028	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	476	10	0	2	6.0	O=C(CCCc1ccccc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
		155531753	171646	0	None	-1	2	Human	6.7	pIC50	=	6.7	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	548	11	1	7	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
		CHEMBL4465959	171646	0	None	-1	2	Human	6.7	pIC50	=	6.7	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	548	11	1	7	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
		155531753	171646	0	None	-1	2	Human	6.7	pIC50	=	6.7	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	548	11	1	7	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
		CHEMBL4465959	171646	0	None	-1	2	Human	6.7	pIC50	=	6.7	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	548	11	1	7	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
		44451929	96063	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		CHEMBL260003	96063	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		44451929	96063	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		CHEMBL260003	96063	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		42635570	187371	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	439	8	1	5	3.3	COc1cccc(N2CCN(CCCNS(=O)(=O)c3ccc4ccccc4c3)CC2)c1	10.1016/j.bmc.2008.04.023
		CHEMBL493416	187371	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	439	8	1	5	3.3	COc1cccc(N2CCN(CCCNS(=O)(=O)c3ccc4ccccc4c3)CC2)c1	10.1016/j.bmc.2008.04.023
		46232729	201456	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	574	9	0	5	6.3	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
		CHEMBL604952	201456	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	574	9	0	5	6.3	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
		44452139	96210	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	559	10	1	8	3.8	COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)c1	10.1016/j.bmc.2007.11.049
		CHEMBL260804	96210	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	559	10	1	8	3.8	COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)c1	10.1016/j.bmc.2007.11.049
		44452139	96210	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	559	10	1	8	3.8	COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)c1	10.1016/j.ejmech.2008.09.050
		CHEMBL260804	96210	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	559	10	1	8	3.8	COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)c1	10.1016/j.ejmech.2008.09.050
		44452302	96271	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		CHEMBL261100	96271	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		46232689	200959	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	536	10	0	6	5.0	COc1ccccc1N1CCN(CCCN(CC2CCCCC2)S(=O)(=O)c2cccc3cccnc23)CC1	10.1016/j.bmc.2009.12.067
		CHEMBL601885	200959	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	536	10	0	6	5.0	COc1ccccc1N1CCN(CCCN(CC2CCCCC2)S(=O)(=O)c2cccc3cccnc23)CC1	10.1016/j.bmc.2009.12.067
		44452302	96271	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		CHEMBL261100	96271	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		44451957	158496	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	515	8	1	7	3.4	COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)cc1	10.1016/j.bmc.2007.11.049
		CHEMBL409107	158496	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	515	8	1	7	3.4	COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)cc1	10.1016/j.bmc.2007.11.049
		44451957	158496	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	515	8	1	7	3.4	COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
		CHEMBL409107	158496	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	515	8	1	7	3.4	COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
		11304851	154605	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	426	4	3	8	3.7	O=[N+]([O-])c1cc(O)c2c(c1)S(=O)(=O)N=C(Nc1ccccc1Oc1ccccc1)N2	10.1016/j.bmcl.2007.05.011
		CHEMBL399203	154605	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	426	4	3	8	3.7	O=[N+]([O-])c1cc(O)c2c(c1)S(=O)(=O)N=C(Nc1ccccc1Oc1ccccc1)N2	10.1016/j.bmcl.2007.05.011
		44452143	96299	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	525	10	1	7	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
		CHEMBL261231	96299	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	525	10	1	7	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
		44452143	96299	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	525	10	1	7	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
		CHEMBL261231	96299	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	525	10	1	7	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
		44451952	160373	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.bmc.2007.11.049
		CHEMBL411104	160373	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.bmc.2007.11.049
		44451952	160373	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.ejmech.2008.09.050
		CHEMBL411104	160373	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.ejmech.2008.09.050
		44452006	157501	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	567	8	1	6	5.1	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		CHEMBL407966	157501	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	567	8	1	6	5.1	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		44452006	157501	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	567	8	1	6	5.1	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		CHEMBL407966	157501	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	567	8	1	6	5.1	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		44452037	96197	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.ejmech.2008.09.050
		CHEMBL260756	96197	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.ejmech.2008.09.050
		44452273	158137	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.ejmech.2008.09.050
		CHEMBL408717	158137	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.ejmech.2008.09.050
		46866711	15670	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	423	5	0	4	4.2	CC(C)N(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1cccc2ccccc12	10.1016/j.bmcl.2010.06.150
		CHEMBL1222234	15670	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	423	5	0	4	4.2	CC(C)N(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1cccc2ccccc12	10.1016/j.bmcl.2010.06.150
		42388975	192721	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	407	8	1	5	2.3	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3F)CC2)cc1	10.1016/j.bmc.2008.04.023
		CHEMBL522006	192721	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	407	8	1	5	2.3	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3F)CC2)cc1	10.1016/j.bmc.2008.04.023
		44452037	96197	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.bmc.2007.11.049
		CHEMBL260756	96197	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.bmc.2007.11.049
		44452273	158137	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.bmc.2007.11.049
		CHEMBL408717	158137	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.bmc.2007.11.049
		4106	2502	22	None	-4	34	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmc.2007.11.049
		5358812	2502	22	None	-4	34	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmc.2007.11.049
		89	2502	22	None	-4	34	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmc.2007.11.049
		CHEMBL93240	2502	22	None	-4	34	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmc.2007.11.049
		4223	3992	94	None	-	3	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1021/jm040793q
		6918314	3992	94	None	-	3	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1021/jm040793q
		7427	3992	94	None	-	3	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1021/jm040793q
		CHEMBL439849	3992	94	None	-	3	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1021/jm040793q
		DB06684	3992	94	None	-	3	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1021/jm040793q
		10131112	1552	25	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human	ChEMBL	246	1	2	1	3.5	Clc1ccc2c(c1)c(C1=CCNCC1)c([nH]2)C	10.1016/j.bmcl.2005.06.067
		8428	1552	25	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human	ChEMBL	246	1	2	1	3.5	Clc1ccc2c(c1)c(C1=CCNCC1)c([nH]2)C	10.1016/j.bmcl.2005.06.067
		CHEMBL364005	1552	25	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human	ChEMBL	246	1	2	1	3.5	Clc1ccc2c(c1)c(C1=CCNCC1)c([nH]2)C	10.1016/j.bmcl.2005.06.067
		49864289	15592	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	435	6	0	4	4.2	CN1CCN(c2cccc(N(CC3CC3)S(=O)(=O)c3ccc4ccccc4c3)c2)CC1	10.1016/j.bmcl.2010.06.150
		CHEMBL1221449	15592	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	435	6	0	4	4.2	CN1CCN(c2cccc(N(CC3CC3)S(=O)(=O)c3ccc4ccccc4c3)c2)CC1	10.1016/j.bmcl.2010.06.150
		73347306	89694	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	230	1	2	1	3.0	Cc1[nH]c2ccc(F)cc2c1C1=CCNCC1	10.1016/j.ejmech.2013.03.006
		CHEMBL2376483	89694	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	230	1	2	1	3.0	Cc1[nH]c2ccc(F)cc2c1C1=CCNCC1	10.1016/j.ejmech.2013.03.006
		46232772	200857	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	473	11	0	6	3.3	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3OC)CC2)CC2CC2)cc1	10.1016/j.bmc.2009.12.067
		CHEMBL601250	200857	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	473	11	0	6	3.3	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3OC)CC2)CC2CC2)cc1	10.1016/j.bmc.2009.12.067
		46232977	201196	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	453	8	1	5	3.7	COc1ccccc1N1CCN(CCC(C)NS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmc.2009.12.067
		CHEMBL603499	201196	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	453	8	1	5	3.7	COc1ccccc1N1CCN(CCC(C)NS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmc.2009.12.067
		42389293	187534	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	439	8	1	5	3.3	COc1ccc(N2CCN(CCCNS(=O)(=O)c3ccc4ccccc4c3)CC2)cc1	10.1016/j.bmc.2008.04.023
		CHEMBL494427	187534	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	439	8	1	5	3.3	COc1ccc(N2CCN(CCCNS(=O)(=O)c3ccc4ccccc4c3)CC2)cc1	10.1016/j.bmc.2008.04.023
		45278805	7450	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	484	7	1	4	5.2	Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1C	10.1016/j.bmcl.2010.01.093
		CHEMBL1086754	7450	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	484	7	1	4	5.2	Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1C	10.1016/j.bmcl.2010.01.093
		46232731	200892	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	481	9	0	4	4.3	O=S(=O)(c1ccc(C(F)(F)F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
		CHEMBL601458	200892	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	481	9	0	4	4.3	O=S(=O)(c1ccc(C(F)(F)F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
		42635029	187433	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	419	9	1	6	2.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3cccc(OC)c3)CC2)cc1	10.1016/j.bmc.2008.04.023
		CHEMBL493810	187433	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	419	9	1	6	2.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3cccc(OC)c3)CC2)cc1	10.1016/j.bmc.2008.04.023
		46232820	200852	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	531	9	0	4	5.5	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
		CHEMBL601220	200852	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	531	9	0	4	5.5	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
		44452357	95906	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
		CHEMBL259236	95906	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
		44452118	96353	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	549	8	1	6	4.6	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		CHEMBL261573	96353	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	549	8	1	6	4.6	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		46232975	201097	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	482	9	0	5	4.0	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
		CHEMBL602889	201097	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	482	9	0	5	4.0	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
		44452357	95906	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
		CHEMBL259236	95906	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
		44452118	96353	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	549	8	1	6	4.6	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		CHEMBL261573	96353	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	549	8	1	6	4.6	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		46232978	201119	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	491	7	1	4	4.7	CC(CCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NS(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmc.2009.12.067
		CHEMBL603093	201119	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	491	7	1	4	4.7	CC(CCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NS(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmc.2009.12.067
		44451931	95764	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	501	7	1	6	3.9	O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		CHEMBL258525	95764	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	501	7	1	6	3.9	O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		11166042	166369	0	None	2	3	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	419	9	1	6	2.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2008.04.023
		CHEMBL427518	166369	0	None	2	3	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	419	9	1	6	2.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2008.04.023
		44451931	95764	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	501	7	1	6	3.9	O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		CHEMBL258525	95764	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	501	7	1	6	3.9	O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		73351905	89702	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	288	2	2	1	4.5	Cc1[nH]c2ccc(-c3ccccc3)cc2c1C1=CCNCC1	10.1016/j.ejmech.2013.03.006
		CHEMBL2376491	89702	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	288	2	2	1	4.5	Cc1[nH]c2ccc(-c3ccccc3)cc2c1C1=CCNCC1	10.1016/j.ejmech.2013.03.006
		42635571	187760	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	421	8	1	5	2.7	COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3ccc(F)cc3)CC2)cc1	10.1016/j.bmc.2008.04.023
		CHEMBL495685	187760	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	421	8	1	5	2.7	COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3ccc(F)cc3)CC2)cc1	10.1016/j.bmc.2008.04.023
		42635572	187797	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	403	8	1	5	2.6	COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3ccccc3)CC2)cc1	10.1016/j.bmc.2008.04.023
		CHEMBL495890	187797	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	403	8	1	5	2.6	COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3ccccc3)CC2)cc1	10.1016/j.bmc.2008.04.023
		42635028	193215	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	457	8	1	5	3.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccc(C(F)(F)F)cc3)CC2)cc1	10.1016/j.bmc.2008.04.023
		CHEMBL523519	193215	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	457	8	1	5	3.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccc(C(F)(F)F)cc3)CC2)cc1	10.1016/j.bmc.2008.04.023
		49864723	15691	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	423	6	0	4	4.2	CCCN(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmcl.2010.06.150
		CHEMBL1222363	15691	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	423	6	0	4	4.2	CCCN(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmcl.2010.06.150
		44452329	158738	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		CHEMBL409358	158738	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		44452329	158738	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		CHEMBL409358	158738	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		45278882	7452	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	512	9	1	4	6.1	CCCn1c(-c2ccccc2)cc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1C	10.1016/j.bmcl.2010.01.093
		CHEMBL1086756	7452	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	512	9	1	4	6.1	CCCn1c(-c2ccccc2)cc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1C	10.1016/j.bmcl.2010.01.093
		46232654	201020	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	506	9	0	5	5.0	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
		CHEMBL602285	201020	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	506	9	0	5	5.0	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
		44452197	96073	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	509	8	1	6	4.2	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.ejmech.2008.09.050
		CHEMBL260029	96073	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	509	8	1	6	4.2	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.ejmech.2008.09.050
		44452081	96176	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		CHEMBL260648	96176	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		44452008	95946	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		CHEMBL259408	95946	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		44452197	96073	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	509	8	1	6	4.2	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.bmc.2007.11.049
		CHEMBL260029	96073	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	509	8	1	6	4.2	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.bmc.2007.11.049
		44452081	96176	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		CHEMBL260648	96176	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		44452171	168697	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	511	9	1	7	3.6	CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
		CHEMBL436700	168697	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	511	9	1	7	3.6	CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
		46232691	200961	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	524	9	0	5	5.2	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
		CHEMBL601887	200961	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	524	9	0	5	5.2	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
		11761059	10051	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	394	4	1	8	3.1	O=[N+]([O-])c1cc2c(cc1CN1CC=C(n3c(O)nc4ccccc43)CC1)OCO2	10.1021/jm010878g
		CHEMBL115229	10051	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	394	4	1	8	3.1	O=[N+]([O-])c1cc2c(cc1CN1CC=C(n3c(O)nc4ccccc43)CC1)OCO2	10.1021/jm010878g
		49864722	15690	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	395	4	0	4	3.4	CN1CCN(c2cccc(N(C)S(=O)(=O)c3ccc4ccccc4c3)c2)CC1	10.1016/j.bmcl.2010.06.150
		CHEMBL1222362	15690	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	395	4	0	4	3.4	CN1CCN(c2cccc(N(C)S(=O)(=O)c3ccc4ccccc4c3)c2)CC1	10.1016/j.bmcl.2010.06.150
		44452328	96081	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	567	8	1	6	5.1	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		CHEMBL260076	96081	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	567	8	1	6	5.1	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		44452249	158550	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		CHEMBL409157	158550	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		44452171	168697	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	511	9	1	7	3.6	CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
		CHEMBL436700	168697	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	511	9	1	7	3.6	CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
		44452328	96081	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	567	8	1	6	5.1	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		CHEMBL260076	96081	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	567	8	1	6	5.1	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		44452249	158550	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		CHEMBL409157	158550	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		46232560	201017	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	523	9	0	4	5.5	O=S(=O)(c1ccc(C(F)(F)F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
		CHEMBL602274	201017	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	523	9	0	4	5.5	O=S(=O)(c1ccc(C(F)(F)F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
		45109862	7434	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	470	7	2	3	5.2	Cc1[nH]c(-c2ccccc2)cc1C(=O)NCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2010.01.093
		CHEMBL1086626	7434	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	470	7	2	3	5.2	Cc1[nH]c(-c2ccccc2)cc1C(=O)NCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2010.01.093
		44452222	95949	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	509	8	1	6	4.2	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.bmc.2007.11.049
		CHEMBL259415	95949	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	509	8	1	6	4.2	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.bmc.2007.11.049
		44452222	95949	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	509	8	1	6	4.2	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.ejmech.2008.09.050
		CHEMBL259415	95949	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	509	8	1	6	4.2	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.ejmech.2008.09.050
		44452117	96352	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		CHEMBL261572	96352	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		42389467	187436	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	407	8	1	5	2.3	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccc(F)cc3)CC2)cc1	10.1016/j.bmc.2008.04.023
		CHEMBL493816	187436	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	407	8	1	5	2.3	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccc(F)cc3)CC2)cc1	10.1016/j.bmc.2008.04.023
		44452217	95853	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.ejmech.2008.09.050
		CHEMBL259001	95853	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.ejmech.2008.09.050
		44452117	96352	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		CHEMBL261572	96352	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		36418162	187562	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	423	8	1	4	3.3	O=S(=O)(NCCCN1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
		CHEMBL494573	187562	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	423	8	1	4	3.3	O=S(=O)(NCCCN1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
		637308	183908	37	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	314	6	2	5	2.9	COc1cc(/C=C/C(=O)OCCc2ccc(O)cc2)ccc1O	10.1021/np050301s
		CHEMBL481245	183908	37	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	314	6	2	5	2.9	COc1cc(/C=C/C(=O)OCCc2ccc(O)cc2)ccc1O	10.1021/np050301s
		10337743	4076	18	None	-	1	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells	ChEMBL	347	5	0	5	2.6	CN(CCn1cc(c2c1nccc2)S(=O)(=O)c1cccc(c1)F)C	10.1016/j.bmc.2009.05.055
		8429	4076	18	None	-	1	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells	ChEMBL	347	5	0	5	2.6	CN(CCn1cc(c2c1nccc2)S(=O)(=O)c1cccc(c1)F)C	10.1016/j.bmc.2009.05.055
		CHEMBL571858	4076	18	None	-	1	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells	ChEMBL	347	5	0	5	2.6	CN(CCn1cc(c2c1nccc2)S(=O)(=O)c1cccc(c1)F)C	10.1016/j.bmc.2009.05.055
		44452217	95853	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.bmc.2007.11.049
		CHEMBL259001	95853	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.bmc.2007.11.049
		44452007	95898	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.ejmech.2008.09.050
		CHEMBL259199	95898	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.ejmech.2008.09.050
		73354882	89693	1	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	290	1	2	1	3.6	Cc1[nH]c2ccc(Br)cc2c1C1=CCNCC1	10.1016/j.ejmech.2013.03.006
		CHEMBL2376482	89693	1	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	290	1	2	1	3.6	Cc1[nH]c2ccc(Br)cc2c1C1=CCNCC1	10.1016/j.ejmech.2013.03.006
		44452007	95898	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.bmc.2007.11.049
		CHEMBL259199	95898	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.bmc.2007.11.049
		46232858	200783	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	481	9	0	4	4.6	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
		CHEMBL600606	200783	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	481	9	0	4	4.6	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
		45278883	7649	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	553	8	1	5	5.8	Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1N1CCCCC1	10.1016/j.bmcl.2010.01.093
		CHEMBL1088313	7649	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	553	8	1	5	5.8	Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1N1CCCCC1	10.1016/j.bmcl.2010.01.093
		72197668	102495	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	360	5	2	5	3.5	COc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
		CHEMBL2393246	102495	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	360	5	2	5	3.5	COc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
		CHEMBL3040325	102495	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	360	5	2	5	3.5	COc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
		44451959	96280	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	513	7	1	6	4.0	Cc1cccc(C)c1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1	10.1016/j.bmc.2007.11.049
		CHEMBL261151	96280	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	513	7	1	6	4.0	Cc1cccc(C)c1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1	10.1016/j.bmc.2007.11.049
		44451984	96364	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	513	7	1	6	4.0	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)c(C)c1	10.1016/j.bmc.2007.11.049
		CHEMBL261653	96364	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	513	7	1	6	4.0	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)c(C)c1	10.1016/j.bmc.2007.11.049
		46232623	200739	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	535	10	0	5	5.6	COc1ccccc1N1CCN(CCCN(CC2CCCCC2)S(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmc.2009.12.067
		CHEMBL600210	200739	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	535	10	0	5	5.6	COc1ccccc1N1CCN(CCCN(CC2CCCCC2)S(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmc.2009.12.067
		46232770	200841	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	458	10	0	6	3.2	O=[N+]([O-])c1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CC2)cc1	10.1016/j.bmc.2009.12.067
		CHEMBL601037	200841	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	458	10	0	6	3.2	O=[N+]([O-])c1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CC2)cc1	10.1016/j.bmc.2009.12.067
		44451959	96280	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	513	7	1	6	4.0	Cc1cccc(C)c1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1	10.1016/j.ejmech.2008.09.050
		CHEMBL261151	96280	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	513	7	1	6	4.0	Cc1cccc(C)c1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1	10.1016/j.ejmech.2008.09.050
		44451984	96364	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	513	7	1	6	4.0	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)c(C)c1	10.1016/j.ejmech.2008.09.050
		CHEMBL261653	96364	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	513	7	1	6	4.0	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)c(C)c1	10.1016/j.ejmech.2008.09.050
		44451986	159364	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	501	7	1	6	3.9	O=C(CCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		CHEMBL410042	159364	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	501	7	1	6	3.9	O=C(CCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		44451986	159364	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	501	7	1	6	3.9	O=C(CCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		CHEMBL410042	159364	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	501	7	1	6	3.9	O=C(CCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		10407367	196793	0	None	-	1	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells	ChEMBL	379	5	0	5	3.6	CN(C)CCn1cc(S(=O)(=O)c2cccc3ccccc23)c2cccnc21	10.1016/j.bmc.2009.05.055
		CHEMBL565552	196793	0	None	-	1	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells	ChEMBL	379	5	0	5	3.6	CN(C)CCn1cc(S(=O)(=O)c2cccc3ccccc23)c2cccnc21	10.1016/j.bmc.2009.05.055
		44452008	95946	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		CHEMBL259408	95946	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		45278886	7650	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	564	8	1	4	6.8	Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1-c1ccc(F)cc1	10.1016/j.bmcl.2010.01.093
		CHEMBL1088314	7650	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	564	8	1	4	6.8	Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1-c1ccc(F)cc1	10.1016/j.bmcl.2010.01.093
		46233014	201018	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	441	7	1	4	3.9	CC(CCN1CCN(c2ccc(F)cc2)CC1)NS(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmc.2009.12.067
		CHEMBL602279	201018	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	441	7	1	4	3.9	CC(CCN1CCN(c2ccc(F)cc2)CC1)NS(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmc.2009.12.067
		42389457	187733	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	427	7	1	4	3.5	O=S(=O)(NCCCN1CCN(c2ccc(F)cc2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
		CHEMBL495445	187733	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	427	7	1	4	3.5	O=S(=O)(NCCCN1CCN(c2ccc(F)cc2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
		44452193	96070	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.ejmech.2008.09.050
		CHEMBL260022	96070	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.ejmech.2008.09.050
		44451982	96325	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.ejmech.2008.09.050
		CHEMBL261434	96325	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.ejmech.2008.09.050
		16	2253	8	None	-	1	Rat	6.3	pIC50	=	6.3	Binding	Compound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 7 receptor stably expressed in CHO cellsCompound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 7 receptor stably expressed in CHO cells	ChEMBL	462	9	3	6	3.6	OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm9910021
		9847194	2253	8	None	-	1	Rat	6.3	pIC50	=	6.3	Binding	Compound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 7 receptor stably expressed in CHO cellsCompound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 7 receptor stably expressed in CHO cells	ChEMBL	462	9	3	6	3.6	OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm9910021
		CHEMBL313714	2253	8	None	-	1	Rat	6.3	pIC50	=	6.3	Binding	Compound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 7 receptor stably expressed in CHO cellsCompound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 7 receptor stably expressed in CHO cells	ChEMBL	462	9	3	6	3.6	OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm9910021
		44452193	96070	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.bmc.2007.11.049
		CHEMBL260022	96070	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.bmc.2007.11.049
		44451982	96325	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.bmc.2007.11.049
		CHEMBL261434	96325	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.bmc.2007.11.049
		46700867	175990	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 60 minsDisplacement of [3H]LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 60 mins	ChEMBL	377	14	1	4	5.0	CCCCCCCCCCNC(=O)/C=C/c1cc(OC)c(OC)c(OC)c1	10.1016/j.ejmech.2019.04.009
		CHEMBL4588956	175990	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 60 minsDisplacement of [3H]LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 60 mins	ChEMBL	377	14	1	4	5.0	CCCCCCCCCCNC(=O)/C=C/c1cc(OC)c(OC)c(OC)c1	10.1016/j.ejmech.2019.04.009
		42635205	187795	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	477	7	1	4	4.3	O=S(=O)(NCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
		CHEMBL495884	187795	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	477	7	1	4	4.3	O=S(=O)(NCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
		46232588	200957	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	485	10	0	5	4.5	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CCCCC2)cc1	10.1016/j.bmc.2009.12.067
		CHEMBL601872	200957	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	485	10	0	5	4.5	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CCCCC2)cc1	10.1016/j.bmc.2009.12.067
		42635389	187369	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	433	9	1	6	2.6	COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2008.04.023
		CHEMBL493402	187369	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	433	9	1	6	2.6	COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2008.04.023
		44452275	96237	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.bmc.2007.11.049
		CHEMBL260903	96237	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.bmc.2007.11.049
		44452298	96312	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	541	9	1	7	3.9	CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
		CHEMBL261337	96312	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	541	9	1	7	3.9	CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
		44452275	96237	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.ejmech.2008.09.050
		CHEMBL260903	96237	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.ejmech.2008.09.050
		44452298	96312	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	541	9	1	7	3.9	CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
		CHEMBL261337	96312	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	541	9	1	7	3.9	CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
		46232861	201093	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	532	9	0	5	4.9	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
		CHEMBL602878	201093	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	532	9	0	5	4.9	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
		54577891	66575	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of 5HT7 receptor by competition binding assayInhibition of 5HT7 receptor by competition binding assay	ChEMBL	471	6	1	5	4.3	Cc1nc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1	10.1021/jm200682b
		CHEMBL1852516	66575	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of 5HT7 receptor by competition binding assayInhibition of 5HT7 receptor by competition binding assay	ChEMBL	471	6	1	5	4.3	Cc1nc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1	10.1021/jm200682b
		CHEMBL3216758	66575	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of 5HT7 receptor by competition binding assayInhibition of 5HT7 receptor by competition binding assay	ChEMBL	471	6	1	5	4.3	Cc1nc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1	10.1021/jm200682b
		44451979	96324	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.ejmech.2008.09.050
		CHEMBL261433	96324	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.ejmech.2008.09.050
		72198754	90880	0	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human 5-HT7 receptorInhibition of human 5-HT7 receptor	ChEMBL	443	8	0	4	4.8	COc1ccccc1N1CCN(CCCCCN2Cc3ccc4ccccc4c3C2=O)CC1	10.1016/j.ejmech.2013.01.044
		CHEMBL2392349	90880	0	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human 5-HT7 receptorInhibition of human 5-HT7 receptor	ChEMBL	443	8	0	4	4.8	COc1ccccc1N1CCN(CCCCCN2Cc3ccc4ccccc4c3C2=O)CC1	10.1016/j.ejmech.2013.01.044
		53320010	56664	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in cells	ChEMBL	435	3	0	5	3.4	CN1CCN(c2cccc3c2C(=O)CCN3S(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.12.007
		CHEMBL1642117	56664	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in cells	ChEMBL	435	3	0	5	3.4	CN1CCN(c2cccc3c2C(=O)CCN3S(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.12.007
		44451979	96324	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.bmc.2007.11.049
		CHEMBL261433	96324	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.bmc.2007.11.049
		185617	186554	86	None	-	0	Human	4.2	pIC50	=	4.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	462	4	7	11	-0.2	O=C(O)[C@H]1O[C@@H](Oc2cc3oc(-c4ccc(O)cc4)cc(=O)c3c(O)c2O)[C@H](O)[C@@H](O)[C@@H]1O	10.1021/np0205102
		CHEMBL487805	186554	86	None	-	0	Human	4.2	pIC50	=	4.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	462	4	7	11	-0.2	O=C(O)[C@H]1O[C@@H](Oc2cc3oc(-c4ccc(O)cc4)cc(=O)c3c(O)c2O)[C@H](O)[C@@H](O)[C@@H]1O	10.1021/np0205102
		44452279	161288	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	495	7	1	6	3.8	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.ejmech.2008.09.050
		CHEMBL412153	161288	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	495	7	1	6	3.8	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.ejmech.2008.09.050
		44452279	161288	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	495	7	1	6	3.8	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.bmc.2007.11.049
		CHEMBL412153	161288	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	495	7	1	6	3.8	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.bmc.2007.11.049
		44452331	96107	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	481	8	1	6	3.6	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		CHEMBL260249	96107	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	481	8	1	6	3.6	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		44452331	96107	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	481	8	1	6	3.6	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		CHEMBL260249	96107	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	481	8	1	6	3.6	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		46232976	201118	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	423	7	1	4	3.7	CC(CCN1CCN(c2ccccc2)CC1)NS(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmc.2009.12.067
		CHEMBL603092	201118	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	423	7	1	4	3.7	CC(CCN1CCN(c2ccccc2)CC1)NS(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmc.2009.12.067
		10949380	164023	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	399	3	1	6	4.3	Cc1ccc2nc(O)n(C3CCN(Cc4cc5c(cc4Cl)OCO5)CC3)c2c1	10.1021/jm010878g
		CHEMBL420863	164023	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	399	3	1	6	4.3	Cc1ccc2nc(O)n(C3CCN(Cc4cc5c(cc4Cl)OCO5)CC3)c2c1	10.1021/jm010878g
		46232620	200836	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	553	10	0	5	5.5	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC2CCCCC2)cc1	10.1016/j.bmc.2009.12.067
		CHEMBL601022	200836	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	553	10	0	5	5.5	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC2CCCCC2)cc1	10.1016/j.bmc.2009.12.067
		44452010	95990	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	485	7	1	6	3.4	O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1	10.1016/j.bmc.2007.11.049
		CHEMBL259619	95990	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	485	7	1	6	3.4	O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1	10.1016/j.bmc.2007.11.049
		44452141	96252	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	541	9	1	7	3.9	CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
		CHEMBL261018	96252	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	541	9	1	7	3.9	CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
		44452010	95990	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	485	7	1	6	3.4	O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1	10.1016/j.ejmech.2008.09.050
		CHEMBL259619	95990	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	485	7	1	6	3.4	O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1	10.1016/j.ejmech.2008.09.050
		44452141	96252	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	541	9	1	7	3.9	CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
		CHEMBL261018	96252	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	541	9	1	7	3.9	CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
		42389129	193111	2	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	409	7	1	4	3.3	O=S(=O)(NCCCN1CCN(c2ccccc2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
		CHEMBL522694	193111	2	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	409	7	1	4	3.3	O=S(=O)(NCCCN1CCN(c2ccccc2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
		73356443	89701	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	294	2	2	2	4.6	Cc1[nH]c2ccc(-c3ccsc3)cc2c1C1=CCNCC1	10.1016/j.ejmech.2013.03.006
		CHEMBL2376490	89701	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	294	2	2	2	4.6	Cc1[nH]c2ccc(-c3ccsc3)cc2c1C1=CCNCC1	10.1016/j.ejmech.2013.03.006
		44452221	95948	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	509	8	1	6	4.2	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.bmc.2007.11.049
		CHEMBL259414	95948	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	509	8	1	6	4.2	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.bmc.2007.11.049
		44452221	95948	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	509	8	1	6	4.2	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.ejmech.2008.09.050
		CHEMBL259414	95948	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	509	8	1	6	4.2	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.ejmech.2008.09.050
		44452199	96071	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	497	8	1	7	3.2	COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
		CHEMBL260023	96071	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	497	8	1	7	3.2	COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
		44452199	96071	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	497	8	1	7	3.2	COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
		CHEMBL260023	96071	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	497	8	1	7	3.2	COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
		11071079	110593	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	496	9	0	3	6.0	O=C(OCCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
		CHEMBL325516	110593	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	496	9	0	3	6.0	O=C(OCCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
		44452332	96108	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	481	7	1	6	3.5	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
		CHEMBL260250	96108	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	481	7	1	6	3.5	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
		44452362	96509	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	530	8	1	8	3.3	O=C(CCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1	10.1016/j.ejmech.2008.09.050
		CHEMBL262589	96509	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	530	8	1	8	3.3	O=C(CCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1	10.1016/j.ejmech.2008.09.050
		44452324	96238	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	567	8	1	6	4.8	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		CHEMBL260906	96238	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	567	8	1	6	4.8	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		44452332	96108	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	481	7	1	6	3.5	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
		CHEMBL260250	96108	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	481	7	1	6	3.5	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
		44452362	96509	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	530	8	1	8	3.3	O=C(CCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1	10.1016/j.bmc.2007.11.049
		CHEMBL262589	96509	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	530	8	1	8	3.3	O=C(CCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1	10.1016/j.bmc.2007.11.049
		44452324	96238	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	567	8	1	6	4.8	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		CHEMBL260906	96238	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	567	8	1	6	4.8	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		44452327	96272	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.ejmech.2008.09.050
		CHEMBL261102	96272	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.ejmech.2008.09.050
		46232859	200784	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	464	9	0	5	3.8	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
		CHEMBL600607	200784	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	464	9	0	5	3.8	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
		44452327	96272	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.bmc.2007.11.049
		CHEMBL261102	96272	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.bmc.2007.11.049
		10937901	9910	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	385	3	1	6	4.0	Oc1nc2ccccc2n1C1CCN(Cc2cc3c(cc2Cl)OCO3)CC1	10.1021/jm010878g
		CHEMBL114379	9910	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	385	3	1	6	4.0	Oc1nc2ccccc2n1C1CCN(Cc2cc3c(cc2Cl)OCO3)CC1	10.1021/jm010878g
		44452040	96243	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		CHEMBL260971	96243	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		44452041	96287	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		CHEMBL261187	96287	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		44452040	96243	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		CHEMBL260971	96243	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		44452041	96287	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		CHEMBL261187	96287	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		44452243	158548	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	559	10	1	8	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.bmc.2007.11.049
		CHEMBL409156	158548	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	559	10	1	8	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.bmc.2007.11.049
		44452243	158548	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	559	10	1	8	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.ejmech.2008.09.050
		CHEMBL409156	158548	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	559	10	1	8	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.ejmech.2008.09.050
		44452224	95992	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	497	8	1	7	3.2	COc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
		CHEMBL259626	95992	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	497	8	1	7	3.2	COc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
		44452224	95992	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	497	8	1	7	3.2	COc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
		CHEMBL259626	95992	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	497	8	1	7	3.2	COc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
		44452246	96186	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
		CHEMBL260705	96186	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
		44342270	9930	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	355	3	1	4	4.5	Cc1ccc(CN2CCC(n3c(O)nc4ccccc43)CC2)c(Cl)c1	10.1021/jm010878g
		CHEMBL114484	9930	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	355	3	1	4	4.5	Cc1ccc(CN2CCC(n3c(O)nc4ccccc43)CC2)c(Cl)c1	10.1021/jm010878g
		44452246	96186	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
		CHEMBL260705	96186	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
		46232587	201584	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	500	10	0	6	4.4	O=[N+]([O-])c1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CCCCC2)cc1	10.1016/j.bmc.2009.12.067
		CHEMBL605582	201584	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	500	10	0	6	4.4	O=[N+]([O-])c1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CCCCC2)cc1	10.1016/j.bmc.2009.12.067
		46232652	200990	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	573	9	0	4	6.6	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
		CHEMBL602087	200990	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	573	9	0	4	6.6	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
		42635027	187397	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	457	8	1	5	3.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)cc1	10.1016/j.bmc.2008.04.023
		CHEMBL493625	187397	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	457	8	1	5	3.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)cc1	10.1016/j.bmc.2008.04.023
		44452042	160164	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	509	8	1	7	3.4	CC(=O)c1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
		CHEMBL410922	160164	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	509	8	1	7	3.4	CC(=O)c1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
		44452167	95850	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.ejmech.2008.09.050
		CHEMBL258995	95850	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.ejmech.2008.09.050
		44452042	160164	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	509	8	1	7	3.4	CC(=O)c1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
		CHEMBL410922	160164	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	509	8	1	7	3.4	CC(=O)c1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
		44452167	95850	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.bmc.2007.11.049
		CHEMBL258995	95850	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.bmc.2007.11.049
		44452142	96253	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	567	8	1	6	4.8	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		CHEMBL261019	96253	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	567	8	1	6	4.8	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		44452142	96253	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	567	8	1	6	4.8	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		CHEMBL261019	96253	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	567	8	1	6	4.8	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		44452359	159366	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	COc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.bmc.2007.11.049
		CHEMBL410043	159366	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	COc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.bmc.2007.11.049
		44452359	159366	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	COc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.ejmech.2008.09.050
		CHEMBL410043	159366	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	COc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.ejmech.2008.09.050
		44452082	159400	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		CHEMBL410075	159400	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		46232817	200955	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	461	10	0	5	3.4	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccc(F)cc3)CC2)CC2CC2)cc1	10.1016/j.bmc.2009.12.067
		CHEMBL601859	200955	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	461	10	0	5	3.4	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccc(F)cc3)CC2)CC2CC2)cc1	10.1016/j.bmc.2009.12.067
		44452082	159400	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		CHEMBL410075	159400	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		42389303	187434	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	419	9	1	6	2.2	COc1ccc(N2CCN(CCCNS(=O)(=O)c3ccc(OC)cc3)CC2)cc1	10.1016/j.bmc.2008.04.023
		CHEMBL493811	187434	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	419	9	1	6	2.2	COc1ccc(N2CCN(CCCNS(=O)(=O)c3ccc(OC)cc3)CC2)cc1	10.1016/j.bmc.2008.04.023
		44452301	96270	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.ejmech.2008.09.050
		CHEMBL261099	96270	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.ejmech.2008.09.050
		44451985	96365	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	467	7	1	6	3.2	O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		CHEMBL261654	96365	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	467	7	1	6	3.2	O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
		44452301	96270	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.bmc.2007.11.049
		CHEMBL261099	96270	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.bmc.2007.11.049
		44451985	96365	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	467	7	1	6	3.2	O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		CHEMBL261654	96365	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	467	7	1	6	3.2	O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
		14748689	187273	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	373	8	1	4	2.2	O=S(=O)(NCCCN1CCN(Cc2ccccc2)CC1)c1ccccc1	10.1016/j.bmc.2008.04.023
		CHEMBL492794	187273	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	373	8	1	4	2.2	O=S(=O)(NCCCN1CCN(Cc2ccccc2)CC1)c1ccccc1	10.1016/j.bmc.2008.04.023
		44452305	96309	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	495	7	1	6	3.8	Cc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.bmc.2007.11.049
		CHEMBL261291	96309	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	495	7	1	6	3.8	Cc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.bmc.2007.11.049
		44452305	96309	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	495	7	1	6	3.8	Cc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.ejmech.2008.09.050
		CHEMBL261291	96309	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	495	7	1	6	3.8	Cc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.ejmech.2008.09.050
		44452078	95839	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	541	10	1	8	3.6	COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)cc1	10.1016/j.bmc.2007.11.049
		CHEMBL258956	95839	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	541	10	1	8	3.6	COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)cc1	10.1016/j.bmc.2007.11.049
		44452078	95839	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	541	10	1	8	3.6	COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)cc1	10.1016/j.ejmech.2008.09.050
		CHEMBL258956	95839	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	541	10	1	8	3.6	COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)cc1	10.1016/j.ejmech.2008.09.050
		44452195	157067	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	541	10	1	8	3.6	COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)c1	10.1016/j.ejmech.2008.09.050
		CHEMBL407411	157067	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	541	10	1	8	3.6	COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)c1	10.1016/j.ejmech.2008.09.050
		44452195	157067	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	541	10	1	8	3.6	COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)c1	10.1016/j.bmc.2007.11.049
		CHEMBL407411	157067	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	541	10	1	8	3.6	COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)c1	10.1016/j.bmc.2007.11.049
		46232621	201612	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	503	10	0	5	4.6	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccc(F)cc3)CC2)CC2CCCCC2)cc1	10.1016/j.bmc.2009.12.067
		CHEMBL605787	201612	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	503	10	0	5	4.6	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccc(F)cc3)CC2)CC2CCCCC2)cc1	10.1016/j.bmc.2009.12.067
		3066250	70286	2	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human	ChEMBL	242	2	2	2	2.9	COc1ccc2[nH]c(C)c(C3=CCNCC3)c2c1	10.1016/j.bmcl.2005.06.067
		CHEMBL194305	70286	2	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human	ChEMBL	242	2	2	2	2.9	COc1ccc2[nH]c(C)c(C3=CCNCC3)c2c1	10.1016/j.bmcl.2005.06.067
		11005810	10466	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	517	10	1	4	6.2	N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
		CHEMBL116463	10466	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	517	10	1	4	6.2	N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
		71061887	93118	0	None	66	2	Human	8.9	pKd	=	8.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins by Scatchard plot analysisDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins by Scatchard plot analysis	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccncc3)CC2)cc1	10.1016/j.bmc.2014.01.016
		CHEMBL2442996	93118	0	None	66	2	Human	8.9	pKd	=	8.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins by Scatchard plot analysisDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins by Scatchard plot analysis	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccncc3)CC2)cc1	10.1016/j.bmc.2014.01.016
		11785183	84713	0	None	-1	4	Human	7.8	pKd	=	7.8	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	419	8	1	3	4.9	Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
		CHEMBL222755	84713	0	None	-1	4	Human	7.8	pKd	=	7.8	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	419	8	1	3	4.9	Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
		11224758	2353	5	None	-4	6	Human	7.7	pKd	=	7.7	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/jm049702f
		8435	2353	5	None	-4	6	Human	7.7	pKd	=	7.7	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/jm049702f
		CHEMBL225284	2353	5	None	-4	6	Human	7.7	pKd	=	7.7	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/jm049702f
		11282296	143315	0	None	-6	4	Human	7.6	pKd	=	7.6	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	447	9	1	4	4.8	CC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
		CHEMBL389718	143315	0	None	-6	4	Human	7.6	pKd	=	7.6	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	447	9	1	4	4.8	CC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
		5	139	72	None	-3	54	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.08.023
		5202	139	72	None	-3	54	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.08.023
		CHEMBL39	139	72	None	-3	54	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.08.023
		DB08839	139	72	None	-3	54	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.08.023
		1809	134	32	None	-7	36	Human	7.5	pKd	=	7.5	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm049702f
		4	134	32	None	-7	36	Human	7.5	pKd	=	7.5	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm049702f
		CHEMBL18840	134	32	None	-7	36	Human	7.5	pKd	=	7.5	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm049702f
		11191128	85210	0	None	-5	4	Human	7.2	pKd	=	7.2	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	421	8	2	4	4.3	O=C(CCCCCN1CCN(c2ccccc2O)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
		CHEMBL225512	85210	0	None	-5	4	Human	7.2	pKd	=	7.2	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	421	8	2	4	4.3	O=C(CCCCCN1CCN(c2ccccc2O)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
		11432177	85122	0	None	-1	4	Human	8.0	pKd	=	8.0	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	435	9	1	4	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
		CHEMBL224820	85122	0	None	-1	4	Human	8.0	pKd	=	8.0	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	435	9	1	4	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
		3233	3512	44	None	2	12	Human	8.0	pKd	=	8.0	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2011.05.010
		3247	3512	44	None	2	12	Human	8.0	pKd	=	8.0	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2011.05.010
		6604889	3512	44	None	2	12	Human	8.0	pKd	=	8.0	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2011.05.010
		CHEMBL282199	3512	44	None	2	12	Human	8.0	pKd	=	8.0	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2011.05.010
		DB13988	3512	44	None	2	12	Human	8.0	pKd	=	8.0	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2011.05.010
		1809	134	32	None	-2	36	Rat	10.5	pKi	=	10.5	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm9911433
		4	134	32	None	-2	36	Rat	10.5	pKi	=	10.5	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm9911433
		CHEMBL18840	134	32	None	-2	36	Rat	10.5	pKi	=	10.5	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm9911433
		56944082	112078	0	None	169	4	Human	10.0	pKi	=	10	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	466	8	1	6	3.5	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
		CHEMBL3289972	112078	0	None	169	4	Human	10.0	pKi	=	10	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	466	8	1	6	3.5	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
		5	139	72	None	-3	54	Human	10.0	pKi	=	10.0	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2013.01.044
		5202	139	72	None	-3	54	Human	10.0	pKi	=	10.0	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2013.01.044
		CHEMBL39	139	72	None	-3	54	Human	10.0	pKi	=	10.0	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2013.01.044
		DB08839	139	72	None	-3	54	Human	10.0	pKi	=	10.0	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2013.01.044
		1809	134	32	None	-2	36	Rat	9.9	pKi	=	9.9	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm030826m
		4	134	32	None	-2	36	Rat	9.9	pKi	=	9.9	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm030826m
		CHEMBL18840	134	32	None	-2	36	Rat	9.9	pKi	=	9.9	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm030826m
		5	139	72	None	-3	54	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm2006782
		5202	139	72	None	-3	54	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm2006782
		CHEMBL39	139	72	None	-3	54	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm2006782
		DB08839	139	72	None	-3	54	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm2006782
		23643664	2350	8	None	-1	5	Rat	9.9	pKi	=	9.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm070487n
		8434	2350	8	None	-1	5	Rat	9.9	pKi	=	9.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm070487n
		CHEMBL243954	2350	8	None	-1	5	Rat	9.9	pKi	=	9.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm070487n
		42631003	199618	13	None	2	8	Human	9.8	pKi	=	9.8	Binding	Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	304	3	0	2	4.2	Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1	10.1016/j.ejmech.2022.114464
		CHEMBL592752	199618	13	None	2	8	Human	9.8	pKi	=	9.8	Binding	Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	304	3	0	2	4.2	Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1	10.1016/j.ejmech.2022.114464
		42631003	199618	13	None	2	8	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]lysergic acid from 5-HT7 receptor (unknown origin)Displacement of [3H]lysergic acid from 5-HT7 receptor (unknown origin)	ChEMBL	304	3	0	2	4.2	Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1	10.1021/acs.jmedchem.7b01898
		CHEMBL592752	199618	13	None	2	8	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]lysergic acid from 5-HT7 receptor (unknown origin)Displacement of [3H]lysergic acid from 5-HT7 receptor (unknown origin)	ChEMBL	304	3	0	2	4.2	Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1	10.1021/acs.jmedchem.7b01898
		168271260	190516	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	432	7	0	5	3.0	O=S(=O)(c1ccccc1F)N1CCC[C@@H]1CCCN1CCN(c2ccccn2)CC1	10.1021/acs.jmedchem.2c00633
		CHEMBL5179460	190516	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	432	7	0	5	3.0	O=S(=O)(c1ccccc1F)N1CCC[C@@H]1CCCN1CCN(c2ccccn2)CC1	10.1021/acs.jmedchem.2c00633
		5	139	72	None	-3	54	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01422
		5202	139	72	None	-3	54	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01422
		CHEMBL39	139	72	None	-3	54	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01422
		DB08839	139	72	None	-3	54	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01422
		10450593	124265	0	None	75	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	351	8	2	4	4.9	C[C@H](Nc1ccnc(NCCOc2ccc(F)cc2)c1)c1ccccc1	10.1016/j.bmcl.2010.03.012
		CHEMBL363452	124265	0	None	75	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	351	8	2	4	4.9	C[C@H](Nc1ccnc(NCCOc2ccc(F)cc2)c1)c1ccccc1	10.1016/j.bmcl.2010.03.012
		10450593	124265	0	None	75	3	Human	9.7	pKi	=	9.7	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	351	8	2	4	4.9	C[C@H](Nc1ccnc(NCCOc2ccc(F)cc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		CHEMBL363452	124265	0	None	75	3	Human	9.7	pKi	=	9.7	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	351	8	2	4	4.9	C[C@H](Nc1ccnc(NCCOc2ccc(F)cc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		66801551	112123	0	None	3	4	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	519	8	1	6	5.6	Cc1c(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
		CHEMBL3290016	112123	0	None	3	4	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	519	8	1	6	5.6	Cc1c(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
		46224879	201547	3	None	1	7	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	302	2	0	2	4.6	Cc1ccc2c(c1)c1c(n2/C=C\c2ccccc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
		CHEMBL605405	201547	3	None	1	7	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	302	2	0	2	4.6	Cc1ccc2c(c1)c1c(n2/C=C\c2ccccc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
		168287666	191660	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	465	7	0	4	4.2	O=S(=O)(c1ccccc1F)N1CCC[C@@H]1CCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.2c00633
		CHEMBL5196234	191660	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	465	7	0	4	4.2	O=S(=O)(c1ccccc1F)N1CCC[C@@H]1CCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.2c00633
		11224758	2353	5	None	-4	6	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1016/j.ejmech.2014.03.005
		8435	2353	5	None	-4	6	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1016/j.ejmech.2014.03.005
		CHEMBL225284	2353	5	None	-4	6	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1016/j.ejmech.2014.03.005
		11224758	2353	5	None	-4	6	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1016/j.ejmech.2014.12.041
		8435	2353	5	None	-4	6	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1016/j.ejmech.2014.12.041
		CHEMBL225284	2353	5	None	-4	6	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1016/j.ejmech.2014.12.041
		11224758	2353	5	None	-4	6	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1016/j.ejmech.2014.08.023
		8435	2353	5	None	-4	6	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1016/j.ejmech.2014.08.023
		CHEMBL225284	2353	5	None	-4	6	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1016/j.ejmech.2014.08.023
		11224758	2353	5	None	4	6	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/acs.jmedchem.5b00982
		8435	2353	5	None	4	6	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/acs.jmedchem.5b00982
		CHEMBL225284	2353	5	None	4	6	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/acs.jmedchem.5b00982
		11224758	2353	5	None	4	6	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]LSD from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assay	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/acs.jmedchem.7b01898
		8435	2353	5	None	4	6	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]LSD from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assay	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/acs.jmedchem.7b01898
		CHEMBL225284	2353	5	None	4	6	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]LSD from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assay	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/acs.jmedchem.7b01898
		11224758	2353	5	None	4	6	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/jm049702f
		8435	2353	5	None	4	6	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/jm049702f
		CHEMBL225284	2353	5	None	4	6	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/jm049702f
		5	139	72	None	-3	54	Human	9.7	pKi	=	9.7	Binding	Displacement of radiolabeled serotonin from human 5HT7 receptorDisplacement of radiolabeled serotonin from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8007618
		5202	139	72	None	-3	54	Human	9.7	pKi	=	9.7	Binding	Displacement of radiolabeled serotonin from human 5HT7 receptorDisplacement of radiolabeled serotonin from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8007618
		CHEMBL39	139	72	None	-3	54	Human	9.7	pKi	=	9.7	Binding	Displacement of radiolabeled serotonin from human 5HT7 receptorDisplacement of radiolabeled serotonin from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8007618
		DB08839	139	72	None	-3	54	Human	9.7	pKi	=	9.7	Binding	Displacement of radiolabeled serotonin from human 5HT7 receptorDisplacement of radiolabeled serotonin from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8007618
		10402615	202517	0	None	20	3	Rat	9.6	pKi	=	9.6	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	301	2	0	1	4.9	CN(C)[C@H]1CCc2c(cccc2-c2cccc3ccccc23)C1	10.1021/jm030826m
		CHEMBL611472	202517	0	None	20	3	Rat	9.6	pKi	=	9.6	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	301	2	0	1	4.9	CN(C)[C@H]1CCc2c(cccc2-c2cccc3ccccc23)C1	10.1021/jm030826m
		42631003	199618	13	None	2	8	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	304	3	0	2	4.2	Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
		CHEMBL592752	199618	13	None	2	8	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	304	3	0	2	4.2	Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
		145989143	167186	0	None	2	2	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	399	5	1	2	5.3	Fc1ccc2[nH]cc(CCN3CCN(c4ccccc4-c4ccccc4)CC3)c2c1	10.1016/j.ejmech.2017.12.063
		CHEMBL4291322	167186	0	None	2	2	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	399	5	1	2	5.3	Fc1ccc2[nH]cc(CCN3CCN(c4ccccc4-c4ccccc4)CC3)c2c1	10.1016/j.ejmech.2017.12.063
		44393091	65357	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	317	7	2	3	4.9	C[C@H](Nc1ccnc(NCCc2ccccc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		CHEMBL182923	65357	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	317	7	2	3	4.9	C[C@H](Nc1ccnc(NCCc2ccccc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		44393169	65596	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	352	8	2	5	4.3	C[C@H](Nc1ccnc(NCCOc2ccc(F)cc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		CHEMBL183277	65596	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	352	8	2	5	4.3	C[C@H](Nc1ccnc(NCCOc2ccc(F)cc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		71454999	81422	0	None	169	4	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	420	8	1	4	3.8	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159465	81422	0	None	169	4	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	420	8	1	4	3.8	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2012.07.043
		1809	134	32	None	-7	36	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm3003679
		4	134	32	None	-7	36	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm3003679
		CHEMBL18840	134	32	None	-7	36	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm3003679
		46233450	200243	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	357	6	0	1	6.5	CCCN(CCC)[C@H]1CCc2c(cccc2-c2cccc3ccccc23)C1	10.1016/j.bmc.2010.01.035
		CHEMBL596959	200243	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	357	6	0	1	6.5	CCCN(CCC)[C@H]1CCc2c(cccc2-c2cccc3ccccc23)C1	10.1016/j.bmc.2010.01.035
		10413595	161841	0	None	-1	11	Human	9.5	pKi	=	9.5	Binding	Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)	ChEMBL	499	4	1	5	2.5	COc1ccc(S(=O)(=O)N2CCc3ccc(I)cc32)cc1N1CCNCC1	10.1016/s0960-894x(00)00597-7
		CHEMBL414628	161841	0	None	-1	11	Human	9.5	pKi	=	9.5	Binding	Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)	ChEMBL	499	4	1	5	2.5	COc1ccc(S(=O)(=O)N2CCc3ccc(I)cc32)cc1N1CCNCC1	10.1016/s0960-894x(00)00597-7
		168283786	190870	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	465	7	0	4	4.2	O=S(=O)(c1ccc(F)cc1)N1CCC[C@@H]1CCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.2c00633
		CHEMBL5184712	190870	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	465	7	0	4	4.2	O=S(=O)(c1ccc(F)cc1)N1CCC[C@@H]1CCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.2c00633
		3233	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
		3247	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
		6604889	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
		CHEMBL282199	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
		DB13988	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
		3233	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.01.043
		3247	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.01.043
		6604889	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.01.043
		CHEMBL282199	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.01.043
		DB13988	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.01.043
		3233	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
		3247	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
		6604889	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
		CHEMBL282199	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
		DB13988	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
		3233	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
		3247	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
		6604889	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
		CHEMBL282199	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
		DB13988	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
		3233	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
		3247	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
		6604889	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
		CHEMBL282199	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
		DB13988	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
		3233	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.01.043
		3247	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.01.043
		6604889	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.01.043
		CHEMBL282199	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.01.043
		DB13988	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.01.043
		3233	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2014.07.026
		3247	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2014.07.026
		6604889	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2014.07.026
		CHEMBL282199	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2014.07.026
		DB13988	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2014.07.026
		3233	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
		3247	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
		6604889	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
		CHEMBL282199	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
		DB13988	3512	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
		1809	134	32	None	-7	36	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.ejmech.2020.112395
		4	134	32	None	-7	36	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.ejmech.2020.112395
		CHEMBL18840	134	32	None	-7	36	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.ejmech.2020.112395
		11524413	96375	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
		CHEMBL261719	96375	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
		11589069	96247	0	None	10	8	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	383	6	1	3	4.4	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm070279v
		CHEMBL260994	96247	0	None	10	8	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	383	6	1	3	4.4	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm070279v
		11524413	96375	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		CHEMBL261719	96375	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		11524413	96375	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		CHEMBL261719	96375	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		44126269	201484	5	None	2	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	318	3	0	2	4.5	Cc1ccc(CCn2c3c(c4cc(C)ccc42)CN(C)CC3)cc1	10.1016/j.bmcl.2009.11.037
		CHEMBL605081	201484	5	None	2	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	318	3	0	2	4.5	Cc1ccc(CCn2c3c(c4cc(C)ccc42)CN(C)CC3)cc1	10.1016/j.bmcl.2009.11.037
		1809	134	32	None	-7	36	Human	9.4	pKi	=	9.4	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm0341204
		4	134	32	None	-7	36	Human	9.4	pKi	=	9.4	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm0341204
		CHEMBL18840	134	32	None	-7	36	Human	9.4	pKi	=	9.4	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm0341204
		44393073	64463	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	333	8	2	4	4.7	C[C@H](Nc1ccnc(NCCOc2ccccc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		CHEMBL181356	64463	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	333	8	2	4	4.7	C[C@H](Nc1ccnc(NCCOc2ccccc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		44393092	64580	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	335	7	2	3	5.0	C[C@H](Nc1ccnc(NCCc2ccc(F)cc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		CHEMBL181605	64580	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	335	7	2	3	5.0	C[C@H](Nc1ccnc(NCCc2ccc(F)cc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		44393193	65641	0	None	32	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	351	8	2	4	4.9	C[C@H](Nc1cc(NCCOc2ccc(F)cc2)ccn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		CHEMBL183423	65641	0	None	32	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	351	8	2	4	4.9	C[C@H](Nc1cc(NCCOc2ccc(F)cc2)ccn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		44393192	66253	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	333	8	2	4	4.7	C[C@H](Nc1cc(NCCOc2ccccc2)ccn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		CHEMBL184607	66253	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	333	8	2	4	4.7	C[C@H](Nc1cc(NCCOc2ccccc2)ccn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		2389	3331	118	None	-8	67	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2018.01.002
		5073	3331	118	None	-8	67	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2018.01.002
		96	3331	118	None	-8	67	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2018.01.002
		CHEMBL85	3331	118	None	-8	67	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2018.01.002
		DB00734	3331	118	None	-8	67	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2018.01.002
		145985050	165690	0	None	-3	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	6	4.9	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4245263	165690	0	None	-3	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	6	4.9	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1016/j.ejmech.2018.01.002
		1809	134	32	None	-7	36	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in CHO-K1 cells after 120 minsDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in CHO-K1 cells after 120 mins	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.ejmech.2013.09.018
		4	134	32	None	-7	36	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in CHO-K1 cells after 120 minsDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in CHO-K1 cells after 120 mins	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.ejmech.2013.09.018
		CHEMBL18840	134	32	None	-7	36	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in CHO-K1 cells after 120 minsDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in CHO-K1 cells after 120 mins	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.ejmech.2013.09.018
		24854273	158372	0	None	112	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
		CHEMBL408976	158372	0	None	112	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
		56944763	112111	0	None	4	4	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	453	6	1	5	4.3	O=S(=O)(NCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
		CHEMBL3290004	112111	0	None	4	4	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	453	6	1	5	4.3	O=S(=O)(NCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
		44266163	97055	1	None	4	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	387	4	1	2	4.4	O=C1c2ccccc2CCCN1CCN1CCC(c2c[nH]c3ccccc23)CC1	10.1016/s0960-894x(03)00077-5
		CHEMBL267062	97055	1	None	4	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	387	4	1	2	4.4	O=C1c2ccccc2CCCN1CCN1CCC(c2c[nH]c3ccccc23)CC1	10.1016/s0960-894x(03)00077-5
		24854273	158372	0	None	112	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		CHEMBL408976	158372	0	None	112	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		24854187	96227	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	395	7	1	3	4.4	CCC1(CCCCN2CCN(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
		CHEMBL260872	96227	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	395	7	1	3	4.4	CCC1(CCCCN2CCN(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
		24854187	96227	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	395	7	1	3	4.4	CCC1(CCCCN2CCN(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		CHEMBL260872	96227	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	395	7	1	3	4.4	CCC1(CCCCN2CCN(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		132578545	154558	0	None	33	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	325	3	0	2	4.1	O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
		CHEMBL3898250	154558	0	None	33	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	325	3	0	2	4.1	O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
		CHEMBL3991133	154558	0	None	33	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	325	3	0	2	4.1	O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
		25192947	164666	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	273	4	1	4	2.5	Cc1nn(C)c(C)c1-c1ccc(O)c(CCN(C)C)c1	10.1016/j.ejmech.2019.111705
		CHEMBL4216782	164666	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	273	4	1	4	2.5	Cc1nn(C)c(C)c1-c1ccc(O)c(CCN(C)C)c1	10.1016/j.ejmech.2019.111705
		25192947	164666	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	273	4	1	4	2.5	Cc1nn(C)c(C)c1-c1ccc(O)c(CCN(C)C)c1	10.1021/acs.jmedchem.7b01898
		CHEMBL4216782	164666	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	273	4	1	4	2.5	Cc1nn(C)c(C)c1-c1ccc(O)c(CCN(C)C)c1	10.1021/acs.jmedchem.7b01898
		1809	134	32	None	-7	36	Human	9.3	pKi	=	9.3	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm0104264
		4	134	32	None	-7	36	Human	9.3	pKi	=	9.3	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm0104264
		CHEMBL18840	134	32	None	-7	36	Human	9.3	pKi	=	9.3	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm0104264
		11653869	96293	0	None	134	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	383	6	1	3	4.4	O=C1Nc2ccccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1021/jm200547z
		CHEMBL261209	96293	0	None	134	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	383	6	1	3	4.4	O=C1Nc2ccccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1021/jm200547z
		11653869	96293	0	None	134	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	383	6	1	3	4.4	O=C1Nc2ccccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1021/jm070279v
		CHEMBL261209	96293	0	None	134	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	383	6	1	3	4.4	O=C1Nc2ccccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1021/jm070279v
		16362	3125	71	None	-5	30	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1021/jm030030n
		2172	3125	71	None	-5	30	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1021/jm030030n
		90	3125	71	None	-5	30	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1021/jm030030n
		CHEMBL1423	3125	71	None	-5	30	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1021/jm030030n
		DB01100	3125	71	None	-5	30	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1021/jm030030n
		213046	2385	59	None	2	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.ejmech.2019.111736
		4168	2385	59	None	2	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.ejmech.2019.111736
		7461	2385	59	None	2	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.ejmech.2019.111736
		CHEMBL1237021	2385	59	None	2	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.ejmech.2019.111736
		DB08815	2385	59	None	2	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.ejmech.2019.111736
		213046	2385	59	None	2	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrsDisplacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrs	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.bmc.2020.115459
		4168	2385	59	None	2	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrsDisplacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrs	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.bmc.2020.115459
		7461	2385	59	None	2	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrsDisplacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrs	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.bmc.2020.115459
		CHEMBL1237021	2385	59	None	2	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrsDisplacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrs	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.bmc.2020.115459
		DB08815	2385	59	None	2	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrsDisplacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrs	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.bmc.2020.115459
		132578545	154558	0	None	33	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	325	3	0	2	4.1	O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
		CHEMBL3898250	154558	0	None	33	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	325	3	0	2	4.1	O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
		CHEMBL3991133	154558	0	None	33	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	325	3	0	2	4.1	O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
		66801167	112109	0	None	3	4	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	467	7	1	5	4.7	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12	10.1021/jm401895u
		CHEMBL3290002	112109	0	None	3	4	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	467	7	1	5	4.7	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12	10.1021/jm401895u
		1809	134	32	None	-2	36	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm800615e
		4	134	32	None	-2	36	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm800615e
		CHEMBL18840	134	32	None	-2	36	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm800615e
		1809	134	32	None	-2	36	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm070487n
		4	134	32	None	-2	36	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm070487n
		CHEMBL18840	134	32	None	-2	36	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm070487n
		44340836	161734	0	None	60	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	471	7	1	4	4.4	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(Oc2ccc(F)cc2)CC1	10.1016/s0960-894x(02)00690-x
		CHEMBL413707	161734	0	None	60	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	471	7	1	4	4.4	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(Oc2ccc(F)cc2)CC1	10.1016/s0960-894x(02)00690-x
		1809	134	32	None	-2	36	Rat	9.3	pKi	=	9.3	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm020994z
		4	134	32	None	-2	36	Rat	9.3	pKi	=	9.3	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm020994z
		CHEMBL18840	134	32	None	-2	36	Rat	9.3	pKi	=	9.3	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm020994z
		1809	134	32	None	-2	36	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.bmc.2007.05.010
		1809	134	32	None	-2	36	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm049702f
		4	134	32	None	-2	36	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.bmc.2007.05.010
		4	134	32	None	-2	36	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm049702f
		CHEMBL18840	134	32	None	-2	36	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.bmc.2007.05.010
		CHEMBL18840	134	32	None	-2	36	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm049702f
		4106	2502	22	None	-4	34	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2020.112149
		5358812	2502	22	None	-4	34	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2020.112149
		89	2502	22	None	-4	34	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2020.112149
		CHEMBL93240	2502	22	None	-4	34	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2020.112149
		145983405	166438	0	None	32	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	449	6	1	2	6.0	Fc1cccc(-c2c(F)cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.ejmech.2017.12.063
		CHEMBL4277476	166438	0	None	32	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	449	6	1	2	6.0	Fc1cccc(-c2c(F)cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.ejmech.2017.12.063
		44266221	208366	0	None	12	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	405	4	0	3	4.5	O=C1c2ccccc2CCCN1CCN1CCC(n2ccc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
		CHEMBL9951	208366	0	None	12	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	405	4	0	3	4.5	O=C1c2ccccc2CCCN1CCN1CCC(n2ccc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
		4106	2502	22	None	-4	34	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/acs.jmedchem.1c00497
		5358812	2502	22	None	-4	34	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/acs.jmedchem.1c00497
		89	2502	22	None	-4	34	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/acs.jmedchem.1c00497
		CHEMBL93240	2502	22	None	-4	34	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/acs.jmedchem.1c00497
		25107716	2351	43	None	3	7	Rat	9.2	pKi	=	9.2	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.bmc.2014.01.016
		8436	2351	43	None	3	7	Rat	9.2	pKi	=	9.2	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.bmc.2014.01.016
		CHEMBL522691	2351	43	None	3	7	Rat	9.2	pKi	=	9.2	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.bmc.2014.01.016
		25107716	2351	43	None	3	7	Rat	9.2	pKi	=	9.2	Binding	Binding affinity to rat cloned 5HT7 receptorBinding affinity to rat cloned 5HT7 receptor	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm3003679
		8436	2351	43	None	3	7	Rat	9.2	pKi	=	9.2	Binding	Binding affinity to rat cloned 5HT7 receptorBinding affinity to rat cloned 5HT7 receptor	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm3003679
		CHEMBL522691	2351	43	None	3	7	Rat	9.2	pKi	=	9.2	Binding	Binding affinity to rat cloned 5HT7 receptorBinding affinity to rat cloned 5HT7 receptor	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm3003679
		25107716	2351	43	None	-3	7	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.ejmech.2014.03.005
		8436	2351	43	None	-3	7	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.ejmech.2014.03.005
		CHEMBL522691	2351	43	None	-3	7	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.ejmech.2014.03.005
		25107716	2351	43	None	-3	7	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.ejmech.2012.07.043
		8436	2351	43	None	-3	7	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.ejmech.2012.07.043
		CHEMBL522691	2351	43	None	-3	7	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.ejmech.2012.07.043
		25107716	2351	43	None	3	7	Rat	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm800615e
		8436	2351	43	None	3	7	Rat	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm800615e
		CHEMBL522691	2351	43	None	3	7	Rat	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm800615e
		23642275	482	31	None	60	3	Human	9.2	pKi	=	9.2	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1016/j.ejmech.2019.111705
		8433	482	31	None	60	3	Human	9.2	pKi	=	9.2	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1016/j.ejmech.2019.111705
		CHEMBL2164327	482	31	None	60	3	Human	9.2	pKi	=	9.2	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1016/j.ejmech.2019.111705
		9881600	55197	4	None	8	5	Human	9.2	pKi	=	9.2	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1cccc(-c2ccccc2)n1	10.1016/j.ejmech.2019.111705
		CHEMBL161765	55197	4	None	8	5	Human	9.2	pKi	=	9.2	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1cccc(-c2ccccc2)n1	10.1016/j.ejmech.2019.111705
		44393180	66665	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	318	7	2	4	4.3	C[C@H](Nc1ccnc(NCCc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		CHEMBL185384	66665	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	318	7	2	4	4.3	C[C@H](Nc1ccnc(NCCc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		23642275	482	31	None	60	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.7b01898
		8433	482	31	None	60	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.7b01898
		CHEMBL2164327	482	31	None	60	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.7b01898
		9881600	55197	4	None	8	5	Human	9.2	pKi	=	9.2	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constant	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1cccc(-c2ccccc2)n1	10.1016/j.ejmech.2019.111690
		CHEMBL161765	55197	4	None	8	5	Human	9.2	pKi	=	9.2	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constant	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1cccc(-c2ccccc2)n1	10.1016/j.ejmech.2019.111690
		23642275	482	31	None	60	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity to human 5HT7 receptor expressed in HEK-293F cellsBinding affinity to human 5HT7 receptor expressed in HEK-293F cells	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1016/j.bmc.2013.02.038
		8433	482	31	None	60	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity to human 5HT7 receptor expressed in HEK-293F cellsBinding affinity to human 5HT7 receptor expressed in HEK-293F cells	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1016/j.bmc.2013.02.038
		CHEMBL2164327	482	31	None	60	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity to human 5HT7 receptor expressed in HEK-293F cellsBinding affinity to human 5HT7 receptor expressed in HEK-293F cells	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1016/j.bmc.2013.02.038
		9881600	55197	4	None	8	5	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1cccc(-c2ccccc2)n1	10.1016/j.bmcl.2003.11.050
		CHEMBL161765	55197	4	None	8	5	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1cccc(-c2ccccc2)n1	10.1016/j.bmcl.2003.11.050
		66803474	156316	0	None	3	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	429	6	2	3	4.2	Cc1cccc(S(=O)(=O)NCCN2CC=C(c3c[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
		CHEMBL4065568	156316	0	None	3	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	429	6	2	3	4.2	Cc1cccc(S(=O)(=O)NCCN2CC=C(c3c[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
		11681111	120584	0	None	7	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	309	3	2	2	2.4	CCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
		CHEMBL3343666	120584	0	None	7	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	309	3	2	2	2.4	CCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
		CHEMBL3545815	120584	0	None	7	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	309	3	2	2	2.4	CCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
		4431	2729	25	None	-20	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	393	7	0	5	2.9	COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2	10.1016/j.ejmech.2014.08.023
		73	2729	25	None	-20	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	393	7	0	5	2.9	COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2	10.1016/j.ejmech.2014.08.023
		CHEMBL8618	2729	25	None	-20	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	393	7	0	5	2.9	COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2	10.1016/j.ejmech.2014.08.023
		9881600	55197	4	None	8	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5CT from 5HT7B receptorDisplacement of [3H]5CT from 5HT7B receptor	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1cccc(-c2ccccc2)n1	10.1016/j.bmc.2010.01.035
		CHEMBL161765	55197	4	None	8	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5CT from 5HT7B receptorDisplacement of [3H]5CT from 5HT7B receptor	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1cccc(-c2ccccc2)n1	10.1016/j.bmc.2010.01.035
		24854371	95875	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
		CHEMBL259087	95875	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
		23642275	482	31	None	60	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1039/C8MD00313K
		8433	482	31	None	60	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1039/C8MD00313K
		CHEMBL2164327	482	31	None	60	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1039/C8MD00313K
		56933434	112097	0	None	6	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	431	7	1	5	3.8	Cc1cccc(S(=O)(=O)NCCCN2CCC(c3noc4cc(F)ccc34)CC2)c1	10.1021/jm401895u
		CHEMBL3289991	112097	0	None	6	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	431	7	1	5	3.8	Cc1cccc(S(=O)(=O)NCCCN2CCC(c3noc4cc(F)ccc34)CC2)c1	10.1021/jm401895u
		25107716	2351	43	None	-3	7	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysis	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1039/C8MD00313K
		8436	2351	43	None	-3	7	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysis	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1039/C8MD00313K
		CHEMBL522691	2351	43	None	-3	7	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysis	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1039/C8MD00313K
		24853955	156193	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(F)c(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		CHEMBL406414	156193	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(F)c(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		5	139	72	None	-5	54	Rat	9.2	pKi	=	9.2	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030826m
		5202	139	72	None	-5	54	Rat	9.2	pKi	=	9.2	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030826m
		CHEMBL39	139	72	None	-5	54	Rat	9.2	pKi	=	9.2	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030826m
		DB08839	139	72	None	-5	54	Rat	9.2	pKi	=	9.2	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030826m
		44437334	150498	0	None	-	1	Rat	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	694	18	0	9	5.9	COc1ccccc1N1CCN(CCc2cccc(OCCOCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		CHEMBL395444	150498	0	None	-	1	Rat	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	694	18	0	9	5.9	COc1ccccc1N1CCN(CCc2cccc(OCCOCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		24854371	95875	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		CHEMBL259087	95875	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		24854037	95874	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	425	7	1	3	5.2	CCC1(CCCCN2CCN(c3ccc(C)c(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		CHEMBL259086	95874	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	425	7	1	3	5.2	CCC1(CCCCN2CCN(c3ccc(C)c(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		24854041	95979	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2cc(F)ccc21	10.1021/jm070279v
		CHEMBL259549	95979	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2cc(F)ccc21	10.1021/jm070279v
		9934709	167824	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	476	6	2	3	5.1	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(c2c[nH]c3ccccc23)CC1	10.1016/s0960-894x(02)00690-x
		CHEMBL430706	167824	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	476	6	2	3	5.1	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(c2c[nH]c3ccccc23)CC1	10.1016/s0960-894x(02)00690-x
		9934709	167824	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	476	6	2	3	5.1	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(c2c[nH]c3ccccc23)CC1	10.1016/j.bmcl.2010.03.012
		CHEMBL430706	167824	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	476	6	2	3	5.1	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(c2c[nH]c3ccccc23)CC1	10.1016/j.bmcl.2010.03.012
		102364516	113543	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	346	6	0	2	4.0	O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1	10.1016/j.ejmech.2019.111705
		CHEMBL3321794	113543	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	346	6	0	2	4.0	O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1	10.1016/j.ejmech.2019.111705
		10015688	51674	1	None	12	4	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	264	5	0	3	3.8	CN(C)CCSc1cccc(C2CCCCC2)n1	10.1016/j.bmcl.2003.11.050
		CHEMBL158402	51674	1	None	12	4	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	264	5	0	3	3.8	CN(C)CCSc1cccc(C2CCCCC2)n1	10.1016/j.bmcl.2003.11.050
		10015688	51674	1	None	12	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	264	5	0	3	3.8	CN(C)CCSc1cccc(C2CCCCC2)n1	10.1016/j.bmc.2010.01.035
		CHEMBL158402	51674	1	None	12	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	264	5	0	3	3.8	CN(C)CCSc1cccc(C2CCCCC2)n1	10.1016/j.bmc.2010.01.035
		102364516	113543	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	346	6	0	2	4.0	O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1	10.1021/jm500880c
		CHEMBL3321794	113543	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	346	6	0	2	4.0	O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1	10.1021/jm500880c
		66801263	112076	0	None	14	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	482	8	1	6	4.0	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
		CHEMBL3289970	112076	0	None	14	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	482	8	1	6	4.0	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
		66801210	112124	0	None	1	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	535	8	1	6	6.1	Cc1c(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(Cl)cc12	10.1021/jm401895u
		CHEMBL3290017	112124	0	None	1	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	535	8	1	6	6.1	Cc1c(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(Cl)cc12	10.1021/jm401895u
		44340854	10059	0	None	61	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	493	6	2	6	4.1	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(n2c(O)nc3ccccc32)CC1	10.1016/s0960-894x(02)00690-x
		CHEMBL115262	10059	0	None	61	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	493	6	2	6	4.1	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(n2c(O)nc3ccccc32)CC1	10.1016/s0960-894x(02)00690-x
		3233	3512	44	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2016.06.080
		3247	3512	44	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2016.06.080
		6604889	3512	44	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2016.06.080
		CHEMBL282199	3512	44	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2016.06.080
		DB13988	3512	44	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2016.06.080
		3233	3512	44	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.12.039
		3247	3512	44	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.12.039
		6604889	3512	44	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.12.039
		CHEMBL282199	3512	44	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.12.039
		DB13988	3512	44	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.12.039
		3233	3512	44	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2015.02.042
		3247	3512	44	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2015.02.042
		6604889	3512	44	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2015.02.042
		CHEMBL282199	3512	44	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2015.02.042
		DB13988	3512	44	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2015.02.042
		168297777	192904	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity to rat brain 5-HT7 receptor assessed as inhibition constant incubated for 60 minsBinding affinity to rat brain 5-HT7 receptor assessed as inhibition constant incubated for 60 mins	ChEMBL	398	8	0	4	3.3	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(OCCF)c2)CC1	10.1021/acs.jmedchem.2c00633
		CHEMBL5184185	192904	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity to rat brain 5-HT7 receptor assessed as inhibition constant incubated for 60 minsBinding affinity to rat brain 5-HT7 receptor assessed as inhibition constant incubated for 60 mins	ChEMBL	398	8	0	4	3.3	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(OCCF)c2)CC1	10.1021/acs.jmedchem.2c00633
		CHEMBL5222088	192904	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity to rat brain 5-HT7 receptor assessed as inhibition constant incubated for 60 minsBinding affinity to rat brain 5-HT7 receptor assessed as inhibition constant incubated for 60 mins	ChEMBL	398	8	0	4	3.3	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(OCCF)c2)CC1	10.1021/acs.jmedchem.2c00633
		145974165	164588	0	None	8	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method	ChEMBL	410	5	0	2	6.0	Clc1ccc(CCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1Cl	10.1016/j.bmcl.2017.11.007
		CHEMBL4215605	164588	0	None	8	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method	ChEMBL	410	5	0	2	6.0	Clc1ccc(CCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1Cl	10.1016/j.bmcl.2017.11.007
		118717217	120576	0	None	2	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	325	4	2	3	1.6	COCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
		CHEMBL3343667	120576	0	None	2	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	325	4	2	3	1.6	COCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
		CHEMBL3545762	120576	0	None	2	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	325	4	2	3	1.6	COCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
		24829343	159021	0	None	24	9	Human	9.1	pKi	=	9.1	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21	10.1016/j.ejmech.2019.111705
		CHEMBL409662	159021	0	None	24	9	Human	9.1	pKi	=	9.1	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21	10.1016/j.ejmech.2019.111705
		24829343	159021	0	None	24	9	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21	10.1021/jm200547z
		CHEMBL409662	159021	0	None	24	9	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21	10.1021/jm200547z
		24829343	159021	0	None	24	9	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21	10.1021/jm070279v
		CHEMBL409662	159021	0	None	24	9	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21	10.1021/jm070279v
		145991084	166870	0	None	7	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	417	5	1	2	5.5	Fc1cccc(-c2ccccc2N2CCN(CCc3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.ejmech.2017.12.063
		CHEMBL4285796	166870	0	None	7	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	417	5	1	2	5.5	Fc1cccc(-c2ccccc2N2CCN(CCc3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.ejmech.2017.12.063
		44340835	10408	0	None	117	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	499	7	1	4	5.0	O=C(c1ccc(Cl)cc1)C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/s0960-894x(02)00690-x
		CHEMBL116292	10408	0	None	117	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	499	7	1	4	5.0	O=C(c1ccc(Cl)cc1)C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/s0960-894x(02)00690-x
		155568606	176108	0	None	-3	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	532	9	1	6	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
		CHEMBL4591601	176108	0	None	-3	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	532	9	1	6	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
		5	139	72	None	-3	54	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.12.045
		5202	139	72	None	-3	54	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.12.045
		CHEMBL39	139	72	None	-3	54	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.12.045
		DB08839	139	72	None	-3	54	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.12.045
		5	139	72	None	-3	54	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm401895u
		5202	139	72	None	-3	54	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm401895u
		CHEMBL39	139	72	None	-3	54	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm401895u
		DB08839	139	72	None	-3	54	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm401895u
		66801158	112084	0	None	-1	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	464	8	1	6	3.9	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
		CHEMBL3289978	112084	0	None	-1	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	464	8	1	6	3.9	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
		56944665	112110	0	None	-1	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	481	8	1	5	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12	10.1021/jm401895u
		CHEMBL3290003	112110	0	None	-1	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	481	8	1	5	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12	10.1021/jm401895u
		56944668	112112	0	None	1	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	467	7	1	5	4.7	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
		CHEMBL3290005	112112	0	None	1	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	467	7	1	5	4.7	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
		25107518	187284	0	None	20	4	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	441	10	1	3	5.4	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccccc1	10.1021/jm800615e
		CHEMBL492871	187284	0	None	20	4	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	441	10	1	3	5.4	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccccc1	10.1021/jm800615e
		9971032	202205	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	282	2	1	1	4.0	Cc1[nH]c(C)c(-c2cccc3c2CC[C@H](N(C)C)C3)c1C	10.1021/jm030826m
		CHEMBL609675	202205	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	282	2	1	1	4.0	Cc1[nH]c(C)c(-c2cccc3c2CC[C@H](N(C)C)C3)c1C	10.1021/jm030826m
		44340850	9902	0	None	22	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	483	7	1	4	4.4	O=C(c1ccc(F)cc1)C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/s0960-894x(02)00690-x
		CHEMBL114345	9902	0	None	22	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	483	7	1	4	4.4	O=C(c1ccc(F)cc1)C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/s0960-894x(02)00690-x
		155516399	170071	0	None	47	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	368	6	1	5	3.1	O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2ccsc12	10.1016/j.ejmech.2019.111690
		CHEMBL4443201	170071	0	None	47	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	368	6	1	5	3.1	O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2ccsc12	10.1016/j.ejmech.2019.111690
		10069973	52399	0	None	4	5	Rat	9.1	pKi	=	9.1	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	407	9	0	6	4.4	COc1ccccc1C(=O)CCCCCN1CCN(c2noc3ccccc23)CC1	10.1021/jm020994z
		CHEMBL159022	52399	0	None	4	5	Rat	9.1	pKi	=	9.1	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	407	9	0	6	4.4	COc1ccccc1C(=O)CCCCCN1CCN(c2noc3ccccc23)CC1	10.1021/jm020994z
		155552188	174064	0	None	7	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	421	6	2	3	4.6	Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2cn[nH]c2)c1	10.1016/j.bmcl.2019.126703
		CHEMBL4544153	174064	0	None	7	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	421	6	2	3	4.6	Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2cn[nH]c2)c1	10.1016/j.bmcl.2019.126703
		1809	134	32	None	-7	36	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm030030n
		4	134	32	None	-7	36	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm030030n
		CHEMBL18840	134	32	None	-7	36	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm030030n
		4106	2502	22	None	-4	34	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm401895u
		5358812	2502	22	None	-4	34	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm401895u
		89	2502	22	None	-4	34	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm401895u
		CHEMBL93240	2502	22	None	-4	34	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm401895u
		66801234	112101	0	None	1	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	469	7	1	5	4.3	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
		CHEMBL3289995	112101	0	None	1	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	469	7	1	5	4.3	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
		66801271	112105	0	None	5	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	423	7	1	6	3.6	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccs1	10.1021/jm401895u
		CHEMBL3289999	112105	0	None	5	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	423	7	1	6	3.6	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccs1	10.1021/jm401895u
		66801139	112116	0	None	1	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	473	7	1	6	4.7	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1csc2ccccc12	10.1021/jm401895u
		CHEMBL3290009	112116	0	None	1	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	473	7	1	6	4.7	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1csc2ccccc12	10.1021/jm401895u
		23643870	92864	0	None	35	3	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	448	9	1	4	4.6	CN(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
		CHEMBL243955	92864	0	None	35	3	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	448	9	1	4	4.6	CN(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
		44437328	90982	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	678	17	0	8	6.7	COc1ccccc1N1CCN(CCc2cccc(OCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		CHEMBL239656	90982	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	678	17	0	8	6.7	COc1ccccc1N1CCN(CCc2cccc(OCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		1809	134	32	None	-7	36	Human	9.0	pKi	=	9.0	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/acs.jmedchem.7b01898
		4	134	32	None	-7	36	Human	9.0	pKi	=	9.0	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/acs.jmedchem.7b01898
		CHEMBL18840	134	32	None	-7	36	Human	9.0	pKi	=	9.0	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/acs.jmedchem.7b01898
		107	141	121	None	-1	30	Rat	9.0	pKi	=	9.0	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1021/jm030826m
		1833	141	121	None	-1	30	Rat	9.0	pKi	=	9.0	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1021/jm030826m
		CHEMBL8165	141	121	None	-1	30	Rat	9.0	pKi	=	9.0	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1021/jm030826m
		25107520	187593	0	None	70	3	Rat	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	442	10	1	4	4.7	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1	10.1021/jm800615e
		CHEMBL494709	187593	0	None	70	3	Rat	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	442	10	1	4	4.7	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1	10.1021/jm800615e
		141745651	175346	0	None	1	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	380	4	1	4	4.3	Fc1ccc2[nH]cc(CCN3CCN(c4nsc5ccccc45)CC3)c2c1	10.1016/j.bmcl.2019.126703
		CHEMBL4574299	175346	0	None	1	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	380	4	1	4	4.3	Fc1ccc2[nH]cc(CCN3CCN(c4nsc5ccccc45)CC3)c2c1	10.1016/j.bmcl.2019.126703
		118713589	114374	0	None	10	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	381	6	0	5	4.0	Cc1ccccc1N1CCN(CCCCn2c(=O)sc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
		CHEMBL3331258	114374	0	None	10	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	381	6	0	5	4.0	Cc1ccccc1N1CCN(CCCCn2c(=O)sc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
		44393134	64849	0	None	39	2	Human	9.0	pKi	=	9	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	352	8	2	5	4.3	CC(Nc1nccc(NCCOc2ccc(F)cc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		CHEMBL182071	64849	0	None	39	2	Human	9.0	pKi	=	9	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	352	8	2	5	4.3	CC(Nc1nccc(NCCOc2ccc(F)cc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		4184551	192661	9	None	-	1	Human	9.0	pKi	=	9	Binding	Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant	ChEMBL	352	5	1	4	2.7	CC1CCN(CCC2CCCN2S(=O)(=O)c2cccc(O)c2)CC1	10.1016/j.bmcl.2021.128275
		CHEMBL5218527	192661	9	None	-	1	Human	9.0	pKi	=	9	Binding	Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant	ChEMBL	352	5	1	4	2.7	CC1CCN(CCC2CCCN2S(=O)(=O)c2cccc(O)c2)CC1	10.1016/j.bmcl.2021.128275
		3233	3512	44	None	2	12	Human	9.0	pKi	=	9	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2010.11.078
		3247	3512	44	None	2	12	Human	9.0	pKi	=	9	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2010.11.078
		6604889	3512	44	None	2	12	Human	9.0	pKi	=	9	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2010.11.078
		CHEMBL282199	3512	44	None	2	12	Human	9.0	pKi	=	9	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2010.11.078
		DB13988	3512	44	None	2	12	Human	9.0	pKi	=	9	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2010.11.078
		7059581	167045	3	None	-1	2	Rat	9.0	pKi	=	9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2	10.1016/s0960-894x(00)00166-9
		CHEMBL428892	167045	3	None	-1	2	Rat	9.0	pKi	=	9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2	10.1016/s0960-894x(00)00166-9
		3233	3512	44	None	2	12	Human	9.0	pKi	=	9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/s0960-894x(02)00438-9
		3247	3512	44	None	2	12	Human	9.0	pKi	=	9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/s0960-894x(02)00438-9
		6604889	3512	44	None	2	12	Human	9.0	pKi	=	9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/s0960-894x(02)00438-9
		CHEMBL282199	3512	44	None	2	12	Human	9.0	pKi	=	9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/s0960-894x(02)00438-9
		DB13988	3512	44	None	2	12	Human	9.0	pKi	=	9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/s0960-894x(02)00438-9
		11725453	99080	0	None	1	6	Human	9.0	pKi	=	9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1016/s0960-894x(02)00438-9
		CHEMBL28056	99080	0	None	1	6	Human	9.0	pKi	=	9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1016/s0960-894x(02)00438-9
		3233	3512	44	None	-2	12	Rat	9.0	pKi	=	9	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm049743b
		3247	3512	44	None	-2	12	Rat	9.0	pKi	=	9	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm049743b
		6604889	3512	44	None	-2	12	Rat	9.0	pKi	=	9	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm049743b
		CHEMBL282199	3512	44	None	-2	12	Rat	9.0	pKi	=	9	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm049743b
		DB13988	3512	44	None	-2	12	Rat	9.0	pKi	=	9	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm049743b
		7059581	167045	3	None	-1	2	Rat	9.0	pKi	=	9	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2	10.1021/jm049743b
		CHEMBL428892	167045	3	None	-1	2	Rat	9.0	pKi	=	9	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2	10.1021/jm049743b
		127025243	137743	0	None	60	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	446	8	1	4	4.3	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2ccc(F)cc2)C3)c1	10.1016/j.ejmech.2015.11.040
		CHEMBL3759205	137743	0	None	60	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	446	8	1	4	4.3	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2ccc(F)cc2)C3)c1	10.1016/j.ejmech.2015.11.040
		145985692	165444	0	None	-3	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cccc2cnccc12)N1CCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4239091	165444	0	None	-3	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cccc2cnccc12)N1CCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
		118626161	165599	0	None	-1	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4242858	165599	0	None	-1	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
		118626129	165642	0	None	3	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4243848	165642	0	None	3	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
		156021386	178090	0	None	7	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	285	2	0	1	4.4	CN(C)[C@H]1CCc2c(cccc2-c2ccccc2Cl)C1	10.1016/j.bmc.2019.115262
		CHEMBL4647808	178090	0	None	7	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	285	2	0	1	4.4	CN(C)[C@H]1CCc2c(cccc2-c2ccccc2Cl)C1	10.1016/j.bmc.2019.115262
		4106	2502	22	None	-4	34	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/acs.jmedchem.7b00839
		5358812	2502	22	None	-4	34	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/acs.jmedchem.7b00839
		89	2502	22	None	-4	34	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/acs.jmedchem.7b00839
		CHEMBL93240	2502	22	None	-4	34	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/acs.jmedchem.7b00839
		66803595	159728	0	None	1	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	431	6	3	4	3.6	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(O)c1	10.1021/acs.jmedchem.7b00839
		CHEMBL4104622	159728	0	None	1	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	431	6	3	4	3.6	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(O)c1	10.1021/acs.jmedchem.7b00839
		155531753	171646	0	None	-1	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	548	11	1	7	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
		CHEMBL4465959	171646	0	None	-1	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	548	11	1	7	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
		19605739	170012	14	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	204	3	3	2	1.4	NCCc1c[nH]c2ccc(C(=O)O)cc12	10.1016/j.ejmech.2019.111705
		CHEMBL4442472	170012	14	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	204	3	3	2	1.4	NCCc1c[nH]c2ccc(C(=O)O)cc12	10.1016/j.ejmech.2019.111705
		2389	3331	118	None	-8	67	Human	9.0	pKi	=	9	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
		5073	3331	118	None	-8	67	Human	9.0	pKi	=	9	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
		96	3331	118	None	-8	67	Human	9.0	pKi	=	9	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
		CHEMBL85	3331	118	None	-8	67	Human	9.0	pKi	=	9	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
		DB00734	3331	118	None	-8	67	Human	9.0	pKi	=	9	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
		16006607	95672	4	None	10	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	219	2	2	4	2.1	CC(C)Oc1cccc2c1N=C(N)NC2C	10.1016/j.bmcl.2007.10.080
		CHEMBL258075	95672	4	None	10	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	219	2	2	4	2.1	CC(C)Oc1cccc2c1N=C(N)NC2C	10.1016/j.bmcl.2007.10.080
		7059581	167045	3	None	1	2	Human	9.0	pKi	=	9	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2	10.1021/jm030841r
		CHEMBL428892	167045	3	None	1	2	Human	9.0	pKi	=	9	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2	10.1021/jm030841r
		11661471	159528	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	408	7	1	2	5.9	CCC1(CCCCN2CC=C(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		CHEMBL410226	159528	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	408	7	1	2	5.9	CCC1(CCCCN2CC=C(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		10346043	47120	0	None	-1	3	Human	9.0	pKi	=	9.0	Binding	Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand(n=6)Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand(n=6)	ChEMBL	503	5	2	5	3.4	COc1ccc(S(=O)(=O)Nc2cc(Br)ccc2Br)cc1N1CCNCC1	10.1016/s0960-894x(00)00597-7
		CHEMBL154274	47120	0	None	-1	3	Human	9.0	pKi	=	9.0	Binding	Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand(n=6)Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand(n=6)	ChEMBL	503	5	2	5	3.4	COc1ccc(S(=O)(=O)Nc2cc(Br)ccc2Br)cc1N1CCNCC1	10.1016/s0960-894x(00)00597-7
		10379532	99275	0	None	1	6	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1016/j.bmcl.2010.03.012
		CHEMBL281923	99275	0	None	1	6	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1016/j.bmcl.2010.03.012
		10062885	99276	0	None	1	6	Human	9.0	pKi	=	9.0	Binding	Binding affinity at 5HT7 receptorBinding affinity at 5HT7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm060959i
		CHEMBL281924	99276	0	None	1	6	Human	9.0	pKi	=	9.0	Binding	Binding affinity at 5HT7 receptorBinding affinity at 5HT7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm060959i
		78108787	191967	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human recombinant 5-HT7 receptor assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor assessed as inhibition constant	ChEMBL	363	6	1	3	4.0	Cc1ccc(N2CCN(CCCCC3C(=O)Nc4ccccc43)CC2)cc1	10.1021/acs.jmedchem.2c00633
		CHEMBL5201016	191967	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human recombinant 5-HT7 receptor assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor assessed as inhibition constant	ChEMBL	363	6	1	3	4.0	Cc1ccc(N2CCN(CCCCC3C(=O)Nc4ccccc43)CC2)cc1	10.1021/acs.jmedchem.2c00633
		10379532	99275	0	None	1	6	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm030030n
		CHEMBL281923	99275	0	None	1	6	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm030030n
		10062885	99276	0	None	1	6	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm030030n
		CHEMBL281924	99276	0	None	1	6	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm030030n
		10062885	99276	0	None	1	6	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	291	1	0	2	3.7	CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1016/j.bmc.2020.115578
		CHEMBL281924	99276	0	None	1	6	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	291	1	0	2	3.7	CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1016/j.bmc.2020.115578
		10379532	99275	0	None	-1	6	Rat	9.0	pKi	=	9.0	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
		CHEMBL281923	99275	0	None	-1	6	Rat	9.0	pKi	=	9.0	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
		10062885	99276	0	None	-1	6	Rat	9.0	pKi	=	9.0	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
		CHEMBL281924	99276	0	None	-1	6	Rat	9.0	pKi	=	9.0	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
		24854044	97299	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(Cl)cc21	10.1021/jm200547z
		CHEMBL269083	97299	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(Cl)cc21	10.1021/jm200547z
		56944664	112073	0	None	23	4	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	428	8	1	6	3.0	Cc1cccc(S(=O)(=O)NCCCCN2CCN(c3noc4ccccc34)CC2)c1	10.1021/jm401895u
		CHEMBL3289968	112073	0	None	23	4	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	428	8	1	6	3.0	Cc1cccc(S(=O)(=O)NCCCCN2CCN(c3noc4ccccc34)CC2)c1	10.1021/jm401895u
		56944764	112096	0	None	3	4	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	417	6	1	5	3.4	Cc1cccc(S(=O)(=O)NCCN2CCC(c3noc4cc(F)ccc34)CC2)c1	10.1021/jm401895u
		CHEMBL3289990	112096	0	None	3	4	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	417	6	1	5	3.4	Cc1cccc(S(=O)(=O)NCCN2CCC(c3noc4cc(F)ccc34)CC2)c1	10.1021/jm401895u
		23643663	92844	0	None	13	3	Rat	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	447	9	1	3	5.7	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
		CHEMBL243744	92844	0	None	13	3	Rat	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	447	9	1	3	5.7	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
		145981875	166521	0	None	7	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	431	6	1	2	5.9	Fc1cccc(-c2ccccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.ejmech.2017.12.063
		CHEMBL4278933	166521	0	None	7	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	431	6	1	2	5.9	Fc1cccc(-c2ccccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.ejmech.2017.12.063
		145992877	166896	0	None	11	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	413	6	1	2	5.7	Fc1ccc2[nH]cc(CCCN3CCN(c4ccccc4-c4ccccc4)CC3)c2c1	10.1016/j.ejmech.2017.12.063
		CHEMBL4286174	166896	0	None	11	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	413	6	1	2	5.7	Fc1ccc2[nH]cc(CCCN3CCN(c4ccccc4-c4ccccc4)CC3)c2c1	10.1016/j.ejmech.2017.12.063
		3044582	192413	2	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)CC(N1CCN(C)CC1)c1ccccc1S2	10.1016/j.ejmech.2022.114218
		CHEMBL5208064	192413	2	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)CC(N1CCN(C)CC1)c1ccccc1S2	10.1016/j.ejmech.2022.114218
		11524003	159527	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	392	7	1	2	5.4	CCC1(CCCCN2CC=C(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		CHEMBL410225	159527	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	392	7	1	2	5.4	CCC1(CCCCN2CC=C(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		3233	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2009.06.038
		3247	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2009.06.038
		6604889	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2009.06.038
		CHEMBL282199	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2009.06.038
		DB13988	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2009.06.038
		3233	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2011.09.044
		3247	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2011.09.044
		6604889	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2011.09.044
		CHEMBL282199	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2011.09.044
		DB13988	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2011.09.044
		3233	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2012.07.043
		3247	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2012.07.043
		6604889	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2012.07.043
		CHEMBL282199	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2012.07.043
		DB13988	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2012.07.043
		118717211	120578	0	None	33	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	295	2	3	2	1.7	CCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
		CHEMBL3343663	120578	0	None	33	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	295	2	3	2	1.7	CCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
		CHEMBL3545801	120578	0	None	33	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	295	2	3	2	1.7	CCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
		11524003	159527	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	392	7	1	2	5.4	CCC1(CCCCN2CC=C(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
		CHEMBL410225	159527	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	392	7	1	2	5.4	CCC1(CCCCN2CC=C(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
		66801346	112099	0	None	1	4	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	485	7	1	5	4.8	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
		CHEMBL3289993	112099	0	None	1	4	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	485	7	1	5	4.8	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
		24854181	96432	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	425	8	1	3	5.3	CCC1(CCCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		CHEMBL262068	96432	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	425	8	1	3	5.3	CCC1(CCCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		3233	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2019.111705
		3247	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2019.111705
		6604889	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2019.111705
		CHEMBL282199	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2019.111705
		DB13988	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2019.111705
		3233	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/s0960-894x(02)00690-x
		3247	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/s0960-894x(02)00690-x
		6604889	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/s0960-894x(02)00690-x
		CHEMBL282199	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/s0960-894x(02)00690-x
		DB13988	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/s0960-894x(02)00690-x
		3233	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
		3247	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
		6604889	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
		CHEMBL282199	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
		DB13988	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
		3233	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030841r
		3247	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030841r
		6604889	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030841r
		CHEMBL282199	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030841r
		DB13988	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030841r
		3233	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.09.019
		3247	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.09.019
		6604889	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.09.019
		CHEMBL282199	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.09.019
		DB13988	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.09.019
		3233	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2013.02.038
		3247	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2013.02.038
		6604889	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2013.02.038
		CHEMBL282199	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2013.02.038
		DB13988	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2013.02.038
		3233	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.7b01898
		3247	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.7b01898
		6604889	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.7b01898
		CHEMBL282199	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.7b01898
		DB13988	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.7b01898
		3233	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2014.08.023
		3247	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2014.08.023
		6604889	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2014.08.023
		CHEMBL282199	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2014.08.023
		DB13988	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2014.08.023
		3233	3512	44	None	-2	12	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm0108505
		3247	3512	44	None	-2	12	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm0108505
		6604889	3512	44	None	-2	12	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm0108505
		CHEMBL282199	3512	44	None	-2	12	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm0108505
		DB13988	3512	44	None	-2	12	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm0108505
		24825775	1523	14	None	346	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
		3929	1523	14	None	346	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
		CHEMBL4205349	1523	14	None	346	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
		3233	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030030n
		3247	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030030n
		6604889	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030030n
		CHEMBL282199	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030030n
		DB13988	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030030n
		15803947	52354	1	None	13	4	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	161	3	0	2	2.1	CN(C)CCSC(C)(C)C	10.1016/j.bmcl.2003.11.050
		CHEMBL158973	52354	1	None	13	4	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	161	3	0	2	2.1	CN(C)CCSC(C)(C)C	10.1016/j.bmcl.2003.11.050
		24825775	1523	14	None	346	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
		3929	1523	14	None	346	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
		CHEMBL4205349	1523	14	None	346	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
		3233	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.09.019
		3247	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.09.019
		6604889	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.09.019
		CHEMBL282199	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.09.019
		DB13988	3512	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.09.019
		118717223	120582	0	None	7	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	321	1	2	2	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CCOCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		CHEMBL3343671	120582	0	None	7	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	321	1	2	2	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CCOCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		CHEMBL3545813	120582	0	None	7	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	321	1	2	2	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CCOCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		56944859	112108	0	None	-1	4	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	453	6	1	5	4.3	O=S(=O)(NCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12	10.1021/jm401895u
		CHEMBL3290001	112108	0	None	-1	4	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	453	6	1	5	4.3	O=S(=O)(NCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12	10.1021/jm401895u
		56944384	112121	0	None	-1	4	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	521	8	1	6	5.8	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
		CHEMBL3290014	112121	0	None	-1	4	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	521	8	1	6	5.8	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
		66801565	112127	0	None	7	3	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	474	7	1	7	4.1	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
		CHEMBL3290020	112127	0	None	7	3	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	474	7	1	7	4.1	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
		2389	3331	118	None	-7	67	Rat	8.9	pKi	=	8.9	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030030n
		5073	3331	118	None	-7	67	Rat	8.9	pKi	=	8.9	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030030n
		96	3331	118	None	-7	67	Rat	8.9	pKi	=	8.9	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030030n
		CHEMBL85	3331	118	None	-7	67	Rat	8.9	pKi	=	8.9	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030030n
		DB00734	3331	118	None	-7	67	Rat	8.9	pKi	=	8.9	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030030n
		60196080	81807	2	None	12	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	252	2	1	2	3.1	Cc1ccccc1-c1cccc(N2CCNCC2)c1	10.1021/jm3003679
		CHEMBL2164330	81807	2	None	12	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	252	2	1	2	3.1	Cc1ccccc1-c1cccc(N2CCNCC2)c1	10.1021/jm3003679
		2737389	187586	28	None	53	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	238	2	1	2	2.8	c1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
		CHEMBL494675	187586	28	None	53	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	238	2	1	2	2.8	c1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
		11637931	120583	0	None	2	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	295	2	2	2	2.0	COC1(C)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
		CHEMBL3343665	120583	0	None	2	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	295	2	2	2	2.0	COC1(C)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
		CHEMBL3545814	120583	0	None	2	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	295	2	2	2	2.0	COC1(C)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
		5	139	72	None	-3	54	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.04.034
		5202	139	72	None	-3	54	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.04.034
		CHEMBL39	139	72	None	-3	54	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.04.034
		DB08839	139	72	None	-3	54	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.04.034
		56944666	112113	0	None	-1	4	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	481	8	1	5	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
		CHEMBL3290006	112113	0	None	-1	4	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	481	8	1	5	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
		2737389	187586	28	None	53	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysis	ChEMBL	238	2	1	2	2.8	c1ccc(-c2ccccc2N2CCNCC2)cc1	10.1039/C8MD00313K
		CHEMBL494675	187586	28	None	53	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysis	ChEMBL	238	2	1	2	2.8	c1ccc(-c2ccccc2N2CCNCC2)cc1	10.1039/C8MD00313K
		162643494	181649	0	None	3	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	437	7	1	5	3.6	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)c(Cl)c1	10.1016/j.ejmech.2020.112149
		CHEMBL4775997	181649	0	None	3	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	437	7	1	5	3.6	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)c(Cl)c1	10.1016/j.ejmech.2020.112149
		24854111	95759	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	425	8	1	3	5.3	CCC1(CCCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		CHEMBL258496	95759	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	425	8	1	3	5.3	CCC1(CCCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		66801229	112057	0	None	-1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	452	6	1	6	3.6	O=S(=O)(NCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
		CHEMBL3289952	112057	0	None	-1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	452	6	1	6	3.6	O=S(=O)(NCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
		66800939	112058	0	None	1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	466	7	1	6	3.9	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
		CHEMBL3289953	112058	0	None	1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	466	7	1	6	3.9	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
		56944667	112098	0	None	1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	445	8	1	5	4.2	Cc1cccc(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)c1	10.1021/jm401895u
		CHEMBL3289992	112098	0	None	1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	445	8	1	5	4.2	Cc1cccc(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)c1	10.1021/jm401895u
		24854183	95902	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	413	7	1	3	4.6	CCC1(CCCCN2CCN(c3ccc(F)cc3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm070279v
		CHEMBL259216	95902	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	413	7	1	3	4.6	CCC1(CCCCN2CCN(c3ccc(F)cc3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm070279v
		CHEMBL5094234	215573	0	None	2	8	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		CHEMBL5096019	215573	0	None	2	8	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		134155116	150968	0	None	12	7	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	309	3	0	2	3.6	O=C1c2ccc(F)cc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
		CHEMBL3958215	150968	0	None	12	7	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	309	3	0	2	3.6	O=C1c2ccc(F)cc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
		CHEMBL5091373	215567	0	None	1	9	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		CHEMBL5095981	215567	0	None	1	9	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		134155116	150968	0	None	12	7	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	309	3	0	2	3.6	O=C1c2ccc(F)cc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
		CHEMBL3958215	150968	0	None	12	7	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	309	3	0	2	3.6	O=C1c2ccc(F)cc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
		132525570	163645	0	None	6	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranesDisplacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes	ChEMBL	300	5	0	5	2.8	CCCCc1cc(-c2ccoc2)nc(N2CCN(C)CC2)n1	10.1021/acs.jmedchem.7b01898
		CHEMBL4204059	163645	0	None	6	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranesDisplacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes	ChEMBL	300	5	0	5	2.8	CCCCc1cc(-c2ccoc2)nc(N2CCN(C)CC2)n1	10.1021/acs.jmedchem.7b01898
		56944565	112049	0	None	-3	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	444	8	1	6	3.5	Cc1cccc(S(=O)(=O)NCCCCN2CCN(c3nsc4ccccc34)CC2)c1	10.1021/jm401895u
		CHEMBL3289944	112049	0	None	-3	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	444	8	1	6	3.5	Cc1cccc(S(=O)(=O)NCCCCN2CCN(c3nsc4ccccc34)CC2)c1	10.1021/jm401895u
		56944383	112119	0	None	-3	12	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	487	8	1	6	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
		CHEMBL3290012	112119	0	None	-3	12	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	487	8	1	6	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
		44437330	152189	0	None	-	1	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	706	19	0	8	7.5	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		CHEMBL396844	152189	0	None	-	1	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	706	19	0	8	7.5	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		44266268	207797	0	None	10	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	394	5	0	3	3.8	O=C(c1ccc(F)cc1)C1CCN(CCN2CCCc3ccccc3C2=O)CC1	10.1016/s0960-894x(03)00077-5
		CHEMBL9616	207797	0	None	10	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	394	5	0	3	3.8	O=C(c1ccc(F)cc1)C1CCN(CCN2CCCc3ccccc3C2=O)CC1	10.1016/s0960-894x(03)00077-5
		162652285	180275	0	None	2	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	399	7	1	5	3.1	Cc1cccc(S(=O)(=O)N[C@@H]2CCN(CCCc3noc4ccccc34)C2)c1	10.1016/j.ejmech.2020.112149
		CHEMBL4750664	180275	0	None	2	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	399	7	1	5	3.1	Cc1cccc(S(=O)(=O)N[C@@H]2CCN(CCCc3noc4ccccc34)C2)c1	10.1016/j.ejmech.2020.112149
		162654074	180579	0	None	-3	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	435	7	1	5	4.0	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc2ccccc12	10.1016/j.ejmech.2020.112149
		CHEMBL4754138	180579	0	None	-3	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	435	7	1	5	4.0	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc2ccccc12	10.1016/j.ejmech.2020.112149
		11500509	120581	0	None	3	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		CHEMBL3343670	120581	0	None	3	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		CHEMBL3545812	120581	0	None	3	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		66801107	112046	0	None	-1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	430	7	1	6	3.1	Cc1cccc(S(=O)(=O)NCCCN2CCN(c3nsc4ccccc34)CC2)c1	10.1021/jm401895u
		CHEMBL3289709	112046	0	None	-1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	430	7	1	6	3.1	Cc1cccc(S(=O)(=O)NCCCN2CCN(c3nsc4ccccc34)CC2)c1	10.1021/jm401895u
		4106	2502	22	None	-4	34	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmcl.2018.04.059
		5358812	2502	22	None	-4	34	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmcl.2018.04.059
		89	2502	22	None	-4	34	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmcl.2018.04.059
		CHEMBL93240	2502	22	None	-4	34	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmcl.2018.04.059
		4106	2502	22	None	-4	34	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmc.2023.117256
		5358812	2502	22	None	-4	34	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmc.2023.117256
		89	2502	22	None	-4	34	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmc.2023.117256
		CHEMBL93240	2502	22	None	-4	34	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmc.2023.117256
		118713592	114378	0	None	3	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	401	6	0	5	4.3	O=c1sc2ccccc2n1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2014.08.023
		CHEMBL3331261	114378	0	None	3	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	401	6	0	5	4.3	O=c1sc2ccccc2n1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2014.08.023
		11187960	66230	0	None	6	2	Rat	8.8	pKi	=	8.8	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	337	7	0	2	5.3	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2OC)C1	10.1021/jm0498102
		CHEMBL184535	66230	0	None	6	2	Rat	8.8	pKi	=	8.8	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	337	7	0	2	5.3	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2OC)C1	10.1021/jm0498102
		44437329	151600	0	None	-8	2	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	692	18	0	8	7.1	COc1ccccc1N1CCN(CCc2cccc(OCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		CHEMBL396349	151600	0	None	-8	2	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	692	18	0	8	7.1	COc1ccccc1N1CCN(CCc2cccc(OCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		1809	134	32	None	-2	36	Rat	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm400766k
		4	134	32	None	-2	36	Rat	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm400766k
		CHEMBL18840	134	32	None	-2	36	Rat	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm400766k
		118717220	120580	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	305	1	2	1	2.9	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		CHEMBL3343669	120580	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	305	1	2	1	2.9	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		CHEMBL3545811	120580	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	305	1	2	1	2.9	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		56944564	112059	0	None	-2	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	480	8	1	6	4.3	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
		CHEMBL3289954	112059	0	None	-2	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	480	8	1	6	4.3	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
		24854185	157708	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	439	8	1	3	5.6	CC(C)CC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		CHEMBL408191	157708	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	439	8	1	3	5.6	CC(C)CC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		44340834	110225	0	None	169	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	494	6	1	6	4.0	O=c1oc2ccccc2n1C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/s0960-894x(02)00690-x
		CHEMBL323778	110225	0	None	169	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	494	6	1	6	4.0	O=c1oc2ccccc2n1C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/s0960-894x(02)00690-x
		155567938	176034	0	None	20	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	386	8	2	5	2.8	NC(=O)c1sccc1NC(=O)CCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2019.111690
		CHEMBL4590226	176034	0	None	20	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	386	8	2	5	2.8	NC(=O)c1sccc1NC(=O)CCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2019.111690
		10834268	166826	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	390	6	1	4	3.6	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3	10.1021/jm0104264
		CHEMBL428494	166826	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	390	6	1	4	3.6	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3	10.1021/jm0104264
		10834268	166826	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	390	6	1	4	3.6	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3	10.1021/jm980519u
		CHEMBL428494	166826	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	390	6	1	4	3.6	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3	10.1021/jm980519u
		168288462	191705	0	None	2	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	461	8	0	5	3.6	COc1ccccc1N1CCN(CCC[C@H]2CCCN2S(=O)(=O)c2ccccc2F)CC1	10.1021/acs.jmedchem.2c00633
		CHEMBL5196950	191705	0	None	2	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	461	8	0	5	3.6	COc1ccccc1N1CCN(CCC[C@H]2CCCN2S(=O)(=O)c2ccccc2F)CC1	10.1021/acs.jmedchem.2c00633
		60195993	81811	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	266	2	1	2	3.4	Cc1ccc(-c2ccccc2N2CCNCC2)cc1C	10.1021/jm3003679
		CHEMBL2164334	81811	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	266	2	1	2	3.4	Cc1ccc(-c2ccccc2N2CCNCC2)cc1C	10.1021/jm3003679
		3233	3512	44	None	2	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2019.111690
		3247	3512	44	None	2	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2019.111690
		6604889	3512	44	None	2	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2019.111690
		CHEMBL282199	3512	44	None	2	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2019.111690
		DB13988	3512	44	None	2	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2019.111690
		56944383	112119	0	None	-3	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells	ChEMBL	487	8	1	6	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
		CHEMBL3290012	112119	0	None	-3	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells	ChEMBL	487	8	1	6	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
		24854105	157933	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	401	6	1	3	4.5	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1021/jm070279v
		CHEMBL408450	157933	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	401	6	1	3	4.5	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1021/jm070279v
		155542678	173162	0	None	281	2	Human	8.7	pKi	=	8.7	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	487	7	1	4	4.9	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@H]1CCN1CCC(Oc2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2019.111705
		CHEMBL4521657	173162	0	None	281	2	Human	8.7	pKi	=	8.7	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	487	7	1	4	4.9	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@H]1CCN1CCC(Oc2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2019.111705
		10028436	3532	5	None	1	12	Rat	8.7	pKi	=	8.7	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/j.bmcl.2004.11.013
		3237	3532	5	None	1	12	Rat	8.7	pKi	=	8.7	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/j.bmcl.2004.11.013
		CHEMBL95104	3532	5	None	1	12	Rat	8.7	pKi	=	8.7	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/j.bmcl.2004.11.013
		44396223	123810	0	None	281	2	Rat	8.7	pKi	=	8.7	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	486	7	0	4	5.0	O=S(=O)(c1ccc2c(c1)CC=C2)N1CCC[C@@H]1CCN1CCC(Oc2ccc(Cl)cc2)CC1	10.1021/jm0498102
		CHEMBL362354	123810	0	None	281	2	Rat	8.7	pKi	=	8.7	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	486	7	0	4	5.0	O=S(=O)(c1ccc2c(c1)CC=C2)N1CCC[C@@H]1CCN1CCC(Oc2ccc(Cl)cc2)CC1	10.1021/jm0498102
		10573876	10462	0	None	199	7	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	414	5	0	3	3.7	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(Br)c2)CC1	10.1021/jm991151j
		CHEMBL116448	10462	0	None	199	7	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	414	5	0	3	3.7	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(Br)c2)CC1	10.1021/jm991151j
		8431	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm991151j
		9843179	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm991151j
		CHEMBL69257	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm991151j
		44368731	119691	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	414	5	0	3	3.7	CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc(Br)c2)CC1	10.1021/jm030841r
		CHEMBL347286	119691	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	414	5	0	3	3.7	CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc(Br)c2)CC1	10.1021/jm030841r
		11047374	18909	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	388	6	1	2	5.3	O=C1Nc2cccc3c2C1(CCCCN1CCC(c2ccccc2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
		CHEMBL12846	18909	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	388	6	1	2	5.3	O=C1Nc2cccc3c2C1(CCCCN1CCC(c2ccccc2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
		10834268	166826	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	390	6	1	4	3.6	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
		CHEMBL428494	166826	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	390	6	1	4	3.6	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
		8431	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm030841r
		9843179	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm030841r
		CHEMBL69257	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm030841r
		10834268	166826	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	390	6	1	4	3.6	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3	10.1021/jm030841r
		CHEMBL428494	166826	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	390	6	1	4	3.6	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3	10.1021/jm030841r
		10433930	51089	0	None	-1	5	Human	8.7	pKi	=	8.7	Binding	Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)	ChEMBL	449	5	2	5	3.9	COc1ccc(S(=O)(=O)Nc2cc(Cl)cc(Cl)c2Cl)cc1N1CCNCC1	10.1016/s0960-894x(00)00597-7
		CHEMBL157910	51089	0	None	-1	5	Human	8.7	pKi	=	8.7	Binding	Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)	ChEMBL	449	5	2	5	3.9	COc1ccc(S(=O)(=O)Nc2cc(Cl)cc(Cl)c2Cl)cc1N1CCNCC1	10.1016/s0960-894x(00)00597-7
		10028436	3532	5	None	-1	12	Human	8.7	pKi	=	8.7	Binding	Compound was tested for its binding affinity in 5-hydroxytryptamine 7 receptor (using human cloned receptors in HEK 293 and [3H]5-CT as a radioligand )Compound was tested for its binding affinity in 5-hydroxytryptamine 7 receptor (using human cloned receptors in HEK 293 and [3H]5-CT as a radioligand )	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/s0960-894x(02)00690-x
		3237	3532	5	None	-1	12	Human	8.7	pKi	=	8.7	Binding	Compound was tested for its binding affinity in 5-hydroxytryptamine 7 receptor (using human cloned receptors in HEK 293 and [3H]5-CT as a radioligand )Compound was tested for its binding affinity in 5-hydroxytryptamine 7 receptor (using human cloned receptors in HEK 293 and [3H]5-CT as a radioligand )	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/s0960-894x(02)00690-x
		CHEMBL95104	3532	5	None	-1	12	Human	8.7	pKi	=	8.7	Binding	Compound was tested for its binding affinity in 5-hydroxytryptamine 7 receptor (using human cloned receptors in HEK 293 and [3H]5-CT as a radioligand )Compound was tested for its binding affinity in 5-hydroxytryptamine 7 receptor (using human cloned receptors in HEK 293 and [3H]5-CT as a radioligand )	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/s0960-894x(02)00690-x
		46203758	124548	0	None	-	1	Rat	8.0	pKi	=	8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	339	5	1	4	3.6	COc1ccc(-c2ccccc2OC(F)(F)F)cc1OC1CNC1	nan
		CHEMBL3640556	124548	0	None	-	1	Rat	8.0	pKi	=	8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	339	5	1	4	3.6	COc1ccc(-c2ccccc2OC(F)(F)F)cc1OC1CNC1	nan
		44393072	169276	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	353	8	2	6	3.7	C[C@H](Nc1nc(F)nc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
		CHEMBL441312	169276	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	353	8	2	6	3.7	C[C@H](Nc1nc(F)nc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
		2389	3331	118	None	-8	67	Human	8.0	pKi	=	8	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		5073	3331	118	None	-8	67	Human	8.0	pKi	=	8	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		96	3331	118	None	-8	67	Human	8.0	pKi	=	8	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		CHEMBL85	3331	118	None	-8	67	Human	8.0	pKi	=	8	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		DB00734	3331	118	None	-8	67	Human	8.0	pKi	=	8	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		10171	56	18	None	-5	6	Rat	8.0	pKi	=	8	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1016/s0960-894x(00)00166-9
		272	56	18	None	-5	6	Rat	8.0	pKi	=	8	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1016/s0960-894x(00)00166-9
		CHEMBL274384	56	18	None	-5	6	Rat	8.0	pKi	=	8	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1016/s0960-894x(00)00166-9
		10499156	114091	1	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	366	6	0	4	3.0	COc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/jm991151j
		CHEMBL332701	114091	1	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	366	6	0	4	3.0	COc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/jm991151j
		10249573	207593	0	None	1	11	Human	8.0	pKi	=	8	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
		CHEMBL94984	207593	0	None	1	11	Human	8.0	pKi	=	8	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
		44368705	45868	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	366	6	0	4	3.0	COc1cccc(S(=O)(=O)N2CCC[C@H]2CCN2CCC(C)CC2)c1	10.1021/jm030841r
		CHEMBL153156	45868	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	366	6	0	4	3.0	COc1cccc(S(=O)(=O)N2CCC[C@H]2CCN2CCC(C)CC2)c1	10.1021/jm030841r
		10596321	207464	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm030841r
		CHEMBL94261	207464	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm030841r
		44460708	205608	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	331	3	0	3	3.9	Clc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1021/jm030030n
		CHEMBL81607	205608	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	331	3	0	3	3.9	Clc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1021/jm030030n
		10249573	207593	0	None	1	11	Human	8.0	pKi	=	8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm030030n
		CHEMBL94984	207593	0	None	1	11	Human	8.0	pKi	=	8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm030030n
		44461065	205544	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	389	4	0	3	4.4	Brc1ccc2ccn(CCN3CCCN(C4CCCC4)CC3)c2c1	10.1016/s0960-894x(02)00438-9
		CHEMBL81022	205544	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	389	4	0	3	4.4	Brc1ccc2ccn(CCN3CCCN(C4CCCC4)CC3)c2c1	10.1016/s0960-894x(02)00438-9
		44460708	205608	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	331	3	0	3	3.9	Clc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1016/s0960-894x(02)00438-9
		CHEMBL81607	205608	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	331	3	0	3	3.9	Clc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1016/s0960-894x(02)00438-9
		10249573	207593	0	None	-1	11	Rat	8.0	pKi	=	8	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm049743b
		CHEMBL94984	207593	0	None	-1	11	Rat	8.0	pKi	=	8	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm049743b
		5	139	72	None	-5	54	Rat	8.0	pKi	=	8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
		5202	139	72	None	-5	54	Rat	8.0	pKi	=	8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
		CHEMBL39	139	72	None	-5	54	Rat	8.0	pKi	=	8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
		DB08839	139	72	None	-5	54	Rat	8.0	pKi	=	8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
		9894665	103813	1	None	-30	8	Human	8.0	pKi	=	8	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	ChEMBL	585	10	2	8	3.3	CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(N(C)C)cc2)C3=O)CC1	10.1021/jm9905918
		CHEMBL309106	103813	1	None	-30	8	Human	8.0	pKi	=	8	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	ChEMBL	585	10	2	8	3.3	CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(N(C)C)cc2)C3=O)CC1	10.1021/jm9905918
		46203758	124548	0	None	-	1	Rat	8.0	pKi	=	8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	339	5	1	4	3.6	COc1ccc(-c2ccccc2OC(F)(F)F)cc1OC1CNC1	nan
		CHEMBL3640556	124548	0	None	-	1	Rat	8.0	pKi	=	8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	339	5	1	4	3.6	COc1ccc(-c2ccccc2OC(F)(F)F)cc1OC1CNC1	nan
		CHEMBL5074880	214339	0	None	1	9	Human	8.0	pKi	=	8	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		127028472	138171	0	None	9	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	470	8	2	6	2.2	CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2016.02.024
		CHEMBL3769534	138171	0	None	9	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	470	8	2	6	2.2	CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2016.02.024
		127038281	137087	0	None	1	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	494	10	0	6	4.0	Cn1cc(S(=O)(=O)N(CC2CC2)C2CCN(CCOc3ccccc3-c3ccccc3)CC2)cn1	10.1016/j.bmc.2015.11.041
		CHEMBL3747240	137087	0	None	1	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	494	10	0	6	4.0	Cn1cc(S(=O)(=O)N(CC2CC2)C2CCN(CCOc3ccccc3-c3ccccc3)CC2)cn1	10.1016/j.bmc.2015.11.041
		127041259	137098	0	None	4	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	420	8	0	6	2.7	CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2cnn(C)c2)CC1	10.1016/j.bmc.2015.11.041
		CHEMBL3747459	137098	0	None	4	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	420	8	0	6	2.7	CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2cnn(C)c2)CC1	10.1016/j.bmc.2015.11.041
		145985505	165625	0	None	-3	5	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	491	6	0	7	3.7	O=S(=O)(c1cccc2cnccc12)N1CCC[C@H]1CCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4243579	165625	0	None	-3	5	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	491	6	0	7	3.7	O=S(=O)(c1cccc2cnccc12)N1CCC[C@H]1CCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
		134145903	148878	0	None	5	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	455	10	1	3	5.9	C[C@H](NC(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)c1ccccc1	10.1016/j.ejmech.2016.05.005
		CHEMBL3941529	148878	0	None	5	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	455	10	1	3	5.9	C[C@H](NC(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)c1ccccc1	10.1016/j.ejmech.2016.05.005
		71456781	81428	0	None	1	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	8	1	5	3.8	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1cccs1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159471	81428	0	None	1	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	8	1	5	3.8	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1cccs1	10.1016/j.ejmech.2012.07.043
		71458651	81434	0	None	1	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	439	8	1	5	3.8	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc3cccnc23)C1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159477	81434	0	None	1	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	439	8	1	5	3.8	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc3cccnc23)C1	10.1016/j.ejmech.2012.07.043
		71456784	81449	0	None	1	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	440	8	1	4	3.9	O=S(=O)(N[C@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159492	81449	0	None	1	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	440	8	1	4	3.9	O=S(=O)(N[C@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
		242	470	124	None	-15	51	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2022.114193
		34	470	124	None	-15	51	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2022.114193
		60795	470	124	None	-15	51	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2022.114193
		CHEMBL1112	470	124	None	-15	51	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2022.114193
		DB01238	470	124	None	-15	51	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2022.114193
		118731352	118189	0	None	2	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	510	9	1	4	4.5	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
		CHEMBL3409036	118189	0	None	2	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	510	9	1	4	4.5	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
		118731362	118198	0	None	4	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	564	8	0	4	5.6	O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
		CHEMBL3409045	118198	0	None	4	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	564	8	0	4	5.6	O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
		145947590	167705	0	None	8	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	516	7	2	6	2.4	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(Br)cc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
		CHEMBL4170657	167705	0	None	8	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	516	7	2	6	2.4	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(Br)cc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
		CHEMBL4302436	167705	0	None	8	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	516	7	2	6	2.4	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(Br)cc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
		145947976	167714	0	None	41	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	438	7	2	6	1.6	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
		CHEMBL4168743	167714	0	None	41	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	438	7	2	6	1.6	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
		CHEMBL4302539	167714	0	None	41	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	438	7	2	6	1.6	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
		56944952	157367	0	None	-2	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	447	7	2	3	4.4	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(F)cc1	10.1021/acs.jmedchem.7b00839
		CHEMBL4077937	157367	0	None	-2	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	447	7	2	3	4.4	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(F)cc1	10.1021/acs.jmedchem.7b00839
		24854103	96155	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)c(Cl)cc21	10.1021/jm200547z
		CHEMBL260551	96155	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)c(Cl)cc21	10.1021/jm200547z
		127052458	140740	0	None	3	7	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	5	1	3	3.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818056	140740	0	None	3	7	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	5	1	3	3.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1	10.1016/j.bmc.2016.05.053
		90644074	112072	0	None	151	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	414	7	1	6	2.6	Cc1cccc(S(=O)(=O)NCCCN2CCN(c3noc4ccccc34)CC2)c1	10.1021/jm401895u
		CHEMBL3289967	112072	0	None	151	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	414	7	1	6	2.6	Cc1cccc(S(=O)(=O)NCCCN2CCN(c3noc4ccccc34)CC2)c1	10.1021/jm401895u
		56943695	112122	0	None	-4	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	505	7	1	6	5.2	Cc1c(S(=O)(=O)NCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
		CHEMBL3290015	112122	0	None	-4	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	505	7	1	6	5.2	Cc1c(S(=O)(=O)NCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
		10171	56	18	None	-11	6	Human	8.0	pKi	=	8	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1021/jm030841r
		272	56	18	None	-11	6	Human	8.0	pKi	=	8	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1021/jm030841r
		CHEMBL274384	56	18	None	-11	6	Human	8.0	pKi	=	8	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1021/jm030841r
		90656682	110978	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	311	6	2	4	3.0	Oc1cccc(NCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262411	110978	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	311	6	2	4	3.0	Oc1cccc(NCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
		11525867	96226	1	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	479	7	1	3	6.2	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c(Cl)cc(Cl)cc21	10.1021/jm070279v
		CHEMBL260870	96226	1	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	479	7	1	3	6.2	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c(Cl)cc(Cl)cc21	10.1021/jm070279v
		44266289	98163	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	404	4	1	5	3.5	O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3ccccc32)CC1	10.1016/s0960-894x(03)00077-5
		CHEMBL273872	98163	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	404	4	1	5	3.5	O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3ccccc32)CC1	10.1016/s0960-894x(03)00077-5
		127052458	140740	0	None	3	7	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	5	1	3	3.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818056	140740	0	None	3	7	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	5	1	3	3.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1	10.1016/j.bmc.2016.05.053
		242	470	124	None	-15	51	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113243
		34	470	124	None	-15	51	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113243
		60795	470	124	None	-15	51	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113243
		CHEMBL1112	470	124	None	-15	51	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113243
		DB01238	470	124	None	-15	51	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113243
		242	470	124	None	-15	51	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2020.115943
		34	470	124	None	-15	51	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2020.115943
		60795	470	124	None	-15	51	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2020.115943
		CHEMBL1112	470	124	None	-15	51	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2020.115943
		DB01238	470	124	None	-15	51	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2020.115943
		242	470	124	None	-15	51	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
		34	470	124	None	-15	51	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
		60795	470	124	None	-15	51	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
		CHEMBL1112	470	124	None	-15	51	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
		DB01238	470	124	None	-15	51	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
		10714877	114372	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	381	7	0	6	3.2	COc1ccccc1N1CCN(CCCCn2c(=O)oc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
		CHEMBL3331256	114372	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	381	7	0	6	3.2	COc1ccccc1N1CCN(CCCCn2c(=O)oc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
		11825614	102610	1	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	403	6	1	3	4.5	Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
		CHEMBL304167	102610	1	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	403	6	1	3	4.5	Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
		46204726	124567	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	327	3	1	2	4.4	FC(F)(F)c1ccccc1-c1ccc(Cl)c(OC2CNC2)c1	nan
		CHEMBL3640574	124567	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	327	3	1	2	4.4	FC(F)(F)c1ccccc1-c1ccc(Cl)c(OC2CNC2)c1	nan
		46204726	124567	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	327	3	1	2	4.4	FC(F)(F)c1ccccc1-c1ccc(Cl)c(OC2CNC2)c1	nan
		CHEMBL3640574	124567	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	327	3	1	2	4.4	FC(F)(F)c1ccccc1-c1ccc(Cl)c(OC2CNC2)c1	nan
		134155476	151225	0	None	7	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	455	10	1	3	5.9	C[C@@H](NC(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)c1ccccc1	10.1016/j.ejmech.2016.05.005
		CHEMBL3960056	151225	0	None	7	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	455	10	1	3	5.9	C[C@@H](NC(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)c1ccccc1	10.1016/j.ejmech.2016.05.005
		2726	919	68	None	-13	72	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2013.02.038
		621	919	68	None	-13	72	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2013.02.038
		83	919	68	None	-13	72	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2013.02.038
		CHEMBL71	919	68	None	-13	72	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2013.02.038
		DB00477	919	68	None	-13	72	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2013.02.038
		76336186	106402	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	397	5	0	4	5.0	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
		CHEMBL3121435	106402	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	397	5	0	4	5.0	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
		CHEMBL3139448	106402	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	397	5	0	4	5.0	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
		11667458	65999	0	None	5	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	350	6	1	4	3.1	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccccn2)CC1	10.1021/jm200547z
		CHEMBL1836788	65999	0	None	5	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	350	6	1	4	3.1	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccccn2)CC1	10.1021/jm200547z
		11407754	98181	0	None	-	1	Rat	7.0	pKi	=	7	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	429	8	0	4	4.8	COc1ccccc1N1CCN(CCCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1016/s0960-894x(00)00166-9
		CHEMBL273982	98181	0	None	-	1	Rat	7.0	pKi	=	7	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	429	8	0	4	4.8	COc1ccccc1N1CCN(CCCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1016/s0960-894x(00)00166-9
		49850870	56389	0	None	-794	9	Human	7.0	pKi	=	7	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	424	6	1	5	3.3	Cc1ccc2c(N3CCN(CCc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1631535	56389	0	None	-794	9	Human	7.0	pKi	=	7	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	424	6	1	5	3.3	Cc1ccc2c(N3CCN(CCc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1	10.1021/jm100714c
		242	470	124	None	-15	51	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		34	470	124	None	-15	51	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		60795	470	124	None	-15	51	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		CHEMBL1112	470	124	None	-15	51	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		DB01238	470	124	None	-15	51	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		135398737	958	93	None	-13	89	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		38	958	93	None	-13	89	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		722	958	93	None	-13	89	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		CHEMBL42	958	93	None	-13	89	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		DB00363	958	93	None	-13	89	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		11407754	98181	0	None	-	1	Rat	7.0	pKi	=	7	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	429	8	0	4	4.8	COc1ccccc1N1CCN(CCCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1021/jm030841r
		CHEMBL273982	98181	0	None	-	1	Rat	7.0	pKi	=	7	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	429	8	0	4	4.8	COc1ccccc1N1CCN(CCCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1021/jm030841r
		44374234	55555	0	None	12	2	Human	7.0	pKi	=	7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1ccnc(-c2ccccc2)c1	10.1016/j.bmcl.2003.11.050
		CHEMBL162071	55555	0	None	12	2	Human	7.0	pKi	=	7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1ccnc(-c2ccccc2)c1	10.1016/j.bmcl.2003.11.050
		10737314	97271	0	None	-	1	Human	7.0	pKi	=	7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	361	4	1	3	3.4	O=C1Nc2cccc3c2C1(CCN1CCN(c2ccccc2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
		CHEMBL268921	97271	0	None	-	1	Human	7.0	pKi	=	7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	361	4	1	3	3.4	O=C1Nc2cccc3c2C1(CCN1CCN(c2ccccc2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
		10737314	97271	0	None	-	1	Human	7.0	pKi	=	7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	361	4	1	3	3.4	O=C1Nc2cccc3c2C1(CCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm030841r
		CHEMBL268921	97271	0	None	-	1	Human	7.0	pKi	=	7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	361	4	1	3	3.4	O=C1Nc2cccc3c2C1(CCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm030841r
		11166042	166369	0	None	-2	3	Rat	7.0	pKi	=	7	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	419	9	1	6	2.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1021/jm049743b
		CHEMBL427518	166369	0	None	-2	3	Rat	7.0	pKi	=	7	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	419	9	1	6	2.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1021/jm049743b
		135	2532	43	None	-50	58	Rat	7.0	pKi	=	7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030030n
		1796	2532	43	None	-50	58	Rat	7.0	pKi	=	7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030030n
		4184	2532	43	None	-50	58	Rat	7.0	pKi	=	7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030030n
		CHEMBL6437	2532	43	None	-50	58	Rat	7.0	pKi	=	7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030030n
		DB06148	2532	43	None	-50	58	Rat	7.0	pKi	=	7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030030n
		CHEMBL5071978	214272	0	None	-1	6	Human	7.0	pKi	=	7	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCN(CC)Cc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		127041874	137047	0	None	-2	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	450	8	0	4	4.5	CN(C1CCN(CCOc2ccccc2-c2ccccc2)CC1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2015.11.041
		CHEMBL3746713	137047	0	None	-2	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	450	8	0	4	4.5	CN(C1CCN(CCOc2ccccc2-c2ccccc2)CC1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2015.11.041
		145975905	163828	0	None	5	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	376	4	1	4	2.4	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccccc3)CC1)C2	10.1016/j.bmcl.2018.06.019
		CHEMBL4206366	163828	0	None	5	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	376	4	1	4	2.4	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccccc3)CC1)C2	10.1016/j.bmcl.2018.06.019
		11414582	181338	0	None	-16	4	Rat	7.0	pKi	=	7	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	271	2	1	3	2.7	Fc1ccc(-c2c3c(nn2C2CC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
		CHEMBL4762886	181338	0	None	-16	4	Rat	7.0	pKi	=	7	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	271	2	1	3	2.7	Fc1ccc(-c2c3c(nn2C2CC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
		2470	3653	50	None	-1258	59	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.ejmech.2019.111705
		3300	3653	50	None	-1258	59	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.ejmech.2019.111705
		5265	3653	50	None	-1258	59	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.ejmech.2019.111705
		99	3653	50	None	-1258	59	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.ejmech.2019.111705
		CHEMBL267930	3653	50	None	-1258	59	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.ejmech.2019.111705
		44439409	91216	0	None	15	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	322	5	0	3	4.0	CC(=O)OC1CCc2ccc(/N=C/N(C)Cc3ccccc3)cc21	10.1016/j.bmcl.2007.01.093
		CHEMBL240025	91216	0	None	15	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	322	5	0	3	4.0	CC(=O)OC1CCc2ccc(/N=C/N(C)Cc3ccccc3)cc21	10.1016/j.bmcl.2007.01.093
		44439404	91785	0	None	15	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	334	3	0	3	4.0	CC(=O)OC1CCc2ccc(/N=C/N3CCc4ccccc4C3)cc21	10.1016/j.bmcl.2007.01.093
		CHEMBL241103	91785	0	None	15	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	334	3	0	3	4.0	CC(=O)OC1CCc2ccc(/N=C/N3CCc4ccccc4C3)cc21	10.1016/j.bmcl.2007.01.093
		21509921	104458	0	None	-9	24	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.7	CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1	10.1016/j.bmcl.2013.12.024
		CHEMBL3104091	104458	0	None	-9	24	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.7	CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1	10.1016/j.bmcl.2013.12.024
		11808247	18075	0	None	-1	9	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	285	5	0	2	3.7	Fc1ccc(OCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL126667	18075	0	None	-1	9	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	285	5	0	2	3.7	Fc1ccc(OCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3819366	18075	0	None	-1	9	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	285	5	0	2	3.7	Fc1ccc(OCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		9888211	21416	13	None	-125	10	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	417	6	1	3	4.5	O=C1c2ccccc2C(=O)N1CCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1	10.1021/jm070516u
		CHEMBL131495	21416	13	None	-125	10	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	417	6	1	3	4.5	O=C1c2ccccc2C(=O)N1CCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1	10.1021/jm070516u
		10317515	99759	2	None	-19	3	Rat	7.0	pKi	=	7	Binding	Binding affinity towards 5-HT 7 receptor in rat hypothalamus membranes using [3H]5-CT as radioligandBinding affinity towards 5-HT 7 receptor in rat hypothalamus membranes using [3H]5-CT as radioligand	ChEMBL	378	3	0	4	1.8	O=C1C2CCCN2C(=O)CN1CN1CCN(c2cccc3ccccc23)CC1	10.1016/s0960-894x(03)00160-4
		CHEMBL285066	99759	2	None	-19	3	Rat	7.0	pKi	=	7	Binding	Binding affinity towards 5-HT 7 receptor in rat hypothalamus membranes using [3H]5-CT as radioligandBinding affinity towards 5-HT 7 receptor in rat hypothalamus membranes using [3H]5-CT as radioligand	ChEMBL	378	3	0	4	1.8	O=C1C2CCCN2C(=O)CN1CN1CCN(c2cccc3ccccc23)CC1	10.1016/s0960-894x(03)00160-4
		46204086	124555	0	None	-	1	Rat	6.0	pKi	=	6	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2cccc(C)c2)cc1OC1CNC1	nan
		CHEMBL3640562	124555	0	None	-	1	Rat	6.0	pKi	=	6	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2cccc(C)c2)cc1OC1CNC1	nan
		11327643	119582	0	None	1	2	Human	6.0	pKi	=	6	Binding	Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)	ChEMBL	421	6	0	4	4.0	O=S1(=O)c2cccc3cccc(c23)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL346191	119582	0	None	1	2	Human	6.0	pKi	=	6	Binding	Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)	ChEMBL	421	6	0	4	4.0	O=S1(=O)c2cccc3cccc(c23)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2019.06.028
		240	944	43	None	-199	24	Human	6.0	pKi	=	6	Binding	Binding affinity to human serotonin 5-HT7 receptorBinding affinity to human serotonin 5-HT7 receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
		2769	944	43	None	-199	24	Human	6.0	pKi	=	6	Binding	Binding affinity to human serotonin 5-HT7 receptorBinding affinity to human serotonin 5-HT7 receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
		44279790	944	43	None	-199	24	Human	6.0	pKi	=	6	Binding	Binding affinity to human serotonin 5-HT7 receptorBinding affinity to human serotonin 5-HT7 receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
		660	944	43	None	-199	24	Human	6.0	pKi	=	6	Binding	Binding affinity to human serotonin 5-HT7 receptorBinding affinity to human serotonin 5-HT7 receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
		CHEMBL1729	944	43	None	-199	24	Human	6.0	pKi	=	6	Binding	Binding affinity to human serotonin 5-HT7 receptorBinding affinity to human serotonin 5-HT7 receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
		CHEMBL560739	944	43	None	-199	24	Human	6.0	pKi	=	6	Binding	Binding affinity to human serotonin 5-HT7 receptorBinding affinity to human serotonin 5-HT7 receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
		DB00604	944	43	None	-199	24	Human	6.0	pKi	=	6	Binding	Binding affinity to human serotonin 5-HT7 receptorBinding affinity to human serotonin 5-HT7 receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
		135398745	2914	112	None	-95	65	Human	6.0	pKi	=	6	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
		47	2914	112	None	-95	65	Human	6.0	pKi	=	6	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
		CHEMBL715	2914	112	None	-95	65	Human	6.0	pKi	=	6	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
		DB00334	2914	112	None	-95	65	Human	6.0	pKi	=	6	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
		2337	3256	77	None	-28	62	Human	6.0	pKi	=	6	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
		50	3256	77	None	-28	62	Human	6.0	pKi	=	6	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
		5002	3256	77	None	-28	62	Human	6.0	pKi	=	6	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
		CHEMBL716	3256	77	None	-28	62	Human	6.0	pKi	=	6	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
		DB01224	3256	77	None	-28	62	Human	6.0	pKi	=	6	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
		11327643	119582	0	None	-1	2	Rat	6.0	pKi	=	6	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	421	6	0	4	4.0	O=S1(=O)c2cccc3cccc(c23)N1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm030841r
		CHEMBL346191	119582	0	None	-1	2	Rat	6.0	pKi	=	6	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	421	6	0	4	4.0	O=S1(=O)c2cccc3cccc(c23)N1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm030841r
		9827938	11771	0	None	-39	12	Human	6.0	pKi	=	6	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT	ChEMBL	517	13	1	3	6.3	CN(C)CCN(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)C(=O)/C=C/c1ccccc1	10.1016/j.bmcl.2005.06.024
		CHEMBL1181680	11771	0	None	-39	12	Human	6.0	pKi	=	6	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT	ChEMBL	517	13	1	3	6.3	CN(C)CCN(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)C(=O)/C=C/c1ccccc1	10.1016/j.bmcl.2005.06.024
		CHEMBL188486	11771	0	None	-39	12	Human	6.0	pKi	=	6	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT	ChEMBL	517	13	1	3	6.3	CN(C)CCN(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)C(=O)/C=C/c1ccccc1	10.1016/j.bmcl.2005.06.024
		46204086	124555	0	None	-	1	Rat	6.0	pKi	=	6	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2cccc(C)c2)cc1OC1CNC1	nan
		CHEMBL3640562	124555	0	None	-	1	Rat	6.0	pKi	=	6	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2cccc(C)c2)cc1OC1CNC1	nan
		10125797	161811	9	None	-407	4	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@H]1CCc2cccc(O)c2C1	10.1016/j.bmc.2019.115262
		CHEMBL41436	161811	9	None	-407	4	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@H]1CCc2cccc(O)c2C1	10.1016/j.bmc.2019.115262
		CHEMBL541621	161811	9	None	-407	4	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@H]1CCc2cccc(O)c2C1	10.1016/j.bmc.2019.115262
		153287574	175247	0	None	-13	10	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	266	2	1	2	4.0	CC[C@H]1c2ccccc2N(c2ccccc2)C[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
		CHEMBL4572167	175247	0	None	-13	10	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	266	2	1	2	4.0	CC[C@H]1c2ccccc2N(c2ccccc2)C[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
		146709966	175779	0	None	-338	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2ccc3ccccc3c2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
		CHEMBL4583909	175779	0	None	-338	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2ccc3ccccc3c2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
		153287539	176074	0	None	-3	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	265	1	1	2	3.6	C[C@@]12COc3ccc(-c4ccccc4)cc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
		CHEMBL4591008	176074	0	None	-3	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	265	1	1	2	3.6	C[C@@]12COc3ccc(-c4ccccc4)cc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
		2543	3707	68	None	-93	32	Human	6.0	pKi	=	6	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/j.ejmech.2019.111705
		5358	3707	68	None	-93	32	Human	6.0	pKi	=	6	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/j.ejmech.2019.111705
		54	3707	68	None	-93	32	Human	6.0	pKi	=	6	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/j.ejmech.2019.111705
		CHEMBL128	3707	68	None	-93	32	Human	6.0	pKi	=	6	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/j.ejmech.2019.111705
		DB00669	3707	68	None	-93	32	Human	6.0	pKi	=	6	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/j.ejmech.2019.111705
		44439403	91784	0	None	-5	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	394	5	0	5	4.0	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(OC(C)=O)CC3)CC2	10.1016/j.bmcl.2007.01.093
		CHEMBL241102	91784	0	None	-5	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	394	5	0	5	4.0	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(OC(C)=O)CC3)CC2	10.1016/j.bmcl.2007.01.093
		76524414	140869	0	None	-77	8	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	426	6	1	4	5.8	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
		CHEMBL3819434	140869	0	None	-77	8	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	426	6	1	4	5.8	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
		CHEMBL3819713	140869	0	None	-77	8	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	426	6	1	4	5.8	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
		9913554	100992	0	None	-1258	14	Human	6.0	pKi	=	6	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand	ChEMBL	491	5	1	6	5.0	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1	10.1016/s0960-894x(02)00172-5
		CHEMBL29433	100992	0	None	-1258	14	Human	6.0	pKi	=	6	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand	ChEMBL	491	5	1	6	5.0	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1	10.1016/s0960-894x(02)00172-5
		46204732	124571	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	250	3	1	3	2.6	N#Cc1ccc(-c2ccccc2)cc1OC1CNC1	nan
		CHEMBL3640578	124571	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	250	3	1	3	2.6	N#Cc1ccc(-c2ccccc2)cc1OC1CNC1	nan
		46204734	124574	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	264	3	1	3	2.9	Cc1cc(C#N)c(OC2CNC2)cc1-c1ccccc1	nan
		CHEMBL3640580	124574	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	264	3	1	3	2.9	Cc1cc(C#N)c(OC2CNC2)cc1-c1ccccc1	nan
		46205044	124579	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	297	5	1	3	3.8	Cc1ccccc1-c1ccc(OC(C)C)c(OC2CNC2)c1	nan
		CHEMBL3640585	124579	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	297	5	1	3	3.8	Cc1ccccc1-c1ccc(OC(C)C)c(OC2CNC2)c1	nan
		10668422	98165	0	None	-	1	Human	5.0	pKi	=	5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	395	6	1	3	4.3	O=C1Nc2cccc3c2C1(CCCCN1CCN(C2CCCCC2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
		CHEMBL273890	98165	0	None	-	1	Human	5.0	pKi	=	5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	395	6	1	3	4.3	O=C1Nc2cccc3c2C1(CCCCN1CCN(C2CCCCC2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
		10643153	98523	0	None	-	1	Human	5.0	pKi	=	5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	C[C@H]1CCCN(CC[C@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1016/s0960-894x(00)00166-9
		CHEMBL276255	98523	0	None	-	1	Human	5.0	pKi	=	5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	C[C@H]1CCCN(CC[C@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1016/s0960-894x(00)00166-9
		46204732	124571	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	250	3	1	3	2.6	N#Cc1ccc(-c2ccccc2)cc1OC1CNC1	nan
		CHEMBL3640578	124571	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	250	3	1	3	2.6	N#Cc1ccc(-c2ccccc2)cc1OC1CNC1	nan
		46204734	124574	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	264	3	1	3	2.9	Cc1cc(C#N)c(OC2CNC2)cc1-c1ccccc1	nan
		CHEMBL3640580	124574	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	264	3	1	3	2.9	Cc1cc(C#N)c(OC2CNC2)cc1-c1ccccc1	nan
		46205044	124579	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	297	5	1	3	3.8	Cc1ccccc1-c1ccc(OC(C)C)c(OC2CNC2)c1	nan
		CHEMBL3640585	124579	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	297	5	1	3	3.8	Cc1ccccc1-c1ccc(OC(C)C)c(OC2CNC2)c1	nan
		13149	2545	36	None	-165	17	Human	5.0	pKi	=	5	Binding	Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay	ChEMBL	398	5	1	5	3.8	CC[C@@H]1CN2CCC3=C([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)NC4=C3C(=CC=C4)OC	10.1021/acs.jmedchem.1c00726
		3034396	2545	36	None	-165	17	Human	5.0	pKi	=	5	Binding	Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay	ChEMBL	398	5	1	5	3.8	CC[C@@H]1CN2CCC3=C([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)NC4=C3C(=CC=C4)OC	10.1021/acs.jmedchem.1c00726
		CHEMBL299031	2545	36	None	-165	17	Human	5.0	pKi	=	5	Binding	Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay	ChEMBL	398	5	1	5	3.8	CC[C@@H]1CN2CCC3=C([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)NC4=C3C(=CC=C4)OC	10.1021/acs.jmedchem.1c00726
		11462900	57010	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	372	4	1	3	4.7	FC(F)(F)Oc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
		CHEMBL1644270	57010	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	372	4	1	3	4.7	FC(F)(F)Oc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
		53316608	57016	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	344	3	1	2	5.1	CC(C)(C)c1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
		CHEMBL1644276	57016	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	344	3	1	2	5.1	CC(C)(C)c1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
		53316609	57017	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	322	3	1	2	4.5	Clc1cccc(-c2cn(Cc3ccccc3)c3c2CNCC3)c1	10.1016/j.bmcl.2010.11.078
		CHEMBL1644277	57017	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	322	3	1	2	4.5	Clc1cccc(-c2cn(Cc3ccccc3)c3c2CNCC3)c1	10.1016/j.bmcl.2010.11.078
		11449570	57021	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	304	3	2	3	3.6	Oc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
		CHEMBL1644281	57021	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	304	3	2	3	3.6	Oc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
		3251	4072	58	None	-33113	12	Human	5.0	pKi	=	5	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm1009956
		5684	4072	58	None	-33113	12	Human	5.0	pKi	=	5	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm1009956
		80	4072	58	None	-33113	12	Human	5.0	pKi	=	5	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm1009956
		CHEMBL31354	4072	58	None	-33113	12	Human	5.0	pKi	=	5	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm1009956
		44368373	119558	0	None	-	1	Human	4.0	pKi	=	4	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	373	6	0	3	4.8	CC([C@@H](C)CCN1CCC[C@H](C)C1)S(=O)(=O)c1cccc2ccccc12	10.1021/jm030841r
		CHEMBL345971	119558	0	None	-	1	Human	4.0	pKi	=	4	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	373	6	0	3	4.8	CC([C@@H](C)CCN1CCC[C@H](C)C1)S(=O)(=O)c1cccc2ccccc12	10.1021/jm030841r
		10668422	98165	0	None	-	1	Human	4.0	pKi	=	4	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	395	6	1	3	4.3	O=C1Nc2cccc3c2C1(CCCCN1CCN(C2CCCCC2)CC1)CCC3	10.1021/jm030841r
		CHEMBL273890	98165	0	None	-	1	Human	4.0	pKi	=	4	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	395	6	1	3	4.3	O=C1Nc2cccc3c2C1(CCCCN1CCN(C2CCCCC2)CC1)CCC3	10.1021/jm030841r
		CHEMBL5282788	194172	0	None	-1	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis	ChEMBL	422	7	0	5	3.5	O=C1CC2Cc3ccsc3C2=NN1CCCCN1CCN(Cc2ccccc2)CC1	10.1016/j.bmc.2023.117256
		76524414	140869	0	None	-77	8	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	426	6	1	4	5.8	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
		CHEMBL3819434	140869	0	None	-77	8	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	426	6	1	4	5.8	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
		CHEMBL3819713	140869	0	None	-77	8	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	426	6	1	4	5.8	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
		118724647	120606	0	None	-5	4	Human	6.0	pKi	=	6	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	381	6	0	7	1.7	Cn1c(=O)c2c(ncn2CCCCCN2CCc3ccccc3C2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		CHEMBL3361004	120606	0	None	-5	4	Human	6.0	pKi	=	6	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	381	6	0	7	1.7	Cn1c(=O)c2c(ncn2CCCCCN2CCc3ccccc3C2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		CHEMBL3546104	120606	0	None	-5	4	Human	6.0	pKi	=	6	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	381	6	0	7	1.7	Cn1c(=O)c2c(ncn2CCCCCN2CCc3ccccc3C2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		11603887	102590	0	None	-3	2	Rat	7.0	pKi	=	7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	407	10	1	4	3.5	O=C1C2CCCN2C(=O)N1CCCCNCCOc1ccccc1-c1ccccc1	10.1021/jm400766k
		CHEMBL2431046	102590	0	None	-3	2	Rat	7.0	pKi	=	7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	407	10	1	4	3.5	O=C1C2CCCN2C(=O)N1CCCCNCCOc1ccccc1-c1ccccc1	10.1021/jm400766k
		CHEMBL3040877	102590	0	None	-3	2	Rat	7.0	pKi	=	7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	407	10	1	4	3.5	O=C1C2CCCN2C(=O)N1CCCCNCCOc1ccccc1-c1ccccc1	10.1021/jm400766k
		90654670	110091	0	None	1	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	427	9	1	6	2.4	NC(=O)[C@@H]1CCCN1C(=O)CCCCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235742	110091	0	None	1	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	427	9	1	6	2.4	NC(=O)[C@@H]1CCCN1C(=O)CCCCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
		136180321	117715	0	None	1	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	1	4	4.1	O=c1[nH]c(CCCCCN2CCN(c3ccc(Cl)cc3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
		CHEMBL3401483	117715	0	None	1	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	1	4	4.1	O=c1[nH]c(CCCCCN2CCN(c3ccc(Cl)cc3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
		11291892	133513	3	None	-24	3	Rat	7.0	pKi	=	7	Binding	In vitro inhibition of [3H]5-CT binding to 5-hydroxytryptamine 7 receptor in rat hypothalamus membranesIn vitro inhibition of [3H]5-CT binding to 5-hydroxytryptamine 7 receptor in rat hypothalamus membranes	ChEMBL	378	3	0	4	1.8	O=C1[C@@H]2CCCN2C(=O)CN1CN1CCN(c2cccc3ccccc23)CC1	10.1021/jm048999e
		CHEMBL370758	133513	3	None	-24	3	Rat	7.0	pKi	=	7	Binding	In vitro inhibition of [3H]5-CT binding to 5-hydroxytryptamine 7 receptor in rat hypothalamus membranesIn vitro inhibition of [3H]5-CT binding to 5-hydroxytryptamine 7 receptor in rat hypothalamus membranes	ChEMBL	378	3	0	4	1.8	O=C1[C@@H]2CCCN2C(=O)CN1CN1CCN(c2cccc3ccccc23)CC1	10.1021/jm048999e
		10994400	205121	0	None	-109	4	Human	7.0	pKi	=	7	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	439	5	1	2	4.4	OC(c1ccc(F)cc1)C1CCN(CCc2ccccc2I)CC1	10.1021/jm0200411
		CHEMBL77855	205121	0	None	-109	4	Human	7.0	pKi	=	7	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	439	5	1	2	4.4	OC(c1ccc(F)cc1)C1CCN(CCc2ccccc2I)CC1	10.1021/jm0200411
		2880253	162707	9	None	-1	3	Human	5.0	pKi	=	5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	351	7	1	2	5.4	CCC1(C)CC(CCNCc2ccccc2)(c2ccc(C)cc2)CCO1	10.1016/j.ejmech.2018.04.010
		CHEMBL4170813	162707	9	None	-1	3	Human	5.0	pKi	=	5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	351	7	1	2	5.4	CCC1(C)CC(CCNCc2ccccc2)(c2ccc(C)cc2)CCO1	10.1016/j.ejmech.2018.04.010
		71457409	82962	0	None	-3981	5	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	461	5	0	4	4.9	CCCN1CCC(COc2nc3c(I)cccc3c3ncccc23)CC1	10.1021/jm300943r
		CHEMBL2181168	82962	0	None	-3981	5	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	461	5	0	4	4.9	CCCN1CCC(COc2nc3c(I)cccc3c3ncccc23)CC1	10.1021/jm300943r
		134147951	149804	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	271	5	0	3	3.4	COc1ccccc1-c1cc(CN(C)C)ccc1OC	10.1016/j.ejmech.2016.07.029
		CHEMBL3948597	149804	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	271	5	0	3	3.4	COc1ccccc1-c1cc(CN(C)C)ccc1OC	10.1016/j.ejmech.2016.07.029
		10737314	97271	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	361	4	1	3	3.4	O=C1Nc2cccc3c2C1(CCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm980519u
		CHEMBL268921	97271	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	361	4	1	3	3.4	O=C1Nc2cccc3c2C1(CCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm980519u
		CHEMBL5076882	214466	0	None	-26	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		C[C@H]1C[C@H](NS(=O)(=O)c2cccc(Cl)c2)CN1CCCc1noc2cc(F)ccc12	10.1021/acs.jmedchem.1c00497
		CHEMBL5083505	214866	0	None	-2	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1cccc(F)c1	10.1021/acs.jmedchem.1c00497
		1534	103040	53	None	1	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
		9287	103040	53	None	1	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
		CHEMBL30713	103040	53	None	1	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
		10314060	168600	0	None	-72	7	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	322	4	1	4	2.9	COc1ccccc1N1CCN(Cc2c[nH]c3ncccc23)CC1	10.1016/s0960-894x(01)00241-4
		CHEMBL435949	168600	0	None	-72	7	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	322	4	1	4	2.9	COc1ccccc1N1CCN(Cc2c[nH]c3ncccc23)CC1	10.1016/s0960-894x(01)00241-4
		122442272	138348	0	None	-40	15	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human 5HT7 receptor by radioligand binding assayBinding affinity to human 5HT7 receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
		CHEMBL3769968	138348	0	None	-40	15	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human 5HT7 receptor by radioligand binding assayBinding affinity to human 5HT7 receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
		CHEMBL3771384	138348	0	None	-40	15	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human 5HT7 receptor by radioligand binding assayBinding affinity to human 5HT7 receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
		18137015	164340	0	None	1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2ccccc2Cl)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
		CHEMBL4212558	164340	0	None	1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2ccccc2Cl)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
		23369457	189515	2	None	-2	2	Human	6.0	pKi	=	6.0	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	322	4	1	4	2.2	O=c1[nH]c2ccccc2n1CCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2009.02.008
		CHEMBL514058	189515	2	None	-2	2	Human	6.0	pKi	=	6.0	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	322	4	1	4	2.2	O=c1[nH]c2ccccc2n1CCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2009.02.008
		10754042	99800	0	None	2	4	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	263	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3O	10.1021/jm9911433
		CHEMBL285352	99800	0	None	2	4	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	263	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3O	10.1021/jm9911433
		1534	103040	53	None	1	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
		9287	103040	53	None	1	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
		CHEMBL30713	103040	53	None	1	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
		134135372	144397	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	295	4	0	2	4.6	COc1ccccc1-c1cccc(CN2CCC(C)CC2)c1	10.1016/j.ejmech.2016.07.029
		CHEMBL3906019	144397	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	295	4	0	2	4.6	COc1ccccc1-c1cccc(CN2CCC(C)CC2)c1	10.1016/j.ejmech.2016.07.029
		168291659	192038	0	None	-14	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	356	8	3	8	1.4	Nc1nc(N)nc(NCCCCCN2CCN(c3ccccc3)CC2)n1	10.1016/j.ejmech.2021.113931
		CHEMBL5202120	192038	0	None	-14	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	356	8	3	8	1.4	Nc1nc(N)nc(NCCCCCN2CCN(c3ccccc3)CC2)n1	10.1016/j.ejmech.2021.113931
		135414318	207785	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	298	0	1	5	3.1	CN1CCN(C2=Nc3ccccc3Nc3sccc32)CC1	10.1021/jm030030n
		CHEMBL96055	207785	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	298	0	1	5	3.1	CN1CCN(C2=Nc3ccccc3Nc3sccc32)CC1	10.1021/jm030030n
		145978146	163916	0	None	4	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	450	9	2	5	3.1	CC(C)c1ccccc1OCC(O)CN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2017.03.057
		CHEMBL4207310	163916	0	None	4	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	450	9	2	5	3.1	CC(C)c1ccccc1OCC(O)CN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2017.03.057
		156013326	177494	0	None	1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	350	4	1	4	3.8	COc1cc2c3c(c1OCC1CC1)-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
		CHEMBL4639400	177494	0	None	1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	350	4	1	4	3.8	COc1cc2c3c(c1OCC1CC1)-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
		124247485	164069	8	None	-1	8	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		CHEMBL4209274	164069	8	None	-1	8	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		124247485	164069	8	None	-1	8	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		CHEMBL4209274	164069	8	None	-1	8	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		2950739	162963	10	None	-4	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	351	9	1	4	4.6	COc1ccc(CNCCC(c2ccco2)c2ccccc2OC)cc1	10.1016/j.ejmech.2018.04.010
		CHEMBL4174845	162963	10	None	-4	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	351	9	1	4	4.6	COc1ccc(CNCCC(c2ccco2)c2ccccc2OC)cc1	10.1016/j.ejmech.2018.04.010
		57403525	70154	0	None	-691	10	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	361	6	1	2	4.8	OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
		CHEMBL1940402	70154	0	None	-691	10	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	361	6	1	2	4.8	OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
		21533446	70155	0	None	-281	10	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	379	6	1	3	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
		CHEMBL1940403	70155	0	None	-281	10	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	379	6	1	3	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
		122483264	138092	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	334	6	0	3	5.1	O=C(CCCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3763534	138092	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	334	6	0	3	5.1	O=C(CCCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765840	138092	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	334	6	0	3	5.1	O=C(CCCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		71726944	102404	0	None	1	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	342	2	0	4	3.3	CN1CCN(Cc2cccc3c(=O)c4ccc(Cl)cc4oc23)CC1	10.1016/j.bmcl.2013.05.062
		CHEMBL3039669	102404	0	None	1	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	342	2	0	4	3.3	CN1CCN(Cc2cccc3c(=O)c4ccc(Cl)cc4oc23)CC1	10.1016/j.bmcl.2013.05.062
		CHEMBL3215698	102404	0	None	1	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	342	2	0	4	3.3	CN1CCN(Cc2cccc3c(=O)c4ccc(Cl)cc4oc23)CC1	10.1016/j.bmcl.2013.05.062
		44388796	128060	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Binding affinity against rat 5-HT7R expressed in HEK293 cellsBinding affinity against rat 5-HT7R expressed in HEK293 cells	ChEMBL	415	5	0	4	4.8	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C(F)(F)F)c2)CC1	10.1016/j.bmcl.2005.05.059
		CHEMBL366516	128060	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Binding affinity against rat 5-HT7R expressed in HEK293 cellsBinding affinity against rat 5-HT7R expressed in HEK293 cells	ChEMBL	415	5	0	4	4.8	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C(F)(F)F)c2)CC1	10.1016/j.bmcl.2005.05.059
		11131952	49354	0	None	-1	2	Rat	7.0	pKi	=	7.0	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	353	8	1	5	3.4	O=C(CCCCCN1CCN(c2ccccn2)CC1)c1ccccc1O	10.1021/jm020994z
		CHEMBL156385	49354	0	None	-1	2	Rat	7.0	pKi	=	7.0	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	353	8	1	5	3.4	O=C(CCCCCN1CCN(c2ccccn2)CC1)c1ccccc1O	10.1021/jm020994z
		156016142	177748	0	None	-5	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	506	8	0	6	5.3	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
		CHEMBL4642594	177748	0	None	-5	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	506	8	0	6	5.3	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
		155554326	174948	0	None	-13	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	457	9	0	6	3.2	COc1ccccc1N1CCN(CCCCCCN2C(=O)c3ccccc3S2(=O)=O)CC1	10.1016/j.bmcl.2021.128028
		CHEMBL4565558	174948	0	None	-13	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	457	9	0	6	3.2	COc1ccccc1N1CCN(CCCCCCN2C(=O)c3ccccc3S2(=O)=O)CC1	10.1016/j.bmcl.2021.128028
		10638372	174386	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	306	4	0	2	3.0	O=C1Cc2ccccc2N1CCCN1CCc2ccccc2C1	10.1021/jm8014553
		CHEMBL455210	174386	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	306	4	0	2	3.0	O=C1Cc2ccccc2N1CCCN1CCc2ccccc2C1	10.1021/jm8014553
		145946265	167514	0	None	-1	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	396	10	0	4	3.9	Cc1cc(C)c(OCCOCCN2CCN(CCc3ccccc3)CC2)c(C)c1	10.1016/j.bmcl.2018.04.059
		CHEMBL4203310	167514	0	None	-1	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	396	10	0	4	3.9	Cc1cc(C)c(OCCOCCN2CCN(CCc3ccccc3)CC2)c(C)c1	10.1016/j.bmcl.2018.04.059
		CHEMBL4299892	167514	0	None	-1	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	396	10	0	4	3.9	Cc1cc(C)c(OCCOCCN2CCN(CCc3ccccc3)CC2)c(C)c1	10.1016/j.bmcl.2018.04.059
		122483264	138092	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	334	6	0	3	5.1	O=C(CCCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3763534	138092	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	334	6	0	3	5.1	O=C(CCCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765840	138092	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	334	6	0	3	5.1	O=C(CCCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		155536533	172186	0	None	-2	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	444	7	1	5	4.8	O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2cc(-c3ccccc3)sc12	10.1016/j.ejmech.2019.111690
		CHEMBL4473636	172186	0	None	-2	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	444	7	1	5	4.8	O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2cc(-c3ccccc3)sc12	10.1016/j.ejmech.2019.111690
		155547693	173571	0	None	-51	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	314	4	1	7	1.1	Cc1cccc(OCc2nc(N)nc(N3CCN(C)CC3)n2)c1	10.1016/j.ejmech.2019.06.022
		CHEMBL4532712	173571	0	None	-51	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	314	4	1	7	1.1	Cc1cccc(OCc2nc(N)nc(N3CCN(C)CC3)n2)c1	10.1016/j.ejmech.2019.06.022
		90654683	110104	0	None	6	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	452	8	1	4	2.9	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235755	110104	0	None	6	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	452	8	1	4	2.9	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.03.005
		44437860	91236	0	None	-48	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	411	6	0	4	3.2	CC1C(=O)N(CCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)C(=O)C1C	10.1016/j.bmc.2007.07.029
		CHEMBL240110	91236	0	None	-48	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	411	6	0	4	3.2	CC1C(=O)N(CCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)C(=O)C1C	10.1016/j.bmc.2007.07.029
		53325849	57009	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	322	3	1	2	4.5	Clc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
		CHEMBL1644269	57009	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	322	3	1	2	4.5	Clc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
		54758201	65993	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	451	6	1	3	5.7	O=C1Nc2c(Cl)cc(Cl)cc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm200547z
		CHEMBL1836782	65993	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	451	6	1	3	5.7	O=C1Nc2c(Cl)cc(Cl)cc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm200547z
		60165413	75360	0	None	-31	7	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	378	7	0	4	5.5	O=C(CCCCN1CCC(c2ccccc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
		CHEMBL2037531	75360	0	None	-31	7	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	378	7	0	4	5.5	O=C(CCCCN1CCC(c2ccccc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
		168288780	191448	0	None	-63	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	8	0	6	3.9	O=c1n(CCCCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
		CHEMBL5193103	191448	0	None	-63	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	8	0	6	3.9	O=c1n(CCCCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
		122483226	138106	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	377	5	0	4	3.8	CC(=O)N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3763504	138106	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	377	5	0	4	3.8	CC(=O)N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3765871	138106	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	377	5	0	4	3.8	CC(=O)N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		122483226	138106	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	377	5	0	4	3.8	CC(=O)N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3763504	138106	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	377	5	0	4	3.8	CC(=O)N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3765871	138106	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	377	5	0	4	3.8	CC(=O)N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		90654703	110089	0	None	26	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	399	7	1	6	1.6	NC(=O)[C@@H]1CCCN1C(=O)CCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235740	110089	0	None	26	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	399	7	1	6	1.6	NC(=O)[C@@H]1CCCN1C(=O)CCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
		134147935	149689	0	None	18	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	487	10	1	6	3.6	N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3cccnc3-c3ccc(F)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		CHEMBL3947670	149689	0	None	18	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	487	10	1	6	3.6	N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3cccnc3-c3ccc(F)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		154956306	179664	0	None	-12	6	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	435	6	0	6	4.5	Cn1ccc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2c1=O	10.1016/j.ejmech.2020.112709
		CHEMBL4743324	179664	0	None	-12	6	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	435	6	0	6	4.5	Cn1ccc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2c1=O	10.1016/j.ejmech.2020.112709
		90656690	110985	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	325	7	2	4	2.8	OCc1cccc(NCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262418	110985	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	325	7	2	4	2.8	OCc1cccc(NCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
		118728522	117717	0	None	-3	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	390	8	0	5	3.4	O=c1c2ccccc2ncn1CCCCCN1CCN(Cc2ccccc2)CC1	10.1016/j.bmcl.2015.02.042
		CHEMBL3401485	117717	0	None	-3	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	390	8	0	5	3.4	O=c1c2ccccc2ncn1CCCCCN1CCN(Cc2ccccc2)CC1	10.1016/j.bmcl.2015.02.042
		164616670	184613	0	None	-53	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	424	7	1	7	3.8	CCCCC(Oc1cc(Cl)cc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
		CHEMBL4849077	184613	0	None	-53	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	424	7	1	7	3.8	CCCCC(Oc1cc(Cl)cc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
		11726532	97026	0	None	-141	4	Rat	7.0	pKi	=	7.0	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	368	8	0	5	3.5	COc1cccc(C(=O)CCCN2CCN(c3ccccc3OC)CC2)c1	10.1021/jm020994z
		CHEMBL26677	97026	0	None	-141	4	Rat	7.0	pKi	=	7.0	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	368	8	0	5	3.5	COc1cccc(C(=O)CCCN2CCN(c3ccccc3OC)CC2)c1	10.1021/jm020994z
		44460669	205603	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	283	4	0	3	2.9	C=Cc1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
		CHEMBL81576	205603	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	283	4	0	3	2.9	C=Cc1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
		44460724	205620	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	339	4	0	4	4.0	CN1CCCN(CCn2ccc3ccc(-c4ccsc4)cc32)CC1	10.1016/s0960-894x(02)00438-9
		CHEMBL81684	205620	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	339	4	0	4	4.0	CN1CCCN(CCn2ccc3ccc(-c4ccsc4)cc32)CC1	10.1016/s0960-894x(02)00438-9
		168289915	191554	0	None	-2	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	553	11	4	8	4.9	Nc1nc(NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
		CHEMBL5194614	191554	0	None	-2	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	553	11	4	8	4.9	Nc1nc(NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
		60195992	81810	2	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	256	2	1	2	2.9	Fc1ccc(-c2cccc(N3CCNCC3)c2)cc1	10.1021/jm3003679
		CHEMBL2164333	81810	2	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	256	2	1	2	2.9	Fc1ccc(-c2cccc(N3CCNCC3)c2)cc1	10.1021/jm3003679
		10938620	204066	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	416	7	1	3	5.2	COc1ccc2c3c1CCCC3(CCCCN1CC=C(c3ccccc3)CC1)C(=O)N2	10.1021/jm0104264
		CHEMBL70048	204066	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	416	7	1	3	5.2	COc1ccc2c3c1CCCC3(CCCCN1CC=C(c3ccccc3)CC1)C(=O)N2	10.1021/jm0104264
		155538236	172371	0	None	-40	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	496	7	1	5	5.2	O=c1c(-c2ccccc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
		CHEMBL4476164	172371	0	None	-40	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	496	7	1	5	5.2	O=c1c(-c2ccccc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
		155515920	176684	0	None	-109	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	432	4	2	6	4.3	COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1cccc2ccccc12	10.1016/j.ejmech.2019.06.001
		CHEMBL4442332	176684	0	None	-109	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	432	4	2	6	4.3	COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1cccc2ccccc12	10.1016/j.ejmech.2019.06.001
		CHEMBL4598348	176684	0	None	-109	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	432	4	2	6	4.3	COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1cccc2ccccc12	10.1016/j.ejmech.2019.06.001
		46203754	124545	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2cccc(C)c2C)cc1OC1CNC1	nan
		CHEMBL3640553	124545	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2cccc(C)c2C)cc1OC1CNC1	nan
		10024070	67189	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	402	8	0	4	3.5	CCN(CCCN1CCc2cc(OC)ccc2C1)S(=O)(=O)c1ccc(C)cc1	10.1021/jm049743b
		CHEMBL187764	67189	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	402	8	0	4	3.5	CCN(CCCN1CCc2cc(OC)ccc2C1)S(=O)(=O)c1ccc(C)cc1	10.1021/jm049743b
		46203754	124545	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2cccc(C)c2C)cc1OC1CNC1	nan
		CHEMBL3640553	124545	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2cccc(C)c2C)cc1OC1CNC1	nan
		71458652	81435	0	None	-1	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	410	8	1	5	3.0	CSc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)C1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159478	81435	0	None	-1	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	410	8	1	5	3.0	CSc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)C1	10.1016/j.ejmech.2012.07.043
		118731353	118112	0	None	5	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	524	10	1	4	4.9	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
		CHEMBL3407516	118112	0	None	5	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	524	10	1	4	4.9	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
		145980458	166717	0	None	1	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	476	6	2	5	2.9	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3cccc4ccccc34)CC2)C1=O	10.1039/C8MD00168E
		CHEMBL4282860	166717	0	None	1	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	476	6	2	5	2.9	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3cccc4ccccc34)CC2)C1=O	10.1039/C8MD00168E
		155526720	171210	0	None	3	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	437	6	1	3	5.9	Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2cccs2)c1	10.1016/j.bmcl.2019.126703
		CHEMBL4459410	171210	0	None	3	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	437	6	1	3	5.9	Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2cccs2)c1	10.1016/j.bmcl.2019.126703
		155552707	174048	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	421	6	1	3	5.5	Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccoc2)c1	10.1016/j.bmcl.2019.126703
		CHEMBL4543789	174048	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	421	6	1	3	5.5	Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccoc2)c1	10.1016/j.bmcl.2019.126703
		2726	919	68	None	-13	72	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2013.02.038
		621	919	68	None	-13	72	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2013.02.038
		83	919	68	None	-13	72	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2013.02.038
		CHEMBL71	919	68	None	-13	72	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2013.02.038
		DB00477	919	68	None	-13	72	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2013.02.038
		54758204	65995	0	None	6	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	395	7	1	3	4.4	CCC1(CCCCN2CCN(c3cccc(F)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
		CHEMBL1836784	65995	0	None	6	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	395	7	1	3	4.4	CCC1(CCCCN2CCN(c3cccc(F)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
		11393666	192986	0	None	-28	19	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
		CHEMBL5201983	192986	0	None	-28	19	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
		CHEMBL5222597	192986	0	None	-28	19	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
		42618267	182823	0	None	6	2	Human	8.0	pKi	=	8.0	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	398	7	1	4	4.0	O=c1[nH]c2ccccc2n1CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2009.02.008
		CHEMBL479105	182823	0	None	6	2	Human	8.0	pKi	=	8.0	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	398	7	1	4	4.0	O=c1[nH]c2ccccc2n1CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2009.02.008
		11683077	66002	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	414	6	1	2	5.7	O=C1Nc2ccccc2C1CCCCN1CC=C(c2cccc(C(F)(F)F)c2)CC1	10.1021/jm200547z
		CHEMBL1836791	66002	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	414	6	1	2	5.7	O=C1Nc2ccccc2C1CCCCN1CC=C(c2cccc(C(F)(F)F)c2)CC1	10.1021/jm200547z
		71061887	93118	0	None	66	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccncc3)CC2)cc1	10.1016/j.bmc.2014.01.016
		CHEMBL2442996	93118	0	None	66	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccncc3)CC2)cc1	10.1016/j.bmc.2014.01.016
		71061887	93118	0	None	66	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccncc3)CC2)cc1	10.1016/j.bmcl.2013.09.025
		CHEMBL2442996	93118	0	None	66	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccncc3)CC2)cc1	10.1016/j.bmcl.2013.09.025
		44266284	97344	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	377	5	0	3	5.1	Cc1ccccc1OC1CCN(CCC2CCCc3ccccc3C2=O)CC1	10.1016/s0960-894x(03)00077-5
		CHEMBL269400	97344	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	377	5	0	3	5.1	Cc1ccccc1OC1CCN(CCC2CCCc3ccccc3C2=O)CC1	10.1016/s0960-894x(03)00077-5
		22273749	208187	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	363	4	0	3	4.7	COc1ccccc1C1CCN(CC2CCc3ccccc3C(=O)C2)CC1	10.1016/s0960-894x(03)00077-5
		CHEMBL9840	208187	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	363	4	0	3	4.7	COc1ccccc1C1CCN(CC2CCc3ccccc3C(=O)C2)CC1	10.1016/s0960-894x(03)00077-5
		135398737	958	93	None	-13	89	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2020.115578
		38	958	93	None	-13	89	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2020.115578
		722	958	93	None	-13	89	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2020.115578
		CHEMBL42	958	93	None	-13	89	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2020.115578
		DB00363	958	93	None	-13	89	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2020.115578
		11191128	85210	0	None	2	4	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins	ChEMBL	421	8	2	4	4.3	O=C(CCCCCN1CCN(c2ccccc2O)CC1)NC1CCCc2ccccc21	10.1021/acs.jmedchem.5b00982
		CHEMBL225512	85210	0	None	2	4	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins	ChEMBL	421	8	2	4	4.3	O=C(CCCCCN1CCN(c2ccccc2O)CC1)NC1CCCc2ccccc21	10.1021/acs.jmedchem.5b00982
		11191128	85210	0	None	2	4	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	421	8	2	4	4.3	O=C(CCCCCN1CCN(c2ccccc2O)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
		CHEMBL225512	85210	0	None	2	4	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	421	8	2	4	4.3	O=C(CCCCCN1CCN(c2ccccc2O)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
		134137732	147769	0	None	11	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	485	11	1	4	5.9	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@H](C)c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		CHEMBL3932551	147769	0	None	11	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	485	11	1	4	5.9	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@H](C)c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		179	400	115	None	-9	49	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assayDisplacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assay	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1016/j.bmcl.2021.128275
		2159	400	115	None	-9	49	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assayDisplacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assay	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1016/j.bmcl.2021.128275
		963	400	115	None	-9	49	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assayDisplacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assay	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1016/j.bmcl.2021.128275
		CHEMBL243712	400	115	None	-9	49	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assayDisplacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assay	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1016/j.bmcl.2021.128275
		DB06288	400	115	None	-9	49	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assayDisplacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assay	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1016/j.bmcl.2021.128275
		90656711	110968	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay	ChEMBL	371	4	2	3	4.4	Oc1ccc2[nH]cc(CCN3CCN(c4cccc5ccccc45)CC3)c2c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262393	110968	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay	ChEMBL	371	4	2	3	4.4	Oc1ccc2[nH]cc(CCN3CCN(c4cccc5ccccc45)CC3)c2c1	10.1016/j.ejmech.2014.04.034
		90656711	110968	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	371	4	2	3	4.4	Oc1ccc2[nH]cc(CCN3CCN(c4cccc5ccccc45)CC3)c2c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262393	110968	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	371	4	2	3	4.4	Oc1ccc2[nH]cc(CCN3CCN(c4cccc5ccccc45)CC3)c2c1	10.1016/j.ejmech.2014.04.034
		118713683	114388	0	None	-9	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	409	9	0	6	4.0	COc1ccccc1N1CCN(CCCCCCn2c(=O)oc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
		CHEMBL3331386	114388	0	None	-9	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	409	9	0	6	4.0	COc1ccccc1N1CCN(CCCCCCn2c(=O)oc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
		44266245	167217	0	None	6	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	398	5	0	3	4.3	O=C1c2ccccc2CCCN1CCN1CCC(Oc2ccc(Cl)cc2)CC1	10.1016/s0960-894x(03)00077-5
		CHEMBL429202	167217	0	None	6	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	398	5	0	3	4.3	O=C1c2ccccc2CCCN1CCN1CCC(Oc2ccc(Cl)cc2)CC1	10.1016/s0960-894x(03)00077-5
		136180320	117714	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	1	4	4.1	O=c1[nH]c(CCCCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
		CHEMBL3401482	117714	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	1	4	4.1	O=c1[nH]c(CCCCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
		164622487	186122	0	None	-1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	339	4	0	4	2.8	O=C1c2ccc(F)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
		CHEMBL4871850	186122	0	None	-1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	339	4	0	4	2.8	O=C1c2ccc(F)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
		2470	3653	50	None	-1258	59	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
		3300	3653	50	None	-1258	59	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
		5265	3653	50	None	-1258	59	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
		99	3653	50	None	-1258	59	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
		CHEMBL267930	3653	50	None	-1258	59	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
		CHEMBL5071978	214272	0	None	-1	6	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCN(CC)Cc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		145976686	163922	0	None	24	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	564	7	1	4	3.9	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2I)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
		CHEMBL4207365	163922	0	None	24	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	564	7	1	4	3.9	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2I)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
		56944861	157074	0	None	-42	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	493	8	2	3	5.8	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
		CHEMBL4074195	157074	0	None	-42	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	493	8	2	3	5.8	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
		2470	3653	50	None	-1258	59	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
		3300	3653	50	None	-1258	59	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
		5265	3653	50	None	-1258	59	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
		99	3653	50	None	-1258	59	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
		CHEMBL267930	3653	50	None	-1258	59	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
		2470	3653	50	None	-1258	59	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 minsDisplacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 mins	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.bmc.2016.06.011
		3300	3653	50	None	-1258	59	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 minsDisplacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 mins	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.bmc.2016.06.011
		5265	3653	50	None	-1258	59	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 minsDisplacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 mins	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.bmc.2016.06.011
		99	3653	50	None	-1258	59	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 minsDisplacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 mins	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.bmc.2016.06.011
		CHEMBL267930	3653	50	None	-1258	59	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 minsDisplacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 mins	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.bmc.2016.06.011
		11207101	75944	1	None	-	1	Rat	6.0	pKi	=	6.0	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	236	4	0	4	1.5	COc1ccc2c(c1)N(CCN(C)C)CCO2	10.1021/jm049743b
		CHEMBL2051975	75944	1	None	-	1	Rat	6.0	pKi	=	6.0	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	236	4	0	4	1.5	COc1ccc2c(c1)N(CCN(C)C)CCO2	10.1021/jm049743b
		9818448	127480	1	None	-17	3	Rat	6.0	pKi	=	6.0	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	318	4	1	2	4.5	COc1ccc2[nH]cc(C3=CCN(Cc4ccccc4)CC3)c2c1	10.1021/jm049743b
		CHEMBL366081	127480	1	None	-17	3	Rat	6.0	pKi	=	6.0	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	318	4	1	2	4.5	COc1ccc2[nH]cc(C3=CCN(Cc4ccccc4)CC3)c2c1	10.1021/jm049743b
		1353	1911	93	None	-263	83	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2016.06.011
		3559	1911	93	None	-263	83	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2016.06.011
		86	1911	93	None	-263	83	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2016.06.011
		CHEMBL54	1911	93	None	-263	83	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2016.06.011
		DB00502	1911	93	None	-263	83	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2016.06.011
		198914	146703	8	None	79	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	264	1	3	2	3.1	Oc1cccc(C2NCCc3c2[nH]c2ccccc32)c1	10.1016/j.bmcl.2007.01.093
		CHEMBL392401	146703	8	None	79	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	264	1	3	2	3.1	Oc1cccc(C2NCCc3c2[nH]c2ccccc32)c1	10.1016/j.bmcl.2007.01.093
		71460455	81366	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	430	9	1	4	4.6	CCOc1ccccc1C(=O)NC1CCN(CCOc2cccc(-c3ccccc3)c2)C1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159314	81366	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	430	9	1	4	4.6	CCOc1ccccc1C(=O)NC1CCN(CCOc2cccc(-c3ccccc3)c2)C1	10.1016/j.ejmech.2012.07.043
		71462156	81371	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	445	6	1	4	5.1	O=C(NC1CCN(CCSc2cccc(Cl)c2Cl)C1)c1ccc2ccccc2n1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159319	81371	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	445	6	1	4	5.1	O=C(NC1CCN(CCSc2cccc(Cl)c2Cl)C1)c1ccc2ccccc2n1	10.1016/j.ejmech.2012.07.043
		90654673	110094	0	None	-54	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	494	10	1	5	3.9	CSc1ccccc1N1CCN(CCCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235745	110094	0	None	-54	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	494	10	1	5	3.9	CSc1ccccc1N1CCN(CCCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
		11154555	800	62	None	-117	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2019.111736
		5037	800	62	None	-117	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2019.111736
		7671	800	62	None	-117	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2019.111736
		CHEMBL2028019	800	62	None	-117	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2019.111736
		CHEMBL3085826	800	62	None	-117	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2019.111736
		DB06016	800	62	None	-117	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2019.111736
		118736376	118948	0	None	-5	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	531	7	0	9	3.3	Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.ejmech.2015.04.046
		CHEMBL3423340	118948	0	None	-5	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	531	7	0	9	3.3	Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.ejmech.2015.04.046
		127052487	140800	0	None	-6	6	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	422	6	2	3	5.1	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2016.06.011
		CHEMBL3818805	140800	0	None	-6	6	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	422	6	2	3	5.1	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2016.06.011
		90656681	110980	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	327	6	0	3	3.5	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(F)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262413	110980	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	327	6	0	3	3.5	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(F)c1	10.1016/j.ejmech.2014.04.034
		155561995	175722	0	None	-36	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	532	7	1	5	5.4	O=c1c(-c2ccc(F)cc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccc(F)cc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
		CHEMBL4582567	175722	0	None	-36	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	532	7	1	5	5.4	O=c1c(-c2ccc(F)cc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccc(F)cc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
		155522218	170637	0	None	-51	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	492	7	1	5	5.3	O=c1c(-c2ccccc2)c2ccccn2c(=O)n1CCCCN1CCCC(c2c[nH]c3ccccc23)C1	10.1016/j.ejmech.2019.01.031
		CHEMBL4451231	170637	0	None	-51	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	492	7	1	5	5.3	O=c1c(-c2ccccc2)c2ccccn2c(=O)n1CCCCN1CCCC(c2c[nH]c3ccccc23)C1	10.1016/j.ejmech.2019.01.031
		145983018	165517	0	None	-125	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	1	7	3.0	O=c1[nH]c2c(N3CCN(CC[C@@H]4CCCN4S(=O)(=O)c4cccc5ncccc45)CC3)cccc2o1	10.1016/j.ejmech.2018.01.002
		CHEMBL4240910	165517	0	None	-125	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	1	7	3.0	O=c1[nH]c2c(N3CCN(CC[C@@H]4CCCN4S(=O)(=O)c4cccc5ncccc45)CC3)cccc2o1	10.1016/j.ejmech.2018.01.002
		46204083	124551	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	357	4	1	3	4.4	COc1ccc(-c2c(Cl)cccc2C(F)(F)F)cc1OC1CNC1	nan
		CHEMBL3640559	124551	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	357	4	1	3	4.4	COc1ccc(-c2c(Cl)cccc2C(F)(F)F)cc1OC1CNC1	nan
		46204083	124551	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	357	4	1	3	4.4	COc1ccc(-c2c(Cl)cccc2C(F)(F)F)cc1OC1CNC1	nan
		CHEMBL3640559	124551	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	357	4	1	3	4.4	COc1ccc(-c2c(Cl)cccc2C(F)(F)F)cc1OC1CNC1	nan
		118724648	116465	0	None	-5	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	515	7	0	10	1.5	Cn1c(=O)c2c(nc(N3CCOCC3)n2CCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		CHEMBL3361005	116465	0	None	-5	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	515	7	0	10	1.5	Cn1c(=O)c2c(nc(N3CCOCC3)n2CCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		127052487	140800	0	None	-6	6	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	422	6	2	3	5.1	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2016.06.011
		CHEMBL3818805	140800	0	None	-6	6	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	422	6	2	3	5.1	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2016.06.011
		49756	204312	13	None	-14	8	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	232	4	1	2	2.6	COc1ccc2[nH]c(C)c(CCN(C)C)c2c1	10.1021/jm030826m
		CHEMBL7143	204312	13	None	-14	8	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	232	4	1	2	2.6	COc1ccc2[nH]c(C)c(CCN(C)C)c2c1	10.1021/jm030826m
		1353	1911	93	None	-263	83	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2016.06.011
		3559	1911	93	None	-263	83	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2016.06.011
		86	1911	93	None	-263	83	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2016.06.011
		CHEMBL54	1911	93	None	-263	83	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2016.06.011
		DB00502	1911	93	None	-263	83	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2016.06.011
		134154108	152620	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	309	4	0	2	4.9	COc1ccccc1-c1cc(CN2CCC(C)CC2)ccc1C	10.1016/j.ejmech.2016.07.029
		CHEMBL3972166	152620	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	309	4	0	2	4.9	COc1ccccc1-c1cc(CN2CCC(C)CC2)ccc1C	10.1016/j.ejmech.2016.07.029
		90654701	110087	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	426	7	1	4	2.8	NC(=O)[C@@H]1CCCN1C(=O)CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235738	110087	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	426	7	1	4	2.8	NC(=O)[C@@H]1CCCN1C(=O)CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.ejmech.2014.03.005
		57398619	71566	0	None	7	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	444	7	1	5	3.4	O=S(=O)(NCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cncc2ccccc12	10.1016/j.bmc.2011.12.039
		CHEMBL1949962	71566	0	None	7	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	444	7	1	5	3.4	O=S(=O)(NCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cncc2ccccc12	10.1016/j.bmc.2011.12.039
		CHEMBL1963099	71566	0	None	7	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	444	7	1	5	3.4	O=S(=O)(NCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cncc2ccccc12	10.1016/j.bmc.2011.12.039
		136180318	117712	0	None	-14	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	396	6	1	4	3.7	O=c1[nH]c(CCCCN2CCN(c3ccc(Cl)cc3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
		CHEMBL3401480	117712	0	None	-14	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	396	6	1	4	3.7	O=c1[nH]c(CCCCN2CCN(c3ccc(Cl)cc3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
		46204089	124558	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2cc(C)ccc2C)cc1OC1CNC1	nan
		CHEMBL3640565	124558	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2cc(C)ccc2C)cc1OC1CNC1	nan
		46204089	124558	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2cc(C)ccc2C)cc1OC1CNC1	nan
		CHEMBL3640565	124558	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2cc(C)ccc2C)cc1OC1CNC1	nan
		44286416	141418	0	None	-11	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	448	8	0	6	4.3	O=C1c2ccccc2C(=O)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
		CHEMBL38409	141418	0	None	-11	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	448	8	0	6	4.3	O=C1c2ccccc2C(=O)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
		156014787	177545	0	None	3	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	428	6	1	5	3.6	COc1cc2c3c(c1OCC1CC1)-c1cc(NS(C)(=O)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
		CHEMBL4640281	177545	0	None	3	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	428	6	1	5	3.6	COc1cc2c3c(c1OCC1CC1)-c1cc(NS(C)(=O)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
		15443	117810	96	None	-17	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2021.113243
		CHEMBL340211	117810	96	None	-17	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2021.113243
		15443	117810	96	None	-17	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
		CHEMBL340211	117810	96	None	-17	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
		162673483	183772	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	396	8	2	5	2.3	COc1ccccc1N1CCN(CCCC(=O)Nc2ccccc2C(N)=O)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4796251	183772	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	396	8	2	5	2.3	COc1ccccc1N1CCN(CCCC(=O)Nc2ccccc2C(N)=O)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4803945	183772	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	396	8	2	5	2.3	COc1ccccc1N1CCN(CCCC(=O)Nc2ccccc2C(N)=O)CC1	10.1016/j.ejmech.2020.112437
		71458622	81358	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	376	7	1	5	3.7	CSc1ccccc1OCCN1CCC(NC(=O)c2cccs2)CC1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159306	81358	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	376	7	1	5	3.7	CSc1ccccc1OCCN1CCC(NC(=O)c2cccs2)CC1	10.1016/j.ejmech.2012.07.043
		71727068	91267	0	None	-2	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	430	5	0	6	4.3	COc1ccc2c(=O)c3cc(CN4CCN(c5ccccc5OC)CC4)ccc3oc2c1	10.1016/j.bmcl.2013.05.062
		CHEMBL2401934	91267	0	None	-2	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	430	5	0	6	4.3	COc1ccc2c(=O)c3cc(CN4CCN(c5ccccc5OC)CC4)ccc3oc2c1	10.1016/j.bmcl.2013.05.062
		CHEMBL2401938	91267	0	None	-2	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	430	5	0	6	4.3	COc1ccc2c(=O)c3cc(CN4CCN(c5ccccc5OC)CC4)ccc3oc2c1	10.1016/j.bmcl.2013.05.062
		155510928	176469	0	None	-575	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	368	4	2	6	2.9	COc1ccc2c(c1)c(-c1cnc(N)[nH]1)cn2S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2019.06.001
		CHEMBL4435010	176469	0	None	-575	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	368	4	2	6	2.9	COc1ccc2c(c1)c(-c1cnc(N)[nH]1)cn2S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2019.06.001
		CHEMBL4596543	176469	0	None	-575	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	368	4	2	6	2.9	COc1ccc2c(c1)c(-c1cnc(N)[nH]1)cn2S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2019.06.001
		13069623	120609	0	None	-50	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	396	6	0	8	1.0	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		CHEMBL3360994	120609	0	None	-50	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	396	6	0	8	1.0	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		CHEMBL3546108	120609	0	None	-50	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	396	6	0	8	1.0	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		44456400	12834	0	None	-4	10	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		CHEMBL1188501	12834	0	None	-4	10	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		CHEMBL2436555	12834	0	None	-4	10	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		CHEMBL536539	12834	0	None	-4	10	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		10317139	67076	0	None	-758	2	Rat	4.9	pKi	=	4.9	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	371	4	0	5	2.3	COc1ccccc1N1CCN([C@H]2CC[C@H](N3C(=O)CCC3=O)CC2)CC1	10.1016/j.bmcl.2004.09.029
		CHEMBL187270	67076	0	None	-758	2	Rat	4.9	pKi	=	4.9	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	371	4	0	5	2.3	COc1ccccc1N1CCN([C@H]2CC[C@H](N3C(=O)CCC3=O)CC2)CC1	10.1016/j.bmcl.2004.09.029
		145973438	164523	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccc(Cl)cc1	10.1021/acs.jmedchem.8b00828
		CHEMBL4214853	164523	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccc(Cl)cc1	10.1021/acs.jmedchem.8b00828
		145971588	164553	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1cccc(Br)c1	10.1021/acs.jmedchem.8b00828
		CHEMBL4215182	164553	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1cccc(Br)c1	10.1021/acs.jmedchem.8b00828
		155539483	172862	0	None	-162	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	504	7	2	3	5.4	O=C1CC(c2c[nH]c3ccc(F)cc23)C(=O)N1CCCCN1CCC(c2c[nH]c3ccc(F)cc23)CC1	10.1016/j.ejmech.2019.111736
		CHEMBL4515160	172862	0	None	-162	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	504	7	2	3	5.4	O=C1CC(c2c[nH]c3ccc(F)cc23)C(=O)N1CCCCN1CCC(c2c[nH]c3ccc(F)cc23)CC1	10.1016/j.ejmech.2019.111736
		44456400	12834	0	None	-4	10	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		CHEMBL1188501	12834	0	None	-4	10	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		CHEMBL2436555	12834	0	None	-4	10	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		CHEMBL536539	12834	0	None	-4	10	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		122181336	121878	0	None	-8	3	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	432	6	1	4	3.4	O=C1NC2(CCCc3ccccc32)C(=O)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2015.04.026
		CHEMBL3590088	121878	0	None	-8	3	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	432	6	1	4	3.4	O=C1NC2(CCCc3ccccc32)C(=O)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2015.04.026
		118731347	118184	0	None	-7	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	10	1	4	3.4	CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.12.041
		CHEMBL3409031	118184	0	None	-7	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	10	1	4	3.4	CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.12.041
		44455426	155149	0	None	-1	12	Human	6.9	pKi	=	6.9	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL402143	155149	0	None	-1	12	Human	6.9	pKi	=	6.9	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		72198191	89820	0	None	-144	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	458	5	2	3	4.5	O=C1CC(c2c[nH]c3ccccc23)C(=O)N1CCN1CCC(c2c[nH]c3ccc(F)cc23)CC1	10.1016/j.ejmech.2013.02.033
		CHEMBL2377445	89820	0	None	-144	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	458	5	2	3	4.5	O=C1CC(c2c[nH]c3ccccc23)C(=O)N1CCN1CCC(c2c[nH]c3ccc(F)cc23)CC1	10.1016/j.ejmech.2013.02.033
		46205373	124587	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	321	3	1	2	4.5	COc1ccc(-c2cccc(C(F)(F)F)c2)cc1C1CCNC1	nan
		CHEMBL3640593	124587	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	321	3	1	2	4.5	COc1ccc(-c2cccc(C(F)(F)F)c2)cc1C1CCNC1	nan
		46205373	124587	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	321	3	1	2	4.5	COc1ccc(-c2cccc(C(F)(F)F)c2)cc1C1CCNC1	nan
		CHEMBL3640593	124587	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	321	3	1	2	4.5	COc1ccc(-c2cccc(C(F)(F)F)c2)cc1C1CCNC1	nan
		122181339	121881	0	None	-22	3	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	500	6	1	4	4.4	O=C1NC2(CCCc3ccccc32)C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2015.04.026
		CHEMBL3590091	121881	0	None	-22	3	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	500	6	1	4	4.4	O=C1NC2(CCCc3ccccc32)C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2015.04.026
		156013203	177482	0	None	-3	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	477	8	0	4	4.7	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmc.2020.115459
		CHEMBL4639203	177482	0	None	-3	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	477	8	0	4	4.7	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmc.2020.115459
		156021656	178187	0	None	-3	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	269	2	0	1	3.9	CN(C)C1CCc2c(cccc2-c2ccc(F)cc2)C1	10.1016/j.bmc.2019.115262
		CHEMBL4649308	178187	0	None	-3	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	269	2	0	1	3.9	CN(C)C1CCc2c(cccc2-c2ccc(F)cc2)C1	10.1016/j.bmc.2019.115262
		162647097	179719	0	None	-125	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	465	8	1	6	4.0	COc1ccc2cc(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)ccc2c1	10.1016/j.ejmech.2020.112149
		CHEMBL4744007	179719	0	None	-125	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	465	8	1	6	4.0	COc1ccc2cc(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)ccc2c1	10.1016/j.ejmech.2020.112149
		156020908	178031	0	None	-2	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	498	8	0	6	5.4	O=C1c2cccc3cccc(c23)C(=O)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
		CHEMBL4646868	178031	0	None	-2	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	498	8	0	6	5.4	O=C1c2cccc3cccc(c23)C(=O)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
		54758298	66008	0	None	-4	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	401	6	1	3	4.5	O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2014.08.023
		CHEMBL1836857	66008	0	None	-4	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	401	6	1	3	4.5	O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2014.08.023
		11207101	75944	1	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	236	4	0	4	1.5	COc1ccc2c(c1)N(CCN(C)C)CCO2	10.1021/jm049743b
		CHEMBL2051975	75944	1	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	236	4	0	4	1.5	COc1ccc2c(c1)N(CCN(C)C)CCO2	10.1021/jm049743b
		44263956	204448	1	None	-2	2	Rat	5.9	pKi	=	5.9	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	232	4	0	3	2.3	COc1ccc2c(c1)c(CCN(C)C)cn2C	10.1021/jm049743b
		CHEMBL7220	204448	1	None	-2	2	Rat	5.9	pKi	=	5.9	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	232	4	0	3	2.3	COc1ccc2c(c1)c(CCN(C)C)cn2C	10.1021/jm049743b
		90654700	110086	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	390	8	1	4	2.0	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235737	110086	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	390	8	1	4	2.0	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.03.005
		71454899	81160	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	10	1	5	4.3	CCOc1ccccc1C(=O)NCC1CCN(CCOc2ccccc2SC)CC1	10.1016/j.ejmech.2012.07.043
		CHEMBL2158026	81160	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	10	1	5	4.3	CCOc1ccccc1C(=O)NCC1CCN(CCOc2ccccc2SC)CC1	10.1016/j.ejmech.2012.07.043
		155526651	171174	0	None	-5	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	464	8	0	4	5.7	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc3cccnc23)CC1	10.1016/j.bmcl.2019.06.029
		CHEMBL4458938	171174	0	None	-5	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	464	8	0	4	5.7	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc3cccnc23)CC1	10.1016/j.bmcl.2019.06.029
		155540823	172540	0	None	-7	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	456	7	0	5	3.6	CCOc1ccccc1N1CCN(CCC(=O)N2CCN(c3cccc(Cl)c3)CC2)CC1	10.1016/j.bmcl.2016.06.080
		CHEMBL4483779	172540	0	None	-7	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	456	7	0	5	3.6	CCOc1ccccc1N1CCN(CCC(=O)N2CCN(c3cccc(Cl)c3)CC2)CC1	10.1016/j.bmcl.2016.06.080
		2726	919	68	None	-13	72	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2013.12.024
		621	919	68	None	-13	72	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2013.12.024
		83	919	68	None	-13	72	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2013.12.024
		CHEMBL71	919	68	None	-13	72	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2013.12.024
		DB00477	919	68	None	-13	72	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2013.12.024
		11409589	85130	0	None	-1	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	435	9	1	4	4.6	COc1cccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)c1	10.1021/jm049702f
		CHEMBL224883	85130	0	None	-1	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	435	9	1	4	4.6	COc1cccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)c1	10.1021/jm049702f
		127029649	138172	0	None	5	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	462	6	2	5	2.1	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(F)cc3F)CC2)C1=O	10.1016/j.ejmech.2016.02.024
		CHEMBL3769536	138172	0	None	5	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	462	6	2	5	2.1	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(F)cc3F)CC2)C1=O	10.1016/j.ejmech.2016.02.024
		126720403	162610	0	None	-933	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	353	4	1	5	3.2	CC(C)c1nc2c(N3CCNCC3)ccnc2n1Cc1cccc(F)c1	10.1016/j.ejmech.2017.12.053
		CHEMBL4169236	162610	0	None	-933	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	353	4	1	5	3.2	CC(C)c1nc2c(N3CCNCC3)ccnc2n1Cc1cccc(F)c1	10.1016/j.ejmech.2017.12.053
		155542321	173125	0	None	-1096	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	356	5	1	7	2.2	Cc1ccc(C(C)C)c(OCc2nc(N)nc(N3CCN(C)CC3)n2)c1	10.1016/j.ejmech.2019.06.022
		CHEMBL4520796	173125	0	None	-1096	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	356	5	1	7	2.2	Cc1ccc(C(C)C)c(OCc2nc(N)nc(N3CCN(C)CC3)n2)c1	10.1016/j.ejmech.2019.06.022
		155542321	173125	0	None	-1096	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	356	5	1	7	2.2	Cc1ccc(C(C)C)c(OCc2nc(N)nc(N3CCN(C)CC3)n2)c1	10.1016/j.ejmech.2022.114645
		CHEMBL4520796	173125	0	None	-1096	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	356	5	1	7	2.2	Cc1ccc(C(C)C)c(OCc2nc(N)nc(N3CCN(C)CC3)n2)c1	10.1016/j.ejmech.2022.114645
		90654685	110106	0	None	-5	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	522	5	1	4	4.4	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)c1ccc(CN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235757	110106	0	None	-5	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	522	5	1	4	4.4	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)c1ccc(CN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1016/j.ejmech.2014.03.005
		162670959	183754	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	7	1	4	4.5	COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4791316	183754	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	7	1	4	4.5	COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4803791	183754	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	7	1	4	4.5	COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
		90654694	110080	0	None	-27	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	402	9	1	5	1.9	COc1ccccc1N1CCN(CCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235731	110080	0	None	-27	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	402	9	1	5	1.9	COc1ccccc1N1CCN(CCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
		10947658	28702	0	None	-10	16	Human	7.9	pKi	=	7.9	Binding	Binding affinities against 5-hydroxytryptamine 7 receptorBinding affinities against 5-hydroxytryptamine 7 receptor	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		CHEMBL137781	28702	0	None	-10	16	Human	7.9	pKi	=	7.9	Binding	Binding affinities against 5-hydroxytryptamine 7 receptorBinding affinities against 5-hydroxytryptamine 7 receptor	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		46214153	110695	0	None	3	5	Rat	7.9	pKi	=	7.9	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	367	5	1	3	4.0	Clc1cccc(COc2ccc(Br)cc2OC2CNC2)c1	10.1021/ml500082j
		CHEMBL3260334	110695	0	None	3	5	Rat	7.9	pKi	=	7.9	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	367	5	1	3	4.0	Clc1cccc(COc2ccc(Br)cc2OC2CNC2)c1	10.1021/ml500082j
		44374299	119537	2	None	17	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	264	5	0	4	3.5	CN(C)CCSc1nc(-c2ccccc2)cs1	10.1016/j.bmcl.2003.11.050
		CHEMBL345803	119537	2	None	17	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	264	5	0	4	3.5	CN(C)CCSc1nc(-c2ccccc2)cs1	10.1016/j.bmcl.2003.11.050
		11603514	71490	0	None	1	4	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	390	11	1	5	4.0	O=C1CSC(=O)N1CCCCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
		CHEMBL1926760	71490	0	None	1	4	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	390	11	1	5	4.0	O=C1CSC(=O)N1CCCCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
		CHEMBL1962492	71490	0	None	1	4	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	390	11	1	5	4.0	O=C1CSC(=O)N1CCCCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
		127026450	137757	0	None	10	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	480	8	1	4	4.8	O=S(=O)(NC1CC2CCC(C1)N2CCOc1cccc(-c2ccccc2)c1)c1cccc(F)c1	10.1016/j.ejmech.2015.11.040
		CHEMBL3759281	137757	0	None	10	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	480	8	1	4	4.8	O=S(=O)(NC1CC2CCC(C1)N2CCOc1cccc(-c2ccccc2)c1)c1cccc(F)c1	10.1016/j.ejmech.2015.11.040
		145985233	165523	0	None	-7	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	6	4.9	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4241050	165523	0	None	-7	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	6	4.9	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1016/j.ejmech.2018.01.002
		145984737	165579	0	None	-23	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cccc2cnccc12)N1CCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4242392	165579	0	None	-23	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cccc2cnccc12)N1CCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
		145985527	165709	0	None	1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	1	4	5.7	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4245622	165709	0	None	1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	1	4	5.7	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1	10.1016/j.ejmech.2018.01.002
		145985823	165924	0	None	-6	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	6	4.9	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4250475	165924	0	None	-6	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	6	4.9	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1016/j.ejmech.2018.01.002
		134153716	152484	0	None	9	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	510	11	1	5	5.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@H](C)c3ccc(C#N)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		CHEMBL3971125	152484	0	None	9	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	510	11	1	5	5.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@H](C)c3ccc(C#N)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		71453252	81361	0	None	15	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	476	8	1	5	4.9	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159309	81361	0	None	15	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	476	8	1	5	4.9	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
		71453282	81448	0	None	-1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	8	1	5	4.5	O=S(=O)(N[C@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159491	81448	0	None	-1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	8	1	5	4.5	O=S(=O)(N[C@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
		71574210	86283	0	None	1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	478	7	1	5	4.0	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1	10.1016/j.ejmech.2012.11.042
		CHEMBL2312934	86283	0	None	1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	478	7	1	5	4.0	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1	10.1016/j.ejmech.2012.11.042
		118731351	118188	0	None	3	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	496	8	1	4	4.1	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
		CHEMBL3409035	118188	0	None	3	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	496	8	1	4	4.1	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
		118731365	118201	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	592	10	0	4	6.4	O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
		CHEMBL3409048	118201	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	592	10	0	4	6.4	O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
		145947977	167715	0	None	48	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	433	6	2	6	1.5	CC1(c2ccccc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2018.01.093
		CHEMBL4162279	167715	0	None	48	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	433	6	2	6	1.5	CC1(c2ccccc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2018.01.093
		CHEMBL4302540	167715	0	None	48	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	433	6	2	6	1.5	CC1(c2ccccc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2018.01.093
		23642275	482	31	None	60	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1016/j.bmc.2019.115262
		8433	482	31	None	60	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1016/j.bmc.2019.115262
		CHEMBL2164327	482	31	None	60	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1016/j.bmc.2019.115262
		71453252	81361	0	None	15	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	476	8	1	5	4.9	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(Cl)s1	10.1039/C5MD00166H
		CHEMBL2159309	81361	0	None	15	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	476	8	1	5	4.9	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(Cl)s1	10.1039/C5MD00166H
		142601335	186421	0	None	44	7	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
		CHEMBL4876193	186421	0	None	44	7	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
		66803497	158511	0	None	-2	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	463	7	2	3	4.9	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(Cl)c1	10.1021/acs.jmedchem.7b00839
		CHEMBL4091193	158511	0	None	-2	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	463	7	2	3	4.9	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(Cl)c1	10.1021/acs.jmedchem.7b00839
		145964944	164081	0	None	-14	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method	ChEMBL	391	4	0	4	5.0	Clc1ccc(CCN2CCN(c3nsc4ccccc34)CC2)cc1Cl	10.1016/j.bmcl.2017.11.007
		CHEMBL4209430	164081	0	None	-14	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method	ChEMBL	391	4	0	4	5.0	Clc1ccc(CCN2CCN(c3nsc4ccccc34)CC2)cc1Cl	10.1016/j.bmcl.2017.11.007
		10862787	103037	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	423	6	1	3	4.9	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2Cl)CC1)CCC3	10.1016/j.bmc.2019.06.028
		CHEMBL307101	103037	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	423	6	1	3	4.9	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2Cl)CC1)CCC3	10.1016/j.bmc.2019.06.028
		90656696	110998	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	367	9	1	4	4.2	CN(CCCCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262430	110998	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	367	9	1	4	4.2	CN(CCCCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		44374299	119537	2	None	17	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	264	5	0	4	3.5	CN(C)CCSc1nc(-c2ccccc2)cs1	10.1016/j.bmc.2010.01.035
		CHEMBL345803	119537	2	None	17	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	264	5	0	4	3.5	CN(C)CCSc1nc(-c2ccccc2)cs1	10.1016/j.bmc.2010.01.035
		127051844	140847	0	None	1	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	322	6	1	3	2.8	NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3819427	140847	0	None	1	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	322	6	1	3	2.8	NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		145988193	167079	0	None	5	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	449	6	1	2	6.0	Fc1cccc(-c2cc(F)ccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.ejmech.2017.12.063
		CHEMBL4289605	167079	0	None	5	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	449	6	1	2	6.0	Fc1cccc(-c2cc(F)ccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.ejmech.2017.12.063
		90656672	110992	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	451	8	1	5	3.8	O=S(=O)(c1ccccc1)N(CCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262425	110992	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	451	8	1	5	3.8	O=S(=O)(c1ccccc1)N(CCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		155565215	175610	0	None	10	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	433	6	1	7	3.5	Nn1c(CCCCN2CCN(c3ccccc3)CC2)nc2c(sc3ccccc32)c1=O	10.1016/j.ejmech.2019.111690
		CHEMBL4580230	175610	0	None	10	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	433	6	1	7	3.5	Nn1c(CCCCN2CCN(c3ccccc3)CC2)nc2c(sc3ccccc32)c1=O	10.1016/j.ejmech.2019.111690
		10862787	103037	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	423	6	1	3	4.9	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2Cl)CC1)CCC3	10.1021/jm0104264
		CHEMBL307101	103037	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	423	6	1	3	4.9	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2Cl)CC1)CCC3	10.1021/jm0104264
		11826723	204243	1	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	464	6	1	2	5.9	O=C1Nc2ccc(Br)c3c2C1(CCCCN1CC=C(c2ccccc2)CC1)CCC3	10.1021/jm0104264
		CHEMBL71057	204243	1	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	464	6	1	2	5.9	O=C1Nc2ccc(Br)c3c2C1(CCCCN1CC=C(c2ccccc2)CC1)CCC3	10.1021/jm0104264
		142601335	186421	0	None	44	7	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
		CHEMBL4876193	186421	0	None	44	7	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
		127051844	140847	0	None	1	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	322	6	1	3	2.8	NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3819427	140847	0	None	1	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	322	6	1	3	2.8	NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		72734860	103957	0	None	-6	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
		CHEMBL3092753	103957	0	None	-6	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
		44456395	95671	0	None	1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	225	1	2	4	2.0	COc1c(Cl)ccc2c1C(C)NC(N)=N2	10.1016/j.bmcl.2007.10.080
		CHEMBL258073	95671	0	None	1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	225	1	2	4	2.0	COc1c(Cl)ccc2c1C(C)NC(N)=N2	10.1016/j.bmcl.2007.10.080
		11302161	67278	0	None	-8	2	Rat	7.9	pKi	=	7.9	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	337	7	0	2	5.3	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccc(OC)cc2)C1	10.1021/jm0498102
		CHEMBL188176	67278	0	None	-8	2	Rat	7.9	pKi	=	7.9	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	337	7	0	2	5.3	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccc(OC)cc2)C1	10.1021/jm0498102
		44319240	106910	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	374	6	1	2	4.8	O=C1Nc2cccc3c2C1(CCCCCN1CCc2ccccc2C1)CCC3	10.1016/s0960-894x(02)00485-7
		CHEMBL314672	106910	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	374	6	1	2	4.8	O=C1Nc2cccc3c2C1(CCCCCN1CCc2ccccc2C1)CCC3	10.1016/s0960-894x(02)00485-7
		135398737	958	93	None	-7	89	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(00)00166-9
		38	958	93	None	-7	89	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(00)00166-9
		722	958	93	None	-7	89	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(00)00166-9
		CHEMBL42	958	93	None	-7	89	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(00)00166-9
		DB00363	958	93	None	-7	89	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(00)00166-9
		6540428	184864	1	None	-7	3	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	353	4	2	4	1.9	CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1016/s0960-894x(00)00166-9
		CHEMBL3989558	184864	1	None	-7	3	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	353	4	2	4	1.9	CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1016/s0960-894x(00)00166-9
		CHEMBL485253	184864	1	None	-7	3	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	353	4	2	4	1.9	CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1016/s0960-894x(00)00166-9
		10571274	99459	0	None	42	3	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligandBinding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligand	ChEMBL	371	3	0	3	5.1	COc1cccc(OC)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm030841r
		CHEMBL283065	99459	0	None	42	3	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligandBinding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligand	ChEMBL	371	3	0	3	5.1	COc1cccc(OC)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm030841r
		135398737	958	93	None	-13	89	Human	7.9	pKi	=	7.9	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030841r
		38	958	93	None	-13	89	Human	7.9	pKi	=	7.9	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030841r
		722	958	93	None	-13	89	Human	7.9	pKi	=	7.9	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030841r
		CHEMBL42	958	93	None	-13	89	Human	7.9	pKi	=	7.9	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030841r
		DB00363	958	93	None	-13	89	Human	7.9	pKi	=	7.9	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030841r
		6540428	184864	1	None	-19	3	Human	7.9	pKi	=	7.9	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	353	4	2	4	1.9	CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/jm030841r
		CHEMBL3989558	184864	1	None	-19	3	Human	7.9	pKi	=	7.9	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	353	4	2	4	1.9	CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/jm030841r
		CHEMBL485253	184864	1	None	-19	3	Human	7.9	pKi	=	7.9	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	353	4	2	4	1.9	CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/jm030841r
		11151958	66971	0	None	-9	3	Rat	7.9	pKi	=	7.9	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	339	7	0	3	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2ccc(OC)cc2)C1	10.1021/jm0498102
		CHEMBL186758	66971	0	None	-9	3	Rat	7.9	pKi	=	7.9	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	339	7	0	3	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2ccc(OC)cc2)C1	10.1021/jm0498102
		71062123	93117	0	None	6	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3cccnc3)CC2)cc1	10.1016/j.bmc.2014.01.016
		CHEMBL2442995	93117	0	None	6	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3cccnc3)CC2)cc1	10.1016/j.bmc.2014.01.016
		71062123	93117	0	None	6	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3cccnc3)CC2)cc1	10.1016/j.bmcl.2013.09.025
		CHEMBL2442995	93117	0	None	6	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3cccnc3)CC2)cc1	10.1016/j.bmcl.2013.09.025
		76284453	105006	0	None	67	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	476	10	1	5	4.0	Cc1ccccc1-c1ccccc1N1CCN(CCOCCC(=O)NCc2ccc(F)nc2)CC1	10.1016/j.bmc.2014.01.016
		CHEMBL3113595	105006	0	None	67	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	476	10	1	5	4.0	Cc1ccccc1-c1ccccc1N1CCN(CCOCCC(=O)NCc2ccc(F)nc2)CC1	10.1016/j.bmc.2014.01.016
		90656713	110969	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	385	4	2	3	4.7	Cc1[nH]c2ccc(O)cc2c1CCN1CCN(c2cccc3ccccc23)CC1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262394	110969	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	385	4	2	3	4.7	Cc1[nH]c2ccc(O)cc2c1CCN1CCN(c2cccc3ccccc23)CC1	10.1016/j.ejmech.2014.04.034
		162662399	181929	0	None	-12	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	399	7	1	5	3.1	Cc1cccc(S(=O)(=O)N[C@H]2CCN(CCCc3noc4ccccc34)C2)c1	10.1016/j.ejmech.2020.112149
		CHEMBL4779739	181929	0	None	-12	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	399	7	1	5	3.1	Cc1cccc(S(=O)(=O)N[C@H]2CCN(CCCc3noc4ccccc34)C2)c1	10.1016/j.ejmech.2020.112149
		11948707	166167	0	None	-158	13	Human	7.9	pKi	=	7.9	Binding	Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	373	7	0	8	0.6	COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1	10.1021/acs.jmedchem.2c00633
		CHEMBL426317	166167	0	None	-158	13	Human	7.9	pKi	=	7.9	Binding	Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	373	7	0	8	0.6	COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1	10.1021/acs.jmedchem.2c00633
		21830793	91835	10	None	-85	45	Human	7.9	pKi	=	7.9	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	10.1016/j.bmc.2013.05.050
		CHEMBL2413154	91835	10	None	-85	45	Human	7.9	pKi	=	7.9	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	10.1016/j.bmc.2013.05.050
		118728524	117719	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	0	5	4.0	O=c1c2ccccc2ncn1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2015.02.042
		CHEMBL3401487	117719	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	0	5	4.0	O=c1c2ccccc2ncn1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2015.02.042
		145990586	166843	0	None	-9	11	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assayBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assay	ChEMBL	297	2	2	4	2.6	COc1cc2c3c(c1OC)-c1ccccc1[C@@H](O)[C@@H]3NCC2	10.1039/C7MD00656J
		CHEMBL4285281	166843	0	None	-9	11	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assayBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assay	ChEMBL	297	2	2	4	2.6	COc1cc2c3c(c1OC)-c1ccccc1[C@@H](O)[C@@H]3NCC2	10.1039/C7MD00656J
		66801425	157186	0	None	-39	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	441	8	2	3	4.5	Cc1cccc(S(=O)(=O)NCCCCN2CC=C(c3c[nH]c4ccc(F)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
		CHEMBL4075673	157186	0	None	-39	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	441	8	2	3	4.5	Cc1cccc(S(=O)(=O)NCCCCN2CC=C(c3c[nH]c4ccc(F)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
		66801354	112083	0	None	-1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	450	7	1	6	3.5	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
		CHEMBL3289977	112083	0	None	-1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	450	7	1	6	3.5	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
		44437329	151600	0	None	-8	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	692	18	0	8	7.1	COc1ccccc1N1CCN(CCc2cccc(OCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		CHEMBL396349	151600	0	None	-8	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	692	18	0	8	7.1	COc1ccccc1N1CCN(CCc2cccc(OCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		46205700	124393	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	237	2	1	1	3.7	Cc1ccc(-c2ccccc2C2CCNC2)cc1	nan
		CHEMBL3639394	124393	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	237	2	1	1	3.7	Cc1ccc(-c2ccccc2C2CCNC2)cc1	nan
		46204088	124557	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	255	4	1	3	2.7	COc1ccc(-c2ccccc2)cc1OC1CNC1	nan
		CHEMBL3640564	124557	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	255	4	1	3	2.7	COc1ccc(-c2ccccc2)cc1OC1CNC1	nan
		46205697	124592	2	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	223	2	1	1	3.4	c1ccc(-c2ccccc2C2CCNC2)cc1	nan
		CHEMBL3640598	124592	2	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	223	2	1	1	3.4	c1ccc(-c2ccccc2C2CCNC2)cc1	nan
		46206344	124607	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	285	2	1	1	4.7	Cc1ccc(-c2ccc(Cl)cc2C2CCNC2)cc1C	nan
		CHEMBL3640612	124607	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	285	2	1	1	4.7	Cc1ccc(-c2ccc(Cl)cc2C2CCNC2)cc1C	nan
		46205700	124393	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	237	2	1	1	3.7	Cc1ccc(-c2ccccc2C2CCNC2)cc1	nan
		CHEMBL3639394	124393	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	237	2	1	1	3.7	Cc1ccc(-c2ccccc2C2CCNC2)cc1	nan
		46204088	124557	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	255	4	1	3	2.7	COc1ccc(-c2ccccc2)cc1OC1CNC1	nan
		CHEMBL3640564	124557	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	255	4	1	3	2.7	COc1ccc(-c2ccccc2)cc1OC1CNC1	nan
		46205697	124592	2	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	223	2	1	1	3.4	c1ccc(-c2ccccc2C2CCNC2)cc1	nan
		CHEMBL3640598	124592	2	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	223	2	1	1	3.4	c1ccc(-c2ccccc2C2CCNC2)cc1	nan
		46206344	124607	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	285	2	1	1	4.7	Cc1ccc(-c2ccc(Cl)cc2C2CCNC2)cc1C	nan
		CHEMBL3640612	124607	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	285	2	1	1	4.7	Cc1ccc(-c2ccc(Cl)cc2C2CCNC2)cc1C	nan
		162662361	181472	0	None	-20	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	465	8	1	6	4.0	COc1ccc2cc(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)ccc2c1	10.1016/j.ejmech.2020.112149
		CHEMBL4764557	181472	0	None	-20	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	465	8	1	6	4.0	COc1ccc2cc(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)ccc2c1	10.1016/j.ejmech.2020.112149
		2726	919	68	None	-13	72	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2013.12.024
		621	919	68	None	-13	72	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2013.12.024
		83	919	68	None	-13	72	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2013.12.024
		CHEMBL71	919	68	None	-13	72	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2013.12.024
		DB00477	919	68	None	-13	72	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2013.12.024
		15443	117810	96	None	-17	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2021.113243
		CHEMBL340211	117810	96	None	-17	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2021.113243
		15443	117810	96	None	-17	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
		CHEMBL340211	117810	96	None	-17	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
		44374206	52557	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	248	5	1	4	2.1	CN(C)CCSc1n[nH]c(-c2ccccc2)n1	10.1016/j.bmcl.2003.11.050
		CHEMBL159223	52557	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	248	5	1	4	2.1	CN(C)CCSc1n[nH]c(-c2ccccc2)n1	10.1016/j.bmcl.2003.11.050
		60364	106394	10	None	-19	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	264	4	0	2	3.7	CN(C)CCc1cn(-c2ccccc2)c2ccccc12	10.1016/j.ejmech.2014.01.055
		CHEMBL3121413	106394	10	None	-19	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	264	4	0	2	3.7	CN(C)CCc1cn(-c2ccccc2)c2ccccc12	10.1016/j.ejmech.2014.01.055
		CHEMBL3139439	106394	10	None	-19	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	264	4	0	2	3.7	CN(C)CCc1cn(-c2ccccc2)c2ccccc12	10.1016/j.ejmech.2014.01.055
		21557475	174889	0	None	-6	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	442	8	0	5	4.2	O=C1c2cccc3cccc(c23)C(=O)N1CCCCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2019.06.029
		CHEMBL4564093	174889	0	None	-6	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	442	8	0	5	4.2	O=C1c2cccc3cccc(c23)C(=O)N1CCCCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2019.06.029
		71602639	89681	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1cccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)c1	10.1016/j.bmc.2013.02.038
		CHEMBL2376449	89681	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1cccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)c1	10.1016/j.bmc.2013.02.038
		23661735	90988	0	None	-467	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	423	3	0	4	3.7	O=C1CCCC(=O)N1C1CCC(N2CCN(c3cccc(C(F)(F)F)c3)CC2)CC1	10.1016/j.bmc.2007.07.029
		CHEMBL239681	90988	0	None	-467	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	423	3	0	4	3.7	O=C1CCCC(=O)N1C1CCC(N2CCN(c3cccc(C(F)(F)F)c3)CC2)CC1	10.1016/j.bmc.2007.07.029
		145946271	167517	0	None	-3	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	495	7	2	6	2.5	N#Cc1ccccc1N1CCN(CC(O)CN2C(=O)NC(c3ccccc3)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
		CHEMBL4162548	167517	0	None	-3	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	495	7	2	6	2.5	N#Cc1ccccc1N1CCN(CC(O)CN2C(=O)NC(c3ccccc3)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
		CHEMBL4299919	167517	0	None	-3	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	495	7	2	6	2.5	N#Cc1ccccc1N1CCN(CC(O)CN2C(=O)NC(c3ccccc3)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
		145965840	164016	0	None	2	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	425	5	1	4	3.8	O=C1Nc2ccccc2C12CCN(CCN1CCC(Oc3ccc(Cl)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
		CHEMBL4208468	164016	0	None	2	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	425	5	1	4	3.8	O=C1Nc2ccccc2C12CCN(CCN1CCC(Oc3ccc(Cl)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
		71449642	81433	0	None	-1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	386	7	1	5	2.8	O=S(=O)(NC1CCN(CCOc2ccccc2)C1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159476	81433	0	None	-1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	386	7	1	5	2.8	O=S(=O)(NC1CCN(CCOc2ccccc2)C1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
		90654842	112644	0	None	-2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	478	10	0	5	4.2	COc1cccc(N2CCN(CCCCCN3C(=O)N(Cc4ccccc4)C(=O)C3(C)C)CC2)c1	10.1016/j.ejmech.2014.01.065
		CHEMBL3233670	112644	0	None	-2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	478	10	0	5	4.2	COc1cccc(N2CCN(CCCCCN3C(=O)N(Cc4ccccc4)C(=O)C3(C)C)CC2)c1	10.1016/j.ejmech.2014.01.065
		CHEMBL3302936	112644	0	None	-2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	478	10	0	5	4.2	COc1cccc(N2CCN(CCCCCN3C(=O)N(Cc4ccccc4)C(=O)C3(C)C)CC2)c1	10.1016/j.ejmech.2014.01.065
		118736374	118946	0	None	-13	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	559	8	0	9	4.0	Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccc(Cl)cc5)CC4)c(-c4ccccc4)cn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
		CHEMBL3423338	118946	0	None	-13	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	559	8	0	9	4.0	Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccc(Cl)cc5)CC4)c(-c4ccccc4)cn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
		11328878	136930	0	None	2	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	469	9	1	4	5.2	COc1cc(Cl)ccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
		CHEMBL374261	136930	0	None	2	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	469	9	1	4	5.2	COc1cc(Cl)ccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
		136118614	93064	0	None	-13	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)N/C(=C/c2c[nH]c3ccc(Br)cc23)C1=O	10.1016/j.bmc.2013.09.011
		CHEMBL2442276	93064	0	None	-13	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)N/C(=C/c2c[nH]c3ccc(Br)cc23)C1=O	10.1016/j.bmc.2013.09.011
		2843443	117932	18	None	1	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	380	2	0	2	5.3	Brc1ccc2c(c1)c1c3n2CCN(Cc2ccccc2)C3CCC1	10.1016/j.bmcl.2015.03.049
		CHEMBL3403336	117932	18	None	1	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	380	2	0	2	5.3	Brc1ccc2c(c1)c1c3n2CCN(Cc2ccccc2)C3CCC1	10.1016/j.bmcl.2015.03.049
		56850924	71522	0	None	-22	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	348	8	1	5	2.8	O=C1CSC(=O)N1CCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
		CHEMBL1926758	71522	0	None	-22	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	348	8	1	5	2.8	O=C1CSC(=O)N1CCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
		CHEMBL1962806	71522	0	None	-22	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	348	8	1	5	2.8	O=C1CSC(=O)N1CCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
		90654850	112646	0	None	2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	502	9	0	4	4.6	CC1(C)C(=O)N(Cc2ccc(F)cc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2F)CC1	10.1016/j.ejmech.2014.01.065
		CHEMBL3233674	112646	0	None	2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	502	9	0	4	4.6	CC1(C)C(=O)N(Cc2ccc(F)cc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2F)CC1	10.1016/j.ejmech.2014.01.065
		CHEMBL3302943	112646	0	None	2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	502	9	0	4	4.6	CC1(C)C(=O)N(Cc2ccc(F)cc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2F)CC1	10.1016/j.ejmech.2014.01.065
		156015194	177553	0	None	3	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	377	4	2	4	3.0	C#CCOc1c(OC)cc2c3c1-c1cc(NC(N)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
		CHEMBL4640332	177553	0	None	3	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	377	4	2	4	3.0	C#CCOc1c(OC)cc2c3c1-c1cc(NC(N)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
		10313351	10263	23	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	177	1	1	2	1.5	COc1cccc2c1C[C@H](N)CC2	10.1021/jm030826m
		CHEMBL1161324	10263	23	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	177	1	1	2	1.5	COc1cccc2c1C[C@H](N)CC2	10.1021/jm030826m
		42618253	181307	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	398	5	0	5	3.6	O=c1n(CCN2CCN(c3ccccc3)CC2)c2ccccc2n1-c1ccccc1	10.1016/j.bmcl.2009.02.008
		CHEMBL476248	181307	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	398	5	0	5	3.6	O=c1n(CCN2CCN(c3ccccc3)CC2)c2ccccc2n1-c1ccccc1	10.1016/j.bmcl.2009.02.008
		135367869	164734	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
		CHEMBL4217548	164734	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
		9419	35922	35	None	-616	6	Human	4.9	pKi	=	4.9	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1016/j.bmcl.2020.127493
		CHEMBL1442422	35922	35	None	-616	6	Human	4.9	pKi	=	4.9	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1016/j.bmcl.2020.127493
		126720440	163026	0	None	-2041	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	339	4	1	5	2.6	CCc1nc2c(N3CCNCC3)ccnc2n1Cc1cccc(F)c1	10.1016/j.ejmech.2017.12.053
		CHEMBL4175829	163026	0	None	-2041	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	339	4	1	5	2.6	CCc1nc2c(N3CCNCC3)ccnc2n1Cc1cccc(F)c1	10.1016/j.ejmech.2017.12.053
		71574300	86286	0	None	-5	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2ncccc2c1	10.1016/j.ejmech.2012.11.042
		CHEMBL2312937	86286	0	None	-5	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2ncccc2c1	10.1016/j.ejmech.2012.11.042
		155554325	176521	0	None	1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	447	8	0	3	5.8	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4548353	176521	0	None	1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	447	8	0	3	5.8	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4597000	176521	0	None	1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	447	8	0	3	5.8	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2019.06.028
		118736367	118939	0	None	-10	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	479	7	1	10	1.7	Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCCN1CCN(c2ccccc2O)CC1	10.1016/j.ejmech.2015.04.046
		CHEMBL3423331	118939	0	None	-10	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	479	7	1	10	1.7	Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCCN1CCN(c2ccccc2O)CC1	10.1016/j.ejmech.2015.04.046
		15599151	173939	0	None	-1621	5	Human	5.9	pKi	=	5.9	Binding	Inhibition of 5HT7R (unknown origin)Inhibition of 5HT7R (unknown origin)	ChEMBL	379	4	3	8	1.3	O[C@@H]1[C@@H](CCl)O[C@@H](n2cnc3c(N[C@H]4C[C@H]5CC[C@@H]4C5)ncnc32)[C@@H]1O	10.1021/acs.jmedchem.8b01662
		CHEMBL4541086	173939	0	None	-1621	5	Human	5.9	pKi	=	5.9	Binding	Inhibition of 5HT7R (unknown origin)Inhibition of 5HT7R (unknown origin)	ChEMBL	379	4	3	8	1.3	O[C@@H]1[C@@H](CCl)O[C@@H](n2cnc3c(N[C@H]4C[C@H]5CC[C@@H]4C5)ncnc32)[C@@H]1O	10.1021/acs.jmedchem.8b01662
		135367869	164734	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
		CHEMBL4217548	164734	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
		164614828	185269	0	None	-186	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	410	6	1	7	3.4	CCCC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
		CHEMBL4858771	185269	0	None	-186	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	410	6	1	7	3.4	CCCC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
		44268087	20194	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	374	6	0	3	4.0	CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm030030n
		CHEMBL13049	20194	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	374	6	0	3	4.0	CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm030030n
		44460641	105850	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	271	3	0	3	2.6	Cc1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
		CHEMBL312720	105850	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	271	3	0	3	2.6	Cc1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
		53370045	166433	7	None	3	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	376	6	2	6	0.5	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(C)C2=O)CC1	10.1039/C8MD00168E
		CHEMBL4277406	166433	7	None	3	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	376	6	2	6	0.5	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(C)C2=O)CC1	10.1039/C8MD00168E
		164614734	185396	0	None	-41	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	443	8	0	6	2.8	COc1ccccc1N1CCN(CCCCCN2C(=O)c3ccccc3S2(=O)=O)CC1	10.1016/j.bmcl.2021.128028
		CHEMBL4860754	185396	0	None	-41	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	443	8	0	6	2.8	COc1ccccc1N1CCN(CCCCCN2C(=O)c3ccccc3S2(=O)=O)CC1	10.1016/j.bmcl.2021.128028
		155546595	173543	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	586	10	1	6	5.8	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
		CHEMBL4531761	173543	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	586	10	1	6	5.8	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
		44424662	85780	0	None	-8	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	488	9	0	9	2.5	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2007.05.017
		CHEMBL229366	85780	0	None	-8	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	488	9	0	9	2.5	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2007.05.017
		11421024	84694	0	None	30	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	446	8	1	5	4.7	O=C(CCCCCN1CCN(c2noc3ccccc23)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
		CHEMBL222603	84694	0	None	30	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	446	8	1	5	4.7	O=C(CCCCCN1CCN(c2noc3ccccc23)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
		1346	83	117	None	-147	9	Rat	6.9	pKi	=	6.9	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	10.1021/jm030826m
		280	83	117	None	-147	9	Rat	6.9	pKi	=	6.9	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	10.1021/jm030826m
		9899402	83	117	None	-147	9	Rat	6.9	pKi	=	6.9	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	10.1021/jm030826m
		CHEMBL9666	83	117	None	-147	9	Rat	6.9	pKi	=	6.9	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	10.1021/jm030826m
		49850772	56399	0	None	-794	9	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	397	5	0	5	4.1	Cc1ccc2c(N3CCN(CCc4cccc(-n5cccn5)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1631545	56399	0	None	-794	9	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	397	5	0	5	4.1	Cc1ccc2c(N3CCN(CCc4cccc(-n5cccn5)c4)CC3)cccc2n1	10.1021/jm100714c
		10619437	16572	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	374	6	0	3	4.0	C[C@@H]1CCCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm970519e
		CHEMBL12389	16572	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	374	6	0	3	4.0	C[C@@H]1CCCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm970519e
		10619437	16572	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	C[C@@H]1CCCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1016/s0960-894x(00)00166-9
		CHEMBL12389	16572	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	C[C@@H]1CCCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1016/s0960-894x(00)00166-9
		44368683	45551	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	373	6	0	3	4.8	CC([C@H](C)CCN1CCC[C@@H](C)C1)S(=O)(=O)c1cccc2ccccc12	10.1021/jm030841r
		CHEMBL152873	45551	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	373	6	0	3	4.8	CC([C@H](C)CCN1CCC[C@@H](C)C1)S(=O)(=O)c1cccc2ccccc12	10.1021/jm030841r
		134156222	154351	0	None	-1	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	334	5	1	3	3.2	O=C1Cc2cc(C(=O)CCCN3CCc4ccccc4C3)ccc2N1	10.1016/j.bmc.2016.09.019
		CHEMBL3986927	154351	0	None	-1	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	334	5	1	3	3.2	O=C1Cc2cc(C(=O)CCCN3CCc4ccccc4C3)ccc2N1	10.1016/j.bmc.2016.09.019
		CHEMBL5073337	214292	0	None	-30	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		C[C@H]1C[C@H](NS(=O)(=O)c2cc3ccc(Cl)cc3s2)CN1CCCc1noc2cc(F)ccc12	10.1021/acs.jmedchem.1c00497
		CHEMBL5093017	215401	0	None	-35	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		C[C@H]1C[C@H](NS(=O)(=O)c2ccc(F)c(Cl)c2)CN1CCCc1noc2cc(F)ccc12	10.1021/acs.jmedchem.1c00497
		162657622	181137	0	None	-48	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	469	7	1	5	4.6	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2cc(Cl)ccc2c1	10.1016/j.ejmech.2020.112149
		CHEMBL4760655	181137	0	None	-48	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	469	7	1	5	4.6	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2cc(Cl)ccc2c1	10.1016/j.ejmech.2020.112149
		277	1301	62	None	-63	50	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1016/j.ejmech.2019.111705
		2913	1301	62	None	-63	50	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1016/j.ejmech.2019.111705
		765	1301	62	None	-63	50	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1016/j.ejmech.2019.111705
		CHEMBL516	1301	62	None	-63	50	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1016/j.ejmech.2019.111705
		DB00434	1301	62	None	-63	50	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1016/j.ejmech.2019.111705
		11248705	90295	0	None	-50	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
		CHEMBL238519	90295	0	None	-50	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
		11178830	148126	0	None	-79	9	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	467	6	1	5	4.5	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cc(F)cc2n1	10.1016/j.bmcl.2006.11.031
		CHEMBL393539	148126	0	None	-79	9	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	467	6	1	5	4.5	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cc(F)cc2n1	10.1016/j.bmcl.2006.11.031
		122483276	138113	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	439	8	0	4	5.8	O=C(CCCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3763677	138113	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	439	8	0	4	5.8	O=C(CCCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765878	138113	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	439	8	0	4	5.8	O=C(CCCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		60167451	75348	0	None	-1	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	468	7	1	6	5.3	O=C(CCCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
		CHEMBL2037520	75348	0	None	-1	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	468	7	1	6	5.3	O=C(CCCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
		145971527	163117	0	None	-7	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	337	7	1	2	5.6	Cc1ccc(C(C)NCCC(c2ccc(F)cc2)c2ccco2)cc1	10.1016/j.ejmech.2018.04.010
		CHEMBL4177293	163117	0	None	-7	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	337	7	1	2	5.6	Cc1ccc(C(C)NCCC(c2ccc(F)cc2)c2ccco2)cc1	10.1016/j.ejmech.2018.04.010
		57393878	68432	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	401	7	1	4	3.8	O=S(=O)(NCCCCN1CCC2CCCCC2C1)c1cccc2cccnc12	10.1016/j.bmc.2011.09.044
		CHEMBL1917353	68432	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	401	7	1	4	3.8	O=S(=O)(NCCCCN1CCC2CCCCC2C1)c1cccc2cccnc12	10.1016/j.bmc.2011.09.044
		164610188	185055	0	None	-194	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	382	4	1	7	2.7	CC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
		CHEMBL4855393	185055	0	None	-194	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	382	4	1	7	2.7	CC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
		1574	81	60	None	-13	21	Human	5.9	pKi	=	5.9	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	10.1021/jm030030n
		218	81	60	None	-13	21	Human	5.9	pKi	=	5.9	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	10.1021/jm030030n
		CHEMBL266591	81	60	None	-13	21	Human	5.9	pKi	=	5.9	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	10.1021/jm030030n
		11191906	11767	0	None	-25	12	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT	ChEMBL	537	12	1	3	7.3	O=C(/C=C/c1ccccc1)N(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)Cc1cccnc1	10.1016/j.bmcl.2005.06.024
		CHEMBL1181665	11767	0	None	-25	12	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT	ChEMBL	537	12	1	3	7.3	O=C(/C=C/c1ccccc1)N(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)Cc1cccnc1	10.1016/j.bmcl.2005.06.024
		CHEMBL187928	11767	0	None	-25	12	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT	ChEMBL	537	12	1	3	7.3	O=C(/C=C/c1ccccc1)N(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)Cc1cccnc1	10.1016/j.bmcl.2005.06.024
		71602639	89681	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1cccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)c1	10.1016/j.bmc.2013.02.038
		CHEMBL2376449	89681	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1cccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)c1	10.1016/j.bmc.2013.02.038
		155519891	170393	0	None	-5	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	249	2	1	4	1.9	COc1cc(OC)c2c(c1)OC[C@@]1(C)NCC[C@@H]21	10.1021/acsmedchemlett.9b00225
		CHEMBL4447975	170393	0	None	-5	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	249	2	1	4	1.9	COc1cc(OC)c2c(c1)OC[C@@]1(C)NCC[C@@H]21	10.1021/acsmedchemlett.9b00225
		153287568	170985	0	None	-15	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	217	0	1	2	2.5	Cc1cc(C)c2c(c1)OC[C@@]1(C)NCC[C@@H]21	10.1021/acsmedchemlett.9b00225
		CHEMBL4456195	170985	0	None	-15	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	217	0	1	2	2.5	Cc1cc(C)c2c(c1)OC[C@@]1(C)NCC[C@@H]21	10.1021/acsmedchemlett.9b00225
		1524	2181	96	None	-501	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2019.111705
		197	2181	96	None	-501	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2019.111705
		3822	2181	96	None	-501	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2019.111705
		88	2181	96	None	-501	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2019.111705
		CHEMBL51	2181	96	None	-501	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2019.111705
		DB12465	2181	96	None	-501	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2019.111705
		52952420	62591	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	377	5	1	5	4.0	N#Cc1ccc(N2CCN(CCC(O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
		CHEMBL1782808	62591	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	377	5	1	5	4.0	N#Cc1ccc(N2CCN(CCC(O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
		17374371	117926	9	None	-2	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	447	5	1	5	4.7	O=S(=O)(Nc1ccn(Cc2cccc3ccccc23)n1)c1ccc(Br)s1	10.1016/j.bmcl.2015.03.049
		CHEMBL3403330	117926	9	None	-2	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	447	5	1	5	4.7	O=S(=O)(Nc1ccn(Cc2cccc3ccccc23)n1)c1ccc(Br)s1	10.1016/j.bmcl.2015.03.049
		57399868	71556	0	None	39	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	444	7	1	5	3.4	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
		CHEMBL1949978	71556	0	None	39	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	444	7	1	5	3.4	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
		CHEMBL1963032	71556	0	None	39	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	444	7	1	5	3.4	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
		134140472	146021	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	241	4	0	2	3.4	COc1ccccc1-c1cccc(CN(C)C)c1	10.1016/j.ejmech.2016.07.029
		CHEMBL3918663	146021	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	241	4	0	2	3.4	COc1ccccc1-c1cccc(CN(C)C)c1	10.1016/j.ejmech.2016.07.029
		49756	204312	13	None	-5	8	Human	5.9	pKi	=	5.9	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	232	4	1	2	2.6	COc1ccc2[nH]c(C)c(CCN(C)C)c2c1	10.1021/jm030030n
		CHEMBL7143	204312	13	None	-5	8	Human	5.9	pKi	=	5.9	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	232	4	1	2	2.6	COc1ccc2[nH]c(C)c(CCN(C)C)c2c1	10.1021/jm030030n
		46204731	124570	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	318	3	1	3	3.6	N#Cc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
		CHEMBL3640577	124570	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	318	3	1	3	3.6	N#Cc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
		46204731	124570	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	318	3	1	3	3.6	N#Cc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
		CHEMBL3640577	124570	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	318	3	1	3	3.6	N#Cc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
		134156222	154351	0	None	-1	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	334	5	1	3	3.2	O=C1Cc2cc(C(=O)CCCN3CCc4ccccc4C3)ccc2N1	10.1016/j.bmc.2016.09.019
		CHEMBL3986927	154351	0	None	-1	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	334	5	1	3	3.2	O=C1Cc2cc(C(=O)CCCN3CCc4ccccc4C3)ccc2N1	10.1016/j.bmc.2016.09.019
		122483276	138113	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	439	8	0	4	5.8	O=C(CCCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3763677	138113	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	439	8	0	4	5.8	O=C(CCCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765878	138113	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	439	8	0	4	5.8	O=C(CCCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		60167451	75348	0	None	-1	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	468	7	1	6	5.3	O=C(CCCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
		CHEMBL2037520	75348	0	None	-1	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	468	7	1	6	5.3	O=C(CCCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
		60167451	75348	0	None	-1	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	468	7	1	6	5.3	O=C(CCCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
		CHEMBL2037520	75348	0	None	-1	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	468	7	1	6	5.3	O=C(CCCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
		22425072	117940	7	None	-1	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	457	5	0	4	6.5	Cc1ccc(S(=O)(=O)c2cnc3ccc(F)cc3c2SCc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2015.03.049
		CHEMBL3403343	117940	7	None	-1	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	457	5	0	4	6.5	Cc1ccc(S(=O)(=O)c2cnc3ccc(F)cc3c2SCc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2015.03.049
		122442272	138348	0	None	-40	15	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human 5HT7 receptor by radioligand binding assayBinding affinity to human 5HT7 receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
		CHEMBL3769968	138348	0	None	-40	15	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human 5HT7 receptor by radioligand binding assayBinding affinity to human 5HT7 receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
		CHEMBL3771384	138348	0	None	-40	15	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human 5HT7 receptor by radioligand binding assayBinding affinity to human 5HT7 receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
		137646281	157806	0	None	-295	17	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	423	8	0	7	3.8	COc1ccccc1N1CCN(CCCSc2nnc(-c3ccccc3)n2C)CC1	10.1021/acs.jmedchem.9b00412
		CHEMBL4083252	157806	0	None	-295	17	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	423	8	0	7	3.8	COc1ccccc1N1CCN(CCCSc2nnc(-c3ccccc3)n2C)CC1	10.1021/acs.jmedchem.9b00412
		46233350	200300	0	None	7	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	286	5	0	3	4.0	Cc1cccc(C)c1-c1cccc(SCCN(C)C)n1	10.1016/j.bmc.2010.01.035
		CHEMBL597357	200300	0	None	7	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	286	5	0	3	4.0	Cc1cccc(C)c1-c1cccc(SCCN(C)C)n1	10.1016/j.bmc.2010.01.035
		4723431	171423	14	None	-14	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	316	6	2	2	4.8	c1ccc(-c2ccc(CNCCc3c[nH]c4ccccc34)o2)cc1	10.1016/j.ejmech.2019.111857
		CHEMBL4462814	171423	14	None	-14	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	316	6	2	2	4.8	c1ccc(-c2ccc(CNCCc3c[nH]c4ccccc34)o2)cc1	10.1016/j.ejmech.2019.111857
		122483231	138087	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	336	8	0	3	5.3	CCCCN(C)CCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765208	138087	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	336	8	0	3	5.3	CCCCN(C)CCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765835	138087	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	336	8	0	3	5.3	CCCCN(C)CCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		122483231	138087	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	336	8	0	3	5.3	CCCCN(C)CCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765208	138087	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	336	8	0	3	5.3	CCCCN(C)CCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765835	138087	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	336	8	0	3	5.3	CCCCN(C)CCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		11443608	143730	0	None	1	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	8	1	5	3.8	COc1ccc2c(c1)C(NC(=O)CCCN1CCN(c3ccccc3OC)CC1)CCC2	10.1021/jm049702f
		CHEMBL390062	143730	0	None	1	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	8	1	5	3.8	COc1ccc2c(c1)C(NC(=O)CCCN1CCN(c3ccccc3OC)CC1)CCC2	10.1021/jm049702f
		46205695	124590	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	253	3	1	2	3.4	COc1ccc(-c2ccccc2)cc1C1CCNC1	nan
		CHEMBL3640596	124590	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	253	3	1	2	3.4	COc1ccc(-c2ccccc2)cc1C1CCNC1	nan
		46206025	124605	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	291	2	1	1	4.7	Clc1cccc(-c2ccc(Cl)cc2C2CCNC2)c1	nan
		CHEMBL3640610	124605	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	291	2	1	1	4.7	Clc1cccc(-c2ccc(Cl)cc2C2CCNC2)c1	nan
		46205695	124590	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	253	3	1	2	3.4	COc1ccc(-c2ccccc2)cc1C1CCNC1	nan
		CHEMBL3640596	124590	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	253	3	1	2	3.4	COc1ccc(-c2ccccc2)cc1C1CCNC1	nan
		46206025	124605	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	291	2	1	1	4.7	Clc1cccc(-c2ccc(Cl)cc2C2CCNC2)c1	nan
		CHEMBL3640610	124605	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	291	2	1	1	4.7	Clc1cccc(-c2ccc(Cl)cc2C2CCNC2)c1	nan
		44393021	65050	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	317	7	2	3	4.9	C[C@H](Nc1cncc(NCCc2ccccc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		CHEMBL182356	65050	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	317	7	2	3	4.9	C[C@H](Nc1cncc(NCCc2ccccc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		154926540	190324	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	Binding affinity to rat 5-HT7 receptor assessed as inhibition constantBinding affinity to rat 5-HT7 receptor assessed as inhibition constant	ChEMBL	439	10	1	4	4.6	CCC1(CCCCN2CCN(c3cccc(OCCF)c3)CC2)C(=O)Nc2ccccc21	10.1021/acs.jmedchem.2c00633
		CHEMBL5176380	190324	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	Binding affinity to rat 5-HT7 receptor assessed as inhibition constantBinding affinity to rat 5-HT7 receptor assessed as inhibition constant	ChEMBL	439	10	1	4	4.6	CCC1(CCCCN2CCN(c3cccc(OCCF)c3)CC2)C(=O)Nc2ccccc21	10.1021/acs.jmedchem.2c00633
		54764323	68438	0	None	85	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	429	8	0	4	4.5	CCN(CCCCN1CCC2CCCCC2C1)S(=O)(=O)c1cccc2cccnc12	10.1016/j.bmc.2011.09.044
		CHEMBL1917359	68438	0	None	85	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	429	8	0	4	4.5	CCN(CCCCN1CCC2CCCCC2C1)S(=O)(=O)c1cccc2cccnc12	10.1016/j.bmc.2011.09.044
		127040908	137073	0	None	3	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	434	8	0	4	4.1	CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2015.11.041
		CHEMBL3747071	137073	0	None	3	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	434	8	0	4	4.1	CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2015.11.041
		71449641	81414	0	None	3	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	468	9	1	4	4.6	O=S(=O)(NCC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159458	81414	0	None	3	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	468	9	1	4	4.6	O=S(=O)(NCC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
		60196073	81815	0	None	2	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	283	3	1	4	2.7	O=[N+]([O-])c1ccc(-c2cccc(N3CCNCC3)c2)cc1	10.1021/jm3003679
		CHEMBL2164339	81815	0	None	2	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	283	3	1	4	2.7	O=[N+]([O-])c1ccc(-c2cccc(N3CCNCC3)c2)cc1	10.1021/jm3003679
		10571274	99459	0	None	42	3	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	371	3	0	3	5.1	COc1cccc(OC)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0108505
		CHEMBL283065	99459	0	None	42	3	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	371	3	0	3	5.1	COc1cccc(OC)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0108505
		44408816	76578	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	397	8	0	3	5.0	O=S(=O)(c1ccccc1)C1(CCCCN2CCC(c3ccccc3)C2)CCC1	10.1016/j.bmcl.2005.11.067
		CHEMBL206305	76578	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	397	8	0	3	5.0	O=S(=O)(c1ccccc1)C1(CCCCN2CCC(c3ccccc3)C2)CCC1	10.1016/j.bmcl.2005.11.067
		54758392	66005	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	398	6	1	2	5.5	O=C1Nc2cc(F)ccc2C1CCCCN1CC=C(c2cccc(Cl)c2)CC1	10.1021/jm200547z
		CHEMBL1836794	66005	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	398	6	1	2	5.5	O=C1Nc2cc(F)ccc2C1CCCCN1CC=C(c2cccc(Cl)c2)CC1	10.1021/jm200547z
		66801000	112062	0	None	-1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	472	7	1	7	4.0	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
		CHEMBL3289957	112062	0	None	-1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	472	7	1	7	4.0	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
		56944473	112128	0	None	-1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	488	8	1	7	4.5	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
		CHEMBL3290021	112128	0	None	-1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	488	8	1	7	4.5	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
		9839050	112379	0	None	-26	9	Human	7.9	pKi	=	7.9	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	293	2	0	2	3.8	CN(C)C[C@H]1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1	10.1021/jm049632c
		CHEMBL329566	112379	0	None	-26	9	Human	7.9	pKi	=	7.9	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	293	2	0	2	3.8	CN(C)C[C@H]1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1	10.1021/jm049632c
		162664534	182102	0	None	14	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	418	9	0	6	4.1	COc1ccc(-c2ccccc2N2CCN(CCCCOc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
		CHEMBL4781863	182102	0	None	14	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	418	9	0	6	4.1	COc1ccc(-c2ccccc2N2CCN(CCCCOc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
		90656691	110988	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	323	7	1	4	3.1	O=Cc1cccc(NCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262421	110988	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	323	7	1	4	3.1	O=Cc1cccc(NCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
		135458394	97691	5	None	-2	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	243	0	2	3	2.9	CNC1=Nc2ccc(Cl)c(Cl)c2C(C)N1	10.1016/j.bmcl.2007.10.080
		CHEMBL271298	97691	5	None	-2	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	243	0	2	3	2.9	CNC1=Nc2ccc(Cl)c(Cl)c2C(C)N1	10.1016/j.bmcl.2007.10.080
		11173572	129907	0	None	-1	2	Rat	7.9	pKi	=	7.9	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	281	2	0	2	3.8	Cc1cccc(C)c1-c1ccc2c(c1)C[C@H](N(C)C)CO2	10.1016/j.bmcl.2004.11.013
		CHEMBL367584	129907	0	None	-1	2	Rat	7.9	pKi	=	7.9	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	281	2	0	2	3.8	Cc1cccc(C)c1-c1ccc2c(c1)C[C@H](N(C)C)CO2	10.1016/j.bmcl.2004.11.013
		10706626	99133	0	None	1	6	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	262	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@H]3N	10.1021/jm030030n
		CHEMBL281048	99133	0	None	1	6	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	262	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@H]3N	10.1021/jm030030n
		10706626	99133	0	None	-1	6	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	262	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@H]3N	10.1021/jm9911433
		CHEMBL281048	99133	0	None	-1	6	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	262	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@H]3N	10.1021/jm9911433
		11173572	129907	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	281	2	0	2	3.8	Cc1cccc(C)c1-c1ccc2c(c1)C[C@H](N(C)C)CO2	10.1016/j.bmc.2010.01.035
		CHEMBL367584	129907	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	281	2	0	2	3.8	Cc1cccc(C)c1-c1ccc2c(c1)C[C@H](N(C)C)CO2	10.1016/j.bmc.2010.01.035
		46203760	124549	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2ccccc2C)cc1OC1CNC1	nan
		CHEMBL3640557	124549	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2ccccc2C)cc1OC1CNC1	nan
		46203760	124549	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2ccccc2C)cc1OC1CNC1	nan
		CHEMBL3640557	124549	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2ccccc2C)cc1OC1CNC1	nan
		10730269	97103	0	None	1	4	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	263	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@H]3O	10.1021/jm9911433
		CHEMBL26751	97103	0	None	1	4	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	263	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@H]3O	10.1021/jm9911433
		135895192	172211	0	None	85	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	418	6	1	5	4.3	O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
		CHEMBL4473885	172211	0	None	85	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	418	6	1	5	4.3	O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
		122181341	121883	0	None	-42	3	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	490	8	1	5	4.2	COc1ccccc1N1CCN(CCCCN2C(=O)NC3(CCC(c4ccccc4)CC3)C2=O)CC1	10.1016/j.bmc.2015.04.026
		CHEMBL3590093	121883	0	None	-42	3	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	490	8	1	5	4.2	COc1ccccc1N1CCN(CCCCN2C(=O)NC3(CCC(c4ccccc4)CC3)C2=O)CC1	10.1016/j.bmc.2015.04.026
		162672061	183763	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	7	1	4	4.5	COc1ccccc1N1CCN(CCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4793191	183763	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	7	1	4	4.5	COc1ccccc1N1CCN(CCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4803857	183763	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	7	1	4	4.5	COc1ccccc1N1CCN(CCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
		44424654	85754	0	None	1	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	460	7	0	9	1.7	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2007.05.017
		CHEMBL229123	85754	0	None	1	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	460	7	0	9	1.7	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2007.05.017
		9867475	18013	0	None	-426	9	Human	5.9	pKi	=	5.9	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	432	7	0	5	4.2	CN(C)CCc1cccc2c1cc(C(=O)c1ccccc1)n2S(=O)(=O)c1ccccc1	10.1021/jm010943m
		CHEMBL126340	18013	0	None	-426	9	Human	5.9	pKi	=	5.9	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	432	7	0	5	4.2	CN(C)CCc1cccc2c1cc(C(=O)c1ccccc1)n2S(=O)(=O)c1ccccc1	10.1021/jm010943m
		2870750	117930	7	None	-2	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	442	4	1	5	6.0	Nc1c(S(=O)(=O)c2ccccc2)sc2nc(-c3ccccc3)cc(-c3ccccc3)c12	10.1016/j.bmcl.2015.03.049
		CHEMBL3403334	117930	7	None	-2	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	442	4	1	5	6.0	Nc1c(S(=O)(=O)c2ccccc2)sc2nc(-c3ccccc3)cc(-c3ccccc3)c12	10.1016/j.bmcl.2015.03.049
		122483238	138104	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	6	0	4	4.3	O=C(CCCCCN1CCOCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3763567	138104	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	6	0	4	4.3	O=C(CCCCCN1CCOCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765853	138104	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	6	0	4	4.3	O=C(CCCCCN1CCOCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		24768524	93202	0	None	-4	3	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	423	8	1	3	4.7	O=C(CCCCCN1CCN(c2ccccc2F)CC1)NC1CCCc2ccccc21	10.1021/jm070487n
		CHEMBL244577	93202	0	None	-4	3	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	423	8	1	3	4.7	O=C(CCCCCN1CCN(c2ccccc2F)CC1)NC1CCCc2ccccc21	10.1021/jm070487n
		13069627	120613	0	None	-26	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	444	7	0	8	2.1	Cn1c(=O)c2c(ncn2CCCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		CHEMBL3361001	120613	0	None	-26	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	444	7	0	8	2.1	Cn1c(=O)c2c(ncn2CCCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		CHEMBL3546113	120613	0	None	-26	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	444	7	0	8	2.1	Cn1c(=O)c2c(ncn2CCCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		134136246	142538	0	None	-1	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	275	3	0	1	4.1	C1=C(CCN2CCc3ccccc3C2)Cc2ccccc21	10.1016/j.bmc.2016.09.019
		CHEMBL3890841	142538	0	None	-1	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	275	3	0	1	4.1	C1=C(CCN2CCc3ccccc3C2)Cc2ccccc21	10.1016/j.bmc.2016.09.019
		162663078	181994	0	None	-46	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	489	7	1	6	5.0	Cc1c(S(=O)(=O)N[C@@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(Cl)cc12	10.1016/j.ejmech.2020.112149
		CHEMBL4780470	181994	0	None	-46	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	489	7	1	6	5.0	Cc1c(S(=O)(=O)N[C@@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(Cl)cc12	10.1016/j.ejmech.2020.112149
		134130594	142244	0	None	-7	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	436	8	0	5	4.6	O=c1cc(-c2ccccc2)ncn1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2016.12.039
		CHEMBL3884728	142244	0	None	-7	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	436	8	0	5	4.6	O=c1cc(-c2ccccc2)ncn1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2016.12.039
		16763549	117941	9	None	-4	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	342	5	1	5	2.8	COCCn1c(C)c(C)c(S(=O)(=O)c2ccc(Cl)cc2)c1N	10.1016/j.bmcl.2015.03.049
		CHEMBL3403344	117941	9	None	-4	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	342	5	1	5	2.8	COCCn1c(C)c(C)c(S(=O)(=O)c2ccc(Cl)cc2)c1N	10.1016/j.bmcl.2015.03.049
		90654697	110083	0	None	-5	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	406	8	1	4	2.5	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235734	110083	0	None	-5	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	406	8	1	4	2.5	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.ejmech.2014.03.005
		122483238	138104	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	6	0	4	4.3	O=C(CCCCCN1CCOCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3763567	138104	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	6	0	4	4.3	O=C(CCCCCN1CCOCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765853	138104	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	6	0	4	4.3	O=C(CCCCCN1CCOCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		57397410	68422	0	None	-3	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	454	9	1	6	3.1	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc3ncccc3c2)CC1	10.1016/j.bmc.2011.09.044
		CHEMBL1917343	68422	0	None	-3	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	454	9	1	6	3.1	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc3ncccc3c2)CC1	10.1016/j.bmc.2011.09.044
		134136246	142538	0	None	-1	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	275	3	0	1	4.1	C1=C(CCN2CCc3ccccc3C2)Cc2ccccc21	10.1016/j.bmc.2016.09.019
		CHEMBL3890841	142538	0	None	-1	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	275	3	0	1	4.1	C1=C(CCN2CCc3ccccc3C2)Cc2ccccc21	10.1016/j.bmc.2016.09.019
		156010584	177079	0	None	-17	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	335	2	1	4	4.4	CCCN1CCc2cccc3c2C1Cc1cc2sc(N)nc2cc1-3	10.1016/j.bmc.2020.115578
		CHEMBL4633042	177079	0	None	-17	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	335	2	1	4	4.4	CCCN1CCc2cccc3c2C1Cc1cc2sc(N)nc2cc1-3	10.1016/j.bmc.2020.115578
		56649648	67855	0	None	-398	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	474	8	0	5	3.0	COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52CF)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
		CHEMBL1910139	67855	0	None	-398	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	474	8	0	5	3.0	COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52CF)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
		10780842	97904	0	None	-1	5	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	304	1	1	2	3.0	CC(=O)N[C@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
		CHEMBL27247	97904	0	None	-1	5	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	304	1	1	2	3.0	CC(=O)N[C@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
		134131151	142236	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	416	9	0	5	3.9	O=c1cc(-c2ccccc2)ncn1CCCCCN1CCN(Cc2ccccc2)CC1	10.1016/j.bmc.2016.12.039
		CHEMBL3884634	142236	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	416	9	0	5	3.9	O=c1cc(-c2ccccc2)ncn1CCCCCN1CCN(Cc2ccccc2)CC1	10.1016/j.bmc.2016.12.039
		155538877	172793	0	None	3	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	382	7	1	5	3.1	O=c1[nH]c(CCCCN2CCN(Cc3ccccc3)CC2)nc2ccsc12	10.1016/j.ejmech.2019.111690
		CHEMBL4513482	172793	0	None	3	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	382	7	1	5	3.1	O=c1[nH]c(CCCCN2CCN(Cc3ccccc3)CC2)nc2ccsc12	10.1016/j.ejmech.2019.111690
		1524	2181	96	None	-501	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm030030n
		197	2181	96	None	-501	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm030030n
		3822	2181	96	None	-501	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm030030n
		88	2181	96	None	-501	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm030030n
		CHEMBL51	2181	96	None	-501	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm030030n
		DB12465	2181	96	None	-501	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm030030n
		164618028	185343	0	None	-9	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	352	7	1	4	3.2	CC(=O)Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
		CHEMBL4859988	185343	0	None	-9	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	352	7	1	4	3.2	CC(=O)Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
		42618270	91198	0	None	-22	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	435	6	0	4	3.8	O=C1C2=C(CCCC2)C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2007.07.029
		CHEMBL239897	91198	0	None	-22	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	435	6	0	4	3.8	O=C1C2=C(CCCC2)C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2007.07.029
		164618028	185343	0	None	-9	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	352	7	1	4	3.2	CC(=O)Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
		CHEMBL4859988	185343	0	None	-9	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	352	7	1	4	3.2	CC(=O)Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
		162671033	183755	0	None	-4	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2cccnc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
		CHEMBL4793296	183755	0	None	-4	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2cccnc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
		CHEMBL4803797	183755	0	None	-4	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2cccnc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
		145985958	165610	0	None	-112	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	1	7	3.0	O=c1[nH]c2c(N3CCN(CC[C@H]4CCCN4S(=O)(=O)c4cncc5ccccc45)CC3)cccc2o1	10.1016/j.ejmech.2018.01.002
		CHEMBL4243036	165610	0	None	-112	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	1	7	3.0	O=c1[nH]c2c(N3CCN(CC[C@H]4CCCN4S(=O)(=O)c4cncc5ccccc45)CC3)cccc2o1	10.1016/j.ejmech.2018.01.002
		18137017	163528	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2cccc(Cl)c2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
		CHEMBL4202769	163528	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2cccc(Cl)c2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
		164624246	185943	0	None	-158	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	410	6	1	7	3.4	CCCC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
		CHEMBL4869411	185943	0	None	-158	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	410	6	1	7	3.4	CCCC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
		10042333	163474	1	None	-831	3	Human	5.9	pKi	=	5.9	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	331	5	1	2	4.0	OC(c1ccc(F)cc1)C1CCN(CCc2ccc(F)cc2)CC1	10.1021/jm0200411
		CHEMBL420010	163474	1	None	-831	3	Human	5.9	pKi	=	5.9	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	331	5	1	2	4.0	OC(c1ccc(F)cc1)C1CCN(CCc2ccc(F)cc2)CC1	10.1021/jm0200411
		118731355	118191	0	None	-7	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	498	10	0	5	3.7	CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(=O)N2CCOCC2)CC1	10.1016/j.ejmech.2014.12.041
		CHEMBL3409038	118191	0	None	-7	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	498	10	0	5	3.7	CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(=O)N2CCOCC2)CC1	10.1016/j.ejmech.2014.12.041
		90654844	112624	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	466	9	0	4	4.4	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccccc2F)CC1	10.1016/j.ejmech.2014.01.065
		CHEMBL3233671	112624	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	466	9	0	4	4.4	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccccc2F)CC1	10.1016/j.ejmech.2014.01.065
		CHEMBL3302598	112624	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	466	9	0	4	4.4	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccccc2F)CC1	10.1016/j.ejmech.2014.01.065
		71727067	91266	0	None	-8	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	414	5	0	5	4.3	COc1ccc2c(=O)c3cc(CN4CCN(Cc5ccccc5)CC4)ccc3oc2c1	10.1016/j.bmcl.2013.05.062
		CHEMBL2401937	91266	0	None	-8	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	414	5	0	5	4.3	COc1ccc2c(=O)c3cc(CN4CCN(Cc5ccccc5)CC4)ccc3oc2c1	10.1016/j.bmcl.2013.05.062
		CHEMBL3217036	91266	0	None	-8	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	414	5	0	5	4.3	COc1ccc2c(=O)c3cc(CN4CCN(Cc5ccccc5)CC4)ccc3oc2c1	10.1016/j.bmcl.2013.05.062
		155524491	170956	0	None	-169	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	530	7	1	5	5.8	O=c1c(-c2ccccc2Cl)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
		CHEMBL4455658	170956	0	None	-169	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	530	7	1	5	5.8	O=c1c(-c2ccccc2Cl)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
		71458648	81415	0	None	-1	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	410	8	1	4	3.0	O=S(=O)(NCC1CCN(CCOc2cccc(F)c2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159459	81415	0	None	-1	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	410	8	1	4	3.0	O=S(=O)(NCC1CCN(CCOc2cccc(F)c2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
		118736364	118936	0	None	-676	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	451	6	1	10	1.0	Cn1c(=O)c2c(nc3n(CCCCN4CCN(c5ccccc5O)CC4)ccn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
		CHEMBL3423328	118936	0	None	-676	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	451	6	1	10	1.0	Cn1c(=O)c2c(nc3n(CCCCN4CCN(c5ccccc5O)CC4)ccn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
		90656706	112610	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	443	11	1	4	5.8	Oc1cccc(N(CCCCCCN2CCN(c3ccccc3)CC2)Cc2ccccc2)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262436	112610	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	443	11	1	4	5.8	Oc1cccc(N(CCCCCCN2CCN(c3ccccc3)CC2)Cc2ccccc2)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3302236	112610	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	443	11	1	4	5.8	Oc1cccc(N(CCCCCCN2CCN(c3ccccc3)CC2)Cc2ccccc2)c1	10.1016/j.ejmech.2014.04.034
		155516118	170039	3	None	-549	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	351	6	3	4	4.0	Oc1ccc(-c2ccc(CNCCc3c[nH]c4ncc(F)cc34)o2)cc1	10.1016/j.ejmech.2019.111857
		CHEMBL4442855	170039	3	None	-549	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	351	6	3	4	4.0	Oc1ccc(-c2ccc(CNCCc3c[nH]c4ncc(F)cc34)o2)cc1	10.1016/j.ejmech.2019.111857
		134131015	142305	0	None	-15	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	436	9	0	5	5.2	Clc1ccc(N2CCN(CCCCCOc3cc(-c4ccccc4)ncn3)CC2)cc1	10.1016/j.bmc.2016.12.039
		CHEMBL3885282	142305	0	None	-15	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	436	9	0	5	5.2	Clc1ccc(N2CCN(CCCCCOc3cc(-c4ccccc4)ncn3)CC2)cc1	10.1016/j.bmc.2016.12.039
		155569396	176138	0	None	10	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	279	2	1	2	4.1	CCn1cncc1-c1c[nH]c2ccc(C(F)(F)F)cc12	10.1016/j.ejmech.2019.03.017
		CHEMBL4592256	176138	0	None	10	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	279	2	1	2	4.1	CCn1cncc1-c1c[nH]c2ccc(C(F)(F)F)cc12	10.1016/j.ejmech.2019.03.017
		134144304	154493	0	None	-2	9	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.4	O=C(CCCN1CCc2ccccc2CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
		CHEMBL3952251	154493	0	None	-2	9	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.4	O=C(CCCN1CCc2ccccc2CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
		CHEMBL3990525	154493	0	None	-2	9	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.4	O=C(CCCN1CCc2ccccc2CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
		168281650	191202	0	None	2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	467	6	0	7	3.9	COc1cc2ncnc(N3CCC(CN4CCN(c5ccc(Cl)cc5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
		CHEMBL5189417	191202	0	None	2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	467	6	0	7	3.9	COc1cc2ncnc(N3CCC(CN4CCN(c5ccc(Cl)cc5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
		155533850	171892	0	None	-45	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	530	7	1	5	5.8	O=c1c(-c2ccc(Cl)cc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
		CHEMBL4469633	171892	0	None	-45	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	530	7	1	5	5.8	O=c1c(-c2ccc(Cl)cc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
		44460701	205265	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	302	4	0	5	2.2	CN1CCCN(CCn2ccc3ccc([N+](=O)[O-])cc32)CC1	10.1016/s0960-894x(02)00438-9
		CHEMBL78977	205265	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	302	4	0	5	2.2	CN1CCCN(CCn2ccc3ccc([N+](=O)[O-])cc32)CC1	10.1016/s0960-894x(02)00438-9
		54758294	65998	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3ccc(Cl)cc3Cl)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
		CHEMBL1836787	65998	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3ccc(Cl)cc3Cl)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
		44424667	85723	0	None	-3	2	Rat	4.9	pKi	=	4.9	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	398	5	1	8	-0.1	Cn1c(=O)c2c([nH]c(=O)n2CCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2007.05.017
		CHEMBL228938	85723	0	None	-3	2	Rat	4.9	pKi	=	4.9	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	398	5	1	8	-0.1	Cn1c(=O)c2c([nH]c(=O)n2CCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2007.05.017
		122483254	138096	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	5	0	3	5.6	CC1CC(C)CN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
		CHEMBL3764307	138096	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	5	0	3	5.6	CC1CC(C)CN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
		CHEMBL3765844	138096	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	5	0	3	5.6	CC1CC(C)CN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
		10472143	119277	0	None	-31	16	Human	7.9	pKi	=	7.9	Binding	Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		CHEMBL343755	119277	0	None	-31	16	Human	7.9	pKi	=	7.9	Binding	Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		53324535	57007	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	323	3	1	3	3.9	Clc1ccc(-c2nn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
		CHEMBL1644267	57007	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	323	3	1	3	3.9	Clc1ccc(-c2nn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
		242	470	124	None	-15	51	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm030030n
		34	470	124	None	-15	51	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm030030n
		60795	470	124	None	-15	51	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm030030n
		CHEMBL1112	470	124	None	-15	51	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm030030n
		DB01238	470	124	None	-15	51	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm030030n
		44461070	205637	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	363	4	0	3	3.8	CC(C)N1CCCN(CCn2ccc3ccc(Br)cc32)CC1	10.1016/s0960-894x(02)00438-9
		CHEMBL81784	205637	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	363	4	0	3	3.8	CC(C)N1CCCN(CCn2ccc3ccc(Br)cc32)CC1	10.1016/s0960-894x(02)00438-9
		137642134	158341	0	None	10	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	482	6	0	5	4.0	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccc(F)cc3)CC2)CC1	10.1016/j.bmc.2017.04.046
		CHEMBL4089427	158341	0	None	10	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	482	6	0	5	4.0	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccc(F)cc3)CC2)CC1	10.1016/j.bmc.2017.04.046
		127028473	138273	0	None	22	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	451	6	2	6	1.6	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2016.02.024
		CHEMBL3770639	138273	0	None	22	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	451	6	2	6	1.6	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2016.02.024
		127026451	137763	0	None	12	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	480	8	1	4	4.8	O=S(=O)(NC1CC2CCC(C1)N2CCOc1cccc(-c2ccccc2)c1)c1ccc(F)cc1	10.1016/j.ejmech.2015.11.040
		CHEMBL3759342	137763	0	None	12	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	480	8	1	4	4.8	O=S(=O)(NC1CC2CCC(C1)N2CCOc1cccc(-c2ccccc2)c1)c1ccc(F)cc1	10.1016/j.ejmech.2015.11.040
		127026752	137795	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	392	8	1	4	3.0	CC(C)c1ccccc1OCCN1CC(NS(=O)(=O)c2cccc(F)c2)C1	10.1016/j.ejmech.2015.11.040
		CHEMBL3759577	137795	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	392	8	1	4	3.0	CC(C)c1ccccc1OCCN1CC(NS(=O)(=O)c2cccc(F)c2)C1	10.1016/j.ejmech.2015.11.040
		127026133	137821	0	None	6	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	496	8	1	4	5.4	O=S(=O)(NC1CC2CCC(C1)N2CCOc1cccc(-c2ccccc2)c1)c1cccc(Cl)c1	10.1016/j.ejmech.2015.11.040
		CHEMBL3759819	137821	0	None	6	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	496	8	1	4	5.4	O=S(=O)(NC1CC2CCC(C1)N2CCOc1cccc(-c2ccccc2)c1)c1cccc(Cl)c1	10.1016/j.ejmech.2015.11.040
		145983128	165825	0	None	-2	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	489	6	1	5	4.1	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3[nH]ccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4248597	165825	0	None	-2	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	489	6	1	5	4.1	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3[nH]ccc23)CC1	10.1016/j.ejmech.2018.01.002
		134155645	151073	0	None	7	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	455	10	1	3	5.7	C[C@@H]1CN(c2ccccc2-c2ccccc2)CCN1CCCCCC(=O)NCc1ccccc1	10.1016/j.ejmech.2016.05.005
		CHEMBL3958956	151073	0	None	7	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	455	10	1	3	5.7	C[C@@H]1CN(c2ccccc2-c2ccccc2)CCN1CCCCCC(=O)NCc1ccccc1	10.1016/j.ejmech.2016.05.005
		71458650	81431	0	None	1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	454	7	1	5	4.1	O=S(=O)(NC1CCN(CCOc2cccc(Cl)c2Cl)C1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159474	81431	0	None	1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	454	7	1	5	4.1	O=S(=O)(NC1CCN(CCOc2cccc(Cl)c2Cl)C1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
		155566925	175864	0	None	56	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	293	1	1	2	3.5	Cn1cncc1-c1c[nH]c2ccc(Br)c(F)c12	10.1016/j.ejmech.2019.03.017
		CHEMBL4585956	175864	0	None	56	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	293	1	1	2	3.5	Cn1cncc1-c1c[nH]c2ccc(Br)c(F)c12	10.1016/j.ejmech.2019.03.017
		66801295	157141	0	None	-8	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	447	7	2	3	4.4	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(F)c1	10.1021/acs.jmedchem.7b00839
		CHEMBL4075144	157141	0	None	-8	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	447	7	2	3	4.4	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(F)c1	10.1021/acs.jmedchem.7b00839
		164621610	186191	0	None	2	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	355	4	0	4	3.3	O=C1c2ccc(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
		CHEMBL4872800	186191	0	None	2	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	355	4	0	4	3.3	O=C1c2ccc(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
		118706282	120530	0	None	-17	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
		CHEMBL3310111	120530	0	None	-17	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
		CHEMBL3545465	120530	0	None	-17	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
		66801246	112126	0	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	471	8	1	7	3.6	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cnc2ccccn12	10.1021/jm401895u
		CHEMBL3290019	112126	0	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	471	8	1	7	3.6	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cnc2ccccn12	10.1021/jm401895u
		118713681	114386	0	None	-3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	379	8	0	5	4.0	O=c1oc2ccccc2n1CCCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
		CHEMBL3331384	114386	0	None	-3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	379	8	0	5	4.0	O=c1oc2ccccc2n1CCCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
		44266203	98407	0	None	19	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	389	4	0	5	3.2	O=C1c2ccccc2CCCN1CCN1CCC(n2nnc3ccccc32)CC1	10.1016/s0960-894x(03)00077-5
		CHEMBL275475	98407	0	None	19	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	389	4	0	5	3.2	O=C1c2ccccc2CCCN1CCN1CCC(n2nnc3ccccc32)CC1	10.1016/s0960-894x(03)00077-5
		164621610	186191	0	None	2	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	355	4	0	4	3.3	O=C1c2ccc(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
		CHEMBL4872800	186191	0	None	2	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	355	4	0	4	3.3	O=C1c2ccc(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
		134157769	154059	0	None	10	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	531	14	2	6	4.7	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(OCCO)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		CHEMBL3984541	154059	0	None	10	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	531	14	2	6	4.7	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(OCCO)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		162676611	183474	0	None	8	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	501	9	1	6	5.1	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc4c(c3)NC(=O)C(C)O4)CC2)cc1	10.1016/j.ejmech.2020.112395
		CHEMBL4799274	183474	0	None	8	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	501	9	1	6	5.1	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc4c(c3)NC(=O)C(C)O4)CC2)cc1	10.1016/j.ejmech.2020.112395
		164614709	185209	0	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	383	6	0	4	4.1	O=C1c2ccc(Cl)cc2CC1CCCCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
		CHEMBL4857665	185209	0	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	383	6	0	4	4.1	O=C1c2ccc(Cl)cc2CC1CCCCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
		69729	169673	73	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	180	4	0	1	3.2	CCCCC(=O)c1ccc(F)cc1	10.1021/jm030030n
		CHEMBL443757	169673	73	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	180	4	0	1	3.2	CCCCC(=O)c1ccc(F)cc1	10.1021/jm030030n
		45272891	195915	0	None	72	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	459	9	3	5	2.4	COc1ccccc1N1CCN(C(=N)NCCCCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1016/j.bmcl.2009.06.038
		CHEMBL559260	195915	0	None	72	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	459	9	3	5	2.4	COc1ccccc1N1CCN(C(=N)NCCCCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1016/j.bmcl.2009.06.038
		44460642	205747	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	281	3	0	3	2.3	C#Cc1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
		CHEMBL82708	205747	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	281	3	0	3	2.3	C#Cc1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
		24873261	183194	0	None	-2	4	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	241	2	1	3	2.3	CCn1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
		CHEMBL4795756	183194	0	None	-2	4	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	241	2	1	3	2.3	CCn1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
		56944860	159007	0	None	-61	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	493	8	2	3	5.8	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc2ccccc12	10.1021/acs.jmedchem.7b00839
		CHEMBL4096479	159007	0	None	-61	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	493	8	2	3	5.8	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc2ccccc12	10.1021/acs.jmedchem.7b00839
		155520553	176509	0	None	1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	6.0	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4449590	176509	0	None	1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	6.0	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4596888	176509	0	None	1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	6.0	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmc.2019.06.028
		599482	202984	9	None	-10	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	202	1	2	2	1.8	COc1ccc2c3c([nH]c2c1)CNCC3	10.1016/j.bmcl.2003.09.027
		CHEMBL6310	202984	9	None	-10	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	202	1	2	2	1.8	COc1ccc2c3c([nH]c2c1)CNCC3	10.1016/j.bmcl.2003.09.027
		11282743	84634	0	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	430	8	1	4	4.4	N#Cc1ccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)cc1	10.1021/jm049702f
		CHEMBL222275	84634	0	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	430	8	1	4	4.4	N#Cc1ccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)cc1	10.1021/jm049702f
		42	2063	57	None	-251	18	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1016/j.bmcl.2021.128028
		56971	2063	57	None	-251	18	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1016/j.bmcl.2021.128028
		CHEMBL8412	2063	57	None	-251	18	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1016/j.bmcl.2021.128028
		135367403	164245	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
		CHEMBL4211303	164245	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
		127029650	138266	0	None	5	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	494	6	2	5	3.1	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
		CHEMBL3770581	138266	0	None	5	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	494	6	2	5	3.1	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
		162672312	183766	0	None	-4	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	10	1	4	5.1	COc1ccccc1N1CCN(CCCCCC(=O)Nc2cccc(C(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4795807	183766	0	None	-4	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	10	1	4	5.1	COc1ccccc1N1CCN(CCCCCC(=O)Nc2cccc(C(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4803872	183766	0	None	-4	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	10	1	4	5.1	COc1ccccc1N1CCN(CCCCCC(=O)Nc2cccc(C(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
		2921525	54870	14	None	-3	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	375	8	1	4	4.7	COc1ccc(CNCCC(c2ccccc2)c2ccc3c(c2)OCO3)cc1	10.1016/j.ejmech.2018.04.010
		CHEMBL1379600	54870	14	None	-3	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	375	8	1	4	4.7	COc1ccc(CNCCC(c2ccccc2)c2ccc3c(c2)OCO3)cc1	10.1016/j.ejmech.2018.04.010
		CHEMBL1613157	54870	14	None	-3	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	375	8	1	4	4.7	COc1ccc(CNCCC(c2ccccc2)c2ccc3c(c2)OCO3)cc1	10.1016/j.ejmech.2018.04.010
		10478367	71670	0	None	-281	7	Human	5.9	pKi	=	5.9	Binding	In vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	439	5	1	6	2.8	COc1ccc(NC(=O)N2CCN(c3ccccc3OC)CC2)cc1N1CCN(C)CC1	10.1016/j.bmcl.2005.07.024
		CHEMBL196370	71670	0	None	-281	7	Human	5.9	pKi	=	5.9	Binding	In vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	439	5	1	6	2.8	COc1ccc(NC(=O)N2CCN(c3ccccc3OC)CC2)cc1N1CCN(C)CC1	10.1016/j.bmcl.2005.07.024
		CHEMBL430500	71670	0	None	-281	7	Human	5.9	pKi	=	5.9	Binding	In vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	439	5	1	6	2.8	COc1ccc(NC(=O)N2CCN(c3ccccc3OC)CC2)cc1N1CCN(C)CC1	10.1016/j.bmcl.2005.07.024
		164623862	186005	0	None	-79	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	351	6	0	5	2.8	O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc21	10.1016/j.ejmech.2021.113243
		CHEMBL4870361	186005	0	None	-79	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	351	6	0	5	2.8	O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc21	10.1016/j.ejmech.2021.113243
		122483254	138096	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	5	0	3	5.6	CC1CC(C)CN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
		CHEMBL3764307	138096	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	5	0	3	5.6	CC1CC(C)CN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
		CHEMBL3765844	138096	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	5	0	3	5.6	CC1CC(C)CN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
		135367403	164245	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
		CHEMBL4211303	164245	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
		52952099	62583	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	365	5	1	5	3.9	Nc1ccc(N2CCN(CCC(=O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
		CHEMBL1782796	62583	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	365	5	1	5	3.9	Nc1ccc(N2CCN(CCC(=O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
		18137020	163929	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	360	7	1	4	2.5	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
		CHEMBL4207433	163929	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	360	7	1	4	2.5	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
		137637994	155942	0	None	2	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	482	6	0	5	4.0	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3cccc(F)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
		CHEMBL4061131	155942	0	None	2	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	482	6	0	5	4.0	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3cccc(F)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
		118626120	165789	0	None	-23	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	7	3.4	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4247770	165789	0	None	-23	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	7	3.4	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/j.ejmech.2018.01.002
		57400829	68431	0	None	3	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	387	6	1	4	3.4	O=S(=O)(NCCCN1CCC2CCCCC2C1)c1ccc2ncccc2c1	10.1016/j.bmc.2011.09.044
		CHEMBL1917352	68431	0	None	3	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	387	6	1	4	3.4	O=S(=O)(NCCCN1CCC2CCCCC2C1)c1ccc2ncccc2c1	10.1016/j.bmc.2011.09.044
		11256720	2055	79	None	-60255	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	353	3	1	5	2.5	O=S(=O)(c1cnc2c(c1)cccc2N1CCNCC1)c1ccccc1	10.1016/j.ejmech.2017.12.053
		9444	2055	79	None	-60255	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	353	3	1	5	2.5	O=S(=O)(c1cnc2c(c1)cccc2N1CCNCC1)c1ccccc1	10.1016/j.ejmech.2017.12.053
		CHEMBL1083390	2055	79	None	-60255	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	353	3	1	5	2.5	O=S(=O)(c1cnc2c(c1)cccc2N1CCNCC1)c1ccccc1	10.1016/j.ejmech.2017.12.053
		DB12680	2055	79	None	-60255	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	353	3	1	5	2.5	O=S(=O)(c1cnc2c(c1)cccc2N1CCNCC1)c1ccccc1	10.1016/j.ejmech.2017.12.053
		46233383	198901	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	285	5	0	2	4.6	Cc1cccc(C)c1-c1ccccc1SCCN(C)C	10.1016/j.bmc.2010.01.035
		CHEMBL584429	198901	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	285	5	0	2	4.6	Cc1cccc(C)c1-c1ccccc1SCCN(C)C	10.1016/j.bmc.2010.01.035
		13069624	120601	0	None	-2	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	382	5	0	8	0.6	Cn1c(=O)c2c(ncn2CCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		CHEMBL3360991	120601	0	None	-2	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	382	5	0	8	0.6	Cn1c(=O)c2c(ncn2CCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		CHEMBL3545931	120601	0	None	-2	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	382	5	0	8	0.6	Cn1c(=O)c2c(ncn2CCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		134130447	142307	0	None	-4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	402	9	0	5	4.5	c1ccc(-c2cc(OCCCCCN3CCN(c4ccccc4)CC3)ncn2)cc1	10.1016/j.bmc.2016.12.039
		CHEMBL3885319	142307	0	None	-4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	402	9	0	5	4.5	c1ccc(-c2cc(OCCCCCN3CCN(c4ccccc4)CC3)ncn2)cc1	10.1016/j.bmc.2016.12.039
		118728526	117721	0	None	-8	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	0	6	4.1	Cc1sc2ncn(CCCCCN3CCN(c4ccccc4)CC3)c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
		CHEMBL3401489	117721	0	None	-8	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	0	6	4.1	Cc1sc2ncn(CCCCCN3CCN(c4ccccc4)CC3)c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
		135367917	163595	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
		CHEMBL4203526	163595	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
		71458649	81430	0	None	-5	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	370	7	1	5	2.3	O=S(=O)(NC1CCN(CCOc2cccc(F)c2)C1)c1cccs1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159473	81430	0	None	-5	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	370	7	1	5	2.3	O=S(=O)(NC1CCN(CCOc2cccc(F)c2)C1)c1cccs1	10.1016/j.ejmech.2012.07.043
		134153539	154505	0	None	-3	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	390	5	0	3	6.0	Clc1ccc2sc(CCCCN3CCc4c(Cl)cccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
		CHEMBL3971383	154505	0	None	-3	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	390	5	0	3	6.0	Clc1ccc2sc(CCCCN3CCc4c(Cl)cccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
		CHEMBL3990611	154505	0	None	-3	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	390	5	0	3	6.0	Clc1ccc2sc(CCCCN3CCc4c(Cl)cccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
		72734865	106315	0	None	-39	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	268	1	3	3	2.0	NC(N)=NC(=O)c1ccc2c(c1)Nc1ccccc1O2	10.1016/j.bmc.2013.10.010
		CHEMBL3092756	106315	0	None	-39	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	268	1	3	3	2.0	NC(N)=NC(=O)c1ccc2c(c1)Nc1ccccc1O2	10.1016/j.bmc.2013.10.010
		CHEMBL3139103	106315	0	None	-39	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	268	1	3	3	2.0	NC(N)=NC(=O)c1ccc2c(c1)Nc1ccccc1O2	10.1016/j.bmc.2013.10.010
		134153539	154505	0	None	-3	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	390	5	0	3	6.0	Clc1ccc2sc(CCCCN3CCc4c(Cl)cccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
		CHEMBL3971383	154505	0	None	-3	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	390	5	0	3	6.0	Clc1ccc2sc(CCCCN3CCc4c(Cl)cccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
		CHEMBL3990611	154505	0	None	-3	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	390	5	0	3	6.0	Clc1ccc2sc(CCCCN3CCc4c(Cl)cccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
		155528967	171392	0	None	-31	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	510	7	1	5	5.4	O=c1c(-c2ccc(F)cc2)c2ccccn2c(=O)n1CCCCN1CCCC(c2c[nH]c3ccccc23)C1	10.1016/j.ejmech.2019.01.031
		CHEMBL4462139	171392	0	None	-31	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	510	7	1	5	5.4	O=c1c(-c2ccc(F)cc2)c2ccccn2c(=O)n1CCCCN1CCCC(c2c[nH]c3ccccc23)C1	10.1016/j.ejmech.2019.01.031
		155546350	173547	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	263	2	1	2	3.8	CCn1cncc1-c1c[nH]c2cc(F)c(Cl)cc12	10.1016/j.ejmech.2019.03.017
		CHEMBL4531898	173547	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	263	2	1	2	3.8	CCn1cncc1-c1c[nH]c2cc(F)c(Cl)cc12	10.1016/j.ejmech.2019.03.017
		135367917	163595	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
		CHEMBL4203526	163595	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
		168288545	191763	0	None	-31	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	372	8	3	9	1.1	COc1ccccc1N1CCN(CCCCNc2nc(N)nc(N)n2)CC1	10.1016/j.ejmech.2021.113931
		CHEMBL5197737	191763	0	None	-31	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	372	8	3	9	1.1	COc1ccccc1N1CCN(CCCCNc2nc(N)nc(N)n2)CC1	10.1016/j.ejmech.2021.113931
		44460918	205790	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	299	4	0	3	3.4	CC(C)c1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
		CHEMBL83090	205790	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	299	4	0	3	3.4	CC(C)c1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
		49756	204312	13	None	-5	8	Human	6.8	pKi	=	6.8	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	232	4	1	2	2.6	COc1ccc2[nH]c(C)c(CCN(C)C)c2c1	10.1021/jm990550b
		CHEMBL7143	204312	13	None	-5	8	Human	6.8	pKi	=	6.8	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	232	4	1	2	2.6	COc1ccc2[nH]c(C)c(CCN(C)C)c2c1	10.1021/jm990550b
		136180316	117710	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	362	6	1	4	3.1	O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
		CHEMBL3401478	117710	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	362	6	1	4	3.1	O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
		57399866	71541	0	None	3	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	484	5	0	5	4.1	O=S(=O)(c1cnc2ccccc2c1)N1CCC(CN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
		CHEMBL1949974	71541	0	None	3	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	484	5	0	5	4.1	O=S(=O)(c1cnc2ccccc2c1)N1CCC(CN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
		CHEMBL1962960	71541	0	None	3	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	484	5	0	5	4.1	O=S(=O)(c1cnc2ccccc2c1)N1CCC(CN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
		156018141	177921	0	None	-36	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	439	9	0	5	3.4	COc1ccccc1N1CCN(CCCCCCN2C(=O)[C@H]3[C@@H]4CC[C@@H](C4)[C@H]3C2=O)CC1	10.1016/j.bmc.2020.115459
		CHEMBL4645292	177921	0	None	-36	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	439	9	0	5	3.4	COc1ccccc1N1CCN(CCCCCCN2C(=O)[C@H]3[C@@H]4CC[C@@H](C4)[C@H]3C2=O)CC1	10.1016/j.bmc.2020.115459
		44352308	117487	0	None	-177	12	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandBinding affinity towards human 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	339	5	2	2	4.0	Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C	10.1021/jm0155190
		CHEMBL339980	117487	0	None	-177	12	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandBinding affinity towards human 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	339	5	2	2	4.0	Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C	10.1021/jm0155190
		118728514	117709	0	None	-27	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	444	7	1	5	4.8	Cc1sc2nc(CCCCCN3CCN(c4ccc(Cl)cc4)CC3)[nH]c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
		CHEMBL3401477	117709	0	None	-27	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	444	7	1	5	4.8	Cc1sc2nc(CCCCCN3CCN(c4ccc(Cl)cc4)CC3)[nH]c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
		118728511	117706	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	8	1	5	3.8	Cc1cc2c(=O)[nH]c(CCCCCN3CCN(Cc4ccccc4)CC3)nc2s1	10.1016/j.bmcl.2015.02.042
		CHEMBL3401474	117706	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	8	1	5	3.8	Cc1cc2c(=O)[nH]c(CCCCCN3CCN(Cc4ccccc4)CC3)nc2s1	10.1016/j.bmcl.2015.02.042
		162671033	183755	0	None	-4	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2cccnc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
		CHEMBL4793296	183755	0	None	-4	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2cccnc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
		CHEMBL4803797	183755	0	None	-4	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2cccnc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
		11112531	102177	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	417	6	1	3	4.8	Cc1cccc(C)c1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL302723	102177	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	417	6	1	3	4.8	Cc1cccc(C)c1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1016/j.bmc.2019.06.028
		11112531	102177	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	417	6	1	3	4.8	Cc1cccc(C)c1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
		CHEMBL302723	102177	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	417	6	1	3	4.8	Cc1cccc(C)c1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
		142601318	185545	0	None	6	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4863036	185545	0	None	6	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		2853434	117931	15	None	2	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	386	3	1	2	4.9	O=S(=O)(c1ccccc1)N1C=Cc2ccccc2C1c1c[nH]c2ccccc12	10.1016/j.bmcl.2015.03.049
		CHEMBL3403335	117931	15	None	2	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	386	3	1	2	4.9	O=S(=O)(c1ccccc1)N1C=Cc2ccccc2C1c1c[nH]c2ccccc12	10.1016/j.bmcl.2015.03.049
		134145143	150734	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	271	4	1	4	2.8	CNCc1cc2c(c(-c3ccccc3OC)c1)OCO2	10.1016/j.ejmech.2016.07.029
		CHEMBL3956286	150734	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	271	4	1	4	2.8	CNCc1cc2c(c(-c3ccccc3OC)c1)OCO2	10.1016/j.ejmech.2016.07.029
		11132982	51908	0	None	9	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	393	8	1	6	4.1	O=C(CCCCCN1CCN(c2nc3ccccc3o2)CC1)c1ccccc1O	10.1021/jm020994z
		CHEMBL158592	51908	0	None	9	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	393	8	1	6	4.1	O=C(CCCCCN1CCN(c2nc3ccccc3o2)CC1)c1ccccc1O	10.1021/jm020994z
		90654674	110095	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	500	6	1	5	3.8	CSc1ccccc1N1CCN(Cc2ccc(C(=O)N3Cc4ccccc4C[C@H]3C(N)=O)cc2)CC1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235746	110095	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	500	6	1	5	3.8	CSc1ccccc1N1CCN(Cc2ccc(C(=O)N3Cc4ccccc4C[C@H]3C(N)=O)cc2)CC1	10.1016/j.ejmech.2014.03.005
		164619075	186183	0	None	-9	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	413	7	0	5	2.8	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2021.128028
		CHEMBL4872713	186183	0	None	-9	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	413	7	0	5	2.8	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2021.128028
		142601318	185545	0	None	6	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4863036	185545	0	None	6	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		25107581	192631	0	None	-14	3	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	505	12	1	7	3.7	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	10.1021/jm800615e
		CHEMBL521687	192631	0	None	-14	3	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	505	12	1	7	3.7	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	10.1021/jm800615e
		10378785	16770	0	None	-5	4	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	277	0	0	3	3.0	CN1CCc2ccc3oc(=O)c4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
		CHEMBL124419	16770	0	None	-5	4	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	277	0	0	3	3.0	CN1CCc2ccc3oc(=O)c4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
		46206345	124608	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	4	1	3	3.5	COc1ccc(-c2ccccc2)cc1OC1CCNCC1	nan
		CHEMBL3640613	124608	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	4	1	3	3.5	COc1ccc(-c2ccccc2)cc1OC1CCNCC1	nan
		46206345	124608	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	4	1	3	3.5	COc1ccc(-c2ccccc2)cc1OC1CCNCC1	nan
		CHEMBL3640613	124608	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	4	1	3	3.5	COc1ccc(-c2ccccc2)cc1OC1CCNCC1	nan
		46233449	201992	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	287	6	0	5	2.3	COc1cccc(OC)c1-c1ccnc(CCN(C)C)n1	10.1016/j.bmc.2010.01.035
		CHEMBL608138	201992	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	287	6	0	5	2.3	COc1cccc(OC)c1-c1ccnc(CCN(C)C)n1	10.1016/j.bmc.2010.01.035
		164618510	185933	0	None	-8	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	481	7	0	5	4.1	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2021.128028
		CHEMBL4869198	185933	0	None	-8	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	481	7	0	5	4.1	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2021.128028
		49862237	15007	0	None	6	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	395	6	0	5	4.3	COc1ccc(OC)c(C2CCN(Cc3cnn(-c4ccccc4F)c3C)C2)c1	10.1016/j.bmcl.2010.06.033
		CHEMBL1209157	15007	0	None	6	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	395	6	0	5	4.3	COc1ccc(OC)c(C2CCN(Cc3cnn(-c4ccccc4F)c3C)C2)c1	10.1016/j.bmcl.2010.06.033
		11783562	54402	0	None	-4	2	Rat	7.8	pKi	=	7.8	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	368	8	1	5	3.6	COc1ccccc1N1CCN(CCCCC(=O)c2cccc(O)c2)CC1	10.1021/jm020994z
		CHEMBL160906	54402	0	None	-4	2	Rat	7.8	pKi	=	7.8	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	368	8	1	5	3.6	COc1ccccc1N1CCN(CCCCC(=O)c2cccc(O)c2)CC1	10.1021/jm020994z
		5074	3332	80	None	-36	30	Rat	7.8	pKi	=	7.8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030030n
		97	3332	80	None	-36	30	Rat	7.8	pKi	=	7.8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030030n
		CHEMBL267777	3332	80	None	-36	30	Rat	7.8	pKi	=	7.8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030030n
		DB12693	3332	80	None	-36	30	Rat	7.8	pKi	=	7.8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030030n
		72711488	102585	0	None	2	2	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	382	9	1	5	2.4	O=C1C2CCCN2C(=O)N1CCCCNCCOc1cccc2cccnc12	10.1021/jm400766k
		CHEMBL2431041	102585	0	None	2	2	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	382	9	1	5	2.4	O=C1C2CCCN2C(=O)N1CCCCNCCOc1cccc2cccnc12	10.1021/jm400766k
		CHEMBL3040835	102585	0	None	2	2	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	382	9	1	5	2.4	O=C1C2CCCN2C(=O)N1CCCCNCCOc1cccc2cccnc12	10.1021/jm400766k
		76332577	106278	0	None	7	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	409	5	0	3	6.1	CC(C)c1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
		CHEMBL3121419	106278	0	None	7	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	409	5	0	3	6.1	CC(C)c1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
		CHEMBL3139022	106278	0	None	7	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	409	5	0	3	6.1	CC(C)c1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
		71451458	81443	0	None	-3	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	426	8	1	5	3.5	CSc1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(Cl)c2)C1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159486	81443	0	None	-3	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	426	8	1	5	3.5	CSc1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(Cl)c2)C1	10.1016/j.ejmech.2012.07.043
		118731358	118194	0	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	530	10	0	4	5.4	O=C([C@@H]1CCCN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
		CHEMBL3409041	118194	0	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	530	10	0	4	5.4	O=C([C@@H]1CCCN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
		25107716	2351	43	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm3003679
		8436	2351	43	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm3003679
		CHEMBL522691	2351	43	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm3003679
		11393128	182861	0	None	-7	4	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	323	2	1	3	3.8	CC(C)n1nc2c(c1-c1ccc(C(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
		CHEMBL4791646	182861	0	None	-7	4	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	323	2	1	3	3.8	CC(C)n1nc2c(c1-c1ccc(C(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
		25107716	2351	43	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor after 1.5 hrs by cell based assayDisplacement of [3H]-LSD from human 5-HT7 receptor after 1.5 hrs by cell based assay	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.ejmech.2016.05.005
		8436	2351	43	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor after 1.5 hrs by cell based assayDisplacement of [3H]-LSD from human 5-HT7 receptor after 1.5 hrs by cell based assay	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.ejmech.2016.05.005
		CHEMBL522691	2351	43	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor after 1.5 hrs by cell based assayDisplacement of [3H]-LSD from human 5-HT7 receptor after 1.5 hrs by cell based assay	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.ejmech.2016.05.005
		66801344	159422	0	None	-4	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	479	7	2	3	5.4	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
		CHEMBL4100951	159422	0	None	-4	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	479	7	2	3	5.4	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
		122178699	121366	0	None	3	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	397	7	0	5	4.6	CCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1016/j.bmc.2020.115578
		CHEMBL3581245	121366	0	None	3	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	397	7	0	5	4.6	CCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1016/j.bmc.2020.115578
		164614709	185209	0	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	383	6	0	4	4.1	O=C1c2ccc(Cl)cc2CC1CCCCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
		CHEMBL4857665	185209	0	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	383	6	0	4	4.1	O=C1c2ccc(Cl)cc2CC1CCCCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
		164622973	186123	0	None	-6	6	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	397	6	0	4	4.5	CC1(CCCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O	10.1016/j.ejmech.2021.113243
		CHEMBL4871868	186123	0	None	-6	6	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	397	6	0	4	4.5	CC1(CCCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O	10.1016/j.ejmech.2021.113243
		25107716	2351	43	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.bmc.2014.01.016
		8436	2351	43	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.bmc.2014.01.016
		CHEMBL522691	2351	43	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.bmc.2014.01.016
		44408630	139308	0	None	100	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	376	7	0	5	3.9	CC(C)(CCCN1CCCC(c2cnco2)C1)S(=O)(=O)c1ccccc1	10.1016/j.bmcl.2005.11.067
		CHEMBL379238	139308	0	None	100	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	376	7	0	5	3.9	CC(C)(CCCN1CCCC(c2cnco2)C1)S(=O)(=O)c1ccccc1	10.1016/j.bmcl.2005.11.067
		71678857	147271	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in CHO-K1 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in CHO-K1 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	388	6	0	4	4.7	COc1ccccc1-c1cccc(CN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.ejmech.2016.07.029
		CHEMBL3928716	147271	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in CHO-K1 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in CHO-K1 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	388	6	0	4	4.7	COc1ccccc1-c1cccc(CN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.ejmech.2016.07.029
		92042877	149175	1	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	241	4	1	2	3.4	CNCc1ccc(C)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
		CHEMBL3943658	149175	1	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	241	4	1	2	3.4	CNCc1ccc(C)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
		25107716	2351	43	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5HT7 receptor after 1.5 hrsDisplacement of [3H]LSD from human 5HT7 receptor after 1.5 hrs	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.bmcl.2013.09.025
		8436	2351	43	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5HT7 receptor after 1.5 hrsDisplacement of [3H]LSD from human 5HT7 receptor after 1.5 hrs	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.bmcl.2013.09.025
		CHEMBL522691	2351	43	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5HT7 receptor after 1.5 hrsDisplacement of [3H]LSD from human 5HT7 receptor after 1.5 hrs	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.bmcl.2013.09.025
		56944287	112104	0	None	-4	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	515	9	1	6	4.8	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
		CHEMBL3289998	112104	0	None	-4	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	515	9	1	6	4.8	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
		122178699	121366	0	None	3	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	397	7	0	5	4.6	CCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
		CHEMBL3581245	121366	0	None	3	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	397	7	0	5	4.6	CCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
		145946966	167597	0	None	-7	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	354	7	0	4	3.9	COc1ccccc1N1CCN(CCCOc2ccc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
		CHEMBL4209888	167597	0	None	-7	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	354	7	0	4	3.9	COc1ccccc1N1CCN(CCCOc2ccc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
		CHEMBL4300899	167597	0	None	-7	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	354	7	0	4	3.9	COc1ccccc1N1CCN(CCCOc2ccc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
		164622973	186123	0	None	-6	6	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	397	6	0	4	4.5	CC1(CCCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O	10.1016/j.ejmech.2021.113243
		CHEMBL4871868	186123	0	None	-6	6	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	397	6	0	4	4.5	CC1(CCCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O	10.1016/j.ejmech.2021.113243
		162670302	182733	0	None	19	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	419	8	1	6	3.8	COc1ccc(-c2ccccc2C2CCN(C[C@@H](O)COc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
		CHEMBL4789865	182733	0	None	19	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	419	8	1	6	3.8	COc1ccc(-c2ccccc2C2CCN(C[C@@H](O)COc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
		71062035	93116	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccccn3)CC2)cc1	10.1016/j.bmc.2014.01.016
		CHEMBL2442994	93116	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccccn3)CC2)cc1	10.1016/j.bmc.2014.01.016
		71062035	93116	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccccn3)CC2)cc1	10.1016/j.bmcl.2013.09.025
		CHEMBL2442994	93116	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccccn3)CC2)cc1	10.1016/j.bmcl.2013.09.025
		11785183	84713	0	None	1	4	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins	ChEMBL	419	8	1	3	4.9	Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/acs.jmedchem.5b00982
		CHEMBL222755	84713	0	None	1	4	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins	ChEMBL	419	8	1	3	4.9	Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/acs.jmedchem.5b00982
		11785183	84713	0	None	1	4	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	419	8	1	3	4.9	Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
		CHEMBL222755	84713	0	None	1	4	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	419	8	1	3	4.9	Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
		135458392	97426	5	None	-1	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	209	0	2	3	2.2	CNC1=Nc2cccc(Cl)c2C(C)N1	10.1016/j.bmcl.2007.10.080
		CHEMBL269964	97426	5	None	-1	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	209	0	2	3	2.2	CNC1=Nc2cccc(Cl)c2C(C)N1	10.1016/j.bmcl.2007.10.080
		46204728	124568	0	None	-	1	Rat	7.8	pKi	=	7.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	273	3	1	2	3.7	Cc1ccccc1-c1ccc(Cl)c(OC2CNC2)c1	nan
		CHEMBL3640575	124568	0	None	-	1	Rat	7.8	pKi	=	7.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	273	3	1	2	3.7	Cc1ccccc1-c1ccc(Cl)c(OC2CNC2)c1	nan
		46204728	124568	0	None	-	1	Rat	7.8	pKi	=	7.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	273	3	1	2	3.7	Cc1ccccc1-c1ccc(Cl)c(OC2CNC2)c1	nan
		CHEMBL3640575	124568	0	None	-	1	Rat	7.8	pKi	=	7.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	273	3	1	2	3.7	Cc1ccccc1-c1ccc(Cl)c(OC2CNC2)c1	nan
		CHEMBL5084167	214899	0	None	-63	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.1c00497
		134137560	142705	0	None	6	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	485	11	1	4	5.9	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@@H](C)c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		CHEMBL3892201	142705	0	None	6	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	485	11	1	4	5.9	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@@H](C)c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		162673308	183109	0	None	25	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	443	8	1	6	3.8	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccccc3C#N)CC2)cc1	10.1016/j.ejmech.2020.112395
		CHEMBL4794688	183109	0	None	25	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	443	8	1	6	3.8	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccccc3C#N)CC2)cc1	10.1016/j.ejmech.2020.112395
		18377409	206047	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	350	5	1	3	4.0	O=C1Nc2cccc3c2C1(CCCCN1CCc2occc2C1)CCC3	10.1016/s0960-894x(02)00485-7
		CHEMBL85249	206047	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	350	5	1	3	4.0	O=C1Nc2cccc3c2C1(CCCCN1CCc2occc2C1)CCC3	10.1016/s0960-894x(02)00485-7
		16006492	97469	7	None	-3	6	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	195	0	2	3	2.0	CC1NC(N)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.078
		CHEMBL270177	97469	7	None	-3	6	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	195	0	2	3	2.0	CC1NC(N)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.078
		10597140	63045	0	None	25	6	Human	7.8	pKi	=	7.8	Binding	Binding affinity toward 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]-5-CT as radioligand.Binding affinity toward 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]-5-CT as radioligand.	ChEMBL	400	5	0	3	4.5	CC1CCN(CC[C@H]2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
		CHEMBL1788231	63045	0	None	25	6	Human	7.8	pKi	=	7.8	Binding	Binding affinity toward 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]-5-CT as radioligand.Binding affinity toward 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]-5-CT as radioligand.	ChEMBL	400	5	0	3	4.5	CC1CCN(CC[C@H]2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
		5074	3332	80	None	-36	30	Rat	7.8	pKi	=	7.8	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1016/s0960-894x(00)00166-9
		97	3332	80	None	-36	30	Rat	7.8	pKi	=	7.8	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1016/s0960-894x(00)00166-9
		CHEMBL267777	3332	80	None	-36	30	Rat	7.8	pKi	=	7.8	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1016/s0960-894x(00)00166-9
		DB12693	3332	80	None	-36	30	Rat	7.8	pKi	=	7.8	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1016/s0960-894x(00)00166-9
		10767321	98269	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	486	6	0	4	4.4	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2cc(Br)c(Br)s2)CC1	10.1021/jm970519e
		CHEMBL274595	98269	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	486	6	0	4	4.4	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2cc(Br)c(Br)s2)CC1	10.1021/jm970519e
		10767321	98269	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	486	6	0	4	4.4	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2cc(Br)c(Br)s2)CC1	10.1016/s0960-894x(00)00166-9
		CHEMBL274595	98269	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	486	6	0	4	4.4	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2cc(Br)c(Br)s2)CC1	10.1016/s0960-894x(00)00166-9
		10715998	45228	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	400	5	0	3	4.5	CC1CCN(CC[C@@H]2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm030841r
		CHEMBL152595	45228	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	400	5	0	3	4.5	CC1CCN(CC[C@@H]2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm030841r
		44368754	46901	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	561	7	0	4	6.9	CC1CCN(CC[C@@H](C)C(C)S(=O)(=O)c2cc(Br)c(Br)cc2-c2cccs2)CC1	10.1021/jm030841r
		CHEMBL154090	46901	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	561	7	0	4	6.9	CC1CCN(CC[C@@H](C)C(C)S(=O)(=O)c2cc(Br)c(Br)cc2-c2cccs2)CC1	10.1021/jm030841r
		142601328	185003	0	None	39	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4854605	185003	0	None	39	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		162664339	182128	0	None	-14	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	441	7	1	6	4.0	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1csc2ccccc12	10.1016/j.ejmech.2020.112149
		CHEMBL4782149	182128	0	None	-14	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	441	7	1	6	4.0	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1csc2ccccc12	10.1016/j.ejmech.2020.112149
		24865727	193113	0	None	-10	11	Human	7.8	pKi	=	7.8	Binding	Displacement of radioligand from human cloned 5HT7 receptorDisplacement of radioligand from human cloned 5HT7 receptor	ChEMBL	479	7	0	5	4.4	Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCS5(=O)=O)c4)CC3)cccc2n1	10.1021/jm8001444
		CHEMBL522708	193113	0	None	-10	11	Human	7.8	pKi	=	7.8	Binding	Displacement of radioligand from human cloned 5HT7 receptorDisplacement of radioligand from human cloned 5HT7 receptor	ChEMBL	479	7	0	5	4.4	Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCS5(=O)=O)c4)CC3)cccc2n1	10.1021/jm8001444
		5074	3332	80	None	-69	30	Human	7.8	pKi	=	7.8	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030841r
		97	3332	80	None	-69	30	Human	7.8	pKi	=	7.8	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030841r
		CHEMBL267777	3332	80	None	-69	30	Human	7.8	pKi	=	7.8	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030841r
		DB12693	3332	80	None	-69	30	Human	7.8	pKi	=	7.8	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030841r
		76284721	105008	0	None	27	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	480	10	1	5	3.9	O=C(CCOCCN1CCN(c2ccccc2-c2ccc(F)cc2)CC1)NCc1ccc(F)nc1	10.1016/j.bmc.2014.01.016
		CHEMBL3113597	105008	0	None	27	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	480	10	1	5	3.9	O=C(CCOCCN1CCN(c2ccccc2-c2ccc(F)cc2)CC1)NCc1ccc(F)nc1	10.1016/j.bmc.2014.01.016
		72550645	114089	0	None	-2	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	505	11	1	4	6.0	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1	10.1016/j.bmc.2014.07.026
		CHEMBL3326993	114089	0	None	-2	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	505	11	1	4	6.0	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1	10.1016/j.bmc.2014.07.026
		16006492	97469	7	None	-3	6	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	195	0	2	3	2.0	CC1NC(N)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.080
		CHEMBL270177	97469	7	None	-3	6	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	195	0	2	3	2.0	CC1NC(N)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.080
		46205696	124591	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	267	3	0	2	3.8	COc1ccc(-c2ccccc2)cc1C1CCN(C)C1	nan
		CHEMBL3640597	124591	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	267	3	0	2	3.8	COc1ccc(-c2ccccc2)cc1C1CCN(C)C1	nan
		71459269	82960	0	None	-660	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	555	7	0	4	6.3	Fc1cccc2c1nc(OCC1CCN(CCCc3ccc(I)cc3)CC1)c1cccnc12	10.1021/jm300943r
		CHEMBL2181166	82960	0	None	-660	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	555	7	0	4	6.3	Fc1cccc2c1nc(OCC1CCN(CCCc3ccc(I)cc3)CC1)c1cccnc12	10.1021/jm300943r
		45273816	195781	0	None	79	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	428	8	3	3	3.5	Cc1cccc(S(=O)(=O)NCCCCNC(=N)N2CCC(c3ccccc3)CC2)c1	10.1016/j.bmcl.2009.06.038
		CHEMBL557740	195781	0	None	79	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	428	8	3	3	3.5	Cc1cccc(S(=O)(=O)NCCCCNC(=N)N2CCC(c3ccccc3)CC2)c1	10.1016/j.bmcl.2009.06.038
		1220	187	55	None	-75	44	Rat	6.8	pKi	=	6.8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm030030n
		31	187	55	None	-75	44	Rat	6.8	pKi	=	6.8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm030030n
		7	187	55	None	-75	44	Rat	6.8	pKi	=	6.8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm030030n
		CHEMBL56	187	55	None	-75	44	Rat	6.8	pKi	=	6.8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm030030n
		46205696	124591	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	267	3	0	2	3.8	COc1ccc(-c2ccccc2)cc1C1CCN(C)C1	nan
		CHEMBL3640597	124591	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	267	3	0	2	3.8	COc1ccc(-c2ccccc2)cc1C1CCN(C)C1	nan
		24873257	180256	0	None	-10	4	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	289	2	1	3	3.2	c1ccc(-c2c3c(nn2-c2ccccc2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
		CHEMBL4750414	180256	0	None	-10	4	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	289	2	1	3	3.2	c1ccc(-c2c3c(nn2-c2ccccc2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
		11312173	182111	0	None	-151	4	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	285	2	1	3	3.1	Fc1ccc(-c2c3c(nn2C2CCC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
		CHEMBL4782005	182111	0	None	-151	4	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	285	2	1	3	3.1	Fc1ccc(-c2c3c(nn2C2CCC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
		66801430	157714	0	None	-2	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	457	7	2	3	4.9	Cc1cccc(S(=O)(=O)NCCCN2CC=C(c3c(C)[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
		CHEMBL4081987	157714	0	None	-2	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	457	7	2	3	4.9	Cc1cccc(S(=O)(=O)NCCCN2CC=C(c3c(C)[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
		66801625	158285	0	None	-1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	493	7	2	3	5.7	Cc1[nH]c2ccc(Cl)cc2c1C1=CCN(CCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1021/acs.jmedchem.7b00839
		CHEMBL4088925	158285	0	None	-1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	493	7	2	3	5.7	Cc1[nH]c2ccc(Cl)cc2c1C1=CCN(CCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1021/acs.jmedchem.7b00839
		156021073	178166	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	335	2	1	4	4.4	CCCN1CCc2cccc3c2C1Cc1ccc2nc(N)sc2c1-3	10.1016/j.bmc.2020.115578
		CHEMBL4649078	178166	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	335	2	1	4	4.4	CCCN1CCc2cccc3c2C1Cc1ccc2nc(N)sc2c1-3	10.1016/j.bmc.2020.115578
		90644077	112087	0	None	-10	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	456	7	1	7	3.5	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
		CHEMBL3289981	112087	0	None	-10	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	456	7	1	7	3.5	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
		168279281	191022	0	None	-26	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	342	7	3	8	1.1	Nc1nc(N)nc(NCCCCN2CCN(c3ccccc3)CC2)n1	10.1016/j.ejmech.2021.113931
		CHEMBL5186821	191022	0	None	-26	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	342	7	3	8	1.1	Nc1nc(N)nc(NCCCCN2CCN(c3ccccc3)CC2)n1	10.1016/j.ejmech.2021.113931
		71456677	81161	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	408	7	1	3	4.8	Cc1ccccc1C(=O)NCC1CCN(CCOc2ccccc2C(C)(C)C)CC1	10.1016/j.ejmech.2012.07.043
		CHEMBL2158027	81161	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	408	7	1	3	4.8	Cc1ccccc1C(=O)NCC1CCN(CCOc2ccccc2C(C)(C)C)CC1	10.1016/j.ejmech.2012.07.043
		155568794	176098	0	None	-53	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	336	7	3	4	3.5	COc1ccc2[nH]cc(CCNCc3ccc(-c4cn[nH]c4)o3)c2c1	10.1016/j.ejmech.2019.111857
		CHEMBL4591410	176098	0	None	-53	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	336	7	3	4	3.5	COc1ccc2[nH]cc(CCNCc3ccc(-c4cn[nH]c4)o3)c2c1	10.1016/j.ejmech.2019.111857
		122181344	121886	0	None	-4	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	460	7	1	4	4.2	O=C1NC2(CCCCC2c2ccccc2)C(=O)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2015.04.026
		CHEMBL3590096	121886	0	None	-4	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	460	7	1	4	4.2	O=C1NC2(CCCCC2c2ccccc2)C(=O)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2015.04.026
		164608896	184420	0	None	-223	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	382	4	1	7	2.7	CC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
		CHEMBL4846146	184420	0	None	-223	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	382	4	1	7	2.7	CC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
		162666977	183735	0	None	-7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	9	1	4	4.8	COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4787400	183735	0	None	-7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	9	1	4	4.8	COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4803559	183735	0	None	-7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	9	1	4	4.8	COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
		122483246	138098	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	410	6	0	3	6.5	O=C(CCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3763582	138098	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	410	6	0	3	6.5	O=C(CCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765846	138098	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	410	6	0	3	6.5	O=C(CCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		127049059	140813	0	None	-154	7	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	404	6	1	5	3.6	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3o1)CC2	10.1016/j.bmc.2016.06.011
		CHEMBL3818935	140813	0	None	-154	7	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	404	6	1	5	3.6	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3o1)CC2	10.1016/j.bmc.2016.06.011
		52952202	62586	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	389	5	0	5	4.6	N#Cc1ccc(N2CCCN(CCC(=O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
		CHEMBL1782800	62586	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	389	5	0	5	4.6	N#Cc1ccc(N2CCCN(CCC(=O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
		155558408	174755	0	None	-16	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	348	4	1	7	1.7	Cc1cc(Cl)ccc1OCc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
		CHEMBL4560883	174755	0	None	-16	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	348	4	1	7	1.7	Cc1cc(Cl)ccc1OCc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
		71462776	82963	0	None	-125	6	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	460	5	0	3	5.5	CCCN1CCC(COc2nc3c(I)cccc3c3ccccc23)CC1	10.1021/jm300943r
		CHEMBL2181169	82963	0	None	-125	6	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	460	5	0	3	5.5	CCCN1CCC(COc2nc3c(I)cccc3c3ccccc23)CC1	10.1021/jm300943r
		90654690	110076	0	None	-10	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	418	9	1	5	2.6	CSc1ccccc1N1CCN(CCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235727	110076	0	None	-10	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	418	9	1	5	2.6	CSc1ccccc1N1CCN(CCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
		53361626	66427	0	None	-8	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	6	0	6	4.2	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.ejmech.2011.04.060
		CHEMBL1851948	66427	0	None	-8	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	6	0	6	4.2	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.ejmech.2011.04.060
		CHEMBL3216277	66427	0	None	-8	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	6	0	6	4.2	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.ejmech.2011.04.060
		122483246	138098	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	410	6	0	3	6.5	O=C(CCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3763582	138098	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	410	6	0	3	6.5	O=C(CCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765846	138098	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	410	6	0	3	6.5	O=C(CCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		162662435	183716	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	453	9	2	5	5.0	COc1ccccc1N1CCN(CCCCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4780228	183716	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	453	9	2	5	5.0	COc1ccccc1N1CCN(CCCCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4803308	183716	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	453	9	2	5	5.0	COc1ccccc1N1CCN(CCCCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1	10.1016/j.ejmech.2020.112437
		11260739	85138	0	None	2	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	8	1	5	3.8	COc1ccccc1N1CCN(CCCC(=O)NC2CCCc3cccc(OC)c32)CC1	10.1021/jm049702f
		CHEMBL224929	85138	0	None	2	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	8	1	5	3.8	COc1ccccc1N1CCN(CCCC(=O)NC2CCCc3cccc(OC)c32)CC1	10.1021/jm049702f
		127036186	137414	0	None	-4	19	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay	ChEMBL	254	7	1	1	3.7	C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12	10.1016/j.bmcl.2015.12.053
		CHEMBL3753318	137414	0	None	-4	19	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay	ChEMBL	254	7	1	1	3.7	C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12	10.1016/j.bmcl.2015.12.053
		44324535	13112	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	293	3	2	4	3.2	CC(=O)c1cccc(-c2cccc(NC3=NCCN3)c2C)c1	10.1016/s0960-894x(02)00925-3
		CHEMBL1190414	13112	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	293	3	2	4	3.2	CC(=O)c1cccc(-c2cccc(NC3=NCCN3)c2C)c1	10.1016/s0960-894x(02)00925-3
		CHEMBL540821	13112	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	293	3	2	4	3.2	CC(=O)c1cccc(-c2cccc(NC3=NCCN3)c2C)c1	10.1016/s0960-894x(02)00925-3
		155547197	173595	0	None	-758	7	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	341	6	0	4	3.4	O=C(CCCN1CCCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
		CHEMBL4533305	173595	0	None	-758	7	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	341	6	0	4	3.4	O=C(CCCN1CCCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
		6918515	2612	38	None	-4	7	Human	6.8	pKi	=	6.8	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	294	5	1	2	3.9	COc1ccc2c(c1)c(CCN(C)C)c([nH]2)c1ccccc1	10.1021/jm990550b
		71	2612	38	None	-4	7	Human	6.8	pKi	=	6.8	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	294	5	1	2	3.9	COc1ccc2c(c1)c(CCN(C)C)c([nH]2)c1ccccc1	10.1021/jm990550b
		CHEMBL7318	2612	38	None	-4	7	Human	6.8	pKi	=	6.8	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	294	5	1	2	3.9	COc1ccc2c(c1)c(CCN(C)C)c([nH]2)c1ccccc1	10.1021/jm990550b
		55479093	81421	1	None	-1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	366	7	1	5	2.6	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1cccs1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159464	81421	1	None	-1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	366	7	1	5	2.6	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1cccs1	10.1016/j.ejmech.2012.07.043
		46206018	124598	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	265	2	0	1	4.4	Cc1ccc(-c2ccccc2C2CCN(C)C2)cc1C	nan
		CHEMBL3640604	124598	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	265	2	0	1	4.4	Cc1ccc(-c2ccccc2C2CCN(C)C2)cc1C	nan
		46206018	124598	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	265	2	0	1	4.4	Cc1ccc(-c2ccccc2C2CCN(C)C2)cc1C	nan
		CHEMBL3640604	124598	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	265	2	0	1	4.4	Cc1ccc(-c2ccccc2C2CCN(C)C2)cc1C	nan
		11739679	169852	0	None	-776	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity against human cloned 5-hydroxytryptamine 7 receptor stably expressed in CHO cells using [3H]LSDBinding affinity against human cloned 5-hydroxytryptamine 7 receptor stably expressed in CHO cells using [3H]LSD	ChEMBL	353	3	2	5	2.8	Nc1ccc(S(=O)(=O)n2cc(C3=CCNCC3)c3ccccc32)cc1	10.1016/j.bmcl.2004.10.064
		CHEMBL444015	169852	0	None	-776	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity against human cloned 5-hydroxytryptamine 7 receptor stably expressed in CHO cells using [3H]LSDBinding affinity against human cloned 5-hydroxytryptamine 7 receptor stably expressed in CHO cells using [3H]LSD	ChEMBL	353	3	2	5	2.8	Nc1ccc(S(=O)(=O)n2cc(C3=CCNCC3)c3ccccc32)cc1	10.1016/j.bmcl.2004.10.064
		168298474	192719	0	None	-3	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant	ChEMBL	384	8	0	5	3.9	CCOCC(Oc1c(C)cccc1C)N1CCN(c2ccccc2OC)CC1	10.1016/j.bmcl.2021.128275
		CHEMBL5219968	192719	0	None	-3	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant	ChEMBL	384	8	0	5	3.9	CCOCC(Oc1c(C)cccc1C)N1CCN(c2ccccc2OC)CC1	10.1016/j.bmcl.2021.128275
		57399090	68421	0	None	-8	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	440	8	1	6	2.7	COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc3ncccc3c2)CC1	10.1016/j.bmc.2011.09.044
		CHEMBL1917342	68421	0	None	-8	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	440	8	1	6	2.7	COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc3ncccc3c2)CC1	10.1016/j.bmc.2011.09.044
		168284197	190856	0	None	-12	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	515	12	4	9	3.6	COc1ccccc1N1CCN(CCCCNc2nc(N)nc(NCCc3c[nH]c4ccccc34)n2)CC1	10.1016/j.ejmech.2021.113931
		CHEMBL5184538	190856	0	None	-12	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	515	12	4	9	3.6	COc1ccccc1N1CCN(CCCCNc2nc(N)nc(NCCc3c[nH]c4ccccc34)n2)CC1	10.1016/j.ejmech.2021.113931
		888197	76735	4	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	241	5	0	2	3.3	CN(C)CCOc1ccccc1-c1ccccc1	10.1016/j.bmc.2010.01.035
		CHEMBL20666	76735	4	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	241	5	0	2	3.3	CN(C)CCOc1ccccc1-c1ccccc1	10.1016/j.bmc.2010.01.035
		10430623	18675	24	None	-1412	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cells	ChEMBL	392	3	2	5	3.0	O=S(=O)(c1cccc2ccccc12)c1n[nH]c2ccc(N3CCNCC3)cc12	10.1021/jm1007825
		CHEMBL1277105	18675	24	None	-1412	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cells	ChEMBL	392	3	2	5	3.0	O=S(=O)(c1cccc2ccccc12)c1n[nH]c2ccc(N3CCNCC3)cc12	10.1021/jm1007825
		162669046	183743	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	395	8	1	4	4.4	COc1ccccc1N1CCN(CCCC(=O)Nc2cccc(C(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4789585	183743	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	395	8	1	4	4.4	COc1ccccc1N1CCN(CCCC(=O)Nc2cccc(C(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4803681	183743	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	395	8	1	4	4.4	COc1ccccc1N1CCN(CCCC(=O)Nc2cccc(C(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
		86288950	112643	0	None	-3	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	452	8	0	4	3.9	CN1C(=O)N(CCCCCN2CCN(c3ccccc3F)CC2)C(C)(c2ccccc2)C1=O	10.1016/j.ejmech.2014.01.065
		CHEMBL3233666	112643	0	None	-3	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	452	8	0	4	3.9	CN1C(=O)N(CCCCCN2CCN(c3ccccc3F)CC2)C(C)(c2ccccc2)C1=O	10.1016/j.ejmech.2014.01.065
		CHEMBL3302931	112643	0	None	-3	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	452	8	0	4	3.9	CN1C(=O)N(CCCCCN2CCN(c3ccccc3F)CC2)C(C)(c2ccccc2)C1=O	10.1016/j.ejmech.2014.01.065
		91937907	167640	0	None	17	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hrDisplacement of [3H]5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr	ChEMBL	368	7	0	4	4.2	COc1ccccc1N1CCN(CCCOc2c(C)cc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
		CHEMBL4218586	167640	0	None	17	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hrDisplacement of [3H]5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr	ChEMBL	368	7	0	4	4.2	COc1ccccc1N1CCN(CCCOc2c(C)cc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
		CHEMBL4301638	167640	0	None	17	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hrDisplacement of [3H]5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr	ChEMBL	368	7	0	4	4.2	COc1ccccc1N1CCN(CCCOc2c(C)cc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
		122483290	138099	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.9	O=C(CCCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765511	138099	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.9	O=C(CCCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765847	138099	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.9	O=C(CCCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		44461064	205589	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	287	4	0	4	2.3	COc1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
		CHEMBL81449	205589	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	287	4	0	4	2.3	COc1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
		168268929	190030	0	None	-3	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	456	9	5	7	4.4	Nc1nc(NCCNc2cccc(Cl)c2Cl)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
		CHEMBL5171734	190030	0	None	-3	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	456	9	5	7	4.4	Nc1nc(NCCNc2cccc(Cl)c2Cl)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
		12005903	51224	13	None	-117	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	482	5	0	7	4.0	CCS(=O)(=O)c1nc(S(=O)(=O)c2ccc(Cl)cc2)c(N2CCc3ccccc3C2)s1	10.1016/j.bmcl.2015.03.049
		CHEMBL1580288	51224	13	None	-117	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	482	5	0	7	4.0	CCS(=O)(=O)c1nc(S(=O)(=O)c2ccc(Cl)cc2)c(N2CCc3ccccc3C2)s1	10.1016/j.bmcl.2015.03.049
		44460739	205549	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	361	3	0	3	3.6	Brc1ccc2c(ccn2CCN2CCN3CCCCC3C2)c1	10.1016/s0960-894x(02)00438-9
		CHEMBL81069	205549	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	361	3	0	3	3.6	Brc1ccc2c(ccn2CCN2CCN3CCCCC3C2)c1	10.1016/s0960-894x(02)00438-9
		42626289	148079	0	None	-5	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	379	7	0	4	3.3	COc1ccccc1N1CCN(CCCCN2Cc3ccccc3C2=O)CC1	10.1021/jm8014553
		CHEMBL393492	148079	0	None	-5	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	379	7	0	4	3.3	COc1ccccc1N1CCN(CCCCN2Cc3ccccc3C2=O)CC1	10.1021/jm8014553
		11292933	56394	45	None	-794	9	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	415	5	1	4	3.4	Cc1ccc2c(N3CCN(CCc4cccc(N5CCNC5=O)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1631540	56394	45	None	-794	9	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	415	5	1	4	3.4	Cc1ccc2c(N3CCN(CCc4cccc(N5CCNC5=O)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL5085390	214964	0	None	-12	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		C[C@H]1C[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)CN1CCCc1noc2cc(F)ccc12	10.1021/acs.jmedchem.1c00497
		155528865	171389	0	None	-33	7	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	347	6	0	3	4.0	Fc1ccc(CCCCN2CCN(c3ccc(Cl)cn3)CC2)cc1	10.1016/j.bmc.2020.115943
		CHEMBL4462108	171389	0	None	-33	7	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	347	6	0	3	4.0	Fc1ccc(CCCCN2CCN(c3ccc(Cl)cn3)CC2)cc1	10.1016/j.bmc.2020.115943
		162645252	183625	0	None	-2	7	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	389	7	0	3	5.0	Fc1ccc(CCCCN2CCN(c3cccc(-c4ccccc4)n3)CC2)cc1	10.1016/j.bmc.2020.115943
		CHEMBL4743284	183625	0	None	-2	7	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	389	7	0	3	5.0	Fc1ccc(CCCCN2CCN(c3cccc(-c4ccccc4)n3)CC2)cc1	10.1016/j.bmc.2020.115943
		CHEMBL4802393	183625	0	None	-2	7	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	389	7	0	3	5.0	Fc1ccc(CCCCN2CCN(c3cccc(-c4ccccc4)n3)CC2)cc1	10.1016/j.bmc.2020.115943
		1150	3878	121	None	-6	25	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1016/j.ejmech.2019.111705
		125	3878	121	None	-6	25	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1016/j.ejmech.2019.111705
		CHEMBL6640	3878	121	None	-6	25	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1016/j.ejmech.2019.111705
		DB08653	3878	121	None	-6	25	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1016/j.ejmech.2019.111705
		122483290	138099	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.9	O=C(CCCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765511	138099	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.9	O=C(CCCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765847	138099	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.9	O=C(CCCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		145967457	164351	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	428	7	1	4	3.5	O=S(=O)(NC1CCN(CCOc2cccc(C(F)(F)F)c2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
		CHEMBL4212698	164351	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	428	7	1	4	3.5	O=S(=O)(NC1CCN(CCOc2cccc(C(F)(F)F)c2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
		12843124	10264	27	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	177	1	1	2	1.5	COc1ccc2c(c1)CC[C@@H](N)C2	10.1021/jm030826m
		CHEMBL1161325	10264	27	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	177	1	1	2	1.5	COc1ccc2c(c1)CC[C@@H](N)C2	10.1021/jm030826m
		9891002	107408	0	None	-1584	7	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligand	ChEMBL	472	4	2	6	4.6	Cc1sc2ccc(Cl)cc2c1S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1	10.1016/s0960-894x(01)00558-3
		CHEMBL318018	107408	0	None	-1584	7	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligand	ChEMBL	472	4	2	6	4.6	Cc1sc2ccc(Cl)cc2c1S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1	10.1016/s0960-894x(01)00558-3
		10785644	97104	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	374	6	0	3	4.0	C[C@@H](CCN1CCC[C@@H](C)C1)N(C)S(=O)(=O)c1cccc2ccccc12	10.1021/jm970519e
		CHEMBL267543	97104	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	374	6	0	3	4.0	C[C@@H](CCN1CCC[C@@H](C)C1)N(C)S(=O)(=O)c1cccc2ccccc12	10.1021/jm970519e
		10785644	97104	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	C[C@@H](CCN1CCC[C@@H](C)C1)N(C)S(=O)(=O)c1cccc2ccccc12	10.1016/s0960-894x(00)00166-9
		CHEMBL267543	97104	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	C[C@@H](CCN1CCC[C@@H](C)C1)N(C)S(=O)(=O)c1cccc2ccccc12	10.1016/s0960-894x(00)00166-9
		44368383	119717	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	373	6	0	3	4.8	CC([C@@H](C)CCN1CCC[C@@H](C)C1)S(=O)(=O)c1cccc2ccccc12	10.1021/jm030841r
		CHEMBL347511	119717	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	373	6	0	3	4.8	CC([C@@H](C)CCN1CCC[C@@H](C)C1)S(=O)(=O)c1cccc2ccccc12	10.1021/jm030841r
		127050632	140743	0	None	-89	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	454	6	1	5	4.7	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3cc(Cl)ccc3s1)CC2	10.1016/j.bmc.2016.06.011
		CHEMBL3818124	140743	0	None	-89	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	454	6	1	5	4.7	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3cc(Cl)ccc3s1)CC2	10.1016/j.bmc.2016.06.011
		127049059	140813	0	None	-154	7	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	404	6	1	5	3.6	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3o1)CC2	10.1016/j.bmc.2016.06.011
		CHEMBL3818935	140813	0	None	-154	7	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	404	6	1	5	3.6	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3o1)CC2	10.1016/j.bmc.2016.06.011
		162663829	183720	0	None	-2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	439	8	2	5	4.6	COc1ccccc1N1CCN(CCCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4779965	183720	0	None	-2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	439	8	2	5	4.6	COc1ccccc1N1CCN(CCCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4803379	183720	0	None	-2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	439	8	2	5	4.6	COc1ccccc1N1CCN(CCCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1	10.1016/j.ejmech.2020.112437
		155528865	171389	0	None	-33	7	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	347	6	0	3	4.0	Fc1ccc(CCCCN2CCN(c3ccc(Cl)cn3)CC2)cc1	10.1016/j.bmc.2020.115943
		CHEMBL4462108	171389	0	None	-33	7	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	347	6	0	3	4.0	Fc1ccc(CCCCN2CCN(c3ccc(Cl)cn3)CC2)cc1	10.1016/j.bmc.2020.115943
		164623862	186005	0	None	-79	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	351	6	0	5	2.8	O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc21	10.1016/j.ejmech.2021.113243
		CHEMBL4870361	186005	0	None	-79	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	351	6	0	5	2.8	O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc21	10.1016/j.ejmech.2021.113243
		127050632	140743	0	None	-89	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	454	6	1	5	4.7	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3cc(Cl)ccc3s1)CC2	10.1016/j.bmc.2016.06.011
		CHEMBL3818124	140743	0	None	-89	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	454	6	1	5	4.7	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3cc(Cl)ccc3s1)CC2	10.1016/j.bmc.2016.06.011
		44393022	64838	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	335	7	2	3	5.0	C[C@H](Nc1cncc(NCCc2ccc(F)cc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		CHEMBL182006	64838	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	335	7	2	3	5.0	C[C@H](Nc1cncc(NCCc2ccc(F)cc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		168273329	190568	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	368	6	0	3	3.5	CC1CCN(CCC[C@H]2CCCN2S(=O)(=O)c2ccc(F)cc2)CC1	10.1021/acs.jmedchem.2c00633
		CHEMBL5180129	190568	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	368	6	0	3	3.5	CC1CCN(CCC[C@H]2CCCN2S(=O)(=O)c2ccc(F)cc2)CC1	10.1021/acs.jmedchem.2c00633
		10106205	207137	1	None	1	4	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	251	2	2	3	3.0	Cc1c(NC2=NCCN2)cccc1-c1ccccc1	10.1021/jm030030n
		CHEMBL92221	207137	1	None	1	4	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	251	2	2	3	3.0	Cc1c(NC2=NCCN2)cccc1-c1ccccc1	10.1021/jm030030n
		44461066	104153	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	361	4	0	3	3.6	Brc1ccc2ccn(CCN3CCCN(C4CC4)CC3)c2c1	10.1016/s0960-894x(02)00438-9
		CHEMBL309523	104153	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	361	4	0	3	3.6	Brc1ccc2ccn(CCN3CCCN(C4CC4)CC3)c2c1	10.1016/s0960-894x(02)00438-9
		127026751	137680	0	None	23	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	446	8	1	4	4.3	O=S(=O)(NC1CCN(CCOc2ccccc2C2CCCC2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2015.11.040
		CHEMBL3758622	137680	0	None	23	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	446	8	1	4	4.3	O=S(=O)(NC1CCN(CCOc2ccccc2C2CCCC2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2015.11.040
		90178632	145428	0	None	9	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	468	10	1	5	4.1	N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		CHEMBL3914155	145428	0	None	9	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	468	10	1	5	4.1	N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		134151980	153190	0	None	8	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	570	14	1	6	5.1	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccc(OCCN2CCOCC2)cc1	10.1016/j.ejmech.2016.05.005
		CHEMBL3977072	153190	0	None	8	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	570	14	1	6	5.1	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccc(OCCN2CCOCC2)cc1	10.1016/j.ejmech.2016.05.005
		71456783	81437	0	None	1	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	418	7	1	4	3.1	O=S(=O)(NC1CCN(CCOc2cccc3c2CCCC3)C1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159480	81437	0	None	1	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	418	7	1	4	3.1	O=S(=O)(NC1CCN(CCOc2cccc3c2CCCC3)C1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
		71449644	81441	0	None	-1	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	436	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2cccc3c2CCCC3)C1)c1cc(F)ccc1F	10.1016/j.ejmech.2012.07.043
		CHEMBL2159484	81441	0	None	-1	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	436	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2cccc3c2CCCC3)C1)c1cc(F)ccc1F	10.1016/j.ejmech.2012.07.043
		118731357	118193	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	516	9	0	4	5.0	O=C([C@@H]1CCCN1C(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
		CHEMBL3409040	118193	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	516	9	0	4	5.0	O=C([C@@H]1CCCN1C(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
		156016485	177773	0	None	-15	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	475	8	0	7	4.7	O=c1n(CCCCCCN2CCN(c3nsc4ccccc34)CC2)c2cccc3c2n1CCC3	10.1016/j.bmc.2020.115459
		CHEMBL4642981	177773	0	None	-15	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	475	8	0	7	4.7	O=c1n(CCCCCCN2CCN(c3nsc4ccccc34)CC2)c2cccc3c2n1CCC3	10.1016/j.bmc.2020.115459
		57384073	77205	0	None	-19	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	512	9	0	5	4.4	COc1ccccc1N1CCN(CCCCN2C(=O)N(C)C(=O)C2(c2ccccc2)c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
		CHEMBL2079256	77205	0	None	-19	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	512	9	0	5	4.4	COc1ccccc1N1CCN(CCCCN2C(=O)N(C)C(=O)C2(c2ccccc2)c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
		139488539	171424	0	None	19	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	307	2	1	2	4.0	CCn1cncc1-c1c[nH]c2ccc(Br)c(F)c12	10.1016/j.ejmech.2019.03.017
		CHEMBL4462820	171424	0	None	19	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	307	2	1	2	4.0	CCn1cncc1-c1c[nH]c2ccc(Br)c(F)c12	10.1016/j.ejmech.2019.03.017
		156009593	177169	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	303	2	0	1	4.6	CN(C)C1CCc2c(cccc2-c2ccc(F)cc2Cl)C1	10.1016/j.bmc.2019.115262
		CHEMBL4634558	177169	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	303	2	0	1	4.6	CN(C)C1CCc2c(cccc2-c2ccc(F)cc2Cl)C1	10.1016/j.bmc.2019.115262
		142601328	185003	0	None	39	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4854605	185003	0	None	39	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		155557720	174647	0	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	494	10	1	7	3.2	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
		CHEMBL4558286	174647	0	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	494	10	1	7	3.2	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
		54758297	66007	0	None	15	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	349	6	1	3	3.7	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm200547z
		CHEMBL1836856	66007	0	None	15	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	349	6	1	3	3.7	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm200547z
		135367857	164604	0	None	1	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		CHEMBL4215875	164604	0	None	1	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		132604118	181993	0	None	5	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	420	8	1	7	2.7	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
		CHEMBL4780452	181993	0	None	5	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	420	8	1	7	2.7	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
		10106205	207137	1	None	-1	4	Rat	7.8	pKi	=	7.8	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	251	2	2	3	3.0	Cc1c(NC2=NCCN2)cccc1-c1ccccc1	10.1021/jm030826m
		CHEMBL92221	207137	1	None	-1	4	Rat	7.8	pKi	=	7.8	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	251	2	2	3	3.0	Cc1c(NC2=NCCN2)cccc1-c1ccccc1	10.1021/jm030826m
		135367857	164604	0	None	1	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		CHEMBL4215875	164604	0	None	1	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		10106205	207137	1	None	-1	4	Rat	7.8	pKi	=	7.8	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	251	2	2	3	3.0	Cc1c(NC2=NCCN2)cccc1-c1ccccc1	10.1016/s0960-894x(02)00925-3
		CHEMBL92221	207137	1	None	-1	4	Rat	7.8	pKi	=	7.8	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	251	2	2	3	3.0	Cc1c(NC2=NCCN2)cccc1-c1ccccc1	10.1016/s0960-894x(02)00925-3
		11025015	50199	0	None	-3	2	Rat	7.8	pKi	=	7.8	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	368	8	1	5	3.6	COc1ccccc1N1CCN(CCCCC(=O)c2ccccc2O)CC1	10.1021/jm020994z
		CHEMBL157081	50199	0	None	-3	2	Rat	7.8	pKi	=	7.8	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	368	8	1	5	3.6	COc1ccccc1N1CCN(CCCCC(=O)c2ccccc2O)CC1	10.1021/jm020994z
		25107518	187284	0	None	-20	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-SB-26997 from human 5-HT7A receptor expressed in HEK293 cell membranes after 60 mins by microbeta counting analysisDisplacement of [3H]-SB-26997 from human 5-HT7A receptor expressed in HEK293 cell membranes after 60 mins by microbeta counting analysis	ChEMBL	441	10	1	3	5.4	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccccc1	10.1016/j.ejmech.2016.05.005
		CHEMBL492871	187284	0	None	-20	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-SB-26997 from human 5-HT7A receptor expressed in HEK293 cell membranes after 60 mins by microbeta counting analysisDisplacement of [3H]-SB-26997 from human 5-HT7A receptor expressed in HEK293 cell membranes after 60 mins by microbeta counting analysis	ChEMBL	441	10	1	3	5.4	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccccc1	10.1016/j.ejmech.2016.05.005
		44324628	112375	0	None	-	1	Rat	7.8	pKi	=	7.8	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	257	2	2	4	3.1	Cc1c(NC2=NCCN2)cccc1-c1cccs1	10.1016/s0960-894x(02)00925-3
		CHEMBL329548	112375	0	None	-	1	Rat	7.8	pKi	=	7.8	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	257	2	2	4	3.1	Cc1c(NC2=NCCN2)cccc1-c1cccs1	10.1016/s0960-894x(02)00925-3
		90656695	110996	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	353	8	1	4	3.8	CN(CCCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262429	110996	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	353	8	1	4	3.8	CN(CCCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		168282260	191003	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human 5-HT7 receptor transfected by pcDNA3.1(+) vector in HEK293 cells assessed as inhibition constant by Cheng-Prusoff equation analysisBinding affinity to human 5-HT7 receptor transfected by pcDNA3.1(+) vector in HEK293 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	232	3	0	4	2.6	COc1ccc(-c2c([N+](=O)[O-])ccn2C)cc1	10.1021/acs.jmedchem.2c00633
		CHEMBL5186652	191003	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human 5-HT7 receptor transfected by pcDNA3.1(+) vector in HEK293 cells assessed as inhibition constant by Cheng-Prusoff equation analysisBinding affinity to human 5-HT7 receptor transfected by pcDNA3.1(+) vector in HEK293 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	232	3	0	4	2.6	COc1ccc(-c2c([N+](=O)[O-])ccn2C)cc1	10.1021/acs.jmedchem.2c00633
		11595790	66001	0	None	6	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	368	6	1	4	3.2	O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2ccccn2)CC1	10.1021/jm200547z
		CHEMBL1836790	66001	0	None	6	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	368	6	1	4	3.2	O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2ccccn2)CC1	10.1021/jm200547z
		11646498	102504	0	None	-7	2	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	375	11	1	5	2.3	CCOc1ccccc1OCCNCCCCN1C(=O)C2CCCN2C1=O	10.1021/jm400766k
		CHEMBL2431051	102504	0	None	-7	2	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	375	11	1	5	2.3	CCOc1ccccc1OCCNCCCCN1C(=O)C2CCCN2C1=O	10.1021/jm400766k
		CHEMBL3040382	102504	0	None	-7	2	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	375	11	1	5	2.3	CCOc1ccccc1OCCNCCCCN1C(=O)C2CCCN2C1=O	10.1021/jm400766k
		9803482	204271	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	443	7	1	4	5.0	COCn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
		CHEMBL71224	204271	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	443	7	1	4	5.0	COCn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
		127051845	140729	0	None	1	9	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	309	6	0	3	3.7	COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3817898	140729	0	None	1	9	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	309	6	0	3	3.7	COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		50878551	90745	61	None	1	18	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
		CHEMBL2391541	90745	61	None	1	18	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
		156012890	177443	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	285	2	0	1	4.4	CN(C)[C@H]1CCc2c(cccc2-c2ccc(Cl)cc2)C1	10.1016/j.bmc.2019.115262
		CHEMBL4638770	177443	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	285	2	0	1	4.4	CN(C)[C@H]1CCc2c(cccc2-c2ccc(Cl)cc2)C1	10.1016/j.bmc.2019.115262
		162645252	183625	0	None	-2	7	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	389	7	0	3	5.0	Fc1ccc(CCCCN2CCN(c3cccc(-c4ccccc4)n3)CC2)cc1	10.1016/j.bmc.2020.115943
		CHEMBL4743284	183625	0	None	-2	7	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	389	7	0	3	5.0	Fc1ccc(CCCCN2CCN(c3cccc(-c4ccccc4)n3)CC2)cc1	10.1016/j.bmc.2020.115943
		CHEMBL4802393	183625	0	None	-2	7	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	389	7	0	3	5.0	Fc1ccc(CCCCN2CCN(c3cccc(-c4ccccc4)n3)CC2)cc1	10.1016/j.bmc.2020.115943
		44424661	144547	0	None	-8	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	484	10	0	10	1.8	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2007.05.017
		CHEMBL390734	144547	0	None	-8	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	484	10	0	10	1.8	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2007.05.017
		118706287	120531	0	None	-14	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccc(Cl)cc1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3310114	120531	0	None	-14	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccc(Cl)cc1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3545466	120531	0	None	-14	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccc(Cl)cc1-2	10.1016/j.bmc.2014.05.027
		42625359	186847	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	348	6	0	2	4.2	O=C1Cc2ccccc2N1CCCCN1CCC(c2ccccc2)CC1	10.1021/jm8014553
		CHEMBL489448	186847	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	348	6	0	2	4.2	O=C1Cc2ccccc2N1CCCCN1CCC(c2ccccc2)CC1	10.1021/jm8014553
		136216703	78905	0	None	-79	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity against 5-hydroxytryptamine 7 receptorBinding affinity against 5-hydroxytryptamine 7 receptor	ChEMBL	482	2	4	7	4.0	N[C@H]1CCCC[C@@H]1NC(=O)c1c2c(c3c4c(ncnc14)-c1ccccc1C3=O)N[C@@H]1CCCC[C@H]1N2	10.1016/s0960-894x(99)00075-x
		CHEMBL2112936	78905	0	None	-79	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity against 5-hydroxytryptamine 7 receptorBinding affinity against 5-hydroxytryptamine 7 receptor	ChEMBL	482	2	4	7	4.0	N[C@H]1CCCC[C@@H]1NC(=O)c1c2c(c3c4c(ncnc14)-c1ccccc1C3=O)N[C@@H]1CCCC[C@H]1N2	10.1016/s0960-894x(99)00075-x
		9796627	96653	0	None	-54	7	Human	5.8	pKi	=	5.8	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	308	4	1	4	3.1	CN(C)CCc1cn(C(=O)c2ccccc2)c2ccc(O)cc12	10.1021/jm010943m
		CHEMBL263700	96653	0	None	-54	7	Human	5.8	pKi	=	5.8	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	308	4	1	4	3.1	CN(C)CCc1cn(C(=O)c2ccccc2)c2ccc(O)cc12	10.1021/jm010943m
		15560577	185341	9	None	-31	10	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay	ChEMBL	398	5	1	5	3.8	CC[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
		CHEMBL4859858	185341	9	None	-31	10	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay	ChEMBL	398	5	1	5	3.8	CC[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
		23906630	117929	5	None	-2	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	404	3	1	2	2.9	O=S(=O)(c1ccc(F)cc1)N1CC=c2ccccc2=C1c1c[nH]c2ccccc12	10.1016/j.bmcl.2015.03.049
		CHEMBL3403333	117929	5	None	-2	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	404	3	1	2	2.9	O=S(=O)(c1ccc(F)cc1)N1CC=c2ccccc2=C1c1c[nH]c2ccccc12	10.1016/j.bmcl.2015.03.049
		155566439	175798	0	None	-69	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	314	4	1	7	1.1	Cc1ccc(OCc2nc(N)nc(N3CCN(C)CC3)n2)cc1	10.1016/j.ejmech.2019.06.022
		CHEMBL4584325	175798	0	None	-69	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	314	4	1	7	1.1	Cc1ccc(OCc2nc(N)nc(N3CCN(C)CC3)n2)cc1	10.1016/j.ejmech.2019.06.022
		45273807	195804	0	None	28	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	400	6	3	3	2.7	Cc1cccc(S(=O)(=O)NCCNC(=N)N2CCC(c3ccccc3)CC2)c1	10.1016/j.bmcl.2009.06.038
		CHEMBL558025	195804	0	None	28	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	400	6	3	3	2.7	Cc1cccc(S(=O)(=O)NCCNC(=N)N2CCC(c3ccccc3)CC2)c1	10.1016/j.bmcl.2009.06.038
		71451441	81373	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	436	6	1	5	3.6	O=C(NC1CCN(CCOc2cccc(Cl)c2Cl)C1)c1ccc2c(c1)OCCO2	10.1016/j.ejmech.2012.07.043
		CHEMBL2159320	81373	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	436	6	1	5	3.6	O=C(NC1CCN(CCOc2cccc(Cl)c2Cl)C1)c1ccc2c(c1)OCCO2	10.1016/j.ejmech.2012.07.043
		155552826	174092	0	None	37	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	269	3	1	4	2.8	CCn1cncc1-c1c[nH]c2ccc(C(=O)OC)cc12	10.1039/C8MD00313K
		CHEMBL4544802	174092	0	None	37	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	269	3	1	4	2.8	CCn1cncc1-c1c[nH]c2ccc(C(=O)OC)cc12	10.1039/C8MD00313K
		53248361	62082	0	None	-104	7	Human	6.8	pKi	=	6.8	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	568	7	0	5	3.2	COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52I)c2ccccn2)CC1	10.1021/jm1009956
		CHEMBL1774991	62082	0	None	-104	7	Human	6.8	pKi	=	6.8	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	568	7	0	5	3.2	COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52I)c2ccccn2)CC1	10.1021/jm1009956
		90656686	110983	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	366	7	1	4	3.3	CC(=O)Nc1cccc(N(C)CCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262416	110983	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	366	7	1	4	3.3	CC(=O)Nc1cccc(N(C)CCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
		90656679	110982	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	387	6	0	3	4.1	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(Br)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262415	110982	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	387	6	0	3	4.1	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(Br)c1	10.1016/j.ejmech.2014.04.034
		90656674	110972	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	311	5	1	4	2.7	CN(CCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262399	110972	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	311	5	1	4	2.7	CN(CCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		46233351	199175	0	None	4	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	270	5	0	3	3.3	Cc1cccc(C)c1-c1cccc(OCCN(C)C)n1	10.1016/j.bmc.2010.01.035
		CHEMBL589524	199175	0	None	4	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	270	5	0	3	3.3	Cc1cccc(C)c1-c1cccc(OCCN(C)C)n1	10.1016/j.bmc.2010.01.035
		127027390	137839	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	418	7	0	4	3.5	CC(C)c1ccccc1OCCN1CC2CC1CN2S(=O)(=O)c1ccc(F)cc1	10.1016/j.ejmech.2015.11.040
		CHEMBL3759927	137839	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	418	7	0	4	3.5	CC(C)c1ccccc1OCCN1CC2CC1CN2S(=O)(=O)c1ccc(F)cc1	10.1016/j.ejmech.2015.11.040
		168293886	192180	0	None	-2	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	488	8	0	4	4.5	O=S1(=O)N(CCCCCCN2CCN(c3cccc(Cl)c3)CC2)c2cccc3c2N1CCC3	10.1016/j.ejmech.2022.114319
		CHEMBL5204088	192180	0	None	-2	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	488	8	0	4	4.5	O=S1(=O)N(CCCCCCN2CCN(c3cccc(Cl)c3)CC2)c2cccc3c2N1CCC3	10.1016/j.ejmech.2022.114319
		155531065	171613	0	None	-229	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	332	6	3	3	4.5	Oc1ccc(-c2ccc(CNCCc3c[nH]c4ccccc34)o2)cc1	10.1016/j.ejmech.2019.111857
		CHEMBL4465414	171613	0	None	-229	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	332	6	3	3	4.5	Oc1ccc(-c2ccc(CNCCc3c[nH]c4ccccc34)o2)cc1	10.1016/j.ejmech.2019.111857
		1355	2011	88	None	-14	16	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT7BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7BR (unknown origin) assessed as inhibition constant	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.ejmech.2022.114319
		142	2011	88	None	-14	16	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT7BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7BR (unknown origin) assessed as inhibition constant	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.ejmech.2022.114319
		CHEMBL478	2011	88	None	-14	16	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT7BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7BR (unknown origin) assessed as inhibition constant	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.ejmech.2022.114319
		DB12110	2011	88	None	-14	16	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT7BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7BR (unknown origin) assessed as inhibition constant	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.ejmech.2022.114319
		44461052	205876	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	391	4	0	3	4.5	CC(C)(C)CN1CCCN(CCn2ccc3ccc(Br)cc32)CC1	10.1016/s0960-894x(02)00438-9
		CHEMBL83802	205876	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	391	4	0	3	4.5	CC(C)(C)CN1CCCN(CCn2ccc3ccc(Br)cc32)CC1	10.1016/s0960-894x(02)00438-9
		90654689	110075	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	404	8	1	5	2.2	CSc1ccccc1N1CCN(CCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235726	110075	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	404	8	1	5	2.2	CSc1ccccc1N1CCN(CCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
		127028634	137854	0	None	4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	392	7	1	4	3.0	Cc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
		CHEMBL3760121	137854	0	None	4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	392	7	1	4	3.0	Cc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
		44424671	143464	0	None	-2	2	Rat	4.8	pKi	=	4.8	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	369	4	1	7	0.2	Cn1c(=O)c2c([nH]c(=O)n2CCCN2CCc3ccccc3C2)n(C)c1=O	10.1016/j.bmc.2007.05.017
		CHEMBL389842	143464	0	None	-2	2	Rat	4.8	pKi	=	4.8	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	369	4	1	7	0.2	Cn1c(=O)c2c([nH]c(=O)n2CCCN2CCc3ccccc3C2)n(C)c1=O	10.1016/j.bmc.2007.05.017
		137650961	157333	0	None	3	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	482	6	0	5	4.0	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3cccc(F)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
		CHEMBL4077538	157333	0	None	3	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	482	6	0	5	4.0	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3cccc(F)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
		145982506	165395	0	None	-11	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	489	6	1	5	4.1	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2cccc3[nH]ccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4238029	165395	0	None	-11	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	489	6	1	5	4.1	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2cccc3[nH]ccc23)CC1	10.1016/j.ejmech.2018.01.002
		145987559	167148	0	None	26	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	441	7	2	5	2.5	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCC(Oc3ccccc3)CC2)C1=O	10.1039/C8MD00168E
		CHEMBL4290738	167148	0	None	26	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	441	7	2	5	2.5	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCC(Oc3ccccc3)CC2)C1=O	10.1039/C8MD00168E
		44341131	9475	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	393	5	1	6	2.8	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3oc(O)nc3c2)CC1	10.1016/s0960-894x(02)00690-x
		CHEMBL111956	9475	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	393	5	1	6	2.8	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3oc(O)nc3c2)CC1	10.1016/s0960-894x(02)00690-x
		168291978	192013	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	482	6	3	7	4.2	Nc1nc(NCCc2c[nH]c3ccccc23)nc(N2CCN(c3cccc(Cl)c3Cl)CC2)n1	10.1016/j.ejmech.2021.113931
		CHEMBL5201719	192013	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	482	6	3	7	4.2	Nc1nc(NCCc2c[nH]c3ccccc23)nc(N2CCN(c3cccc(Cl)c3Cl)CC2)n1	10.1016/j.ejmech.2021.113931
		118728527	117723	0	None	-7	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	424	8	0	6	4.1	Cc1sc2ncn(CCCCCN3CCN(Cc4ccccc4)CC3)c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
		CHEMBL3401490	117723	0	None	-7	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	424	8	0	6	4.1	Cc1sc2ncn(CCCCCN3CCN(Cc4ccccc4)CC3)c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
		71678345	89683	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	396	4	0	2	5.7	FC(F)(F)c1cccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)c1	10.1016/j.bmc.2013.02.038
		CHEMBL2376455	89683	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	396	4	0	2	5.7	FC(F)(F)c1cccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)c1	10.1016/j.bmc.2013.02.038
		24901425	62594	0	None	-10	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	391	6	2	5	4.5	N#Cc1ccc(N2CCC(NCCC(O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
		CHEMBL1782811	62594	0	None	-10	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	391	6	2	5	4.5	N#Cc1ccc(N2CCC(NCCC(O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
		44460639	163341	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	285	4	0	3	2.8	CCc1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
		CHEMBL419101	163341	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	285	4	0	3	2.8	CCc1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
		155569022	176436	0	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.5	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4592962	176436	0	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.5	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4596261	176436	0	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.5	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
		71678345	89683	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	396	4	0	2	5.7	FC(F)(F)c1cccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)c1	10.1016/j.bmc.2013.02.038
		CHEMBL2376455	89683	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	396	4	0	2	5.7	FC(F)(F)c1cccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)c1	10.1016/j.bmc.2013.02.038
		168268997	189971	0	None	-23	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	410	7	3	8	2.4	Nc1nc(N)nc(NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n1	10.1016/j.ejmech.2021.113931
		CHEMBL5170808	189971	0	None	-23	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	410	7	3	8	2.4	Nc1nc(N)nc(NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n1	10.1016/j.ejmech.2021.113931
		168277941	190683	0	None	-7	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	374	9	2	4	1.8	NS(=O)(=O)NCCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2022.114319
		CHEMBL5181868	190683	0	None	-7	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	374	9	2	4	1.8	NS(=O)(=O)NCCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2022.114319
		155519516	176358	0	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	5.8	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4447659	176358	0	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	5.8	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4595677	176358	0	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	5.8	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2019.06.028
		53322759	57012	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	356	3	1	2	4.9	FC(F)(F)c1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
		CHEMBL1644272	57012	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	356	3	1	2	4.9	FC(F)(F)c1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
		145971390	164634	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1cccc(Cl)c1	10.1021/acs.jmedchem.8b00828
		CHEMBL4216244	164634	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1cccc(Cl)c1	10.1021/acs.jmedchem.8b00828
		71451345	81171	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	398	6	1	3	4.4	CC(C)(C)c1ccccc1OCCN1CCC(NC(=O)c2cccc(F)c2)CC1	10.1016/j.ejmech.2012.07.043
		CHEMBL2158037	81171	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	398	6	1	3	4.4	CC(C)(C)c1ccccc1OCCN1CCC(NC(=O)c2cccc(F)c2)CC1	10.1016/j.ejmech.2012.07.043
		137642224	158091	0	None	-758	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	323	3	2	6	1.3	CN1CCN(c2nc(N)nc(Cc3c[nH]c4ccccc34)n2)CC1	10.1016/j.ejmech.2022.114645
		CHEMBL4086515	158091	0	None	-758	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	323	3	2	6	1.3	CN1CCN(c2nc(N)nc(Cc3c[nH]c4ccccc34)n2)CC1	10.1016/j.ejmech.2022.114645
		127027389	137793	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	434	7	0	4	4.0	CC(C)c1ccccc1OCCN1CC2CC1CN2S(=O)(=O)c1cccc(Cl)c1	10.1016/j.ejmech.2015.11.040
		CHEMBL3759570	137793	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	434	7	0	4	4.0	CC(C)c1ccccc1OCCN1CC2CC1CN2S(=O)(=O)c1cccc(Cl)c1	10.1016/j.ejmech.2015.11.040
		118728506	117703	0	None	-4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	414	8	2	4	3.4	NC(=O)c1ccccc1NC(=O)CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2015.02.042
		CHEMBL3401469	117703	0	None	-4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	414	8	2	4	3.4	NC(=O)c1ccccc1NC(=O)CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2015.02.042
		42618261	181551	0	None	-6	2	Human	6.8	pKi	=	6.8	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	472	8	0	7	4.0	COc1ccc(-n2c(=O)n(CCCN3CCN(c4ccccc4OC)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2009.02.008
		CHEMBL476616	181551	0	None	-6	2	Human	6.8	pKi	=	6.8	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	472	8	0	7	4.0	COc1ccc(-n2c(=O)n(CCCN3CCN(c4ccccc4OC)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2009.02.008
		56850665	71505	0	None	-11	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	334	7	1	5	2.4	O=C1CSC(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
		CHEMBL1926749	71505	0	None	-11	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	334	7	1	5	2.4	O=C1CSC(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
		CHEMBL1962697	71505	0	None	-11	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	334	7	1	5	2.4	O=C1CSC(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
		162659577	181358	0	None	-17	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	475	7	1	6	4.7	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(Cl)cc2s1	10.1016/j.ejmech.2020.112149
		CHEMBL4763106	181358	0	None	-17	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	475	7	1	6	4.7	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(Cl)cc2s1	10.1016/j.ejmech.2020.112149
		44324402	13439	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	276	2	2	4	2.9	Cc1c(NC2=NCCN2)cccc1-c1cccc(C#N)c1	10.1016/s0960-894x(02)00925-3
		CHEMBL1192985	13439	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	276	2	2	4	2.9	Cc1c(NC2=NCCN2)cccc1-c1cccc(C#N)c1	10.1016/s0960-894x(02)00925-3
		CHEMBL544315	13439	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	276	2	2	4	2.9	Cc1c(NC2=NCCN2)cccc1-c1cccc(C#N)c1	10.1016/s0960-894x(02)00925-3
		CHEMBL5275931	193877	0	None	-26	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis	ChEMBL	629	10	0	8	5.4	O=C1CC2CCc3ccsc3C2=NN1CCCCCN1CCN(Cc2cccc3c2ccn3S(=O)(=O)c2ccccc2)CC1	10.1016/j.bmc.2023.117256
		71727066	91265	0	None	-1	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	338	3	0	5	2.7	COc1ccc2c(=O)c3cc(CN4CCN(C)CC4)ccc3oc2c1	10.1016/j.bmcl.2013.05.062
		CHEMBL2401936	91265	0	None	-1	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	338	3	0	5	2.7	COc1ccc2c(=O)c3cc(CN4CCN(C)CC4)ccc3oc2c1	10.1016/j.bmcl.2013.05.062
		CHEMBL3215930	91265	0	None	-1	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	338	3	0	5	2.7	COc1ccc2c(=O)c3cc(CN4CCN(C)CC4)ccc3oc2c1	10.1016/j.bmcl.2013.05.062
		46206023	124603	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	267	3	1	2	3.7	COc1ccc(C)cc1-c1ccccc1C1CCNC1	nan
		CHEMBL3640609	124603	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	267	3	1	2	3.7	COc1ccc(C)cc1-c1ccccc1C1CCNC1	nan
		46206023	124603	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	267	3	1	2	3.7	COc1ccc(C)cc1-c1ccccc1C1CCNC1	nan
		CHEMBL3640609	124603	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	267	3	1	2	3.7	COc1ccc(C)cc1-c1ccccc1C1CCNC1	nan
		44461045	104730	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	403	4	0	3	4.7	Brc1ccc2ccn(CCN3CCCN(C4CCCCC4)CC3)c2c1	10.1016/s0960-894x(02)00438-9
		CHEMBL310594	104730	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	403	4	0	3	4.7	Brc1ccc2ccn(CCN3CCCN(C4CCCCC4)CC3)c2c1	10.1016/s0960-894x(02)00438-9
		76325347	106395	0	None	3	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	439	6	0	4	6.1	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3C(C)C)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
		CHEMBL3121420	106395	0	None	3	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	439	6	0	4	6.1	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3C(C)C)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
		CHEMBL3139440	106395	0	None	3	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	439	6	0	4	6.1	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3C(C)C)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
		127028797	138333	0	None	3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	494	6	2	5	3.1	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3cccc(Cl)c3Cl)CC2)C1=O	10.1016/j.ejmech.2016.02.024
		CHEMBL3771309	138333	0	None	3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	494	6	2	5	3.1	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3cccc(Cl)c3Cl)CC2)C1=O	10.1016/j.ejmech.2016.02.024
		127026444	137847	0	None	33	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	8	1	4	4.8	O=S(=O)(NC1CCN(CCOc2ccccc2C2CCCC2)CC1)c1cccc(Cl)c1	10.1016/j.ejmech.2015.11.040
		CHEMBL3760017	137847	0	None	33	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	8	1	4	4.8	O=S(=O)(NC1CCN(CCOc2ccccc2C2CCCC2)CC1)c1cccc(Cl)c1	10.1016/j.ejmech.2015.11.040
		145985224	165488	0	None	-4	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	535	6	0	7	5.0	O=S(=O)(c1cccc2ncccc12)N1CCCCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4240162	165488	0	None	-4	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	535	6	0	7	5.0	O=S(=O)(c1cccc2ncccc12)N1CCCCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
		71458623	81360	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	446	8	1	6	3.9	CSc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(Cl)s2)CC1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159308	81360	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	446	8	1	6	3.9	CSc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(Cl)s2)CC1	10.1016/j.ejmech.2012.07.043
		156021535	178184	0	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	257	2	0	2	3.8	CN(C)[C@H]1CCc2c(cccc2-c2cccs2)C1	10.1016/j.bmc.2019.115262
		CHEMBL4649289	178184	0	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	257	2	0	2	3.8	CN(C)[C@H]1CCc2c(cccc2-c2cccs2)C1	10.1016/j.bmc.2019.115262
		56945043	156405	0	None	-2	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	449	6	2	3	4.5	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(Cl)c1	10.1021/acs.jmedchem.7b00839
		CHEMBL4066532	156405	0	None	-2	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	449	6	2	3	4.5	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(Cl)c1	10.1021/acs.jmedchem.7b00839
		156013801	177282	0	None	26	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	278	1	0	2	3.5	CN(C)c1ccc2c(c1)-c1cccc3c1C(C2)N(C)CC3	10.1016/j.bmc.2020.115578
		CHEMBL4636329	177282	0	None	26	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	278	1	0	2	3.5	CN(C)c1ccc2c(c1)-c1cccc3c1C(C2)N(C)CC3	10.1016/j.bmc.2020.115578
		127051845	140729	0	None	1	9	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	309	6	0	3	3.7	COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3817898	140729	0	None	1	9	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	309	6	0	3	3.7	COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		50878551	90745	61	None	1	18	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
		CHEMBL2391541	90745	61	None	1	18	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
		73346042	91834	5	None	-173	17	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	405	9	0	8	0.9	Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O	10.1021/acs.jmedchem.2c00633
		CHEMBL2413153	91834	5	None	-173	17	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	405	9	0	8	0.9	Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O	10.1021/acs.jmedchem.2c00633
		73346042	91834	5	None	-173	17	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	405	9	0	8	0.9	Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O	10.1016/j.bmc.2013.05.050
		CHEMBL2413153	91834	5	None	-173	17	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	405	9	0	8	0.9	Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O	10.1016/j.bmc.2013.05.050
		15542627	204209	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	432	7	2	4	3.3	NC(=O)c1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
		CHEMBL70869	204209	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	432	7	2	4	3.3	NC(=O)c1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
		136152966	95593	0	None	1	5	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	289	3	2	4	2.9	COc1c(Cl)ccc2c1C(C)NC(NCC(F)F)=N2	10.1016/j.bmcl.2007.10.078
		CHEMBL257744	95593	0	None	1	5	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	289	3	2	4	2.9	COc1c(Cl)ccc2c1C(C)NC(NCC(F)F)=N2	10.1016/j.bmcl.2007.10.078
		11277147	106341	0	None	-9	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
		CHEMBL3092759	106341	0	None	-9	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
		CHEMBL3139188	106341	0	None	-9	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
		162664480	182208	0	None	26	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	441	9	0	5	5.2	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccccc3C#N)CC2)cc1	10.1016/j.ejmech.2020.112395
		CHEMBL4783043	182208	0	None	26	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	441	9	0	5	5.2	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccccc3C#N)CC2)cc1	10.1016/j.ejmech.2020.112395
		44374298	54398	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	278	5	0	4	3.8	Cc1sc(SCCN(C)C)nc1-c1ccccc1	10.1016/j.bmcl.2003.11.050
		CHEMBL160903	54398	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	278	5	0	4	3.8	Cc1sc(SCCN(C)C)nc1-c1ccccc1	10.1016/j.bmcl.2003.11.050
		145964086	164174	0	None	5	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	434	8	1	4	4.2	CC(C)c1ccccc1OCC(C)N1CCC(NS(=O)(=O)c2cccc(F)c2)CC1	10.1016/j.bmc.2017.03.057
		CHEMBL4210561	164174	0	None	5	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	434	8	1	4	4.2	CC(C)c1ccccc1OCC(C)N1CCC(NS(=O)(=O)c2cccc(F)c2)CC1	10.1016/j.bmc.2017.03.057
		44439394	145122	0	None	398	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	308	3	2	2	4.3	CSc1ccc(CC2NCCc3c2[nH]c2ccccc32)cc1	10.1016/j.bmcl.2007.01.093
		CHEMBL391191	145122	0	None	398	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	308	3	2	2	4.3	CSc1ccc(CC2NCCc3c2[nH]c2ccccc32)cc1	10.1016/j.bmcl.2007.01.093
		3377940	91779	21	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	278	2	2	2	3.4	COc1cccc(C2NCCc3c2[nH]c2ccccc32)c1	10.1016/j.bmcl.2007.01.093
		CHEMBL241098	91779	21	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	278	2	2	2	3.4	COc1cccc(C2NCCc3c2[nH]c2ccccc32)c1	10.1016/j.bmcl.2007.01.093
		136152972	95224	0	None	-7	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	293	2	2	3	3.5	C[C@H]1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.078
		CHEMBL256047	95224	0	None	-7	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	293	2	2	3	3.5	C[C@H]1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.078
		168277502	190715	0	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	468	8	0	5	6.2	S=c1n(CCCCCCN2CCN(c3cccc(Cl)c3)CC2)c2cccc3c2n1CCC3	10.1016/j.ejmech.2022.114319
		CHEMBL5182383	190715	0	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	468	8	0	5	6.2	S=c1n(CCCCCCN2CCN(c3cccc(Cl)c3)CC2)c2cccc3c2n1CCC3	10.1016/j.ejmech.2022.114319
		155533534	171884	0	None	-131	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	514	7	1	5	5.3	O=c1c(-c2ccc(F)cc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
		CHEMBL4469537	171884	0	None	-131	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	514	7	1	5	5.3	O=c1c(-c2ccc(F)cc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
		90654848	112697	0	None	1	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	484	9	0	4	4.5	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2F)CC1	10.1016/j.ejmech.2014.01.065
		CHEMBL3233673	112697	0	None	1	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	484	9	0	4	4.5	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2F)CC1	10.1016/j.ejmech.2014.01.065
		CHEMBL3304318	112697	0	None	1	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	484	9	0	4	4.5	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2F)CC1	10.1016/j.ejmech.2014.01.065
		145974184	164623	0	None	50	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	416	7	1	4	3.8	CC(C)(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccccc2)CC1	10.1021/acs.jmedchem.8b00828
		CHEMBL4216040	164623	0	None	50	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	416	7	1	4	3.8	CC(C)(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccccc2)CC1	10.1021/acs.jmedchem.8b00828
		145988913	167169	0	None	23	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	475	7	2	5	3.2	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCC(Oc3ccc(Cl)cc3)CC2)C1=O	10.1039/C8MD00168E
		CHEMBL4291141	167169	0	None	23	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	475	7	2	5	3.2	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCC(Oc3ccc(Cl)cc3)CC2)C1=O	10.1039/C8MD00168E
		18377388	205978	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	394	6	0	3	4.9	CCN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1016/s0960-894x(02)00485-7
		CHEMBL84660	205978	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	394	6	0	3	4.9	CCN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1016/s0960-894x(02)00485-7
		71602587	89680	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2013.02.038
		CHEMBL2376448	89680	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2013.02.038
		137652044	157167	0	None	2	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	464	6	0	5	3.8	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccccc3)CC2)CC1	10.1016/j.bmc.2017.04.046
		CHEMBL4075422	157167	0	None	2	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	464	6	0	5	3.8	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccccc3)CC2)CC1	10.1016/j.bmc.2017.04.046
		71727064	102408	0	None	-3	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	372	4	1	5	2.7	O=c1c2ccc(Cl)cc2oc2c(CN3CCN(CCO)CC3)cccc12	10.1016/j.bmcl.2013.05.062
		CHEMBL3039719	102408	0	None	-3	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	372	4	1	5	2.7	O=c1c2ccc(Cl)cc2oc2c(CN3CCN(CCO)CC3)cccc12	10.1016/j.bmcl.2013.05.062
		CHEMBL3216145	102408	0	None	-3	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	372	4	1	5	2.7	O=c1c2ccc(Cl)cc2oc2c(CN3CCN(CCO)CC3)cccc12	10.1016/j.bmcl.2013.05.062
		9872676	78195	0	None	-4365	16	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	565	11	2	10	4.8	COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1	10.1021/jm060012g
		CHEMBL210514	78195	0	None	-4365	16	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	565	11	2	10	4.8	COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1	10.1021/jm060012g
		71602587	89680	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2013.02.038
		CHEMBL2376448	89680	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2013.02.038
		12374770	175503	2	None	20	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	268	7	2	2	2.5	O=C(CCNCc1ccccc1)NCc1ccccc1	10.1016/j.bmcl.2016.06.080
		CHEMBL4577789	175503	2	None	20	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	268	7	2	2	2.5	O=C(CCNCc1ccccc1)NCc1ccccc1	10.1016/j.bmcl.2016.06.080
		45272864	196550	0	None	6	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	338	5	3	3	1.5	Cc1cccc(S(=O)(=O)NCCNC(=N)N2CCC(C)CC2)c1	10.1016/j.bmcl.2009.06.038
		CHEMBL563760	196550	0	None	6	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	338	5	3	3	1.5	Cc1cccc(S(=O)(=O)NCCNC(=N)N2CCC(C)CC2)c1	10.1016/j.bmcl.2009.06.038
		127029651	138221	0	None	5	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	454	6	2	5	2.4	Cc1ccc(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)cc1C	10.1016/j.ejmech.2016.02.024
		CHEMBL3770110	138221	0	None	5	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	454	6	2	5	2.4	Cc1ccc(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)cc1C	10.1016/j.ejmech.2016.02.024
		CHEMBL5080719	214702	0	None	-64	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		C[C@H]1C[C@H](NS(=O)(=O)c2cc3ccccc3o2)CN1CCCc1noc2cc(F)ccc12	10.1021/acs.jmedchem.1c00497
		155561915	176470	0	None	-109	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.2	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2C(F)(F)F)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4585051	176470	0	None	-109	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.2	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2C(F)(F)F)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4596544	176470	0	None	-109	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.2	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2C(F)(F)F)CC1	10.1016/j.bmc.2019.06.028
		71460468	81425	0	None	-5	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	403	7	1	4	4.2	CC(C)c1ccccc1OCCN1CCC(NC(=O)c2ccc3ccccc3n2)C1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159468	81425	0	None	-5	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	403	7	1	4	4.2	CC(C)c1ccccc1OCCN1CCC(NC(=O)c2ccc3ccccc3n2)C1	10.1016/j.ejmech.2012.07.043
		118729733	117934	0	None	-4	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	394	4	1	3	5.4	O=S(=O)(Nc1ccccc1-c1nccc2ccccc12)c1ccc(Cl)cc1	10.1016/j.bmcl.2015.03.049
		CHEMBL3403338	117934	0	None	-4	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	394	4	1	3	5.4	O=S(=O)(Nc1ccccc1-c1nccc2ccccc12)c1ccc(Cl)cc1	10.1016/j.bmcl.2015.03.049
		90654702	110088	0	None	-44	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	440	8	1	4	3.2	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235739	110088	0	None	-44	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	440	8	1	4	3.2	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.ejmech.2014.03.005
		164615095	184947	0	None	-13	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	414	7	0	6	2.2	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2021.128028
		CHEMBL4853700	184947	0	None	-13	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	414	7	0	6	2.2	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2021.128028
		11675876	187514	0	None	-54	3	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	407	8	0	4	3.9	COc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	10.1021/jm800615e
		CHEMBL494316	187514	0	None	-54	3	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	407	8	0	4	3.9	COc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	10.1021/jm800615e
		13069598	120615	0	None	-2	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	464	6	0	8	2.3	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		CHEMBL3360998	120615	0	None	-2	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	464	6	0	8	2.3	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		CHEMBL3546116	120615	0	None	-2	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	464	6	0	8	2.3	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		90656680	110981	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	343	6	0	3	4.0	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(Cl)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262414	110981	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	343	6	0	3	4.0	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(Cl)c1	10.1016/j.ejmech.2014.04.034
		90469114	184422	0	None	-588	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	426	3	1	6	3.5	O=S(=O)(c1cccc(Cl)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21	10.1021/acs.jmedchem.1c00224
		CHEMBL4846153	184422	0	None	-588	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	426	3	1	6	3.5	O=S(=O)(c1cccc(Cl)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21	10.1021/acs.jmedchem.1c00224
		42618258	189735	0	None	-47	2	Human	4.8	pKi	=	4.8	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	426	5	0	5	4.2	Cc1ccccc1N1CCN(CCn2c(=O)n(-c3ccccc3C)c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
		CHEMBL515789	189735	0	None	-47	2	Human	4.8	pKi	=	4.8	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	426	5	0	5	4.2	Cc1ccccc1N1CCN(CCn2c(=O)n(-c3ccccc3C)c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
		11697434	130469	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against Human 5-HT7R expressed in sf9 cellsBinding affinity against Human 5-HT7R expressed in sf9 cells	ChEMBL	419	6	0	6	3.9	COC(=O)c1cccc(C)c1-n1ccc(CN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmcl.2005.05.059
		CHEMBL368044	130469	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against Human 5-HT7R expressed in sf9 cellsBinding affinity against Human 5-HT7R expressed in sf9 cells	ChEMBL	419	6	0	6	3.9	COC(=O)c1cccc(C)c1-n1ccc(CN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmcl.2005.05.059
		10499156	114091	1	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	366	6	0	4	3.0	COc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/acs.jmedchem.2c00633
		CHEMBL332701	114091	1	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	366	6	0	4	3.0	COc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/acs.jmedchem.2c00633
		10084076	97916	0	None	1	9	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	262	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3N	10.1021/jm030030n
		CHEMBL27251	97916	0	None	1	9	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	262	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3N	10.1021/jm030030n
		68788	207607	14	None	1	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	348	3	2	3	1.3	CN1C[C@@H](NS(=O)(=O)N(C)C)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/jm030030n
		CHEMBL95067	207607	14	None	1	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	348	3	2	3	1.3	CN1C[C@@H](NS(=O)(=O)N(C)C)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/jm030030n
		134138168	147691	0	None	-1	10	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
		CHEMBL3931889	147691	0	None	-1	10	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
		76325351	106279	0	None	5	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	381	4	0	3	5.3	Cc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
		CHEMBL3121437	106279	0	None	5	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	381	4	0	3	5.3	Cc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
		CHEMBL3139023	106279	0	None	5	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	381	4	0	3	5.3	Cc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
		76336179	106398	0	None	18	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	395	4	0	3	5.6	Cc1cccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)c1C	10.1016/j.ejmech.2014.01.055
		CHEMBL3121421	106398	0	None	18	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	395	4	0	3	5.6	Cc1cccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)c1C	10.1016/j.ejmech.2014.01.055
		CHEMBL3139443	106398	0	None	18	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	395	4	0	3	5.6	Cc1cccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)c1C	10.1016/j.ejmech.2014.01.055
		137653850	159045	0	None	1	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3cccc(Cl)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
		CHEMBL4096866	159045	0	None	1	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3cccc(Cl)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
		135398737	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2016.02.024
		38	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2016.02.024
		722	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2016.02.024
		CHEMBL42	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2016.02.024
		DB00363	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2016.02.024
		90654686	110107	0	None	21	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	461	7	1	6	2.6	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235758	110107	0	None	21	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	461	7	1	6	2.6	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
		168275477	190451	0	None	263	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	388	9	5	7	3.1	Nc1nc(NCCNc2ccccc2)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
		CHEMBL5178499	190451	0	None	263	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	388	9	5	7	3.1	Nc1nc(NCCNc2ccccc2)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
		127037922	136987	0	None	2	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	508	10	0	4	5.4	O=S(=O)(c1ccc(F)cc1)N(CC1CC1)C1CCN(CCOc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2015.11.041
		CHEMBL3745853	136987	0	None	2	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	508	10	0	4	5.4	O=S(=O)(c1ccc(F)cc1)N(CC1CC1)C1CCN(CCOc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2015.11.041
		127041258	137080	0	None	2	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	434	8	0	4	4.1	CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2cccc(F)c2)CC1	10.1016/j.bmc.2015.11.041
		CHEMBL3747114	137080	0	None	2	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	434	8	0	4	4.1	CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2cccc(F)c2)CC1	10.1016/j.bmc.2015.11.041
		135398737	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.022
		38	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.022
		722	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.022
		CHEMBL42	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.022
		DB00363	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.022
		135398737	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2012.07.043
		38	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2012.07.043
		722	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2012.07.043
		CHEMBL42	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2012.07.043
		DB00363	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2012.07.043
		135398737	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.07.027
		38	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.07.027
		722	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.07.027
		CHEMBL42	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.07.027
		DB00363	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.07.027
		118731348	118185	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	10	1	4	3.9	NC(=O)[C@@H]1CCCN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
		CHEMBL3409032	118185	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	10	1	4	3.9	NC(=O)[C@@H]1CCCN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
		135398737	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2020.112437
		38	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2020.112437
		722	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2020.112437
		CHEMBL42	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2020.112437
		DB00363	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2020.112437
		135398737	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2018.01.093
		38	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2018.01.093
		722	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2018.01.093
		CHEMBL42	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2018.01.093
		DB00363	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2018.01.093
		139488740	170148	0	None	97	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	258	2	2	3	1.8	Cn1cncc1-c1c[nH]c2ccc(C(N)=O)c(F)c12	10.1016/j.ejmech.2019.03.017
		CHEMBL4444268	170148	0	None	97	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	258	2	2	3	1.8	Cn1cncc1-c1c[nH]c2ccc(C(N)=O)c(F)c12	10.1016/j.ejmech.2019.03.017
		135398737	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.01.031
		38	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.01.031
		722	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.01.031
		CHEMBL42	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.01.031
		DB00363	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.01.031
		156020374	178062	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	269	2	0	1	3.9	CN(C)C1CCc2c(cccc2-c2cccc(F)c2)C1	10.1016/j.bmc.2019.115262
		CHEMBL4647335	178062	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	269	2	0	1	3.9	CN(C)C1CCc2c(cccc2-c2cccc(F)c2)C1	10.1016/j.bmc.2019.115262
		135398737	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C8MD00168E
		38	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C8MD00168E
		722	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C8MD00168E
		CHEMBL42	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C8MD00168E
		DB00363	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C8MD00168E
		11358099	180406	0	None	-17	4	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	285	3	1	4	2.8	COc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
		CHEMBL4752099	180406	0	None	-17	4	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	285	3	1	4	2.8	COc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
		56944951	156637	0	None	-6	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	479	7	2	3	5.4	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc2ccccc12	10.1021/acs.jmedchem.7b00839
		CHEMBL4069237	156637	0	None	-6	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	479	7	2	3	5.4	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc2ccccc12	10.1021/acs.jmedchem.7b00839
		71061607	93121	0	None	48	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccncc3)CC2)cc1	10.1016/j.bmc.2014.01.016
		CHEMBL2442999	93121	0	None	48	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccncc3)CC2)cc1	10.1016/j.bmc.2014.01.016
		71061607	93121	0	None	48	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccncc3)CC2)cc1	10.1016/j.bmcl.2013.09.025
		CHEMBL2442999	93121	0	None	48	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccncc3)CC2)cc1	10.1016/j.bmcl.2013.09.025
		135398737	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.05.062
		38	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.05.062
		722	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.05.062
		CHEMBL42	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.05.062
		DB00363	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.05.062
		10084076	97916	0	None	-1	9	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	262	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3N	10.1021/jm9911433
		CHEMBL27251	97916	0	None	-1	9	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	262	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3N	10.1021/jm9911433
		10084076	97916	0	None	-1	9	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	262	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3N	10.1021/jm0108505
		CHEMBL27251	97916	0	None	-1	9	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	262	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3N	10.1021/jm0108505
		134137104	142692	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	402	6	0	4	5.0	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1C	10.1016/j.ejmech.2016.07.029
		CHEMBL3892079	142692	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	402	6	0	4	5.0	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1C	10.1016/j.ejmech.2016.07.029
		134138168	147691	0	None	-1	10	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1016/j.ejmech.2016.07.029
		CHEMBL3931889	147691	0	None	-1	10	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1016/j.ejmech.2016.07.029
		11277147	106341	0	None	-9	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3092759	106341	0	None	-9	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3139188	106341	0	None	-9	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2014.05.027
		11697434	130469	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	419	6	0	6	3.9	COC(=O)c1cccc(C)c1-n1ccc(CN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmcl.2007.03.054
		CHEMBL368044	130469	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	419	6	0	6	3.9	COC(=O)c1cccc(C)c1-n1ccc(CN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmcl.2007.03.054
		66801120	112114	0	None	-5	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	501	7	1	5	5.3	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
		CHEMBL3290007	112114	0	None	-5	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	501	7	1	5	5.3	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
		135398737	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2014.11.008
		38	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2014.11.008
		722	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2014.11.008
		CHEMBL42	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2014.11.008
		DB00363	958	93	None	-13	89	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2014.11.008
		1342	35	49	None	-13	19	Rat	7.7	pKi	=	7.7	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	10.1021/jm030826m
		3	35	49	None	-13	19	Rat	7.7	pKi	=	7.7	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	10.1021/jm030826m
		CHEMBL277120	35	49	None	-13	19	Rat	7.7	pKi	=	7.7	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	10.1021/jm030826m
		162661196	181461	0	None	-24	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	441	7	1	6	4.0	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2s1	10.1016/j.ejmech.2020.112149
		CHEMBL4764468	181461	0	None	-24	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	441	7	1	6	4.0	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2s1	10.1016/j.ejmech.2020.112149
		18663036	81820	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	268	3	1	3	2.8	COc1ccccc1-c1ccccc1N1CCNCC1	10.1021/jm3003679
		CHEMBL2164344	81820	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	268	3	1	3	2.8	COc1ccccc1-c1ccccc1N1CCNCC1	10.1021/jm3003679
		134133483	143209	0	None	5	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	614	16	1	7	5.5	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(OCCCN4CCOCC4)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		CHEMBL3896355	143209	0	None	5	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	614	16	1	7	5.5	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(OCCCN4CCOCC4)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		44266317	207943	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	349	4	0	3	4.4	O=C1CC(CN2CCC(Oc3ccccc3)CC2)CCc2ccccc21	10.1016/s0960-894x(03)00077-5
		CHEMBL9696	207943	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	349	4	0	3	4.4	O=C1CC(CN2CCC(Oc3ccccc3)CC2)CCc2ccccc21	10.1016/s0960-894x(03)00077-5
		117209858	184554	1	None	-1	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
		CHEMBL4848305	184554	1	None	-1	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
		CHEMBL5080955	214712	0	None	-2	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1ccc(F)c(Cl)c1	10.1021/acs.jmedchem.1c00497
		122196381	124295	0	None	-1	5	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	485	8	0	6	6.3	Fc1ccc2c(C3CCN(CCCOc4ccc(Cc5nc6ccccc6o5)cc4)CC3)noc2c1	10.1016/j.bmcl.2015.09.045
		CHEMBL3634821	124295	0	None	-1	5	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	485	8	0	6	6.3	Fc1ccc2c(C3CCN(CCCOc4ccc(Cc5nc6ccccc6o5)cc4)CC3)noc2c1	10.1016/j.bmcl.2015.09.045
		156017272	177652	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	287	2	0	1	4.1	CN(C)C1CCc2c(cccc2-c2cc(F)cc(F)c2)C1	10.1016/j.bmc.2019.115262
		CHEMBL4641478	177652	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	287	2	0	1	4.1	CN(C)C1CCc2c(cccc2-c2cc(F)cc(F)c2)C1	10.1016/j.bmc.2019.115262
		156019520	177999	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	257	2	0	2	3.8	CN(C)[C@@H]1CCc2c(cccc2-c2cccs2)C1	10.1016/j.bmc.2019.115262
		CHEMBL4646359	177999	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	257	2	0	2	3.8	CN(C)[C@@H]1CCc2c(cccc2-c2cccs2)C1	10.1016/j.bmc.2019.115262
		66800959	157438	0	None	-8	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	413	6	2	3	3.7	Cc1cccc(S(=O)(=O)NCCN2CC=C(c3c[nH]c4ccc(F)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
		CHEMBL4078873	157438	0	None	-8	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	413	6	2	3	3.7	Cc1cccc(S(=O)(=O)NCCN2CC=C(c3c[nH]c4ccc(F)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
		118706296	120525	0	None	-5	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	308	2	3	2	1.3	CC(=O)NC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
		CHEMBL3310119	120525	0	None	-5	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	308	2	3	2	1.3	CC(=O)NC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
		CHEMBL3545441	120525	0	None	-5	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	308	2	3	2	1.3	CC(=O)NC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
		71151588	118258	0	None	-1778	10	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cells	ChEMBL	518	9	1	7	3.6	NC(=O)c1ccccc1OCCCN1CCN(c2cccc3c2ccn3S(=O)(=O)c2ccccc2)CC1	10.1016/j.ejmech.2014.12.045
		CHEMBL3409256	118258	0	None	-1778	10	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cells	ChEMBL	518	9	1	7	3.6	NC(=O)c1ccccc1OCCCN1CCN(c2cccc3c2ccn3S(=O)(=O)c2ccccc2)CC1	10.1016/j.ejmech.2014.12.045
		66801333	112088	0	None	1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	470	8	1	7	3.9	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
		CHEMBL3289982	112088	0	None	1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	470	8	1	7	3.9	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
		46205702	124596	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	257	2	1	1	4.1	Clc1ccc(-c2ccccc2C2CCNC2)cc1	nan
		CHEMBL3640602	124596	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	257	2	1	1	4.1	Clc1ccc(-c2ccccc2C2CCNC2)cc1	nan
		46205702	124596	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	257	2	1	1	4.1	Clc1ccc(-c2ccccc2C2CCNC2)cc1	nan
		CHEMBL3640602	124596	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	257	2	1	1	4.1	Clc1ccc(-c2ccccc2C2CCNC2)cc1	nan
		CHEMBL5287809	194396	0	None	-218	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis	ChEMBL	615	10	0	8	5.0	O=C1CC2Cc3ccsc3C2=NN1CCCCCN1CCN(Cc2cccc3c2ccn3S(=O)(=O)c2ccccc2)CC1	10.1016/j.bmc.2023.117256
		2948971	73211	9	None	-25	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	397	2	3	1	5.6	O=C1Nc2ccc(Cl)cc2C1(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12	10.1016/j.bmcl.2015.03.049
		CHEMBL2011865	73211	9	None	-25	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	397	2	3	1	5.6	O=C1Nc2ccc(Cl)cc2C1(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12	10.1016/j.bmcl.2015.03.049
		134131265	142186	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	424	8	0	5	5.0	Cc1nc(OCCCCCN2CCN(c3ccc(Cl)cc3)CC2)c2ccccc2n1	10.1016/j.bmc.2016.12.039
		CHEMBL3883995	142186	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	424	8	0	5	5.0	Cc1nc(OCCCCCN2CCN(c3ccc(Cl)cc3)CC2)c2ccccc2n1	10.1016/j.bmc.2016.12.039
		44324602	207429	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	293	3	2	3	4.2	Cc1c(NC2=NCCN2)cccc1-c1cccc(C(C)C)c1	10.1016/s0960-894x(02)00925-3
		CHEMBL94056	207429	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	293	3	2	3	4.2	Cc1c(NC2=NCCN2)cccc1-c1cccc(C(C)C)c1	10.1016/s0960-894x(02)00925-3
		44460744	205723	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	363	6	0	4	3.9	CN1CCCN(CCn2ccc3ccc(OCc4ccccc4)cc32)CC1	10.1016/s0960-894x(02)00438-9
		CHEMBL82550	205723	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	363	6	0	4	3.9	CN1CCCN(CCn2ccc3ccc(OCc4ccccc4)cc32)CC1	10.1016/s0960-894x(02)00438-9
		44424669	85724	0	None	-1	2	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	412	6	1	8	0.3	Cn1c(=O)c2c([nH]c(=O)n2CCCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2007.05.017
		CHEMBL228939	85724	0	None	-1	2	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	412	6	1	8	0.3	Cn1c(=O)c2c([nH]c(=O)n2CCCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2007.05.017
		168291393	191994	0	None	-4	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	338	8	2	3	2.7	NC(=O)NCCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2022.114319
		CHEMBL5201464	191994	0	None	-4	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	338	8	2	3	2.7	NC(=O)NCCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2022.114319
		155515408	176332	0	None	-8	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	491	8	0	3	5.9	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Br)cc2)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4442062	176332	0	None	-8	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	491	8	0	3	5.9	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Br)cc2)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4595453	176332	0	None	-8	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	491	8	0	3	5.9	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Br)cc2)CC1	10.1016/j.bmc.2019.06.028
		23369450	181572	2	None	-72	2	Human	5.7	pKi	=	5.7	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	352	5	1	5	2.2	COc1ccccc1N1CCN(CCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
		CHEMBL476822	181572	2	None	-72	2	Human	5.7	pKi	=	5.7	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	352	5	1	5	2.2	COc1ccccc1N1CCN(CCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
		53377140	66405	0	None	-5	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	6	0	6	4.2	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2011.04.060
		CHEMBL1851835	66405	0	None	-5	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	6	0	6	4.2	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2011.04.060
		CHEMBL3216729	66405	0	None	-5	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	6	0	6	4.2	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2011.04.060
		155515890	170002	0	None	-5	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	414	8	0	4	4.6	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2019.06.029
		CHEMBL4442385	170002	0	None	-5	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	414	8	0	4	4.6	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2019.06.029
		11667626	102584	0	None	-11	2	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	359	10	1	4	2.4	CCc1ccccc1OCCNCCCCN1C(=O)C2CCCN2C1=O	10.1021/jm400766k
		CHEMBL2431042	102584	0	None	-11	2	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	359	10	1	4	2.4	CCc1ccccc1OCCNCCCCN1C(=O)C2CCCN2C1=O	10.1021/jm400766k
		CHEMBL3040827	102584	0	None	-11	2	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	359	10	1	4	2.4	CCc1ccccc1OCCNCCCCN1C(=O)C2CCCN2C1=O	10.1021/jm400766k
		135398745	2914	112	None	-95	65	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.ejmech.2012.07.043
		47	2914	112	None	-95	65	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.ejmech.2012.07.043
		CHEMBL715	2914	112	None	-95	65	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.ejmech.2012.07.043
		DB00334	2914	112	None	-95	65	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.ejmech.2012.07.043
		118728512	117707	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	423	8	1	4	5.3	Cc1sc2nc(CCCCCN3CCC(Cc4ccccc4)CC3)[nH]c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
		CHEMBL3401475	117707	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	423	8	1	4	5.3	Cc1sc2nc(CCCCCN3CCC(Cc4ccccc4)CC3)[nH]c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
		23151734	103958	0	None	-467	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	265	1	2	2	1.3	NC(N)=NC(=O)c1ccc2c(c1)C(=O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
		CHEMBL3092758	103958	0	None	-467	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	265	1	2	2	1.3	NC(N)=NC(=O)c1ccc2c(c1)C(=O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
		71602586	89679	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)cc1OC	10.1016/j.bmc.2013.02.038
		CHEMBL2376447	89679	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)cc1OC	10.1016/j.bmc.2013.02.038
		168281784	190947	0	None	-30	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	429	8	0	6	4.0	O=c1n(CCCCCCN2CCN(c3cccc4ccccc34)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
		CHEMBL5185787	190947	0	None	-30	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	429	8	0	6	4.0	O=c1n(CCCCCCN2CCN(c3cccc4ccccc34)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
		11432215	84299	0	None	1	2	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	8	1	5	3.8	COc1ccc2c(c1)CCCC2NC(=O)CCCN1CCN(c2ccccc2OC)CC1	10.1021/jm049702f
		CHEMBL221453	84299	0	None	1	2	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	8	1	5	3.8	COc1ccc2c(c1)CCCC2NC(=O)CCCN1CCN(c2ccccc2OC)CC1	10.1021/jm049702f
		164619236	185709	0	None	-9	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	366	6	1	5	2.6	O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
		CHEMBL4865591	185709	0	None	-9	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	366	6	1	5	2.6	O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
		72549767	114072	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	429	8	1	4	4.2	COc1ccccc1N1CCN(CCC(=O)NCc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2014.07.026
		CHEMBL3326976	114072	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	429	8	1	4	4.2	COc1ccccc1N1CCN(CCC(=O)NCc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2014.07.026
		71602586	89679	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)cc1OC	10.1016/j.bmc.2013.02.038
		CHEMBL2376447	89679	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)cc1OC	10.1016/j.bmc.2013.02.038
		90654696	110082	0	None	-35	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	374	7	2	5	1.2	NC(=O)[C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2O)CC1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235733	110082	0	None	-35	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	374	7	2	5	1.2	NC(=O)[C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2O)CC1	10.1016/j.ejmech.2014.03.005
		42618257	181596	0	None	-11	2	Human	5.7	pKi	=	5.7	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	412	5	0	5	3.9	Cc1ccccc1N1CCN(CCn2c(=O)n(-c3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
		CHEMBL477066	181596	0	None	-11	2	Human	5.7	pKi	=	5.7	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	412	5	0	5	3.9	Cc1ccccc1N1CCN(CCn2c(=O)n(-c3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
		57400830	68437	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	429	8	0	4	4.5	CCN(CCCCN1CCC2CCCCC2C1)S(=O)(=O)c1cnc2ccccc2c1	10.1016/j.bmc.2011.09.044
		CHEMBL1917358	68437	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	429	8	0	4	4.5	CCN(CCCCN1CCC2CCCCC2C1)S(=O)(=O)c1cnc2ccccc2c1	10.1016/j.bmc.2011.09.044
		164619236	185709	0	None	-9	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	366	6	1	5	2.6	O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
		CHEMBL4865591	185709	0	None	-9	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	366	6	1	5	2.6	O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
		162676036	183785	0	None	-22	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	410	9	2	5	2.7	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccccc2C(N)=O)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4798934	183785	0	None	-22	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	410	9	2	5	2.7	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccccc2C(N)=O)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4804093	183785	0	None	-22	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	410	9	2	5	2.7	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccccc2C(N)=O)CC1	10.1016/j.ejmech.2020.112437
		228	445	28	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm9911433
		33	445	28	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm9911433
		6005	445	28	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm9911433
		CHEMBL53	445	28	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm9911433
		DB00714	445	28	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm9911433
		156015087	177540	0	None	1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	406	7	1	4	4.8	C=CCOc1c(OC)cc2c3c1-c1cc(NC(=O)CCC)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
		CHEMBL4640150	177540	0	None	1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	406	7	1	4	4.8	C=CCOc1c(OC)cc2c3c1-c1cc(NC(=O)CCC)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
		228	445	28	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm0108505
		33	445	28	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm0108505
		6005	445	28	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm0108505
		CHEMBL53	445	28	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm0108505
		DB00714	445	28	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm0108505
		228	445	28	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/s0960-894x(00)00655-7
		33	445	28	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/s0960-894x(00)00655-7
		6005	445	28	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/s0960-894x(00)00655-7
		CHEMBL53	445	28	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/s0960-894x(00)00655-7
		DB00714	445	28	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/s0960-894x(00)00655-7
		44424668	144373	0	None	-1	2	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	432	5	1	8	0.6	Cn1c(=O)c2c([nH]c(=O)n2CCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2007.05.017
		CHEMBL390581	144373	0	None	-1	2	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	432	5	1	8	0.6	Cn1c(=O)c2c([nH]c(=O)n2CCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2007.05.017
		76336182	105508	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	368	4	0	4	4.3	c1ccc(N2CCN(Cc3cn(-c4ccccn4)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
		CHEMBL3121430	105508	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	368	4	0	4	4.3	c1ccc(N2CCN(Cc3cn(-c4ccccn4)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
		127051016	140876	0	None	-6	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	386	5	1	4	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
		CHEMBL3819642	140876	0	None	-6	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	386	5	1	4	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
		CHEMBL3819734	140876	0	None	-6	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	386	5	1	4	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
		46205046	124581	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	273	3	1	2	3.7	Cc1cccc(-c2ccc(Cl)cc2OC2CNC2)c1	nan
		CHEMBL3640587	124581	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	273	3	1	2	3.7	Cc1cccc(-c2ccc(Cl)cc2OC2CNC2)c1	nan
		46205046	124581	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	273	3	1	2	3.7	Cc1cccc(-c2ccc(Cl)cc2OC2CNC2)c1	nan
		CHEMBL3640587	124581	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	273	3	1	2	3.7	Cc1cccc(-c2ccc(Cl)cc2OC2CNC2)c1	nan
		46203755	124546	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2cccc(F)c2C)cc1OC1CNC1	nan
		CHEMBL3640554	124546	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2cccc(F)c2C)cc1OC1CNC1	nan
		46205371	124585	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	285	3	1	2	3.9	COc1ccc(-c2cccc(F)c2C)cc1C1CCNC1	nan
		CHEMBL3640591	124585	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	285	3	1	2	3.9	COc1ccc(-c2cccc(F)c2C)cc1C1CCNC1	nan
		11617668	64696	0	None	-3	3	Rat	7.7	pKi	=	7.7	Binding	Binding affinity against rat 5-HT7R expressed in HEK293 cellsBinding affinity against rat 5-HT7R expressed in HEK293 cells	ChEMBL	372	5	0	5	3.7	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C#N)c2)CC1	10.1016/j.bmcl.2005.05.059
		CHEMBL181874	64696	0	None	-3	3	Rat	7.7	pKi	=	7.7	Binding	Binding affinity against rat 5-HT7R expressed in HEK293 cellsBinding affinity against rat 5-HT7R expressed in HEK293 cells	ChEMBL	372	5	0	5	3.7	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C#N)c2)CC1	10.1016/j.bmcl.2005.05.059
		4806	4008	88	None	-8	13	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human 5-HT7R assessed as inhibition constantBinding affinity to human 5-HT7R assessed as inhibition constant	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2021.128275
		7351	4008	88	None	-8	13	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human 5-HT7R assessed as inhibition constantBinding affinity to human 5-HT7R assessed as inhibition constant	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2021.128275
		9966051	4008	88	None	-8	13	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human 5-HT7R assessed as inhibition constantBinding affinity to human 5-HT7R assessed as inhibition constant	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2021.128275
		CHEMBL2104993	4008	88	None	-8	13	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human 5-HT7R assessed as inhibition constantBinding affinity to human 5-HT7R assessed as inhibition constant	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2021.128275
		DB09068	4008	88	None	-8	13	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human 5-HT7R assessed as inhibition constantBinding affinity to human 5-HT7R assessed as inhibition constant	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2021.128275
		4806	4008	88	None	-8	13	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
		7351	4008	88	None	-8	13	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
		9966051	4008	88	None	-8	13	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
		CHEMBL2104993	4008	88	None	-8	13	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
		DB09068	4008	88	None	-8	13	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
		11384575	66174	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	418	9	0	5	3.2	CCN(CCCN1CCc2cc(OC)ccc2C1)S(=O)(=O)c1ccc(OC)cc1	10.1021/jm049743b
		CHEMBL184310	66174	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	418	9	0	5	3.2	CCN(CCCN1CCc2cc(OC)ccc2C1)S(=O)(=O)c1ccc(OC)cc1	10.1021/jm049743b
		11373831	124649	0	None	-1	2	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	431	9	0	5	3.2	CCN(CCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1ccc(C)cc1	10.1021/jm049743b
		CHEMBL364124	124649	0	None	-1	2	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	431	9	0	5	3.2	CCN(CCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1ccc(C)cc1	10.1021/jm049743b
		46203755	124546	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2cccc(F)c2C)cc1OC1CNC1	nan
		CHEMBL3640554	124546	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2cccc(F)c2C)cc1OC1CNC1	nan
		46205371	124585	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	285	3	1	2	3.9	COc1ccc(-c2cccc(F)c2C)cc1C1CCNC1	nan
		CHEMBL3640591	124585	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	285	3	1	2	3.9	COc1ccc(-c2cccc(F)c2C)cc1C1CCNC1	nan
		11373831	124649	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	431	9	0	5	3.2	CCN(CCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1ccc(C)cc1	10.1016/j.bmc.2011.09.044
		CHEMBL364124	124649	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	431	9	0	5	3.2	CCN(CCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1ccc(C)cc1	10.1016/j.bmc.2011.09.044
		127026750	137677	0	None	14	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	446	8	1	4	4.3	O=S(=O)(NC1CCN(CCOc2ccccc2C2CCCC2)CC1)c1cccc(F)c1	10.1016/j.ejmech.2015.11.040
		CHEMBL3758591	137677	0	None	14	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	446	8	1	4	4.3	O=S(=O)(NC1CCN(CCOc2ccccc2C2CCCC2)CC1)c1cccc(F)c1	10.1016/j.ejmech.2015.11.040
		118626089	165473	3	None	-2	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4239823	165473	3	None	-2	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
		118626035	165518	0	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4240954	165518	0	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
		145983760	165540	0	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	534	6	0	6	5.6	O=S(=O)(c1cccc2ncccc12)N1CCCCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4241497	165540	0	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	534	6	0	6	5.6	O=S(=O)(c1cccc2ncccc12)N1CCCCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
		145983390	165919	0	None	-6	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	535	6	0	7	5.0	O=S(=O)(c1ccnc2ccccc12)N1CCCCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4250274	165919	0	None	-6	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	535	6	0	7	5.0	O=S(=O)(c1ccnc2ccccc12)N1CCCCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
		134156305	154249	0	None	7	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	510	11	1	5	5.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@@H](C)c3ccc(C#N)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		CHEMBL3986254	154249	0	None	7	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	510	11	1	5	5.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@@H](C)c3ccc(C#N)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		145993714	167352	0	None	21	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	483	6	2	6	2.7	CC1(c2cccc3ccccc23)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1039/C8MD00168E
		CHEMBL4294549	167352	0	None	21	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	483	6	2	6	2.7	CC1(c2cccc3ccccc23)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1039/C8MD00168E
		127037681	136614	0	None	7	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	406	8	1	6	2.4	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cnn(C)c2)CC1	10.1039/C5MD00166H
		CHEMBL3739745	136614	0	None	7	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	406	8	1	6	2.4	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cnn(C)c2)CC1	10.1039/C5MD00166H
		127041106	136782	0	None	16	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	440	8	1	6	2.9	Cn1cc(S(=O)(=O)NC2CCN(CCOc3ccccc3-c3ccccc3)CC2)cn1	10.1039/C5MD00166H
		CHEMBL3741281	136782	0	None	16	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	440	8	1	6	2.9	Cn1cc(S(=O)(=O)NC2CCN(CCOc3ccccc3-c3ccccc3)CC2)cn1	10.1039/C5MD00166H
		117209858	184554	1	None	-1	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
		CHEMBL4848305	184554	1	None	-1	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
		66800934	112054	0	None	-8	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	514	9	1	7	4.1	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
		CHEMBL3289949	112054	0	None	-8	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	514	9	1	7	4.1	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
		118626089	165473	3	None	-2	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from recombinant human 5-HT7R after 120 mins by scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7R after 120 mins by scintillation counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4239823	165473	3	None	-2	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from recombinant human 5-HT7R after 120 mins by scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7R after 120 mins by scintillation counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
		11101733	102832	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	413	5	1	3	4.9	Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
		CHEMBL305526	102832	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	413	5	1	3	4.9	Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
		10896196	204261	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	484	7	1	4	4.5	CN(C)C(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
		CHEMBL71170	204261	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	484	7	1	4	4.5	CN(C)C(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
		155555378	174434	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	432	7	1	5	4.7	O=c1[nH]c(CCCCCN2CCN(c3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
		CHEMBL4553199	174434	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	432	7	1	5	4.7	O=c1[nH]c(CCCCCN2CCN(c3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
		10948529	54159	0	None	54	2	Rat	7.7	pKi	=	7.7	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	365	6	1	6	3.3	O=C(CCCN1CCN(c2noc3ccccc23)CC1)c1ccccc1O	10.1021/jm020994z
		CHEMBL160706	54159	0	None	54	2	Rat	7.7	pKi	=	7.7	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	365	6	1	6	3.3	O=C(CCCN1CCN(c2noc3ccccc23)CC1)c1ccccc1O	10.1021/jm020994z
		46205375	124589	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	337	4	1	3	4.3	COc1ccc(-c2ccccc2OC(F)(F)F)cc1C1CCNC1	nan
		CHEMBL3640595	124589	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	337	4	1	3	4.3	COc1ccc(-c2ccccc2OC(F)(F)F)cc1C1CCNC1	nan
		46205375	124589	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	337	4	1	3	4.3	COc1ccc(-c2ccccc2OC(F)(F)F)cc1C1CCNC1	nan
		CHEMBL3640595	124589	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	337	4	1	3	4.3	COc1ccc(-c2ccccc2OC(F)(F)F)cc1C1CCNC1	nan
		162675490	183129	0	None	-2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	503	8	2	7	3.6	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccc4c(c3)NC(=O)C(C)O4)CC2)cc1	10.1016/j.ejmech.2020.112395
		CHEMBL4795056	183129	0	None	-2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	503	8	2	7	3.6	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccc4c(c3)NC(=O)C(C)O4)CC2)cc1	10.1016/j.ejmech.2020.112395
		2470	3653	50	None	-389	59	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/s0960-894x(00)00166-9
		3300	3653	50	None	-389	59	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/s0960-894x(00)00166-9
		5265	3653	50	None	-389	59	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/s0960-894x(00)00166-9
		99	3653	50	None	-389	59	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/s0960-894x(00)00166-9
		CHEMBL267930	3653	50	None	-389	59	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/s0960-894x(00)00166-9
		10552788	18671	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	480	6	0	3	4.3	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2ccc(Br)c(Br)c2)CC1	10.1021/jm970519e
		CHEMBL12771	18671	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	480	6	0	3	4.3	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2ccc(Br)c(Br)c2)CC1	10.1021/jm970519e
		10552788	18671	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	480	6	0	3	4.3	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2ccc(Br)c(Br)c2)CC1	10.1016/s0960-894x(00)00166-9
		CHEMBL12771	18671	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	480	6	0	3	4.3	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2ccc(Br)c(Br)c2)CC1	10.1016/s0960-894x(00)00166-9
		44368304	44906	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	479	6	0	3	5.1	CC1CCN(CC[C@@H](C)C(C)S(=O)(=O)c2ccc(Br)c(Br)c2)CC1	10.1021/jm030841r
		CHEMBL152292	44906	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	479	6	0	3	5.1	CC1CCN(CC[C@@H](C)C(C)S(=O)(=O)c2ccc(Br)c(Br)c2)CC1	10.1021/jm030841r
		134138168	147691	0	None	-1	10	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
		CHEMBL3931889	147691	0	None	-1	10	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
		CHEMBL5094493	215499	0	None	1	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCN(CCC)CCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		153287541	172195	0	None	10	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	279	1	0	2	3.9	CN1CC[C@H]2c3cccc(-c4ccccc4)c3OC[C@]21C	10.1021/acsmedchemlett.9b00225
		CHEMBL4473697	172195	0	None	10	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	279	1	0	2	3.9	CN1CC[C@H]2c3cccc(-c4ccccc4)c3OC[C@]21C	10.1021/acsmedchemlett.9b00225
		135398737	958	93	None	-13	89	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
		38	958	93	None	-13	89	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
		722	958	93	None	-13	89	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
		CHEMBL42	958	93	None	-13	89	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
		DB00363	958	93	None	-13	89	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
		24865725	188084	0	None	-39	12	Human	7.7	pKi	=	7.7	Binding	Displacement of radioligand from human cloned 5HT7 receptorDisplacement of radioligand from human cloned 5HT7 receptor	ChEMBL	453	8	1	5	4.2	Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1	10.1021/jm8001444
		CHEMBL497963	188084	0	None	-39	12	Human	7.7	pKi	=	7.7	Binding	Displacement of radioligand from human cloned 5HT7 receptorDisplacement of radioligand from human cloned 5HT7 receptor	ChEMBL	453	8	1	5	4.2	Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1	10.1021/jm8001444
		2470	3653	50	None	-1258	59	Human	7.7	pKi	=	7.7	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030841r
		3300	3653	50	None	-1258	59	Human	7.7	pKi	=	7.7	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030841r
		5265	3653	50	None	-1258	59	Human	7.7	pKi	=	7.7	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030841r
		99	3653	50	None	-1258	59	Human	7.7	pKi	=	7.7	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030841r
		CHEMBL267930	3653	50	None	-1258	59	Human	7.7	pKi	=	7.7	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030841r
		162668859	183742	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	9	1	4	5.3	COc1ccccc1N1CCN(CCCCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4788452	183742	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	9	1	4	5.3	COc1ccccc1N1CCN(CCCCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4803670	183742	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	9	1	4	5.3	COc1ccccc1N1CCN(CCCCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
		156020807	178048	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	307	6	0	1	5.3	CCCN(CCC)[C@@H]1CCc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2019.115262
		CHEMBL4647184	178048	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	307	6	0	1	5.3	CCCN(CCC)[C@@H]1CCc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2019.115262
		127051016	140876	0	None	-6	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	386	5	1	4	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
		CHEMBL3819642	140876	0	None	-6	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	386	5	1	4	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
		CHEMBL3819734	140876	0	None	-6	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	386	5	1	4	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
		6918542	204924	24	None	-537	10	Human	5.7	pKi	=	5.7	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	358	6	0	5	3.0	COc1ccc2c(c1)c(CCN(C)C)cn2S(=O)(=O)c1ccccc1	10.1021/jm010943m
		CHEMBL76237	204924	24	None	-537	10	Human	5.7	pKi	=	5.7	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	358	6	0	5	3.0	COc1ccc2c(c1)c(CCN(C)C)cn2S(=O)(=O)c1ccccc1	10.1021/jm010943m
		122483296	138105	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	363	6	0	4	4.2	CN1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3764934	138105	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	363	6	0	4	4.2	CN1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3765870	138105	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	363	6	0	4	4.2	CN1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		164623281	185812	0	None	-1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	447	7	0	5	3.5	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2021.128028
		CHEMBL4867109	185812	0	None	-1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	447	7	0	5	3.5	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2021.128028
		90656704	112685	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	381	10	1	4	4.6	CCN(CCCCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262435	112685	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	381	10	1	4	4.6	CCN(CCCCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3304198	112685	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	381	10	1	4	4.6	CCN(CCCCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		122483296	138105	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	363	6	0	4	4.2	CN1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3764934	138105	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	363	6	0	4	4.2	CN1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3765870	138105	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	363	6	0	4	4.2	CN1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		71450247	82976	0	None	-380	8	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	368	5	0	3	5.5	CCCN1CCC(COc2nc3c(Cl)cccc3c3ccccc23)CC1	10.1021/jm300943r
		CHEMBL2181188	82976	0	None	-380	8	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	368	5	0	3	5.5	CCCN1CCC(COc2nc3c(Cl)cccc3c3ccccc23)CC1	10.1021/jm300943r
		127026434	137740	0	None	3	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	9	1	4	4.9	CC(C)c1cccc(C(C)C)c1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
		CHEMBL3759170	137740	0	None	3	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	9	1	4	4.9	CC(C)c1cccc(C(C)C)c1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
		76314437	105506	0	None	25	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	443	5	0	3	6.6	c1ccc(-c2ccc(-n3cc(CN4CCN(c5ccccc5)CC4)c4ccccc43)cc2)cc1	10.1016/j.ejmech.2014.01.055
		CHEMBL3121418	105506	0	None	25	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	443	5	0	3	6.6	c1ccc(-c2ccc(-n3cc(CN4CCN(c5ccccc5)CC4)c4ccccc43)cc2)cc1	10.1016/j.ejmech.2014.01.055
		155534362	171904	0	None	-91	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	522	8	1	6	5.3	COc1ccc(-c2c(=O)n(CCCCN3CCCC(c4c[nH]c5ccccc45)C3)c(=O)n3ccccc23)cc1	10.1016/j.ejmech.2019.01.031
		CHEMBL4469813	171904	0	None	-91	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	522	8	1	6	5.3	COc1ccc(-c2c(=O)n(CCCCN3CCCC(c4c[nH]c5ccccc45)C3)c(=O)n3ccccc23)cc1	10.1016/j.ejmech.2019.01.031
		168287508	191531	0	None	-48	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	438	9	3	8	3.1	Nc1nc(N)nc(NCCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n1	10.1016/j.ejmech.2021.113931
		CHEMBL5194270	191531	0	None	-48	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	438	9	3	8	3.1	Nc1nc(N)nc(NCCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n1	10.1016/j.ejmech.2021.113931
		156020306	178129	0	None	-4	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	602	11	0	6	6.9	O=S(=O)(c1ccccc1)N(CCCCCCN1CCN(c2nsc3ccccc23)CC1)c1cccc(C(F)(F)F)c1	10.1016/j.bmc.2020.115459
		CHEMBL4648390	178129	0	None	-4	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	602	11	0	6	6.9	O=S(=O)(c1ccccc1)N(CCCCCCN1CCN(c2nsc3ccccc23)CC1)c1cccc(C(F)(F)F)c1	10.1016/j.bmc.2020.115459
		42625267	186807	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	348	6	0	2	4.2	O=C1Cc2ccccc2N1CCCCN1CCCC(c2ccccc2)C1	10.1021/jm8014553
		CHEMBL489255	186807	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	348	6	0	2	4.2	O=C1Cc2ccccc2N1CCCCN1CCCC(c2ccccc2)C1	10.1021/jm8014553
		73213196	104460	4	None	-1	13	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
		CHEMBL3104093	104460	4	None	-1	13	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
		164622318	185836	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	6	1	7	2.5	CN1CCN(c2nc(N)nc(CCCOc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.ejmech.2020.112529
		CHEMBL4867534	185836	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	6	1	7	2.5	CN1CCN(c2nc(N)nc(CCCOc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.ejmech.2020.112529
		71455625	82964	0	None	-48977	5	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	353	5	0	4	4.4	CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1	10.1021/jm300943r
		CHEMBL2181170	82964	0	None	-48977	5	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	353	5	0	4	4.4	CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1	10.1021/jm300943r
		73213196	104460	4	None	-1	13	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2014.05.016
		CHEMBL3104093	104460	4	None	-1	13	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2014.05.016
		44517732	195231	0	None	50	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	481	8	3	5	2.9	COc1ccccc1N1CCN(C(=N)NCCCNS(=O)(=O)c2cccc3ccccc23)CC1	10.1016/j.bmcl.2009.06.038
		CHEMBL550881	195231	0	None	50	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	481	8	3	5	2.9	COc1ccccc1N1CCN(C(=N)NCCCNS(=O)(=O)c2cccc3ccccc23)CC1	10.1016/j.bmcl.2009.06.038
		71727065	102409	0	None	-8	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	430	5	0	6	4.3	COc1ccc2c(=O)c3cccc(CN4CCN(c5ccccc5OC)CC4)c3oc2c1	10.1016/j.bmcl.2013.05.062
		CHEMBL2401931	102409	0	None	-8	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	430	5	0	6	4.3	COc1ccc2c(=O)c3cccc(CN4CCN(c5ccccc5OC)CC4)c3oc2c1	10.1016/j.bmcl.2013.05.062
		CHEMBL3039720	102409	0	None	-8	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	430	5	0	6	4.3	COc1ccc2c(=O)c3cccc(CN4CCN(c5ccccc5OC)CC4)c3oc2c1	10.1016/j.bmcl.2013.05.062
		73213196	104460	4	None	-1	13	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
		CHEMBL3104093	104460	4	None	-1	13	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
		51002362	82622	0	None	-3	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	448	5	1	7	3.8	COc1ccc(S(=O)(=O)n2cc(C)c3cc(Cl)cnc32)cc1NC1CCN(C)CC1	10.1021/jm300955x
		CHEMBL2179222	82622	0	None	-3	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	448	5	1	7	3.8	COc1ccc(S(=O)(=O)n2cc(C)c3cc(Cl)cnc32)cc1NC1CCN(C)CC1	10.1021/jm300955x
		168273001	190212	0	None	3	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	403	9	4	7	3.3	COc1ccccc1CCNc1nc(N)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
		CHEMBL5174637	190212	0	None	3	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	403	9	4	7	3.3	COc1ccccc1CCNc1nc(N)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
		72197845	89844	0	None	-25	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	486	7	2	3	5.3	O=C1CC(c2c[nH]c3ccccc23)C(=O)N1CCCCN1CCC(c2c[nH]c3ccc(F)cc23)CC1	10.1016/j.ejmech.2019.111736
		CHEMBL2377590	89844	0	None	-25	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	486	7	2	3	5.3	O=C1CC(c2c[nH]c3ccccc23)C(=O)N1CCCCN1CCC(c2c[nH]c3ccc(F)cc23)CC1	10.1016/j.ejmech.2019.111736
		72197845	89844	0	None	-25	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	486	7	2	3	5.3	O=C1CC(c2c[nH]c3ccccc23)C(=O)N1CCCCN1CCC(c2c[nH]c3ccc(F)cc23)CC1	10.1016/j.ejmech.2013.02.033
		CHEMBL2377590	89844	0	None	-25	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	486	7	2	3	5.3	O=C1CC(c2c[nH]c3ccccc23)C(=O)N1CCCCN1CCC(c2c[nH]c3ccc(F)cc23)CC1	10.1016/j.ejmech.2013.02.033
		127026143	137797	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	434	7	1	3	5.3	O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc(Cl)c1	10.1016/j.ejmech.2015.11.040
		CHEMBL3759593	137797	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	434	7	1	3	5.3	O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc(Cl)c1	10.1016/j.ejmech.2015.11.040
		155540198	172903	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	406	7	0	4	3.3	O=C(CCCCN1CCN(c2ccccc2)CC1)N1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2016.06.080
		CHEMBL4516076	172903	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	406	7	0	4	3.3	O=C(CCCCN1CCN(c2ccccc2)CC1)N1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2016.06.080
		4790508	8175	4	None	-24	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	333	7	2	5	2.0	OC(CNCC1COc2ccccc2O1)COc1ccccc1F	10.1016/j.bmcl.2010.03.012
		CHEMBL1091933	8175	4	None	-24	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	333	7	2	5	2.0	OC(CNCC1COc2ccccc2O1)COc1ccccc1F	10.1016/j.bmcl.2010.03.012
		44424658	85763	0	None	-2	2	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	440	8	0	9	1.4	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2007.05.017
		CHEMBL229180	85763	0	None	-2	2	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	440	8	0	9	1.4	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2007.05.017
		23290944	81826	0	None	-131	7	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay	ChEMBL	392	6	0	4	3.8	O=C(C1CCCCC1)N(CCN1CCN(c2ccccc2)CC1)c1ccccn1	10.1016/j.bmcl.2012.05.119
		CHEMBL2164350	81826	0	None	-131	7	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay	ChEMBL	392	6	0	4	3.8	O=C(C1CCCCC1)N(CCN1CCN(c2ccccc2)CC1)c1ccccn1	10.1016/j.bmcl.2012.05.119
		45269494	196666	0	None	10	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	436	7	3	3	3.5	N=C(NCCCCNS(=O)(=O)c1cccc2ccccc12)N1CCc2ccccc2C1	10.1016/j.bmcl.2009.06.038
		CHEMBL564509	196666	0	None	10	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	436	7	3	3	3.5	N=C(NCCCCNS(=O)(=O)c1cccc2ccccc12)N1CCc2ccccc2C1	10.1016/j.bmcl.2009.06.038
		127026146	137774	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	449	7	2	3	5.7	O=C(Nc1cccc(Cl)c1)NC1CCN(CCOc2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2015.11.040
		CHEMBL3759437	137774	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	449	7	2	3	5.7	O=C(Nc1cccc(Cl)c1)NC1CCN(CCOc2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2015.11.040
		156018383	177923	0	None	-16	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	443	8	0	4	4.1	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmc.2020.115459
		CHEMBL4645308	177923	0	None	-16	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	443	8	0	4	4.1	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmc.2020.115459
		53381002	65465	0	None	-22	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation counting	ChEMBL	240	2	2	4	2.2	COc1cccc2[nH]cc(-c3ccnc(N)n3)c12	10.1016/j.bmc.2011.08.033
		CHEMBL1829959	65465	0	None	-22	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation counting	ChEMBL	240	2	2	4	2.2	COc1cccc2[nH]cc(-c3ccnc(N)n3)c12	10.1016/j.bmc.2011.08.033
		164620867	185642	0	None	-177	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	410	6	1	7	3.4	CCCC(Oc1cc(Cl)cc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
		CHEMBL4864448	185642	0	None	-177	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	410	6	1	7	3.4	CCCC(Oc1cc(Cl)cc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
		156018897	177812	0	None	-8	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	356	4	1	3	3.6	CCCN1CCc2cccc3c2C1Cc1ccc(NS(C)(=O)=O)cc1-3	10.1016/j.bmc.2020.115578
		CHEMBL4643640	177812	0	None	-8	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	356	4	1	3	3.6	CCCN1CCc2cccc3c2C1Cc1ccc(NS(C)(=O)=O)cc1-3	10.1016/j.bmc.2020.115578
		11397459	19357	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	479	9	0	5	4.7	COc1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/s0960-894x(00)00166-9
		CHEMBL12908	19357	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	479	9	0	5	4.7	COc1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/s0960-894x(00)00166-9
		11259115	19404	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	435	7	0	4	4.3	O=S1(=O)c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/s0960-894x(00)00166-9
		CHEMBL12933	19404	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	435	7	0	4	4.3	O=S1(=O)c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/s0960-894x(00)00166-9
		11453756	19988	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	451	7	0	5	4.0	COc1ccccc1N1CCN(CCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/s0960-894x(00)00166-9
		CHEMBL13032	19988	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	451	7	0	5	4.0	COc1ccccc1N1CCN(CCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/s0960-894x(00)00166-9
		11382534	98105	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	350	6	0	2	4.9	CC(C)C1CCN(CCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1016/s0960-894x(00)00166-9
		CHEMBL273452	98105	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	350	6	0	2	4.9	CC(C)C1CCN(CCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1016/s0960-894x(00)00166-9
		49850567	56469	0	None	-999	9	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	452	6	1	6	4.0	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5cnccn5)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1632217	56469	0	None	-999	9	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	452	6	1	6	4.0	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5cnccn5)c4)CC3)cccc2n1	10.1021/jm100714c
		11397459	19357	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	479	9	0	5	4.7	COc1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1021/jm030841r
		CHEMBL12908	19357	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	479	9	0	5	4.7	COc1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1021/jm030841r
		11259115	19404	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	435	7	0	4	4.3	O=S1(=O)c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1021/jm030841r
		CHEMBL12933	19404	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	435	7	0	4	4.3	O=S1(=O)c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1021/jm030841r
		11453756	19988	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	451	7	0	5	4.0	COc1ccccc1N1CCN(CCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1021/jm030841r
		CHEMBL13032	19988	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	451	7	0	5	4.0	COc1ccccc1N1CCN(CCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1021/jm030841r
		11382534	98105	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	350	6	0	2	4.9	CC(C)C1CCN(CCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1021/jm030841r
		CHEMBL273452	98105	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	350	6	0	2	4.9	CC(C)C1CCN(CCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1021/jm030841r
		71602690	89687	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2013.02.038
		CHEMBL2376459	89687	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2013.02.038
		153287567	172384	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	292	1	1	2	4.3	Cc1ccc(N2C[C@@]3(C)NCC[C@H]3c3cc(C)ccc32)cc1	10.1021/acsmedchemlett.9b00225
		CHEMBL4476396	172384	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	292	1	1	2	4.3	Cc1ccc(N2C[C@@]3(C)NCC[C@H]3c3cc(C)ccc32)cc1	10.1021/acsmedchemlett.9b00225
		155557042	174557	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	219	1	1	3	1.9	COc1ccc2c(c1)[C@@H]1CCN[C@]1(C)CO2	10.1021/acsmedchemlett.9b00225
		CHEMBL4556297	174557	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	219	1	1	3	1.9	COc1ccc2c(c1)[C@@H]1CCN[C@]1(C)CO2	10.1021/acsmedchemlett.9b00225
		153287557	176079	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	420	1	1	2	5.2	C[C@@]12CN(c3ccc(Br)cc3)c3ccc(Br)cc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
		CHEMBL4591108	176079	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	420	1	1	2	5.2	C[C@@]12CN(c3ccc(Br)cc3)c3ccc(Br)cc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
		10296414	3531	15	None	-158	9	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	10.1016/j.bmcl.2006.11.031
		76	3531	15	None	-158	9	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	10.1016/j.bmcl.2006.11.031
		CHEMBL183460	3531	15	None	-158	9	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	10.1016/j.bmcl.2006.11.031
		73213195	104459	0	None	-7	12	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
		CHEMBL3104092	104459	0	None	-7	12	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
		164610456	184500	0	None	-61	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	328	5	1	7	1.7	CCC(Oc1ccccc1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
		CHEMBL4847379	184500	0	None	-61	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	328	5	1	7	1.7	CCC(Oc1ccccc1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
		9891618	107124	0	None	-1995	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligand	ChEMBL	486	4	1	6	5.0	Cc1c(S(=O)(=O)Nc2ccc3nccc(N4CCN(C)CC4)c3c2)sc2ccc(Cl)cc12	10.1016/s0960-894x(01)00558-3
		CHEMBL316081	107124	0	None	-1995	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligand	ChEMBL	486	4	1	6	5.0	Cc1c(S(=O)(=O)Nc2ccc3nccc(N4CCN(C)CC4)c3c2)sc2ccc(Cl)cc12	10.1016/s0960-894x(01)00558-3
		44393088	65013	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	386	8	3	7	3.4	CC(Nc1nc(N)nc(NCCOc2ccc(F)cc2)n1)c1ccc(F)cc1	10.1016/j.ejmech.2019.111705
		CHEMBL182322	65013	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	386	8	3	7	3.4	CC(Nc1nc(N)nc(NCCOc2ccc(F)cc2)n1)c1ccc(F)cc1	10.1016/j.ejmech.2019.111705
		44393113	63631	0	None	5	3	Human	8.7	pKi	=	8.7	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	358	7	3	7	3.5	CC(Nc1nc(N)nc(NCCc2cccs2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
		CHEMBL180086	63631	0	None	5	3	Human	8.7	pKi	=	8.7	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	358	7	3	7	3.5	CC(Nc1nc(N)nc(NCCc2cccs2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
		10475231	65387	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	386	8	3	7	3.4	C[C@H](Nc1nc(N)nc(NCCOc2ccc(F)cc2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
		CHEMBL182937	65387	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	386	8	3	7	3.4	C[C@H](Nc1nc(N)nc(NCCOc2ccc(F)cc2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
		44393161	66696	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	334	8	2	5	4.1	C[C@H](Nc1ccnc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		CHEMBL185511	66696	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	334	8	2	5	4.1	C[C@H](Nc1ccnc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		44393045	161659	0	None	9	3	Human	8.7	pKi	=	8.7	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	370	7	3	6	3.6	C[C@H](Nc1nc(N)nc(NCCc2ccc(F)cc2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
		CHEMBL413049	161659	0	None	9	3	Human	8.7	pKi	=	8.7	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	370	7	3	6	3.6	C[C@H](Nc1nc(N)nc(NCCc2ccc(F)cc2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
		107	141	121	None	-3	30	Human	8.7	pKi	=	8.7	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1021/jm030030n
		1833	141	121	None	-3	30	Human	8.7	pKi	=	8.7	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1021/jm030030n
		CHEMBL8165	141	121	None	-3	30	Human	8.7	pKi	=	8.7	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1021/jm030030n
		145970078	164811	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay	ChEMBL	485	7	1	3	5.3	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(Cc2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.7b01898
		CHEMBL4218549	164811	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay	ChEMBL	485	7	1	3	5.3	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(Cc2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.7b01898
		8431	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm030030n
		9843179	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm030030n
		CHEMBL69257	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm030030n
		10028436	3532	5	None	-1	12	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1021/jm030030n
		3237	3532	5	None	-1	12	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1021/jm030030n
		CHEMBL95104	3532	5	None	-1	12	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1021/jm030030n
		1621	2429	17	None	-34	45	Rat	8.7	pKi	=	8.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm030030n
		17	2429	17	None	-34	45	Rat	8.7	pKi	=	8.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm030030n
		5761	2429	17	None	-34	45	Rat	8.7	pKi	=	8.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm030030n
		CHEMBL263881	2429	17	None	-34	45	Rat	8.7	pKi	=	8.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm030030n
		DB04829	2429	17	None	-34	45	Rat	8.7	pKi	=	8.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm030030n
		127025242	137802	0	None	70	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	446	8	1	4	4.3	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2cccc(F)c2)C3)c1	10.1016/j.ejmech.2015.11.040
		CHEMBL3759617	137802	0	None	70	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	446	8	1	4	4.3	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2cccc(F)c2)C3)c1	10.1016/j.ejmech.2015.11.040
		71455002	81446	0	None	7	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	440	8	1	4	3.9	O=S(=O)(N[C@@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159489	81446	0	None	7	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	440	8	1	4	3.9	O=S(=O)(N[C@@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
		155534839	171998	0	None	4	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	437	6	1	3	5.9	Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccsc2)c1	10.1016/j.bmcl.2019.126703
		CHEMBL4471208	171998	0	None	4	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	437	6	1	3	5.9	Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccsc2)c1	10.1016/j.bmcl.2019.126703
		56944954	157566	0	None	1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	445	7	3	4	4.0	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(O)c1	10.1021/acs.jmedchem.7b00839
		CHEMBL4080399	157566	0	None	1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	445	7	3	4	4.0	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(O)c1	10.1021/acs.jmedchem.7b00839
		56944956	158919	0	None	-1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	433	6	2	3	4.0	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(F)c1	10.1021/acs.jmedchem.7b00839
		CHEMBL4095555	158919	0	None	-1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	433	6	2	3	4.0	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(F)c1	10.1021/acs.jmedchem.7b00839
		10834268	166826	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	390	6	1	4	3.6	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3	10.1016/j.bmc.2019.06.028
		CHEMBL428494	166826	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	390	6	1	4	3.6	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3	10.1016/j.bmc.2019.06.028
		10028436	3532	5	None	-1	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting method	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/j.bmcl.2018.06.019
		3237	3532	5	None	-1	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting method	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/j.bmcl.2018.06.019
		CHEMBL95104	3532	5	None	-1	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting method	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/j.bmcl.2018.06.019
		66800909	112070	0	None	4	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	473	7	1	8	3.4	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
		CHEMBL3289965	112070	0	None	4	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	473	7	1	8	3.4	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
		10274894	165190	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	438	6	1	2	6.0	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(F)cc2)CC1)CCC3	10.1016/s0960-894x(02)00842-9
		CHEMBL422869	165190	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	438	6	1	2	6.0	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(F)cc2)CC1)CCC3	10.1016/s0960-894x(02)00842-9
		44266182	207324	0	None	23	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	407	4	0	5	3.3	O=C1c2ccccc2CCCN1CCN1CCC(n2nnc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
		CHEMBL9347	207324	0	None	23	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	407	4	0	5	3.3	O=C1c2ccccc2CCCN1CCN1CCC(n2nnc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
		24854368	159818	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	377	7	1	3	4.3	CCC1(CCCCN2CCN(c3ccccc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		CHEMBL410628	159818	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	377	7	1	3	4.3	CCC1(CCCCN2CCN(c3ccccc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		8431	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/s0960-894x(02)00438-9
		9843179	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/s0960-894x(02)00438-9
		CHEMBL69257	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/s0960-894x(02)00438-9
		5	139	72	None	-3	54	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00726
		5202	139	72	None	-3	54	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00726
		CHEMBL39	139	72	None	-3	54	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00726
		DB08839	139	72	None	-3	54	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00726
		11633354	95980	0	None	52	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm200547z
		CHEMBL259550	95980	0	None	52	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm200547z
		11633354	95980	0	None	52	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm070279v
		CHEMBL259550	95980	0	None	52	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm070279v
		5	139	72	None	-3	54	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2016.06.080
		5202	139	72	None	-3	54	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2016.06.080
		CHEMBL39	139	72	None	-3	54	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2016.06.080
		DB08839	139	72	None	-3	54	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2016.06.080
		439280	120019	107	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1016/j.bmcl.2015.02.042
		6971044	120019	107	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1016/j.bmcl.2015.02.042
		CHEMBL350221	120019	107	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1016/j.bmcl.2015.02.042
		8431	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.ejmech.2019.111705
		9843179	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.ejmech.2019.111705
		CHEMBL69257	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.ejmech.2019.111705
		8431	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/s0960-894x(02)00842-9
		9843179	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/s0960-894x(02)00842-9
		CHEMBL69257	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/s0960-894x(02)00842-9
		10500557	16680	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	389	6	1	3	4.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3	10.1016/j.bmcl.2009.12.027
		CHEMBL12427	16680	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	389	6	1	3	4.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3	10.1016/j.bmcl.2009.12.027
		8431	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm0104264
		9843179	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm0104264
		CHEMBL69257	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm0104264
		8431	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm980519u
		9843179	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm980519u
		CHEMBL69257	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm980519u
		8431	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.bmc.2011.12.039
		9843179	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.bmc.2011.12.039
		CHEMBL69257	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.bmc.2011.12.039
		44276598	95683	0	None	1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	386	6	1	2	5.2	O=C1Nc2cccc3c2[C@]1(CCCCN1CC=C(c2ccccc2)CC1)CCC3	10.1016/j.bmcl.2010.03.012
		CHEMBL25815	95683	0	None	1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	386	6	1	2	5.2	O=C1Nc2cccc3c2[C@]1(CCCCN1CC=C(c2ccccc2)CC1)CCC3	10.1016/j.bmcl.2010.03.012
		9845006	18239	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm070279v
		CHEMBL12702	18239	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm070279v
		8431	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/acs.jmedchem.7b01898
		9843179	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/acs.jmedchem.7b01898
		CHEMBL69257	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/acs.jmedchem.7b01898
		8431	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting method	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.bmcl.2018.06.019
		9843179	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting method	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.bmcl.2018.06.019
		CHEMBL69257	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting method	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.bmcl.2018.06.019
		8431	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.ejmech.2014.08.023
		9843179	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.ejmech.2014.08.023
		CHEMBL69257	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.ejmech.2014.08.023
		141745657	172377	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	394	5	1	4	4.7	Fc1ccc2[nH]cc(CCCN3CCN(c4nsc5ccccc45)CC3)c2c1	10.1016/j.bmcl.2019.126703
		CHEMBL4476294	172377	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	394	5	1	4	4.7	Fc1ccc2[nH]cc(CCCN3CCN(c4nsc5ccccc45)CC3)c2c1	10.1016/j.bmcl.2019.126703
		4106	2502	22	None	-4	34	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmc.2019.07.046
		5358812	2502	22	None	-4	34	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmc.2019.07.046
		89	2502	22	None	-4	34	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmc.2019.07.046
		CHEMBL93240	2502	22	None	-4	34	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmc.2019.07.046
		44437327	90867	0	None	-	1	Rat	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	650	15	0	8	5.9	COc1ccccc1N1CCN(CCc2cccc(OCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		CHEMBL239231	90867	0	None	-	1	Rat	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	650	15	0	8	5.9	COc1ccccc1N1CCN(CCc2cccc(OCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		9888494	98171	0	None	1	13	Human	8.7	pKi	=	8.7	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	422	4	1	5	3.6	O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
		CHEMBL273921	98171	0	None	1	13	Human	8.7	pKi	=	8.7	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	422	4	1	5	3.6	O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
		9888494	98171	0	None	-1	13	Rat	8.7	pKi	=	8.7	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	422	4	1	5	3.6	O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3cc(F)ccc32)CC1	10.1021/jm0498102
		CHEMBL273921	98171	0	None	-1	13	Rat	8.7	pKi	=	8.7	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	422	4	1	5	3.6	O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3cc(F)ccc32)CC1	10.1021/jm0498102
		118706734	120526	0	None	-3	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	309	2	3	2	1.9	CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
		CHEMBL3310714	120526	0	None	-3	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	309	2	3	2	1.9	CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
		CHEMBL3545444	120526	0	None	-3	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	309	2	3	2	1.9	CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
		145993474	167317	0	None	10	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	417	5	1	2	5.5	Fc1ccc2[nH]cc(CCN3CCN(c4ccccc4-c4ccccc4F)CC3)c2c1	10.1016/j.ejmech.2017.12.063
		CHEMBL4294077	167317	0	None	10	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	417	5	1	2	5.5	Fc1ccc2[nH]cc(CCN3CCN(c4ccccc4-c4ccccc4F)CC3)c2c1	10.1016/j.ejmech.2017.12.063
		10862697	204385	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	419	7	1	4	4.2	COc1cccc(N2CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC2)c1	10.1021/jm0104264
		CHEMBL71847	204385	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	419	7	1	4	4.2	COc1cccc(N2CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC2)c1	10.1021/jm0104264
		44327688	112664	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	375	5	1	3	3.4	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/s0960-894x(02)00690-x
		CHEMBL330353	112664	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	375	5	1	3	3.4	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/s0960-894x(02)00690-x
		44327688	112664	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	375	5	1	3	3.4	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1	10.1021/jm030030n
		CHEMBL330353	112664	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	375	5	1	3	3.4	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1	10.1021/jm030030n
		16006605	97992	3	None	2	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	229	0	2	3	2.6	CC1NC(N)=Nc2c(Cl)ccc(Cl)c21	10.1016/j.bmcl.2007.10.080
		CHEMBL272781	97992	3	None	2	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	229	0	2	3	2.6	CC1NC(N)=Nc2c(Cl)ccc(Cl)c21	10.1016/j.bmcl.2007.10.080
		135966709	155155	4	None	10	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	233	2	2	4	2.3	CNC1=Nc2c(OC(C)C)cccc2C(C)N1	10.1016/j.bmcl.2007.10.080
		CHEMBL402179	155155	4	None	10	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	233	2	2	4	2.3	CNC1=Nc2c(OC(C)C)cccc2C(C)N1	10.1016/j.bmcl.2007.10.080
		24825775	1523	14	None	346	2	Human	8.6	pKi	=	8.6	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1016/j.ejmech.2019.111705
		3929	1523	14	None	346	2	Human	8.6	pKi	=	8.6	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1016/j.ejmech.2019.111705
		CHEMBL4205349	1523	14	None	346	2	Human	8.6	pKi	=	8.6	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1016/j.ejmech.2019.111705
		24825775	1523	14	None	346	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.7b01898
		3929	1523	14	None	346	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.7b01898
		CHEMBL4205349	1523	14	None	346	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.7b01898
		4376990	193009	5	None	1	11	Human	8.6	pKi	=	8.6	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
		CHEMBL5207529	193009	5	None	1	11	Human	8.6	pKi	=	8.6	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
		CHEMBL5222754	193009	5	None	1	11	Human	8.6	pKi	=	8.6	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
		24825775	1523	14	None	346	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human 5-HT7 receptor expressed in HEK293F cells assessed as inhibition constant by HTRF assayBinding affinity to human 5-HT7 receptor expressed in HEK293F cells assessed as inhibition constant by HTRF assay	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.2c00633
		3929	1523	14	None	346	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human 5-HT7 receptor expressed in HEK293F cells assessed as inhibition constant by HTRF assayBinding affinity to human 5-HT7 receptor expressed in HEK293F cells assessed as inhibition constant by HTRF assay	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.2c00633
		CHEMBL4205349	1523	14	None	346	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human 5-HT7 receptor expressed in HEK293F cells assessed as inhibition constant by HTRF assayBinding affinity to human 5-HT7 receptor expressed in HEK293F cells assessed as inhibition constant by HTRF assay	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.2c00633
		CHEMBL5074190	214314	0	None	29	9	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(CCN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
		24825775	1523	14	None	346	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1039/C8MD00313K
		3929	1523	14	None	346	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1039/C8MD00313K
		CHEMBL4205349	1523	14	None	346	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1039/C8MD00313K
		16093485	155063	0	None	1	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	239	1	2	4	2.3	COc1cc(Cl)c(C)c2c1N=C(N)NC2C	10.1016/j.bmcl.2007.10.080
		CHEMBL401745	155063	0	None	1	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	239	1	2	4	2.3	COc1cc(Cl)c(C)c2c1N=C(N)NC2C	10.1016/j.bmcl.2007.10.080
		44266315	98385	0	None	30	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	410	5	0	3	4.3	O=C(c1ccc(Cl)cc1)C1CCN(CCN2CCCc3ccccc3C2=O)CC1	10.1016/s0960-894x(03)00077-5
		CHEMBL275343	98385	0	None	30	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	410	5	0	3	4.3	O=C(c1ccc(Cl)cc1)C1CCN(CCN2CCCc3ccccc3C2=O)CC1	10.1016/s0960-894x(03)00077-5
		CHEMBL5074190	214314	0	None	29	9	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(CCN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
		11153905	65606	0	None	2	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	313	4	0	4	3.2	COc1cccc(OC)c1-c1cccc2c1OC[C@H](N(C)C)C2	10.1016/j.bmc.2010.01.035
		CHEMBL183329	65606	0	None	2	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	313	4	0	4	3.2	COc1cccc(OC)c1-c1cccc2c1OC[C@H](N(C)C)C2	10.1016/j.bmc.2010.01.035
		24854369	96200	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	407	8	1	4	4.3	CCC1(CCCCN2CCN(c3cccc(OC)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		CHEMBL260762	96200	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	407	8	1	4	4.3	CCC1(CCCCN2CCN(c3cccc(OC)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		10064052	124269	0	None	93	5	Rat	8.6	pKi	=	8.6	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	311	4	0	3	3.8	COc1cccc(OC)c1-c1cccc2c1CC[C@H](N(C)C)C2	10.1021/jm0498102
		CHEMBL363466	124269	0	None	93	5	Rat	8.6	pKi	=	8.6	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	311	4	0	3	3.8	COc1cccc(OC)c1-c1cccc2c1CC[C@H](N(C)C)C2	10.1021/jm0498102
		10064052	124269	0	None	93	5	Rat	8.6	pKi	=	8.6	Binding	Inhibition of [3H]5-HT binding to rat 5-HT7 receptorInhibition of [3H]5-HT binding to rat 5-HT7 receptor	ChEMBL	311	4	0	3	3.8	COc1cccc(OC)c1-c1cccc2c1CC[C@H](N(C)C)C2	10.1021/jm0498102
		CHEMBL363466	124269	0	None	93	5	Rat	8.6	pKi	=	8.6	Binding	Inhibition of [3H]5-HT binding to rat 5-HT7 receptorInhibition of [3H]5-HT binding to rat 5-HT7 receptor	ChEMBL	311	4	0	3	3.8	COc1cccc(OC)c1-c1cccc2c1CC[C@H](N(C)C)C2	10.1021/jm0498102
		22001618	81813	10	None	1	3	Human	8.6	pKi	=	8.6	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	268	3	1	3	2.8	COc1ccc(-c2ccccc2N2CCNCC2)cc1	10.1016/j.ejmech.2019.111705
		CHEMBL2164336	81813	10	None	1	3	Human	8.6	pKi	=	8.6	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	268	3	1	3	2.8	COc1ccc(-c2ccccc2N2CCNCC2)cc1	10.1016/j.ejmech.2019.111705
		22001618	81813	10	None	-1	3	Rat	8.6	pKi	=	8.6	Binding	Binding affinity to 5-HT7 in rat brainBinding affinity to 5-HT7 in rat brain	ChEMBL	268	3	1	3	2.8	COc1ccc(-c2ccccc2N2CCNCC2)cc1	10.1016/j.bmc.2013.06.020
		CHEMBL2164336	81813	10	None	-1	3	Rat	8.6	pKi	=	8.6	Binding	Binding affinity to 5-HT7 in rat brainBinding affinity to 5-HT7 in rat brain	ChEMBL	268	3	1	3	2.8	COc1ccc(-c2ccccc2N2CCNCC2)cc1	10.1016/j.bmc.2013.06.020
		11545363	190498	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human recombinant 5-HT7 receptor assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor assessed as inhibition constant	ChEMBL	379	7	1	4	3.7	COc1cccc(N2CCN(CCCCC3C(=O)Nc4ccccc43)CC2)c1	10.1021/acs.jmedchem.2c00633
		CHEMBL5179267	190498	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human recombinant 5-HT7 receptor assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor assessed as inhibition constant	ChEMBL	379	7	1	4	3.7	COc1cccc(N2CCN(CCCCC3C(=O)Nc4ccccc43)CC2)c1	10.1021/acs.jmedchem.2c00633
		168269899	190077	0	None	2	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	461	8	0	5	3.6	COc1ccccc1N1CCN(CCC[C@H]2CCCN2S(=O)(=O)c2ccc(F)cc2)CC1	10.1021/acs.jmedchem.2c00633
		CHEMBL5172635	190077	0	None	2	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	461	8	0	5	3.6	COc1ccccc1N1CCN(CCC[C@H]2CCCN2S(=O)(=O)c2ccc(F)cc2)CC1	10.1021/acs.jmedchem.2c00633
		22001618	81813	10	None	1	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	268	3	1	3	2.8	COc1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
		CHEMBL2164336	81813	10	None	1	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	268	3	1	3	2.8	COc1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
		66801018	112092	0	None	2	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	502	8	1	7	4.4	Cc1c(S(=O)(=O)NCCCCN2CCN(c3noc4ccccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
		CHEMBL3289986	112092	0	None	2	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	502	8	1	7	4.4	Cc1c(S(=O)(=O)NCCCCN2CCN(c3noc4ccccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
		145991864	167005	0	None	5	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	449	6	1	2	6.0	Fc1cccc(-c2ccc(F)cc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.ejmech.2017.12.063
		CHEMBL4288120	167005	0	None	5	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	449	6	1	2	6.0	Fc1cccc(-c2ccc(F)cc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.ejmech.2017.12.063
		153287566	171180	0	None	74	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	278	1	0	2	4.0	CN1CC[C@H]2c3ccccc3N(c3ccccc3)C[C@]21C	10.1021/acsmedchemlett.9b00225
		CHEMBL4459009	171180	0	None	74	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	278	1	0	2	4.0	CN1CC[C@H]2c3ccccc3N(c3ccccc3)C[C@]21C	10.1021/acsmedchemlett.9b00225
		23133427	81809	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	256	2	1	2	2.9	Fc1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
		CHEMBL2164332	81809	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	256	2	1	2	2.9	Fc1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
		118709756	113547	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	352	6	0	2	4.4	O=C1Cc2ccccc2N1CC/C=C/CCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
		CHEMBL3321798	113547	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	352	6	0	2	4.4	O=C1Cc2ccccc2N1CC/C=C/CCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
		11772153	66873	0	None	3	3	Rat	8.6	pKi	=	8.6	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	339	7	0	3	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2ccccc2OC)C1	10.1021/jm0498102
		CHEMBL186316	66873	0	None	3	3	Rat	8.6	pKi	=	8.6	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	339	7	0	3	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2ccccc2OC)C1	10.1021/jm0498102
		44437335	151657	0	None	-	1	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	722	16	0	11	5.0	COc1ccccc1N1CCN(CCc2cccc(OC(=O)COCC(=O)Oc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		CHEMBL396396	151657	0	None	-	1	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	722	16	0	11	5.0	COc1ccccc1N1CCN(CCc2cccc(OC(=O)COCC(=O)Oc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		44266222	208370	0	None	7	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	387	4	0	3	4.4	O=C1c2ccccc2CCCN1CCN1CCC(n2ccc3ccccc32)CC1	10.1016/s0960-894x(03)00077-5
		CHEMBL9952	208370	0	None	7	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	387	4	0	3	4.4	O=C1c2ccccc2CCCN1CCN1CCC(n2ccc3ccccc32)CC1	10.1016/s0960-894x(03)00077-5
		CHEMBL5077293	214491	0	None	1	9	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCNC2)ccc1Cl	10.1021/acs.jmedchem.1c00110
		162666034	182311	0	None	1	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	419	7	1	5	3.5	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc(Cl)c1	10.1016/j.ejmech.2020.112149
		CHEMBL4784228	182311	0	None	1	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	419	7	1	5	3.5	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc(Cl)c1	10.1016/j.ejmech.2020.112149
		CHEMBL5077293	214491	0	None	1	9	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCNC2)ccc1Cl	10.1021/acs.jmedchem.1c00110
		CHEMBL5094234	215573	0	None	2	8	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		CHEMBL5096019	215573	0	None	2	8	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		11697659	95855	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm200547z
		CHEMBL259010	95855	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm200547z
		11697659	95855	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm070279v
		CHEMBL259010	95855	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm070279v
		CHEMBL5091373	215567	0	None	1	9	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		CHEMBL5095981	215567	0	None	1	9	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		118713593	114379	0	None	26	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	338	5	0	4	3.9	O=c1sc2ccccc2n1CCCCN1CCc2ccccc2C1	10.1016/j.ejmech.2014.08.023
		CHEMBL3331262	114379	0	None	26	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	338	5	0	4	3.9	O=c1sc2ccccc2n1CCCCN1CCc2ccccc2C1	10.1016/j.ejmech.2014.08.023
		90656683	110975	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	375	6	1	4	4.2	CN(CCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262408	110975	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	375	6	1	4	4.2	CN(CCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		118713684	114389	0	None	-6	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	425	9	0	6	4.5	COc1ccccc1N1CCN(CCCCCCn2c(=O)sc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
		CHEMBL3331387	114389	0	None	-6	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	425	9	0	6	4.5	COc1ccccc1N1CCN(CCCCCCn2c(=O)sc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
		11186985	123846	0	None	-11	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	307	6	0	1	5.3	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2010.01.035
		CHEMBL362540	123846	0	None	-11	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	307	6	0	1	5.3	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2010.01.035
		11267988	66829	0	None	-2	4	Rat	8.5	pKi	=	8.5	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	309	6	0	2	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2ccccc2)C1	10.1021/jm0498102
		CHEMBL186112	66829	0	None	-2	4	Rat	8.5	pKi	=	8.5	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	309	6	0	2	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2ccccc2)C1	10.1021/jm0498102
		10430685	54299	0	None	64	5	Rat	8.5	pKi	=	8.5	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	393	8	1	6	4.1	O=C(CCCCCN1CCN(c2noc3ccccc23)CC1)c1ccccc1O	10.1021/jm020994z
		CHEMBL160817	54299	0	None	64	5	Rat	8.5	pKi	=	8.5	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	393	8	1	6	4.1	O=C(CCCCCN1CCN(c2noc3ccccc23)CC1)c1ccccc1O	10.1021/jm020994z
		118713682	114387	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	395	8	0	5	4.4	O=c1sc2ccccc2n1CCCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
		CHEMBL3331385	114387	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	395	8	0	5	4.4	O=c1sc2ccccc2n1CCCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
		118728530	117726	0	None	-2	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	454	9	0	7	4.5	CCOc1ccccc1N1CCN(CCCCCn2cnc3sc(C)c(C)c3c2=O)CC1	10.1016/j.bmcl.2015.02.042
		CHEMBL3401493	117726	0	None	-2	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	454	9	0	7	4.5	CCOc1ccccc1N1CCN(CCCCCn2cnc3sc(C)c(C)c3c2=O)CC1	10.1016/j.bmcl.2015.02.042
		42388639	188054	0	None	-4	6	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	439	8	1	5	3.3	COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2009.06.038
		CHEMBL497749	188054	0	None	-4	6	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	439	8	1	5	3.3	COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2009.06.038
		90656685	110974	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay	ChEMBL	325	6	1	4	3.0	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262407	110974	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay	ChEMBL	325	6	1	4	3.0	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		2470	3653	50	None	-389	59	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
		3300	3653	50	None	-389	59	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
		5265	3653	50	None	-389	59	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
		99	3653	50	None	-389	59	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
		CHEMBL267930	3653	50	None	-389	59	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
		CHEMBL5094493	215499	0	None	1	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCN(CCC)CCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		76336181	106399	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	433	4	1	4	5.8	Oc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
		CHEMBL3121425	106399	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	433	4	1	4	5.8	Oc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
		CHEMBL3139444	106399	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	433	4	1	4	5.8	Oc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
		76318013	106400	0	None	4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	435	4	0	3	6.0	FC(F)(F)c1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
		CHEMBL3121427	106400	0	None	4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	435	4	0	3	6.0	FC(F)(F)c1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
		CHEMBL3139445	106400	0	None	4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	435	4	0	3	6.0	FC(F)(F)c1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
		127026452	137673	0	None	3	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	498	8	1	4	5.0	O=S(=O)(NC1CC2CCC(C1)N2CCOc1cccc(-c2ccccc2)c1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2015.11.040
		CHEMBL3758569	137673	0	None	3	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	498	8	1	4	5.0	O=S(=O)(NC1CC2CCC(C1)N2CCOc1cccc(-c2ccccc2)c1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2015.11.040
		127024949	137796	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	442	8	1	4	4.0	O=S(=O)(NC1CN(CCOc2ccccc2-c2ccccc2)C1)c1cccc(Cl)c1	10.1016/j.ejmech.2015.11.040
		CHEMBL3759581	137796	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	442	8	1	4	4.0	O=S(=O)(NC1CN(CCOc2ccccc2-c2ccccc2)C1)c1cccc(Cl)c1	10.1016/j.ejmech.2015.11.040
		71454997	81411	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	490	9	1	5	5.1	O=S(=O)(NCC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159455	81411	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	490	9	1	5	5.1	O=S(=O)(NCC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
		145947405	167671	0	None	5	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	472	7	2	6	2.3	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(Cl)cc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
		CHEMBL4159967	167671	0	None	5	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	472	7	2	6	2.3	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(Cl)cc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
		CHEMBL4301968	167671	0	None	5	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	472	7	2	6	2.3	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(Cl)cc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
		138691316	174688	0	None	61	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	289	2	1	2	3.8	CCn1cncc1-c1c[nH]c2ccc(Br)cc12	10.1016/j.ejmech.2019.03.017
		CHEMBL4559312	174688	0	None	61	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	289	2	1	2	3.8	CCn1cncc1-c1c[nH]c2ccc(Br)cc12	10.1016/j.ejmech.2019.03.017
		59752638	182397	0	None	-1	4	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	253	2	1	3	2.6	c1ccc(-c2c3c(nn2C2CC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
		CHEMBL4785470	182397	0	None	-1	4	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	253	2	1	3	2.6	c1ccc(-c2c3c(nn2C2CC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
		11732538	204301	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	419	7	1	4	4.2	COc1ccc(N2CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC2)cc1	10.1016/j.bmc.2019.06.028
		CHEMBL71390	204301	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	419	7	1	4	4.2	COc1ccc(N2CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC2)cc1	10.1016/j.bmc.2019.06.028
		90656685	110974	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	325	6	1	4	3.0	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262407	110974	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	325	6	1	4	3.0	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		118713595	114381	0	None	4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	381	7	0	5	4.1	O=c1sc2ccccc2n1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
		CHEMBL3331264	114381	0	None	4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	381	7	0	5	4.1	O=c1sc2ccccc2n1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
		44439392	91782	0	None	4677	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	336	5	2	2	5.1	CCCSc1ccccc1CC1NCCc2c1[nH]c1ccccc21	10.1016/j.bmcl.2007.01.093
		CHEMBL241100	91782	0	None	4677	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	336	5	2	2	5.1	CCCSc1ccccc1CC1NCCc2c1[nH]c1ccccc21	10.1016/j.bmcl.2007.01.093
		66801613	112050	0	None	-2	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	484	7	1	6	4.1	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
		CHEMBL3289945	112050	0	None	-2	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	484	7	1	6	4.1	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
		122178709	121375	0	None	2	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	381	6	0	5	4.0	C=CCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
		CHEMBL3581254	121375	0	None	2	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	381	6	0	5	4.0	C=CCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
		16573	177619	34	None	8	6	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	341	3	1	5	3.2	COc1cc2c(cc1O)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
		CHEMBL464099	177619	34	None	8	6	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	341	3	1	5	3.2	COc1cc2c(cc1O)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
		11341035	144342	0	None	1	2	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	465	10	1	5	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3c(OC)cccc32)CC1	10.1021/jm049702f
		CHEMBL390558	144342	0	None	1	2	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	465	10	1	5	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3c(OC)cccc32)CC1	10.1021/jm049702f
		42618265	182668	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	378	8	1	4	3.7	O=c1[nH]c2ccccc2n1CCCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2009.02.008
		CHEMBL478905	182668	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	378	8	1	4	3.7	O=c1[nH]c2ccccc2n1CCCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2009.02.008
		44266229	207718	0	None	7	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	364	5	0	3	3.6	O=C1c2ccccc2CCCN1CCN1CCC(Oc2ccccc2)CC1	10.1016/s0960-894x(03)00077-5
		CHEMBL9564	207718	0	None	7	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	364	5	0	3	3.6	O=C1c2ccccc2CCCN1CCN1CCC(Oc2ccccc2)CC1	10.1016/s0960-894x(03)00077-5
		14566720	101895	11	None	-6	2	Rat	7.7	pKi	=	7.7	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	242	2	1	3	2.3	COc1ccc2cccc(N3CCNCC3)c2c1	10.1021/jm030826m
		CHEMBL300824	101895	11	None	-6	2	Rat	7.7	pKi	=	7.7	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	242	2	1	3	2.3	COc1ccc2cccc(N3CCNCC3)c2c1	10.1021/jm030826m
		11732538	204301	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	419	7	1	4	4.2	COc1ccc(N2CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC2)cc1	10.1021/jm0104264
		CHEMBL71390	204301	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	419	7	1	4	4.2	COc1ccc(N2CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC2)cc1	10.1021/jm0104264
		11725453	99080	0	None	1	6	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm030030n
		CHEMBL28056	99080	0	None	1	6	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm030030n
		90656669	110989	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	353	8	1	4	3.8	CCCN(CCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262422	110989	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	353	8	1	4	3.8	CCCN(CCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		11725453	99080	0	None	-1	6	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0108505
		CHEMBL28056	99080	0	None	-1	6	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0108505
		11397459	19357	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)	ChEMBL	479	9	0	5	4.7	COc1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL12908	19357	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)	ChEMBL	479	9	0	5	4.7	COc1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/j.bmc.2019.06.028
		11259115	19404	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)	ChEMBL	435	7	0	4	4.3	O=S1(=O)c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL12933	19404	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)	ChEMBL	435	7	0	4	4.3	O=S1(=O)c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2019.06.028
		11453756	19988	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)	ChEMBL	451	7	0	5	4.0	COc1ccccc1N1CCN(CCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL13032	19988	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)	ChEMBL	451	7	0	5	4.0	COc1ccccc1N1CCN(CCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/j.bmc.2019.06.028
		127040443	136709	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	382	9	1	4	3.2	CC(C)CS(=O)(=O)NC1CCN(CCOc2ccccc2C(C)C)CC1	10.1039/C5MD00166H
		CHEMBL3740624	136709	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	382	9	1	4	3.2	CC(C)CS(=O)(=O)NC1CCN(CCOc2ccccc2C(C)C)CC1	10.1039/C5MD00166H
		44439408	91215	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	426	4	0	5	4.9	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C1SCCSC1C3)CC2	10.1016/j.bmcl.2007.01.093
		CHEMBL240024	91215	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	426	4	0	5	4.9	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C1SCCSC1C3)CC2	10.1016/j.bmcl.2007.01.093
		44439396	91811	0	None	7	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	348	3	0	3	4.3	CC(=O)OC1CCCc2ccc(/N=C/N3CCc4ccccc4C3)cc21	10.1016/j.bmcl.2007.01.093
		CHEMBL241281	91811	0	None	7	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	348	3	0	3	4.3	CC(=O)OC1CCCc2ccc(/N=C/N3CCc4ccccc4C3)cc21	10.1016/j.bmcl.2007.01.093
		66800926	112091	0	None	6	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	488	7	1	7	4.0	Cc1c(S(=O)(=O)NCCCN2CCN(c3noc4ccccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
		CHEMBL3289985	112091	0	None	6	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	488	7	1	7	4.0	Cc1c(S(=O)(=O)NCCCN2CCN(c3noc4ccccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
		CHEMBL5284727	194259	0	None	-8	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis	ChEMBL	615	9	0	8	5.0	O=C1CC2CCc3ccsc3C2=NN1CCCCN1CCN(Cc2cccc3c2ccn3S(=O)(=O)c2ccccc2)CC1	10.1016/j.bmc.2023.117256
		2872937	117928	6	None	-2	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	464	4	1	5	4.7	O=S(=O)(Nc1cc2c(c3ccccc13)OC1(N3CCOCC3)CCCCC21)c1ccccc1	10.1016/j.bmcl.2015.03.049
		CHEMBL3403332	117928	6	None	-2	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	464	4	1	5	4.7	O=S(=O)(Nc1cc2c(c3ccccc13)OC1(N3CCOCC3)CCCCC21)c1ccccc1	10.1016/j.bmcl.2015.03.049
		127026145	137704	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	399	7	2	3	4.6	CC(C)c1ccccc1OCCN1CCC(NC(=O)Nc2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
		CHEMBL3758814	137704	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	399	7	2	3	4.6	CC(C)c1ccccc1OCCN1CCC(NC(=O)Nc2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
		CHEMBL5275394	193852	0	None	-10	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis	ChEMBL	601	9	0	8	4.6	O=C1CC2Cc3ccsc3C2=NN1CCCCN1CCN(Cc2cccc3c2ccn3S(=O)(=O)c2ccccc2)CC1	10.1016/j.bmc.2023.117256
		156010319	177042	0	None	-3	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	443	8	0	4	4.1	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2020.115459
		CHEMBL4632519	177042	0	None	-3	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	443	8	0	4	4.1	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2020.115459
		145978420	164001	0	None	2	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	486	7	1	4	3.1	O=S(=O)(NC1CCN(CCOc2cccc(I)c2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
		CHEMBL4208306	164001	0	None	2	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	486	7	1	4	3.1	O=S(=O)(NC1CCN(CCOc2cccc(I)c2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
		155546190	176485	0	None	-2	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	467	8	0	4	4.9	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2F)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4530770	176485	0	None	-2	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	467	8	0	4	4.9	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2F)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4596654	176485	0	None	-2	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	467	8	0	4	4.9	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2F)CC1	10.1016/j.bmc.2019.06.028
		42626291	192713	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	363	7	0	3	3.6	O=C1c2ccccc2CN1CCCCCN1CCN(c2ccccc2)CC1	10.1021/jm8014553
		CHEMBL521973	192713	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	363	7	0	3	3.6	O=C1c2ccccc2CN1CCCCCN1CCN(c2ccccc2)CC1	10.1021/jm8014553
		71462154	81363	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	396	9	1	4	4.1	CCOc1ccccc1C(=O)NC1CCN(CCOc2ccccc2C(C)C)C1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159311	81363	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	396	9	1	4	4.1	CCOc1ccccc1C(=O)NC1CCN(CCOc2ccccc2C(C)C)C1	10.1016/j.ejmech.2012.07.043
		145977555	163642	0	None	10	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccccc1Br	10.1021/acs.jmedchem.8b00828
		CHEMBL4204033	163642	0	None	10	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccccc1Br	10.1021/acs.jmedchem.8b00828
		CHEMBL5092755	215387	0	None	-120	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		Cc1ccc(S(=O)(=O)CC2CCN(CCCc3noc4cc(F)ccc34)C2)cc1C	10.1021/acs.jmedchem.1c00497
		5249591	169277	1	None	-257	2	Rat	5.7	pKi	=	5.7	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	419	4	0	5	3.4	COc1ccccc1N1CCN([C@H]2CC[C@H](N3C(=O)c4ccccc4C3=O)CC2)CC1	10.1016/j.bmcl.2004.09.029
		CHEMBL441313	169277	1	None	-257	2	Rat	5.7	pKi	=	5.7	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	419	4	0	5	3.4	COc1ccccc1N1CCN([C@H]2CC[C@H](N3C(=O)c4ccccc4C3=O)CC2)CC1	10.1016/j.bmcl.2004.09.029
		135398745	2914	112	None	-95	65	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.ejmech.2018.01.002
		47	2914	112	None	-95	65	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.ejmech.2018.01.002
		CHEMBL715	2914	112	None	-95	65	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.ejmech.2018.01.002
		DB00334	2914	112	None	-95	65	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.ejmech.2018.01.002
		155566191	175739	0	None	-67	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	362	7	3	4	4.5	COc1ccc2[nH]cc(CCNCc3ccc(-c4ccc(O)cc4)o3)c2c1	10.1016/j.ejmech.2019.111857
		CHEMBL4583082	175739	0	None	-67	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	362	7	3	4	4.5	COc1ccc2[nH]cc(CCNCc3ccc(-c4ccc(O)cc4)o3)c2c1	10.1016/j.ejmech.2019.111857
		57390694	70466	0	None	-9	6	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	385	5	0	4	5.1	Clc1ccc(N2CCCN(CCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.ejmech.2012.03.042
		CHEMBL1946255	70466	0	None	-9	6	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	385	5	0	4	5.1	Clc1ccc(N2CCCN(CCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.ejmech.2012.03.042
		53323186	57013	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	356	3	1	2	5.2	Clc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)c(Cl)c1	10.1016/j.bmcl.2010.11.078
		CHEMBL1644273	57013	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	356	3	1	2	5.2	Clc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)c(Cl)c1	10.1016/j.bmcl.2010.11.078
		155563452	175309	0	None	-40	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	361	6	0	4	3.7	O=C(CCCN1CCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
		CHEMBL4573441	175309	0	None	-40	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	361	6	0	4	3.7	O=C(CCCN1CCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
		57396417	71547	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	484	5	0	5	4.1	O=S(=O)(c1ccc2cccnc2c1)N1CCC(CN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
		CHEMBL1949975	71547	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	484	5	0	5	4.1	O=S(=O)(c1ccc2cccnc2c1)N1CCC(CN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
		CHEMBL1963009	71547	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	484	5	0	5	4.1	O=S(=O)(c1ccc2cccnc2c1)N1CCC(CN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
		44209472	70172	2	None	-114	11	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	315	6	0	4	2.8	Fc1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2011.12.019
		CHEMBL1940420	70172	2	None	-114	11	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	315	6	0	4	2.8	Fc1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2011.12.019
		134144304	154493	0	None	-2	9	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.4	O=C(CCCN1CCc2ccccc2CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
		CHEMBL3952251	154493	0	None	-2	9	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.4	O=C(CCCN1CCc2ccccc2CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
		CHEMBL3990525	154493	0	None	-2	9	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.4	O=C(CCCN1CCc2ccccc2CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
		155563452	175309	0	None	-40	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	361	6	0	4	3.7	O=C(CCCN1CCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
		CHEMBL4573441	175309	0	None	-40	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	361	6	0	4	3.7	O=C(CCCN1CCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
		752521	198737	8	None	-102	9	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	295	1	3	5	1.9	CC1(C)N=C(N)N=C(Nc2cccc(Br)c2)N1	10.1021/acs.jmedchem.5b01631
		CHEMBL582877	198737	8	None	-102	9	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	295	1	3	5	1.9	CC1(C)N=C(N)N=C(Nc2cccc(Br)c2)N1	10.1021/acs.jmedchem.5b01631
		145990093	167002	0	None	9	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	440	7	2	5	1.8	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(Cc3ccccc3)CC2)C1=O	10.1039/C8MD00168E
		CHEMBL4288077	167002	0	None	9	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	440	7	2	5	1.8	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(Cc3ccccc3)CC2)C1=O	10.1039/C8MD00168E
		137649997	157289	0	None	3	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	464	6	0	5	3.8	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3ccccc3)CC2)CC1	10.1016/j.bmc.2017.04.046
		CHEMBL4076903	157289	0	None	3	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	464	6	0	5	3.8	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3ccccc3)CC2)CC1	10.1016/j.bmc.2017.04.046
		145992305	166999	0	None	5	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	371	5	2	6	0.4	CC1(C)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1039/C8MD00168E
		CHEMBL4288040	166999	0	None	5	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	371	5	2	6	0.4	CC1(C)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1039/C8MD00168E
		46205369	124583	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	287	3	1	2	4.0	Cc1ccc(-c2ccc(Cl)cc2OC2CNC2)cc1C	nan
		CHEMBL3640589	124583	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	287	3	1	2	4.0	Cc1ccc(-c2ccc(Cl)cc2OC2CNC2)cc1C	nan
		46206019	124599	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	237	2	1	1	3.7	Cc1ccccc1-c1ccccc1C1CCNC1	nan
		CHEMBL3640605	124599	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	237	2	1	1	3.7	Cc1ccccc1-c1ccccc1C1CCNC1	nan
		46205369	124583	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	287	3	1	2	4.0	Cc1ccc(-c2ccc(Cl)cc2OC2CNC2)cc1C	nan
		CHEMBL3640589	124583	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	287	3	1	2	4.0	Cc1ccc(-c2ccc(Cl)cc2OC2CNC2)cc1C	nan
		46206019	124599	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	237	2	1	1	3.7	Cc1ccccc1-c1ccccc1C1CCNC1	nan
		CHEMBL3640605	124599	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	237	2	1	1	3.7	Cc1ccccc1-c1ccccc1C1CCNC1	nan
		155537074	172270	0	None	-147	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	362	7	3	4	4.5	COc1cccc2[nH]cc(CCNCc3ccc(-c4ccc(O)cc4)o3)c12	10.1016/j.ejmech.2019.111857
		CHEMBL4474618	172270	0	None	-147	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	362	7	3	4	4.5	COc1cccc2[nH]cc(CCNCc3ccc(-c4ccc(O)cc4)o3)c12	10.1016/j.ejmech.2019.111857
		46203751	124543	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2ccc(F)cc2C)cc1OC1CNC1	nan
		CHEMBL3640551	124543	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2ccc(F)cc2C)cc1OC1CNC1	nan
		44388858	61497	0	None	-2	4	Rat	7.7	pKi	=	7.7	Binding	Binding affinity against rat 5-HT7R expressed in HEK293 cellsBinding affinity against rat 5-HT7R expressed in HEK293 cells	ChEMBL	361	5	0	4	4.1	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1	10.1016/j.bmcl.2005.05.059
		CHEMBL177064	61497	0	None	-2	4	Rat	7.7	pKi	=	7.7	Binding	Binding affinity against rat 5-HT7R expressed in HEK293 cellsBinding affinity against rat 5-HT7R expressed in HEK293 cells	ChEMBL	361	5	0	4	4.1	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1	10.1016/j.bmcl.2005.05.059
		44388858	61497	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	361	5	0	4	4.1	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1	10.1016/j.ejmech.2014.01.055
		CHEMBL177064	61497	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	361	5	0	4	4.1	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1	10.1016/j.ejmech.2014.01.055
		76320704	103538	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	352	1	0	2	5.2	CC1=CC=CC(C#N)[C@H]1c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm049743b
		CHEMBL3085300	103538	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	352	1	0	2	5.2	CC1=CC=CC(C#N)[C@H]1c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm049743b
		2726	919	68	None	-13	72	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030030n
		621	919	68	None	-13	72	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030030n
		83	919	68	None	-13	72	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030030n
		CHEMBL71	919	68	None	-13	72	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030030n
		DB00477	919	68	None	-13	72	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030030n
		68788	207607	14	None	-1	2	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	348	3	2	3	1.3	CN1C[C@@H](NS(=O)(=O)N(C)C)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/jm030030n
		CHEMBL95067	207607	14	None	-1	2	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	348	3	2	3	1.3	CN1C[C@@H](NS(=O)(=O)N(C)C)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/jm030030n
		46203751	124543	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2ccc(F)cc2C)cc1OC1CNC1	nan
		CHEMBL3640551	124543	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2ccc(F)cc2C)cc1OC1CNC1	nan
		145975720	163960	0	None	2	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	394	4	1	4	2.5	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccc(F)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
		CHEMBL4207835	163960	0	None	2	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	394	4	1	4	2.5	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccc(F)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
		134151118	152201	0	None	3	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	498	12	1	4	5.4	CN(C)Cc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		CHEMBL3968569	152201	0	None	3	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	498	12	1	4	5.4	CN(C)Cc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		71453278	81424	0	None	-1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	422	7	1	3	4.5	O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1cccc(F)c1F	10.1016/j.ejmech.2012.07.043
		CHEMBL2159467	81424	0	None	-1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	422	7	1	3	4.5	O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1cccc(F)c1F	10.1016/j.ejmech.2012.07.043
		135398737	958	93	None	-13	89	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2022.114193
		38	958	93	None	-13	89	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2022.114193
		722	958	93	None	-13	89	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2022.114193
		CHEMBL42	958	93	None	-13	89	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2022.114193
		DB00363	958	93	None	-13	89	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2022.114193
		71574204	86267	0	None	-2	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cncc2ccccc12	10.1016/j.ejmech.2012.11.042
		CHEMBL2312640	86267	0	None	-2	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cncc2ccccc12	10.1016/j.ejmech.2012.11.042
		155557443	174644	0	None	9	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	245	2	1	3	2.7	COc1ccc2[nH]cc(-c3cncn3C)c2c1F	10.1016/j.ejmech.2019.03.017
		CHEMBL4558202	174644	0	None	9	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	245	2	1	3	2.7	COc1ccc2[nH]cc(-c3cncn3C)c2c1F	10.1016/j.ejmech.2019.03.017
		127037682	136593	0	None	4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	453	8	1	5	4.2	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cncc3ccccc23)CC1	10.1039/C5MD00166H
		CHEMBL3739561	136593	0	None	4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	453	8	1	5	4.2	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cncc3ccccc23)CC1	10.1039/C5MD00166H
		42618269	90987	0	None	-6	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	397	6	0	4	3.1	O=C1CCCC(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2007.07.029
		CHEMBL239680	90987	0	None	-6	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	397	6	0	4	3.1	O=C1CCCC(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2007.07.029
		24854109	161286	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	397	6	1	3	4.5	CCC1(CCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		CHEMBL412143	161286	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	397	6	1	3	4.5	CCC1(CCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		136180317	117711	0	None	-7	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	396	6	1	4	3.7	O=c1[nH]c(CCCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
		CHEMBL3401479	117711	0	None	-7	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	396	6	1	4	3.7	O=c1[nH]c(CCCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
		CHEMBL5082182	214793	1	None	-4	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1cccc(Cl)c1	10.1021/acs.jmedchem.1c00497
		44324403	206885	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	265	2	2	3	3.3	Cc1cccc(-c2cccc(NC3=NCCN3)c2C)c1	10.1016/s0960-894x(02)00925-3
		CHEMBL90752	206885	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	265	2	2	3	3.3	Cc1cccc(-c2cccc(NC3=NCCN3)c2C)c1	10.1016/s0960-894x(02)00925-3
		11811833	103069	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	418	7	1	3	5.0	COC1(c2ccccc2)CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
		CHEMBL307352	103069	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	418	7	1	3	5.0	COC1(c2ccccc2)CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
		CHEMBL5077755	214513	0	None	-12	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1ccc(Cl)c(Cl)c1	10.1021/acs.jmedchem.1c00497
		57401515	68398	0	None	-32	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	498	8	0	5	4.0	COc1ccccc1N1CCN(CCCN2C(=O)N(C)C(=O)C2(c2ccccc2)c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
		CHEMBL1916745	68398	0	None	-32	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	498	8	0	5	4.0	COc1ccccc1N1CCN(CCCN2C(=O)N(C)C(=O)C2(c2ccccc2)c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
		44582676	189779	0	None	-1	17	Human	6.7	pKi	=	6.7	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	403	9	0	4	4.3	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL516088	189779	0	None	-1	17	Human	6.7	pKi	=	6.7	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	403	9	0	4	4.3	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		11373934	84679	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	435	9	1	4	4.6	COc1ccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)cc1	10.1021/jm049702f
		CHEMBL222507	84679	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	435	9	1	4	4.6	COc1ccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)cc1	10.1021/jm049702f
		CHEMBL5283557	194217	0	None	-2	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis	ChEMBL	484	6	0	5	4.8	O=C1CC2CCc3ccsc3C2=NN1Cc1ccc(CN2CCN(Cc3ccccc3)CC2)cc1	10.1016/j.bmc.2023.117256
		60165537	75351	0	None	-1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	308	5	0	3	4.6	c1ccc2c(c1)CN(CCCCc1nc3ccccc3s1)C2	10.1016/j.ejmech.2012.03.042
		CHEMBL2037523	75351	0	None	-1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	308	5	0	3	4.6	c1ccc2c(c1)CN(CCCCc1nc3ccccc3s1)C2	10.1016/j.ejmech.2012.03.042
		73213195	104459	0	None	-7	12	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
		CHEMBL3104092	104459	0	None	-7	12	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
		22065997	99355	0	None	-64	4	Human	6.7	pKi	=	6.7	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	310	3	1	3	3.0	Fc1ccccc1N1CCN(Cc2c[nH]c3ncccc23)CC1	10.1016/s0960-894x(01)00241-4
		CHEMBL282424	99355	0	None	-64	4	Human	6.7	pKi	=	6.7	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	310	3	1	3	3.0	Fc1ccccc1N1CCN(Cc2c[nH]c3ncccc23)CC1	10.1016/s0960-894x(01)00241-4
		145964694	164037	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	450	9	2	5	3.1	CC(C)c1ccccc1OCC(O)CN1CCC(NS(=O)(=O)c2cccc(F)c2)CC1	10.1016/j.bmc.2017.03.057
		CHEMBL4208791	164037	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	450	9	2	5	3.1	CC(C)c1ccccc1OCC(O)CN1CCC(NS(=O)(=O)c2cccc(F)c2)CC1	10.1016/j.bmc.2017.03.057
		145947301	167664	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3F)C2=O)CC1	10.1016/j.ejmech.2018.01.093
		CHEMBL4160262	167664	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3F)C2=O)CC1	10.1016/j.ejmech.2018.01.093
		CHEMBL4301925	167664	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3F)C2=O)CC1	10.1016/j.ejmech.2018.01.093
		145976787	163626	0	None	20	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	428	7	1	4	3.5	O=S(=O)(NC1CCN(CCOc2ccccc2C(F)(F)F)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
		CHEMBL4203823	163626	0	None	20	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	428	7	1	4	3.5	O=S(=O)(NC1CCN(CCOc2ccccc2C(F)(F)F)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
		118728529	117725	0	None	-8	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	444	7	0	6	4.7	Cc1sc2ncn(CCCCCN3CCN(c4ccc(Cl)cc4)CC3)c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
		CHEMBL3401492	117725	0	None	-8	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	444	7	0	6	4.7	Cc1sc2ncn(CCCCCN3CCN(c4ccc(Cl)cc4)CC3)c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
		155564110	175369	0	None	-23	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	375	6	0	4	4.0	O=C(CCCN1CCCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
		CHEMBL4574793	175369	0	None	-23	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	375	6	0	4	4.0	O=C(CCCN1CCCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
		122483297	138091	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	320	5	0	3	4.7	O=C(CCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3763670	138091	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	320	5	0	3	4.7	O=C(CCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765839	138091	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	320	5	0	3	4.7	O=C(CCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		155564110	175369	0	None	-23	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	375	6	0	4	4.0	O=C(CCCN1CCCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
		CHEMBL4574793	175369	0	None	-23	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	375	6	0	4	4.0	O=C(CCCN1CCCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
		22330705	117942	8	None	-1	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	438	3	0	3	5.5	Cc1ccc(Cl)cc1N(C)C(=O)c1cn(-c2ccc(F)cc2F)c(=O)c2ccccc12	10.1016/j.bmcl.2015.03.049
		CHEMBL3403345	117942	8	None	-1	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	438	3	0	3	5.5	Cc1ccc(Cl)cc1N(C)C(=O)c1cn(-c2ccc(F)cc2F)c(=O)c2ccccc12	10.1016/j.bmcl.2015.03.049
		25107650	187285	0	None	-23	3	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	407	10	1	3	4.8	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	10.1021/jm800615e
		CHEMBL492872	187285	0	None	-23	3	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	407	10	1	3	4.8	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	10.1021/jm800615e
		122483297	138091	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	320	5	0	3	4.7	O=C(CCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3763670	138091	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	320	5	0	3	4.7	O=C(CCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765839	138091	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	320	5	0	3	4.7	O=C(CCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		155569568	176194	0	None	-32	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	380	7	2	3	5.4	COc1ccc2[nH]cc(CCNCc3ccc(-c4ccc(Cl)cc4)o3)c2c1	10.1016/j.ejmech.2019.111857
		CHEMBL4593671	176194	0	None	-32	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	380	7	2	3	5.4	COc1ccc2[nH]cc(CCNCc3ccc(-c4ccc(Cl)cc4)o3)c2c1	10.1016/j.ejmech.2019.111857
		145990459	166962	0	None	2	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	490	7	2	5	2.9	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(Cc3cccc4ccccc34)CC2)C1=O	10.1039/C8MD00168E
		CHEMBL4287320	166962	0	None	2	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	490	7	2	5	2.9	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(Cc3cccc4ccccc34)CC2)C1=O	10.1039/C8MD00168E
		71602689	89686	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2cccc(Cl)c2)CC1	10.1016/j.bmc.2013.02.038
		CHEMBL2376458	89686	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2cccc(Cl)c2)CC1	10.1016/j.bmc.2013.02.038
		162669595	182744	0	None	-24	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	489	7	1	6	5.0	Cc1c(S(=O)(=O)N[C@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(Cl)cc12	10.1016/j.ejmech.2020.112149
		CHEMBL4790020	182744	0	None	-24	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	489	7	1	6	5.0	Cc1c(S(=O)(=O)N[C@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(Cl)cc12	10.1016/j.ejmech.2020.112149
		71602689	89686	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2cccc(Cl)c2)CC1	10.1016/j.bmc.2013.02.038
		CHEMBL2376458	89686	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2cccc(Cl)c2)CC1	10.1016/j.bmc.2013.02.038
		71456780	81419	0	None	-7	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	426	8	1	4	3.5	O=S(=O)(NCC1CCN(CCOc2cccc(F)c2)CC1)c1cccc(Cl)c1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159462	81419	0	None	-7	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	426	8	1	4	3.5	O=S(=O)(NCC1CCN(CCOc2cccc(F)c2)CC1)c1cccc(Cl)c1	10.1016/j.ejmech.2012.07.043
		44374225	54746	0	None	54	3	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	244	4	0	4	3.1	CN(C)CCSc1nc(C(C)(C)C)cs1	10.1016/j.bmcl.2003.11.050
		CHEMBL161203	54746	0	None	54	3	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	244	4	0	4	3.1	CN(C)CCSc1nc(C(C)(C)C)cs1	10.1016/j.bmcl.2003.11.050
		90654687	110108	0	None	10	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	475	8	1	6	2.9	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235759	110108	0	None	10	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	475	8	1	6	2.9	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
		145986031	165822	0	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	0	6	5.2	O=S(=O)(c1cccc2ncccc12)N1CCCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4248544	165822	0	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	0	6	5.2	O=S(=O)(c1cccc2ncccc12)N1CCCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
		118731361	118197	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	558	10	0	4	5.8	CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2Cc3ccccc3C[C@H]2C(=O)N2CCCCC2)CC1	10.1016/j.ejmech.2014.12.041
		CHEMBL3409044	118197	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	558	10	0	4	5.8	CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2Cc3ccccc3C[C@H]2C(=O)N2CCCCC2)CC1	10.1016/j.ejmech.2014.12.041
		139488527	169533	0	None	42	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	272	3	2	3	2.3	CCn1cncc1-c1c[nH]c2ccc(C(N)=O)c(F)c12	10.1016/j.ejmech.2019.03.017
		CHEMBL4435235	169533	0	None	42	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	272	3	2	3	2.3	CCn1cncc1-c1c[nH]c2ccc(C(N)=O)c(F)c12	10.1016/j.ejmech.2019.03.017
		56660668	177100	0	None	5	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	301	2	0	1	4.9	CN(C)C1CCc2c(cccc2-c2cccc3ccccc23)C1	10.1016/j.bmc.2019.115262
		CHEMBL4633326	177100	0	None	5	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	301	2	0	1	4.9	CN(C)C1CCc2c(cccc2-c2cccc3ccccc23)C1	10.1016/j.bmc.2019.115262
		155561978	175826	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	518	8	1	6	4.1	COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
		CHEMBL4584900	175826	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	518	8	1	6	4.1	COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
		42625445	186778	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	399	6	0	3	4.3	O=C1Cc2ccccc2N1CCCCN1CCN(c2cccc3ccccc23)CC1	10.1016/j.ejmech.2014.08.023
		CHEMBL489028	186778	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	399	6	0	3	4.3	O=C1Cc2ccccc2N1CCCCN1CCN(c2cccc3ccccc23)CC1	10.1016/j.ejmech.2014.08.023
		21963826	76751	5	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	398	7	0	4	4.0	O=S(=O)(c1ccccc1)C1(CCCN2CCN(c3ccccc3)CC2)CCC1	10.1016/j.bmcl.2005.11.067
		CHEMBL206747	76751	5	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	398	7	0	4	4.0	O=S(=O)(c1ccccc1)C1(CCCN2CCN(c3ccccc3)CC2)CCC1	10.1016/j.bmcl.2005.11.067
		118711997	114082	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	487	11	1	5	5.0	COc1cccc(-c2ccccc2CNC(=O)CCCCN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2014.07.026
		CHEMBL3326986	114082	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	487	11	1	5	5.0	COc1cccc(-c2ccccc2CNC(=O)CCCCN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2014.07.026
		122178707	121373	0	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	395	6	0	5	4.3	COc1cc2c(cc1OCC1CC1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
		CHEMBL3581252	121373	0	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	395	6	0	5	4.3	COc1cc2c(cc1OCC1CC1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
		25107649	187257	0	None	-1	3	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	411	10	1	4	4.4	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	10.1021/jm800615e
		CHEMBL492691	187257	0	None	-1	3	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	411	10	1	4	4.4	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	10.1021/jm800615e
		142601333	185763	0	None	36	6	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	260	2	2	3	2.0	Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
		CHEMBL4866412	185763	0	None	36	6	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	260	2	2	3	2.0	Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
		127051592	140878	0	None	1	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818710	140878	0	None	1	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3819742	140878	0	None	1	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
		44340897	9711	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	377	5	1	4	2.9	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3c(c2)NCC3)CC1	10.1016/s0960-894x(02)00690-x
		CHEMBL113192	9711	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	377	5	1	4	2.9	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3c(c2)NCC3)CC1	10.1016/s0960-894x(02)00690-x
		164609650	184997	0	None	1	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	389	4	0	4	4.0	O=C1c2cc(Cl)c(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
		CHEMBL4854456	184997	0	None	1	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	389	4	0	4	4.0	O=C1c2cc(Cl)c(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
		164611932	185202	0	None	-5	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	364	6	1	4	3.1	O=C1CCc2cc(CCCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
		CHEMBL4857597	185202	0	None	-5	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	364	6	1	4	3.1	O=C1CCc2cc(CCCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
		127051592	140878	0	None	1	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818710	140878	0	None	1	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3819742	140878	0	None	1	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
		71602690	89687	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2013.02.038
		CHEMBL2376459	89687	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2013.02.038
		53323185	57008	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	288	3	1	2	3.8	c1ccc(Cn2cc(-c3ccccc3)c3c2CCNC3)cc1	10.1016/j.bmcl.2010.11.078
		CHEMBL1644268	57008	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	288	3	1	2	3.8	c1ccc(Cn2cc(-c3ccccc3)c3c2CCNC3)cc1	10.1016/j.bmcl.2010.11.078
		44439397	91212	0	None	22	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	4	0	5	4.7	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)N(C(=O)OC(C)(C)C)CC3)CC2	10.1016/j.bmcl.2007.01.093
		CHEMBL240021	91212	0	None	22	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	4	0	5	4.7	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)N(C(=O)OC(C)(C)C)CC3)CC2	10.1016/j.bmcl.2007.01.093
		11453751	90960	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	451	3	0	4	4.3	CC1(C)CC(=O)N(C2CCC(N3CCN(c4cccc(C(F)(F)F)c4)CC3)CC2)C(=O)C1	10.1016/j.bmc.2007.07.029
		CHEMBL239467	90960	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	451	3	0	4	4.3	CC1(C)CC(=O)N(C2CCC(N3CCN(c4cccc(C(F)(F)F)c4)CC3)CC2)C(=O)C1	10.1016/j.bmc.2007.07.029
		13069655	120607	0	None	-18	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	412	6	0	9	0.7	COc1ccccc1N1CCN(CCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1	10.1016/j.bmc.2014.11.008
		CHEMBL3360992	120607	0	None	-18	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	412	6	0	9	0.7	COc1ccccc1N1CCN(CCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1	10.1016/j.bmc.2014.11.008
		CHEMBL3546106	120607	0	None	-18	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	412	6	0	9	0.7	COc1ccccc1N1CCN(CCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1	10.1016/j.bmc.2014.11.008
		164608999	184384	0	None	-18	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	310	6	1	4	2.8	Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
		CHEMBL4845741	184384	0	None	-18	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	310	6	1	4	2.8	Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
		71451454	81412	0	None	-2	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	398	8	1	5	3.0	O=S(=O)(NCC1CCN(CCOc2cccc(F)c2)CC1)c1cccs1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159456	81412	0	None	-2	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	398	8	1	5	3.0	O=S(=O)(NCC1CCN(CCOc2cccc(F)c2)CC1)c1cccs1	10.1016/j.ejmech.2012.07.043
		71460456	81370	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	382	6	1	3	3.6	O=C(NC1CCN(CCOc2cccc3c2CCCC3)C1)c1cccc(F)c1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159318	81370	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	382	6	1	3	3.6	O=C(NC1CCN(CCOc2cccc3c2CCCC3)C1)c1cccc(F)c1	10.1016/j.ejmech.2012.07.043
		127028152	138205	0	None	12	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	426	6	2	5	1.8	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
		CHEMBL3769836	138205	0	None	12	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	426	6	2	5	1.8	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
		90654681	110102	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	454	7	1	4	3.1	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235753	110102	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	454	7	1	4	3.1	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2014.03.005
		11133795	203774	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	431	7	2	3	3.9	NC(=O)C1(c2ccccc2)CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
		CHEMBL68094	203774	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	431	7	2	3	3.9	NC(=O)C1(c2ccccc2)CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
		117209864	186034	1	None	1	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
		CHEMBL4870675	186034	1	None	1	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
		164617626	185460	0	None	-9	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	324	6	1	5	2.4	Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
		CHEMBL4861794	185460	0	None	-9	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	324	6	1	5	2.4	Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
		57402588	68426	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	395	7	1	4	3.4	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1ccc2ncccc2c1	10.1016/j.bmc.2011.09.044
		CHEMBL1917347	68426	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	395	7	1	4	3.4	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1ccc2ncccc2c1	10.1016/j.bmc.2011.09.044
		145992567	166776	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	548	8	2	5	4.4	CC1(c2cccc3ccccc23)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1039/C8MD00168E
		CHEMBL4283960	166776	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	548	8	2	5	4.4	CC1(c2cccc3ccccc23)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1039/C8MD00168E
		25107519	187669	0	None	-17	3	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	395	10	1	4	3.7	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	10.1021/jm800615e
		CHEMBL495120	187669	0	None	-17	3	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	395	10	1	4	3.7	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	10.1021/jm800615e
		46233349	200299	5	None	-2	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	244	4	0	3	1.8	CN(C)CCOc1cccc(Br)n1	10.1016/j.bmc.2010.01.035
		CHEMBL597356	200299	5	None	-2	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	244	4	0	3	1.8	CN(C)CCOc1cccc(Br)n1	10.1016/j.bmc.2010.01.035
		129103318	167314	0	None	-309	14	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat cerebral cortex homogenates after 30 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat cerebral cortex homogenates after 30 mins by liquid scintillation counting	ChEMBL	475	7	0	5	5.0	O=C(CCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2	10.1021/acs.jmedchem.8b01096
		CHEMBL4293999	167314	0	None	-309	14	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat cerebral cortex homogenates after 30 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat cerebral cortex homogenates after 30 mins by liquid scintillation counting	ChEMBL	475	7	0	5	5.0	O=C(CCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2	10.1021/acs.jmedchem.8b01096
		117209864	186034	1	None	1	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
		CHEMBL4870675	186034	1	None	1	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
		90656698	112608	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	366	9	1	3	5.3	CN(CCCCCCN1CCC(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262431	112608	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	366	9	1	3	5.3	CN(CCCCCCN1CCC(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3302234	112608	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	366	9	1	3	5.3	CN(CCCCCCN1CCC(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		43840296	150304	2	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	227	4	1	2	3.1	CNCc1cccc(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
		CHEMBL3952849	150304	2	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	227	4	1	2	3.1	CNCc1cccc(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
		3303	2244	46	None	-338	15	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/s0960-894x(01)00241-4
		5311200	2244	46	None	-338	15	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/s0960-894x(01)00241-4
		CHEMBL267014	2244	46	None	-338	15	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/s0960-894x(01)00241-4
		46205045	124580	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	392	6	1	3	4.2	CCN(CC)C(=O)c1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
		CHEMBL3640586	124580	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	392	6	1	3	4.2	CCN(CC)C(=O)c1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
		46205045	124580	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	392	6	1	3	4.2	CCN(CC)C(=O)c1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
		CHEMBL3640586	124580	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	392	6	1	3	4.2	CCN(CC)C(=O)c1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
		57395598	68425	0	None	1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	395	7	1	4	3.4	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.09.044
		CHEMBL1917346	68425	0	None	1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	395	7	1	4	3.4	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.09.044
		145976722	163989	0	None	2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	516	7	1	4	4.0	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1ccccc1Br	10.1021/acs.jmedchem.8b00828
		CHEMBL4208165	163989	0	None	2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	516	7	1	4	4.0	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1ccccc1Br	10.1021/acs.jmedchem.8b00828
		136180319	117713	0	None	-5	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	376	7	1	4	3.5	O=c1[nH]c(CCCCCN2CCN(c3ccccc3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
		CHEMBL3401481	117713	0	None	-5	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	376	7	1	4	3.5	O=c1[nH]c(CCCCCN2CCN(c3ccccc3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
		60165418	75349	0	None	-281	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	353	6	0	6	3.2	c1cnc(N2CCN(CCCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.ejmech.2012.03.042
		CHEMBL2037521	75349	0	None	-281	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	353	6	0	6	3.2	c1cnc(N2CCN(CCCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.ejmech.2012.03.042
		851853	191318	13	None	-3	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	239	1	1	2	1.5	NC(=O)N1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2022.114319
		CHEMBL5191370	191318	13	None	-3	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	239	1	1	2	1.5	NC(=O)N1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2022.114319
		53320865	57022	0	None	-	1	Rat	4.6	pKi	=	4.6	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	322	3	1	2	4.5	Clc1ccccc1Cn1cc(-c2ccccc2)c2c1CCNC2	10.1016/j.bmcl.2010.11.078
		CHEMBL1644484	57022	0	None	-	1	Rat	4.6	pKi	=	4.6	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	322	3	1	2	4.5	Clc1ccccc1Cn1cc(-c2ccccc2)c2c1CCNC2	10.1016/j.bmcl.2010.11.078
		11341394	84672	0	None	2	3	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	448	9	2	4	3.7	NC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
		CHEMBL222489	84672	0	None	2	3	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	448	9	2	4	3.7	NC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
		168290928	191856	0	None	-10	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	501	6	0	7	4.3	COc1cc2ncnc(N3CCC(CN4CCN(c5cccc(C(F)(F)F)c5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
		CHEMBL5199182	191856	0	None	-10	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	501	6	0	7	4.3	COc1cc2ncnc(N3CCC(CN4CCN(c5cccc(C(F)(F)F)c5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
		162650168	180106	0	None	-389	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	455	7	1	6	4.3	Cc1ccc2sc(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)cc2c1	10.1016/j.ejmech.2020.112149
		CHEMBL4748379	180106	0	None	-389	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	455	7	1	6	4.3	Cc1ccc2sc(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)cc2c1	10.1016/j.ejmech.2020.112149
		162651619	180311	0	None	-288	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	475	7	1	6	4.7	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(Cl)cc2s1	10.1016/j.ejmech.2020.112149
		CHEMBL4751063	180311	0	None	-288	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	475	7	1	6	4.7	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(Cl)cc2s1	10.1016/j.ejmech.2020.112149
		44393052	65273	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	378	9	2	7	3.6	C[C@H](Nc1nc(NCCOc2ccccc2)nc(N(C)C)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
		CHEMBL182840	65273	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	378	9	2	7	3.6	C[C@H](Nc1nc(NCCOc2ccccc2)nc(N(C)C)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
		58405183	110697	0	None	-4	4	Rat	7.6	pKi	=	7.6	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	339	6	1	3	3.9	FC(F)(COc1ccc(Cl)cc1OC1CNC1)c1ccccc1	10.1021/ml500082j
		CHEMBL3260336	110697	0	None	-4	4	Rat	7.6	pKi	=	7.6	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	339	6	1	3	3.9	FC(F)(COc1ccc(Cl)cc1OC1CNC1)c1ccccc1	10.1021/ml500082j
		209	3057	97	None	-31	23	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1021/jm030030n
		2113	3057	97	None	-31	23	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1021/jm030030n
		4748	3057	97	None	-31	23	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1021/jm030030n
		CHEMBL567	3057	97	None	-31	23	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1021/jm030030n
		DB00850	3057	97	None	-31	23	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1021/jm030030n
		44460725	105641	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	325	3	0	3	3.3	CN1CCCN(CCn2ccc3ccc(C(F)(F)F)cc32)CC1	10.1016/s0960-894x(02)00438-9
		CHEMBL312489	105641	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	325	3	0	3	3.3	CN1CCCN(CCn2ccc3ccc(C(F)(F)F)cc32)CC1	10.1016/s0960-894x(02)00438-9
		118626045	165668	0	None	-4	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cccc2cnccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4244691	165668	0	None	-4	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cccc2cnccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
		145947359	167655	0	None	9	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	463	7	2	7	1.5	COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(c4ccccc4C#N)CC3)C2=O)cc1	10.1016/j.ejmech.2018.01.093
		CHEMBL4171652	167655	0	None	9	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	463	7	2	7	1.5	COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(c4ccccc4C#N)CC3)C2=O)cc1	10.1016/j.ejmech.2018.01.093
		CHEMBL4301757	167655	0	None	9	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	463	7	2	7	1.5	COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(c4ccccc4C#N)CC3)C2=O)cc1	10.1016/j.ejmech.2018.01.093
		60196074	81816	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	239	2	1	3	2.2	c1ccc(-c2ccccc2N2CCNCC2)nc1	10.1021/jm3003679
		CHEMBL2164340	81816	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	239	2	1	3	2.2	c1ccc(-c2ccccc2N2CCNCC2)nc1	10.1021/jm3003679
		155537788	172351	0	None	16	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	436	6	1	6	4.4	O=c1[nH]c(SCCCN2CCN(c3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
		CHEMBL4475894	172351	0	None	16	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	436	6	1	6	4.4	O=c1[nH]c(SCCCN2CCN(c3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
		117209965	185247	1	None	3	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4858338	185247	1	None	3	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		142601333	185763	0	None	36	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	260	2	2	3	2.0	Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
		CHEMBL4866412	185763	0	None	36	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	260	2	2	3	2.0	Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
		164609650	184997	0	None	1	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	389	4	0	4	4.0	O=C1c2cc(Cl)c(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
		CHEMBL4854456	184997	0	None	1	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	389	4	0	4	4.0	O=C1c2cc(Cl)c(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
		10593348	97295	0	None	4	4	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	341	1	1	2	5.1	Cc1cccc(O)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0108505
		CHEMBL26907	97295	0	None	4	4	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	341	1	1	2	5.1	Cc1cccc(O)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0108505
		134134210	143785	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	255	4	0	2	3.7	COc1ccccc1-c1cc(CN(C)C)ccc1C	10.1016/j.ejmech.2016.07.029
		CHEMBL3901042	143785	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	255	4	0	2	3.7	COc1ccccc1-c1cc(CN(C)C)ccc1C	10.1016/j.ejmech.2016.07.029
		68281136	112055	0	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	422	7	1	7	2.8	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cccs1	10.1021/jm401895u
		CHEMBL3289950	112055	0	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	422	7	1	7	2.8	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cccs1	10.1021/jm401895u
		122178710	121376	0	None	3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	431	6	0	5	5.0	COc1cc2c(cc1OCc1ccccc1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
		CHEMBL3581255	121376	0	None	3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	431	6	0	5	5.0	COc1cc2c(cc1OCc1ccccc1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
		135458410	167189	0	None	-4	6	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	293	2	2	3	3.5	CC1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.078
		CHEMBL429136	167189	0	None	-4	6	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	293	2	2	3	3.5	CC1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.078
		117209965	185247	1	None	3	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4858338	185247	1	None	3	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		153287542	169534	0	None	6	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	265	1	1	2	3.6	C[C@@]12COc3c(-c4ccccc4)cccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
		CHEMBL4435237	169534	0	None	6	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	265	1	1	2	3.6	C[C@@]12COc3c(-c4ccccc4)cccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
		109026957	171836	2	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	394	6	0	6	1.3	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ncccn2)CC1	10.1016/j.bmcl.2016.06.080
		CHEMBL4468683	171836	2	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	394	6	0	6	1.3	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ncccn2)CC1	10.1016/j.bmcl.2016.06.080
		132547276	142160	0	None	-3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	446	11	0	6	4.9	CCOc1ccccc1N1CCN(CCCCCOc2cc(-c3ccccc3)ncn2)CC1	10.1016/j.bmc.2016.12.039
		CHEMBL3883640	142160	0	None	-3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	446	11	0	6	4.9	CCOc1ccccc1N1CCN(CCCCCOc2cc(-c3ccccc3)ncn2)CC1	10.1016/j.bmc.2016.12.039
		71061756	93119	0	None	38	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccccn3)CC2)cc1	10.1016/j.bmc.2014.01.016
		CHEMBL2442997	93119	0	None	38	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccccn3)CC2)cc1	10.1016/j.bmc.2014.01.016
		71061756	93119	0	None	38	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccccn3)CC2)cc1	10.1016/j.bmcl.2013.09.025
		CHEMBL2442997	93119	0	None	38	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccccn3)CC2)cc1	10.1016/j.bmcl.2013.09.025
		162666163	182381	0	None	22	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	532	10	0	6	6.7	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc(-c4cn5ccccc5n4)cc3)CC2)cc1	10.1016/j.ejmech.2020.112395
		CHEMBL4785158	182381	0	None	22	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	532	10	0	6	6.7	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc(-c4cn5ccccc5n4)cc3)CC2)cc1	10.1016/j.ejmech.2020.112395
		11825129	48772	0	None	-1	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	382	9	1	5	4.0	COc1ccccc1N1CCN(CCCCCC(=O)c2ccc(O)cc2)CC1	10.1021/jm020994z
		CHEMBL155861	48772	0	None	-1	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	382	9	1	5	4.0	COc1ccccc1N1CCN(CCCCCC(=O)c2ccc(O)cc2)CC1	10.1021/jm020994z
		71061659	93120	0	None	53	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3cccnc3)CC2)cc1	10.1016/j.bmc.2014.01.016
		CHEMBL2442998	93120	0	None	53	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3cccnc3)CC2)cc1	10.1016/j.bmc.2014.01.016
		71061659	93120	0	None	53	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3cccnc3)CC2)cc1	10.1016/j.bmcl.2013.09.025
		CHEMBL2442998	93120	0	None	53	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3cccnc3)CC2)cc1	10.1016/j.bmcl.2013.09.025
		11059148	203913	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	434	7	1	5	4.1	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1)CCC3	10.1021/jm0104264
		CHEMBL69040	203913	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	434	7	1	5	4.1	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1)CCC3	10.1021/jm0104264
		118736365	118937	0	None	-32	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	465	7	1	10	1.4	Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccccc5O)CC4)ccn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
		CHEMBL3423329	118937	0	None	-32	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	465	7	1	10	1.4	Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccccc5O)CC4)ccn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
		2232766	161371	7	None	-42	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hrDisplacement of [3H]-5-carboxyamidotryptamine from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr	ChEMBL	297	7	0	2	4.9	c1ccc2c(OCCCCCN3CCCCC3)cccc2c1	10.1016/j.bmc.2018.04.023
		CHEMBL4126145	161371	7	None	-42	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hrDisplacement of [3H]-5-carboxyamidotryptamine from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr	ChEMBL	297	7	0	2	4.9	c1ccc2c(OCCCCCN3CCCCC3)cccc2c1	10.1016/j.bmc.2018.04.023
		155561581	175640	0	None	-9	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	364	4	1	6	-0.3	CN1CCN(c2nc(N)nc(C[Se]c3ccccc3)n2)CC1	10.1016/j.ejmech.2019.06.022
		CHEMBL4580959	175640	0	None	-9	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	364	4	1	6	-0.3	CN1CCN(c2nc(N)nc(C[Se]c3ccccc3)n2)CC1	10.1016/j.ejmech.2019.06.022
		122483222	138107	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	391	6	0	4	4.2	CC(=O)N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3764889	138107	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	391	6	0	4	4.2	CC(=O)N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3765872	138107	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	391	6	0	4	4.2	CC(=O)N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		127028154	138257	0	None	7	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	444	6	2	5	1.9	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3F)CC2)C1=O	10.1016/j.ejmech.2016.02.024
		CHEMBL3770473	138257	0	None	7	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	444	6	2	5	1.9	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3F)CC2)C1=O	10.1016/j.ejmech.2016.02.024
		168295269	192512	0	None	-12	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	463	7	0	8	3.3	COc1cccc(N2CCN(CC3CCN(c4ncnc5cc(OC)c(OC)cc45)C3)CC2)c1	10.1016/j.ejmech.2022.114218
		CHEMBL5209272	192512	0	None	-12	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	463	7	0	8	3.3	COc1cccc(N2CCN(CC3CCN(c4ncnc5cc(OC)c(OC)cc45)C3)CC2)c1	10.1016/j.ejmech.2022.114218
		162653993	183668	0	None	-15	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3cccnc3)CC2)cc1	10.1016/j.bmc.2020.115943
		CHEMBL4753809	183668	0	None	-15	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3cccnc3)CC2)cc1	10.1016/j.bmc.2020.115943
		CHEMBL4802865	183668	0	None	-15	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3cccnc3)CC2)cc1	10.1016/j.bmc.2020.115943
		122483222	138107	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	391	6	0	4	4.2	CC(=O)N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3764889	138107	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	391	6	0	4	4.2	CC(=O)N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3765872	138107	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	391	6	0	4	4.2	CC(=O)N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		57390336	68419	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	401	10	1	4	2.9	NCCCN(CCCCN1CCc2ccccc2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2011.09.044
		CHEMBL1917340	68419	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	401	10	1	4	2.9	NCCCN(CCCCN1CCc2ccccc2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2011.09.044
		155514378	169850	0	None	-588	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting	ChEMBL	419	4	1	6	3.8	COc1ccc2c(c1)c(C1=CCNCC1)cn2S(=O)(=O)c1cccc2ncccc12	10.1021/acsmedchemlett.6b00056
		CHEMBL4440130	169850	0	None	-588	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting	ChEMBL	419	4	1	6	3.8	COc1ccc2c(c1)c(C1=CCNCC1)cn2S(=O)(=O)c1cccc2ncccc12	10.1021/acsmedchemlett.6b00056
		155559092	174789	0	None	-7	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	446	5	0	4	3.9	O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)N1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2016.06.080
		CHEMBL4561846	174789	0	None	-7	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	446	5	0	4	3.9	O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)N1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2016.06.080
		71451456	81420	0	None	-31	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	386	8	1	4	3.5	CCOc1ccccc1C(=O)NC1CCN(CCOc2cccc(F)c2)CC1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159463	81420	0	None	-31	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	386	8	1	4	3.5	CCOc1ccccc1C(=O)NC1CCN(CCOc2cccc(F)c2)CC1	10.1016/j.ejmech.2012.07.043
		59757163	106342	0	None	-218	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1cccc2c1Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
		CHEMBL3092760	106342	0	None	-218	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1cccc2c1Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
		CHEMBL3139189	106342	0	None	-218	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1cccc2c1Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
		145985289	165707	0	None	-3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	534	6	0	6	5.6	O=S(=O)(c1cncc2ccccc12)N1CCCCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4245607	165707	0	None	-3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	534	6	0	6	5.6	O=S(=O)(c1cncc2ccccc12)N1CCCCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
		127037680	136893	0	None	19	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	442	8	1	5	4.3	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(Cl)s2)CC1	10.1039/C5MD00166H
		CHEMBL3742257	136893	0	None	19	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	442	8	1	5	4.3	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(Cl)s2)CC1	10.1039/C5MD00166H
		66801429	159727	0	None	2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	443	6	2	3	4.5	Cc1cccc(S(=O)(=O)NCCN2CC=C(c3c(C)[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
		CHEMBL4104596	159727	0	None	2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	443	6	2	3	4.5	Cc1cccc(S(=O)(=O)NCCN2CC=C(c3c(C)[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
		44408813	75023	0	None	29	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	381	8	0	5	3.3	CCOC(=O)[C@@H]1CCCN(CCCC(C)(C)S(=O)(=O)c2ccccc2)C1	10.1016/j.bmcl.2005.11.067
		CHEMBL203400	75023	0	None	29	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	381	8	0	5	3.3	CCOC(=O)[C@@H]1CCCN(CCCC(C)(C)S(=O)(=O)c2ccccc2)C1	10.1016/j.bmcl.2005.11.067
		118709740	113532	0	None	23	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	348	7	0	2	4.2	O=C1Cc2ccccc2N1CCCCCCN1CCc2ccccc2C1	10.1021/jm500880c
		CHEMBL3321778	113532	0	None	23	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	348	7	0	2	4.2	O=C1Cc2ccccc2N1CCCCCCN1CCc2ccccc2C1	10.1021/jm500880c
		122178700	121305	0	None	2	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	411	8	0	5	5.0	CCCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
		CHEMBL3580670	121305	0	None	2	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	411	8	0	5	5.0	CCCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
		122178705	121371	0	None	-2	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	411	7	0	5	5.0	CCCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
		CHEMBL3581250	121371	0	None	-2	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	411	7	0	5	5.0	CCCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
		11384146	201733	0	None	-60	9	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cellsInhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	403	5	2	3	4.3	CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3cccc(Cl)c3)cc12	10.1021/jm049243i
		CHEMBL606556	201733	0	None	-60	9	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cellsInhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	403	5	2	3	4.3	CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3cccc(Cl)c3)cc12	10.1021/jm049243i
		155566508	175804	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	422	7	0	5	2.6	COc1ccccc1N1CCN(C(=O)CCN2CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2016.06.080
		CHEMBL4584464	175804	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	422	7	0	5	2.6	COc1ccccc1N1CCN(C(=O)CCN2CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2016.06.080
		164611932	185202	0	None	-5	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	364	6	1	4	3.1	O=C1CCc2cc(CCCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
		CHEMBL4857597	185202	0	None	-5	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	364	6	1	4	3.1	O=C1CCc2cc(CCCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
		9996500	18369	1	None	-10	3	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]lysergide from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]lysergide from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assay	ChEMBL	326	6	0	4	3.1	COc1cccc(CCN2CCN(c3ccccc3OC)CC2)c1	10.1021/acs.jmedchem.7b01898
		CHEMBL1271151	18369	1	None	-10	3	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]lysergide from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]lysergide from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assay	ChEMBL	326	6	0	4	3.1	COc1cccc(CCN2CCN(c3ccccc3OC)CC2)c1	10.1021/acs.jmedchem.7b01898
		136152964	194939	0	None	-8	8	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	259	2	2	3	2.8	C[C@@H]1NC(NCC(F)F)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.078
		CHEMBL541993	194939	0	None	-8	8	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	259	2	2	3	2.8	C[C@@H]1NC(NCC(F)F)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.078
		118524964	178135	0	None	-2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	243	2	0	1	3.8	CN(C)C1CCc2c(cccc2C2CCCC2)C1	10.1016/j.bmc.2019.115262
		CHEMBL4648489	178135	0	None	-2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	243	2	0	1	3.8	CN(C)C1CCc2c(cccc2C2CCCC2)C1	10.1016/j.bmc.2019.115262
		66801561	156077	0	None	-794	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	477	8	2	3	5.3	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
		CHEMBL4062817	156077	0	None	-794	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	477	8	2	3	5.3	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
		9856041	24114	3	None	-6606	8	Human	4.6	pKi	=	4.6	Binding	Inhibitory constant against human 5-hydroxytryptamine 7 receptor using [3H]LSD radioligandInhibitory constant against human 5-hydroxytryptamine 7 receptor using [3H]LSD radioligand	ChEMBL	230	2	2	2	2.4	CC(N)Cc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm030205t
		CHEMBL133868	24114	3	None	-6606	8	Human	4.6	pKi	=	4.6	Binding	Inhibitory constant against human 5-hydroxytryptamine 7 receptor using [3H]LSD radioligandInhibitory constant against human 5-hydroxytryptamine 7 receptor using [3H]LSD radioligand	ChEMBL	230	2	2	2	2.4	CC(N)Cc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm030205t
		60165545	75355	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	336	6	0	4	4.7	O=C(CCCCN1Cc2ccccc2C1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
		CHEMBL2037527	75355	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	336	6	0	4	4.7	O=C(CCCCN1Cc2ccccc2C1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
		90656707	110993	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	400	7	1	3	5.3	CN(CCCN1CCC(c2ccccc2)(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262426	110993	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	400	7	1	3	5.3	CN(CCCN1CCC(c2ccccc2)(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		168292233	191860	0	None	-34	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	8	0	6	4.2	O=c1n(CCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
		CHEMBL5199228	191860	0	None	-34	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	8	0	6	4.2	O=c1n(CCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
		1346	83	117	None	-147	9	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells	ChEMBL	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	10.1021/jm3003679
		280	83	117	None	-147	9	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells	ChEMBL	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	10.1021/jm3003679
		9899402	83	117	None	-147	9	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells	ChEMBL	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	10.1021/jm3003679
		CHEMBL9666	83	117	None	-147	9	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells	ChEMBL	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	10.1021/jm3003679
		42618263	182489	1	None	-9	2	Human	6.6	pKi	=	6.6	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	336	5	1	4	2.5	O=c1[nH]c2ccccc2n1CCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2009.02.008
		CHEMBL478682	182489	1	None	-9	2	Human	6.6	pKi	=	6.6	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	336	5	1	4	2.5	O=c1[nH]c2ccccc2n1CCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2009.02.008
		155534184	171942	0	None	-162	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	514	7	1	5	5.3	O=c1c(-c2ccccc2F)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
		CHEMBL4470437	171942	0	None	-162	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	514	7	1	5	5.3	O=c1c(-c2ccccc2F)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
		71457690	83798	0	None	-2	5	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	280	3	1	3	1.4	OC12C3C4CC5C6C4C1C6C(C53)N2CCc1cccnc1	10.1016/j.bmcl.2012.08.046
		CHEMBL2205817	83798	0	None	-2	5	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	280	3	1	3	1.4	OC12C3C4CC5C6C4C1C6C(C53)N2CCc1cccnc1	10.1016/j.bmcl.2012.08.046
		145965668	164114	0	None	1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	410	4	1	4	3.1	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccccc3Cl)CC1)C2	10.1016/j.bmcl.2018.06.019
		CHEMBL4209807	164114	0	None	1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	410	4	1	4	3.1	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccccc3Cl)CC1)C2	10.1016/j.bmcl.2018.06.019
		162650396	180085	0	None	-12	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	469	7	1	5	4.6	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2cc(Cl)ccc2c1	10.1016/j.ejmech.2020.112149
		CHEMBL4748107	180085	0	None	-12	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	469	7	1	5	4.6	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2cc(Cl)ccc2c1	10.1016/j.ejmech.2020.112149
		155542237	173090	0	None	-117	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	472	7	2	6	5.2	COc1ccc2c(c1)c(-c1[nH]c(NCc3ccccc3)nc1C)cn2S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2019.06.001
		CHEMBL4520003	173090	0	None	-117	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	472	7	2	6	5.2	COc1ccc2c(c1)c(-c1[nH]c(NCc3ccccc3)nc1C)cn2S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2019.06.001
		155514576	176550	0	None	-245	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	338	3	2	5	2.9	Nc1ncc(-c2cn(S(=O)(=O)c3ccccc3)c3ccccc23)[nH]1	10.1016/j.ejmech.2019.06.001
		CHEMBL4441060	176550	0	None	-245	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	338	3	2	5	2.9	Nc1ncc(-c2cn(S(=O)(=O)c3ccccc3)c3ccccc23)[nH]1	10.1016/j.ejmech.2019.06.001
		CHEMBL4597227	176550	0	None	-245	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	338	3	2	5	2.9	Nc1ncc(-c2cn(S(=O)(=O)c3ccccc3)c3ccccc23)[nH]1	10.1016/j.ejmech.2019.06.001
		60165543	75347	0	None	-47	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	367	6	0	7	2.9	O=C(CCCN1CCN(c2ncccn2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
		CHEMBL2037519	75347	0	None	-47	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	367	6	0	7	2.9	O=C(CCCN1CCN(c2ncccn2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
		4407909	192866	1	None	-4	10	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
		CHEMBL5182943	192866	1	None	-4	10	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
		CHEMBL5221893	192866	1	None	-4	10	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
		58404615	124556	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2ccc(C)c(C)c2)cc1OC1CNC1	nan
		CHEMBL3640563	124556	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2ccc(C)c(C)c2)cc1OC1CNC1	nan
		58404615	124556	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2ccc(C)c(C)c2)cc1OC1CNC1	nan
		CHEMBL3640563	124556	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2ccc(C)c(C)c2)cc1OC1CNC1	nan
		CHEMBL5084249	214905	0	None	-3	8	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCN(CC)CCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		134144864	150688	0	None	6	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	600	15	1	7	5.1	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(OCCN4CCOCC4)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		CHEMBL3955917	150688	0	None	6	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	600	15	1	7	5.1	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(OCCN4CCOCC4)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		155540807	172516	0	None	-3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	498	8	2	4	5.2	COc1ccc2[nH]cc(C3CC(=O)N(CCCCN4CCC(c5c[nH]c6ccccc56)CC4)C3=O)c2c1	10.1016/j.ejmech.2019.111736
		CHEMBL4483554	172516	0	None	-3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	498	8	2	4	5.2	COc1ccc2[nH]cc(C3CC(=O)N(CCCCN4CCC(c5c[nH]c6ccccc56)CC4)C3=O)c2c1	10.1016/j.ejmech.2019.111736
		2756712	81808	87	None	2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	238	2	1	2	2.8	c1ccc(-c2cccc(N3CCNCC3)c2)cc1	10.1021/jm3003679
		CHEMBL2164331	81808	87	None	2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	238	2	1	2	2.8	c1ccc(-c2cccc(N3CCNCC3)c2)cc1	10.1021/jm3003679
		135398737	958	93	None	-13	89	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2014.01.065
		38	958	93	None	-13	89	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2014.01.065
		722	958	93	None	-13	89	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2014.01.065
		CHEMBL42	958	93	None	-13	89	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2014.01.065
		DB00363	958	93	None	-13	89	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2014.01.065
		155517162	170141	0	None	-16	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	432	6	1	2	6.4	Fc1ccc(OCCN2CCC(c3c[nH]c4ccc(F)cc34)CC2)c(-c2ccccc2)c1	10.1016/j.bmcl.2019.126769
		CHEMBL4444213	170141	0	None	-16	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	432	6	1	2	6.4	Fc1ccc(OCCN2CCC(c3c[nH]c4ccc(F)cc34)CC2)c(-c2ccccc2)c1	10.1016/j.bmcl.2019.126769
		134154069	154447	0	None	-1	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1ccc2sc(CCCCN3CCc4ccccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
		CHEMBL3970299	154447	0	None	-1	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1ccc2sc(CCCCN3CCc4ccccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
		CHEMBL3990113	154447	0	None	-1	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1ccc2sc(CCCCN3CCc4ccccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
		57395086	71553	0	None	2	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cccc2cccnc12	10.1016/j.bmc.2011.12.039
		CHEMBL1949966	71553	0	None	2	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cccc2cccnc12	10.1016/j.bmc.2011.12.039
		CHEMBL1963029	71553	0	None	2	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cccc2cccnc12	10.1016/j.bmc.2011.12.039
		2220	3134	82	None	-3	14	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1016/j.bmc.2013.10.010
		27400	3134	82	None	-3	14	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1016/j.bmc.2013.10.010
		93	3134	82	None	-3	14	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1016/j.bmc.2013.10.010
		CHEMBL294951	3134	82	None	-3	14	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1016/j.bmc.2013.10.010
		DB06153	3134	82	None	-3	14	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1016/j.bmc.2013.10.010
		11582132	66011	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	401	6	1	3	4.5	O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm200547z
		CHEMBL1836860	66011	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	401	6	1	3	4.5	O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm200547z
		66800823	112066	0	None	-3	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	504	7	1	7	4.4	Cc1c(S(=O)(=O)NCCCN2CCN(c3nsc4ccccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
		CHEMBL3289961	112066	0	None	-3	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	504	7	1	7	4.4	Cc1c(S(=O)(=O)NCCCN2CCN(c3nsc4ccccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
		23661594	90625	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	664	16	0	8	6.3	COc1ccccc1N1CCN(CCc2cccc(OCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		CHEMBL238808	90625	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	664	16	0	8	6.3	COc1ccccc1N1CCN(CCc2cccc(OCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		162670445	182874	0	None	10	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	460	10	0	6	5.2	COc1ccc(-c2ccccc2N2CCN(CCC(C)(C)CCOc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
		CHEMBL4791805	182874	0	None	10	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	460	10	0	6	5.2	COc1ccc(-c2ccccc2N2CCN(CCC(C)(C)CCOc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
		44266267	207794	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	363	5	0	3	4.8	O=C1c2ccccc2CCCC1CCN1CCC(Oc2ccccc2)CC1	10.1016/s0960-894x(03)00077-5
		CHEMBL9615	207794	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	363	5	0	3	4.8	O=C1c2ccccc2CCCC1CCN1CCC(Oc2ccccc2)CC1	10.1016/s0960-894x(03)00077-5
		49850672	56386	0	None	-100	9	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	404	5	1	5	4.1	COC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
		CHEMBL1631532	56386	0	None	-100	9	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	404	5	1	5	4.1	COC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
		11729084	204196	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	400	6	0	2	5.2	CN1C(=O)C2(CCCCN3CC=C(c4ccccc4)CC3)CCCc3cccc1c32	10.1021/jm0104264
		CHEMBL70819	204196	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	400	6	0	2	5.2	CN1C(=O)C2(CCCCN3CC=C(c4ccccc4)CC3)CCCc3cccc1c32	10.1021/jm0104264
		10593348	97295	0	None	4	4	Rat	7.6	pKi	=	7.6	Binding	Binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligandBinding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligand	ChEMBL	341	1	1	2	5.1	Cc1cccc(O)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm030841r
		CHEMBL26907	97295	0	None	4	4	Rat	7.6	pKi	=	7.6	Binding	Binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligandBinding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligand	ChEMBL	341	1	1	2	5.1	Cc1cccc(O)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm030841r
		CHEMBL5084249	214905	0	None	-3	8	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCN(CC)CCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		117209962	184869	1	None	4	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	242	2	2	3	1.8	Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4852622	184869	1	None	4	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	242	2	2	3	1.8	Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		134154069	154447	0	None	-1	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1ccc2sc(CCCCN3CCc4ccccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
		CHEMBL3970299	154447	0	None	-1	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1ccc2sc(CCCCN3CCc4ccccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
		CHEMBL3990113	154447	0	None	-1	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1ccc2sc(CCCCN3CCc4ccccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
		162654406	180580	0	None	-63	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	459	7	1	6	4.2	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(F)cc2s1	10.1016/j.ejmech.2020.112149
		CHEMBL4754193	180580	0	None	-63	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	459	7	1	6	4.2	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(F)cc2s1	10.1016/j.ejmech.2020.112149
		179	400	115	None	-9	49	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1021/jm070516u
		2159	400	115	None	-9	49	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1021/jm070516u
		963	400	115	None	-9	49	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1021/jm070516u
		CHEMBL243712	400	115	None	-9	49	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1021/jm070516u
		DB06288	400	115	None	-9	49	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1021/jm070516u
		168293874	192179	0	None	-5	11	Human	7.6	pKi	=	7.6	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
		CHEMBL5204071	192179	0	None	-5	11	Human	7.6	pKi	=	7.6	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
		24854186	95781	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	407	8	1	4	4.3	CCC1(CCCCN2CCN(c3ccc(OC)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		CHEMBL258593	95781	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	407	8	1	4	4.3	CCC1(CCCCN2CCN(c3ccc(OC)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		24768520	93007	0	None	-1	4	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	434	9	2	4	4.6	CNc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
		CHEMBL244161	93007	0	None	-1	4	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	434	9	2	4	4.6	CNc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
		46204422	124562	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	293	3	1	2	3.7	FC(F)(F)c1ccccc1-c1cccc(OC2CNC2)c1	nan
		CHEMBL3640569	124562	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	293	3	1	2	3.7	FC(F)(F)c1ccccc1-c1cccc(OC2CNC2)c1	nan
		46204422	124562	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	293	3	1	2	3.7	FC(F)(F)c1ccccc1-c1cccc(OC2CNC2)c1	nan
		CHEMBL3640569	124562	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	293	3	1	2	3.7	FC(F)(F)c1ccccc1-c1cccc(OC2CNC2)c1	nan
		134134456	143344	0	None	20	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	514	11	1	5	5.4	COc1ccc(-c2cc(F)ccc2N2CCN(CCCCCC(=O)NCc3ccc(C#N)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		CHEMBL3897426	143344	0	None	20	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	514	11	1	5	5.4	COc1ccc(-c2cc(F)ccc2N2CCN(CCCCCC(=O)NCc3ccc(C#N)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		44341130	9648	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	377	5	1	5	2.2	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3[nH]nnc3c2)CC1	10.1016/s0960-894x(02)00690-x
		CHEMBL112765	9648	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	377	5	1	5	2.2	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3[nH]nnc3c2)CC1	10.1016/s0960-894x(02)00690-x
		162674732	183385	0	None	48	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	534	9	1	7	5.2	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccc(-c4cn5ccccc5n4)cc3)CC2)cc1	10.1016/j.ejmech.2020.112395
		CHEMBL4797980	183385	0	None	48	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	534	9	1	7	5.2	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccc(-c4cn5ccccc5n4)cc3)CC2)cc1	10.1016/j.ejmech.2020.112395
		162651486	180269	0	None	-3	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	437	7	1	5	3.6	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)c(Cl)c1	10.1016/j.ejmech.2020.112149
		CHEMBL4750587	180269	0	None	-3	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	437	7	1	5	3.6	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)c(Cl)c1	10.1016/j.ejmech.2020.112149
		10805599	99216	0	None	-13	3	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	319	3	0	2	4.4	CCO[C@]1(CC)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
		CHEMBL281554	99216	0	None	-13	3	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	319	3	0	2	4.4	CCO[C@]1(CC)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
		72550865	114080	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	491	10	1	4	5.6	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2014.07.026
		CHEMBL3326984	114080	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	491	10	1	4	5.6	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2014.07.026
		53318219	57027	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	350	4	0	2	5.2	CCN1CCc2c(c(-c3ccc(Cl)cc3)cn2Cc2ccccc2)C1	10.1016/j.bmcl.2010.11.078
		CHEMBL1644489	57027	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	350	4	0	2	5.2	CCN1CCc2c(c(-c3ccc(Cl)cc3)cn2Cc2ccccc2)C1	10.1016/j.bmcl.2010.11.078
		42625356	186999	0	None	-21	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	397	5	0	3	4.1	O=C1Cc2ccccc2N1C/C=C\CN1CCN(c2cccc3ccccc23)CC1	10.1021/jm8014553
		CHEMBL490644	186999	0	None	-21	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	397	5	0	3	4.1	O=C1Cc2ccccc2N1C/C=C\CN1CCN(c2cccc3ccccc23)CC1	10.1021/jm8014553
		66801267	112085	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	484	7	1	6	4.1	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
		CHEMBL3289979	112085	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	484	7	1	6	4.1	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
		42618259	189734	0	None	-13	2	Human	5.6	pKi	=	5.6	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	442	6	0	6	3.9	COc1cccc(-n2c(=O)n(CCN3CCN(c4ccccc4C)CC3)c3ccccc32)c1	10.1016/j.bmcl.2009.02.008
		CHEMBL515783	189734	0	None	-13	2	Human	5.6	pKi	=	5.6	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	442	6	0	6	3.9	COc1cccc(-n2c(=O)n(CCN3CCN(c4ccccc4C)CC3)c3ccccc32)c1	10.1016/j.bmcl.2009.02.008
		44439401	91783	0	None	-12	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	395	4	0	5	3.6	COC(=O)N1CCc2ccc(/N=C/N3CCc4cc(OC)c(OC)cc4C3)cc21	10.1016/j.bmcl.2007.01.093
		CHEMBL241101	91783	0	None	-12	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	395	4	0	5	3.6	COC(=O)N1CCc2ccc(/N=C/N3CCc4cc(OC)c(OC)cc4C3)cc21	10.1016/j.bmcl.2007.01.093
		11294248	167737	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)	ChEMBL	465	8	0	5	4.4	COc1ccccc1N1CCN(CCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL430280	167737	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)	ChEMBL	465	8	0	5	4.4	COc1ccccc1N1CCN(CCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/j.bmc.2019.06.028
		44401243	168494	0	None	-104	9	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.6	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL435301	168494	0	None	-104	9	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.6	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
		11294248	167737	0	None	-1	2	Rat	6.6	pKi	=	6.6	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	465	8	0	5	4.4	COc1ccccc1N1CCN(CCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/s0960-894x(00)00166-9
		CHEMBL430280	167737	0	None	-1	2	Rat	6.6	pKi	=	6.6	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	465	8	0	5	4.4	COc1ccccc1N1CCN(CCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/s0960-894x(00)00166-9
		11294248	167737	0	None	-1	2	Rat	6.6	pKi	=	6.6	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	465	8	0	5	4.4	COc1ccccc1N1CCN(CCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1021/jm030841r
		CHEMBL430280	167737	0	None	-1	2	Rat	6.6	pKi	=	6.6	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	465	8	0	5	4.4	COc1ccccc1N1CCN(CCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1021/jm030841r
		168283304	191285	0	None	-7	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	433	6	0	7	3.3	COc1cc2ncnc(N3CCC(CN4CCN(c5ccccc5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
		CHEMBL5190746	191285	0	None	-7	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	433	6	0	7	3.3	COc1cc2ncnc(N3CCC(CN4CCN(c5ccccc5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
		142601323	185841	0	None	9	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1ccccc1-c1n[nH]cc1N1CCCNCC1	10.1021/acs.jmedchem.1c01093
		CHEMBL4867560	185841	0	None	9	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1ccccc1-c1n[nH]cc1N1CCCNCC1	10.1021/acs.jmedchem.1c01093
		122483235	138101	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	438	8	0	3	7.0	O=C(CCCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3763329	138101	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	438	8	0	3	7.0	O=C(CCCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765849	138101	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	438	8	0	3	7.0	O=C(CCCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		9890119	208057	0	None	-2511	7	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligand	ChEMBL	452	4	2	5	4.3	O=S(=O)(Nc1ccc2nccc(N3CCNCC3)c2c1)c1ccc2c(Cl)cccc2c1	10.1016/s0960-894x(01)00558-3
		CHEMBL97596	208057	0	None	-2511	7	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligand	ChEMBL	452	4	2	5	4.3	O=S(=O)(Nc1ccc2nccc(N3CCNCC3)c2c1)c1ccc2c(Cl)cccc2c1	10.1016/s0960-894x(01)00558-3
		6918647	100746	2	None	-501	14	Human	5.6	pKi	=	5.6	Binding	Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT	ChEMBL	439	5	1	5	3.0	COc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1N1CCN(C)CC1	10.1021/jm980532e
		CHEMBL292759	100746	2	None	-501	14	Human	5.6	pKi	=	5.6	Binding	Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT	ChEMBL	439	5	1	5	3.0	COc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1N1CCN(C)CC1	10.1021/jm980532e
		155534795	176251	0	None	-316	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	402	3	2	5	4.3	Cc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2cccc3ccccc23)c2ccccc12	10.1016/j.ejmech.2019.06.001
		CHEMBL4471055	176251	0	None	-316	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	402	3	2	5	4.3	Cc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2cccc3ccccc23)c2ccccc12	10.1016/j.ejmech.2019.06.001
		CHEMBL4594879	176251	0	None	-316	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	402	3	2	5	4.3	Cc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2cccc3ccccc23)c2ccccc12	10.1016/j.ejmech.2019.06.001
		155534575	171946	0	None	-12	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	429	8	0	7	2.0	O=C1c2ccccc2S(=O)(=O)N1CCCCCCN1CCN(c2ncccn2)CC1	10.1016/j.bmcl.2021.128028
		CHEMBL4470487	171946	0	None	-12	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	429	8	0	7	2.0	O=C1c2ccccc2S(=O)(=O)N1CCCCCCN1CCN(c2ncccn2)CC1	10.1016/j.bmcl.2021.128028
		142601323	185841	0	None	9	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1ccccc1-c1n[nH]cc1N1CCCNCC1	10.1021/acs.jmedchem.1c01093
		CHEMBL4867560	185841	0	None	9	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1ccccc1-c1n[nH]cc1N1CCCNCC1	10.1021/acs.jmedchem.1c01093
		122483235	138101	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	438	8	0	3	7.0	O=C(CCCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3763329	138101	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	438	8	0	3	7.0	O=C(CCCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765849	138101	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	438	8	0	3	7.0	O=C(CCCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		90656675	110973	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	297	5	2	4	2.6	Oc1cccc(NCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262404	110973	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	297	5	2	4	2.6	Oc1cccc(NCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
		44437333	91754	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	791	25	0	8	9.8	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		CHEMBL240944	91754	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	791	25	0	8	9.8	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		1296368	50821	16	None	-1	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	458	5	2	5	6.0	O=S(=O)(Nc1cc(Sc2cccc3cccnc23)c(O)c2ccccc12)c1ccccc1	10.1016/j.bmcl.2015.03.049
		CHEMBL1576791	50821	16	None	-1	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	458	5	2	5	6.0	O=S(=O)(Nc1cc(Sc2cccc3cccnc23)c(O)c2ccccc12)c1ccccc1	10.1016/j.bmcl.2015.03.049
		134152583	153177	0	None	10	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	530	10	1	5	4.8	O=C(CCOCCN1CCN(c2cccnc2-c2ccc(F)cc2)CC1)NCc1ccc(C(F)(F)F)cc1	10.1016/j.ejmech.2016.05.005
		CHEMBL3976948	153177	0	None	10	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	530	10	1	5	4.8	O=C(CCOCCN1CCN(c2cccnc2-c2ccc(F)cc2)CC1)NCc1ccc(C(F)(F)F)cc1	10.1016/j.ejmech.2016.05.005
		162670926	183753	0	None	-2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	397	9	2	5	3.7	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4790694	183753	0	None	-2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	397	9	2	5	3.7	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4803789	183753	0	None	-2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	397	9	2	5	3.7	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
		18133518	164711	1	None	14	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2ccc(Cl)cc2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
		CHEMBL4217334	164711	1	None	14	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2ccc(Cl)cc2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
		168284840	191296	0	None	-8	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	439	5	0	6	3.8	O=c1n(CC2CCC(CN3CCN(c4cccc(Cl)c4)CC3)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
		CHEMBL5190996	191296	0	None	-8	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	439	5	0	6	3.8	O=c1n(CC2CCC(CN3CCN(c4cccc(Cl)c4)CC3)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
		134141355	154585	0	None	-2	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.8	O=C(CCCN1CCCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
		CHEMBL3924565	154585	0	None	-2	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.8	O=C(CCCN1CCCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
		CHEMBL3991357	154585	0	None	-2	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.8	O=C(CCCN1CCCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
		134141355	154585	0	None	-2	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.8	O=C(CCCN1CCCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
		CHEMBL3924565	154585	0	None	-2	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.8	O=C(CCCN1CCCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
		CHEMBL3991357	154585	0	None	-2	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.8	O=C(CCCN1CCCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
		44324603	111473	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	252	2	2	4	2.4	Cc1c(NC2=NCCN2)cccc1-c1cccnc1	10.1016/s0960-894x(02)00925-3
		CHEMBL327654	111473	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	252	2	2	4	2.4	Cc1c(NC2=NCCN2)cccc1-c1cccnc1	10.1016/s0960-894x(02)00925-3
		145965401	164046	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	486	7	1	4	3.1	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccccc1I	10.1021/acs.jmedchem.8b00828
		CHEMBL4208911	164046	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	486	7	1	4	3.1	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccccc1I	10.1021/acs.jmedchem.8b00828
		44437332	91586	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	763	23	0	8	9.0	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		CHEMBL240729	91586	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	763	23	0	8	9.0	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		134142259	145585	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	501	13	2	5	4.7	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccc(OCCO)cc1	10.1016/j.ejmech.2016.05.005
		CHEMBL3915374	145585	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	501	13	2	5	4.7	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccc(OCCO)cc1	10.1016/j.ejmech.2016.05.005
		127027387	137842	0	None	15	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	451	8	2	5	3.8	Nc1ccc(S(=O)(=O)NC2CCN(CCOc3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2015.11.040
		CHEMBL3759948	137842	0	None	15	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	451	8	2	5	3.8	Nc1ccc(S(=O)(=O)NC2CCN(CCOc3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2015.11.040
		242	470	124	None	-15	51	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2012.11.042
		34	470	124	None	-15	51	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2012.11.042
		60795	470	124	None	-15	51	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2012.11.042
		CHEMBL1112	470	124	None	-15	51	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2012.11.042
		DB01238	470	124	None	-15	51	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2012.11.042
		25125376	177976	0	None	3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	285	2	0	1	4.4	CN(C)C1CCc2c(cccc2-c2cccc(Cl)c2)C1	10.1016/j.bmc.2019.115262
		CHEMBL4646015	177976	0	None	3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	285	2	0	1	4.4	CN(C)C1CCc2c(cccc2-c2cccc(Cl)c2)C1	10.1016/j.bmc.2019.115262
		4806	4008	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2019.126703
		4806	4008	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2019.126769
		7351	4008	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2019.126703
		7351	4008	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2019.126769
		9966051	4008	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2019.126703
		9966051	4008	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2019.126769
		CHEMBL2104993	4008	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2019.126703
		CHEMBL2104993	4008	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2019.126769
		DB09068	4008	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2019.126703
		DB09068	4008	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2019.126769
		54598063	154557	0	None	-37	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor after 60 mins by liquid scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor after 60 mins by liquid scintillation counting method	ChEMBL	354	7	0	4	3.9	COc1ccccc1N1CCN(CCCOc2c(C)cccc2C)CC1	10.1016/j.bmcl.2018.04.059
		CHEMBL3979261	154557	0	None	-37	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor after 60 mins by liquid scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor after 60 mins by liquid scintillation counting method	ChEMBL	354	7	0	4	3.9	COc1ccccc1N1CCN(CCCOc2c(C)cccc2C)CC1	10.1016/j.bmcl.2018.04.059
		CHEMBL3991129	154557	0	None	-37	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor after 60 mins by liquid scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor after 60 mins by liquid scintillation counting method	ChEMBL	354	7	0	4	3.9	COc1ccccc1N1CCN(CCCOc2c(C)cccc2C)CC1	10.1016/j.bmcl.2018.04.059
		4806	4008	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2017.11.007
		7351	4008	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2017.11.007
		9966051	4008	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2017.11.007
		CHEMBL2104993	4008	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2017.11.007
		DB09068	4008	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2017.11.007
		21048761	140306	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	397	7	0	3	5.0	O=S(=O)(c1ccccc1)C1(CCCN2CCC(c3ccccc3)CC2)CCC1	10.1016/j.bmcl.2005.11.067
		CHEMBL380613	140306	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	397	7	0	3	5.0	O=S(=O)(c1ccccc1)C1(CCCN2CCC(c3ccccc3)CC2)CCC1	10.1016/j.bmcl.2005.11.067
		424430	107629	5	None	60	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	292	3	2	2	3.6	COc1cccc(CC2NCCc3c2[nH]c2ccccc32)c1	10.1016/j.bmcl.2007.01.093
		CHEMBL319005	107629	5	None	60	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	292	3	2	2	3.6	COc1cccc(CC2NCCc3c2[nH]c2ccccc32)c1	10.1016/j.bmcl.2007.01.093
		46233352	200656	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	248	5	0	4	3.0	CN(C)CCSc1cccc(-c2ccoc2)n1	10.1016/j.bmc.2010.01.035
		CHEMBL599612	200656	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	248	5	0	4	3.0	CN(C)CCSc1cccc(-c2ccoc2)n1	10.1016/j.bmc.2010.01.035
		4806	4008	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.ejmech.2017.12.063
		7351	4008	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.ejmech.2017.12.063
		9966051	4008	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.ejmech.2017.12.063
		CHEMBL2104993	4008	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.ejmech.2017.12.063
		DB09068	4008	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.ejmech.2017.12.063
		23369421	181477	0	None	-4	2	Human	7.6	pKi	=	7.6	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	380	7	1	5	2.9	COc1ccccc1N1CCN(CCCCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
		CHEMBL476463	181477	0	None	-4	2	Human	7.6	pKi	=	7.6	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	380	7	1	5	2.9	COc1ccccc1N1CCN(CCCCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
		71061750	105014	0	None	23	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	473	11	1	6	4.2	COc1ccc(CNC(=O)CCCCCN2CCN(c3ncccc3-c3ccncc3)CC2)cc1	10.1016/j.bmc.2014.01.016
		CHEMBL3113603	105014	0	None	23	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	473	11	1	6	4.2	COc1ccc(CNC(=O)CCCCCN2CCN(c3ncccc3-c3ccncc3)CC2)cc1	10.1016/j.bmc.2014.01.016
		72548115	114085	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	471	10	1	4	5.3	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2C)CC1	10.1016/j.bmc.2014.07.026
		CHEMBL3326989	114085	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	471	10	1	4	5.3	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2C)CC1	10.1016/j.bmc.2014.07.026
		109027017	174400	2	None	10	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	378	5	0	4	2.5	O=C(CCN1CCN(c2ccccc2)CC1)N1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2016.06.080
		CHEMBL4552394	174400	2	None	10	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	378	5	0	4	2.5	O=C(CCN1CCN(c2ccccc2)CC1)N1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2016.06.080
		CHEMBL5080305	214677	0	None	-4	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		Cc1cccc(S(=O)(=O)CC2CCN(CCCc3noc4cc(F)ccc34)C2)c1	10.1021/acs.jmedchem.1c00497
		44324573	111529	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	285	2	2	3	3.7	Cc1c(NC2=NCCN2)cccc1-c1cccc(Cl)c1	10.1016/s0960-894x(02)00925-3
		CHEMBL327906	111529	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	285	2	2	3	3.7	Cc1c(NC2=NCCN2)cccc1-c1cccc(Cl)c1	10.1016/s0960-894x(02)00925-3
		10521887	114370	0	None	3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	351	6	0	5	3.2	O=c1oc2ccccc2n1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
		CHEMBL3331254	114370	0	None	3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	351	6	0	5	3.2	O=c1oc2ccccc2n1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
		162672029	182905	0	None	18	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	534	8	1	7	5.0	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3cc(Cl)c4oc(=O)cc(C)c4c3)CC2)cc1	10.1016/j.ejmech.2020.112395
		CHEMBL4792307	182905	0	None	18	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	534	8	1	7	5.0	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3cc(Cl)c4oc(=O)cc(C)c4c3)CC2)cc1	10.1016/j.ejmech.2020.112395
		11047201	52125	0	None	-1	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	382	9	1	5	4.0	COc1ccccc1N1CCN(CCCCCC(=O)c2cccc(O)c2)CC1	10.1021/jm020994z
		CHEMBL158770	52125	0	None	-1	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	382	9	1	5	4.0	COc1ccccc1N1CCN(CCCCCC(=O)c2cccc(O)c2)CC1	10.1021/jm020994z
		127051015	140874	0	None	5	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818128	140874	0	None	5	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3819731	140874	0	None	5	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		162673636	183773	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	11	1	4	5.5	CCC(C)c1ccc(NC(=O)CCCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.ejmech.2020.112437
		CHEMBL4796041	183773	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	11	1	4	5.5	CCC(C)c1ccc(NC(=O)CCCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.ejmech.2020.112437
		CHEMBL4803955	183773	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	11	1	4	5.5	CCC(C)c1ccc(NC(=O)CCCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.ejmech.2020.112437
		276	3513	50	None	-100	13	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptorDisplacement of [3H]LSD from human cloned 5HT7 receptor	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/j.bmcl.2007.11.045
		5312149	3513	50	None	-100	13	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptorDisplacement of [3H]LSD from human cloned 5HT7 receptor	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/j.bmcl.2007.11.045
		CHEMBL431298	3513	50	None	-100	13	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptorDisplacement of [3H]LSD from human cloned 5HT7 receptor	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/j.bmcl.2007.11.045
		156010187	177114	0	None	2	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	241	2	0	2	3.4	CN(C)[C@@H]1CCc2c(cccc2-c2ccco2)C1	10.1016/j.bmc.2019.115262
		CHEMBL4633600	177114	0	None	2	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	241	2	0	2	3.4	CN(C)[C@@H]1CCc2c(cccc2-c2ccco2)C1	10.1016/j.bmc.2019.115262
		20923078	117935	6	None	-1	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	387	4	2	5	3.2	O=c1ccc(-c2ccc(S(=O)(=O)Nc3cccc4c3CCCC4)s2)n[nH]1	10.1016/j.bmcl.2015.03.049
		CHEMBL3403339	117935	6	None	-1	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	387	4	2	5	3.2	O=c1ccc(-c2ccc(S(=O)(=O)Nc3cccc4c3CCCC4)s2)n[nH]1	10.1016/j.bmcl.2015.03.049
		1353	1911	93	None	-120	83	Rat	6.6	pKi	=	6.6	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030030n
		3559	1911	93	None	-120	83	Rat	6.6	pKi	=	6.6	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030030n
		86	1911	93	None	-120	83	Rat	6.6	pKi	=	6.6	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030030n
		CHEMBL54	1911	93	None	-120	83	Rat	6.6	pKi	=	6.6	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030030n
		DB00502	1911	93	None	-120	83	Rat	6.6	pKi	=	6.6	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030030n
		52952422	62592	0	None	12	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	391	5	1	5	4.4	N#Cc1ccc(N2CCCN(CCC(O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
		CHEMBL1782809	62592	0	None	12	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	391	5	1	5	4.4	N#Cc1ccc(N2CCCN(CCC(O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
		11329844	85159	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	447	9	1	4	4.8	CC(=O)c1ccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)cc1	10.1021/jm049702f
		CHEMBL225171	85159	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	447	9	1	4	4.8	CC(=O)c1ccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)cc1	10.1021/jm049702f
		127026144	137686	0	None	2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	415	7	2	3	5.1	CC(C)c1ccccc1OCCN1CCC(NC(=O)Nc2cccc(Cl)c2)CC1	10.1016/j.ejmech.2015.11.040
		CHEMBL3758684	137686	0	None	2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	415	7	2	3	5.1	CC(C)c1ccccc1OCCN1CCC(NC(=O)Nc2cccc(Cl)c2)CC1	10.1016/j.ejmech.2015.11.040
		1830	2590	44	None	-30	28	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1021/jm030030n
		207	2590	44	None	-30	28	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1021/jm030030n
		23897	2590	44	None	-30	28	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1021/jm030030n
		CHEMBL460	2590	44	None	-30	28	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1021/jm030030n
		DB01618	2590	44	None	-30	28	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1021/jm030030n
		134151428	154552	0	None	-10	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	291	3	0	2	3.5	O=C1c2ccccc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
		CHEMBL3978642	154552	0	None	-10	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	291	3	0	2	3.5	O=C1c2ccccc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
		CHEMBL3991094	154552	0	None	-10	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	291	3	0	2	3.5	O=C1c2ccccc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
		5216959	8610	4	None	-7	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	363	8	2	5	2.6	OC(CNCC1COc2ccccc2O1)COCc1ccccc1Cl	10.1016/j.bmcl.2010.03.012
		CHEMBL1094908	8610	4	None	-7	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	363	8	2	5	2.6	OC(CNCC1COc2ccccc2O1)COCc1ccccc1Cl	10.1016/j.bmcl.2010.03.012
		1816	2540	102	None	-165	18	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
		4205	2540	102	None	-165	18	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
		7241	2540	102	None	-165	18	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
		CHEMBL654	2540	102	None	-165	18	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
		DB00370	2540	102	None	-165	18	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
		155562202	175818	0	None	-26	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	471	9	0	5	4.8	COc1ccccc1N1CCN(CCCCCCN2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.bmcl.2019.06.029
		CHEMBL4584719	175818	0	None	-26	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	471	9	0	5	4.8	COc1ccccc1N1CCN(CCCCCCN2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.bmcl.2019.06.029
		888311	200682	46	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	243	4	0	2	2.4	CN(C)CCOc1ccccc1Br	10.1016/j.bmc.2010.01.035
		CHEMBL599818	200682	46	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	243	4	0	2	2.4	CN(C)CCOc1ccccc1Br	10.1016/j.bmc.2010.01.035
		22549784	117937	6	None	-2	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	418	4	0	4	4.9	COc1cccc(-n2cc(C(=O)N(C)c3cccc(Cl)c3)c3ccccc3c2=O)c1	10.1016/j.bmcl.2015.03.049
		CHEMBL3403340	117937	6	None	-2	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	418	4	0	4	4.9	COc1cccc(-n2cc(C(=O)N(C)c3cccc(Cl)c3)c3ccccc3c2=O)c1	10.1016/j.bmcl.2015.03.049
		57393876	68417	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	373	8	1	4	2.1	NCCN(CCCN1CCc2ccccc2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2011.09.044
		CHEMBL1917338	68417	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	373	8	1	4	2.1	NCCN(CCCN1CCc2ccccc2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2011.09.044
		155536631	172220	0	None	-6	7	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	339	4	0	3	3.5	Fc1ccc2c(c1)CC(CCN1CCCN(c3ccccn3)CC1)C2	10.1016/j.bmc.2020.115943
		CHEMBL4474014	172220	0	None	-6	7	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	339	4	0	3	3.5	Fc1ccc2c(c1)CC(CCN1CCCN(c3ccccn3)CC1)C2	10.1016/j.bmc.2020.115943
		162653993	183668	0	None	-15	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3cccnc3)CC2)cc1	10.1016/j.bmc.2020.115943
		CHEMBL4753809	183668	0	None	-15	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3cccnc3)CC2)cc1	10.1016/j.bmc.2020.115943
		CHEMBL4802865	183668	0	None	-15	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3cccnc3)CC2)cc1	10.1016/j.bmc.2020.115943
		44424657	85761	0	None	1	2	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	474	8	0	9	2.1	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2007.05.017
		CHEMBL229179	85761	0	None	1	2	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	474	8	0	9	2.1	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2007.05.017
		42618262	181571	0	None	-7	2	Human	6.6	pKi	=	6.6	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	486	9	0	7	4.4	COc1ccc(-n2c(=O)n(CCCCN3CCN(c4ccccc4OC)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2009.02.008
		CHEMBL476821	181571	0	None	-7	2	Human	6.6	pKi	=	6.6	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	486	9	0	7	4.4	COc1ccc(-n2c(=O)n(CCCCN3CCN(c4ccccc4OC)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2009.02.008
		164619936	186209	0	None	-446	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	415	7	0	7	1.6	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2ncccn2)CC1	10.1016/j.bmcl.2021.128028
		CHEMBL4873100	186209	0	None	-446	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	415	7	0	7	1.6	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2ncccn2)CC1	10.1016/j.bmcl.2021.128028
		71462064	81162	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	8	1	3	5.2	Cc1ccccc1C(=O)NCC1CCN(CCOc2cccc(-c3ccccc3)c2)CC1	10.1016/j.ejmech.2012.07.043
		CHEMBL2158028	81162	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	8	1	3	5.2	Cc1ccccc1C(=O)NCC1CCN(CCOc2cccc(-c3ccccc3)c2)CC1	10.1016/j.ejmech.2012.07.043
		10740969	99086	0	None	-3	4	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	423	7	1	5	3.4	COc1ccccc1N1CCN(CCC(=O)NC2CCCc3c(OC)cccc32)CC1	10.1021/jm049702f
		CHEMBL28063	99086	0	None	-3	4	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	423	7	1	5	3.4	COc1ccccc1N1CCN(CCC(=O)NC2CCCc3c(OC)cccc32)CC1	10.1021/jm049702f
		155536631	172220	0	None	-6	7	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	339	4	0	3	3.5	Fc1ccc2c(c1)CC(CCN1CCCN(c3ccccn3)CC1)C2	10.1016/j.bmc.2020.115943
		CHEMBL4474014	172220	0	None	-6	7	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	339	4	0	3	3.5	Fc1ccc2c(c1)CC(CCN1CCCN(c3ccccn3)CC1)C2	10.1016/j.bmc.2020.115943
		452533	120014	5	None	3	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	265	5	0	5	2.9	CN(C)CCSc1nc(-c2ccncc2)cs1	10.1016/j.bmcl.2003.11.050
		CHEMBL350166	120014	5	None	3	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	265	5	0	5	2.9	CN(C)CCSc1nc(-c2ccncc2)cs1	10.1016/j.bmcl.2003.11.050
		122181252	121856	0	None	-2	3	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	452	6	1	4	3.6	O=C1NC2(CCc3ccccc32)C(=O)N1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2015.04.026
		CHEMBL3589978	121856	0	None	-2	3	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	452	6	1	4	3.6	O=C1NC2(CCc3ccccc32)C(=O)N1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2015.04.026
		76325349	106417	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	383	4	1	4	4.7	Oc1ccccc1N1CCN(Cc2cn(-c3ccccc3)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
		CHEMBL3121436	106417	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	383	4	1	4	4.7	Oc1ccccc1N1CCN(Cc2cn(-c3ccccc3)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
		CHEMBL3139519	106417	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	383	4	1	4	4.7	Oc1ccccc1N1CCN(Cc2cn(-c3ccccc3)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
		127026120	137806	0	None	7	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	436	9	1	5	3.4	CC(C)Oc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
		CHEMBL3759651	137806	0	None	7	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	436	9	1	5	3.4	CC(C)Oc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
		134131976	144975	0	None	34	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	509	10	1	5	5.2	N#Cc1ccc(CNC(=O)CCCCCN2CCN(c3ccc(F)cc3-c3ccc(C#N)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		CHEMBL3910730	144975	0	None	34	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	509	10	1	5	5.2	N#Cc1ccc(CNC(=O)CCCCCN2CCN(c3ccc(F)cc3-c3ccc(C#N)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		71449549	81167	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	476	11	1	6	3.9	COc1ccc(OC)c(S(=O)(=O)NCC2CCN(CCOc3ccccc3C(C)C)CC2)c1	10.1016/j.ejmech.2012.07.043
		CHEMBL2158033	81167	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	476	11	1	6	3.9	COc1ccc(OC)c(S(=O)(=O)NCC2CCN(CCOc3ccccc3C(C)C)CC2)c1	10.1016/j.ejmech.2012.07.043
		71462179	81429	0	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	406	7	1	5	3.1	O=S(=O)(NC1CCN(CCOc2cccc3c2CCCC3)C1)c1cccs1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159472	81429	0	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	406	7	1	5	3.1	O=S(=O)(NC1CCN(CCOc2cccc3c2CCCC3)C1)c1cccs1	10.1016/j.ejmech.2012.07.043
		71574304	86265	0	None	1	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc2cccnc12	10.1016/j.ejmech.2012.11.042
		CHEMBL2312638	86265	0	None	1	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc2cccnc12	10.1016/j.ejmech.2012.11.042
		117209962	184869	1	None	4	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	242	2	2	3	1.8	Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4852622	184869	1	None	4	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	242	2	2	3	1.8	Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		156020705	178077	0	None	4	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	328	2	1	3	2.8	CN1CCc2cccc3c2C1Cc1ccc(NS(C)(=O)=O)cc1-3	10.1016/j.bmc.2020.115578
		CHEMBL4647589	178077	0	None	4	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	328	2	1	3	2.8	CN1CCc2cccc3c2C1Cc1ccc(NS(C)(=O)=O)cc1-3	10.1016/j.bmc.2020.115578
		2726	919	68	None	-13	72	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2011.08.033
		621	919	68	None	-13	72	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2011.08.033
		83	919	68	None	-13	72	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2011.08.033
		CHEMBL71	919	68	None	-13	72	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2011.08.033
		DB00477	919	68	None	-13	72	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2011.08.033
		127051015	140874	0	None	5	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818128	140874	0	None	5	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3819731	140874	0	None	5	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		9865858	163305	0	None	-16	8	Rat	7.6	pKi	=	7.6	Binding	The compound was tested for binding affinity against 5-hydroxytryptamine 7 receptorThe compound was tested for binding affinity against 5-hydroxytryptamine 7 receptor	ChEMBL	402	6	1	5	4.0	COc1ccccc1N1CCC(CNCC2COc3ccc(Cl)cc3O2)CC1	10.1021/jm9910122
		CHEMBL418854	163305	0	None	-16	8	Rat	7.6	pKi	=	7.6	Binding	The compound was tested for binding affinity against 5-hydroxytryptamine 7 receptorThe compound was tested for binding affinity against 5-hydroxytryptamine 7 receptor	ChEMBL	402	6	1	5	4.0	COc1ccccc1N1CCC(CNCC2COc3ccc(Cl)cc3O2)CC1	10.1021/jm9910122
		10355252	15032	0	None	2	3	Rat	7.6	pKi	=	7.6	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	260	0	0	2	3.5	CN1CCc2ccc3cnc4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
		CHEMBL120927	15032	0	None	2	3	Rat	7.6	pKi	=	7.6	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	260	0	0	2	3.5	CN1CCc2ccc3cnc4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
		44266253	98158	1	None	35	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	405	4	0	5	3.3	O=C1c2ccccc2CCCN1CCN1CCC(n2c(=O)oc3ccccc32)CC1	10.1016/s0960-894x(03)00077-5
		CHEMBL273821	98158	1	None	35	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	405	4	0	5	3.3	O=C1c2ccccc2CCCN1CCN1CCC(n2c(=O)oc3ccccc32)CC1	10.1016/s0960-894x(03)00077-5
		44324325	107157	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	281	3	2	4	3.0	COc1ccc(-c2cccc(NC3=NCCN3)c2C)cc1	10.1016/s0960-894x(02)00925-3
		CHEMBL316283	107157	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	281	3	2	4	3.0	COc1ccc(-c2cccc(NC3=NCCN3)c2C)cc1	10.1016/s0960-894x(02)00925-3
		10683945	98044	0	None	6	4	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	277	0	1	2	3.0	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@]3(C)O	10.1021/jm9911433
		CHEMBL27309	98044	0	None	6	4	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	277	0	1	2	3.0	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@]3(C)O	10.1021/jm9911433
		155558563	174759	0	None	-13	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	402	6	1	5	3.8	O=c1[nH]c(CCCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccsc12	10.1016/j.ejmech.2019.111690
		CHEMBL4561000	174759	0	None	-13	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	402	6	1	5	3.8	O=c1[nH]c(CCCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccsc12	10.1016/j.ejmech.2019.111690
		23111951	68413	10	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	330	6	1	3	2.4	O=S(=O)(NCCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2011.09.044
		CHEMBL1917334	68413	10	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	330	6	1	3	2.4	O=S(=O)(NCCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2011.09.044
		68281137	112080	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	498	9	1	7	3.6	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
		CHEMBL3289974	112080	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	498	9	1	7	3.6	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
		168284109	190747	0	None	-151	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	420	7	0	7	2.3	COc1ccccc1N1CCN(CCCN2CCN(c3ncccc3C#N)CC2)CC1	10.1016/j.ejmech.2022.114193
		CHEMBL5182877	190747	0	None	-151	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	420	7	0	7	2.3	COc1ccccc1N1CCN(CCCN2CCN(c3ncccc3C#N)CC2)CC1	10.1016/j.ejmech.2022.114193
		44408998	140392	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	321	6	0	3	3.6	O=S(=O)(c1ccccc1)C1(CCCN2CCCCC2)CCC1	10.1016/j.bmcl.2005.11.067
		CHEMBL380863	140392	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	321	6	0	3	3.6	O=S(=O)(c1ccccc1)C1(CCCN2CCCCC2)CCC1	10.1016/j.bmcl.2005.11.067
		44439402	169378	0	None	1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	292	2	1	2	3.4	OC1CCc2ccc(/N=C/N3CCc4ccccc4C3)cc21	10.1016/j.bmcl.2007.01.093
		CHEMBL442093	169378	0	None	1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	292	2	1	2	3.4	OC1CCc2ccc(/N=C/N3CCc4ccccc4C3)cc21	10.1016/j.bmcl.2007.01.093
		168279047	191185	0	None	-269	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	437	8	0	8	2.7	O=c1n(CCCCCCN2CCN(c3cccc4c3OCCO4)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
		CHEMBL5189101	191185	0	None	-269	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	437	8	0	8	2.7	O=c1n(CCCCCCN2CCN(c3cccc4c3OCCO4)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
		53323187	57018	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	306	3	1	2	4.0	Fc1cccc(-c2cn(Cc3ccccc3)c3c2CNCC3)c1	10.1016/j.bmcl.2010.11.078
		CHEMBL1644278	57018	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	306	3	1	2	4.0	Fc1cccc(-c2cn(Cc3ccccc3)c3c2CNCC3)c1	10.1016/j.bmcl.2010.11.078
		58405225	110699	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	323	6	1	6	2.8	CC(C)c1noc(COc2ccc(Cl)cc2OC2CNC2)n1	10.1021/ml500082j
		CHEMBL3260338	110699	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	323	6	1	6	2.8	CC(C)c1noc(COc2ccc(Cl)cc2OC2CNC2)n1	10.1021/ml500082j
		155538144	172396	0	None	12	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	295	3	1	3	4.0	CCn1cncc1-c1c[nH]c2ccc(OC(F)(F)F)cc12	10.1016/j.ejmech.2019.03.017
		CHEMBL4476520	172396	0	None	12	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	295	3	1	3	4.0	CCn1cncc1-c1c[nH]c2ccc(OC(F)(F)F)cc12	10.1016/j.ejmech.2019.03.017
		164617626	185460	0	None	-9	7	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	324	6	1	5	2.4	Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
		CHEMBL4861794	185460	0	None	-9	7	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	324	6	1	5	2.4	Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
		155565813	175808	0	None	-1380	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	350	6	3	3	4.6	Oc1ccc(-c2ccc(CNCCc3c[nH]c4cc(F)ccc34)o2)cc1	10.1016/j.ejmech.2019.111857
		CHEMBL4584504	175808	0	None	-1380	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	350	6	3	3	4.6	Oc1ccc(-c2ccc(CNCCc3c[nH]c4cc(F)ccc34)o2)cc1	10.1016/j.ejmech.2019.111857
		145975992	163516	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	393	4	1	3	3.6	O=C1Nc2ccccc2C12CCN(CCN1CCC(c3ccc(F)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
		CHEMBL4202520	163516	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	393	4	1	3	3.6	O=C1Nc2ccccc2C12CCN(CCN1CCC(c3ccc(F)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
		164608999	184384	0	None	-18	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	310	6	1	4	2.8	Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
		CHEMBL4845741	184384	0	None	-18	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	310	6	1	4	2.8	Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
		71602640	89682	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1ccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2013.02.038
		CHEMBL2376450	89682	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1ccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2013.02.038
		52952424	62595	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	360	5	1	5	3.1	OC(CCN1CCC(N2CCOCC2)CC1)c1csc2ccccc12	10.1021/jm2000773
		CHEMBL1782812	62595	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	360	5	1	5	3.1	OC(CCN1CCC(N2CCOCC2)CC1)c1csc2ccccc12	10.1021/jm2000773
		45268647	196245	0	None	64	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	414	7	3	3	3.1	Cc1cccc(S(=O)(=O)NCCCNC(=N)N2CCC(c3ccccc3)CC2)c1	10.1016/j.bmcl.2009.06.038
		CHEMBL561750	196245	0	None	64	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	414	7	3	3	3.1	Cc1cccc(S(=O)(=O)NCCCNC(=N)N2CCC(c3ccccc3)CC2)c1	10.1016/j.bmcl.2009.06.038
		71449627	81359	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	406	7	1	4	4.7	O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccs1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159307	81359	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	406	7	1	4	4.7	O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccs1	10.1016/j.ejmech.2012.07.043
		53377238	66374	0	None	-45	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	443	7	0	7	3.6	COc1ccccc1N1CCN(CCCCn2cnc3c(cnc4ccccc43)c2=O)CC1	10.1016/j.ejmech.2011.04.060
		CHEMBL1851686	66374	0	None	-45	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	443	7	0	7	3.6	COc1ccccc1N1CCN(CCCCn2cnc3c(cnc4ccccc43)c2=O)CC1	10.1016/j.ejmech.2011.04.060
		CHEMBL3216945	66374	0	None	-45	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	443	7	0	7	3.6	COc1ccccc1N1CCN(CCCCn2cnc3c(cnc4ccccc43)c2=O)CC1	10.1016/j.ejmech.2011.04.060
		134131283	142144	0	None	-11	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	390	8	0	5	4.3	Cc1nc(OCCCCCN2CCN(c3ccccc3)CC2)c2ccccc2n1	10.1016/j.bmc.2016.12.039
		CHEMBL3883517	142144	0	None	-11	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	390	8	0	5	4.3	Cc1nc(OCCCCCN2CCN(c3ccccc3)CC2)c2ccccc2n1	10.1016/j.bmc.2016.12.039
		71602640	89682	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1ccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2013.02.038
		CHEMBL2376450	89682	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1ccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2013.02.038
		155552311	174041	0	None	-19	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	446	5	0	4	3.9	O=C(CCN1CCN(c2cccc(Cl)c2)CC1)N1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2016.06.080
		CHEMBL4543646	174041	0	None	-19	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	446	5	0	4	3.9	O=C(CCN1CCN(c2cccc(Cl)c2)CC1)N1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2016.06.080
		155539605	172845	0	None	-12	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cells by radioligand binding assay	ChEMBL	313	1	0	4	2.1	CC1=NC2(CCN(C)CC2)C(=O)N(c2c(C)cccc2C)C1=O	10.1016/j.ejmech.2018.12.048
		CHEMBL4514672	172845	0	None	-12	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cells by radioligand binding assay	ChEMBL	313	1	0	4	2.1	CC1=NC2(CCN(C)CC2)C(=O)N(c2c(C)cccc2C)C1=O	10.1016/j.ejmech.2018.12.048
		168291617	192035	0	None	-17	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5-HT7BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7BR (unknown origin) assessed as inhibition constant	ChEMBL	413	8	0	6	3.5	O=c1n(CCCCCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
		CHEMBL5202054	192035	0	None	-17	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5-HT7BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7BR (unknown origin) assessed as inhibition constant	ChEMBL	413	8	0	6	3.5	O=c1n(CCCCCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
		24768525	143921	0	None	-7	3	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	406	8	1	4	4.0	O=C(CCCCCN1CCN(c2ccccn2)CC1)NC1CCCc2ccccc21	10.1021/jm070487n
		CHEMBL390213	143921	0	None	-7	3	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	406	8	1	4	4.0	O=C(CCCCCN1CCN(c2ccccn2)CC1)NC1CCCc2ccccc21	10.1021/jm070487n
		145961372	161607	0	None	-128	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hrDisplacement of [3H]-5-carboxyamidotryptamine from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr	ChEMBL	311	7	0	2	5.3	c1ccc2c(OCCCCCN3CCCCCC3)cccc2c1	10.1016/j.bmc.2018.04.023
		CHEMBL4129589	161607	0	None	-128	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hrDisplacement of [3H]-5-carboxyamidotryptamine from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr	ChEMBL	311	7	0	2	5.3	c1ccc2c(OCCCCCN3CCCCCC3)cccc2c1	10.1016/j.bmc.2018.04.023
		90654688	110109	0	None	3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	489	9	1	6	3.3	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235760	110109	0	None	3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	489	9	1	6	3.3	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
		127042540	137123	0	None	-1	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	474	10	0	4	4.9	CC(C)c1ccccc1OCCN1CCC(N(CC2CC2)S(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2015.11.041
		CHEMBL3747744	137123	0	None	-1	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	474	10	0	4	4.9	CC(C)c1ccccc1OCCN1CCC(N(CC2CC2)S(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2015.11.041
		71449645	81447	0	None	-1	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	8	1	5	4.0	CC(C)c1ccccc1OCCN1CC[C@H](NS(=O)(=O)c2ccc(Cl)s2)C1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159490	81447	0	None	-1	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	8	1	5	4.0	CC(C)c1ccccc1OCCN1CC[C@H](NS(=O)(=O)c2ccc(Cl)s2)C1	10.1016/j.ejmech.2012.07.043
		25125375	177836	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	281	3	0	2	3.8	COc1cccc(-c2cccc3c2CCC(N(C)C)C3)c1	10.1016/j.bmc.2019.115262
		CHEMBL4644005	177836	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	281	3	0	2	3.8	COc1cccc(-c2cccc3c2CCC(N(C)C)C3)c1	10.1016/j.bmc.2019.115262
		127040761	136825	0	None	13	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	438	8	1	4	3.9	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)c(F)c2)CC1	10.1039/C5MD00166H
		CHEMBL3741657	136825	0	None	13	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	438	8	1	4	3.9	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)c(F)c2)CC1	10.1039/C5MD00166H
		24873384	182601	0	None	-1	4	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	255	2	1	3	2.8	CC(C)n1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
		CHEMBL4788223	182601	0	None	-1	4	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	255	2	1	3	2.8	CC(C)n1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
		118709739	113531	0	None	18	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	334	6	0	2	3.8	O=C1Cc2ccccc2N1CCCCCN1CCc2ccccc2C1	10.1021/jm500880c
		CHEMBL3321777	113531	0	None	18	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	334	6	0	2	3.8	O=C1Cc2ccccc2N1CCCCCN1CCc2ccccc2C1	10.1021/jm500880c
		122178703	121369	0	None	1	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	383	5	0	5	4.3	COc1cc2c(cc1OC(C)C)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
		CHEMBL3581248	121369	0	None	1	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	383	5	0	5	4.3	COc1cc2c(cc1OC(C)C)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
		162646653	179502	0	None	-18	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	419	7	1	5	3.5	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc(Cl)c1	10.1016/j.ejmech.2020.112149
		CHEMBL4741142	179502	0	None	-18	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	419	7	1	5	3.5	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc(Cl)c1	10.1016/j.ejmech.2020.112149
		44324536	206842	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	269	2	2	3	3.2	Cc1c(NC2=NCCN2)cccc1-c1cccc(F)c1	10.1016/s0960-894x(02)00925-3
		CHEMBL90538	206842	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	269	2	2	3	3.2	Cc1c(NC2=NCCN2)cccc1-c1cccc(F)c1	10.1016/s0960-894x(02)00925-3
		11785077	85167	0	None	1	2	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	451	9	1	5	4.2	COc1ccccc1N1CCN(CCCCC(=O)NC2CCCc3c(OC)cccc32)CC1	10.1021/jm049702f
		CHEMBL225252	85167	0	None	1	2	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	451	9	1	5	4.2	COc1ccccc1N1CCN(CCCCC(=O)NC2CCCc3c(OC)cccc32)CC1	10.1021/jm049702f
		44437332	91586	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	763	23	0	8	9.0	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		CHEMBL240729	91586	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	763	23	0	8	9.0	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		11143090	52213	1	None	-4	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	366	9	0	4	4.3	COc1ccccc1N1CCN(CCCCCC(=O)c2ccccc2)CC1	10.1021/jm020994z
		CHEMBL158850	52213	1	None	-4	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	366	9	0	4	4.3	COc1ccccc1N1CCN(CCCCCC(=O)c2ccccc2)CC1	10.1021/jm020994z
		44437328	90982	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	678	17	0	8	6.7	COc1ccccc1N1CCN(CCc2cccc(OCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		CHEMBL239656	90982	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	678	17	0	8	6.7	COc1ccccc1N1CCN(CCc2cccc(OCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		142601343	185603	0	None	30	7	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	256	2	2	3	2.2	Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4863868	185603	0	None	30	7	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	256	2	2	3	2.2	Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		160510	101127	40	None	3	6	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	184	0	1	1	2.5	CC1=NCCc2c1[nH]c1ccccc21	10.1016/j.bmcl.2003.09.027
		CHEMBL1506260	101127	40	None	3	6	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	184	0	1	1	2.5	CC1=NCCc2c1[nH]c1ccccc21	10.1016/j.bmcl.2003.09.027
		CHEMBL295234	101127	40	None	3	6	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	184	0	1	1	2.5	CC1=NCCc2c1[nH]c1ccccc21	10.1016/j.bmcl.2003.09.027
		160510	101127	40	None	3	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assayDisplacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assay	ChEMBL	184	0	1	1	2.5	CC1=NCCc2c1[nH]c1ccccc21	10.1021/acs.jmedchem.0c01887
		CHEMBL1506260	101127	40	None	3	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assayDisplacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assay	ChEMBL	184	0	1	1	2.5	CC1=NCCc2c1[nH]c1ccccc21	10.1021/acs.jmedchem.0c01887
		CHEMBL295234	101127	40	None	3	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assayDisplacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assay	ChEMBL	184	0	1	1	2.5	CC1=NCCc2c1[nH]c1ccccc21	10.1021/acs.jmedchem.0c01887
		155511929	176277	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	483	8	0	4	5.4	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4436319	176277	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	483	8	0	4	5.4	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4595069	176277	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	483	8	0	4	5.4	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2019.06.028
		13069603	120608	0	None	-15	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	416	5	0	8	1.3	Cn1c(=O)c2c(ncn2CCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		CHEMBL3360993	120608	0	None	-15	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	416	5	0	8	1.3	Cn1c(=O)c2c(ncn2CCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		CHEMBL3546107	120608	0	None	-15	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	416	5	0	8	1.3	Cn1c(=O)c2c(ncn2CCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		168281754	190904	0	None	-34	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	434	6	0	8	2.7	COc1cc2ncnc(N3CCC(CN4CCN(c5ccccn5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
		CHEMBL5185101	190904	0	None	-34	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	434	6	0	8	2.7	COc1cc2ncnc(N3CCC(CN4CCN(c5ccccn5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
		122483218	138112	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	425	7	0	4	5.4	O=C(CCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3764418	138112	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	425	7	0	4	5.4	O=C(CCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765877	138112	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	425	7	0	4	5.4	O=C(CCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		57390695	70467	0	None	-21	8	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	427	7	0	5	5.5	O=C(CCCCN1CCCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
		CHEMBL1946257	70467	0	None	-21	8	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	427	7	0	5	5.5	O=C(CCCCN1CCCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
		24768518	92839	0	None	-46	3	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	461	11	1	3	5.9	CCCCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
		CHEMBL243743	92839	0	None	-46	3	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	461	11	1	3	5.9	CCCCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
		122483218	138112	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	425	7	0	4	5.4	O=C(CCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3764418	138112	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	425	7	0	4	5.4	O=C(CCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765877	138112	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	425	7	0	4	5.4	O=C(CCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		76328890	106418	0	None	-4	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	278	4	0	2	4.0	Cc1ccccc1-n1cc(CCN(C)C)c2ccccc21	10.1016/j.ejmech.2014.01.055
		CHEMBL3121414	106418	0	None	-4	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	278	4	0	2	4.0	Cc1ccccc1-n1cc(CCN(C)C)c2ccccc21	10.1016/j.ejmech.2014.01.055
		CHEMBL3139522	106418	0	None	-4	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	278	4	0	2	4.0	Cc1ccccc1-n1cc(CCN(C)C)c2ccccc21	10.1016/j.ejmech.2014.01.055
		44347445	16292	0	None	-1	4	Rat	6.6	pKi	=	6.6	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	277	0	0	3	3.0	CN1CCc2ccc3c(=O)oc4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
		CHEMBL122485	16292	0	None	-1	4	Rat	6.6	pKi	=	6.6	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	277	0	0	3	3.0	CN1CCc2ccc3c(=O)oc4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
		145972025	164479	0	None	1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	409	4	1	3	4.1	O=C1Nc2ccccc2C12CCN(CCN1CCC(c3ccc(Cl)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
		CHEMBL4214208	164479	0	None	1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	409	4	1	3	4.1	O=C1Nc2ccccc2C12CCN(CCN1CCC(c3ccc(Cl)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
		127026142	137756	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	384	7	1	3	4.2	CC(C)c1ccccc1OCCN1CCC(NC(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
		CHEMBL3759273	137756	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	384	7	1	3	4.2	CC(C)c1ccccc1OCCN1CCC(NC(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
		155524957	176345	0	None	-2	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	483	8	0	4	5.4	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4455845	176345	0	None	-2	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	483	8	0	4	5.4	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4595569	176345	0	None	-2	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	483	8	0	4	5.4	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmc.2019.06.028
		127049061	140767	0	None	-1	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	440	6	1	5	5.3	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
		CHEMBL3818398	140767	0	None	-1	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	440	6	1	5	5.3	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
		44582708	186838	0	None	-2	5	Human	5.5	pKi	=	5.5	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	415	10	0	5	4.2	COc1ccc(CCN2CCC(C(=O)c3cccc(OCCF)c3OC)CC2)cc1	10.1016/j.bmc.2009.03.021
		CHEMBL489408	186838	0	None	-2	5	Human	5.5	pKi	=	5.5	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	415	10	0	5	4.2	COc1ccc(CCN2CCC(C(=O)c3cccc(OCCF)c3OC)CC2)cc1	10.1016/j.bmc.2009.03.021
		155554462	174601	0	None	-109	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	316	4	1	7	1.5	CN1CCN(c2nc(N)nc(CSc3ccccc3)n2)CC1	10.1016/j.ejmech.2019.06.022
		CHEMBL4557247	174601	0	None	-109	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	316	4	1	7	1.5	CN1CCN(c2nc(N)nc(CSc3ccccc3)n2)CC1	10.1016/j.ejmech.2019.06.022
		44460759	104226	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	275	3	0	3	2.4	CN1CCCN(CCn2ccc3ccc(F)cc32)CC1	10.1016/s0960-894x(02)00438-9
		CHEMBL309908	104226	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	275	3	0	3	2.4	CN1CCCN(CCn2ccc3ccc(F)cc32)CC1	10.1016/s0960-894x(02)00438-9
		127049061	140767	0	None	-1	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	440	6	1	5	5.3	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
		CHEMBL3818398	140767	0	None	-1	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	440	6	1	5	5.3	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
		162663279	183718	0	None	-4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	411	10	2	5	3.4	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4779939	183718	0	None	-4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	411	10	2	5	3.4	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4803352	183718	0	None	-4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	411	10	2	5	3.4	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
		156013588	177201	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	353	3	2	4	2.9	COc1cc2c3c(c1OC)-c1cc(NC(N)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
		CHEMBL4635229	177201	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	353	3	2	4	2.9	COc1cc2c3c(c1OC)-c1cc(NC(N)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
		9817810	17372	1	None	-12	8	Human	7.5	pKi	=	7.5	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	300	4	1	4	2.4	NCCc1cccc2c1ccn2S(=O)(=O)c1ccccc1	10.1021/jm010943m
		CHEMBL125745	17372	1	None	-12	8	Human	7.5	pKi	=	7.5	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	300	4	1	4	2.4	NCCc1cccc2c1ccn2S(=O)(=O)c1ccccc1	10.1021/jm010943m
		137652310	157250	0	None	4	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	482	6	0	5	4.0	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3ccc(F)cc3)CC2)CC1	10.1016/j.bmc.2017.04.046
		CHEMBL4076525	157250	0	None	4	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	482	6	0	5	4.0	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3ccc(F)cc3)CC2)CC1	10.1016/j.bmc.2017.04.046
		57399092	68434	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	468	9	0	6	3.5	CCN(CCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1ccc2ncccc2c1	10.1016/j.bmc.2011.09.044
		CHEMBL1917355	68434	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	468	9	0	6	3.5	CCN(CCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1ccc2ncccc2c1	10.1016/j.bmc.2011.09.044
		145969402	164818	0	None	2	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	410	4	1	4	3.1	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccc(Cl)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
		CHEMBL4218625	164818	0	None	2	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	410	4	1	4	3.1	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccc(Cl)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
		71451457	81427	0	None	-1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	394	8	1	5	3.3	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccs2)C1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159470	81427	0	None	-1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	394	8	1	5	3.3	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccs2)C1	10.1016/j.ejmech.2012.07.043
		155543250	173299	0	None	8	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	275	1	1	2	3.3	Cn1cncc1-c1c[nH]c2ccc(Br)cc12	10.1016/j.ejmech.2019.03.017
		CHEMBL4526012	173299	0	None	8	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	275	1	1	2	3.3	Cn1cncc1-c1c[nH]c2ccc(Br)cc12	10.1016/j.ejmech.2019.03.017
		142601343	185603	0	None	30	7	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	256	2	2	3	2.2	Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4863868	185603	0	None	30	7	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	256	2	2	3	2.2	Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		56944955	159691	0	None	-7	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	465	6	2	3	5.0	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc2ccccc12	10.1021/acs.jmedchem.7b00839
		CHEMBL4104216	159691	0	None	-7	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	465	6	2	3	5.0	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc2ccccc12	10.1021/acs.jmedchem.7b00839
		118706284	120524	0	None	-31	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	285	1	3	2	1.3	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(F)c1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3310112	120524	0	None	-31	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	285	1	3	2	1.3	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(F)c1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3545440	120524	0	None	-31	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	285	1	3	2	1.3	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(F)c1-2	10.1016/j.bmc.2014.05.027
		118709753	113544	0	None	16	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	326	5	0	2	3.9	O=C1Cc2ccccc2N1CCCCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
		CHEMBL3321795	113544	0	None	16	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	326	5	0	2	3.9	O=C1Cc2ccccc2N1CCCCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
		66801335	112053	0	None	-3	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	500	8	1	7	3.7	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
		CHEMBL3289948	112053	0	None	-3	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	500	8	1	7	3.7	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
		109026956	173428	2	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	393	6	0	5	1.9	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2016.06.080
		CHEMBL4528701	173428	2	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	393	6	0	5	1.9	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2016.06.080
		11102049	103372	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	429	6	2	3	4.9	COc1ccc2[nH]c3c(c2c1)CCN(CCCCC12CCCc4cccc(c41)NC2=O)C3	10.1021/jm0104264
		CHEMBL308461	103372	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	429	6	2	3	4.9	COc1ccc2[nH]c3c(c2c1)CCN(CCCCC12CCCc4cccc(c41)NC2=O)C3	10.1021/jm0104264
		162649235	180074	0	None	-46	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	473	7	1	6	4.5	Cc1c(S(=O)(=O)N[C@@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(F)cc12	10.1016/j.ejmech.2020.112149
		CHEMBL4747978	180074	0	None	-46	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	473	7	1	6	4.5	Cc1c(S(=O)(=O)N[C@@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(F)cc12	10.1016/j.ejmech.2020.112149
		9921064	127178	25	None	-10	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	236	3	1	1	3.2	Cc1[nH]c2ccc(Cl)cc2c1CCN(C)C	10.1021/acs.jmedchem.5b00179
		CHEMBL365751	127178	25	None	-10	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	236	3	1	1	3.2	Cc1[nH]c2ccc(Cl)cc2c1CCN(C)C	10.1021/acs.jmedchem.5b00179
		145964154	164320	0	None	7	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccccc1Cl	10.1021/acs.jmedchem.8b00828
		CHEMBL4212339	164320	0	None	7	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccccc1Cl	10.1021/acs.jmedchem.8b00828
		53317861	57020	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	318	4	1	3	3.9	COc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
		CHEMBL1644280	57020	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	318	4	1	3	3.9	COc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
		155549315	173829	0	None	-144	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	448	9	0	6	4.1	COc1ccccc1N1CCN(CCCCCCn2c(=O)n3c4c(cccc42)CCC3)CC1	10.1016/j.bmcl.2019.06.029
		CHEMBL4538667	173829	0	None	-144	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	448	9	0	6	4.1	COc1ccccc1N1CCN(CCCCCCn2c(=O)n3c4c(cccc42)CCC3)CC1	10.1016/j.bmcl.2019.06.029
		155519599	176313	0	None	-5	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.2	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4447594	176313	0	None	-5	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.2	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4595274	176313	0	None	-5	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.2	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2019.06.028
		10611439	96773	0	None	-2	3	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	261	0	0	2	3.0	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)C3=O	10.1021/jm9911433
		CHEMBL26471	96773	0	None	-2	3	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	261	0	0	2	3.0	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)C3=O	10.1021/jm9911433
		57401706	70171	0	None	-50	11	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	331	6	0	4	3.5	Fc1ccc(SCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2011.12.019
		CHEMBL1940419	70171	0	None	-50	11	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	331	6	0	4	3.5	Fc1ccc(SCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2011.12.019
		60165681	75356	0	None	-102	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	413	7	0	5	5.1	O=C(CCCCN1CCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
		CHEMBL2037528	75356	0	None	-102	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	413	7	0	5	5.1	O=C(CCCCN1CCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
		127027715	137679	0	None	3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	452	7	0	4	4.0	O=S(=O)(c1ccc(F)cc1)N1CC2CC1CN2CCOc1ccccc1-c1ccccc1	10.1016/j.ejmech.2015.11.040
		CHEMBL3758619	137679	0	None	3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	452	7	0	4	4.0	O=S(=O)(c1ccc(F)cc1)N1CC2CC1CN2CCOc1ccccc1-c1ccccc1	10.1016/j.ejmech.2015.11.040
		71455001	81439	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	400	7	1	4	2.5	O=S(=O)(NC1CCN(CCOc2cccc(F)c2)C1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159482	81439	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	400	7	1	4	2.5	O=S(=O)(NC1CCN(CCOc2cccc(F)c2)C1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2012.07.043
		142601341	185372	0	None	3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
		CHEMBL4860503	185372	0	None	3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
		9904281	47749	28	None	-6	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	215	0	2	3	2.0	NC1=Nc2ccc(Cl)c(Cl)c2CN1	10.1016/j.bmcl.2007.10.080
		CHEMBL1548	47749	28	None	-6	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	215	0	2	3	2.0	NC1=Nc2ccc(Cl)c(Cl)c2CN1	10.1016/j.bmcl.2007.10.080
		13069626	120605	0	None	-295	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	440	8	0	9	1.4	COc1ccccc1N1CCN(CCCCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1	10.1016/j.bmc.2014.11.008
		CHEMBL3361000	120605	0	None	-295	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	440	8	0	9	1.4	COc1ccccc1N1CCN(CCCCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1	10.1016/j.bmc.2014.11.008
		CHEMBL3546103	120605	0	None	-295	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	440	8	0	9	1.4	COc1ccccc1N1CCN(CCCCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1	10.1016/j.bmc.2014.11.008
		90654682	110103	0	None	6	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	438	7	1	4	2.6	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235754	110103	0	None	6	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	438	7	1	4	2.6	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.03.005
		71602688	89685	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2Cl)CC1	10.1016/j.bmc.2013.02.038
		CHEMBL2376457	89685	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2Cl)CC1	10.1016/j.bmc.2013.02.038
		142601341	185372	0	None	3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
		CHEMBL4860503	185372	0	None	3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
		11560285	68415	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	394	7	1	3	4.0	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1cccc2ccccc12	10.1016/j.bmc.2011.09.044
		CHEMBL1917336	68415	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	394	7	1	3	4.0	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1cccc2ccccc12	10.1016/j.bmc.2011.09.044
		53377241	66646	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	427	6	0	6	3.9	Cc1ccccc1N1CCN(CCCCn2cnc3c(cnc4ccccc43)c2=O)CC1	10.1016/j.ejmech.2011.04.060
		CHEMBL1852852	66646	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	427	6	0	6	3.9	Cc1ccccc1N1CCN(CCCCn2cnc3c(cnc4ccccc43)c2=O)CC1	10.1016/j.ejmech.2011.04.060
		CHEMBL3216488	66646	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	427	6	0	6	3.9	Cc1ccccc1N1CCN(CCCCn2cnc3c(cnc4ccccc43)c2=O)CC1	10.1016/j.ejmech.2011.04.060
		25107717	187550	1	None	-6	3	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	420	10	1	5	3.6	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	10.1021/jm800615e
		CHEMBL494512	187550	1	None	-6	3	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	420	10	1	5	3.6	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	10.1021/jm800615e
		42618260	181550	0	None	-13	2	Human	6.5	pKi	=	6.5	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	458	7	0	7	3.6	COc1ccc(-n2c(=O)n(CCN3CCN(c4ccccc4OC)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2009.02.008
		CHEMBL476615	181550	0	None	-13	2	Human	6.5	pKi	=	6.5	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	458	7	0	7	3.6	COc1ccc(-n2c(=O)n(CCN3CCN(c4ccccc4OC)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2009.02.008
		417052	116855	43	None	-3	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	214	1	1	2	2.5	COc1ccc2[nH]c3c(c2c1)CCN=C3C	10.1016/j.bmcl.2003.09.027
		CHEMBL338115	116855	43	None	-3	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	214	1	1	2	2.5	COc1ccc2[nH]c3c(c2c1)CCN=C3C	10.1016/j.bmcl.2003.09.027
		71602688	89685	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2Cl)CC1	10.1016/j.bmc.2013.02.038
		CHEMBL2376457	89685	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2Cl)CC1	10.1016/j.bmc.2013.02.038
		155514889	169912	0	None	-4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	520	10	1	8	3.3	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ncccn4)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
		CHEMBL4440973	169912	0	None	-4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	520	10	1	8	3.3	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ncccn4)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
		11283795	142040	0	None	3	3	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	483	9	1	5	4.0	CS(=O)(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
		CHEMBL387738	142040	0	None	3	3	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	483	9	1	5	4.0	CS(=O)(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
		56850390	71484	0	None	-245	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	357	7	1	4	2.2	O=C1C2CCCN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
		CHEMBL1926733	71484	0	None	-245	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	357	7	1	4	2.2	O=C1C2CCCN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
		CHEMBL1962486	71484	0	None	-245	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	357	7	1	4	2.2	O=C1C2CCCN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
		46204421	124561	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	343	5	0	3	4.6	COc1ccc(-c2ccccc2Cl)cc1OC1CN(C2CCC2)C1	nan
		CHEMBL3640568	124561	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	343	5	0	3	4.6	COc1ccc(-c2ccccc2Cl)cc1OC1CN(C2CCC2)C1	nan
		46206021	124601	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	253	3	1	2	3.4	COc1ccccc1-c1ccccc1C1CCNC1	nan
		CHEMBL3640607	124601	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	253	3	1	2	3.4	COc1ccccc1-c1ccccc1C1CCNC1	nan
		46204421	124561	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	343	5	0	3	4.6	COc1ccc(-c2ccccc2Cl)cc1OC1CN(C2CCC2)C1	nan
		CHEMBL3640568	124561	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	343	5	0	3	4.6	COc1ccc(-c2ccccc2Cl)cc1OC1CN(C2CCC2)C1	nan
		46206021	124601	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	253	3	1	2	3.4	COc1ccccc1-c1ccccc1C1CCNC1	nan
		CHEMBL3640607	124601	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	253	3	1	2	3.4	COc1ccccc1-c1ccccc1C1CCNC1	nan
		90469115	185842	4	None	-1000	17	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	410	3	1	6	3.0	O=S(=O)(c1cccc(F)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21	10.1021/acs.jmedchem.1c00224
		CHEMBL4867565	185842	4	None	-1000	17	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	410	3	1	6	3.0	O=S(=O)(c1cccc(F)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21	10.1021/acs.jmedchem.1c00224
		10154897	65263	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	350	8	3	7	3.1	CC(Nc1nc(N)nc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.ejmech.2019.111705
		CHEMBL182797	65263	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	350	8	3	7	3.1	CC(Nc1nc(N)nc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.ejmech.2019.111705
		86288948	112626	0	None	39	4	Human	8.5	pKi	=	8.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2019.111705
		CHEMBL3233679	112626	0	None	39	4	Human	8.5	pKi	=	8.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2019.111705
		CHEMBL3302600	112626	0	None	39	4	Human	8.5	pKi	=	8.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2019.111705
		44393228	64798	1	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	317	7	2	3	4.9	C[C@H](Nc1cc(NCCc2ccccc2)ccn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		CHEMBL181950	64798	1	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	317	7	2	3	4.9	C[C@H](Nc1cc(NCCc2ccccc2)ccn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		12088080	64880	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	350	8	3	7	3.1	C[C@H](Nc1nc(N)nc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
		CHEMBL182174	64880	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	350	8	3	7	3.1	C[C@H](Nc1nc(N)nc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
		44393069	66091	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	335	8	2	6	3.5	C[C@H](Nc1ncnc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
		CHEMBL183862	66091	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	335	8	2	6	3.5	C[C@H](Nc1ncnc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
		11151899	2137	13	None	1	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1016/j.bmcl.2021.128275
		8432	2137	13	None	1	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1016/j.bmcl.2021.128275
		CHEMBL4205783	2137	13	None	1	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1016/j.bmcl.2021.128275
		9863250	17995	6	None	-1	7	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/jm030030n
		CHEMBL12624	17995	6	None	-1	7	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/jm030030n
		9885982	104184	0	None	1348	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	375	3	0	3	4.0	Brc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1021/jm030030n
		CHEMBL309750	104184	0	None	1348	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	375	3	0	3	4.0	Brc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1021/jm030030n
		9885982	104184	0	None	1348	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	375	3	0	3	4.0	Brc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1016/s0960-894x(02)00438-9
		CHEMBL309750	104184	0	None	1348	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	375	3	0	3	4.0	Brc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1016/s0960-894x(02)00438-9
		9863250	17995	6	None	1	7	Rat	8.5	pKi	=	8.5	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/jm049743b
		CHEMBL12624	17995	6	None	1	7	Rat	8.5	pKi	=	8.5	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/jm049743b
		118626121	165420	0	None	1	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cccc2cnccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4238479	165420	0	None	1	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cccc2cnccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
		145983961	165425	0	None	-3	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4238679	165425	0	None	-3	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
		86288948	112626	0	None	39	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2014.01.065
		CHEMBL3233679	112626	0	None	39	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2014.01.065
		CHEMBL3302600	112626	0	None	39	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2014.01.065
		145990353	166798	0	None	42	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	488	7	2	6	2.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc4ccccc4c3)C2=O)CC1	10.1039/C8MD00168E
		CHEMBL4284331	166798	0	None	42	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	488	7	2	6	2.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc4ccccc4c3)C2=O)CC1	10.1039/C8MD00168E
		145988738	167225	0	None	42	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	483	6	2	6	2.7	CC1(c2ccc3ccccc3c2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1039/C8MD00168E
		CHEMBL4292237	167225	0	None	42	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	483	6	2	6	2.7	CC1(c2ccc3ccccc3c2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1039/C8MD00168E
		276	3513	50	None	-100	13	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-LSD from human 5HT6 receptor expressed in BHK cell membrane measured after 60 mins by scintillation counter methodDisplacement of [3H]-LSD from human 5HT6 receptor expressed in BHK cell membrane measured after 60 mins by scintillation counter method	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/j.ejmech.2020.113059
		5312149	3513	50	None	-100	13	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-LSD from human 5HT6 receptor expressed in BHK cell membrane measured after 60 mins by scintillation counter methodDisplacement of [3H]-LSD from human 5HT6 receptor expressed in BHK cell membrane measured after 60 mins by scintillation counter method	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/j.ejmech.2020.113059
		CHEMBL431298	3513	50	None	-100	13	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-LSD from human 5HT6 receptor expressed in BHK cell membrane measured after 60 mins by scintillation counter methodDisplacement of [3H]-LSD from human 5HT6 receptor expressed in BHK cell membrane measured after 60 mins by scintillation counter method	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/j.ejmech.2020.113059
		10495891	99104	0	None	6	3	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	319	3	0	2	4.4	CCO[C@@]1(CC)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
		CHEMBL280804	99104	0	None	6	3	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	319	3	0	2	4.4	CCO[C@@]1(CC)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
		90656710	110977	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	310	6	1	3	3.5	Oc1cccc(CCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262410	110977	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	310	6	1	3	3.5	Oc1cccc(CCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
		9863250	17995	6	None	-1	7	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/acs.jmedchem.7b01898
		CHEMBL12624	17995	6	None	-1	7	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/acs.jmedchem.7b01898
		5	139	72	None	-3	54	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0341204
		5202	139	72	None	-3	54	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0341204
		CHEMBL39	139	72	None	-3	54	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0341204
		DB08839	139	72	None	-3	54	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0341204
		44364048	39139	0	None	-1	6	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	262	6	3	3	2.3	NCCCC1(CCCN)CCc2cccc(O)c2C1	10.1021/jm0341204
		CHEMBL146942	39139	0	None	-1	6	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	262	6	3	3	2.3	NCCCC1(CCCN)CCc2cccc(O)c2C1	10.1021/jm0341204
		9863250	17995	6	None	1	7	Rat	8.5	pKi	=	8.5	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1016/s0960-894x(00)00166-9
		CHEMBL12624	17995	6	None	1	7	Rat	8.5	pKi	=	8.5	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1016/s0960-894x(00)00166-9
		9863250	17995	6	None	-1	7	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor 7(a) (human cloned receptor in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor 7(a) (human cloned receptor in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/jm991151j
		CHEMBL12624	17995	6	None	-1	7	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor 7(a) (human cloned receptor in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor 7(a) (human cloned receptor in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/jm991151j
		9863250	17995	6	None	-1	7	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/jm030841r
		CHEMBL12624	17995	6	None	-1	7	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/jm030841r
		10500557	16680	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	389	6	1	3	4.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
		CHEMBL12427	16680	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	389	6	1	3	4.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
		10500557	16680	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	389	6	1	3	4.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm030841r
		CHEMBL12427	16680	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	389	6	1	3	4.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm030841r
		9863250	17995	6	None	-1	7	Human	8.5	pKi	=	8.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1016/j.ejmech.2019.111705
		CHEMBL12624	17995	6	None	-1	7	Human	8.5	pKi	=	8.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1016/j.ejmech.2019.111705
		2389	3331	118	None	-7	67	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2015.09.045
		5073	3331	118	None	-7	67	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2015.09.045
		96	3331	118	None	-7	67	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2015.09.045
		CHEMBL85	3331	118	None	-7	67	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2015.09.045
		DB00734	3331	118	None	-7	67	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2015.09.045
		10028436	3532	5	None	-1	12	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/j.ejmech.2012.07.043
		3237	3532	5	None	-1	12	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/j.ejmech.2012.07.043
		CHEMBL95104	3532	5	None	-1	12	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/j.ejmech.2012.07.043
		145977297	163634	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method	ChEMBL	350	4	1	3	3.8	OC(CN1CCN(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2017.11.007
		CHEMBL4203932	163634	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method	ChEMBL	350	4	1	3	3.8	OC(CN1CCN(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2017.11.007
		66801230	112056	0	None	1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	436	8	1	7	3.2	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cccs1	10.1021/jm401895u
		CHEMBL3289951	112056	0	None	1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	436	8	1	7	3.2	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cccs1	10.1021/jm401895u
		56943600	112115	0	None	-5	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	515	8	1	5	5.7	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
		CHEMBL3290008	112115	0	None	-5	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	515	8	1	5	5.7	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
		66801186	112125	0	None	1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	457	7	1	7	3.2	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cnc2ccccn12	10.1021/jm401895u
		CHEMBL3290018	112125	0	None	1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	457	7	1	7	3.2	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cnc2ccccn12	10.1021/jm401895u
		155545402	173389	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-HT from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]-HT from human 5HT7 receptor expressed in CHO cells	ChEMBL	391	6	1	3	3.8	O=C1NC2C=CC=C3CCCC1(CCCCN1CCN(c4ccccc4)CC1)C32	10.1016/j.ejmech.2019.111690
		CHEMBL4527987	173389	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-HT from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]-HT from human 5HT7 receptor expressed in CHO cells	ChEMBL	391	6	1	3	3.8	O=C1NC2C=CC=C3CCCC1(CCCCN1CCN(c4ccccc4)CC1)C32	10.1016/j.ejmech.2019.111690
		11536844	115122	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		CHEMBL3343672	115122	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		145987771	167089	0	None	5	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	431	6	1	2	5.9	Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccccc2)c1	10.1016/j.ejmech.2017.12.063
		CHEMBL4289783	167089	0	None	5	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	431	6	1	2	5.9	Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccccc2)c1	10.1016/j.ejmech.2017.12.063
		44276598	95683	0	None	-1	4	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	386	6	1	2	5.2	O=C1Nc2cccc3c2[C@]1(CCCCN1CC=C(c2ccccc2)CC1)CCC3	10.1021/jm0108505
		CHEMBL25815	95683	0	None	-1	4	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	386	6	1	2	5.2	O=C1Nc2cccc3c2[C@]1(CCCCN1CC=C(c2ccccc2)CC1)CCC3	10.1021/jm0108505
		8431	1484	9	None	22	5	Human	8.5	pKi	=	8.5	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.bmcl.2009.12.027
		9843179	1484	9	None	22	5	Human	8.5	pKi	=	8.5	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.bmcl.2009.12.027
		CHEMBL69257	1484	9	None	22	5	Human	8.5	pKi	=	8.5	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.bmcl.2009.12.027
		10500557	16680	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	389	6	1	3	4.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm0104264
		CHEMBL12427	16680	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	389	6	1	3	4.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm0104264
		10500557	16680	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	389	6	1	3	4.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm980519u
		CHEMBL12427	16680	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	389	6	1	3	4.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm980519u
		10825325	99424	0	None	1	5	Rat	8.5	pKi	=	8.5	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	261	0	0	1	3.9	C[C@@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
		CHEMBL282863	99424	0	None	1	5	Rat	8.5	pKi	=	8.5	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	261	0	0	1	3.9	C[C@@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
		11267988	66829	0	None	-2	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	309	6	0	2	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2010.01.035
		CHEMBL186112	66829	0	None	-2	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	309	6	0	2	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2010.01.035
		11186985	123846	0	None	-3	4	Rat	8.5	pKi	=	8.5	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	307	6	0	1	5.3	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2)C1	10.1021/jm0498102
		CHEMBL362540	123846	0	None	-3	4	Rat	8.5	pKi	=	8.5	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	307	6	0	1	5.3	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2)C1	10.1021/jm0498102
		23369416	182487	2	None	-3	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	366	6	1	5	2.6	COc1ccccc1N1CCN(CCCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
		CHEMBL478680	182487	2	None	-3	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	366	6	1	5	2.6	COc1ccccc1N1CCN(CCCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
		66801379	112071	0	None	2	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	487	8	1	8	3.8	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
		CHEMBL3289966	112071	0	None	2	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	487	8	1	8	3.8	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
		24854267	157901	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	385	6	1	3	4.0	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccc(F)cc2)CC1	10.1021/jm070279v
		CHEMBL408426	157901	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	385	6	1	3	4.0	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccc(F)cc2)CC1	10.1021/jm070279v
		155512409	169644	0	None	1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	432	6	0	6	4.3	Cn1c(CCCCN2CCN(c3ccccc3)CC2)nc2c(sc3ccccc32)c1=O	10.1016/j.ejmech.2019.111690
		CHEMBL4437217	169644	0	None	1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	432	6	0	6	4.3	Cn1c(CCCCN2CCN(c3ccccc3)CC2)nc2c(sc3ccccc32)c1=O	10.1016/j.ejmech.2019.111690
		155546781	173628	0	None	36	2	Human	8.5	pKi	=	8.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	470	7	2	4	4.1	CNC(=O)Cn1c2c(c3ccccc31)CN(CCCCC13CCCc4cccc(c41)NC3=O)CC2	10.1016/j.ejmech.2019.111705
		CHEMBL4533865	173628	0	None	36	2	Human	8.5	pKi	=	8.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	470	7	2	4	4.1	CNC(=O)Cn1c2c(c3ccccc31)CN(CCCCC13CCCc4cccc(c41)NC3=O)CC2	10.1016/j.ejmech.2019.111705
		11025847	163308	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	404	6	1	2	5.3	O=C1Nc2cccc3c2C1(CCCCN1CC=C(c2ccc(F)cc2)CC1)CCC3	10.1016/s0960-894x(02)00842-9
		CHEMBL418888	163308	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	404	6	1	2	5.3	O=C1Nc2cccc3c2C1(CCCCN1CC=C(c2ccc(F)cc2)CC1)CCC3	10.1016/s0960-894x(02)00842-9
		11025847	163308	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	404	6	1	2	5.3	O=C1Nc2cccc3c2C1(CCCCN1CC=C(c2ccc(F)cc2)CC1)CCC3	10.1021/jm0104264
		CHEMBL418888	163308	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	404	6	1	2	5.3	O=C1Nc2cccc3c2C1(CCCCN1CC=C(c2ccc(F)cc2)CC1)CCC3	10.1021/jm0104264
		9956365	195518	0	None	34	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	470	7	2	4	4.1	CNC(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
		CHEMBL553794	195518	0	None	34	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	470	7	2	4	4.1	CNC(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
		91864602	140738	0	None	2	8	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	313	5	0	2	4.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818047	140738	0	None	2	8	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	313	5	0	2	4.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.05.053
		9956365	195518	0	None	34	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	470	7	2	4	4.1	CNC(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm070279v
		CHEMBL553794	195518	0	None	34	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	470	7	2	4	4.1	CNC(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm070279v
		91864602	140738	0	None	2	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	313	5	0	2	4.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818047	140738	0	None	2	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	313	5	0	2	4.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.05.053
		11016205	204768	1	None	-2	5	Human	8.4	pKi	=	8.4	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	437	5	0	2	4.6	O=C(c1ccc(F)cc1)C1CCN(CCc2ccccc2I)CC1	10.1021/jm0200411
		CHEMBL74756	204768	1	None	-2	5	Human	8.4	pKi	=	8.4	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	437	5	0	2	4.6	O=C(c1ccc(F)cc1)C1CCN(CCc2ccccc2I)CC1	10.1021/jm0200411
		11978813	721	79	None	-6	24	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	10.1016/j.ejmech.2019.111736
		5014	721	79	None	-6	24	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	10.1016/j.ejmech.2019.111736
		7672	721	79	None	-6	24	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	10.1016/j.ejmech.2019.111736
		CHEMBL2105760	721	79	None	-6	24	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	10.1016/j.ejmech.2019.111736
		DB09128	721	79	None	-6	24	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	10.1016/j.ejmech.2019.111736
		4106	2502	22	None	-4	34	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm030030n
		5358812	2502	22	None	-4	34	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm030030n
		89	2502	22	None	-4	34	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm030030n
		CHEMBL93240	2502	22	None	-4	34	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm030030n
		24854044	97299	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(Cl)cc21	10.1021/jm070279v
		CHEMBL269083	97299	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(Cl)cc21	10.1021/jm070279v
		46196448	124542	1	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	323	4	1	3	3.7	COc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
		CHEMBL3640550	124542	1	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	323	4	1	3	3.7	COc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
		11725453	99080	0	None	1	6	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm030030n
		CHEMBL28056	99080	0	None	1	6	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm030030n
		46196448	124542	1	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	323	4	1	3	3.7	COc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
		CHEMBL3640550	124542	1	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	323	4	1	3	3.7	COc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
		11725453	99080	0	None	1	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmc.2020.115578
		CHEMBL28056	99080	0	None	1	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmc.2020.115578
		11725453	99080	0	None	-1	6	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0108505
		CHEMBL28056	99080	0	None	-1	6	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0108505
		11725453	99080	0	None	-1	6	Rat	8.4	pKi	=	8.4	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0498102
		CHEMBL28056	99080	0	None	-1	6	Rat	8.4	pKi	=	8.4	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0498102
		66800942	112045	0	None	2	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	416	6	1	6	2.7	Cc1cccc(S(=O)(=O)NCCN2CCN(c3nsc4ccccc34)CC2)c1	10.1021/jm401895u
		CHEMBL3289708	112045	0	None	2	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	416	6	1	6	2.7	Cc1cccc(S(=O)(=O)NCCN2CCN(c3nsc4ccccc34)CC2)c1	10.1021/jm401895u
		11465618	102398	23	None	-14	19	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
		CHEMBL3039528	102398	23	None	-14	19	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
		CHEMBL5191141	102398	23	None	-14	19	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
		10811746	98070	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	414	6	1	4	4.1	N#Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
		CHEMBL273246	98070	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	414	6	1	4	4.1	N#Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
		10811746	98070	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	414	6	1	4	4.1	N#Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm980519u
		CHEMBL273246	98070	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	414	6	1	4	4.1	N#Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm980519u
		25107648	187223	0	None	25	3	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	467	8	0	3	5.6	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCc2ccccc2C1	10.1021/jm800615e
		CHEMBL492480	187223	0	None	25	3	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	467	8	0	3	5.6	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCc2ccccc2C1	10.1021/jm800615e
		76284724	105004	0	None	39	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	490	11	1	5	4.9	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(F)nc3)CC2)cc1	10.1016/j.bmc.2014.01.016
		CHEMBL3113593	105004	0	None	39	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	490	11	1	5	4.9	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(F)nc3)CC2)cc1	10.1016/j.bmc.2014.01.016
		11047374	18909	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	388	6	1	2	5.3	O=C1Nc2cccc3c2C1(CCCCN1CCC(c2ccccc2)CC1)CCC3	10.1021/jm0104264
		CHEMBL12846	18909	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	388	6	1	2	5.3	O=C1Nc2cccc3c2C1(CCCCN1CCC(c2ccccc2)CC1)CCC3	10.1021/jm0104264
		10835110	114588	0	None	79	8	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	404	5	0	3	4.3	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1	10.1021/jm991151j
		CHEMBL333784	114588	0	None	79	8	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	404	5	0	3	4.3	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1	10.1021/jm991151j
		44368732	46148	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	404	5	0	3	4.3	CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1	10.1021/jm030841r
		CHEMBL153398	46148	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	404	5	0	3	4.3	CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1	10.1021/jm030841r
		11725453	99080	0	None	-1	6	Rat	8.4	pKi	=	8.4	Binding	Binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligandBinding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligand	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm030841r
		CHEMBL28056	99080	0	None	-1	6	Rat	8.4	pKi	=	8.4	Binding	Binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligandBinding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligand	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm030841r
		10811746	98070	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	414	6	1	4	4.1	N#Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1016/s0960-894x(00)00166-9
		CHEMBL273246	98070	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	414	6	1	4	4.1	N#Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1016/s0960-894x(00)00166-9
		10811746	98070	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	414	6	1	4	4.1	N#Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm030841r
		CHEMBL273246	98070	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	414	6	1	4	4.1	N#Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm030841r
		162656718	180958	0	None	2	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	403	7	1	5	3.0	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)cc1	10.1016/j.ejmech.2020.112149
		CHEMBL4758402	180958	0	None	2	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	403	7	1	5	3.0	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)cc1	10.1016/j.ejmech.2020.112149
		4106	2502	22	None	-4	34	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2019.111705
		5358812	2502	22	None	-4	34	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2019.111705
		89	2502	22	None	-4	34	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2019.111705
		CHEMBL93240	2502	22	None	-4	34	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2019.111705
		145	140	49	None	-2	30	Human	7.5	pKi	=	7.5	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm030030n
		1832	140	49	None	-2	30	Human	7.5	pKi	=	7.5	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm030030n
		CHEMBL7257	140	49	None	-2	30	Human	7.5	pKi	=	7.5	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm030030n
		DB14010	140	49	None	-2	30	Human	7.5	pKi	=	7.5	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm030030n
		398712	77869	5	None	-30	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay	ChEMBL	417	9	1	5	2.9	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1021/jm0508641
		CHEMBL209324	77869	5	None	-30	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay	ChEMBL	417	9	1	5	2.9	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1021/jm0508641
		122483281	138108	0	None	-6	8	Human	7.5	pKi	=	7.5	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3763779	138108	0	None	-6	8	Human	7.5	pKi	=	7.5	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3765873	138108	0	None	-6	8	Human	7.5	pKi	=	7.5	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL5083607	214873	0	None	-2	9	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl	10.1021/acs.jmedchem.1c00110
		71574212	86284	0	None	-3	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccccc2c1	10.1016/j.ejmech.2012.11.042
		CHEMBL2312935	86284	0	None	-3	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccccc2c1	10.1016/j.ejmech.2012.11.042
		118731349	118186	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	8	1	4	3.5	CC(C)c1ccccc1N1CCN(CCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.12.041
		CHEMBL3409033	118186	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	8	1	4	3.5	CC(C)c1ccccc1N1CCN(CCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.12.041
		118731359	118195	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	532	10	0	5	4.3	O=C([C@@H]1CCCN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCOCC1	10.1016/j.ejmech.2014.12.041
		CHEMBL3409042	118195	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	532	10	0	5	4.3	O=C([C@@H]1CCCN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCOCC1	10.1016/j.ejmech.2014.12.041
		156014079	177256	0	None	1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	508	10	1	6	5.1	O=S(=O)(NCCCCCCN1CCN(c2nsc3ccccc23)CC1)c1cccc2ccccc12	10.1016/j.bmc.2020.115459
		CHEMBL4636031	177256	0	None	1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	508	10	1	6	5.1	O=S(=O)(NCCCCCCN1CCN(c2nsc3ccccc23)CC1)c1cccc2ccccc12	10.1016/j.bmc.2020.115459
		138691338	163667	0	None	21	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	241	3	1	3	3.1	CCn1cncc1-c1c[nH]c2ccc(OC)cc12	10.1016/j.ejmech.2019.03.017
		CHEMBL4204595	163667	0	None	21	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	241	3	1	3	3.1	CCn1cncc1-c1c[nH]c2ccc(OC)cc12	10.1016/j.ejmech.2019.03.017
		11425677	182335	0	None	-1	4	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	269	1	1	3	3.0	CC(C)(C)n1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
		CHEMBL4784424	182335	0	None	-1	4	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	269	1	1	3	3.0	CC(C)(C)n1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
		138691338	163667	0	None	21	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes by Cheng-Prusoff equation analysisDisplacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes by Cheng-Prusoff equation analysis	ChEMBL	241	3	1	3	3.1	CCn1cncc1-c1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.7b01898
		CHEMBL4204595	163667	0	None	21	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes by Cheng-Prusoff equation analysisDisplacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes by Cheng-Prusoff equation analysis	ChEMBL	241	3	1	3	3.1	CCn1cncc1-c1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.7b01898
		90656694	110995	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	339	7	1	4	3.4	CN(CCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262428	110995	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	339	7	1	4	3.4	CN(CCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		10171	56	18	None	-11	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1021/jm030030n
		272	56	18	None	-11	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1021/jm030030n
		CHEMBL274384	56	18	None	-11	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1021/jm030030n
		122483281	138108	0	None	-6	8	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3763779	138108	0	None	-6	8	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3765873	138108	0	None	-6	8	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		67268994	163968	2	None	3	7	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		CHEMBL4207884	163968	2	None	3	7	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		118736368	118940	0	None	-7	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	527	7	1	10	2.7	Cn1c(=O)c2c(nc3n(CCCCN4CCN(c5ccccc5O)CC4)c(-c4ccccc4)cn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
		CHEMBL3423332	118940	0	None	-7	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	527	7	1	10	2.7	Cn1c(=O)c2c(nc3n(CCCCN4CCN(c5ccccc5O)CC4)c(-c4ccccc4)cn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
		11786227	172605	0	None	1	2	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	465	10	1	5	4.6	COc1ccc2c(c1)CCCC2NC(=O)CCCCCN1CCN(c2ccccc2OC)CC1	10.1021/jm049702f
		CHEMBL449089	172605	0	None	1	2	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	465	10	1	5	4.6	COc1ccc2c(c1)CCCC2NC(=O)CCCCCN1CCN(c2ccccc2OC)CC1	10.1021/jm049702f
		118728510	117705	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	1	5	4.1	Cc1sc2nc(CCCCCN3CCN(c4ccccc4)CC3)[nH]c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
		CHEMBL3401473	117705	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	1	5	4.1	Cc1sc2nc(CCCCCN3CCN(c4ccccc4)CC3)[nH]c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
		CHEMBL5083607	214873	0	None	-2	9	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl	10.1021/acs.jmedchem.1c00110
		122483281	138108	0	None	-6	8	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3763779	138108	0	None	-6	8	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3765873	138108	0	None	-6	8	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		12	1553	17	None	-13	7	Human	6.5	pKi	=	6.5	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10.1021/jm990550b
		6918513	1553	17	None	-13	7	Human	6.5	pKi	=	6.5	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10.1021/jm990550b
		CHEMBL267615	1553	17	None	-13	7	Human	6.5	pKi	=	6.5	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10.1021/jm990550b
		162671716	183762	0	None	-9	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	383	8	2	5	3.3	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4792591	183762	0	None	-9	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	383	8	2	5	3.3	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4803839	183762	0	None	-9	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	383	8	2	5	3.3	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
		44439405	91812	0	None	2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	440	4	0	5	5.3	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C1SCCSC1CC3)CC2	10.1016/j.bmcl.2007.01.093
		CHEMBL241282	91812	0	None	2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	440	4	0	5	5.3	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C1SCCSC1CC3)CC2	10.1016/j.bmcl.2007.01.093
		417052	116855	43	None	-3	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assayDisplacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assay	ChEMBL	214	1	1	2	2.5	COc1ccc2[nH]c3c(c2c1)CCN=C3C	10.1021/acs.jmedchem.0c01887
		CHEMBL338115	116855	43	None	-3	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assayDisplacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assay	ChEMBL	214	1	1	2	2.5	COc1ccc2[nH]c3c(c2c1)CCN=C3C	10.1021/acs.jmedchem.0c01887
		72711487	102594	0	None	-11	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	411	10	1	5	3.0	COc1ccc(OCCNCCCCN2C(=O)C3CCCN3C2=O)c2ccccc12	10.1021/jm400766k
		CHEMBL2431040	102594	0	None	-11	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	411	10	1	5	3.0	COc1ccc(OCCNCCCCN2C(=O)C3CCCN3C2=O)c2ccccc12	10.1021/jm400766k
		CHEMBL3040890	102594	0	None	-11	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	411	10	1	5	3.0	COc1ccc(OCCNCCCCN2C(=O)C3CCCN3C2=O)c2ccccc12	10.1021/jm400766k
		57399088	68416	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	373	8	1	4	2.1	NCCCN(CCN1CCc2ccccc2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2011.09.044
		CHEMBL1917337	68416	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	373	8	1	4	2.1	NCCCN(CCN1CCc2ccccc2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2011.09.044
		90654676	110097	0	None	-25	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	464	9	1	5	2.8	COc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235748	110097	0	None	-25	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	464	9	1	5	2.8	COc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
		138691366	174958	0	None	7	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	229	2	1	2	3.2	CCn1cncc1-c1c[nH]c2ccc(F)cc12	10.1016/j.ejmech.2019.03.017
		CHEMBL4565881	174958	0	None	7	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	229	2	1	2	3.2	CCn1cncc1-c1c[nH]c2ccc(F)cc12	10.1016/j.ejmech.2019.03.017
		145946733	167580	0	None	-20	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	368	7	0	4	4.2	COc1ccc(N2CCN(CCCOc3c(C)cc(C)cc3C)CC2)cc1	10.1016/j.bmcl.2018.04.059
		CHEMBL4205526	167580	0	None	-20	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	368	7	0	4	4.2	COc1ccc(N2CCN(CCCOc3c(C)cc(C)cc3C)CC2)cc1	10.1016/j.bmcl.2018.04.059
		CHEMBL4300710	167580	0	None	-20	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	368	7	0	4	4.2	COc1ccc(N2CCN(CCCOc3c(C)cc(C)cc3C)CC2)cc1	10.1016/j.bmcl.2018.04.059
		173	3262	95	None	-34	23	Human	5.5	pKi	=	5.5	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	10.1021/jm030030n
		5011	3262	95	None	-34	23	Human	5.5	pKi	=	5.5	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	10.1021/jm030030n
		CHEMBL18772	3262	95	None	-34	23	Human	5.5	pKi	=	5.5	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	10.1021/jm030030n
		1355	2011	88	None	-14	16	Human	6.5	pKi	=	6.5	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm030030n
		142	2011	88	None	-14	16	Human	6.5	pKi	=	6.5	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm030030n
		CHEMBL478	2011	88	None	-14	16	Human	6.5	pKi	=	6.5	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm030030n
		DB12110	2011	88	None	-14	16	Human	6.5	pKi	=	6.5	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm030030n
		134144798	150247	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	325	5	0	3	4.6	COc1ccccc1-c1cc(CN2CCC(C)CC2)ccc1OC	10.1016/j.ejmech.2016.07.029
		CHEMBL3952371	150247	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	325	5	0	3	4.6	COc1ccccc1-c1cc(CN2CCC(C)CC2)ccc1OC	10.1016/j.ejmech.2016.07.029
		118728521	117716	0	None	-10	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	376	7	0	5	3.4	O=c1c2ccccc2ncn1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2015.02.042
		CHEMBL3401484	117716	0	None	-10	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	376	7	0	5	3.4	O=c1c2ccccc2ncn1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2015.02.042
		156019563	177987	0	None	-3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	364	5	0	4	4.1	C=CCOc1c(OC)cc2c3c1-c1cc(N(C)C)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
		CHEMBL4646172	177987	0	None	-3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	364	5	0	4	4.1	C=CCOc1c(OC)cc2c3c1-c1cc(N(C)C)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
		71602691	89688	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	372	5	0	3	5.0	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2C)CC1	10.1016/j.bmc.2013.02.038
		CHEMBL2376460	89688	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	372	5	0	3	5.0	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2C)CC1	10.1016/j.bmc.2013.02.038
		122483260	138100	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.6	O=C(CCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3763275	138100	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.6	O=C(CCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765848	138100	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.6	O=C(CCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		11121216	30139	0	None	-15	14	Human	7.5	pKi	=	7.5	Binding	Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor	ChEMBL	335	1	1	2	3.0	C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		CHEMBL138989	30139	0	None	-15	14	Human	7.5	pKi	=	7.5	Binding	Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor	ChEMBL	335	1	1	2	3.0	C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		88912137	110698	0	None	19	4	Rat	7.5	pKi	=	7.5	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	405	5	1	3	5.2	C[C@@H](Oc1ccc(C(F)(F)F)cc1OC1CNC1)c1cccc(C(F)(F)F)c1	10.1021/ml500082j
		CHEMBL3260337	110698	0	None	19	4	Rat	7.5	pKi	=	7.5	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	405	5	1	3	5.2	C[C@@H](Oc1ccc(C(F)(F)F)cc1OC1CNC1)c1cccc(C(F)(F)F)c1	10.1021/ml500082j
		44460471	205585	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	335	3	0	3	3.0	CN1CCCN(CCn2ccc3ccc(Br)cc32)CC1	10.1016/s0960-894x(02)00438-9
		CHEMBL81424	205585	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	335	3	0	3	3.0	CN1CCCN(CCn2ccc3ccc(Br)cc32)CC1	10.1016/s0960-894x(02)00438-9
		145986138	165469	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	492	6	0	6	4.4	O=S(=O)(c1cncc2ccccc12)N1CC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4239705	165469	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	492	6	0	6	4.4	O=S(=O)(c1cncc2ccccc12)N1CC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
		71574302	86264	0	None	-2	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1	10.1016/j.ejmech.2012.11.042
		CHEMBL2312637	86264	0	None	-2	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1	10.1016/j.ejmech.2012.11.042
		71574208	86269	0	None	-1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	478	7	1	5	4.0	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2ncccc2c1	10.1016/j.ejmech.2012.11.042
		CHEMBL2312642	86269	0	None	-1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	478	7	1	5	4.0	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2ncccc2c1	10.1016/j.ejmech.2012.11.042
		156019543	177936	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	508	10	1	6	5.1	O=S(=O)(NCCCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2020.115459
		CHEMBL4645525	177936	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	508	10	1	6	5.1	O=S(=O)(NCCCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2020.115459
		90654854	112683	0	None	2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	584	9	0	4	6.8	CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.ejmech.2014.01.065
		CHEMBL3233676	112683	0	None	2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	584	9	0	4	6.8	CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.ejmech.2014.01.065
		CHEMBL3304183	112683	0	None	2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	584	9	0	4	6.8	CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.ejmech.2014.01.065
		156009483	177066	0	None	7	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	412	5	1	5	2.8	C#CCOc1c(OC)cc2c3c1-c1cc(NS(C)(=O)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
		CHEMBL4632872	177066	0	None	7	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	412	5	1	5	2.8	C#CCOc1c(OC)cc2c3c1-c1cc(NS(C)(=O)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
		42618272	91199	0	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	435	6	0	4	3.6	O=C1C2CC=CCC2C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2007.07.029
		CHEMBL239898	91199	0	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	435	6	0	4	3.6	O=C1C2CC=CCC2C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2007.07.029
		25107517	187256	0	None	-1	3	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	421	8	0	4	4.0	COc1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	10.1021/jm800615e
		CHEMBL492690	187256	0	None	-1	3	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	421	8	0	4	4.0	COc1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	10.1021/jm800615e
		72551082	114081	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	487	11	1	5	5.0	COc1ccccc1-c1ccccc1CNC(=O)CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2014.07.026
		CHEMBL3326985	114081	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	487	11	1	5	5.0	COc1ccccc1-c1ccccc1CNC(=O)CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2014.07.026
		11168662	84632	0	None	-1	2	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	465	10	1	5	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3cccc(OC)c32)CC1	10.1021/jm049702f
		CHEMBL222262	84632	0	None	-1	2	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	465	10	1	5	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3cccc(OC)c32)CC1	10.1021/jm049702f
		281	3510	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/j.ejmech.2019.111705
		5312148	3510	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/j.ejmech.2019.111705
		CHEMBL12264	3510	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/j.ejmech.2019.111705
		281	3510	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/acs.jmedchem.7b01898
		5312148	3510	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/acs.jmedchem.7b01898
		CHEMBL12264	3510	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/acs.jmedchem.7b01898
		281	3510	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/j.bmc.2013.02.038
		5312148	3510	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/j.bmc.2013.02.038
		CHEMBL12264	3510	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/j.bmc.2013.02.038
		281	3510	28	None	-1	5	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm0108505
		5312148	3510	28	None	-1	5	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm0108505
		CHEMBL12264	3510	28	None	-1	5	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm0108505
		3233	3512	44	None	-2	12	Rat	7.5	pKi	=	7.5	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030841r
		3247	3512	44	None	-2	12	Rat	7.5	pKi	=	7.5	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030841r
		6604889	3512	44	None	-2	12	Rat	7.5	pKi	=	7.5	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030841r
		CHEMBL282199	3512	44	None	-2	12	Rat	7.5	pKi	=	7.5	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030841r
		DB13988	3512	44	None	-2	12	Rat	7.5	pKi	=	7.5	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030841r
		9820952	18738	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	374	6	0	3	4.0	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm970519e
		CHEMBL12777	18738	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	374	6	0	3	4.0	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm970519e
		10715573	98491	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	392	6	0	3	4.1	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1	10.1021/jm970519e
		CHEMBL275996	98491	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	392	6	0	3	4.1	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1	10.1021/jm970519e
		281	3510	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/s0960-894x(00)00166-9
		5312148	3510	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/s0960-894x(00)00166-9
		CHEMBL12264	3510	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/s0960-894x(00)00166-9
		9820952	18738	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)CC1	10.1016/s0960-894x(00)00166-9
		CHEMBL12777	18738	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)CC1	10.1016/s0960-894x(00)00166-9
		10715573	98491	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	392	6	0	3	4.1	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(00)00166-9
		CHEMBL275996	98491	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	392	6	0	3	4.1	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(00)00166-9
		281	3510	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm030841r
		5312148	3510	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm030841r
		CHEMBL12264	3510	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm030841r
		44368358	119672	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	373	6	0	3	4.8	CC1CCN(CC[C@@H](C)C(C)S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm030841r
		CHEMBL347115	119672	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	373	6	0	3	4.8	CC1CCN(CC[C@@H](C)C(C)S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm030841r
		44368306	164889	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	391	6	0	3	4.9	CC1CCN(CC[C@@H](C)C(C)S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1	10.1021/jm030841r
		CHEMBL422146	164889	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	391	6	0	3	4.9	CC1CCN(CC[C@@H](C)C(C)S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1	10.1021/jm030841r
		142601337	185970	0	None	53	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	260	2	2	3	2.0	Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4869695	185970	0	None	53	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	260	2	2	3	2.0	Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		162674561	183271	0	None	-2	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	403	7	1	5	3.0	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)cc1	10.1016/j.ejmech.2020.112149
		CHEMBL4796647	183271	0	None	-2	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	403	7	1	5	3.0	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)cc1	10.1016/j.ejmech.2020.112149
		10171	56	18	None	-11	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1016/j.ejmech.2019.111705
		272	56	18	None	-11	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1016/j.ejmech.2019.111705
		CHEMBL274384	56	18	None	-11	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1016/j.ejmech.2019.111705
		67268994	163968	2	None	3	7	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		CHEMBL4207884	163968	2	None	3	7	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		2726	919	68	None	-13	72	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
		621	919	68	None	-13	72	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
		83	919	68	None	-13	72	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
		CHEMBL71	919	68	None	-13	72	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
		DB00477	919	68	None	-13	72	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
		44324627	206765	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	257	2	2	4	3.1	Cc1c(NC2=NCCN2)cccc1-c1ccsc1	10.1016/s0960-894x(02)00925-3
		CHEMBL90118	206765	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	257	2	2	4	3.1	Cc1c(NC2=NCCN2)cccc1-c1ccsc1	10.1016/s0960-894x(02)00925-3
		281	3510	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT. The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT.	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm970519e
		5312148	3510	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT. The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT.	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm970519e
		CHEMBL12264	3510	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT. The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT.	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm970519e
		281	3510	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT.The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT.	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm970519e
		5312148	3510	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT.The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT.	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm970519e
		CHEMBL12264	3510	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT.The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT.	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm970519e
		57403839	71546	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
		CHEMBL1949967	71546	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
		CHEMBL1963008	71546	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
		90656708	110994	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	415	8	1	4	5.5	CN(CCCN1CCC(N(c2ccccc2)c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262427	110994	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	415	8	1	4	5.5	CN(CCCN1CCC(N(c2ccccc2)c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		46205699	124594	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	251	2	0	1	4.1	Cc1cccc(-c2ccccc2C2CCN(C)C2)c1	nan
		CHEMBL3640600	124594	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	251	2	0	1	4.1	Cc1cccc(-c2ccccc2C2CCN(C)C2)c1	nan
		46205699	124594	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	251	2	0	1	4.1	Cc1cccc(-c2ccccc2C2CCN(C)C2)c1	nan
		CHEMBL3640600	124594	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	251	2	0	1	4.1	Cc1cccc(-c2ccccc2C2CCN(C)C2)c1	nan
		71449550	81168	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	410	9	1	4	4.5	CCOc1ccccc1C(=O)NC1CCN(CCOc2ccccc2C(C)C)CC1	10.1016/j.ejmech.2012.07.043
		CHEMBL2158034	81168	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	410	9	1	4	4.5	CCOc1ccccc1C(=O)NC1CCN(CCOc2ccccc2C(C)C)CC1	10.1016/j.ejmech.2012.07.043
		71602691	89688	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	372	5	0	3	5.0	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2C)CC1	10.1016/j.bmc.2013.02.038
		CHEMBL2376460	89688	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	372	5	0	3	5.0	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2C)CC1	10.1016/j.bmc.2013.02.038
		156014279	177230	0	None	-20	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	348	5	1	2	5.0	CCCC(=O)Nc1ccc2c(c1)-c1cccc3c1C(C2)N(CCC)CC3	10.1016/j.bmc.2020.115578
		CHEMBL4635676	177230	0	None	-20	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	348	5	1	2	5.0	CCCC(=O)Nc1ccc2c(c1)-c1cccc3c1C(C2)N(CCC)CC3	10.1016/j.bmc.2020.115578
		122483260	138100	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.6	O=C(CCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3763275	138100	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.6	O=C(CCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765848	138100	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.6	O=C(CCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		145973487	164620	0	None	8	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	516	7	1	4	4.0	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1ccc(Br)cc1	10.1021/acs.jmedchem.8b00828
		CHEMBL4216022	164620	0	None	8	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	516	7	1	4	4.0	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1ccc(Br)cc1	10.1021/acs.jmedchem.8b00828
		127052486	140823	0	None	-3	8	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	424	6	1	5	4.8	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3o2)CC1	10.1016/j.bmc.2016.06.011
		CHEMBL3819153	140823	0	None	-3	8	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	424	6	1	5	4.8	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3o2)CC1	10.1016/j.bmc.2016.06.011
		90654698	110084	0	None	-22	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	390	8	1	4	2.0	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2ccccc2F)CC1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235735	110084	0	None	-22	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	390	8	1	4	2.0	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2ccccc2F)CC1	10.1016/j.ejmech.2014.03.005
		145947944	167731	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	336	9	1	5	1.6	Cc1cc(C)c(C)c(OCCOCCN2CCN(CCO)CC2)c1	10.1016/j.bmcl.2018.04.059
		CHEMBL4208428	167731	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	336	9	1	5	1.6	Cc1cc(C)c(C)c(OCCOCCN2CCN(CCO)CC2)c1	10.1016/j.bmcl.2018.04.059
		CHEMBL4302764	167731	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	336	9	1	5	1.6	Cc1cc(C)c(C)c(OCCOCCN2CCN(CCO)CC2)c1	10.1016/j.bmcl.2018.04.059
		155511262	169544	0	None	-109	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	362	7	3	4	4.5	COc1ccc2[nH]cc(CCNCc3ccc(-c4cccc(O)c4)o3)c2c1	10.1016/j.ejmech.2019.111857
		CHEMBL4435528	169544	0	None	-109	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	362	7	3	4	4.5	COc1ccc2[nH]cc(CCNCc3ccc(-c4cccc(O)c4)o3)c2c1	10.1016/j.ejmech.2019.111857
		11151899	2137	13	None	-5	4	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from recombinant rat 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5-CT from recombinant rat 5-HT7 receptor expressed in HEK293 cells	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1016/j.ejmech.2019.111705
		8432	2137	13	None	-5	4	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from recombinant rat 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5-CT from recombinant rat 5-HT7 receptor expressed in HEK293 cells	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1016/j.ejmech.2019.111705
		CHEMBL4205783	2137	13	None	-5	4	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from recombinant rat 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5-CT from recombinant rat 5-HT7 receptor expressed in HEK293 cells	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1016/j.ejmech.2019.111705
		135367959	164610	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	214	1	1	3	2.0	c1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		CHEMBL4215925	164610	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	214	1	1	3	2.0	c1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		1353	1911	93	None	-263	83	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm070516u
		3559	1911	93	None	-263	83	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm070516u
		86	1911	93	None	-263	83	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm070516u
		CHEMBL54	1911	93	None	-263	83	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm070516u
		DB00502	1911	93	None	-263	83	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm070516u
		127052486	140823	0	None	-3	8	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	424	6	1	5	4.8	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3o2)CC1	10.1016/j.bmc.2016.06.011
		CHEMBL3819153	140823	0	None	-3	8	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	424	6	1	5	4.8	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3o2)CC1	10.1016/j.bmc.2016.06.011
		145947088	167624	0	None	-6	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	382	9	0	4	3.8	Cc1cc(C)c(OCCOCCN2CCN(Cc3ccccc3)CC2)c(C)c1	10.1016/j.bmcl.2018.04.059
		CHEMBL4208181	167624	0	None	-6	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	382	9	0	4	3.8	Cc1cc(C)c(OCCOCCN2CCN(Cc3ccccc3)CC2)c(C)c1	10.1016/j.bmcl.2018.04.059
		CHEMBL4301443	167624	0	None	-6	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	382	9	0	4	3.8	Cc1cc(C)c(OCCOCCN2CCN(Cc3ccccc3)CC2)c(C)c1	10.1016/j.bmcl.2018.04.059
		6918648	101559	1	None	-5128	14	Human	5.5	pKi	=	5.5	Binding	Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT	ChEMBL	465	5	1	6	4.4	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1	10.1021/jm980532e
		CHEMBL29846	101559	1	None	-5128	14	Human	5.5	pKi	=	5.5	Binding	Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT	ChEMBL	465	5	1	6	4.4	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1	10.1021/jm980532e
		6918648	101559	1	None	-5128	14	Human	5.5	pKi	=	5.5	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand	ChEMBL	465	5	1	6	4.4	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1	10.1016/s0960-894x(02)00172-5
		CHEMBL29846	101559	1	None	-5128	14	Human	5.5	pKi	=	5.5	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand	ChEMBL	465	5	1	6	4.4	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1	10.1016/s0960-894x(02)00172-5
		76314436	106267	0	None	-4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	292	4	0	2	4.4	Cc1cccc(-n2cc(CCN(C)C)c3ccccc32)c1C	10.1016/j.ejmech.2014.01.055
		CHEMBL3121415	106267	0	None	-4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	292	4	0	2	4.4	Cc1cccc(-n2cc(CCN(C)C)c3ccccc32)c1C	10.1016/j.ejmech.2014.01.055
		CHEMBL3139010	106267	0	None	-4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	292	4	0	2	4.4	Cc1cccc(-n2cc(CCN(C)C)c3ccccc32)c1C	10.1016/j.ejmech.2014.01.055
		19958494	99453	1	None	-9	4	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	360	3	1	3	3.9	FC(F)(F)c1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1	10.1016/s0960-894x(01)00241-4
		CHEMBL283036	99453	1	None	-9	4	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	360	3	1	3	3.9	FC(F)(F)c1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1	10.1016/s0960-894x(01)00241-4
		122187	3702	17	None	-104	5	Rat	5.5	pKi	=	5.5	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	265	5	1	2	3.5	CCCN([C@H]1CCc2c(C1)c(O)ccc2F)CCC	10.1021/jm9911433
		61	3702	17	None	-104	5	Rat	5.5	pKi	=	5.5	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	265	5	1	2	3.5	CCCN([C@H]1CCc2c(C1)c(O)ccc2F)CCC	10.1021/jm9911433
		CHEMBL22778	3702	17	None	-104	5	Rat	5.5	pKi	=	5.5	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	265	5	1	2	3.5	CCCN([C@H]1CCc2c(C1)c(O)ccc2F)CCC	10.1021/jm9911433
		18133517	164422	0	None	16	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2ccc(Br)cc2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
		CHEMBL4213576	164422	0	None	16	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2ccc(Br)cc2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
		127027391	137832	0	None	8	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	468	7	0	4	4.5	O=S(=O)(c1cccc(Cl)c1)N1CC2CC1CN2CCOc1ccccc1-c1ccccc1	10.1016/j.ejmech.2015.11.040
		CHEMBL3759885	137832	0	None	8	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	468	7	0	4	4.5	O=S(=O)(c1cccc(Cl)c1)N1CC2CC1CN2CCOc1ccccc1-c1ccccc1	10.1016/j.ejmech.2015.11.040
		162672202	183764	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	383	8	2	5	2.6	COc1ccccc1N1CCN(CCCC(=O)NCc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4790910	183764	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	383	8	2	5	2.6	COc1ccccc1N1CCN(CCCC(=O)NCc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4803865	183764	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	383	8	2	5	2.6	COc1ccccc1N1CCN(CCCC(=O)NCc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
		135367959	164610	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	214	1	1	3	2.0	c1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		CHEMBL4215925	164610	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	214	1	1	3	2.0	c1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		281	3510	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm030030n
		5312148	3510	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm030030n
		CHEMBL12264	3510	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm030030n
		44268087	20194	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	374	6	0	3	4.0	CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm030030n
		CHEMBL13049	20194	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	374	6	0	3	4.0	CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm030030n
		281	3510	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/s0960-894x(02)00438-9
		5312148	3510	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/s0960-894x(02)00438-9
		CHEMBL12264	3510	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/s0960-894x(02)00438-9
		145983794	165654	0	None	-2	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	0	6	5.2	O=S(=O)(c1cncc2ccccc12)N1CCCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4244280	165654	0	None	-2	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	0	6	5.2	O=S(=O)(c1cncc2ccccc12)N1CCCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
		134137332	143008	0	None	12	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	530	10	1	5	4.8	O=C(CCOCCN1CCN(c2ncccc2-c2ccc(F)cc2)CC1)NCc1ccc(C(F)(F)F)cc1	10.1016/j.ejmech.2016.05.005
		CHEMBL3894679	143008	0	None	12	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	530	10	1	5	4.8	O=C(CCOCCN1CCN(c2ncccc2-c2ccc(F)cc2)CC1)NCc1ccc(C(F)(F)F)cc1	10.1016/j.ejmech.2016.05.005
		145976890	163817	0	None	21	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	484	8	1	4	5.2	CC(COc1ccccc1-c1ccccc1)N1CCC(NS(=O)(=O)c2cccc(Cl)c2)CC1	10.1016/j.bmc.2017.03.057
		CHEMBL4206203	163817	0	None	21	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	484	8	1	4	5.2	CC(COc1ccccc1-c1ccccc1)N1CCC(NS(=O)(=O)c2cccc(Cl)c2)CC1	10.1016/j.bmc.2017.03.057
		145974189	164626	0	None	8	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	434	9	1	4	4.2	CC(C)c1ccccc1OCCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2017.03.057
		CHEMBL4216126	164626	0	None	8	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	434	9	1	4	4.2	CC(C)c1ccccc1OCCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2017.03.057
		142601337	185970	0	None	53	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	260	2	2	3	2.0	Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4869695	185970	0	None	53	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	260	2	2	3	2.0	Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		137654666	158616	0	None	-44	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	463	7	2	3	4.9	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
		CHEMBL4092243	158616	0	None	-44	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	463	7	2	3	4.9	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
		10667433	148798	0	None	6	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	379	7	0	4	3.2	COc1ccccc1N1CCN(CCCCN2C(=O)Cc3ccccc32)CC1	10.1021/jm8014553
		CHEMBL394080	148798	0	None	6	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	379	7	0	4	3.2	COc1ccccc1N1CCN(CCCCN2C(=O)Cc3ccccc32)CC1	10.1021/jm8014553
		72547878	114084	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	517	12	1	6	5.0	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2c(OC)cccc2OC)CC1	10.1016/j.bmc.2014.07.026
		CHEMBL3326988	114084	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	517	12	1	6	5.0	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2c(OC)cccc2OC)CC1	10.1016/j.bmc.2014.07.026
		155568373	176094	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	412	5	0	4	3.2	O=C(CCN1CCN(c2cccc(Cl)c2)CC1)N1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2016.06.080
		CHEMBL4591320	176094	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	412	5	0	4	3.2	O=C(CCN1CCN(c2cccc(Cl)c2)CC1)N1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2016.06.080
		25107515	187360	0	None	-16	3	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	8	0	4	4.7	CSc1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	10.1021/jm800615e
		CHEMBL493305	187360	0	None	-16	3	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	8	0	4	4.7	CSc1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	10.1021/jm800615e
		155568246	176100	0	None	-138	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	528	9	2	5	5.2	COc1ccc2[nH]cc(C3CCN(CCCCN4C(=O)CC(c5c[nH]c6ccc(OC)cc56)C4=O)CC3)c2c1	10.1016/j.ejmech.2019.111736
		CHEMBL4591440	176100	0	None	-138	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	528	9	2	5	5.2	COc1ccc2[nH]cc(C3CCN(CCCCN4C(=O)CC(c5c[nH]c6ccc(OC)cc56)C4=O)CC3)c2c1	10.1016/j.ejmech.2019.111736
		44374227	168364	2	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	264	5	0	4	3.5	CN(C)CCSc1ncc(-c2ccccc2)s1	10.1016/j.bmcl.2003.11.050
		CHEMBL434477	168364	2	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	264	5	0	4	3.5	CN(C)CCSc1ncc(-c2ccccc2)s1	10.1016/j.bmcl.2003.11.050
		16117279	60136	0	None	-3235	7	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	398	5	3	5	3.7	CC(C)c1ccc(S(=O)(=O)c2n[nH]c3ccc(NC4CCNCC4)cc23)cc1	10.1016/j.bmc.2010.10.033
		CHEMBL1642886	60136	0	None	-3235	7	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	398	5	3	5	3.7	CC(C)c1ccc(S(=O)(=O)c2n[nH]c3ccc(NC4CCNCC4)cc23)cc1	10.1016/j.bmc.2010.10.033
		CHEMBL1739606	60136	0	None	-3235	7	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	398	5	3	5	3.7	CC(C)c1ccc(S(=O)(=O)c2n[nH]c3ccc(NC4CCNCC4)cc23)cc1	10.1016/j.bmc.2010.10.033
		121209051	164388	5	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	213	1	2	2	1.8	c1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		CHEMBL4213135	164388	5	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	213	1	2	2	1.8	c1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		162643049	183613	0	None	-22	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	10	1	4	5.1	CCC(C)c1ccc(NC(=O)CCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.ejmech.2020.112437
		CHEMBL4776078	183613	0	None	-22	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	10	1	4	5.1	CCC(C)c1ccc(NC(=O)CCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.ejmech.2020.112437
		CHEMBL4802282	183613	0	None	-22	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	10	1	4	5.1	CCC(C)c1ccc(NC(=O)CCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.ejmech.2020.112437
		121209051	164388	5	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	213	1	2	2	1.8	c1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		CHEMBL4213135	164388	5	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	213	1	2	2	1.8	c1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		134130846	142290	0	None	-3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	424	7	0	5	4.4	Cc1nc2ccccc2c(=O)n1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2016.12.039
		CHEMBL3885178	142290	0	None	-3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	424	7	0	5	4.4	Cc1nc2ccccc2c(=O)n1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2016.12.039
		11948707	166167	0	None	-158	13	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay	ChEMBL	373	7	0	8	0.6	COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1	10.1016/j.bmcl.2006.01.052
		CHEMBL426317	166167	0	None	-158	13	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay	ChEMBL	373	7	0	8	0.6	COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1	10.1016/j.bmcl.2006.01.052
		53377237	66389	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	6	0	6	4.2	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2011.04.060
		CHEMBL1851771	66389	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	6	0	6	4.2	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2011.04.060
		CHEMBL3215834	66389	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	6	0	6	4.2	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2011.04.060
		162661942	183711	3	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	425	7	2	5	4.2	COc1ccccc1N1CCN(CCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4778949	183711	3	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	425	7	2	5	4.2	COc1ccccc1N1CCN(CCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4803285	183711	3	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	425	7	2	5	4.2	COc1ccccc1N1CCN(CCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1	10.1016/j.ejmech.2020.112437
		44424656	85755	0	None	-1	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	470	9	0	10	1.4	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2007.05.017
		CHEMBL229124	85755	0	None	-1	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	470	9	0	10	1.4	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2007.05.017
		162668661	183741	0	None	-11	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	453	8	1	6	4.2	COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4789408	183741	0	None	-11	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	453	8	1	6	4.2	COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4803658	183741	0	None	-11	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	453	8	1	6	4.2	COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
		71462067	81169	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	460	9	1	4	5.7	CCOc1ccccc1C(=O)NC1CCN(CCSc2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2012.07.043
		CHEMBL2158035	81169	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	460	9	1	4	5.7	CCOc1ccccc1C(=O)NC1CCN(CCSc2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2012.07.043
		60165416	75296	0	None	-83	8	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	385	6	0	4	5.1	Clc1ccc(N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.ejmech.2012.03.042
		CHEMBL2037431	75296	0	None	-83	8	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	385	6	0	4	5.1	Clc1ccc(N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.ejmech.2012.03.042
		71459954	79182	0	None	-331	7	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cellsInhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	495	6	3	3	4.0	O=S(=O)(Cc1ccccc1I)Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1	10.1021/jm049243i
		CHEMBL2113386	79182	0	None	-331	7	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cellsInhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	495	6	3	3	4.0	O=S(=O)(Cc1ccccc1I)Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1	10.1021/jm049243i
		46206020	124600	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	251	2	0	1	4.1	Cc1ccccc1-c1ccccc1C1CCN(C)C1	nan
		CHEMBL3640606	124600	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	251	2	0	1	4.1	Cc1ccccc1-c1ccccc1C1CCN(C)C1	nan
		46206020	124600	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	251	2	0	1	4.1	Cc1ccccc1-c1ccccc1C1CCN(C)C1	nan
		CHEMBL3640606	124600	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	251	2	0	1	4.1	Cc1ccccc1-c1ccccc1C1CCN(C)C1	nan
		155541866	173049	0	None	-95	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	376	8	2	4	4.8	COc1ccc(-c2ccc(CNCCc3c[nH]c4ccc(OC)cc34)o2)cc1	10.1016/j.ejmech.2019.111857
		CHEMBL4519266	173049	0	None	-95	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	376	8	2	4	4.8	COc1ccc(-c2ccc(CNCCc3c[nH]c4ccc(OC)cc34)o2)cc1	10.1016/j.ejmech.2019.111857
		44393114	63636	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	318	7	2	4	4.3	C[C@H](Nc1cc(NCCc2ccccc2)ncn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		CHEMBL180087	63636	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	318	7	2	4	4.3	C[C@H](Nc1cc(NCCc2ccccc2)ncn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		76336177	106271	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	378	4	0	2	6.2	Cc1ccccc1-n1cc(CN2CC=C(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
		CHEMBL3121412	106271	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	378	4	0	2	6.2	Cc1ccccc1-n1cc(CN2CC=C(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
		CHEMBL3139015	106271	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	378	4	0	2	6.2	Cc1ccccc1-n1cc(CN2CC=C(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
		57399093	68439	0	None	9	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	443	9	0	4	4.9	CCN(CCCCCN1CCC2CCCCC2C1)S(=O)(=O)c1cccc2cccnc12	10.1016/j.bmc.2011.09.044
		CHEMBL1917360	68439	0	None	9	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	443	9	0	4	4.9	CCN(CCCCCN1CCC2CCCCC2C1)S(=O)(=O)c1cccc2cccnc12	10.1016/j.bmc.2011.09.044
		132938109	164303	0	None	8	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	500	9	2	5	4.2	O=S(=O)(NC1CCN(CC(O)COc2ccccc2-c2ccccc2)CC1)c1cccc(Cl)c1	10.1016/j.bmc.2017.03.057
		CHEMBL4212199	164303	0	None	8	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	500	9	2	5	4.2	O=S(=O)(NC1CCN(CC(O)COc2ccccc2-c2ccccc2)CC1)c1cccc(Cl)c1	10.1016/j.bmc.2017.03.057
		156019750	178015	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	254	2	0	2	3.1	CN(C)[C@H]1CCc2c(cccc2-c2cccn2C)C1	10.1016/j.bmc.2019.115262
		CHEMBL4646587	178015	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	254	2	0	2	3.1	CN(C)[C@H]1CCc2c(cccc2-c2cccn2C)C1	10.1016/j.bmc.2019.115262
		11666595	120532	0	None	-301	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1c(Cl)cccc1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3310115	120532	0	None	-301	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1c(Cl)cccc1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3545467	120532	0	None	-301	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1c(Cl)cccc1-2	10.1016/j.bmc.2014.05.027
		56945045	112061	0	None	-4	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	514	8	1	6	5.0	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
		CHEMBL3289956	112061	0	None	-4	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	514	8	1	6	5.0	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
		135458393	155596	4	None	-2	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	259	2	2	3	2.8	CC1NC(NCC(F)F)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.078
		CHEMBL404511	155596	4	None	-2	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	259	2	2	3	2.8	CC1NC(NCC(F)F)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.078
		24854108	157908	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	391	7	0	3	4.3	CCC1(CCCCN2CCN(c3ccccc3)CC2)C(=O)N(C)c2ccccc21	10.1021/jm070279v
		CHEMBL408429	157908	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	391	7	0	3	4.3	CCC1(CCCCN2CCN(c3ccccc3)CC2)C(=O)N(C)c2ccccc21	10.1021/jm070279v
		76335863	105009	0	None	22	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	487	11	1	5	4.5	COc1ccc(CNC(=O)CCOCCN2CCN(c3ccccc3-c3ccccc3C)CC2)cc1	10.1016/j.bmc.2014.01.016
		CHEMBL3113598	105009	0	None	22	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	487	11	1	5	4.5	COc1ccc(CNC(=O)CCOCCN2CCN(c3ccccc3-c3ccccc3C)CC2)cc1	10.1016/j.bmc.2014.01.016
		46203753	124544	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	280	4	1	4	2.6	COc1ccc(-c2ccccc2C#N)cc1OC1CNC1	nan
		CHEMBL3640552	124544	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	280	4	1	4	2.6	COc1ccc(-c2ccccc2C#N)cc1OC1CNC1	nan
		12741421	206759	8	None	-22	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	261	6	0	2	3.7	CCCN(CCC)[C@@H]1CCc2cccc(OC)c2C1	10.1021/jm030826m
		CHEMBL90053	206759	8	None	-22	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	261	6	0	2	3.7	CCCN(CCC)[C@@H]1CCc2cccc(OC)c2C1	10.1021/jm030826m
		46203753	124544	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	280	4	1	4	2.6	COc1ccc(-c2ccccc2C#N)cc1OC1CNC1	nan
		CHEMBL3640552	124544	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	280	4	1	4	2.6	COc1ccc(-c2ccccc2C#N)cc1OC1CNC1	nan
		24841480	183899	0	None	-165	20	Human	6.5	pKi	=	6.5	Binding	Antagonist activity at serotonin 5HT7 receptor (unknown origin) by PDSP assayAntagonist activity at serotonin 5HT7 receptor (unknown origin) by PDSP assay	ChEMBL	340	3	0	4	4.5	O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
		CHEMBL481153	183899	0	None	-165	20	Human	6.5	pKi	=	6.5	Binding	Antagonist activity at serotonin 5HT7 receptor (unknown origin) by PDSP assayAntagonist activity at serotonin 5HT7 receptor (unknown origin) by PDSP assay	ChEMBL	340	3	0	4	4.5	O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
		127052465	140731	0	None	-8	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	340	5	0	3	3.6	O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1	10.1016/j.bmc.2016.05.053
		CHEMBL3817911	140731	0	None	-8	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	340	5	0	3	3.6	O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1	10.1016/j.bmc.2016.05.053
		145977799	163643	0	None	-4	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	257	3	1	3	2.9	C[C@@H]1SC(c2ccccc2)=N[C@@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
		CHEMBL4204036	163643	0	None	-4	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	257	3	1	3	2.9	C[C@@H]1SC(c2ccccc2)=N[C@@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
		162669562	182702	0	None	-6	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	387	6	0	4	4.2	O=C(CCCN1C2CCC1CN(c1ccc(Cl)cn1)C2)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
		CHEMBL4789472	182702	0	None	-6	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	387	6	0	4	4.2	O=C(CCCN1C2CCC1CN(c1ccc(Cl)cn1)C2)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
		127052465	140731	0	None	-8	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	340	5	0	3	3.6	O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1	10.1016/j.bmc.2016.05.053
		CHEMBL3817911	140731	0	None	-8	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	340	5	0	3	3.6	O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1	10.1016/j.bmc.2016.05.053
		CHEMBL4748908	214035	1	None	-3	12	Human	6.5	pKi	=	6.5	Binding	GPCRScan assay: inhibition of 5-HT7AGPCRScan assay: inhibition of 5-HT7A	ChEMBL		None	None	None		CN1CCN(c2ccnc(NCCc3ccccc3)n2)CC1	10.6019/CHEMBL4800732
		90656716	112713	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	340	6	0	5	2.9	CN(CCN1CCN(c2ccccc2)CC1)c1cccc([N+](=O)[O-])c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262401	112713	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	340	6	0	5	2.9	CN(CCN1CCN(c2ccccc2)CC1)c1cccc([N+](=O)[O-])c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3304495	112713	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	340	6	0	5	2.9	CN(CCN1CCN(c2ccccc2)CC1)c1cccc([N+](=O)[O-])c1	10.1016/j.ejmech.2014.04.034
		57393877	68429	0	None	1	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	401	7	1	5	3.4	O=S(=O)(NCCCCN1CCc2sccc2C1)c1ccc2cccnc2c1	10.1016/j.bmc.2011.09.044
		CHEMBL1917350	68429	0	None	1	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	401	7	1	5	3.4	O=S(=O)(NCCCCN1CCc2sccc2C1)c1ccc2cccnc2c1	10.1016/j.bmc.2011.09.044
		71458516	81165	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	465	8	1	4	5.4	O=C(NCC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc2ccccc2n1	10.1016/j.ejmech.2012.07.043
		CHEMBL2158031	81165	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	465	8	1	4	5.4	O=C(NCC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc2ccccc2n1	10.1016/j.ejmech.2012.07.043
		57396857	71568	0	None	6	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	472	9	1	5	4.2	O=S(=O)(NCCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
		CHEMBL1949971	71568	0	None	6	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	472	9	1	5	4.2	O=S(=O)(NCCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
		CHEMBL1963101	71568	0	None	6	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	472	9	1	5	4.2	O=S(=O)(NCCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
		CHEMBL4748908	214035	1	None	-3	12	Human	6.5	pKi	=	6.5	Binding	GPCRScan assay: inhibition of 5-HT7AGPCRScan assay: inhibition of 5-HT7A	ChEMBL		None	None	None		CN1CCN(c2ccnc(NCCc3ccccc3)n2)CC1	10.6019/CHEMBL4800732
		57390335	68418	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	387	9	1	4	2.5	NCCCN(CCCN1CCc2ccccc2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2011.09.044
		CHEMBL1917339	68418	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	387	9	1	4	2.5	NCCCN(CCCN1CCc2ccccc2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2011.09.044
		162669562	182702	0	None	-6	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	387	6	0	4	4.2	O=C(CCCN1C2CCC1CN(c1ccc(Cl)cn1)C2)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
		CHEMBL4789472	182702	0	None	-6	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	387	6	0	4	4.2	O=C(CCCN1C2CCC1CN(c1ccc(Cl)cn1)C2)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
		57403841	71554	0	None	4	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc2ncccc2c1	10.1016/j.bmc.2011.12.039
		CHEMBL1949968	71554	0	None	4	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc2ncccc2c1	10.1016/j.bmc.2011.12.039
		CHEMBL1963030	71554	0	None	4	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc2ncccc2c1	10.1016/j.bmc.2011.12.039
		42618273	91200	0	None	-223	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	461	3	0	4	4.1	O=C1C2CC=CCC2C(=O)N1C1CCC(N2CCN(c3cccc(C(F)(F)F)c3)CC2)CC1	10.1016/j.bmc.2007.07.029
		CHEMBL239899	91200	0	None	-223	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	461	3	0	4	4.1	O=C1C2CC=CCC2C(=O)N1C1CCC(N2CCN(c3cccc(C(F)(F)F)c3)CC2)CC1	10.1016/j.bmc.2007.07.029
		10020040	99968	0	None	-72	3	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	338	4	1	4	3.6	CSc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1	10.1016/s0960-894x(01)00241-4
		CHEMBL28651	99968	0	None	-72	3	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	338	4	1	4	3.6	CSc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1	10.1016/s0960-894x(01)00241-4
		136118653	93054	0	None	-6	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1/N/C(=C/c2c[nH]c3ccc(Br)cc23)C(=O)N1C	10.1016/j.bmc.2013.09.011
		CHEMBL2442267	93054	0	None	-6	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1/N/C(=C/c2c[nH]c3ccc(Br)cc23)C(=O)N1C	10.1016/j.bmc.2013.09.011
		155544811	176551	0	None	-5	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	447	8	0	3	5.8	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4567345	176551	0	None	-5	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	447	8	0	3	5.8	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4597228	176551	0	None	-5	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	447	8	0	3	5.8	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmc.2019.06.028
		60165411	75357	0	None	-93	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	381	7	0	7	3.3	O=C(CCCCN1CCN(c2ncccn2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
		CHEMBL2037529	75357	0	None	-93	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	381	7	0	7	3.3	O=C(CCCCN1CCN(c2ncccn2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
		71460454	81364	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	411	9	2	5	2.9	CCOc1ccccc1C(=O)NC1CCN(CCOc2cccc(NC(C)=O)c2)C1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159312	81364	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	411	9	2	5	2.9	CCOc1ccccc1C(=O)NC1CCN(CCOc2cccc(NC(C)=O)c2)C1	10.1016/j.ejmech.2012.07.043
		24768522	142576	0	None	2	3	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	462	9	2	4	4.5	CC(=O)Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
		CHEMBL389110	142576	0	None	2	3	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	462	9	2	4	4.5	CC(=O)Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
		12741423	107064	11	None	-120	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	261	6	0	2	3.7	CCCN(CCC)[C@H]1CCc2cccc(OC)c2C1	10.1021/jm030826m
		CHEMBL315684	107064	11	None	-120	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	261	6	0	2	3.7	CCCN(CCC)[C@H]1CCc2cccc(OC)c2C1	10.1021/jm030826m
		56852956	112043	1	None	-87	9	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by PDSP assayDisplacement of [3H]LSD from human 5-HT7 receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
		CHEMBL3289656	112043	1	None	-87	9	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by PDSP assayDisplacement of [3H]LSD from human 5-HT7 receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
		44517733	195212	0	None	30	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	431	7	3	5	1.6	COc1ccccc1N1CCN(C(=N)NCCNS(=O)(=O)c2cccc(C)c2)CC1	10.1016/j.bmcl.2009.06.038
		CHEMBL550740	195212	0	None	30	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	431	7	3	5	1.6	COc1ccccc1N1CCN(C(=N)NCCNS(=O)(=O)c2cccc(C)c2)CC1	10.1016/j.bmcl.2009.06.038
		162648426	179960	0	None	-7	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	373	6	0	3	4.6	Fc1ccc(CCCCN2C3CCC2CN(c2ccc(Cl)cn2)C3)cc1	10.1016/j.bmc.2020.115943
		CHEMBL4746695	179960	0	None	-7	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	373	6	0	3	4.6	Fc1ccc(CCCCN2C3CCC2CN(c2ccc(Cl)cn2)C3)cc1	10.1016/j.bmc.2020.115943
		168299277	192695	0	None	281	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant	ChEMBL	404	8	0	5	4.2	CCOCC(Oc1c(C)cccc1Cl)N1CCN(c2ccccc2OC)CC1	10.1016/j.bmcl.2021.128275
		CHEMBL5219333	192695	0	None	281	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant	ChEMBL	404	8	0	5	4.2	CCOCC(Oc1c(C)cccc1Cl)N1CCN(c2ccccc2OC)CC1	10.1016/j.bmcl.2021.128275
		44460738	105453	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	291	3	0	3	2.9	CN1CCCN(CCn2ccc3ccc(Cl)cc32)CC1	10.1016/s0960-894x(02)00438-9
		CHEMBL312049	105453	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	291	3	0	3	2.9	CN1CCCN(CCn2ccc3ccc(Cl)cc32)CC1	10.1016/s0960-894x(02)00438-9
		76332579	106275	0	None	16	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	417	4	0	3	6.1	c1ccc(N2CCN(Cc3cn(-c4cccc5ccccc45)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
		CHEMBL3121423	106275	0	None	16	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	417	4	0	3	6.1	c1ccc(N2CCN(Cc3cn(-c4cccc5ccccc45)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
		CHEMBL3139019	106275	0	None	16	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	417	4	0	3	6.1	c1ccc(N2CCN(Cc3cn(-c4cccc5ccccc45)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
		145976618	163779	0	None	8	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	468	8	1	4	4.7	CC(COc1ccccc1-c1ccccc1)N1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2017.03.057
		CHEMBL4205806	163779	0	None	8	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	468	8	1	4	4.7	CC(COc1ccccc1-c1ccccc1)N1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2017.03.057
		90654836	112694	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	464	9	0	5	3.8	COc1ccccc1N1CCN(CCCCCN2C(=O)N(C)C(=O)C2(C)c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
		CHEMBL3233667	112694	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	464	9	0	5	3.8	COc1ccccc1N1CCN(CCCCCN2C(=O)N(C)C(=O)C2(C)c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
		CHEMBL3304308	112694	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	464	9	0	5	3.8	COc1ccccc1N1CCN(CCCCCN2C(=O)N(C)C(=O)C2(C)c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
		155557134	174537	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	493	10	0	5	5.1	CCOc1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/j.bmcl.2019.06.029
		CHEMBL4555890	174537	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	493	10	0	5	5.1	CCOc1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/j.bmcl.2019.06.029
		11186985	123846	0	None	-11	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	307	6	0	1	5.3	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2019.115262
		CHEMBL362540	123846	0	None	-11	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	307	6	0	1	5.3	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2019.115262
		134141985	147176	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	432	6	0	6	4.4	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)cc2c1OCO2	10.1016/j.ejmech.2016.07.029
		CHEMBL3927929	147176	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	432	6	0	6	4.4	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)cc2c1OCO2	10.1016/j.ejmech.2016.07.029
		66801673	112074	0	None	8	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	468	7	1	6	3.6	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
		CHEMBL3289969	112074	0	None	8	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	468	7	1	6	3.6	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
		66801251	112120	0	None	-13	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	507	7	1	6	5.4	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
		CHEMBL3290013	112120	0	None	-13	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	507	7	1	6	5.4	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
		122178704	121370	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	397	6	0	5	4.6	CCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
		CHEMBL3581249	121370	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	397	6	0	5	4.6	CCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
		44401106	124327	0	None	-52	9	Human	7.5	pKi	=	7.5	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL363581	124327	0	None	-52	9	Human	7.5	pKi	=	7.5	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		76284452	105005	0	None	16	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	492	11	1	6	3.7	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccc(F)nc3)CC2)cc1	10.1016/j.bmc.2014.01.016
		CHEMBL3113594	105005	0	None	16	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	492	11	1	6	3.7	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccc(F)nc3)CC2)cc1	10.1016/j.bmc.2014.01.016
		46204423	124563	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	259	3	1	2	3.4	Clc1ccccc1-c1cccc(OC2CNC2)c1	nan
		CHEMBL3640570	124563	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	259	3	1	2	3.4	Clc1ccccc1-c1cccc(OC2CNC2)c1	nan
		46204423	124563	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	259	3	1	2	3.4	Clc1ccccc1-c1cccc(OC2CNC2)c1	nan
		CHEMBL3640570	124563	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	259	3	1	2	3.4	Clc1ccccc1-c1cccc(OC2CNC2)c1	nan
		72550200	114076	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	475	10	1	4	5.1	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2cccc(F)c2)CC1	10.1016/j.bmc.2014.07.026
		CHEMBL3326980	114076	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	475	10	1	4	5.1	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2cccc(F)c2)CC1	10.1016/j.bmc.2014.07.026
		72550423	114077	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	475	10	1	4	5.1	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccc(F)cc2)CC1	10.1016/j.bmc.2014.07.026
		CHEMBL3326981	114077	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	475	10	1	4	5.1	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccc(F)cc2)CC1	10.1016/j.bmc.2014.07.026
		25107651	187710	0	None	-4	3	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	412	10	1	5	3.8	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	10.1021/jm800615e
		CHEMBL495321	187710	0	None	-4	3	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	412	10	1	5	3.8	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	10.1021/jm800615e
		44448054	94785	0	None	-6	6	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	276	0	1	2	2.8	CN1CCc2ccc3[nH]c(=O)c4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
		CHEMBL253318	94785	0	None	-6	6	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	276	0	1	2	2.8	CN1CCc2ccc3[nH]c(=O)c4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
		56852956	112043	1	None	-87	9	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by PDSP assayDisplacement of [3H]LSD from human 5-HT7 receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
		CHEMBL3289656	112043	1	None	-87	9	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by PDSP assayDisplacement of [3H]LSD from human 5-HT7 receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
		44404394	132815	0	None	-30	7	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	443	4	1	5	3.5	COc1ccc(NC(=O)N2CCN(c3ccccc3Cl)CC2)cc1N1CCN(C)CC1	10.1016/j.bmcl.2005.07.024
		CHEMBL370128	132815	0	None	-30	7	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	443	4	1	5	3.5	COc1ccc(NC(=O)N2CCN(c3ccccc3Cl)CC2)cc1N1CCN(C)CC1	10.1016/j.bmcl.2005.07.024
		168290061	191334	0	None	-69	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	424	8	3	8	2.7	Nc1nc(N)nc(NCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n1	10.1016/j.ejmech.2021.113931
		CHEMBL5191557	191334	0	None	-69	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	424	8	3	8	2.7	Nc1nc(N)nc(NCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n1	10.1016/j.ejmech.2021.113931
		162643558	183616	0	None	-8	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	397	9	2	5	3.0	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4777499	183616	0	None	-8	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	397	9	2	5	3.0	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4802310	183616	0	None	-8	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	397	9	2	5	3.0	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
		127026119	137735	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	408	8	1	5	2.7	COc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
		CHEMBL3759120	137735	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	408	8	1	5	2.7	COc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
		155562834	175206	0	None	-10	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	450	8	0	5	4.1	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2019.06.029
		CHEMBL4571077	175206	0	None	-10	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	450	8	0	5	4.1	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2019.06.029
		72198011	89845	0	None	-158	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	498	8	2	4	5.2	COc1ccc2[nH]cc(C3CCN(CCCCN4C(=O)CC(c5c[nH]c6ccccc56)C4=O)CC3)c2c1	10.1016/j.ejmech.2019.111736
		CHEMBL2377591	89845	0	None	-158	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	498	8	2	4	5.2	COc1ccc2[nH]cc(C3CCN(CCCCN4C(=O)CC(c5c[nH]c6ccccc56)C4=O)CC3)c2c1	10.1016/j.ejmech.2019.111736
		72198011	89845	0	None	-158	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	498	8	2	4	5.2	COc1ccc2[nH]cc(C3CCN(CCCCN4C(=O)CC(c5c[nH]c6ccccc56)C4=O)CC3)c2c1	10.1016/j.ejmech.2013.02.033
		CHEMBL2377591	89845	0	None	-158	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	498	8	2	4	5.2	COc1ccc2[nH]cc(C3CCN(CCCCN4C(=O)CC(c5c[nH]c6ccccc56)C4=O)CC3)c2c1	10.1016/j.ejmech.2013.02.033
		13069622	120616	0	None	-31	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	410	7	0	8	1.4	Cn1c(=O)c2c(ncn2CCCCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		CHEMBL3360999	120616	0	None	-31	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	410	7	0	8	1.4	Cn1c(=O)c2c(ncn2CCCCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		CHEMBL3546120	120616	0	None	-31	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	410	7	0	8	1.4	Cn1c(=O)c2c(ncn2CCCCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		168276829	190125	0	None	-32	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	501	6	0	7	4.6	COc1cc2ncnc(N3CCC(CN4CCN(c5cccc(Cl)c5Cl)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
		CHEMBL5173329	190125	0	None	-32	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	501	6	0	7	4.6	COc1cc2ncnc(N3CCC(CN4CCN(c5cccc(Cl)c5Cl)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
		117209918	186410	1	None	3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
		CHEMBL4876036	186410	1	None	3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
		155534153	176250	0	None	-120	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	366	4	2	5	3.4	CCc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2ccccc2)c2ccccc12	10.1016/j.ejmech.2019.06.001
		CHEMBL4469860	176250	0	None	-120	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	366	4	2	5	3.4	CCc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2ccccc2)c2ccccc12	10.1016/j.ejmech.2019.06.001
		CHEMBL4594878	176250	0	None	-120	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	366	4	2	5	3.4	CCc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2ccccc2)c2ccccc12	10.1016/j.ejmech.2019.06.001
		117209918	186410	1	None	3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
		CHEMBL4876036	186410	1	None	3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
		168279625	191007	0	None	-66	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	433	5	0	6	3.5	O=c1n(Cc2ccc(CN3CCN(c4cccc(Cl)c4)CC3)cc2)nc2ccccn12	10.1016/j.ejmech.2022.114319
		CHEMBL5186688	191007	0	None	-66	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	433	5	0	6	3.5	O=c1n(Cc2ccc(CN3CCN(c4cccc(Cl)c4)CC3)cc2)nc2ccccn12	10.1016/j.ejmech.2022.114319
		71461049	82975	0	None	-204	5	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	364	6	0	4	4.9	CCCN1CCC(COc2nc3c(OC)cccc3c3ccccc23)CC1	10.1021/jm300943r
		CHEMBL2181187	82975	0	None	-204	5	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	364	6	0	4	4.9	CCCN1CCC(COc2nc3c(OC)cccc3c3ccccc23)CC1	10.1021/jm300943r
		118626208	165553	0	None	-57	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	7	3.4	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4241830	165553	0	None	-57	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	7	3.4	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/j.ejmech.2018.01.002
		5640104	117939	11	None	1	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	429	4	1	5	3.4	NC(=O)C1CCN(c2c(S(=O)(=O)c3ccccc3)cnc3ccc(Cl)cc23)CC1	10.1016/j.bmcl.2015.03.049
		CHEMBL3403342	117939	11	None	1	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	429	4	1	5	3.4	NC(=O)C1CCN(c2c(S(=O)(=O)c3ccccc3)cnc3ccc(Cl)cc23)CC1	10.1016/j.bmcl.2015.03.049
		74538690	143064	0	None	10	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	511	10	1	4	5.2	O=C(CCOCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccc(C(F)(F)F)cc1	10.1016/j.ejmech.2016.05.005
		CHEMBL3895172	143064	0	None	10	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	511	10	1	4	5.2	O=C(CCOCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccc(C(F)(F)F)cc1	10.1016/j.ejmech.2016.05.005
		164625711	186332	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	481	7	0	5	3.8	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmcl.2021.128028
		CHEMBL4874914	186332	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	481	7	0	5	3.8	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmcl.2021.128028
		155535827	172117	0	None	-2	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	450	6	1	2	6.5	Fc1cccc(-c2cc(F)ccc2OCCN2CCC(c3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.bmcl.2019.126769
		CHEMBL4472767	172117	0	None	-2	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	450	6	1	2	6.5	Fc1cccc(-c2cc(F)ccc2OCCN2CCC(c3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.bmcl.2019.126769
		11278059	57015	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	302	3	1	2	4.2	Cc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
		CHEMBL1644275	57015	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	302	3	1	2	4.2	Cc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
		44439393	91809	0	None	2754	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	308	3	2	2	4.3	CSc1ccccc1CC1NCCc2c1[nH]c1ccccc21	10.1016/j.bmcl.2007.01.093
		CHEMBL241279	91809	0	None	2754	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	308	3	2	2	4.3	CSc1ccccc1CC1NCCc2c1[nH]c1ccccc21	10.1016/j.bmcl.2007.01.093
		44421337	138127	0	None	7	2	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor incubated for 60 mins by competitive binding assayDisplacement of [3H]LSD from rat cloned 5HT7 receptor incubated for 60 mins by competitive binding assay	ChEMBL	437	8	1	5	3.8	COc1ccccc1N1CCN(CCCC(=O)NC2CCCc3c(OC)cccc32)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL376662	138127	0	None	7	2	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor incubated for 60 mins by competitive binding assayDisplacement of [3H]LSD from rat cloned 5HT7 receptor incubated for 60 mins by competitive binding assay	ChEMBL	437	8	1	5	3.8	COc1ccccc1N1CCN(CCCC(=O)NC2CCCc3c(OC)cccc32)CC1	10.1016/j.ejmech.2020.112437
		44421337	138127	0	None	7	2	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	8	1	5	3.8	COc1ccccc1N1CCN(CCCC(=O)NC2CCCc3c(OC)cccc32)CC1	10.1021/jm049702f
		CHEMBL376662	138127	0	None	7	2	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	8	1	5	3.8	COc1ccccc1N1CCN(CCCC(=O)NC2CCCc3c(OC)cccc32)CC1	10.1021/jm049702f
		44401105	69576	0	None	-3	9	Human	7.5	pKi	=	7.5	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	373	2	0	3	4.7	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Br)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL193435	69576	0	None	-3	9	Human	7.5	pKi	=	7.5	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	373	2	0	3	4.7	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Br)cc3[C@H]2O1	10.1021/jm049632c
		132547277	142146	0	None	-4	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	424	7	0	5	4.4	Cc1nc2ccccc2c(=O)n1CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2016.12.039
		CHEMBL3883542	142146	0	None	-4	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	424	7	0	5	4.4	Cc1nc2ccccc2c(=O)n1CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2016.12.039
		44324640	207422	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	281	3	2	4	3.0	COc1cccc(-c2cccc(NC3=NCCN3)c2C)c1	10.1016/s0960-894x(02)00925-3
		CHEMBL94017	207422	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	281	3	2	4	3.0	COc1cccc(-c2cccc(NC3=NCCN3)c2C)c1	10.1016/s0960-894x(02)00925-3
		60165535	75350	0	None	-6	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	322	5	0	3	4.7	c1ccc2c(c1)CCN(CCCCc1nc3ccccc3s1)C2	10.1016/j.ejmech.2012.03.042
		CHEMBL2037522	75350	0	None	-6	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	322	5	0	3	4.7	c1ccc2c(c1)CCN(CCCCc1nc3ccccc3s1)C2	10.1016/j.ejmech.2012.03.042
		162661940	181879	0	None	12	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	470	8	1	5	4.7	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccc(Cl)c(F)c3)CC2)cc1	10.1016/j.ejmech.2020.112395
		CHEMBL4778946	181879	0	None	12	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	470	8	1	5	4.7	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccc(Cl)c(F)c3)CC2)cc1	10.1016/j.ejmech.2020.112395
		118728523	117718	0	None	-5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	0	5	4.0	O=c1c2ccccc2ncn1CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2015.02.042
		CHEMBL3401486	117718	0	None	-5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	0	5	4.0	O=c1c2ccccc2ncn1CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2015.02.042
		42625269	186808	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	292	3	0	2	2.6	O=C1Cc2ccccc2N1CCN1CCc2ccccc2C1	10.1021/jm8014553
		CHEMBL489256	186808	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	292	3	0	2	2.6	O=C1Cc2ccccc2N1CCN1CCc2ccccc2C1	10.1021/jm8014553
		44439388	91773	0	None	7	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	306	3	1	3	3.6	COc1cccc(C2=NCCc3c2[nH]c2ccc(OC)cc32)c1	10.1016/j.bmcl.2007.01.093
		CHEMBL241082	91773	0	None	7	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	306	3	1	3	3.6	COc1cccc(C2=NCCc3c2[nH]c2ccc(OC)cc32)c1	10.1016/j.bmcl.2007.01.093
		71450550	83807	0	None	-7	16	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	309	4	1	3	2.0	COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
		CHEMBL2205836	83807	0	None	-7	16	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	309	4	1	3	2.0	COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
		1355	2011	88	None	-21	16	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm3003679
		142	2011	88	None	-21	16	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm3003679
		CHEMBL478	2011	88	None	-21	16	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm3003679
		DB12110	2011	88	None	-21	16	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm3003679
		57401516	68399	0	None	-1	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	484	7	1	5	3.0	CN1C(=O)N(CC(O)CN2CCN(c3ccccc3)CC2)C(c2ccccc2)(c2ccccc2)C1=O	10.1016/j.ejmech.2014.01.065
		CHEMBL1916746	68399	0	None	-1	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	484	7	1	5	3.0	CN1C(=O)N(CC(O)CN2CCN(c3ccccc3)CC2)C(c2ccccc2)(c2ccccc2)C1=O	10.1016/j.ejmech.2014.01.065
		156009734	177166	0	None	1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	393	5	2	4	3.7	COc1cc2c3c(c1OCC1CC1)-c1cc(NC(N)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
		CHEMBL4634426	177166	0	None	1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	393	5	2	4	3.7	COc1cc2c3c(c1OCC1CC1)-c1cc(NC(N)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
		9821832	126456	1	None	-4	2	Rat	6.5	pKi	=	6.5	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	391	6	0	5	2.7	COc1ccccc1N1CCN(C/C=C\CN2C(=O)c3ccccc3C2=O)CC1	10.1016/j.bmcl.2004.09.029
		CHEMBL365201	126456	1	None	-4	2	Rat	6.5	pKi	=	6.5	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	391	6	0	5	2.7	COc1ccccc1N1CCN(C/C=C\CN2C(=O)c3ccccc3C2=O)CC1	10.1016/j.bmcl.2004.09.029
		162671253	183758	0	None	-9	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	9	1	4	4.8	CCC(C)c1ccc(NC(=O)CCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.ejmech.2020.112437
		CHEMBL4792933	183758	0	None	-9	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	9	1	4	4.8	CCC(C)c1ccc(NC(=O)CCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.ejmech.2020.112437
		CHEMBL4803811	183758	0	None	-9	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	9	1	4	4.8	CCC(C)c1ccc(NC(=O)CCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.ejmech.2020.112437
		168286403	191744	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	501	6	0	7	4.6	COc1cc2ncnc(N3CCC(CN4CCN(c5ccc(Cl)c(Cl)c5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
		CHEMBL5197377	191744	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	501	6	0	7	4.6	COc1cc2ncnc(N3CCC(CN4CCN(c5ccc(Cl)c(Cl)c5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
		43229249	140817	1	None	-91	8	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	279	5	0	2	3.7	O=C(CCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818989	140817	1	None	-91	8	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	279	5	0	2	3.7	O=C(CCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2016.05.053
		57402951	70468	0	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	413	6	0	5	5.1	O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
		CHEMBL1946258	70468	0	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	413	6	0	5	5.1	O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
		11261423	142399	0	None	7	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	445	8	2	4	4.4	O=C(CCCCCN1CCN(c2nc3ccccc3[nH]2)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
		CHEMBL388970	142399	0	None	7	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	445	8	2	4	4.4	O=C(CCCCCN1CCN(c2nc3ccccc3[nH]2)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
		118728507	117704	0	None	-9	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	396	6	1	5	3.7	Cc1sc2nc(CCCCN3CCN(c4ccccc4)CC3)[nH]c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
		CHEMBL3401470	117704	0	None	-9	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	396	6	1	5	3.7	Cc1sc2nc(CCCCN3CCN(c4ccccc4)CC3)[nH]c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
		43229249	140817	1	None	-91	8	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	279	5	0	2	3.7	O=C(CCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818989	140817	1	None	-91	8	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	279	5	0	2	3.7	O=C(CCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2016.05.053
		44393074	64277	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	386	8	3	7	3.4	C[C@@H](Nc1nc(N)nc(NCCOc2ccc(F)cc2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
		CHEMBL180946	64277	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	386	8	3	7	3.4	C[C@@H](Nc1nc(N)nc(NCCOc2ccc(F)cc2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
		137644790	158068	0	None	3	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	5.2	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
		CHEMBL4086211	158068	0	None	3	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	5.2	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
		162664377	182198	0	None	75	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	533	9	1	6	6.3	COc1ccc(-c2ccccc2C2CCN(C[C@@H](O)COc3ccc(-c4cn5ccccc5n4)cc3)CC2)cc1	10.1016/j.ejmech.2020.112395
		CHEMBL4782879	182198	0	None	75	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	533	9	1	6	6.3	COc1ccc(-c2ccccc2C2CCN(C[C@@H](O)COc3ccc(-c4cn5ccccc5n4)cc3)CC2)cc1	10.1016/j.ejmech.2020.112395
		156012551	177337	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	470	8	0	5	5.8	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
		CHEMBL4637294	177337	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	470	8	0	5	5.8	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
		138691321	174519	0	None	18	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	355	2	1	2	3.8	CCn1cncc1-c1c[nH]c2c(F)cc(I)cc12	10.1016/j.ejmech.2019.03.017
		CHEMBL4555349	174519	0	None	18	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	355	2	1	2	3.8	CCn1cncc1-c1c[nH]c2c(F)cc(I)cc12	10.1016/j.ejmech.2019.03.017
		127039754	136682	0	None	10	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	454	8	1	4	4.3	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc(F)c1	10.1039/C5MD00166H
		CHEMBL3740302	136682	0	None	10	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	454	8	1	4	4.3	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc(F)c1	10.1039/C5MD00166H
		164619290	185805	0	None	-2	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	463	7	0	5	4.0	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2cccc3ccccc23)CC1	10.1016/j.bmcl.2021.128028
		CHEMBL4866981	185805	0	None	-2	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	463	7	0	5	4.0	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2cccc3ccccc23)CC1	10.1016/j.bmcl.2021.128028
		57391624	71569	0	None	3	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	457	8	1	4	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cccc2ccccc12	10.1016/j.bmc.2011.12.039
		CHEMBL1949972	71569	0	None	3	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	457	8	1	4	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cccc2ccccc12	10.1016/j.bmc.2011.12.039
		CHEMBL1963102	71569	0	None	3	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	457	8	1	4	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cccc2ccccc12	10.1016/j.bmc.2011.12.039
		11404955	57026	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	336	3	0	2	4.8	CN1CCc2c(c(-c3ccc(Cl)cc3)cn2Cc2ccccc2)C1	10.1016/j.bmcl.2010.11.078
		CHEMBL1644488	57026	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	336	3	0	2	4.8	CN1CCc2c(c(-c3ccc(Cl)cc3)cn2Cc2ccccc2)C1	10.1016/j.bmcl.2010.11.078
		44439391	145119	0	None	52	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	336	3	2	4	3.3	COc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccc2c(c1)OCO2	10.1016/j.bmcl.2007.01.093
		CHEMBL391190	145119	0	None	52	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	336	3	2	4	3.3	COc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccc2c(c1)OCO2	10.1016/j.bmcl.2007.01.093
		118709752	113542	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	362	8	0	2	4.6	O=C1Cc2ccccc2N1CCCCCCCN1CCc2ccccc2C1	10.1021/jm500880c
		CHEMBL3321793	113542	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	362	8	0	2	4.6	O=C1Cc2ccccc2N1CCCCCCCN1CCc2ccccc2C1	10.1021/jm500880c
		11463465	66878	0	None	-7	2	Rat	7.4	pKi	=	7.4	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	391	6	0	5	2.7	COc1ccccc1N1CCN(C/C=C/CN2C(=O)c3ccccc3C2=O)CC1	10.1016/j.bmcl.2004.09.029
		CHEMBL186334	66878	0	None	-7	2	Rat	7.4	pKi	=	7.4	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	391	6	0	5	2.7	COc1ccccc1N1CCN(C/C=C/CN2C(=O)c3ccccc3C2=O)CC1	10.1016/j.bmcl.2004.09.029
		10807321	99169	0	None	3	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	343	1	2	3	4.5	CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2c(O)cccc2O)c1-3	10.1021/jm0108505
		CHEMBL281273	99169	0	None	3	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	343	1	2	3	4.5	CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2c(O)cccc2O)c1-3	10.1021/jm0108505
		118713587	114371	0	None	25	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	367	6	0	5	3.7	O=c1sc2ccccc2n1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
		CHEMBL3331255	114371	0	None	25	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	367	6	0	5	3.7	O=c1sc2ccccc2n1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
		134151729	153445	0	None	5	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	455	10	1	3	5.7	C[C@H]1CN(c2ccccc2-c2ccccc2)CCN1CCCCCC(=O)NCc1ccccc1	10.1016/j.ejmech.2016.05.005
		CHEMBL3979307	153445	0	None	5	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	455	10	1	3	5.7	C[C@H]1CN(c2ccccc2-c2ccccc2)CCN1CCCCCC(=O)NCc1ccccc1	10.1016/j.ejmech.2016.05.005
		72550196	114075	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	475	10	1	4	5.1	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2F)CC1	10.1016/j.bmc.2014.07.026
		CHEMBL3326979	114075	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	475	10	1	4	5.1	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2F)CC1	10.1016/j.bmc.2014.07.026
		155524374	170920	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	426	6	0	4	3.2	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2016.06.080
		CHEMBL4455118	170920	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	426	6	0	4	3.2	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2016.06.080
		11429236	125418	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	390	8	1	5	2.4	COc1ccc(S(=O)(=O)NCCCN2CCc3cc(OC)ccc3C2)cc1	10.1021/jm049743b
		CHEMBL364557	125418	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	390	8	1	5	2.4	COc1ccc(S(=O)(=O)NCCCN2CCc3cc(OC)ccc3C2)cc1	10.1021/jm049743b
		57395597	68409	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	410	7	1	4	3.6	COc1cccc2c1CCN(CCCNS(=O)(=O)c1cccc3ccccc13)C2	10.1016/j.bmc.2011.09.044
		CHEMBL1917330	68409	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	410	7	1	4	3.6	COc1cccc2c1CCN(CCCNS(=O)(=O)c1cccc3ccccc13)C2	10.1016/j.bmc.2011.09.044
		145964159	164329	0	None	-77	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	273	3	2	4	2.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
		CHEMBL4212435	164329	0	None	-77	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	273	3	2	4	2.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
		44439410	147289	0	None	5	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	280	4	1	2	3.5	CN(/C=N/c1ccc2c(c1)C(O)CC2)Cc1ccccc1	10.1016/j.bmcl.2007.01.093
		CHEMBL392888	147289	0	None	5	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	280	4	1	2	3.5	CN(/C=N/c1ccc2c(c1)C(O)CC2)Cc1ccccc1	10.1016/j.bmcl.2007.01.093
		44439407	167415	0	None	-11	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	424	8	0	4	5.9	CCCCSC1CCc2ccc(/N=C/N3CCc4cc(OC)c(OC)cc4C3)cc21	10.1016/j.bmcl.2007.01.093
		CHEMBL429644	167415	0	None	-11	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	424	8	0	4	5.9	CCCCSC1CCc2ccc(/N=C/N3CCc4cc(OC)c(OC)cc4C3)cc21	10.1016/j.bmcl.2007.01.093
		71459604	83793	0	None	-6	14	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	309	4	1	3	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1	10.1016/j.bmcl.2012.08.046
		CHEMBL2205811	83793	0	None	-6	14	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	309	4	1	3	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1	10.1016/j.bmcl.2012.08.046
		145979626	166541	0	None	1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	454	6	2	5	1.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(=O)c3ccccc3)CC2)C1=O	10.1039/C8MD00168E
		CHEMBL4279397	166541	0	None	1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	454	6	2	5	1.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(=O)c3ccccc3)CC2)C1=O	10.1039/C8MD00168E
		118736371	118943	0	None	-9	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	483	6	0	9	2.3	Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2015.04.046
		CHEMBL3423335	118943	0	None	-9	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	483	6	0	9	2.3	Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2015.04.046
		118724643	120602	0	None	-8	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	353	4	0	7	0.9	Cn1c(=O)c2c(ncn2CCCN2CCc3ccccc3C2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		CHEMBL3361002	120602	0	None	-8	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	353	4	0	7	0.9	Cn1c(=O)c2c(ncn2CCCN2CCc3ccccc3C2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		CHEMBL3545933	120602	0	None	-8	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	353	4	0	7	0.9	Cn1c(=O)c2c(ncn2CCCN2CCc3ccccc3C2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		122483213	138093	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3764178	138093	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3765841	138093	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		135367399	163835	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1ccccc1-c1noc2c1CCNCC2	10.1021/acs.jmedchem.8b00642
		CHEMBL4206411	163835	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1ccccc1-c1noc2c1CCNCC2	10.1021/acs.jmedchem.8b00642
		118736370	118942	0	None	-50	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	483	7	0	9	2.3	Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccc(Cl)cc5)CC4)ccn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
		CHEMBL3423334	118942	0	None	-50	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	483	7	0	9	2.3	Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccc(Cl)cc5)CC4)ccn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
		122483213	138093	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3764178	138093	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3765841	138093	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		27620	140818	13	None	-158	8	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	297	5	0	2	3.8	O=C(CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818994	140818	13	None	-158	8	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	297	5	0	2	3.8	O=C(CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
		11209976	123173	0	None	1	3	Rat	6.4	pKi	=	6.4	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	339	7	0	3	4.8	CCCN(CCC)[C@@H]1COc2c(cccc2-c2ccccc2OC)C1	10.1021/jm0498102
		CHEMBL361287	123173	0	None	1	3	Rat	6.4	pKi	=	6.4	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	339	7	0	3	4.8	CCCN(CCC)[C@@H]1COc2c(cccc2-c2ccccc2OC)C1	10.1021/jm0498102
		71455894	83802	0	None	-3	12	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	325	4	1	4	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC	10.1016/j.bmcl.2012.08.046
		CHEMBL2205827	83802	0	None	-3	12	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	325	4	1	4	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC	10.1016/j.bmcl.2012.08.046
		71455894	83802	0	None	-3	12	Human	5.4	pKi	=	5.4	Binding	Inhibition of 5-HT7 receptor (unknown origin) by PDSP assayInhibition of 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	325	4	1	4	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC	10.1016/j.bmc.2013.07.045
		CHEMBL2205827	83802	0	None	-3	12	Human	5.4	pKi	=	5.4	Binding	Inhibition of 5-HT7 receptor (unknown origin) by PDSP assayInhibition of 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	325	4	1	4	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC	10.1016/j.bmc.2013.07.045
		135398745	2914	112	None	-95	65	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
		47	2914	112	None	-95	65	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
		CHEMBL715	2914	112	None	-95	65	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
		DB00334	2914	112	None	-95	65	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
		162644116	183620	0	None	-4	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	411	10	1	5	3.3	COc1ccccc1CNC(=O)CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4778021	183620	0	None	-4	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	411	10	1	5	3.3	COc1ccccc1CNC(=O)CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4802344	183620	0	None	-4	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	411	10	1	5	3.3	COc1ccccc1CNC(=O)CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.ejmech.2020.112437
		155552054	174011	0	None	-7	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	443	9	0	4	5.2	COc1cccc(N2CCN(CCCCCCN3C(=O)c4cccc5cccc3c45)CC2)c1	10.1016/j.bmcl.2019.06.029
		CHEMBL4542754	174011	0	None	-7	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	443	9	0	4	5.2	COc1cccc(N2CCN(CCCCCCN3C(=O)c4cccc5cccc3c45)CC2)c1	10.1016/j.bmcl.2019.06.029
		155534312	171917	0	None	2	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	445	8	1	4	5.8	O=c1[nH]c(CCCCCN2CCC(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
		CHEMBL4469984	171917	0	None	2	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	445	8	1	4	5.8	O=c1[nH]c(CCCCCN2CCC(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
		135367399	163835	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1ccccc1-c1noc2c1CCNCC2	10.1021/acs.jmedchem.8b00642
		CHEMBL4206411	163835	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1ccccc1-c1noc2c1CCNCC2	10.1021/acs.jmedchem.8b00642
		136116062	97680	0	None	-10	4	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	293	2	2	3	3.5	CC1NC(NCC(F)F)=Nc2c(Cl)ccc(Cl)c21	10.1016/j.bmcl.2007.10.078
		CHEMBL271253	97680	0	None	-10	4	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	293	2	2	3	3.5	CC1NC(NCC(F)F)=Nc2c(Cl)ccc(Cl)c21	10.1016/j.bmcl.2007.10.078
		44391586	166344	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	313	4	0	4	3.2	COc1cccc(OC)c1-c1ccc2c(c1)C[C@H](N(C)C)CO2	10.1016/j.bmcl.2004.11.013
		CHEMBL427326	166344	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	313	4	0	4	3.2	COc1cccc(OC)c1-c1ccc2c(c1)C[C@H](N(C)C)CO2	10.1016/j.bmcl.2004.11.013
		44395817	66799	0	None	1	2	Rat	6.4	pKi	=	6.4	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	441	6	0	5	3.8	COc1ccccc1N1CCN(Cc2ccccc2CN2C(=O)c3ccccc3C2=O)CC1	10.1016/j.bmcl.2004.09.029
		CHEMBL185988	66799	0	None	1	2	Rat	6.4	pKi	=	6.4	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	441	6	0	5	3.8	COc1ccccc1N1CCN(Cc2ccccc2CN2C(=O)c3ccccc3C2=O)CC1	10.1016/j.bmcl.2004.09.029
		44424670	85725	0	None	-14	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	446	6	1	8	1.0	Cn1c(=O)c2c([nH]c(=O)n2CCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2007.05.017
		CHEMBL228940	85725	0	None	-14	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	446	6	1	8	1.0	Cn1c(=O)c2c([nH]c(=O)n2CCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2007.05.017
		135367821	163892	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
		CHEMBL4207073	163892	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
		137636384	155951	0	None	-741	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)	ChEMBL	356	4	0	4	2.5	CN(C)CC1=CC2=CN(S(=O)(=O)c3ccccc3)C3=CC=CC(O1)C23	10.1021/acsmedchemlett.6b00482
		CHEMBL4061189	155951	0	None	-741	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)	ChEMBL	356	4	0	4	2.5	CN(C)CC1=CC2=CN(S(=O)(=O)c3ccccc3)C3=CC=CC(O1)C23	10.1021/acsmedchemlett.6b00482
		11166042	166369	0	None	2	3	Human	7.4	pKi	=	7.4	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	419	9	1	6	2.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.ejmech.2019.111705
		CHEMBL427518	166369	0	None	2	3	Human	7.4	pKi	=	7.4	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	419	9	1	6	2.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.ejmech.2019.111705
		44461069	205595	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	377	5	0	3	4.1	CC(C)CN1CCCN(CCn2ccc3ccc(Br)cc32)CC1	10.1016/s0960-894x(02)00438-9
		CHEMBL81488	205595	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	377	5	0	3	4.1	CC(C)CN1CCCN(CCn2ccc3ccc(Br)cc32)CC1	10.1016/s0960-894x(02)00438-9
		122181338	121880	0	None	-2	3	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	466	6	1	4	4.0	O=C1NC2(CCCc3ccccc32)C(=O)N1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2015.04.026
		CHEMBL3590090	121880	0	None	-2	3	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	466	6	1	4	4.0	O=C1NC2(CCCc3ccccc32)C(=O)N1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2015.04.026
		137650705	157234	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3cccc(Cl)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
		CHEMBL4076408	157234	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3cccc(Cl)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
		137645926	157565	0	None	3	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2017.04.046
		CHEMBL4080398	157565	0	None	3	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2017.04.046
		57395599	68436	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	482	10	0	6	3.9	CCN(CCCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1cccc2cccnc12	10.1016/j.bmc.2011.09.044
		CHEMBL1917357	68436	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	482	10	0	6	3.9	CCN(CCCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1cccc2cccnc12	10.1016/j.bmc.2011.09.044
		156016366	177639	0	None	-4	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	458	10	1	6	4.0	O=S(=O)(NCCCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccccc1	10.1016/j.bmc.2020.115459
		CHEMBL4641296	177639	0	None	-4	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	458	10	1	6	4.0	O=S(=O)(NCCCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccccc1	10.1016/j.bmc.2020.115459
		134130247	154575	0	None	-2	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	308	4	0	3	4.3	c1ccc2c(c1)CCN(CCCc1nc3ccccc3s1)C2	10.1016/j.bmc.2016.09.019
		CHEMBL3890153	154575	0	None	-2	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	308	4	0	3	4.3	c1ccc2c(c1)CCN(CCCc1nc3ccccc3s1)C2	10.1016/j.bmc.2016.09.019
		CHEMBL3991291	154575	0	None	-2	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	308	4	0	3	4.3	c1ccc2c(c1)CCN(CCCc1nc3ccccc3s1)C2	10.1016/j.bmc.2016.09.019
		44374233	51528	2	None	3	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	260	4	0	3	2.5	CN(C)CCSc1cccc(Br)n1	10.1016/j.bmc.2010.01.035
		CHEMBL158285	51528	2	None	3	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	260	4	0	3	2.5	CN(C)CCSc1cccc(Br)n1	10.1016/j.bmc.2010.01.035
		118736373	118945	0	None	-1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	545	7	0	9	3.6	Cn1c(=O)c2c(nc3n(CCCCN4CCN(c5ccc(Cl)cc5)CC4)c(-c4ccccc4)cn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
		CHEMBL3423337	118945	0	None	-1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	545	7	0	9	3.6	Cn1c(=O)c2c(nc3n(CCCCN4CCN(c5ccc(Cl)cc5)CC4)c(-c4ccccc4)cn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
		135398737	958	93	None	-13	89	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/np500893h
		38	958	93	None	-13	89	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/np500893h
		722	958	93	None	-13	89	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/np500893h
		CHEMBL42	958	93	None	-13	89	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/np500893h
		DB00363	958	93	None	-13	89	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/np500893h
		44437334	150498	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	694	18	0	9	5.9	COc1ccccc1N1CCN(CCc2cccc(OCCOCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		CHEMBL395444	150498	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	694	18	0	9	5.9	COc1ccccc1N1CCN(CCc2cccc(OCCOCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		44266178	98366	0	None	6	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	403	4	0	3	3.1	O=C1c2ccccc2CCCN1CCN1CCC(N2C(=O)Cc3ccccc32)CC1	10.1016/s0960-894x(03)00077-5
		CHEMBL275258	98366	0	None	6	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	403	4	0	3	3.1	O=C1c2ccccc2CCCN1CCN1CCC(N2C(=O)Cc3ccccc32)CC1	10.1016/s0960-894x(03)00077-5
		134130247	154575	0	None	-2	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	308	4	0	3	4.3	c1ccc2c(c1)CCN(CCCc1nc3ccccc3s1)C2	10.1016/j.bmc.2016.09.019
		CHEMBL3890153	154575	0	None	-2	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	308	4	0	3	4.3	c1ccc2c(c1)CCN(CCCc1nc3ccccc3s1)C2	10.1016/j.bmc.2016.09.019
		CHEMBL3991291	154575	0	None	-2	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	308	4	0	3	4.3	c1ccc2c(c1)CCN(CCCc1nc3ccccc3s1)C2	10.1016/j.bmc.2016.09.019
		72549986	113823	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	457	10	1	4	5.0	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2014.07.026
		CHEMBL3325464	113823	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	457	10	1	4	5.0	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2014.07.026
		53316914	57028	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	364	4	0	2	5.6	CC(C)N1CCc2c(c(-c3ccc(Cl)cc3)cn2Cc2ccccc2)C1	10.1016/j.bmcl.2010.11.078
		CHEMBL1644490	57028	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	364	4	0	2	5.6	CC(C)N1CCc2c(c(-c3ccc(Cl)cc3)cn2Cc2ccccc2)C1	10.1016/j.bmcl.2010.11.078
		9927441	207394	0	None	-1096	9	Human	5.4	pKi	=	5.4	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	328	5	0	4	3.0	CN(C)CCc1cn(S(=O)(=O)c2ccccc2)c2ccccc12	10.1021/jm010943m
		CHEMBL93868	207394	0	None	-1096	9	Human	5.4	pKi	=	5.4	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	328	5	0	4	3.0	CN(C)CCc1cn(S(=O)(=O)c2ccccc2)c2ccccc12	10.1021/jm010943m
		17055181	162452	1	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	409	7	1	2	6.2	Cc1ccc(COc2ccc(Br)cc2CNC(C)c2ccccc2)cc1	10.1016/j.ejmech.2018.04.010
		CHEMBL4166667	162452	1	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	409	7	1	2	6.2	Cc1ccc(COc2ccc(Br)cc2CNC(C)c2ccccc2)cc1	10.1016/j.ejmech.2018.04.010
		155547436	173572	0	None	-7	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	471	9	0	5	4.8	COc1cccc(N2CCN(CCCCCCN3C(=O)c4cccc5cccc(c45)C3=O)CC2)c1	10.1016/j.bmcl.2019.06.029
		CHEMBL4532741	173572	0	None	-7	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	471	9	0	5	4.8	COc1cccc(N2CCN(CCCCCCN3C(=O)c4cccc5cccc(c45)C3=O)CC2)c1	10.1016/j.bmcl.2019.06.029
		168278783	190730	0	None	-12	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	467	6	0	7	3.9	COc1cc2ncnc(N3CCC(CN4CCN(c5cccc(Cl)c5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
		CHEMBL5182578	190730	0	None	-12	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	467	6	0	7	3.9	COc1cc2ncnc(N3CCC(CN4CCN(c5cccc(Cl)c5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
		135367821	163892	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
		CHEMBL4207073	163892	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
		155521504	176595	0	None	-416	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	432	4	2	6	4.3	COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.ejmech.2019.06.001
		CHEMBL4451939	176595	0	None	-416	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	432	4	2	6	4.3	COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.ejmech.2019.06.001
		CHEMBL4597600	176595	0	None	-416	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	432	4	2	6	4.3	COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.ejmech.2019.06.001
		164618208	185385	0	None	-371	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	467	6	0	5	3.7	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2021.128028
		CHEMBL4860626	185385	0	None	-371	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	467	6	0	5	3.7	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2021.128028
		3132842	162987	9	None	-10	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	411	9	1	4	5.4	CCC1(C)CC(CCNCc2ccc(OC)c(OC)c2)(c2ccc(C)cc2)CCO1	10.1016/j.ejmech.2018.04.010
		CHEMBL4175296	162987	9	None	-10	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	411	9	1	4	5.4	CCC1(C)CC(CCNCc2ccc(OC)c(OC)c2)(c2ccc(C)cc2)CCO1	10.1016/j.ejmech.2018.04.010
		155516282	170069	0	None	-20	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	443	9	0	4	5.2	COc1ccc(N2CCN(CCCCCCN3C(=O)c4cccc5cccc3c45)CC2)cc1	10.1016/j.bmcl.2019.06.029
		CHEMBL4443185	170069	0	None	-20	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	443	9	0	4	5.2	COc1ccc(N2CCN(CCCCCCN3C(=O)c4cccc5cccc3c45)CC2)cc1	10.1016/j.bmcl.2019.06.029
		CHEMBL5281673	194122	0	None	-47	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis	ChEMBL	643	12	0	8	5.8	O=C1CC2Cc3ccsc3C2=NN1CCCCCCCN1CCN(Cc2cccc3c2ccn3S(=O)(=O)c2ccccc2)CC1	10.1016/j.bmc.2023.117256
		122181343	121885	0	None	-17	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	528	7	1	4	5.3	O=C1NC2(CCC(c3ccccc3)CC2)C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2015.04.026
		CHEMBL3590095	121885	0	None	-17	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	528	7	1	4	5.3	O=C1NC2(CCC(c3ccccc3)CC2)C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2015.04.026
		122483292	138111	0	None	-1	7	Human	7.4	pKi	=	7.4	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3764335	138111	0	None	-1	7	Human	7.4	pKi	=	7.4	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765876	138111	0	None	-1	7	Human	7.4	pKi	=	7.4	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		57392108	68433	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	482	10	0	6	3.9	CCN(CCCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1cnc2ccccc2c1	10.1016/j.bmc.2011.09.044
		CHEMBL1917354	68433	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	482	10	0	6	3.9	CCN(CCCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1cnc2ccccc2c1	10.1016/j.bmc.2011.09.044
		145971561	164509	0	None	7	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	444	4	1	4	3.7	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccc(Cl)c(Cl)c3)CC1)C2	10.1016/j.bmcl.2018.06.019
		CHEMBL4214709	164509	0	None	7	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	444	4	1	4	3.7	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccc(Cl)c(Cl)c3)CC1)C2	10.1016/j.bmcl.2018.06.019
		122483292	138111	0	None	-1	7	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3764335	138111	0	None	-1	7	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765876	138111	0	None	-1	7	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		56945046	112060	0	None	-6	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	500	7	1	6	4.6	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
		CHEMBL3289955	112060	0	None	-6	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	500	7	1	6	4.6	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
		122178706	121372	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	425	8	0	5	5.4	CCCCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
		CHEMBL3581251	121372	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	425	8	0	5	5.4	CCCCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
		42618264	181479	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	394	8	1	5	3.3	COc1ccccc1N1CCN(CCCCCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
		CHEMBL476464	181479	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	394	8	1	5	3.3	COc1ccccc1N1CCN(CCCCCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
		CHEMBL5090557	215270	0	None	-54	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		C[C@H]1C[C@H](NS(=O)(=O)c2cc3ccccc3s2)CN1CCCc1noc2cc(F)ccc12	10.1021/acs.jmedchem.1c00497
		162665588	182396	0	None	-85	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	438	7	1	6	3.3	Cn1ccc2cc(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)ccc21	10.1016/j.ejmech.2020.112149
		CHEMBL4785434	182396	0	None	-85	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	438	7	1	6	3.3	Cn1ccc2cc(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)ccc21	10.1016/j.ejmech.2020.112149
		122483292	138111	0	None	-1	7	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3764335	138111	0	None	-1	7	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765876	138111	0	None	-1	7	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		10610641	98919	0	None	-2	5	Rat	7.4	pKi	=	7.4	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	249	0	0	1	3.7	Cc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm9911433
		CHEMBL27940	98919	0	None	-2	5	Rat	7.4	pKi	=	7.4	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	249	0	0	1	3.7	Cc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm9911433
		11466615	138051	0	None	2	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	451	9	1	5	4.2	COc1ccc2c(c1)C(NC(=O)CCCCN1CCN(c3ccccc3OC)CC1)CCC2	10.1021/jm049702f
		CHEMBL376531	138051	0	None	2	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	451	9	1	5	4.2	COc1ccc2c(c1)C(NC(=O)CCCCN1CCN(c3ccccc3OC)CC1)CCC2	10.1021/jm049702f
		135458428	155534	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	255	3	2	4	2.2	COc1cccc2c1N=C(NCC(F)F)NC2C	10.1016/j.bmcl.2007.10.078
		CHEMBL404248	155534	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	255	3	2	4	2.2	COc1cccc2c1N=C(NCC(F)F)NC2C	10.1016/j.bmcl.2007.10.078
		66801701	159329	0	None	-6	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	471	8	2	3	5.3	Cc1cccc(S(=O)(=O)NCCCCN2CC=C(c3c(C)[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
		CHEMBL4099997	159329	0	None	-6	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	471	8	2	3	5.3	Cc1cccc(S(=O)(=O)NCCCCN2CC=C(c3c(C)[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
		155521010	170592	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	572	9	1	6	5.4	COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
		CHEMBL4450652	170592	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	572	9	1	6	5.4	COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
		90644075	112079	0	None	-6	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	484	8	1	7	3.2	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
		CHEMBL3289973	112079	0	None	-6	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	484	8	1	7	3.2	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
		46206026	124606	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	289	2	1	1	4.5	Cc1cc(-c2ccc(Cl)cc2C2CCNC2)ccc1F	nan
		CHEMBL3640611	124606	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	289	2	1	1	4.5	Cc1cc(-c2ccc(Cl)cc2C2CCNC2)ccc1F	nan
		46206026	124606	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	289	2	1	1	4.5	Cc1cc(-c2ccc(Cl)cc2C2CCNC2)ccc1F	nan
		CHEMBL3640611	124606	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	289	2	1	1	4.5	Cc1cc(-c2ccc(Cl)cc2C2CCNC2)ccc1F	nan
		2927683	162202	9	None	-2	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	353	8	1	2	6.0	CC(NCCC(Cc1ccccc1)c1ccco1)c1ccc(Cl)cc1	10.1016/j.ejmech.2018.04.010
		CHEMBL4162688	162202	9	None	-2	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	353	8	1	2	6.0	CC(NCCC(Cc1ccccc1)c1ccco1)c1ccc(Cl)cc1	10.1016/j.ejmech.2018.04.010
		146025727	171685	0	None	-141	27	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4466483	171685	0	None	-141	27	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		155536152	172139	0	None	-29	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	368	4	1	7	2.1	CN1CCN(c2nc(N)nc(COc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.ejmech.2019.06.022
		CHEMBL4473083	172139	0	None	-29	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	368	4	1	7	2.1	CN1CCN(c2nc(N)nc(COc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.ejmech.2019.06.022
		57396855	71474	0	None	2	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc2cccnc2c1	10.1016/j.bmc.2011.12.039
		CHEMBL1949969	71474	0	None	2	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc2cccnc2c1	10.1016/j.bmc.2011.12.039
		CHEMBL1962400	71474	0	None	2	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc2cccnc2c1	10.1016/j.bmc.2011.12.039
		118736375	118947	0	None	-14	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	477	6	0	9	2.2	Cc1cccc(N2CCN(CCCCn3c(C)cn4c5c(=O)n(C)c(=O)n(C)c5nc34)CC2)c1C	10.1016/j.ejmech.2015.04.046
		CHEMBL3423339	118947	0	None	-14	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	477	6	0	9	2.2	Cc1cccc(N2CCN(CCCCn3c(C)cn4c5c(=O)n(C)c(=O)n(C)c5nc34)CC2)c1C	10.1016/j.ejmech.2015.04.046
		71461050	82977	0	None	-123	4	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	352	5	0	3	5.0	CCCN1CCC(COc2nc3c(F)cccc3c3ccccc23)CC1	10.1021/jm300943r
		CHEMBL2181189	82977	0	None	-123	4	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	352	5	0	3	5.0	CCCN1CCC(COc2nc3c(F)cccc3c3ccccc23)CC1	10.1021/jm300943r
		10971846	50493	0	None	-1	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	420	8	1	4	5.0	O=C(CCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)c1ccccc1O	10.1021/jm020994z
		CHEMBL157362	50493	0	None	-1	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	420	8	1	4	5.0	O=C(CCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)c1ccccc1O	10.1021/jm020994z
		139488518	169997	0	None	14	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	229	2	1	2	3.2	CCn1cncc1-c1c[nH]c2cccc(F)c12	10.1016/j.ejmech.2019.03.017
		CHEMBL4442337	169997	0	None	14	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	229	2	1	2	3.2	CCn1cncc1-c1c[nH]c2cccc(F)c12	10.1016/j.ejmech.2019.03.017
		135367936	164473	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
		CHEMBL4214171	164473	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
		156017609	177901	0	None	-19	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	464	9	1	6	4.9	O=C1CCc2cc(OCCCCCCN3CCN(c4nsc5ccccc45)CC3)ccc2N1	10.1016/j.bmc.2020.115459
		CHEMBL4644906	177901	0	None	-19	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	464	9	1	6	4.9	O=C1CCc2cc(OCCCCCCN3CCN(c4nsc5ccccc45)CC3)ccc2N1	10.1016/j.bmc.2020.115459
		155519102	170355	0	None	-371	5	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	348	4	1	7	2.0	CC(Oc1ccccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
		CHEMBL4447416	170355	0	None	-371	5	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	348	4	1	7	2.0	CC(Oc1ccccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
		155519102	170355	0	None	-371	5	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	348	4	1	7	2.0	CC(Oc1ccccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
		CHEMBL4447416	170355	0	None	-371	5	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	348	4	1	7	2.0	CC(Oc1ccccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
		155519102	170355	0	None	-371	5	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	348	4	1	7	2.0	CC(Oc1ccccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2022.114645
		CHEMBL4447416	170355	0	None	-371	5	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	348	4	1	7	2.0	CC(Oc1ccccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2022.114645
		1220	187	55	None	-208	44	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmcl.2016.06.080
		31	187	55	None	-208	44	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmcl.2016.06.080
		7	187	55	None	-208	44	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmcl.2016.06.080
		CHEMBL56	187	55	None	-208	44	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmcl.2016.06.080
		1220	187	55	None	-208	44	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmc.2016.12.039
		31	187	55	None	-208	44	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmc.2016.12.039
		7	187	55	None	-208	44	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmc.2016.12.039
		CHEMBL56	187	55	None	-208	44	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmc.2016.12.039
		1220	187	55	None	-208	44	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmcl.2015.02.042
		31	187	55	None	-208	44	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmcl.2015.02.042
		7	187	55	None	-208	44	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmcl.2015.02.042
		CHEMBL56	187	55	None	-208	44	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmcl.2015.02.042
		145946527	167570	0	None	-10	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	382	10	0	4	3.6	Cc1cccc(OCCOCCN2CCN(CCc3ccccc3)CC2)c1C	10.1016/j.bmcl.2018.04.059
		CHEMBL4217761	167570	0	None	-10	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	382	10	0	4	3.6	Cc1cccc(OCCOCCN2CCN(CCc3ccccc3)CC2)c1C	10.1016/j.bmcl.2018.04.059
		CHEMBL4300609	167570	0	None	-10	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	382	10	0	4	3.6	Cc1cccc(OCCOCCN2CCN(CCc3ccccc3)CC2)c1C	10.1016/j.bmcl.2018.04.059
		134155651	151130	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	329	4	0	2	5.2	COc1ccccc1-c1cc(CN2CCC(C)CC2)ccc1Cl	10.1016/j.ejmech.2016.07.029
		CHEMBL3959382	151130	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	329	4	0	2	5.2	COc1ccccc1-c1cc(CN2CCC(C)CC2)ccc1Cl	10.1016/j.ejmech.2016.07.029
		25107652	187412	0	None	-20	3	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	396	10	1	5	3.1	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	10.1021/jm800615e
		CHEMBL493709	187412	0	None	-20	3	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	396	10	1	5	3.1	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	10.1021/jm800615e
		142601325	185869	0	None	3	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	242	2	2	3	1.9	c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4868035	185869	0	None	3	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	242	2	2	3	1.9	c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		135367936	164473	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
		CHEMBL4214171	164473	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
		137655411	158756	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	5.2	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1016/j.bmc.2017.04.046
		CHEMBL4093971	158756	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	5.2	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1016/j.bmc.2017.04.046
		127026147	137739	0	None	12	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	417	8	2	5	3.2	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(N)cc2)CC1	10.1016/j.ejmech.2015.11.040
		CHEMBL3759161	137739	0	None	12	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	417	8	2	5	3.2	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(N)cc2)CC1	10.1016/j.ejmech.2015.11.040
		156014041	177208	0	None	-2	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	443	8	0	4	4.1	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2020.115459
		CHEMBL4635363	177208	0	None	-2	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	443	8	0	4	4.1	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2020.115459
		90656700	112684	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	417	9	1	4	5.4	CN(CCCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3259846	112684	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	417	9	1	4	5.4	CN(CCCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3304188	112684	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	417	9	1	4	5.4	CN(CCCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		90656687	110984	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	402	8	1	5	2.7	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(NS(C)(=O)=O)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262417	110984	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	402	8	1	5	2.7	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(NS(C)(=O)=O)c1	10.1016/j.ejmech.2014.04.034
		145	140	49	None	-4	30	Rat	7.4	pKi	=	7.4	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm030826m
		1832	140	49	None	-4	30	Rat	7.4	pKi	=	7.4	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm030826m
		CHEMBL7257	140	49	None	-4	30	Rat	7.4	pKi	=	7.4	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm030826m
		DB14010	140	49	None	-4	30	Rat	7.4	pKi	=	7.4	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm030826m
		49850570	56472	0	None	-251	9	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	417	6	2	4	4.0	CCNC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
		CHEMBL1632220	56472	0	None	-251	9	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	417	6	2	4	4.0	CCNC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
		44343212	9838	0	None	50	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor 7(a) (human cloned receptor in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor 7(a) (human cloned receptor in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	400	5	0	3	4.5	CC1CCN(CCC2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
		CHEMBL114012	9838	0	None	50	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor 7(a) (human cloned receptor in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor 7(a) (human cloned receptor in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	400	5	0	3	4.5	CC1CCN(CCC2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
		135398737	958	93	None	-13	89	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2010.03.012
		38	958	93	None	-13	89	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2010.03.012
		722	958	93	None	-13	89	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2010.03.012
		CHEMBL42	958	93	None	-13	89	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2010.03.012
		DB00363	958	93	None	-13	89	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2010.03.012
		9934284	90296	0	None	-100	10	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	467	6	1	5	4.5	Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cc(F)cc2n1	10.1016/j.bmcl.2006.11.031
		CHEMBL238520	90296	0	None	-100	10	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	467	6	1	5	4.5	Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cc(F)cc2n1	10.1016/j.bmcl.2006.11.031
		44439165	145753	0	None	-15	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
		CHEMBL391661	145753	0	None	-15	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
		11475386	122632	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	410	7	1	4	3.6	COc1ccc2c(c1)CCN(CCCNS(=O)(=O)c1cccc3ccccc13)C2	10.1021/jm049743b
		CHEMBL360382	122632	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	410	7	1	4	3.6	COc1ccc2c(c1)CCN(CCCNS(=O)(=O)c1cccc3ccccc13)C2	10.1021/jm049743b
		156022135	178218	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	341	6	0	1	6.0	CCCN(CCC)[C@@H]1CCc2c(cccc2-c2ccccc2Cl)C1	10.1016/j.bmc.2019.115262
		CHEMBL4649788	178218	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	341	6	0	1	6.0	CCCN(CCC)[C@@H]1CCc2c(cccc2-c2ccccc2Cl)C1	10.1016/j.bmc.2019.115262
		4223	3992	94	None	-81	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1016/j.bmcl.2019.126703
		6918314	3992	94	None	-81	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1016/j.bmcl.2019.126703
		7427	3992	94	None	-81	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1016/j.bmcl.2019.126703
		CHEMBL439849	3992	94	None	-81	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1016/j.bmcl.2019.126703
		DB06684	3992	94	None	-81	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1016/j.bmcl.2019.126703
		76332583	106415	0	None	-1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	319	3	0	3	3.7	Cc1ccccc1-n1cc(CN2CCN(C)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
		CHEMBL3121439	106415	0	None	-1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	319	3	0	3	3.7	Cc1ccccc1-n1cc(CN2CCN(C)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
		CHEMBL3139517	106415	0	None	-1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	319	3	0	3	3.7	Cc1ccccc1-n1cc(CN2CCN(C)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
		71453157	81172	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	418	7	1	3	4.8	O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc(F)c1	10.1016/j.ejmech.2012.07.043
		CHEMBL2158038	81172	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	418	7	1	3	4.8	O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc(F)c1	10.1016/j.ejmech.2012.07.043
		162676059	183786	0	None	-2	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	9	1	4	4.6	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4796573	183786	0	None	-2	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	9	1	4	4.6	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4804095	183786	0	None	-2	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	9	1	4	4.6	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
		142601325	185869	0	None	3	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	242	2	2	3	1.9	c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4868035	185869	0	None	3	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	242	2	2	3	1.9	c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		90654679	110100	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	468	8	1	4	3.5	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235751	110100	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	468	8	1	4	3.5	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.ejmech.2014.03.005
		156017397	177697	0	None	-1	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	420	7	1	4	5.0	CCCC(=O)Nc1ccc2c(c1)-c1c(OCC3CC3)c(OC)cc3c1C(C2)N(C)CC3	10.1016/j.bmc.2020.115578
		CHEMBL4642034	177697	0	None	-1	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	420	7	1	4	5.0	CCCC(=O)Nc1ccc2c(c1)-c1c(OCC3CC3)c(OC)cc3c1C(C2)N(C)CC3	10.1016/j.bmc.2020.115578
		16117151	60087	0	None	-3981	7	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	390	4	3	5	3.2	O=S(=O)(c1cccc(Cl)c1)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
		CHEMBL1642882	60087	0	None	-3981	7	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	390	4	3	5	3.2	O=S(=O)(c1cccc(Cl)c1)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
		CHEMBL1739102	60087	0	None	-3981	7	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	390	4	3	5	3.2	O=S(=O)(c1cccc(Cl)c1)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
		127026052	137553	0	None	-23	19	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay	ChEMBL	258	7	1	1	3.5	C=CCN(CC=C)CCc1c[nH]c2ccc(F)cc12	10.1016/j.bmcl.2015.12.053
		CHEMBL3754496	137553	0	None	-23	19	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay	ChEMBL	258	7	1	1	3.5	C=CCN(CC=C)CCc1c[nH]c2ccc(F)cc12	10.1016/j.bmcl.2015.12.053
		10715998	45228	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	400	5	0	3	4.5	CC1CCN(CC[C@@H]2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
		CHEMBL152595	45228	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	400	5	0	3	4.5	CC1CCN(CC[C@@H]2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
		10596321	207464	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
		CHEMBL94261	207464	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
		11281062	119657	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	401	6	0	4	4.0	COc1ccccc1N1CCN(CCCN2C(=O)c3cccc4cccc2c34)CC1	10.1021/jm030841r
		CHEMBL346906	119657	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	401	6	0	4	4.0	COc1ccccc1N1CCN(CCCN2C(=O)c3cccc4cccc2c34)CC1	10.1021/jm030841r
		147653864	171561	0	None	-19	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	267	0	1	2	2.7	C[C@@]12COc3c(Br)cccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
		CHEMBL4464697	171561	0	None	-19	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	267	0	1	2	2.7	C[C@@]12COc3c(Br)cccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
		11168182	3534	25	None	-630	13	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT	ChEMBL	511	14	1	3	6.5	CN(CCN(C(=O)CCC1CCCC1)Cc1ccc(cc1)c1ccc(cc1)CNCCc1ccccc1)C	10.1016/j.bmcl.2005.06.024
		264	3534	25	None	-630	13	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT	ChEMBL	511	14	1	3	6.5	CN(CCN(C(=O)CCC1CCCC1)Cc1ccc(cc1)c1ccc(cc1)CNCCc1ccccc1)C	10.1016/j.bmcl.2005.06.024
		CHEMBL1181770	3534	25	None	-630	13	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT	ChEMBL	511	14	1	3	6.5	CN(CCN(C(=O)CCC1CCCC1)Cc1ccc(cc1)c1ccc(cc1)CNCCc1ccccc1)C	10.1016/j.bmcl.2005.06.024
		276	3513	50	None	-100	13	Human	5.4	pKi	=	5.4	Binding	Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1021/jm980532e
		5312149	3513	50	None	-100	13	Human	5.4	pKi	=	5.4	Binding	Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1021/jm980532e
		CHEMBL431298	3513	50	None	-100	13	Human	5.4	pKi	=	5.4	Binding	Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1021/jm980532e
		276	3513	50	None	-100	13	Human	5.4	pKi	=	5.4	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/s0960-894x(02)00172-5
		5312149	3513	50	None	-100	13	Human	5.4	pKi	=	5.4	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/s0960-894x(02)00172-5
		CHEMBL431298	3513	50	None	-100	13	Human	5.4	pKi	=	5.4	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/s0960-894x(02)00172-5
		44393007	66293	0	None	120	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	351	8	2	4	4.9	C[C@H](Nc1cncc(NCCOc2ccc(F)cc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		CHEMBL184789	66293	0	None	120	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	351	8	2	4	4.9	C[C@H](Nc1cncc(NCCOc2ccc(F)cc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		44393229	66697	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	335	7	2	3	5.0	C[C@H](Nc1cc(NCCc2ccc(F)cc2)ccn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		CHEMBL185512	66697	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	335	7	2	3	5.0	C[C@H](Nc1cc(NCCc2ccc(F)cc2)ccn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		44393004	122174	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	333	8	2	4	4.7	C[C@H](Nc1cncc(NCCOc2ccccc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		CHEMBL359725	122174	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	333	8	2	4	4.7	C[C@H](Nc1cncc(NCCOc2ccccc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		5	139	72	None	-3	54	Human	8.4	pKi	=	8.4	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
		5202	139	72	None	-3	54	Human	8.4	pKi	=	8.4	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
		CHEMBL39	139	72	None	-3	54	Human	8.4	pKi	=	8.4	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
		DB08839	139	72	None	-3	54	Human	8.4	pKi	=	8.4	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
		145965054	164289	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	472	7	2	4	3.8	CNC(=O)CN1c2ccccc2C2CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC21	10.1021/acs.jmedchem.7b01898
		CHEMBL4211987	164289	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	472	7	2	4	3.8	CNC(=O)CN1c2ccccc2C2CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC21	10.1021/acs.jmedchem.7b01898
		9956365	195518	0	None	34	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	470	7	2	4	4.1	CNC(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm030030n
		CHEMBL553794	195518	0	None	34	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	470	7	2	4	4.1	CNC(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm030030n
		76320705	103539	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	352	1	0	2	5.2	CC1C=CC=C(C#N)[C@@H]1c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm049743b
		CHEMBL3085301	103539	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	352	1	0	2	5.2	CC1C=CC=C(C#N)[C@@H]1c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm049743b
		4106	2502	22	None	-2	34	Rat	8.4	pKi	=	8.4	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm030030n
		5358812	2502	22	None	-2	34	Rat	8.4	pKi	=	8.4	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm030030n
		89	2502	22	None	-2	34	Rat	8.4	pKi	=	8.4	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm030030n
		CHEMBL93240	2502	22	None	-2	34	Rat	8.4	pKi	=	8.4	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm030030n
		127024951	137640	0	None	51	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	8	1	4	4.8	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2cccc(Cl)c2)C3)c1	10.1016/j.ejmech.2015.11.040
		CHEMBL3758286	137640	0	None	51	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	8	1	4	4.8	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2cccc(Cl)c2)C3)c1	10.1016/j.ejmech.2015.11.040
		127026131	137750	0	None	12	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	464	8	1	4	4.4	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2cc(F)ccc2F)C3)c1	10.1016/j.ejmech.2015.11.040
		CHEMBL3759233	137750	0	None	12	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	464	8	1	4	4.4	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2cc(F)ccc2F)C3)c1	10.1016/j.ejmech.2015.11.040
		118626101	165724	0	None	-1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	489	6	1	5	4.1	O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3[nH]ccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4245997	165724	0	None	-1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	489	6	1	5	4.1	O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3[nH]ccc23)CC1	10.1016/j.ejmech.2018.01.002
		118626142	165820	0	None	1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4248491	165820	0	None	1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
		71453281	81442	0	None	6	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	422	8	1	4	3.9	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(Cl)c2)C1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159485	81442	0	None	6	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	422	8	1	4	3.9	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(Cl)c2)C1	10.1016/j.ejmech.2012.07.043
		71451460	81445	0	None	9	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	8	1	5	4.5	O=S(=O)(N[C@@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159488	81445	0	None	9	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	8	1	5	4.5	O=S(=O)(N[C@@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
		139488606	170757	1	None	147	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	355	2	1	2	3.8	CCn1cncc1-c1c[nH]c2ccc(I)c(F)c12	10.1016/j.ejmech.2019.03.017
		CHEMBL4452569	170757	1	None	147	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	355	2	1	2	3.8	CCn1cncc1-c1c[nH]c2ccc(I)c(F)c12	10.1016/j.ejmech.2019.03.017
		54758295	66000	0	None	13	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	378	7	1	4	3.7	CCC1(CCCCN2CCN(c3ccccn3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
		CHEMBL1836789	66000	0	None	13	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	378	7	1	4	3.7	CCC1(CCCCN2CCN(c3ccccn3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
		118706732	120527	0	None	-3	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	295	1	3	2	1.6	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
		CHEMBL3310713	120527	0	None	-3	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	295	1	3	2	1.6	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
		CHEMBL3545445	120527	0	None	-3	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	295	1	3	2	1.6	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
		44374233	51528	2	None	3	5	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	260	4	0	3	2.5	CN(C)CCSc1cccc(Br)n1	10.1016/j.bmcl.2003.11.050
		CHEMBL158285	51528	2	None	3	5	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	260	4	0	3	2.5	CN(C)CCSc1cccc(Br)n1	10.1016/j.bmcl.2003.11.050
		44374233	51528	2	None	3	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5CT from 5HT7B receptorDisplacement of [3H]5CT from 5HT7B receptor	ChEMBL	260	4	0	3	2.5	CN(C)CCSc1cccc(Br)n1	10.1016/j.bmc.2010.01.035
		CHEMBL158285	51528	2	None	3	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5CT from 5HT7B receptorDisplacement of [3H]5CT from 5HT7B receptor	ChEMBL	260	4	0	3	2.5	CN(C)CCSc1cccc(Br)n1	10.1016/j.bmc.2010.01.035
		118706285	112888	0	None	-2	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	295	2	3	2	1.7	CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
		CHEMBL3310113	112888	0	None	-2	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	295	2	3	2	1.7	CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
		118706301	120538	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	265	1	2	1	2.2	CC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
		CHEMBL3310122	120538	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	265	1	2	1	2.2	CC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
		CHEMBL3545473	120538	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	265	1	2	1	2.2	CC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
		66801455	112069	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	470	8	1	8	2.8	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cnc2ccccn12	10.1021/jm401895u
		CHEMBL3289964	112069	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	470	8	1	8	2.8	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cnc2ccccn12	10.1021/jm401895u
		66801062	112118	0	None	-4	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	473	7	1	6	4.7	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
		CHEMBL3290011	112118	0	None	-4	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	473	7	1	6	4.7	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
		11282296	143315	0	None	-1	4	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	447	9	1	4	4.8	CC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
		CHEMBL389718	143315	0	None	-1	4	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	447	9	1	4	4.8	CC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
		135458427	171553	0	None	5	5	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	283	4	2	4	3.0	CC(C)Oc1cccc2c1N=C(NCC(F)F)NC2C	10.1016/j.bmcl.2007.10.078
		CHEMBL446459	171553	0	None	5	5	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	283	4	2	4	3.0	CC(C)Oc1cccc2c1N=C(NCC(F)F)NC2C	10.1016/j.bmcl.2007.10.078
		118524962	177669	0	None	3	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	285	2	0	1	4.4	CN(C)C1CCc2c(cccc2-c2ccccc2Cl)C1	10.1016/j.bmc.2019.115262
		CHEMBL4641654	177669	0	None	3	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	285	2	0	1	4.4	CN(C)C1CCc2c(cccc2-c2ccccc2Cl)C1	10.1016/j.bmc.2019.115262
		11694810	120539	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
		CHEMBL3310123	120539	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
		CHEMBL3545474	120539	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
		10707685	162953	0	None	6	4	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	277	0	1	2	3.0	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@]3(C)O	10.1021/jm9911433
		CHEMBL417473	162953	0	None	6	4	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	277	0	1	2	3.0	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@]3(C)O	10.1021/jm9911433
		11694810	120539	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
		CHEMBL3310123	120539	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
		CHEMBL3545474	120539	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
		66801225	112117	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	487	8	1	6	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1csc2ccccc12	10.1021/jm401895u
		CHEMBL3290010	112117	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	487	8	1	6	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1csc2ccccc12	10.1021/jm401895u
		2389	3331	118	None	-8	67	Human	8.4	pKi	=	8.4	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
		5073	3331	118	None	-8	67	Human	8.4	pKi	=	8.4	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
		96	3331	118	None	-8	67	Human	8.4	pKi	=	8.4	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
		CHEMBL85	3331	118	None	-8	67	Human	8.4	pKi	=	8.4	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
		DB00734	3331	118	None	-8	67	Human	8.4	pKi	=	8.4	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
		44388858	61497	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	361	5	0	4	4.1	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1	10.1016/j.bmcl.2009.02.008
		CHEMBL177064	61497	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	361	5	0	4	4.1	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1	10.1016/j.bmcl.2009.02.008
		11566558	159456	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	354	6	1	3	4.6	CCC1(CCCCN2CCc3sccc3C2)C(=O)Nc2ccccc21	10.1021/jm070279v
		CHEMBL410128	159456	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	354	6	1	3	4.6	CCC1(CCCCN2CCc3sccc3C2)C(=O)Nc2ccccc21	10.1021/jm070279v
		109018769	175288	1	None	-12	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	337	7	1	3	2.5	O=C(CCN1CCN(Cc2ccccc2)CC1)NCc1ccccc1	10.1016/j.bmcl.2016.06.080
		CHEMBL4572955	175288	1	None	-12	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	337	7	1	3	2.5	O=C(CCN1CCN(Cc2ccccc2)CC1)NCc1ccccc1	10.1016/j.bmcl.2016.06.080
		56944191	112102	0	None	2	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	483	8	1	5	4.7	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
		CHEMBL3289996	112102	0	None	2	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	483	8	1	5	4.7	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
		46206347	124559	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	289	4	1	3	3.4	COc1ccc(-c2ccccc2Cl)cc1OC1CNC1	nan
		CHEMBL3640566	124559	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	289	4	1	3	3.4	COc1ccc(-c2ccccc2Cl)cc1OC1CNC1	nan
		46206347	124559	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	289	4	1	3	3.4	COc1ccc(-c2ccccc2Cl)cc1OC1CNC1	nan
		CHEMBL3640566	124559	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	289	4	1	3	3.4	COc1ccc(-c2ccccc2Cl)cc1OC1CNC1	nan
		22449331	106935	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	360	5	1	2	4.4	O=C1Nc2cccc3c2C1(CCCCN1CCc2ccccc2C1)CCC3	10.1016/s0960-894x(02)00485-7
		CHEMBL314830	106935	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	360	5	1	2	4.4	O=C1Nc2cccc3c2C1(CCCCN1CCc2ccccc2C1)CCC3	10.1016/s0960-894x(02)00485-7
		44266156	98403	0	None	7	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	382	5	0	3	3.8	O=C1c2ccccc2CCCN1CCN1CCC(Oc2ccc(F)cc2)CC1	10.1016/s0960-894x(03)00077-5
		CHEMBL275451	98403	0	None	7	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	382	5	0	3	3.8	O=C1c2ccccc2CCCN1CCN1CCC(Oc2ccc(F)cc2)CC1	10.1016/s0960-894x(03)00077-5
		11662592	72344	0	None	-3	9	Human	8.4	pKi	=	8.4	Binding	Inhibitory activity against 5HT7 receptorInhibitory activity against 5HT7 receptor	ChEMBL	460	4	0	8	2.8	CN1CCc2c(sc3ncn(CCN4CCN(c5ccnc6ccccc56)CC4)c(=O)c23)C1	10.1016/j.bmcl.2005.04.077
		CHEMBL198463	72344	0	None	-3	9	Human	8.4	pKi	=	8.4	Binding	Inhibitory activity against 5HT7 receptorInhibitory activity against 5HT7 receptor	ChEMBL	460	4	0	8	2.8	CN1CCc2c(sc3ncn(CCN4CCN(c5ccnc6ccccc56)CC4)c(=O)c23)C1	10.1016/j.bmcl.2005.04.077
		76321735	106396	0	None	15	3	Human	8.4	pKi	=	8.4	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	447	5	0	4	6.1	COc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1	10.1016/j.ejmech.2019.111705
		CHEMBL3121424	106396	0	None	15	3	Human	8.4	pKi	=	8.4	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	447	5	0	4	6.1	COc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1	10.1016/j.ejmech.2019.111705
		CHEMBL3139441	106396	0	None	15	3	Human	8.4	pKi	=	8.4	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	447	5	0	4	6.1	COc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1	10.1016/j.ejmech.2019.111705
		76321735	106396	0	None	15	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	447	5	0	4	6.1	COc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
		CHEMBL3121424	106396	0	None	15	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	447	5	0	4	6.1	COc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
		CHEMBL3139441	106396	0	None	15	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	447	5	0	4	6.1	COc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
		134156520	154115	0	None	8	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	501	13	1	5	5.3	COCOc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		CHEMBL3985152	154115	0	None	8	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	501	13	1	5	5.3	COCOc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		156013673	177261	0	None	10	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	293	1	2	2	2.9	CN1CCc2cccc3c2C1Cc1ccc(NC(N)=O)cc1-3	10.1016/j.bmc.2020.115578
		CHEMBL4636148	177261	0	None	10	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	293	1	2	2	2.9	CN1CCc2cccc3c2C1Cc1ccc(NC(N)=O)cc1-3	10.1016/j.bmc.2020.115578
		66800916	112067	0	None	1	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	518	8	1	7	4.8	Cc1c(S(=O)(=O)NCCCCN2CCN(c3nsc4ccccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
		CHEMBL3289962	112067	0	None	1	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	518	8	1	7	4.8	Cc1c(S(=O)(=O)NCCCCN2CCN(c3nsc4ccccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
		44388858	61497	0	None	1	4	Human	8.3	pKi	=	8.3	Binding	Binding affinity against Human 5-HT7R expressed in sf9 cellsBinding affinity against Human 5-HT7R expressed in sf9 cells	ChEMBL	361	5	0	4	4.1	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1	10.1016/j.bmcl.2005.05.059
		CHEMBL177064	61497	0	None	1	4	Human	8.3	pKi	=	8.3	Binding	Binding affinity against Human 5-HT7R expressed in sf9 cellsBinding affinity against Human 5-HT7R expressed in sf9 cells	ChEMBL	361	5	0	4	4.1	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1	10.1016/j.bmcl.2005.05.059
		44388858	61497	0	None	1	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	361	5	0	4	4.1	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1	10.1016/j.bmcl.2007.03.054
		CHEMBL177064	61497	0	None	1	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	361	5	0	4	4.1	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1	10.1016/j.bmcl.2007.03.054
		24854043	95901	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2c(Cl)cc(F)cc21	10.1021/jm070279v
		CHEMBL259215	95901	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2c(Cl)cc(F)cc21	10.1021/jm070279v
		10971401	102696	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	400	6	1	2	5.5	Cc1ccc(C2=CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC2)cc1	10.1021/jm0104264
		CHEMBL304731	102696	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	400	6	1	2	5.5	Cc1ccc(C2=CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC2)cc1	10.1021/jm0104264
		164609172	184407	0	None	10	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	378	6	1	5	2.8	O=C1CCc2cc(C(=O)CCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
		CHEMBL4845947	184407	0	None	10	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	378	6	1	5	2.8	O=C1CCc2cc(C(=O)CCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
		162674129	183213	0	None	-10	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	441	7	1	6	4.0	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2s1	10.1016/j.ejmech.2020.112149
		CHEMBL4795995	183213	0	None	-10	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	441	7	1	6	4.0	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2s1	10.1016/j.ejmech.2020.112149
		164609172	184407	0	None	10	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	378	6	1	5	2.8	O=C1CCc2cc(C(=O)CCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
		CHEMBL4845947	184407	0	None	10	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	378	6	1	5	2.8	O=C1CCc2cc(C(=O)CCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
		44437331	90963	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	734	21	0	8	8.2	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		CHEMBL239530	90963	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	734	21	0	8	8.2	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		135339817	181484	0	None	1	7	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	437	6	0	5	4.2	CN1CCc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2C1=O	10.1016/j.ejmech.2020.112709
		CHEMBL4764679	181484	0	None	1	7	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	437	6	0	5	4.2	CN1CCc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2C1=O	10.1016/j.ejmech.2020.112709
		11687730	120585	0	None	-9	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	277	1	2	1	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		CHEMBL3343668	120585	0	None	-9	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	277	1	2	1	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		CHEMBL3545816	120585	0	None	-9	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	277	1	2	1	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		127024950	137791	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	412	8	1	6	2.1	Cn1cc(S(=O)(=O)NC2CN(CCOc3ccccc3-c3ccccc3)C2)cn1	10.1016/j.ejmech.2015.11.040
		CHEMBL3759558	137791	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	412	8	1	6	2.1	Cn1cc(S(=O)(=O)NC2CN(CCOc3ccccc3-c3ccccc3)C2)cn1	10.1016/j.ejmech.2015.11.040
		118731360	118196	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	544	9	0	4	5.5	CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(=O)N2CCCCC2)CC1	10.1016/j.ejmech.2014.12.041
		CHEMBL3409043	118196	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	544	9	0	4	5.5	CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(=O)N2CCCCC2)CC1	10.1016/j.ejmech.2014.12.041
		162668650	182673	0	None	-13	4	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	284	3	2	4	2.9	CNc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
		CHEMBL4789085	182673	0	None	-13	4	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	284	3	2	4	2.9	CNc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
		57396419	71542	0	None	1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cnc2ccccc2c1)N1CCC(CCN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
		CHEMBL1949976	71542	0	None	1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cnc2ccccc2c1)N1CCC(CCN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
		CHEMBL1962961	71542	0	None	1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cnc2ccccc2c1)N1CCC(CCN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
		82187974	112681	1	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	296	5	1	3	3.1	Oc1cccc(CCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262406	112681	1	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	296	5	1	3	3.1	Oc1cccc(CCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3304139	112681	1	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	296	5	1	3	3.1	Oc1cccc(CCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
		135398737	958	93	None	-13	89	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030030n
		38	958	93	None	-13	89	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030030n
		722	958	93	None	-13	89	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030030n
		CHEMBL42	958	93	None	-13	89	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030030n
		DB00363	958	93	None	-13	89	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030030n
		11532105	66003	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	432	6	1	2	5.8	O=C1Nc2ccc(F)cc2C1CCCCN1CC=C(c2cccc(C(F)(F)F)c2)CC1	10.1021/jm200547z
		CHEMBL1836792	66003	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	432	6	1	2	5.8	O=C1Nc2ccc(F)cc2C1CCCCN1CC=C(c2cccc(C(F)(F)F)c2)CC1	10.1021/jm200547z
		54758391	66010	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	401	6	1	3	4.5	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm200547z
		CHEMBL1836859	66010	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	401	6	1	3	4.5	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm200547z
		23369416	182487	2	None	-3	3	Human	7.4	pKi	=	7.4	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	366	6	1	5	2.6	COc1ccccc1N1CCN(CCCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
		CHEMBL478680	182487	2	None	-3	3	Human	7.4	pKi	=	7.4	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	366	6	1	5	2.6	COc1ccccc1N1CCN(CCCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
		155512406	169641	0	None	25	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	449	7	1	5	5.6	O=c1[nH]c(SCCCN2CCC(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
		CHEMBL4437211	169641	0	None	25	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	449	7	1	5	5.6	O=c1[nH]c(SCCCN2CCC(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
		11385992	84668	0	None	1	3	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	439	8	1	3	5.2	O=C(CCCCCN1CCN(c2ccccc2Cl)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
		CHEMBL222477	84668	0	None	1	3	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	439	8	1	3	5.2	O=C(CCCCCN1CCN(c2ccccc2Cl)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
		2389	3331	118	None	-7	67	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2020.112709
		5073	3331	118	None	-7	67	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2020.112709
		96	3331	118	None	-7	67	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2020.112709
		CHEMBL85	3331	118	None	-7	67	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2020.112709
		DB00734	3331	118	None	-7	67	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2020.112709
		44324643	207236	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	311	4	2	5	3.1	COc1ccc(-c2cccc(NC3=NCCN3)c2C)c(OC)c1	10.1016/s0960-894x(02)00925-3
		CHEMBL92856	207236	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	311	4	2	5	3.1	COc1ccc(-c2cccc(NC3=NCCN3)c2C)c(OC)c1	10.1016/s0960-894x(02)00925-3
		10596321	207464	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm030030n
		CHEMBL94261	207464	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm030030n
		156010130	177039	0	None	5	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	319	2	0	1	5.1	CN(C)C1CCc2c(cccc2-c2cc(Cl)cc(Cl)c2)C1	10.1016/j.bmc.2019.115262
		CHEMBL4632499	177039	0	None	5	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	319	2	0	1	5.1	CN(C)C1CCc2c(cccc2-c2cc(Cl)cc(Cl)c2)C1	10.1016/j.bmc.2019.115262
		59752589	179826	0	None	-26	4	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	323	2	1	3	4.1	CC(C)n1nc2c(c1-c1ccc(Cl)cc1Cl)CCNCC2	10.1016/j.bmcl.2020.127669
		CHEMBL4745055	179826	0	None	-26	4	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	323	2	1	3	4.1	CC(C)n1nc2c(c1-c1ccc(Cl)cc1Cl)CCNCC2	10.1016/j.bmcl.2020.127669
		44439398	91213	0	None	-1	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	408	5	0	5	4.4	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(OC(C)=O)CCC3)CC2	10.1016/j.bmcl.2007.01.093
		CHEMBL240022	91213	0	None	-1	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	408	5	0	5	4.4	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(OC(C)=O)CCC3)CC2	10.1016/j.bmcl.2007.01.093
		9950396	145123	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	352	4	1	4	3.4	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(O)CC3)CC2	10.1016/j.bmcl.2007.01.093
		CHEMBL391192	145123	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	352	4	1	4	3.4	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(O)CC3)CC2	10.1016/j.bmcl.2007.01.093
		59752584	181495	0	None	-128	4	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	323	2	1	3	4.1	CC(C)n1nc2c(c1-c1ccc(Cl)c(Cl)c1)CCNCC2	10.1016/j.bmcl.2020.127669
		CHEMBL4764808	181495	0	None	-128	4	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	323	2	1	3	4.1	CC(C)n1nc2c(c1-c1ccc(Cl)c(Cl)c1)CCNCC2	10.1016/j.bmcl.2020.127669
		155519045	170326	0	None	2	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	446	8	1	5	4.7	O=c1[nH]c(CCCCCN2CCN(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
		CHEMBL4446978	170326	0	None	2	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	446	8	1	5	4.7	O=c1[nH]c(CCCCCN2CCN(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
		118464420	138245	0	None	-67	8	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acs.jmedchem.5b01631
		CHEMBL3770342	138245	0	None	-67	8	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acs.jmedchem.5b01631
		53361627	66629	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	431	6	0	6	3.7	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2011.04.060
		CHEMBL1812288	66629	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	431	6	0	6	3.7	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2011.04.060
		CHEMBL1852767	66629	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	431	6	0	6	3.7	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2011.04.060
		155545088	176657	0	None	-5	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	6.0	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4528793	176657	0	None	-5	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	6.0	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4598089	176657	0	None	-5	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	6.0	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
		72550864	114079	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	491	10	1	4	5.6	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2cccc(Cl)c2)CC1	10.1016/j.bmc.2014.07.026
		CHEMBL3326983	114079	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	491	10	1	4	5.6	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2cccc(Cl)c2)CC1	10.1016/j.bmc.2014.07.026
		71462066	81166	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	386	8	1	4	4.4	CC(C)c1ccccc1OCCN1CCC(CNC(=O)c2cccs2)CC1	10.1016/j.ejmech.2012.07.043
		CHEMBL2158032	81166	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	386	8	1	4	4.4	CC(C)c1ccccc1OCCN1CCC(CNC(=O)c2cccs2)CC1	10.1016/j.ejmech.2012.07.043
		1353	1911	93	None	-263	83	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.ejmech.2018.01.002
		3559	1911	93	None	-263	83	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.ejmech.2018.01.002
		86	1911	93	None	-263	83	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.ejmech.2018.01.002
		CHEMBL54	1911	93	None	-263	83	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.ejmech.2018.01.002
		DB00502	1911	93	None	-263	83	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.ejmech.2018.01.002
		145975713	163942	0	None	10	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	472	7	1	4	3.9	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1ccc(Cl)cc1	10.1021/acs.jmedchem.8b00828
		CHEMBL4207633	163942	0	None	10	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	472	7	1	4	3.9	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1ccc(Cl)cc1	10.1021/acs.jmedchem.8b00828
		71451344	81163	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	406	7	1	3	4.4	Cc1ccccc1C(=O)NCC1CCN(CCOc2cccc3c2CCCC3)CC1	10.1016/j.ejmech.2012.07.043
		CHEMBL2158029	81163	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	406	7	1	3	4.4	Cc1ccccc1C(=O)NCC1CCN(CCOc2cccc3c2CCCC3)CC1	10.1016/j.ejmech.2012.07.043
		56851049	71503	0	None	-21	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	357	7	1	4	2.2	O=C1C2CCCN2C(=O)N1CCCCNC[C@H]1CCc2ccccc2O1	10.1021/jm2007886
		CHEMBL1926734	71503	0	None	-21	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	357	7	1	4	2.2	O=C1C2CCCN2C(=O)N1CCCCNC[C@H]1CCc2ccccc2O1	10.1021/jm2007886
		CHEMBL1962693	71503	0	None	-21	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	357	7	1	4	2.2	O=C1C2CCCN2C(=O)N1CCCCNC[C@H]1CCc2ccccc2O1	10.1021/jm2007886
		76328892	106414	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	392	4	0	4	4.8	N#Cc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
		CHEMBL3121429	106414	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	392	4	0	4	4.8	N#Cc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
		CHEMBL3139511	106414	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	392	4	0	4	4.8	N#Cc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
		57390337	68435	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	482	10	0	6	3.9	CCN(CCCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1ccc2ncccc2c1	10.1016/j.bmc.2011.09.044
		CHEMBL1917356	68435	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	482	10	0	6	3.9	CCN(CCCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1ccc2ncccc2c1	10.1016/j.bmc.2011.09.044
		71462178	81426	0	None	-1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	437	7	1	4	4.8	O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc2ccccc2n1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159469	81426	0	None	-1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	437	7	1	4	4.8	O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc2ccccc2n1	10.1016/j.ejmech.2012.07.043
		71574298	86285	0	None	1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	526	8	1	5	5.1	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccc(Cl)cc2c1	10.1016/j.ejmech.2012.11.042
		CHEMBL2312936	86285	0	None	1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	526	8	1	5	5.1	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccc(Cl)cc2c1	10.1016/j.ejmech.2012.11.042
		145976158	163842	0	None	53	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
		CHEMBL4206468	163842	0	None	53	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
		118706278	120523	0	None	-26	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(Cl)c1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3310109	120523	0	None	-26	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(Cl)c1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3545439	120523	0	None	-26	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(Cl)c1-2	10.1016/j.bmc.2014.05.027
		118706292	120534	0	None	-6	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	297	2	4	3	0.7	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(CO)c1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3310117	120534	0	None	-6	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	297	2	4	3	0.7	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(CO)c1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3545469	120534	0	None	-6	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	297	2	4	3	0.7	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(CO)c1-2	10.1016/j.bmc.2014.05.027
		118709754	113545	0	None	12	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	340	6	0	2	4.3	O=C1Cc2ccccc2N1CCCCCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
		CHEMBL3321796	113545	0	None	12	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	340	6	0	2	4.3	O=C1Cc2ccccc2N1CCCCCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
		66801116	112094	0	None	81	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	457	7	1	8	2.9	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
		CHEMBL3289988	112094	0	None	81	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	457	7	1	8	2.9	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
		11785995	84352	0	None	-1	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	465	10	1	5	4.6	COc1ccc2c(c1)C(NC(=O)CCCCCN1CCN(c3ccccc3OC)CC1)CCC2	10.1021/jm049702f
		CHEMBL221732	84352	0	None	-1	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	465	10	1	5	4.6	COc1ccc2c(c1)C(NC(=O)CCCCCN1CCN(c3ccccc3OC)CC1)CCC2	10.1021/jm049702f
		44437327	90867	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	650	15	0	8	5.9	COc1ccccc1N1CCN(CCc2cccc(OCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		CHEMBL239231	90867	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	650	15	0	8	5.9	COc1ccccc1N1CCN(CCc2cccc(OCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		118713590	114375	0	None	16	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	381	7	0	5	3.7	O=c1sc2ccccc2n1CCCCN1CCN(Cc2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
		CHEMBL3331259	114375	0	None	16	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	381	7	0	5	3.7	O=c1sc2ccccc2n1CCCCN1CCN(Cc2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
		162675477	183442	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	464	6	0	4	5.4	COc1ccc(-c2ccccc2N2CCN(CC#CCOc3ccc(Cl)c(F)c3)CC2)cc1	10.1016/j.ejmech.2020.112395
		CHEMBL4798874	183442	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	464	6	0	4	5.4	COc1ccc(-c2ccccc2N2CCN(CC#CCOc3ccc(Cl)c(F)c3)CC2)cc1	10.1016/j.ejmech.2020.112395
		44424653	142090	0	None	-4	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	456	8	0	10	1.1	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2007.05.017
		CHEMBL388133	142090	0	None	-4	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	456	8	0	10	1.1	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2007.05.017
		46204730	124569	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	273	3	1	2	3.7	Cc1cccc(-c2ccc(Cl)c(OC3CNC3)c2)c1	nan
		CHEMBL3640576	124569	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	273	3	1	2	3.7	Cc1cccc(-c2ccc(Cl)c(OC3CNC3)c2)c1	nan
		46204730	124569	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	273	3	1	2	3.7	Cc1cccc(-c2ccc(Cl)c(OC3CNC3)c2)c1	nan
		CHEMBL3640576	124569	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	273	3	1	2	3.7	Cc1cccc(-c2ccc(Cl)c(OC3CNC3)c2)c1	nan
		130442572	171908	0	None	-87	24	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4469848	171908	0	None	-87	24	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		19958507	99421	0	None	-81	5	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	320	4	1	3	3.4	CCc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1	10.1016/s0960-894x(01)00241-4
		CHEMBL282829	99421	0	None	-81	5	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	320	4	1	3	3.4	CCc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1	10.1016/s0960-894x(01)00241-4
		46233353	202345	3	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	259	4	0	2	3.1	CN(C)CCSc1ccccc1Br	10.1016/j.bmc.2010.01.035
		CHEMBL610515	202345	3	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	259	4	0	2	3.1	CN(C)CCSc1ccccc1Br	10.1016/j.bmc.2010.01.035
		136118617	76249	0	None	-4	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1\NC(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1C	10.1016/j.bmc.2013.09.011
		CHEMBL2058416	76249	0	None	-4	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1\NC(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1C	10.1016/j.bmc.2013.09.011
		10267394	100389	3	None	-181	4	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	310	3	1	3	3.0	Fc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1	10.1016/s0960-894x(01)00241-4
		CHEMBL28997	100389	3	None	-181	4	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	310	3	1	3	3.0	Fc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1	10.1016/s0960-894x(01)00241-4
		57399432	70465	0	None	-14	8	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	399	6	0	4	5.5	Clc1ccc(N2CCCN(CCCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.ejmech.2012.03.042
		CHEMBL1946254	70465	0	None	-14	8	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	399	6	0	4	5.5	Clc1ccc(N2CCCN(CCCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.ejmech.2012.03.042
		90469187	186008	0	None	-1380	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	406	3	1	6	3.1	Cc1cccc(S(=O)(=O)n2ccc3c(N4CCNCC4)nc4ccccc4c32)c1	10.1021/acs.jmedchem.1c00224
		CHEMBL4870374	186008	0	None	-1380	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	406	3	1	6	3.1	Cc1cccc(S(=O)(=O)n2ccc3c(N4CCNCC4)nc4ccccc4c32)c1	10.1021/acs.jmedchem.1c00224
		71462065	81164	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	424	7	1	3	4.7	O=C(NCC1CCN(CCOc2cc(Cl)ccc2Cl)CC1)c1cccc(F)c1	10.1016/j.ejmech.2012.07.043
		CHEMBL2158030	81164	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	424	7	1	3	4.7	O=C(NCC1CCN(CCOc2cc(Cl)ccc2Cl)CC1)c1cccc(F)c1	10.1016/j.ejmech.2012.07.043
		145976698	163945	0	None	5	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2ccccc2Br)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
		CHEMBL4207656	163945	0	None	5	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2ccccc2Br)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
		90654695	110081	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	422	6	1	5	2.1	COc1ccccc1N1CCN(Cc2ccc(C(=O)N3CCC[C@H]3C(N)=O)cc2)CC1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235732	110081	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	422	6	1	5	2.1	COc1ccccc1N1CCN(Cc2ccc(C(=O)N3CCC[C@H]3C(N)=O)cc2)CC1	10.1016/j.ejmech.2014.03.005
		11048252	204182	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	429	7	2	3	4.3	NC(=O)c1ccc2c3c1CCCC3(CCCCN1CC=C(c3ccccc3)CC1)C(=O)N2	10.1021/jm0104264
		CHEMBL70764	204182	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	429	7	2	3	4.3	NC(=O)c1ccc2c3c1CCCC3(CCCCN1CC=C(c3ccccc3)CC1)C(=O)N2	10.1021/jm0104264
		168296329	192438	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	359	3	2	4	2.7	O=c1[nH]c2cccc(N3CCN(Cc4ccc5ccccc5n4)CC3)c2[nH]1	10.1016/j.ejmech.2022.114218
		CHEMBL5208347	192438	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	359	3	2	4	2.7	O=c1[nH]c2cccc(N3CCN(Cc4ccc5ccccc5n4)CC3)c2[nH]1	10.1016/j.ejmech.2022.114218
		164628177	188611	0	None	-4	7	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	366	7	1	5	2.8	CC(=O)Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
		CHEMBL4875079	188611	0	None	-4	7	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	366	7	1	5	2.8	CC(=O)Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
		CHEMBL5029038	188611	0	None	-4	7	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	366	7	1	5	2.8	CC(=O)Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
		CHEMBL5079536	214622	0	None	-60	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		Cc1c(S(=O)(=O)N[C@H]2C[C@H](C)N(CCCc3noc4cc(F)ccc34)C2)sc2ccc(Cl)cc12	10.1021/acs.jmedchem.1c00497
		56850658	71520	0	None	-19	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	371	7	1	4	1.6	O=C1C2CCCN2C(=O)CN1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
		CHEMBL1926745	71520	0	None	-19	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	371	7	1	4	1.6	O=C1C2CCCN2C(=O)CN1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
		CHEMBL1962804	71520	0	None	-19	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	371	7	1	4	1.6	O=C1C2CCCN2C(=O)CN1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
		53377324	66647	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	481	6	0	6	4.6	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.ejmech.2011.04.060
		CHEMBL1812290	66647	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	481	6	0	6	4.6	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.ejmech.2011.04.060
		CHEMBL1852853	66647	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	481	6	0	6	4.6	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.ejmech.2011.04.060
		135458672	117933	10	None	-1	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	387	3	2	3	4.1	Cc1ccc(S(=O)(=O)N/N=C2\CCCc3c2[nH]c2ccc(Cl)cc32)cc1	10.1016/j.bmcl.2015.03.049
		CHEMBL3403337	117933	10	None	-1	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	387	3	2	3	4.1	Cc1ccc(S(=O)(=O)N/N=C2\CCCc3c2[nH]c2ccc(Cl)cc32)cc1	10.1016/j.bmcl.2015.03.049
		45113400	14231	2	None	-19	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity to 5HT7 receptor by radioligand displacement assayBinding affinity to 5HT7 receptor by radioligand displacement assay	ChEMBL	359	3	2	3	3.1	CN1CCc2[nH]c3ccc(S(=O)(=O)Nc4cccc(F)c4)cc3c2C1	10.1016/j.ejmech.2009.10.035
		CHEMBL1099284	14231	2	None	-19	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity to 5HT7 receptor by radioligand displacement assayBinding affinity to 5HT7 receptor by radioligand displacement assay	ChEMBL	359	3	2	3	3.1	CN1CCc2[nH]c3ccc(S(=O)(=O)Nc4cccc(F)c4)cc3c2C1	10.1016/j.ejmech.2009.10.035
		CHEMBL1199172	14231	2	None	-19	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity to 5HT7 receptor by radioligand displacement assayBinding affinity to 5HT7 receptor by radioligand displacement assay	ChEMBL	359	3	2	3	3.1	CN1CCc2[nH]c3ccc(S(=O)(=O)Nc4cccc(F)c4)cc3c2C1	10.1016/j.ejmech.2009.10.035
		138691329	170723	0	None	100	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	245	2	1	2	3.7	CCn1cncc1-c1c[nH]c2ccc(Cl)cc12	10.1016/j.ejmech.2019.03.017
		CHEMBL4452121	170723	0	None	100	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	245	2	1	2	3.7	CCn1cncc1-c1c[nH]c2ccc(Cl)cc12	10.1016/j.ejmech.2019.03.017
		127040444	136781	0	None	6	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	402	8	1	4	3.6	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccccc2)CC1	10.1039/C5MD00166H
		CHEMBL3741279	136781	0	None	6	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	402	8	1	4	3.6	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccccc2)CC1	10.1039/C5MD00166H
		156018601	177894	0	None	9	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	414	6	1	5	3.4	C=CCOc1c(OC)cc2c3c1-c1cc(NS(C)(=O)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
		CHEMBL4644833	177894	0	None	9	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	414	6	1	5	3.4	C=CCOc1c(OC)cc2c3c1-c1cc(NS(C)(=O)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
		118051679	170149	0	None	-3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	480	9	1	7	2.8	COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
		CHEMBL4444280	170149	0	None	-3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	480	9	1	7	2.8	COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
		59395105	106340	1	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	252	1	3	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)[nH]c1ccccc12	10.1016/j.bmc.2013.10.010
		CHEMBL3092755	106340	1	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	252	1	3	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)[nH]c1ccccc12	10.1016/j.bmc.2013.10.010
		CHEMBL3139187	106340	1	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	252	1	3	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)[nH]c1ccccc12	10.1016/j.bmc.2013.10.010
		25108474	193200	0	None	-38	3	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	423	8	0	4	4.6	CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	10.1021/jm800615e
		CHEMBL523381	193200	0	None	-38	3	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	423	8	0	4	4.6	CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	10.1021/jm800615e
		44437330	152189	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	706	19	0	8	7.5	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		CHEMBL396844	152189	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	706	19	0	8	7.5	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		71602692	89689	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccccc1-c1ccccc1CN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2013.02.038
		CHEMBL2376461	89689	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccccc1-c1ccccc1CN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2013.02.038
		162651292	180222	0	None	-33	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	438	7	1	6	3.3	Cn1ccc2c(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)cccc21	10.1016/j.ejmech.2020.112149
		CHEMBL4749824	180222	0	None	-33	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	438	7	1	6	3.3	Cn1ccc2c(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)cccc21	10.1016/j.ejmech.2020.112149
		162666019	182300	0	None	3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	532	9	0	6	6.4	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc4c(C)cc(=O)oc4c3Cl)CC2)cc1	10.1016/j.ejmech.2020.112395
		CHEMBL4784089	182300	0	None	3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	532	9	0	6	6.4	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc4c(C)cc(=O)oc4c3Cl)CC2)cc1	10.1016/j.ejmech.2020.112395
		164628177	188611	0	None	-4	7	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	366	7	1	5	2.8	CC(=O)Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
		CHEMBL4875079	188611	0	None	-4	7	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	366	7	1	5	2.8	CC(=O)Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
		CHEMBL5029038	188611	0	None	-4	7	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	366	7	1	5	2.8	CC(=O)Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
		155551114	176670	0	None	-6	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	431	8	0	3	5.3	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2F)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4541606	176670	0	None	-6	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	431	8	0	3	5.3	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2F)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4598210	176670	0	None	-6	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	431	8	0	3	5.3	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2F)CC1	10.1016/j.bmc.2019.06.028
		13091356	113538	0	None	-102	8	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	389	6	1	3	4.8	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCOc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
		CHEMBL3321789	113538	0	None	-102	8	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	389	6	1	3	4.8	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCOc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
		155529153	171401	0	None	-38	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	378	4	1	6	0.3	CC([Se]c1ccccc1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
		CHEMBL4462404	171401	0	None	-38	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	378	4	1	6	0.3	CC([Se]c1ccccc1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
		135367855	164382	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1ccccc1-c1noc2c1CCNCC2	10.1021/acs.jmedchem.8b00642
		CHEMBL4213067	164382	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1ccccc1-c1noc2c1CCNCC2	10.1021/acs.jmedchem.8b00642
		60165541	75346	0	None	-9	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	364	6	0	4	5.1	O=C(CCCN1CCC(c2ccccc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
		CHEMBL2037518	75346	0	None	-9	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	364	6	0	4	5.1	O=C(CCCN1CCC(c2ccccc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
		24768523	143680	0	None	-4	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	498	10	2	5	3.9	CS(=O)(=O)Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
		CHEMBL390015	143680	0	None	-4	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	498	10	2	5	3.9	CS(=O)(=O)Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
		71727069	102405	0	None	-3	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	400	4	0	5	4.3	COc1ccccc1N1CCN(Cc2ccc3oc4ccccc4c(=O)c3c2)CC1	10.1016/j.bmcl.2013.05.062
		CHEMBL2401935	102405	0	None	-3	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	400	4	0	5	4.3	COc1ccccc1N1CCN(Cc2ccc3oc4ccccc4c(=O)c3c2)CC1	10.1016/j.bmcl.2013.05.062
		CHEMBL3039672	102405	0	None	-3	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	400	4	0	5	4.3	COc1ccccc1N1CCN(Cc2ccc3oc4ccccc4c(=O)c3c2)CC1	10.1016/j.bmcl.2013.05.062
		135367855	164382	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1ccccc1-c1noc2c1CCNCC2	10.1021/acs.jmedchem.8b00642
		CHEMBL4213067	164382	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1ccccc1-c1noc2c1CCNCC2	10.1021/acs.jmedchem.8b00642
		71462155	81368	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	408	6	1	3	4.9	Cc1ccccc1C(=O)NC1CCN(CCSc2cccc(Cl)c2Cl)C1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159316	81368	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	408	6	1	3	4.9	Cc1ccccc1C(=O)NC1CCN(CCSc2cccc(Cl)c2Cl)C1	10.1016/j.ejmech.2012.07.043
		118464427	138334	0	None	-15	7	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	328	3	4	6	1.8	CCNC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
		CHEMBL3771331	138334	0	None	-15	7	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	328	3	4	6	1.8	CCNC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
		168282819	191210	0	None	2	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	419	10	4	8	3.1	COc1ccccc1OCCNc1nc(N)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
		CHEMBL5189520	191210	0	None	2	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	419	10	4	8	3.1	COc1ccccc1OCCNc1nc(N)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
		11142729	119733	0	None	3	2	Rat	7.4	pKi	=	7.4	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	352	8	1	4	4.0	O=C(CCCCCN1CCN(c2ccccc2)CC1)c1ccccc1O	10.1021/jm020994z
		CHEMBL347629	119733	0	None	3	2	Rat	7.4	pKi	=	7.4	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	352	8	1	4	4.0	O=C(CCCCCN1CCN(c2ccccc2)CC1)c1ccccc1O	10.1021/jm020994z
		1613	2348	53	None	-14	44	Rat	7.4	pKi	=	7.4	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm030030n
		205	2348	53	None	-14	44	Rat	7.4	pKi	=	7.4	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm030030n
		3964	2348	53	None	-14	44	Rat	7.4	pKi	=	7.4	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm030030n
		CHEMBL831	2348	53	None	-14	44	Rat	7.4	pKi	=	7.4	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm030030n
		DB00408	2348	53	None	-14	44	Rat	7.4	pKi	=	7.4	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm030030n
		24944943	102510	0	None	-17	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	381	9	1	4	3.0	O=C1C2CCCN2C(=O)N1CCCCNCCOc1cccc2ccccc12	10.1021/jm400766k
		CHEMBL2431038	102510	0	None	-17	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	381	9	1	4	3.0	O=C1C2CCCN2C(=O)N1CCCCNCCOc1cccc2ccccc12	10.1021/jm400766k
		CHEMBL3040400	102510	0	None	-17	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	381	9	1	4	3.0	O=C1C2CCCN2C(=O)N1CCCCNCCOc1cccc2ccccc12	10.1021/jm400766k
		122181346	121888	0	None	2	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	494	7	1	4	4.9	O=C1NC2(CCCCC2c2ccccc2)C(=O)N1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2015.04.026
		CHEMBL3590098	121888	0	None	2	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	494	7	1	4	4.9	O=C1NC2(CCCCC2c2ccccc2)C(=O)N1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2015.04.026
		145977256	163549	0	None	1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	391	4	1	3	3.5	O=C1Nc2ccccc2C12CCN(CCN1CC=C(c3ccc(F)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
		CHEMBL4202947	163549	0	None	1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	391	4	1	3	3.5	O=C1Nc2ccccc2C12CCN(CCN1CC=C(c3ccc(F)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
		118731350	118187	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	490	10	1	4	4.3	CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.12.041
		CHEMBL3409034	118187	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	490	10	1	4	4.3	CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.12.041
		71602692	89689	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccccc1-c1ccccc1CN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2013.02.038
		CHEMBL2376461	89689	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccccc1-c1ccccc1CN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2013.02.038
		23151712	120536	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	266	1	3	2	1.1	NC(N)=NC(=O)c1ccc2c(c1)C(N)c1ccccc1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3310120	120536	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	266	1	3	2	1.1	NC(N)=NC(=O)c1ccc2c(c1)C(N)c1ccccc1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3545471	120536	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	266	1	3	2	1.1	NC(N)=NC(=O)c1ccc2c(c1)C(N)c1ccccc1-2	10.1016/j.bmc.2014.05.027
		118736369	118941	0	None	-4	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	541	8	1	10	3.1	Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccccc5O)CC4)c(-c4ccccc4)cn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
		CHEMBL3423333	118941	0	None	-4	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	541	8	1	10	3.1	Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccccc5O)CC4)c(-c4ccccc4)cn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
		16754	85574	50	None	2	7	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	355	4	0	5	3.5	COc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
		CHEMBL228082	85574	50	None	2	7	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	355	4	0	5	3.5	COc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
		44437335	151657	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	722	16	0	11	5.0	COc1ccccc1N1CCN(CCc2cccc(OC(=O)COCC(=O)Oc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		CHEMBL396396	151657	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	722	16	0	11	5.0	COc1ccccc1N1CCN(CCc2cccc(OC(=O)COCC(=O)Oc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		10593348	97295	0	None	4	4	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	341	1	1	2	5.1	Cc1cccc(O)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0108505
		CHEMBL26907	97295	0	None	4	4	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	341	1	1	2	5.1	Cc1cccc(O)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0108505
		11375902	166233	0	None	-1	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	451	9	1	5	4.2	COc1ccc2c(c1)CCCC2NC(=O)CCCCN1CCN(c2ccccc2OC)CC1	10.1021/jm049702f
		CHEMBL426723	166233	0	None	-1	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	451	9	1	5	4.2	COc1ccc2c(c1)CCCC2NC(=O)CCCCN1CCN(c2ccccc2OC)CC1	10.1021/jm049702f
		11121721	119752	0	None	-6	2	Rat	7.4	pKi	=	7.4	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	352	8	0	4	3.9	COc1ccccc1N1CCN(CCCCC(=O)c2ccccc2)CC1	10.1021/jm020994z
		CHEMBL347837	119752	0	None	-6	2	Rat	7.4	pKi	=	7.4	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	352	8	0	4	3.9	COc1ccccc1N1CCN(CCCCC(=O)c2ccccc2)CC1	10.1021/jm020994z
		11058564	102073	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	404	6	2	3	4.4	O=C1Nc2cccc3c2C1(CCCCN1CCC(O)(c2ccccc2)CC1)CCC3	10.1021/jm0104264
		CHEMBL302093	102073	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	404	6	2	3	4.4	O=C1Nc2cccc3c2C1(CCCCN1CCC(O)(c2ccccc2)CC1)CCC3	10.1021/jm0104264
		134146195	154591	0	None	-3	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	362	5	0	3	5.8	Clc1ccc2sc(CCCCN3CCC4CCCCC4C3)nc2c1	10.1016/j.bmc.2016.09.019
		CHEMBL3941795	154591	0	None	-3	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	362	5	0	3	5.8	Clc1ccc2sc(CCCCN3CCC4CCCCC4C3)nc2c1	10.1016/j.bmc.2016.09.019
		CHEMBL3991399	154591	0	None	-3	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	362	5	0	3	5.8	Clc1ccc2sc(CCCCN3CCC4CCCCC4C3)nc2c1	10.1016/j.bmc.2016.09.019
		CHEMBL5088232	215146	0	None	-28	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		C[C@H]1C[C@H](NS(=O)(=O)c2ccc3ccccc3c2)CN1CCCc1noc2cc(F)ccc12	10.1021/acs.jmedchem.1c00497
		72549988	114074	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	471	11	1	4	5.4	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2014.07.026
		CHEMBL3326978	114074	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	471	11	1	4	5.4	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2014.07.026
		72547876	114083	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	487	11	1	5	5.0	COc1ccc(-c2ccccc2CNC(=O)CCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2014.07.026
		CHEMBL3326987	114083	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	487	11	1	5	5.0	COc1ccc(-c2ccccc2CNC(=O)CCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2014.07.026
		155540755	172944	0	None	-3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	432	7	1	6	3.8	COc1ccc(Cl)cc1N1CCN(CCCCc2nc3ccsc3c(=O)[nH]2)CC1	10.1016/j.ejmech.2019.111690
		CHEMBL4516999	172944	0	None	-3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	432	7	1	6	3.8	COc1ccc(Cl)cc1N1CCN(CCCCc2nc3ccsc3c(=O)[nH]2)CC1	10.1016/j.ejmech.2019.111690
		46205701	124595	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	251	2	0	1	4.1	Cc1ccc(-c2ccccc2C2CCN(C)C2)cc1	nan
		CHEMBL3640601	124595	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	251	2	0	1	4.1	Cc1ccc(-c2ccccc2C2CCN(C)C2)cc1	nan
		46205701	124595	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	251	2	0	1	4.1	Cc1ccc(-c2ccccc2C2CCN(C)C2)cc1	nan
		CHEMBL3640601	124595	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	251	2	0	1	4.1	Cc1ccc(-c2ccccc2C2CCN(C)C2)cc1	nan
		71602583	89692	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	358	5	0	3	4.7	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2013.02.038
		CHEMBL2376469	89692	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	358	5	0	3	4.7	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2013.02.038
		155522563	176656	0	None	-9	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	483	8	0	4	5.4	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4453687	176656	0	None	-9	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	483	8	0	4	5.4	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4598088	176656	0	None	-9	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	483	8	0	4	5.4	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
		162674779	183779	0	None	-10	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	10	1	4	5.1	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4798599	183779	0	None	-10	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	10	1	4	5.1	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4804025	183779	0	None	-10	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	10	1	4	5.1	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
		13069611	120611	0	None	-363	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	426	7	0	9	1.0	COc1ccccc1N1CCN(CCCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1	10.1016/j.bmc.2014.11.008
		CHEMBL3360995	120611	0	None	-363	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	426	7	0	9	1.0	COc1ccccc1N1CCN(CCCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1	10.1016/j.bmc.2014.11.008
		CHEMBL3546110	120611	0	None	-363	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	426	7	0	9	1.0	COc1ccccc1N1CCN(CCCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1	10.1016/j.bmc.2014.11.008
		90656684	110976	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	375	6	1	4	4.2	CN(CCCN1CCN(c2ccc3ccccc3c2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262409	110976	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	375	6	1	4	4.2	CN(CCCN1CCN(c2ccc3ccccc3c2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		71602583	89692	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	358	5	0	3	4.7	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2013.02.038
		CHEMBL2376469	89692	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	358	5	0	3	4.7	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2013.02.038
		137646045	157789	0	None	-436	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)	ChEMBL	404	4	0	5	4.3	CN(C)CC1=Cc2cn(S(=O)(=O)c3cccc4ccccc34)c3cccc(c23)O1	10.1021/acsmedchemlett.6b00482
		CHEMBL4083059	157789	0	None	-436	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)	ChEMBL	404	4	0	5	4.3	CN(C)CC1=Cc2cn(S(=O)(=O)c3cccc4ccccc34)c3cccc(c23)O1	10.1021/acsmedchemlett.6b00482
		242	470	124	None	-15	51	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2018.01.002
		34	470	124	None	-15	51	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2018.01.002
		60795	470	124	None	-15	51	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2018.01.002
		CHEMBL1112	470	124	None	-15	51	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2018.01.002
		DB01238	470	124	None	-15	51	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2018.01.002
		134146185	148837	0	None	18	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	512	10	1	5	4.6	O=C(CCOCCN1CCN(c2cccnc2-c2ccccc2)CC1)NCc1ccc(C(F)(F)F)cc1	10.1016/j.ejmech.2016.05.005
		CHEMBL3941102	148837	0	None	18	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	512	10	1	5	4.6	O=C(CCOCCN1CCN(c2cccnc2-c2ccccc2)CC1)NCc1ccc(C(F)(F)F)cc1	10.1016/j.ejmech.2016.05.005
		138691362	170951	0	None	48	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	225	2	1	2	3.4	CCn1cncc1-c1c[nH]c2ccc(C)cc12	10.1016/j.ejmech.2019.03.017
		CHEMBL4455588	170951	0	None	48	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	225	2	1	2	3.4	CCn1cncc1-c1c[nH]c2ccc(C)cc12	10.1016/j.ejmech.2019.03.017
		127038034	136669	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	416	9	1	4	3.8	CC(C)CS(=O)(=O)NC1CCN(CCOc2ccccc2-c2ccccc2)CC1	10.1039/C5MD00166H
		CHEMBL3740209	136669	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	416	9	1	4	3.8	CC(C)CS(=O)(=O)NC1CCN(CCOc2ccccc2-c2ccccc2)CC1	10.1039/C5MD00166H
		134146195	154591	0	None	-3	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	362	5	0	3	5.8	Clc1ccc2sc(CCCCN3CCC4CCCCC4C3)nc2c1	10.1016/j.bmc.2016.09.019
		CHEMBL3941795	154591	0	None	-3	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	362	5	0	3	5.8	Clc1ccc2sc(CCCCN3CCC4CCCCC4C3)nc2c1	10.1016/j.bmc.2016.09.019
		CHEMBL3991399	154591	0	None	-3	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	362	5	0	3	5.8	Clc1ccc2sc(CCCCN3CCC4CCCCC4C3)nc2c1	10.1016/j.bmc.2016.09.019
		24854106	161061	1	None	-2	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	367	6	1	3	3.9	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm070279v
		CHEMBL411663	161061	1	None	-2	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	367	6	1	3	3.9	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm070279v
		162668734	182604	0	None	5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	470	8	1	5	4.7	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccc(Cl)cc3F)CC2)cc1	10.1016/j.ejmech.2020.112395
		CHEMBL4788259	182604	0	None	5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	470	8	1	5	4.7	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccc(Cl)cc3F)CC2)cc1	10.1016/j.ejmech.2020.112395
		134133968	154523	0	None	-1	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1cccc2c1CN(CCCCc1nc3ccccc3s1)CC2	10.1016/j.bmc.2016.09.019
		CHEMBL3899099	154523	0	None	-1	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1cccc2c1CN(CCCCc1nc3ccccc3s1)CC2	10.1016/j.bmc.2016.09.019
		CHEMBL3990801	154523	0	None	-1	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1cccc2c1CN(CCCCc1nc3ccccc3s1)CC2	10.1016/j.bmc.2016.09.019
		132547275	142243	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	436	9	0	5	5.2	Clc1cccc(N2CCN(CCCCCOc3cc(-c4ccccc4)ncn3)CC2)c1	10.1016/j.bmc.2016.12.039
		CHEMBL3884714	142243	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	436	9	0	5	5.2	Clc1cccc(N2CCN(CCCCCOc3cc(-c4ccccc4)ncn3)CC2)c1	10.1016/j.bmc.2016.12.039
		44424664	85715	0	None	-4	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	411	7	0	8	1.7	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCc2ccccc2C1	10.1016/j.bmc.2007.05.017
		CHEMBL228881	85715	0	None	-4	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	411	7	0	8	1.7	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCc2ccccc2C1	10.1016/j.bmc.2007.05.017
		73349361	92548	0	None	-5	7	Human	5.4	pKi	=	5.4	Binding	Inhibition of 5-HT7 receptor (unknown origin) by PDSP assayInhibition of 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	279	4	0	1	3.3	CN(CCc1ccccc1)[C@H]1C2C3CC4C5C3CC2C5C41	10.1016/j.bmc.2013.07.045
		CHEMBL2432058	92548	0	None	-5	7	Human	5.4	pKi	=	5.4	Binding	Inhibition of 5-HT7 receptor (unknown origin) by PDSP assayInhibition of 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	279	4	0	1	3.3	CN(CCc1ccccc1)[C@H]1C2C3CC4C5C3CC2C5C41	10.1016/j.bmc.2013.07.045
		76332581	106413	0	None	-2	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	417	4	0	3	6.1	c1ccc(N2CCN(Cc3cn(-c4ccc5ccccc5c4)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
		CHEMBL3121426	106413	0	None	-2	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	417	4	0	3	6.1	c1ccc(N2CCN(Cc3cn(-c4ccc5ccccc5c4)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
		CHEMBL3139510	106413	0	None	-2	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	417	4	0	3	6.1	c1ccc(N2CCN(Cc3cn(-c4ccc5ccccc5c4)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
		53325850	57011	0	None	-	1	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	356	3	1	2	5.2	Clc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1Cl	10.1016/j.bmcl.2010.11.078
		CHEMBL1644271	57011	0	None	-	1	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	356	3	1	2	5.2	Clc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1Cl	10.1016/j.bmcl.2010.11.078
		5074	3332	80	None	-69	30	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030030n
		97	3332	80	None	-69	30	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030030n
		CHEMBL267777	3332	80	None	-69	30	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030030n
		DB12693	3332	80	None	-69	30	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030030n
		145983059	165645	0	None	-6	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	492	6	0	6	4.4	O=S(=O)(c1cccc2ncccc12)N1CC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4243932	165645	0	None	-6	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	492	6	0	6	4.4	O=S(=O)(c1cccc2ncccc12)N1CC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
		90654846	112696	0	None	4	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	466	9	0	4	4.4	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.01.065
		CHEMBL3233672	112696	0	None	4	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	466	9	0	4	4.4	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.01.065
		CHEMBL3304317	112696	0	None	4	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	466	9	0	4	4.4	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.01.065
		134133968	154523	0	None	-1	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1cccc2c1CN(CCCCc1nc3ccccc3s1)CC2	10.1016/j.bmc.2016.09.019
		CHEMBL3899099	154523	0	None	-1	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1cccc2c1CN(CCCCc1nc3ccccc3s1)CC2	10.1016/j.bmc.2016.09.019
		CHEMBL3990801	154523	0	None	-1	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1cccc2c1CN(CCCCc1nc3ccccc3s1)CC2	10.1016/j.bmc.2016.09.019
		164621388	185736	0	None	-7	7	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	341	4	0	3	3.7	Clc1ccc2c(c1)CC(CCN1CCN(c3ccccn3)CC1)C2	10.1016/j.ejmech.2021.113243
		CHEMBL4866058	185736	0	None	-7	7	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	341	4	0	3	3.7	Clc1ccc2c(c1)CC(CCN1CCN(c3ccccn3)CC1)C2	10.1016/j.ejmech.2021.113243
		53323115	57019	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	306	3	1	2	4.0	Fc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
		CHEMBL1644279	57019	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	306	3	1	2	4.0	Fc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
		44439390	147804	0	None	33	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	322	4	2	3	3.6	COc1cccc(CC2NCCc3c2[nH]c2ccc(OC)cc32)c1	10.1016/j.bmcl.2007.01.093
		CHEMBL393275	147804	0	None	33	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	322	4	2	3	3.6	COc1cccc(CC2NCCc3c2[nH]c2ccc(OC)cc32)c1	10.1016/j.bmcl.2007.01.093
		132547278	142248	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	446	10	0	6	4.3	CCOc1ccccc1N1CCN(CCCCCn2cnc(-c3ccccc3)cc2=O)CC1	10.1016/j.bmc.2016.12.039
		CHEMBL3884778	142248	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	446	10	0	6	4.3	CCOc1ccccc1N1CCN(CCCCCn2cnc(-c3ccccc3)cc2=O)CC1	10.1016/j.bmc.2016.12.039
		76284455	105011	0	None	5	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	491	11	1	5	4.3	COc1ccc(CNC(=O)CCOCCN2CCN(c3ccccc3-c3ccc(F)cc3)CC2)cc1	10.1016/j.bmc.2014.01.016
		CHEMBL3113600	105011	0	None	5	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	491	11	1	5	4.3	COc1ccc(CNC(=O)CCOCCN2CCN(c3ccccc3-c3ccc(F)cc3)CC2)cc1	10.1016/j.bmc.2014.01.016
		135398737	958	93	None	-13	89	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/acsmedchemlett.6b00482
		38	958	93	None	-13	89	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/acsmedchemlett.6b00482
		722	958	93	None	-13	89	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/acsmedchemlett.6b00482
		CHEMBL42	958	93	None	-13	89	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/acsmedchemlett.6b00482
		DB00363	958	93	None	-13	89	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/acsmedchemlett.6b00482
		135398737	958	93	None	-13	89	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.111857
		38	958	93	None	-13	89	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.111857
		722	958	93	None	-13	89	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.111857
		CHEMBL42	958	93	None	-13	89	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.111857
		DB00363	958	93	None	-13	89	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.111857
		118713685	114390	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	393	9	0	5	4.4	O=c1oc2ccccc2n1CCCCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
		CHEMBL3331388	114390	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	393	9	0	5	4.4	O=c1oc2ccccc2n1CCCCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
		6603866	97429	17	None	-39	9	Rat	7.3	pKi	=	7.3	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1	10.1021/jm030826m
		CHEMBL26998	97429	17	None	-39	9	Rat	7.3	pKi	=	7.3	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1	10.1021/jm030826m
		CHEMBL541268	97429	17	None	-39	9	Rat	7.3	pKi	=	7.3	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1	10.1021/jm030826m
		11058267	204407	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	391	6	1	5	3.0	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ncccn2)CC1)CCC3	10.1021/jm0104264
		CHEMBL72008	204407	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	391	6	1	5	3.0	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ncccn2)CC1)CCC3	10.1021/jm0104264
		71602740	89617	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccc(-c2ccccc2CN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2013.02.038
		CHEMBL2375370	89617	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccc(-c2ccccc2CN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2013.02.038
		164621388	185736	0	None	-7	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	341	4	0	3	3.7	Clc1ccc2c(c1)CC(CCN1CCN(c3ccccn3)CC1)C2	10.1016/j.ejmech.2021.113243
		CHEMBL4866058	185736	0	None	-7	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	341	4	0	3	3.7	Clc1ccc2c(c1)CC(CCN1CCN(c3ccccn3)CC1)C2	10.1016/j.ejmech.2021.113243
		44324572	206770	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	319	2	2	3	4.1	Cc1c(NC2=NCCN2)cccc1-c1cccc(C(F)(F)F)c1	10.1016/s0960-894x(02)00925-3
		CHEMBL90150	206770	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	319	2	2	3	4.1	Cc1c(NC2=NCCN2)cccc1-c1cccc(C(F)(F)F)c1	10.1016/s0960-894x(02)00925-3
		162670644	182979	0	None	17	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	417	9	0	5	5.2	COc1ccc(-c2ccccc2C2CCN(CCCCOc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
		CHEMBL4793310	182979	0	None	17	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	417	9	0	5	5.2	COc1ccc(-c2ccccc2C2CCN(CCCCOc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
		156017025	177726	0	None	3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	351	2	0	1	6.1	CN(C)C1CCc2c(cccc2-c2c3ccccc3cc3ccccc23)C1	10.1016/j.bmc.2019.115262
		CHEMBL4642336	177726	0	None	3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	351	2	0	1	6.1	CN(C)C1CCc2c(cccc2-c2c3ccccc3cc3ccccc23)C1	10.1016/j.bmc.2019.115262
		11221282	57014	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	333	4	1	4	3.8	O=[N+]([O-])c1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
		CHEMBL1644274	57014	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	333	4	1	4	3.8	O=[N+]([O-])c1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
		162664163	183723	3	None	-56	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	9	1	4	4.8	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccc(C(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4782285	183723	3	None	-56	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	9	1	4	4.8	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccc(C(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4803403	183723	3	None	-56	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	9	1	4	4.8	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccc(C(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
		46204736	124575	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	5	1	3	3.4	CCOc1ccc(-c2ccccc2C)cc1OC1CNC1	nan
		CHEMBL3640581	124575	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	5	1	3	3.4	CCOc1ccc(-c2ccccc2C)cc1OC1CNC1	nan
		46204736	124575	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	5	1	3	3.4	CCOc1ccc(-c2ccccc2C)cc1OC1CNC1	nan
		CHEMBL3640581	124575	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	5	1	3	3.4	CCOc1ccc(-c2ccccc2C)cc1OC1CNC1	nan
		156013736	177263	0	None	-1	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	404	6	1	4	4.2	C#CCOc1c(OC)cc2c3c1-c1cc(NC(=O)CCC)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
		CHEMBL4636165	177263	0	None	-1	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	404	6	1	4	4.2	C#CCOc1c(OC)cc2c3c1-c1cc(NC(=O)CCC)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
		44408995	75434	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	381	8	0	5	3.3	CCOC(=O)[C@H]1CCCN(CCCC(C)(C)S(=O)(=O)c2ccccc2)C1	10.1016/j.bmcl.2005.11.067
		CHEMBL204174	75434	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	381	8	0	5	3.3	CCOC(=O)[C@H]1CCCN(CCCC(C)(C)S(=O)(=O)c2ccccc2)C1	10.1016/j.bmcl.2005.11.067
		90654858	112700	0	None	4	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	550	9	0	4	6.2	CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2014.01.065
		CHEMBL3233678	112700	0	None	4	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	550	9	0	4	6.2	CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2014.01.065
		CHEMBL3304355	112700	0	None	4	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	550	9	0	4	6.2	CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2014.01.065
		155539600	172859	0	None	-239	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	364	4	1	7	2.7	CC(Sc1ccccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
		CHEMBL4515075	172859	0	None	-239	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	364	4	1	7	2.7	CC(Sc1ccccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
		155524228	170875	0	None	-141	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	516	8	2	4	5.3	COc1ccc2[nH]cc(C3CCN(CCCCN4C(=O)CC(c5c[nH]c6ccc(F)cc56)C4=O)CC3)c2c1	10.1016/j.ejmech.2019.111736
		CHEMBL4454176	170875	0	None	-141	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	516	8	2	4	5.3	COc1ccc2[nH]cc(C3CCN(CCCCN4C(=O)CC(c5c[nH]c6ccc(F)cc56)C4=O)CC3)c2c1	10.1016/j.ejmech.2019.111736
		11761105	53641	0	None	-13	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	396	10	0	5	4.3	COc1cccc(C(=O)CCCCCN2CCN(c3ccccc3OC)CC2)c1	10.1021/jm020994z
		CHEMBL160286	53641	0	None	-13	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	396	10	0	5	4.3	COc1cccc(C(=O)CCCCCN2CCN(c3ccccc3OC)CC2)c1	10.1021/jm020994z
		71454998	81417	0	None	1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	450	9	1	4	4.5	CC(C)c1ccccc1OCCN1CCC(CNS(=O)(=O)c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159460	81417	0	None	1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	450	9	1	4	4.5	CC(C)c1ccccc1OCCN1CCC(CNS(=O)(=O)c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2012.07.043
		71574206	86268	0	None	-1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	512	7	1	5	4.7	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccc(Cl)cc2c1	10.1016/j.ejmech.2012.11.042
		CHEMBL2312641	86268	0	None	-1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	512	7	1	5	4.7	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccc(Cl)cc2c1	10.1016/j.ejmech.2012.11.042
		90654852	112636	0	None	6	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	484	9	0	4	4.5	CC1(C)C(=O)N(Cc2ccc(F)cc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.01.065
		CHEMBL3233675	112636	0	None	6	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	484	9	0	4	4.5	CC1(C)C(=O)N(Cc2ccc(F)cc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.01.065
		CHEMBL3302762	112636	0	None	6	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	484	9	0	4	4.5	CC1(C)C(=O)N(Cc2ccc(F)cc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.01.065
		155561901	175756	0	None	5	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	259	3	1	3	3.2	CCn1cncc1-c1c[nH]c2ccc(OC)c(F)c12	10.1016/j.ejmech.2019.03.017
		CHEMBL4583507	175756	0	None	5	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	259	3	1	3	3.2	CCn1cncc1-c1c[nH]c2ccc(OC)c(F)c12	10.1016/j.ejmech.2019.03.017
		71602740	89617	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccc(-c2ccccc2CN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2013.02.038
		CHEMBL2375370	89617	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccc(-c2ccccc2CN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2013.02.038
		23661734	90886	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	425	6	0	4	3.8	CC1(C)CC(=O)N(CCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)C(=O)C1	10.1016/j.bmc.2007.07.029
		CHEMBL239259	90886	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	425	6	0	4	3.8	CC1(C)CC(=O)N(CCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)C(=O)C1	10.1016/j.bmc.2007.07.029
		44439395	91810	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	296	2	3	2	3.4	Oc1c(F)cccc1CC1NCCc2c1[nH]c1ccccc21	10.1016/j.bmcl.2007.01.093
		CHEMBL241280	91810	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	296	2	3	2	3.4	Oc1c(F)cccc1CC1NCCc2c1[nH]c1ccccc21	10.1016/j.bmcl.2007.01.093
		72550641	114088	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	477	9	1	4	5.2	COc1ccccc1N1CCN(CCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1	10.1016/j.bmc.2014.07.026
		CHEMBL3326992	114088	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	477	9	1	4	5.2	COc1ccccc1N1CCN(CCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1	10.1016/j.bmc.2014.07.026
		117209857	185138	1	None	-1	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
		CHEMBL4856702	185138	1	None	-1	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
		CHEMBL5089348	215203	0	None	-23	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1ccc(C(F)(F)F)cc1	10.1021/acs.jmedchem.1c00497
		135367405	164196	0	None	2	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		CHEMBL4210782	164196	0	None	2	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		118713591	114377	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	401	6	0	5	4.3	O=c1sc2ccccc2n1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2014.08.023
		CHEMBL3331260	114377	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	401	6	0	5	4.3	O=c1sc2ccccc2n1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2014.08.023
		9862256	207120	0	None	-301	9	Human	6.3	pKi	=	6.3	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	328	5	0	4	3.0	CN(C)CCc1cccc2c1ccn2S(=O)(=O)c1ccccc1	10.1021/jm010943m
		CHEMBL92139	207120	0	None	-301	9	Human	6.3	pKi	=	6.3	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	328	5	0	4	3.0	CN(C)CCc1cccc2c1ccn2S(=O)(=O)c1ccccc1	10.1021/jm010943m
		11122723	51006	0	None	-1	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	423	9	1	7	4.1	COc1ccc2onc(N3CCN(CCCCCC(=O)c4ccccc4O)CC3)c2c1	10.1021/jm020994z
		CHEMBL157840	51006	0	None	-1	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	423	9	1	7	4.1	COc1ccc2onc(N3CCN(CCCCCC(=O)c4ccccc4O)CC3)c2c1	10.1021/jm020994z
		163409061	192189	3	None	-13	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	456	8	1	6	3.2	O=C(NCCCCCCn1nc2ccccn2c1=O)N1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2022.114319
		CHEMBL5204274	192189	3	None	-13	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	456	8	1	6	3.2	O=C(NCCCCCCn1nc2ccccn2c1=O)N1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2022.114319
		155536809	172198	0	None	3	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	412	5	0	4	3.2	O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)N1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2016.06.080
		CHEMBL4473710	172198	0	None	3	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	412	5	0	4	3.2	O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)N1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2016.06.080
		128	149	11	None	-295	8	Human	6.3	pKi	=	6.3	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cccc2O)CCC	10.1021/acs.jmedchem.7b01898
		172267	149	11	None	-295	8	Human	6.3	pKi	=	6.3	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cccc2O)CCC	10.1021/acs.jmedchem.7b01898
		CHEMBL273273	149	11	None	-295	8	Human	6.3	pKi	=	6.3	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cccc2O)CCC	10.1021/acs.jmedchem.7b01898
		1220	187	55	None	-208	44	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm030030n
		31	187	55	None	-208	44	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm030030n
		7	187	55	None	-208	44	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm030030n
		CHEMBL56	187	55	None	-208	44	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm030030n
		71062646	149543	0	None	-776	12	Mouse	6.3	pKi	=	6.3	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	338	6	0	4	2.8	c1ccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)cc1	nan
		CHEMBL3946661	149543	0	None	-776	12	Mouse	6.3	pKi	=	6.3	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	338	6	0	4	2.8	c1ccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)cc1	nan
		122181337	121879	0	None	-21	3	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	462	7	1	5	3.4	COc1ccccc1N1CCN(CCCCN2C(=O)NC3(CCCc4ccccc43)C2=O)CC1	10.1016/j.bmc.2015.04.026
		CHEMBL3590089	121879	0	None	-21	3	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	462	7	1	5	3.4	COc1ccccc1N1CCN(CCCCN2C(=O)NC3(CCCc4ccccc43)C2=O)CC1	10.1016/j.bmc.2015.04.026
		127028471	138181	0	None	8	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	460	6	2	5	2.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3Cl)CC2)C1=O	10.1016/j.ejmech.2016.02.024
		CHEMBL3769606	138181	0	None	8	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	460	6	2	5	2.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3Cl)CC2)C1=O	10.1016/j.ejmech.2016.02.024
		117209857	185138	1	None	-1	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
		CHEMBL4856702	185138	1	None	-1	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
		57325521	71570	0	None	1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
		CHEMBL1949977	71570	0	None	1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
		CHEMBL1963103	71570	0	None	1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
		24854106	161061	1	None	-2	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	367	6	1	3	3.9	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm200547z
		CHEMBL411663	161061	1	None	-2	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	367	6	1	3	3.9	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm200547z
		135367405	164196	0	None	2	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		CHEMBL4210782	164196	0	None	2	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		42625445	186778	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	399	6	0	3	4.3	O=C1Cc2ccccc2N1CCCCN1CCN(c2cccc3ccccc23)CC1	10.1021/jm8014553
		CHEMBL489028	186778	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	399	6	0	3	4.3	O=C1Cc2ccccc2N1CCCCN1CCN(c2cccc3ccccc23)CC1	10.1021/jm8014553
		162662892	181914	0	None	20	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	468	9	0	4	6.1	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc(Cl)cc3F)CC2)cc1	10.1016/j.ejmech.2020.112395
		CHEMBL4779459	181914	0	None	20	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	468	9	0	4	6.1	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc(Cl)cc3F)CC2)cc1	10.1016/j.ejmech.2020.112395
		135398737	958	93	None	-13	89	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.03.017
		38	958	93	None	-13	89	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.03.017
		722	958	93	None	-13	89	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.03.017
		CHEMBL42	958	93	None	-13	89	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.03.017
		DB00363	958	93	None	-13	89	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.03.017
		72548117	114086	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	471	10	1	4	5.3	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2cccc(C)c2)CC1	10.1016/j.bmc.2014.07.026
		CHEMBL3326990	114086	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	471	10	1	4	5.3	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2cccc(C)c2)CC1	10.1016/j.bmc.2014.07.026
		135398737	958	93	None	-13	89	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.001
		38	958	93	None	-13	89	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.001
		722	958	93	None	-13	89	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.001
		CHEMBL42	958	93	None	-13	89	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.001
		DB00363	958	93	None	-13	89	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.001
		CHEMBL5093250	215420	0	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1ccc(F)c(F)c1	10.1021/acs.jmedchem.1c00497
		46205368	124582	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	291	3	1	2	3.8	Cc1cc(-c2ccc(Cl)cc2OC2CNC2)ccc1F	nan
		CHEMBL3640588	124582	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	291	3	1	2	3.8	Cc1cc(-c2ccc(Cl)cc2OC2CNC2)ccc1F	nan
		46205368	124582	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	291	3	1	2	3.8	Cc1cc(-c2ccc(Cl)cc2OC2CNC2)ccc1F	nan
		CHEMBL3640588	124582	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	291	3	1	2	3.8	Cc1cc(-c2ccc(Cl)cc2OC2CNC2)ccc1F	nan
		162666903	183734	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	369	7	2	5	2.9	COc1ccccc1N1CCN(CCCC(=O)Nc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4787550	183734	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	369	7	2	5	2.9	COc1ccccc1N1CCN(CCCC(=O)Nc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4803553	183734	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	369	7	2	5	2.9	COc1ccccc1N1CCN(CCCC(=O)Nc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
		2133793	21817	13	None	1	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	476	5	2	5	6.2	O=S(=O)(Nc1cc(Sc2cccc3cccnc23)c(O)c2ccccc12)c1ccc(F)cc1	10.1016/j.bmcl.2015.03.049
		CHEMBL1319488	21817	13	None	1	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	476	5	2	5	6.2	O=S(=O)(Nc1cc(Sc2cccc3cccnc23)c(O)c2ccccc12)c1ccc(F)cc1	10.1016/j.bmcl.2015.03.049
		3649661	138219	7	None	-64	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	329	3	3	7	2.2	CCOC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
		CHEMBL3770106	138219	7	None	-64	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	329	3	3	7	2.2	CCOC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
		76518514	113537	0	None	-50	9	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	387	6	1	2	5.3	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
		CHEMBL3321788	113537	0	None	-50	9	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	387	6	1	2	5.3	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
		118736395	118949	0	None	-234	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	493	7	1	11	0.7	Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccccc5O)CC4)c(=O)ccn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
		CHEMBL3423377	118949	0	None	-234	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	493	7	1	11	0.7	Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccccc5O)CC4)c(=O)ccn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
		168287240	191737	0	None	1	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	457	9	4	7	4.4	Nc1nc(NCCOc2cccc(Cl)c2Cl)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
		CHEMBL5197266	191737	0	None	1	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	457	9	4	7	4.4	Nc1nc(NCCOc2cccc(Cl)c2Cl)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
		155534301	171935	0	None	-11	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	415	8	0	5	4.0	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ncccn2)CC1	10.1016/j.bmcl.2019.06.029
		CHEMBL4470304	171935	0	None	-11	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	415	8	0	5	4.0	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ncccn2)CC1	10.1016/j.bmcl.2019.06.029
		90654678	110099	0	None	-6	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	450	8	2	5	2.5	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2O)CC1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235750	110099	0	None	-6	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	450	8	2	5	2.5	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2O)CC1	10.1016/j.ejmech.2014.03.005
		44424652	85924	0	None	2	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	426	7	0	9	1.0	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2007.05.017
		CHEMBL229940	85924	0	None	2	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	426	7	0	9	1.0	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2007.05.017
		90654699	110085	0	None	-12	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	406	8	1	4	2.5	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235736	110085	0	None	-12	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	406	8	1	4	2.5	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2014.03.005
		52952309	62590	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	427	7	1	6	4.8	O=C(CCNC1CCN(c2ccc([N+](=O)[O-])cc2)CC1)c1csc2ccc(F)cc12	10.1021/jm2000773
		CHEMBL1782807	62590	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	427	7	1	6	4.8	O=C(CCNC1CCN(c2ccc([N+](=O)[O-])cc2)CC1)c1csc2ccc(F)cc12	10.1021/jm2000773
		13069602	120612	0	None	-478	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	430	6	0	8	1.7	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		CHEMBL3360996	120612	0	None	-478	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	430	6	0	8	1.7	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		CHEMBL3546112	120612	0	None	-478	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	430	6	0	8	1.7	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		76310811	106277	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	395	5	0	3	5.5	CCc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
		CHEMBL3121417	106277	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	395	5	0	3	5.5	CCc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
		CHEMBL3139021	106277	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	395	5	0	3	5.5	CCc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
		6603866	97429	17	None	-95	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1	10.1016/j.bmc.2019.115262
		CHEMBL26998	97429	17	None	-95	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1	10.1016/j.bmc.2019.115262
		CHEMBL541268	97429	17	None	-95	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1	10.1016/j.bmc.2019.115262
		135398737	958	93	None	-13	89	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
		38	958	93	None	-13	89	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
		722	958	93	None	-13	89	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
		CHEMBL42	958	93	None	-13	89	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
		DB00363	958	93	None	-13	89	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
		23369455	181475	2	None	1	2	Human	7.3	pKi	=	7.3	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	350	6	1	4	2.9	O=c1[nH]c2ccccc2n1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2009.02.008
		CHEMBL476462	181475	2	None	1	2	Human	7.3	pKi	=	7.3	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	350	6	1	4	2.9	O=c1[nH]c2ccccc2n1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2009.02.008
		135398737	958	93	None	-13	89	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.001
		38	958	93	None	-13	89	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.001
		722	958	93	None	-13	89	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.001
		CHEMBL42	958	93	None	-13	89	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.001
		DB00363	958	93	None	-13	89	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.001
		11248332	84310	0	None	-2	3	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	430	8	1	4	4.4	N#Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
		CHEMBL221513	84310	0	None	-2	3	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	430	8	1	4	4.4	N#Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
		127036953	137515	0	None	-4	22	Human	7.3	pKi	=	7.3	Binding	Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay	ChEMBL	318	7	1	1	4.1	C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12	10.1016/j.bmcl.2015.12.053
		CHEMBL3754166	137515	0	None	-4	22	Human	7.3	pKi	=	7.3	Binding	Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay	ChEMBL	318	7	1	1	4.1	C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12	10.1016/j.bmcl.2015.12.053
		117209971	186485	1	None	2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4877051	186485	1	None	2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL5076846	214464	0	None	-75	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		C[C@H]1C[C@H](NS(=O)(=O)c2cc3ccc(F)cc3s2)CN1CCCc1noc2cc(F)ccc12	10.1021/acs.jmedchem.1c00497
		9926401	140875	0	None	2	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3819556	140875	0	None	2	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3819732	140875	0	None	2	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		53377239	66390	0	None	-15	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	443	7	0	7	3.6	COc1cccc(N2CCN(CCCCn3cnc4c(cnc5ccccc54)c3=O)CC2)c1	10.1016/j.ejmech.2011.04.060
		CHEMBL1851772	66390	0	None	-15	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	443	7	0	7	3.6	COc1cccc(N2CCN(CCCCn3cnc4c(cnc5ccccc54)c3=O)CC2)c1	10.1016/j.ejmech.2011.04.060
		CHEMBL3217162	66390	0	None	-15	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	443	7	0	7	3.6	COc1cccc(N2CCN(CCCCn3cnc4c(cnc5ccccc54)c3=O)CC2)c1	10.1016/j.ejmech.2011.04.060
		155514217	169832	0	None	-17	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	461	8	0	5	3.9	O=C1c2ccccc2S(=O)(=O)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2021.128028
		CHEMBL4439795	169832	0	None	-17	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	461	8	0	5	3.9	O=C1c2ccccc2S(=O)(=O)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2021.128028
		155551685	175132	0	None	-4	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	495	8	0	5	4.5	O=C1c2ccccc2S(=O)(=O)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2021.128028
		CHEMBL4569757	175132	0	None	-4	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	495	8	0	5	4.5	O=C1c2ccccc2S(=O)(=O)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2021.128028
		164618482	185915	0	None	-13	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	6	1	7	2.5	CN1CCN(c2nc(N)nc(CCCOc3ccc(Cl)c(Cl)c3)n2)CC1	10.1016/j.ejmech.2020.112529
		CHEMBL4868911	185915	0	None	-13	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	6	1	7	2.5	CN1CCN(c2nc(N)nc(CCCOc3ccc(Cl)c(Cl)c3)n2)CC1	10.1016/j.ejmech.2020.112529
		155552799	176305	0	None	-91	5	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.2	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4545270	176305	0	None	-91	5	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.2	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4595236	176305	0	None	-91	5	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.2	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1	10.1016/j.bmc.2019.06.028
		9878197	196178	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	250	4	4	3	1.0	CCOc1ccccc1CNC(=N)NC(=O)NC	10.1016/j.bmcl.2009.06.038
		CHEMBL561346	196178	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	250	4	4	3	1.0	CCOc1ccccc1CNC(=N)NC(=O)NC	10.1016/j.bmcl.2009.06.038
		127037921	137031	0	None	4	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	474	9	0	6	3.7	Cn1cc(S(=O)(=O)N(CC2CC2)C2CCN(CCOc3ccccc3C(C)(C)C)CC2)cn1	10.1016/j.bmc.2015.11.041
		CHEMBL3746493	137031	0	None	4	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	474	9	0	6	3.7	Cn1cc(S(=O)(=O)N(CC2CC2)C2CCN(CCOc3ccccc3C(C)(C)C)CC2)cn1	10.1016/j.bmc.2015.11.041
		155512944	169719	0	None	11	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	249	1	1	2	3.4	Cn1cncc1-c1c[nH]c2ccc(Cl)c(F)c12	10.1016/j.ejmech.2019.03.017
		CHEMBL4438349	169719	0	None	11	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	249	1	1	2	3.4	Cn1cncc1-c1c[nH]c2ccc(Cl)c(F)c12	10.1016/j.ejmech.2019.03.017
		127038035	136717	0	None	5	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	436	8	1	4	4.2	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccccc1	10.1039/C5MD00166H
		CHEMBL3740691	136717	0	None	5	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	436	8	1	4	4.2	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccccc1	10.1039/C5MD00166H
		117209971	186485	1	None	2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4877051	186485	1	None	2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		9926401	140875	0	None	2	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3819556	140875	0	None	2	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3819732	140875	0	None	2	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		24768517	92828	0	None	2	3	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	447	10	1	3	5.5	CCCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
		CHEMBL243742	92828	0	None	2	3	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	447	10	1	3	5.5	CCCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
		57397588	71479	0	None	-24	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	375	7	1	5	2.4	O=C1C2CCSN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
		CHEMBL1926747	71479	0	None	-24	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	375	7	1	5	2.4	O=C1C2CCSN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
		CHEMBL1962460	71479	0	None	-24	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	375	7	1	5	2.4	O=C1C2CCSN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
		90654691	110077	0	None	-21	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	432	10	1	5	3.0	CSc1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235728	110077	0	None	-21	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	432	10	1	5	3.0	CSc1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
		162673808	183774	0	None	-23	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	8	1	4	4.9	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4795248	183774	0	None	-23	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	8	1	4	4.9	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4803963	183774	0	None	-23	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	8	1	4	4.9	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
		11421045	136941	0	None	1	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	447	9	1	4	4.8	CC(=O)c1cccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)c1	10.1021/jm049702f
		CHEMBL374298	136941	0	None	1	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	447	9	1	4	4.8	CC(=O)c1cccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)c1	10.1021/jm049702f
		134133633	154592	0	None	-3	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	407	5	0	1	6.9	Clc1ccc(C(=CCCN2CCc3ccccc3C2)c2ccc(Cl)cc2)cc1	10.1016/j.bmc.2016.09.019
		CHEMBL3899822	154592	0	None	-3	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	407	5	0	1	6.9	Clc1ccc(C(=CCCN2CCc3ccccc3C2)c2ccc(Cl)cc2)cc1	10.1016/j.bmc.2016.09.019
		CHEMBL3991400	154592	0	None	-3	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	407	5	0	1	6.9	Clc1ccc(C(=CCCN2CCc3ccccc3C2)c2ccc(Cl)cc2)cc1	10.1016/j.bmc.2016.09.019
		44582678	181574	0	None	-3	10	Human	6.3	pKi	=	6.3	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	401	9	1	4	4.3	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL476839	181574	0	None	-3	10	Human	6.3	pKi	=	6.3	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	401	9	1	4	4.3	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
		44393088	65013	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	386	8	3	7	3.4	CC(Nc1nc(N)nc(NCCOc2ccc(F)cc2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
		CHEMBL182322	65013	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	386	8	3	7	3.4	CC(Nc1nc(N)nc(NCCOc2ccc(F)cc2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
		44393170	65235	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	336	7	2	4	4.4	C[C@H](Nc1cc(NCCc2ccc(F)cc2)ncn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		CHEMBL182680	65235	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	336	7	2	4	4.4	C[C@H](Nc1cc(NCCc2ccc(F)cc2)ncn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		44393171	65389	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	352	8	2	5	4.3	C[C@H](Nc1cc(NCCOc2ccc(F)cc2)ncn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		CHEMBL182943	65389	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	352	8	2	5	4.3	C[C@H](Nc1cc(NCCOc2ccc(F)cc2)ncn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		10785714	20228	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	375	5	1	3	3.8	O=C1Nc2cccc3c2C1(CCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm030030n
		CHEMBL13052	20228	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	375	5	1	3	3.8	O=C1Nc2cccc3c2C1(CCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm030030n
		127042184	136982	0	None	6	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	468	8	0	4	4.7	CN(C1CCN(CCOc2ccccc2-c2ccccc2)CC1)S(=O)(=O)c1ccc(F)cc1	10.1016/j.bmc.2015.11.041
		CHEMBL3745815	136982	0	None	6	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	468	8	0	4	4.7	CN(C1CCN(CCOc2ccccc2-c2ccccc2)CC1)S(=O)(=O)c1ccc(F)cc1	10.1016/j.bmc.2015.11.041
		2865	4143	73	None	-12	53	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.ejmech.2018.01.002
		59	4143	73	None	-12	53	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.ejmech.2018.01.002
		60854	4143	73	None	-12	53	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.ejmech.2018.01.002
		CHEMBL708	4143	73	None	-12	53	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.ejmech.2018.01.002
		DB00246	4143	73	None	-12	53	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.ejmech.2018.01.002
		71458625	81375	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	432	8	1	6	3.6	CSc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(Cl)s2)C1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159322	81375	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	432	8	1	6	3.6	CSc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(Cl)s2)C1	10.1016/j.ejmech.2012.07.043
		71458626	81376	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	440	8	1	4	3.9	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159323	81376	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	440	8	1	4	3.9	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
		118731356	118192	0	None	1	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	502	8	0	4	4.6	O=C([C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
		CHEMBL3409039	118192	0	None	1	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	502	8	0	4	4.6	O=C([C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
		138691364	171907	2	None	24	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	254	3	2	3	2.2	CCn1cncc1-c1c[nH]c2ccc(C(N)=O)cc12	10.1016/j.ejmech.2019.03.017
		CHEMBL4469847	171907	2	None	24	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	254	3	2	3	2.2	CCn1cncc1-c1c[nH]c2ccc(C(N)=O)cc12	10.1016/j.ejmech.2019.03.017
		138691364	171907	2	None	24	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	254	3	2	3	2.2	CCn1cncc1-c1c[nH]c2ccc(C(N)=O)cc12	10.1039/C8MD00313K
		CHEMBL4469847	171907	2	None	24	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	254	3	2	3	2.2	CCn1cncc1-c1c[nH]c2ccc(C(N)=O)cc12	10.1039/C8MD00313K
		145982165	166604	0	None	51	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	488	7	2	6	2.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3cccc4ccccc34)C2=O)CC1	10.1039/C8MD00168E
		CHEMBL4280511	166604	0	None	51	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	488	7	2	6	2.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3cccc4ccccc34)C2=O)CC1	10.1039/C8MD00168E
		137651887	157299	0	None	-1	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	443	7	2	3	4.6	Cc1cccc(S(=O)(=O)NCCCN2CC=C(c3c[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
		CHEMBL4077040	157299	0	None	-1	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	443	7	2	3	4.6	Cc1cccc(S(=O)(=O)NCCCN2CC=C(c3c[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
		9845006	18239	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL12702	18239	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1016/j.bmc.2019.06.028
		11646336	65996	1	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	367	6	1	3	3.9	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccc(F)cc2)CC1	10.1021/jm200547z
		CHEMBL1836785	65996	1	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	367	6	1	3	3.9	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccc(F)cc2)CC1	10.1021/jm200547z
		44372581	119819	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	420	6	1	2	5.8	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccccc2)CC1)CCC3	10.1016/s0960-894x(02)00842-9
		CHEMBL348410	119819	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	420	6	1	2	5.8	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccccc2)CC1)CCC3	10.1016/s0960-894x(02)00842-9
		9845006	18239	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1016/s0960-894x(00)00166-9
		CHEMBL12702	18239	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1016/s0960-894x(00)00166-9
		10785714	20228	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	375	5	1	3	3.8	O=C1Nc2cccc3c2C1(CCCN1CCN(c2ccccc2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
		CHEMBL13052	20228	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	375	5	1	3	3.8	O=C1Nc2cccc3c2C1(CCCN1CCN(c2ccccc2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
		9845006	18239	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm030841r
		CHEMBL12702	18239	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm030841r
		10785714	20228	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	375	5	1	3	3.8	O=C1Nc2cccc3c2C1(CCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm030841r
		CHEMBL13052	20228	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	375	5	1	3	3.8	O=C1Nc2cccc3c2C1(CCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm030841r
		162659494	181354	0	None	-15	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	435	7	1	5	4.0	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2ccccc2c1	10.1016/j.ejmech.2020.112149
		CHEMBL4763085	181354	0	None	-15	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	435	7	1	5	4.0	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2ccccc2c1	10.1016/j.ejmech.2020.112149
		162674158	183003	0	None	-12	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	441	7	1	6	4.0	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1csc2ccccc12	10.1016/j.ejmech.2020.112149
		CHEMBL4793608	183003	0	None	-12	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	441	7	1	6	4.0	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1csc2ccccc12	10.1016/j.ejmech.2020.112149
		107	141	121	None	-3	30	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1016/j.ejmech.2019.111705
		1833	141	121	None	-3	30	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1016/j.ejmech.2019.111705
		CHEMBL8165	141	121	None	-3	30	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1016/j.ejmech.2019.111705
		2865	4143	73	None	-12	53	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
		59	4143	73	None	-12	53	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
		60854	4143	73	None	-12	53	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
		CHEMBL708	4143	73	None	-12	53	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
		DB00246	4143	73	None	-12	53	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
		11536843	115123	0	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		CHEMBL3343673	115123	0	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
		54758293	65997	0	None	7	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	445	7	1	3	5.3	CCC1(CCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
		CHEMBL1836786	65997	0	None	7	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	445	7	1	3	5.3	CCC1(CCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
		56944186	112090	0	None	2	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	504	8	1	7	4.6	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
		CHEMBL3289984	112090	0	None	2	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	504	8	1	7	4.6	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
		56944190	112100	0	None	-1	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	499	8	1	5	5.2	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
		CHEMBL3289994	112100	0	None	-1	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	499	8	1	5	5.2	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
		25107578	193056	0	None	4	3	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	408	10	1	4	4.2	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	10.1021/jm800615e
		CHEMBL522343	193056	0	None	4	3	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	408	10	1	4	4.2	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	10.1021/jm800615e
		24854370	157070	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3ccccc3Cl)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		CHEMBL407412	157070	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3ccccc3Cl)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		9845006	18239	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
		CHEMBL12702	18239	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
		9845006	18239	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm980519u
		CHEMBL12702	18239	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm980519u
		118713680	114385	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	411	8	0	6	4.1	COc1ccccc1N1CCN(CCCCCn2c(=O)sc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
		CHEMBL3331383	114385	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	411	8	0	6	4.1	COc1ccccc1N1CCN(CCCCCn2c(=O)sc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
		92042876	151336	0	None	2	10	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		CHEMBL3961059	151336	0	None	2	10	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		10402615	202517	0	None	-20	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	301	2	0	1	4.9	CN(C)[C@H]1CCc2c(cccc2-c2cccc3ccccc23)C1	10.1016/j.bmc.2019.115262
		CHEMBL611472	202517	0	None	-20	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	301	2	0	1	4.9	CN(C)[C@H]1CCc2c(cccc2-c2cccc3ccccc23)C1	10.1016/j.bmc.2019.115262
		92042876	151336	0	None	2	10	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
		CHEMBL3961059	151336	0	None	2	10	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
		10785714	20228	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	375	5	1	3	3.8	O=C1Nc2cccc3c2C1(CCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm980519u
		CHEMBL13052	20228	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	375	5	1	3	3.8	O=C1Nc2cccc3c2C1(CCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm980519u
		92042876	151336	0	None	2	10	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		CHEMBL3961059	151336	0	None	2	10	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		71457985	78537	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	313	4	0	4	3.2	COc1cccc(OC)c1-c1cccc2c1OC[C@@H](N(C)C)C2	10.1016/j.bmcl.2004.11.013
		CHEMBL2112053	78537	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	313	4	0	4	3.2	COc1cccc(OC)c1-c1cccc2c1OC[C@@H](N(C)C)C2	10.1016/j.bmcl.2004.11.013
		11153905	65606	0	None	-2	2	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	313	4	0	4	3.2	COc1cccc(OC)c1-c1cccc2c1OC[C@H](N(C)C)C2	10.1021/jm0498102
		CHEMBL183329	65606	0	None	-2	2	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	313	4	0	4	3.2	COc1cccc(OC)c1-c1cccc2c1OC[C@H](N(C)C)C2	10.1021/jm0498102
		156013466	177509	0	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	269	2	0	1	3.9	CN(C)[C@H]1CCc2c(cccc2-c2ccccc2F)C1	10.1016/j.bmc.2019.115262
		CHEMBL4639638	177509	0	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	269	2	0	1	3.9	CN(C)[C@H]1CCc2c(cccc2-c2ccccc2F)C1	10.1016/j.bmc.2019.115262
		156013520	177511	0	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	325	6	0	1	5.5	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2F)C1	10.1016/j.bmc.2019.115262
		CHEMBL4639661	177511	0	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	325	6	0	1	5.5	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2F)C1	10.1016/j.bmc.2019.115262
		66801140	111662	0	None	2	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	482	8	1	6	4.0	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
		CHEMBL3286432	111662	0	None	2	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	482	8	1	6	4.0	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
		24854039	95767	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	394	7	1	2	5.5	CCC1(CCCCN2CCC(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		CHEMBL258537	95767	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	394	7	1	2	5.5	CCC1(CCCCN2CCC(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		11603891	96915	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	407	8	1	4	4.3	CCC1(CCCCN2CCN(c3ccccc3OC)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		CHEMBL265927	96915	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	407	8	1	4	4.3	CCC1(CCCCN2CCN(c3ccccc3OC)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
		11617668	64696	0	None	3	3	Human	8.3	pKi	=	8.3	Binding	Binding affinity against Human 5-HT7R expressed in sf9 cellsBinding affinity against Human 5-HT7R expressed in sf9 cells	ChEMBL	372	5	0	5	3.7	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C#N)c2)CC1	10.1016/j.bmcl.2005.05.059
		CHEMBL181874	64696	0	None	3	3	Human	8.3	pKi	=	8.3	Binding	Binding affinity against Human 5-HT7R expressed in sf9 cellsBinding affinity against Human 5-HT7R expressed in sf9 cells	ChEMBL	372	5	0	5	3.7	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C#N)c2)CC1	10.1016/j.bmcl.2005.05.059
		11603891	96915	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	407	8	1	4	4.3	CCC1(CCCCN2CCN(c3ccccc3OC)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
		CHEMBL265927	96915	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	407	8	1	4	4.3	CCC1(CCCCN2CCN(c3ccccc3OC)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
		11617668	64696	0	None	3	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	372	5	0	5	3.7	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C#N)c2)CC1	10.1016/j.bmcl.2007.03.054
		CHEMBL181874	64696	0	None	3	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	372	5	0	5	3.7	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C#N)c2)CC1	10.1016/j.bmcl.2007.03.054
		46205370	124584	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	267	3	1	2	3.7	COc1ccc(-c2ccccc2C)cc1C1CCNC1	nan
		CHEMBL3640590	124584	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	267	3	1	2	3.7	COc1ccc(-c2ccccc2C)cc1C1CCNC1	nan
		46205370	124584	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	267	3	1	2	3.7	COc1ccc(-c2ccccc2C)cc1C1CCNC1	nan
		CHEMBL3640590	124584	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	267	3	1	2	3.7	COc1ccc(-c2ccccc2C)cc1C1CCNC1	nan
		162650362	180013	0	None	-27	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	435	7	1	5	4.0	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2ccccc2c1	10.1016/j.ejmech.2020.112149
		CHEMBL4747225	180013	0	None	-27	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	435	7	1	5	4.0	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2ccccc2c1	10.1016/j.ejmech.2020.112149
		135398737	958	93	None	-13	89	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.12.024
		38	958	93	None	-13	89	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.12.024
		722	958	93	None	-13	89	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.12.024
		CHEMBL42	958	93	None	-13	89	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.12.024
		DB00363	958	93	None	-13	89	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.12.024
		10706553	97696	0	None	5	5	Rat	8.3	pKi	=	8.3	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	261	0	0	1	3.9	C[C@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
		CHEMBL27132	97696	0	None	5	5	Rat	8.3	pKi	=	8.3	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	261	0	0	1	3.9	C[C@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
		101747513	173322	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constant	ChEMBL	277	4	0	5	3.2	CN(C)CCSc1nc2ccsc2n2cccc12	10.1016/j.ejmech.2019.111690
		CHEMBL4526441	173322	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constant	ChEMBL	277	4	0	5	3.2	CN(C)CCSc1nc2ccsc2n2cccc12	10.1016/j.ejmech.2019.111690
		154926523	190291	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Binding affinity to rat 5-HT7 receptor assessed as inhibition constantBinding affinity to rat 5-HT7 receptor assessed as inhibition constant	ChEMBL	425	9	1	4	4.2	CC1(CCCCN2CCN(c3cccc(OCCF)c3)CC2)C(=O)Nc2ccccc21	10.1021/acs.jmedchem.2c00633
		CHEMBL5175774	190291	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Binding affinity to rat 5-HT7 receptor assessed as inhibition constantBinding affinity to rat 5-HT7 receptor assessed as inhibition constant	ChEMBL	425	9	1	4	4.2	CC1(CCCCN2CCN(c3cccc(OCCF)c3)CC2)C(=O)Nc2ccccc21	10.1021/acs.jmedchem.2c00633
		11976	920	59	None	-5	24	Rat	8.3	pKi	=	8.3	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1021/jm030030n
		667467	920	59	None	-5	24	Rat	8.3	pKi	=	8.3	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1021/jm030030n
		CHEMBL908	920	59	None	-5	24	Rat	8.3	pKi	=	8.3	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1021/jm030030n
		DB01239	920	59	None	-5	24	Rat	8.3	pKi	=	8.3	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1021/jm030030n
		23661594	90625	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	664	16	0	8	6.3	COc1ccccc1N1CCN(CCc2cccc(OCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		CHEMBL238808	90625	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	664	16	0	8	6.3	COc1ccccc1N1CCN(CCc2cccc(OCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		25107718	187538	0	None	18	3	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	535	12	1	6	4.7	CS(=O)(=O)Oc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1	10.1021/jm800615e
		CHEMBL494458	187538	0	None	18	3	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	535	12	1	6	4.7	CS(=O)(=O)Oc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1	10.1021/jm800615e
		9887186	204297	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	399	5	2	2	4.9	O=C1Nc2cccc3c2C1(CCCCN1CCc2c([nH]c4ccccc24)C1)CCC3	10.1021/jm0104264
		CHEMBL71383	204297	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	399	5	2	2	4.9	O=C1Nc2cccc3c2C1(CCCCN1CCc2c([nH]c4ccccc24)C1)CCC3	10.1021/jm0104264
		10948963	49015	0	None	-1	2	Rat	8.2	pKi	=	8.2	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	382	9	1	5	4.0	COc1ccccc1N1CCN(CCCCCC(=O)c2ccccc2O)CC1	10.1021/jm020994z
		CHEMBL156089	49015	0	None	-1	2	Rat	8.2	pKi	=	8.2	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	382	9	1	5	4.0	COc1ccccc1N1CCN(CCCCCC(=O)c2ccccc2O)CC1	10.1021/jm020994z
		135398737	958	93	None	-13	89	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.12.024
		38	958	93	None	-13	89	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.12.024
		722	958	93	None	-13	89	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.12.024
		CHEMBL42	958	93	None	-13	89	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.12.024
		DB00363	958	93	None	-13	89	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.12.024
		156011291	177376	0	None	-9	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	341	6	0	1	6.0	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2Cl)C1	10.1016/j.bmc.2019.115262
		CHEMBL4637900	177376	0	None	-9	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	341	6	0	1	6.0	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2Cl)C1	10.1016/j.bmc.2019.115262
		118713679	114384	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	395	8	0	6	3.6	COc1ccccc1N1CCN(CCCCCn2c(=O)oc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
		CHEMBL3331382	114384	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	395	8	0	6	3.6	COc1ccccc1N1CCN(CCCCCn2c(=O)oc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
		56944189	112093	0	None	2	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	454	8	1	8	2.4	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cnc2ccccn12	10.1021/jm401895u
		CHEMBL3289987	112093	0	None	2	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	454	8	1	8	2.4	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cnc2ccccn12	10.1021/jm401895u
		24854272	96199	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c(Cl)cc(F)cc21	10.1021/jm070279v
		CHEMBL260761	96199	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c(Cl)cc(F)cc21	10.1021/jm070279v
		46204081	124550	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	285	5	1	4	2.7	COc1ccc(-c2ccccc2OC)cc1OC1CNC1	nan
		CHEMBL3640558	124550	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	285	5	1	4	2.7	COc1ccc(-c2ccccc2OC)cc1OC1CNC1	nan
		46204081	124550	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	285	5	1	4	2.7	COc1ccc(-c2ccccc2OC)cc1OC1CNC1	nan
		CHEMBL3640558	124550	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	285	5	1	4	2.7	COc1ccc(-c2ccccc2OC)cc1OC1CNC1	nan
		90654704	110090	0	None	4	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	413	8	1	6	2.0	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235741	110090	0	None	4	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	413	8	1	6	2.0	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
		127026141	137664	0	None	19	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	466	8	1	6	3.4	Cn1cc(S(=O)(=O)NC2CC3CCC(C2)N3CCOc2cccc(-c3ccccc3)c2)cn1	10.1016/j.ejmech.2015.11.040
		CHEMBL3758488	137664	0	None	19	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	466	8	1	6	3.4	Cn1cc(S(=O)(=O)NC2CC3CCC(C2)N3CCOc2cccc(-c3ccccc3)c2)cn1	10.1016/j.ejmech.2015.11.040
		155562997	175237	0	None	-3	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	486	7	2	3	5.3	O=C1CC(c2c[nH]c3ccc(F)cc23)C(=O)N1CCCCN1CCC(c2c[nH]c3ccccc23)CC1	10.1016/j.ejmech.2019.111736
		CHEMBL4571862	175237	0	None	-3	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	486	7	2	3	5.3	O=C1CC(c2c[nH]c3ccc(F)cc23)C(=O)N1CCCCN1CCC(c2c[nH]c3ccccc23)CC1	10.1016/j.ejmech.2019.111736
		145946840	167586	0	None	3	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	452	7	2	6	2.0	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(C)cc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
		CHEMBL4176588	167586	0	None	3	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	452	7	2	6	2.0	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(C)cc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
		CHEMBL4300745	167586	0	None	3	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	452	7	2	6	2.0	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(C)cc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
		57394663	71555	0	None	2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	457	8	1	4	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2011.12.039
		CHEMBL1949973	71555	0	None	2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	457	8	1	4	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2011.12.039
		CHEMBL1963031	71555	0	None	2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	457	8	1	4	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2011.12.039
		118706294	120535	0	None	-7	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	311	3	3	3	1.3	COCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
		CHEMBL3310118	120535	0	None	-7	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	311	3	3	3	1.3	COCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
		CHEMBL3545470	120535	0	None	-7	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	311	3	3	3	1.3	COCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
		122178708	121374	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	423	5	0	5	5.2	COc1cc2c(cc1OC1CCCCC1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
		CHEMBL3581253	121374	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	423	5	0	5	5.2	COc1cc2c(cc1OC1CCCCC1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
		53248365	62086	0	None	-52	7	Human	7.3	pKi	=	7.3	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	554	6	1	5	2.9	O=C(N(CCN1CCN(c2ccccc2O)CC1)c1ccccn1)C12C3C4C1C1C2C3C41I	10.1021/jm1009956
		CHEMBL1774995	62086	0	None	-52	7	Human	7.3	pKi	=	7.3	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	554	6	1	5	2.9	O=C(N(CCN1CCN(c2ccccc2O)CC1)c1ccccn1)C12C3C4C1C1C2C3C41I	10.1021/jm1009956
		277	1301	62	None	-43	50	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1016/s0960-894x(00)00166-9
		2913	1301	62	None	-43	50	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1016/s0960-894x(00)00166-9
		765	1301	62	None	-43	50	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1016/s0960-894x(00)00166-9
		CHEMBL516	1301	62	None	-43	50	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1016/s0960-894x(00)00166-9
		DB00434	1301	62	None	-43	50	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1016/s0960-894x(00)00166-9
		8431	1484	9	None	-22	5	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm030841r
		9843179	1484	9	None	-22	5	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm030841r
		CHEMBL69257	1484	9	None	-22	5	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm030841r
		277	1301	62	None	-63	50	Human	7.3	pKi	=	7.3	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1021/jm030841r
		2913	1301	62	None	-63	50	Human	7.3	pKi	=	7.3	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1021/jm030841r
		765	1301	62	None	-63	50	Human	7.3	pKi	=	7.3	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1021/jm030841r
		CHEMBL516	1301	62	None	-63	50	Human	7.3	pKi	=	7.3	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1021/jm030841r
		DB00434	1301	62	None	-63	50	Human	7.3	pKi	=	7.3	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1021/jm030841r
		155549018	174242	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	426	6	0	4	3.2	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ccccc2Cl)CC1	10.1016/j.bmcl.2016.06.080
		CHEMBL4548926	174242	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	426	6	0	4	3.2	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ccccc2Cl)CC1	10.1016/j.bmcl.2016.06.080
		191	403	98	None	-41	29	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1021/jm030030n
		201	403	98	None	-41	29	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1021/jm030030n
		2170	403	98	None	-41	29	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1021/jm030030n
		CHEMBL1113	403	98	None	-41	29	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1021/jm030030n
		DB00543	403	98	None	-41	29	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1021/jm030030n
		44439399	147392	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	422	5	0	5	4.8	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(OC(C)=O)CCCC3)CC2	10.1016/j.bmcl.2007.01.093
		CHEMBL392970	147392	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	422	5	0	5	4.8	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(OC(C)=O)CCCC3)CC2	10.1016/j.bmcl.2007.01.093
		59752538	181152	0	None	-251	4	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	339	3	1	4	3.7	CC(C)n1nc2c(c1-c1ccc(OC(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
		CHEMBL4760784	181152	0	None	-251	4	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	339	3	1	4	3.7	CC(C)n1nc2c(c1-c1ccc(OC(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
		156308	169283	5	None	-2	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	354	2	0	4	3.2	COc1ccc2c(c1OC)C[N+]1(C)CCc3cc4c(cc3C1C2)OCO4	10.1016/j.bmcl.2007.01.093
		CHEMBL441356	169283	5	None	-2	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	354	2	0	4	3.2	COc1ccc2c(c1OC)C[N+]1(C)CCc3cc4c(cc3C1C2)OCO4	10.1016/j.bmcl.2007.01.093
		10287730	3536	40	None	-630	12	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human 5-hydroxytryptamine 7 receptor Binding affinity for human 5-hydroxytryptamine 7 receptor	ChEMBL	412	6	0	5	4.3	Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2	10.1021/jm049039v
		77	3536	40	None	-630	12	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human 5-hydroxytryptamine 7 receptor Binding affinity for human 5-hydroxytryptamine 7 receptor	ChEMBL	412	6	0	5	4.3	Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2	10.1021/jm049039v
		CHEMBL425190	3536	40	None	-630	12	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human 5-hydroxytryptamine 7 receptor Binding affinity for human 5-hydroxytryptamine 7 receptor	ChEMBL	412	6	0	5	4.3	Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2	10.1021/jm049039v
		11304596	56396	0	None	-3162	9	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	416	5	0	5	3.9	Cc1ccc2c(N3CCN(CCc4cccc(N5CCOC5=O)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1631542	56396	0	None	-3162	9	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	416	5	0	5	3.9	Cc1ccc2c(N3CCN(CCc4cccc(N5CCOC5=O)c4)CC3)cccc2n1	10.1021/jm100714c
		134133633	154592	0	None	-3	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	407	5	0	1	6.9	Clc1ccc(C(=CCCN2CCc3ccccc3C2)c2ccc(Cl)cc2)cc1	10.1016/j.bmc.2016.09.019
		CHEMBL3899822	154592	0	None	-3	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	407	5	0	1	6.9	Clc1ccc(C(=CCCN2CCc3ccccc3C2)c2ccc(Cl)cc2)cc1	10.1016/j.bmc.2016.09.019
		CHEMBL3991400	154592	0	None	-3	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	407	5	0	1	6.9	Clc1ccc(C(=CCCN2CCc3ccccc3C2)c2ccc(Cl)cc2)cc1	10.1016/j.bmc.2016.09.019
		1220	187	55	None	-208	44	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.ejmech.2019.111705
		31	187	55	None	-208	44	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.ejmech.2019.111705
		7	187	55	None	-208	44	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.ejmech.2019.111705
		CHEMBL56	187	55	None	-208	44	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.ejmech.2019.111705
		135367400	163971	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	228	1	1	3	2.3	Cc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
		CHEMBL4207901	163971	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	228	1	1	3	2.3	Cc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
		127052778	140845	0	None	-3	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	505	9	0	5	6.3	O=C(CCCCN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
		CHEMBL3819403	140845	0	None	-3	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	505	9	0	5	6.3	O=C(CCCCN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
		5242341	198156	2	None	-30	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	396	6	0	5	3.7	O=c1c2ccccc2ncn1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2015.02.042
		CHEMBL574827	198156	2	None	-30	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	396	6	0	5	3.7	O=c1c2ccccc2ncn1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2015.02.042
		135367400	163971	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	228	1	1	3	2.3	Cc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
		CHEMBL4207901	163971	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	228	1	1	3	2.3	Cc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
		46204733	124572	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	264	3	1	3	2.9	Cc1ccccc1-c1ccc(C#N)c(OC2CNC2)c1	nan
		CHEMBL3640579	124572	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	264	3	1	3	2.9	Cc1ccccc1-c1ccc(C#N)c(OC2CNC2)c1	nan
		46204733	124572	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	264	3	1	3	2.9	Cc1ccccc1-c1ccc(C#N)c(OC2CNC2)c1	nan
		CHEMBL3640579	124572	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	264	3	1	3	2.9	Cc1ccccc1-c1ccc(C#N)c(OC2CNC2)c1	nan
		155552213	176658	0	None	-54	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.5	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4546775	176658	0	None	-54	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.5	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4598090	176658	0	None	-54	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.5	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmc.2019.06.028
		164615243	185210	0	None	-21	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	5	1	7	3.0	CCC(Oc1ccc(Cl)c(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
		CHEMBL4857676	185210	0	None	-21	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	5	1	7	3.0	CCC(Oc1ccc(Cl)c(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
		90654671	110092	0	None	-2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	466	8	1	5	3.1	CSc1ccccc1N1CCN(CCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235743	110092	0	None	-2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	466	8	1	5	3.1	CSc1ccccc1N1CCN(CCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
		145984511	165624	0	None	-5	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	493	6	0	7	3.8	O=S(=O)(c1cncc2ccccc12)N1CC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4243497	165624	0	None	-5	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	493	6	0	7	3.8	O=S(=O)(c1cncc2ccccc12)N1CC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
		156016856	177676	0	None	-39	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	295	2	0	1	4.4	Fc1ccccc1-c1cccc2c1CCC(N1CCCC1)C2	10.1016/j.bmc.2019.115262
		CHEMBL4641769	177676	0	None	-39	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	295	2	0	1	4.4	Fc1ccccc1-c1cccc2c1CCC(N1CCCC1)C2	10.1016/j.bmc.2019.115262
		155513438	169729	0	None	-10	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	346	6	3	3	4.8	Cc1ccc2[nH]cc(CCNCc3ccc(-c4ccc(O)cc4)o3)c2c1	10.1016/j.ejmech.2019.111857
		CHEMBL4438434	169729	0	None	-10	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	346	6	3	3	4.8	Cc1ccc2[nH]cc(CCNCc3ccc(-c4ccc(O)cc4)o3)c2c1	10.1016/j.ejmech.2019.111857
		56945042	158041	0	None	-4	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	449	6	2	3	4.5	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(Cl)cc1	10.1021/acs.jmedchem.7b00839
		CHEMBL4085802	158041	0	None	-4	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	449	6	2	3	4.5	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(Cl)cc1	10.1021/acs.jmedchem.7b00839
		44424659	85770	0	None	-4	2	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	474	8	0	9	2.1	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2007.05.017
		CHEMBL229231	85770	0	None	-4	2	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	474	8	0	9	2.1	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2007.05.017
		CHEMBL2448068	85770	0	None	-4	2	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	474	8	0	9	2.1	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2007.05.017
		127052467	140851	0	None	-1	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	1	1	4.5	c1ccc2c(c1)CCN(CCCCc1c[nH]c3ccccc13)C2	10.1016/j.bmc.2016.05.053
		CHEMBL3819494	140851	0	None	-1	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	1	1	4.5	c1ccc2c(c1)CCN(CCCCc1c[nH]c3ccccc13)C2	10.1016/j.bmc.2016.05.053
		11747350	107332	0	None	-25	10	Human	6.3	pKi	=	6.3	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	260	5	1	3	2.4	CCOC(=O)c1[nH]c2ccccc2c1CCN(C)C	10.1021/jm010943m
		CHEMBL317535	107332	0	None	-25	10	Human	6.3	pKi	=	6.3	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	260	5	1	3	2.4	CCOC(=O)c1[nH]c2ccccc2c1CCN(C)C	10.1021/jm010943m
		118736366	118938	0	None	-257	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	465	6	1	10	1.3	Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCN1CCN(c2ccccc2O)CC1	10.1016/j.ejmech.2015.04.046
		CHEMBL3423330	118938	0	None	-257	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	465	6	1	10	1.3	Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCN1CCN(c2ccccc2O)CC1	10.1016/j.ejmech.2015.04.046
		25263297	184337	0	None	-645	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	394	5	2	6	2.7	NCCC(=O)Nc1cccc2c1cnn2S(=O)(=O)c1cccc2ccccc12	10.1016/j.bmcl.2009.03.071
		CHEMBL484345	184337	0	None	-645	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	394	5	2	6	2.7	NCCC(=O)Nc1cccc2c1cnn2S(=O)(=O)c1cccc2ccccc12	10.1016/j.bmcl.2009.03.071
		135464118	93060	0	None	-14	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	304	1	4	2	1.9	N=C1NC(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1	10.1016/j.bmc.2013.09.011
		CHEMBL2442272	93060	0	None	-14	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	304	1	4	2	1.9	N=C1NC(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1	10.1016/j.bmc.2013.09.011
		122483262	138089	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	370	7	0	3	5.7	CN(CCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
		CHEMBL3763883	138089	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	370	7	0	3	5.7	CN(CCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
		CHEMBL3765837	138089	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	370	7	0	3	5.7	CN(CCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
		60167452	75354	0	None	-28	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	448	7	1	6	4.1	O=C(CCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
		CHEMBL2037526	75354	0	None	-28	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	448	7	1	6	4.1	O=C(CCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
		6604117	187847	6	None	-5	6	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	325	5	2	3	3.8	C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
		CHEMBL2062340	187847	6	None	-5	6	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	325	5	2	3	3.8	C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
		CHEMBL49623	187847	6	None	-5	6	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	325	5	2	3	3.8	C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
		122483262	138089	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	370	7	0	3	5.7	CN(CCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
		CHEMBL3763883	138089	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	370	7	0	3	5.7	CN(CCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
		CHEMBL3765837	138089	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	370	7	0	3	5.7	CN(CCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
		155562918	175183	0	None	-5	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	314	4	1	7	1.1	Cc1ccccc1OCc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
		CHEMBL4570584	175183	0	None	-5	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	314	4	1	7	1.1	Cc1ccccc1OCc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
		162674513	183778	0	None	-12	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	9	1	4	5.3	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4798559	183778	0	None	-12	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	9	1	4	5.3	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4804009	183778	0	None	-12	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	9	1	4	5.3	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
		122181340	121882	0	None	-14	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	460	7	1	4	4.2	O=C1NC2(CCC(c3ccccc3)CC2)C(=O)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2015.04.026
		CHEMBL3590092	121882	0	None	-14	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	460	7	1	4	4.2	O=C1NC2(CCC(c3ccccc3)CC2)C(=O)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2015.04.026
		162661627	183709	0	None	-7	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	425	11	1	5	3.7	COc1ccccc1CNC(=O)CCCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4778919	183709	0	None	-7	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	425	11	1	5	3.7	COc1ccccc1CNC(=O)CCCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4803268	183709	0	None	-7	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	425	11	1	5	3.7	COc1ccccc1CNC(=O)CCCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.ejmech.2020.112437
		118464425	138309	0	None	-13	9	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	357	3	2	7	2.8	CCOC(=O)c1cccc(NC2=NC(N(C)C)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
		CHEMBL3770981	138309	0	None	-13	9	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	357	3	2	7	2.8	CCOC(=O)c1cccc(NC2=NC(N(C)C)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
		44582677	181573	0	None	-2	3	Human	5.3	pKi	=	5.3	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	432	10	1	6	3.9	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL476838	181573	0	None	-2	3	Human	5.3	pKi	=	5.3	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	432	10	1	6	3.9	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1	10.1016/j.bmc.2009.03.021
		60167452	75354	0	None	-28	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	448	7	1	6	4.1	O=C(CCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
		CHEMBL2037526	75354	0	None	-28	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	448	7	1	6	4.1	O=C(CCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
		60167452	75354	0	None	-28	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	448	7	1	6	4.1	O=C(CCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
		CHEMBL2037526	75354	0	None	-28	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	448	7	1	6	4.1	O=C(CCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
		46205372	124586	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	289	3	1	2	3.7	COc1ccc(-c2cccc(F)c2F)cc1C1CCNC1	nan
		CHEMBL3640592	124586	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	289	3	1	2	3.7	COc1ccc(-c2cccc(F)c2F)cc1C1CCNC1	nan
		10904975	164867	0	None	17	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	379	7	1	6	3.7	O=C(CCCCN1CCN(c2noc3ccccc23)CC1)c1ccccc1O	10.1021/jm020994z
		CHEMBL422008	164867	0	None	17	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	379	7	1	6	3.7	O=C(CCCCN1CCN(c2noc3ccccc23)CC1)c1ccccc1O	10.1021/jm020994z
		11327137	66740	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	403	8	1	5	2.5	COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1021/jm049743b
		CHEMBL185762	66740	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	403	8	1	5	2.5	COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1021/jm049743b
		46205372	124586	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	289	3	1	2	3.7	COc1ccc(-c2cccc(F)c2F)cc1C1CCNC1	nan
		CHEMBL3640592	124586	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	289	3	1	2	3.7	COc1ccc(-c2cccc(F)c2F)cc1C1CCNC1	nan
		CHEMBL5094680	215510	0	None	-3	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		137631892	156385	0	None	2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	5.2	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
		CHEMBL4066426	156385	0	None	2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	5.2	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
		137660741	159369	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	4.9	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
		CHEMBL4100470	159369	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	4.9	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
		145985718	165525	0	None	-7	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	521	6	0	7	4.6	O=S(=O)(c1cccc2ncccc12)N1CCCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4241081	165525	0	None	-7	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	521	6	0	7	4.6	O=S(=O)(c1cccc2ncccc12)N1CCCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
		118626169	165575	0	None	-7	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	7	3.4	O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4242268	165575	0	None	-7	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	7	3.4	O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/j.ejmech.2018.01.002
		134147124	149980	0	None	5	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	512	10	1	5	4.6	O=C(CCOCCN1CCN(c2ncccc2-c2ccccc2)CC1)NCc1ccc(C(F)(F)F)cc1	10.1016/j.ejmech.2016.05.005
		CHEMBL3950020	149980	0	None	5	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	512	10	1	5	4.6	O=C(CCOCCN1CCN(c2ncccc2-c2ccccc2)CC1)NCc1ccc(C(F)(F)F)cc1	10.1016/j.ejmech.2016.05.005
		145975106	163661	0	None	30	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	484	9	1	4	5.2	O=S(=O)(NC1CCN(CCCOc2ccccc2-c2ccccc2)CC1)c1cccc(Cl)c1	10.1016/j.bmc.2017.03.057
		CHEMBL4204459	163661	0	None	30	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	484	9	1	4	5.2	O=S(=O)(NC1CCN(CCCOc2ccccc2-c2ccccc2)CC1)c1cccc(Cl)c1	10.1016/j.bmc.2017.03.057
		145972875	164728	0	None	33	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	434	9	1	4	4.2	CC(C)c1ccccc1OCCCN1CCC(NS(=O)(=O)c2cccc(F)c2)CC1	10.1016/j.bmc.2017.03.057
		CHEMBL4217506	164728	0	None	33	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	434	9	1	4	4.2	CC(C)c1ccccc1OCCCN1CCC(NS(=O)(=O)c2cccc(F)c2)CC1	10.1016/j.bmc.2017.03.057
		109026949	174606	1	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	392	6	0	4	2.5	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2016.06.080
		CHEMBL4557369	174606	1	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	392	6	0	4	2.5	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2016.06.080
		54758296	66004	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	426	7	1	2	6.0	CCC1(CCCCN2CC=C(c3cccc(Cl)c3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm200547z
		CHEMBL1836793	66004	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	426	7	1	2	6.0	CCC1(CCCCN2CC=C(c3cccc(Cl)c3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm200547z
		127052467	140851	0	None	-1	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	1	1	4.5	c1ccc2c(c1)CCN(CCCCc1c[nH]c3ccccc13)C2	10.1016/j.bmc.2016.05.053
		CHEMBL3819494	140851	0	None	-1	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	1	1	4.5	c1ccc2c(c1)CCN(CCCCc1c[nH]c3ccccc13)C2	10.1016/j.bmc.2016.05.053
		122178702	121368	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	387	6	0	5	3.8	COc1cc2c(cc1OCCF)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
		CHEMBL3581247	121368	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	387	6	0	5	3.8	COc1cc2c(cc1OCCF)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
		CHEMBL5094680	215510	0	None	-3	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		135367820	164821	0	None	8	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		CHEMBL4218672	164821	0	None	8	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		11257340	122037	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	374	7	1	4	2.7	COc1ccc2c(c1)CCN(CCCNS(=O)(=O)c1ccc(C)cc1)C2	10.1021/jm049743b
		CHEMBL359538	122037	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	374	7	1	4	2.7	COc1ccc2c(c1)CCN(CCCNS(=O)(=O)c1ccc(C)cc1)C2	10.1021/jm049743b
		66801624	156502	0	None	-2	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	479	6	2	3	5.4	Cc1[nH]c2ccc(Cl)cc2c1C1=CCN(CCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1021/acs.jmedchem.7b00839
		CHEMBL4067700	156502	0	None	-2	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	479	6	2	3	5.4	Cc1[nH]c2ccc(Cl)cc2c1C1=CCN(CCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1021/acs.jmedchem.7b00839
		11568826	132798	0	None	-446	8	Human	6.3	pKi	=	6.3	Binding	Inhibitory activity against 5HT7 receptorInhibitory activity against 5HT7 receptor	ChEMBL	460	4	0	8	2.8	CN1CCc2c(sc3ncn(CCN4CCN(c5cncc6ccccc56)CC4)c(=O)c23)C1	10.1016/j.bmcl.2005.04.077
		CHEMBL370110	132798	0	None	-446	8	Human	6.3	pKi	=	6.3	Binding	Inhibitory activity against 5HT7 receptorInhibitory activity against 5HT7 receptor	ChEMBL	460	4	0	8	2.8	CN1CCc2c(sc3ncn(CCN4CCN(c5cncc6ccccc56)CC4)c(=O)c23)C1	10.1016/j.bmcl.2005.04.077
		156010209	177154	0	None	-4	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	251	2	0	1	3.8	CN(C)[C@@H]1CCc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2019.115262
		CHEMBL4634062	177154	0	None	-4	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	251	2	0	1	3.8	CN(C)[C@@H]1CCc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2019.115262
		164620748	186245	0	None	-147	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	396	5	1	7	3.0	CCC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2022.114645
		CHEMBL4873623	186245	0	None	-147	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	396	5	1	7	3.0	CCC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2022.114645
		164620748	186245	0	None	-147	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	5	1	7	3.0	CCC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
		CHEMBL4873623	186245	0	None	-147	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	5	1	7	3.0	CCC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
		16026344	22250	4	None	-1	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	373	2	0	3	5.0	O=S1(=O)c2ccccc2N(Cc2ccc(Cl)cc2F)c2ccccc21	10.1016/j.bmcl.2015.03.049
		CHEMBL1323386	22250	4	None	-1	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	373	2	0	3	5.0	O=S1(=O)c2ccccc2N(Cc2ccc(Cl)cc2F)c2ccccc21	10.1016/j.bmcl.2015.03.049
		155555506	174382	0	None	-8	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	330	6	1	2	5.1	CN(CCc1c[nH]c2ccccc12)Cc1ccc(-c2ccccc2)o1	10.1016/j.ejmech.2019.111857
		CHEMBL4552041	174382	0	None	-8	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	330	6	1	2	5.1	CN(CCc1c[nH]c2ccccc12)Cc1ccc(-c2ccccc2)o1	10.1016/j.ejmech.2019.111857
		46205041	124576	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	337	5	1	3	4.0	Cc1ccccc1-c1ccc(OCC(F)(F)F)c(OC2CNC2)c1	nan
		CHEMBL3640582	124576	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	337	5	1	3	4.0	Cc1ccccc1-c1ccc(OCC(F)(F)F)c(OC2CNC2)c1	nan
		46205041	124576	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	337	5	1	3	4.0	Cc1ccccc1-c1ccc(OCC(F)(F)F)c(OC2CNC2)c1	nan
		CHEMBL3640582	124576	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	337	5	1	3	4.0	Cc1ccccc1-c1ccc(OCC(F)(F)F)c(OC2CNC2)c1	nan
		164624803	186212	0	None	-28	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	424	7	1	7	3.8	CCCCC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
		CHEMBL4873127	186212	0	None	-28	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	424	7	1	7	3.8	CCCCC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
		145978472	163603	0	None	14	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	438	4	1	4	2.7	O=C(c1ccc(Cl)cc1)N1CCN(CCN2CCC3(C2)C(=O)Nc2ccccc23)CC1	10.1016/j.bmcl.2018.06.019
		CHEMBL4203581	163603	0	None	14	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	438	4	1	4	2.7	O=C(c1ccc(Cl)cc1)N1CCN(CCN2CCC3(C2)C(=O)Nc2ccccc23)CC1	10.1016/j.bmcl.2018.06.019
		127027388	137651	0	None	10	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	437	8	1	5	3.6	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccnc1	10.1016/j.ejmech.2015.11.040
		CHEMBL3758378	137651	0	None	10	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	437	8	1	5	3.6	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccnc1	10.1016/j.ejmech.2015.11.040
		127042841	137005	0	None	3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	488	9	0	4	5.1	CC(C)(C)c1ccccc1OCCN1CCC(N(CC2CC2)S(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2015.11.041
		CHEMBL3746083	137005	0	None	3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	488	9	0	4	5.1	CC(C)(C)c1ccccc1OCCN1CCC(N(CC2CC2)S(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2015.11.041
		76284193	146597	0	None	19	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	444	10	1	5	3.6	O=C(CCOCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1	10.1016/j.ejmech.2016.05.005
		CHEMBL3923145	146597	0	None	19	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	444	10	1	5	3.6	O=C(CCOCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1	10.1016/j.ejmech.2016.05.005
		156012741	177287	0	None	-2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	477	8	0	4	4.4	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2020.115459
		CHEMBL4636435	177287	0	None	-2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	477	8	0	4	4.4	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2020.115459
		155538367	172381	0	None	30	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	263	2	1	2	3.8	CCn1cncc1-c1c[nH]c2ccc(Cl)c(F)c12	10.1016/j.ejmech.2019.03.017
		CHEMBL4476372	172381	0	None	30	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	263	2	1	2	3.8	CCn1cncc1-c1c[nH]c2ccc(Cl)c(F)c12	10.1016/j.ejmech.2019.03.017
		155541872	176685	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	447	8	0	3	5.8	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4519312	176685	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	447	8	0	3	5.8	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4598357	176685	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	447	8	0	3	5.8	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
		44408820	140905	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	369	6	0	3	4.3	O=S(=O)(c1ccccc1)C1(CCN2CCC(c3ccccc3)C2)CCC1	10.1016/j.bmcl.2005.11.067
		CHEMBL382163	140905	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	369	6	0	3	4.3	O=S(=O)(c1ccccc1)C1(CCN2CCC(c3ccccc3)C2)CCC1	10.1016/j.bmcl.2005.11.067
		24854370	157070	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3ccccc3Cl)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
		CHEMBL407412	157070	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3ccccc3Cl)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
		135367820	164821	0	None	8	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		CHEMBL4218672	164821	0	None	8	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		134130462	142313	0	None	-2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	390	7	0	5	3.7	Cc1nc2ccccc2c(=O)n1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2016.12.039
		CHEMBL3885389	142313	0	None	-2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	390	7	0	5	3.7	Cc1nc2ccccc2c(=O)n1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2016.12.039
		44439400	91214	0	None	2	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	408	7	0	4	5.2	CCCOC1CCCc2ccc(/N=C/N3CCc4cc(OC)c(OC)cc4C3)cc21	10.1016/j.bmcl.2007.01.093
		CHEMBL240023	91214	0	None	2	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	408	7	0	4	5.2	CCCOC1CCCc2ccc(/N=C/N3CCc4cc(OC)c(OC)cc4C3)cc21	10.1016/j.bmcl.2007.01.093
		138691317	171537	0	None	5	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	211	2	1	2	3.1	CCn1cncc1-c1c[nH]c2ccccc12	10.1016/j.ejmech.2019.03.017
		CHEMBL4464377	171537	0	None	5	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	211	2	1	2	3.1	CCn1cncc1-c1c[nH]c2ccccc12	10.1016/j.ejmech.2019.03.017
		155548677	173728	0	None	-257	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	376	7	3	4	4.8	COc1ccc2[nH]c(C)c(CCNCc3ccc(-c4ccc(O)cc4)o3)c2c1	10.1016/j.ejmech.2019.111857
		CHEMBL4536315	173728	0	None	-257	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	376	7	3	4	4.8	COc1ccc2[nH]c(C)c(CCNCc3ccc(-c4ccc(O)cc4)o3)c2c1	10.1016/j.ejmech.2019.111857
		46204419	124560	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	331	5	0	3	4.5	COc1ccc(-c2ccccc2Cl)cc1OC1CN(C(C)C)C1	nan
		CHEMBL3640567	124560	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	331	5	0	3	4.5	COc1ccc(-c2ccccc2Cl)cc1OC1CN(C(C)C)C1	nan
		46204419	124560	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	331	5	0	3	4.5	COc1ccc(-c2ccccc2Cl)cc1OC1CN(C(C)C)C1	nan
		CHEMBL3640567	124560	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	331	5	0	3	4.5	COc1ccc(-c2ccccc2Cl)cc1OC1CN(C(C)C)C1	nan
		53323535	57025	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	356	3	1	2	5.2	Clc1ccc(-c2cn(Cc3cccc(Cl)c3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
		CHEMBL1644487	57025	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	356	3	1	2	5.2	Clc1ccc(-c2cn(Cc3cccc(Cl)c3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
		145975778	163581	0	None	4	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	374	7	1	4	2.8	Cc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccccc2)CC1	10.1021/acs.jmedchem.8b00828
		CHEMBL4203312	163581	0	None	4	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	374	7	1	4	2.8	Cc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccccc2)CC1	10.1021/acs.jmedchem.8b00828
		136118659	76255	0	None	-3	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	346	1	1	2	2.7	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1C	10.1016/j.bmc.2013.09.011
		CHEMBL2058427	76255	0	None	-3	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	346	1	1	2	2.7	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1C	10.1016/j.bmc.2013.09.011
		71602523	89691	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	328	4	0	2	4.7	c1ccc(-c2ccccc2CN2CCN(c3ccccc3)CC2)cc1	10.1016/j.bmc.2013.02.038
		CHEMBL2376463	89691	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	328	4	0	2	4.7	c1ccc(-c2ccccc2CN2CCN(c3ccccc3)CC2)cc1	10.1016/j.bmc.2013.02.038
		71602523	89691	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	328	4	0	2	4.7	c1ccc(-c2ccccc2CN2CCN(c3ccccc3)CC2)cc1	10.1016/j.bmc.2013.02.038
		CHEMBL2376463	89691	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	328	4	0	2	4.7	c1ccc(-c2ccccc2CN2CCN(c3ccccc3)CC2)cc1	10.1016/j.bmc.2013.02.038
		52952419	62581	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	358	5	0	5	3.3	O=C(CCN1CCC(N2CCOCC2)CC1)c1csc2ccccc12	10.1021/jm2000773
		CHEMBL1782794	62581	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	358	5	0	5	3.3	O=C(CCN1CCC(N2CCOCC2)CC1)c1csc2ccccc12	10.1021/jm2000773
		10662302	99348	0	None	-2	5	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	304	1	1	2	3.0	CC(=O)N[C@@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
		CHEMBL282375	99348	0	None	-2	5	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	304	1	1	2	3.0	CC(=O)N[C@@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
		24768519	92863	0	None	1	3	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	461	8	1	3	5.9	CC(C)(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
		CHEMBL243953	92863	0	None	1	3	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	461	8	1	3	5.9	CC(C)(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
		44393053	65265	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	349	8	2	6	3.8	Cc1nc(NCCOc2ccccc2)nc(N[C@@H](C)c2ccccc2)n1	10.1016/j.bmcl.2004.06.008
		CHEMBL182805	65265	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	349	8	2	6	3.8	Cc1nc(NCCOc2ccccc2)nc(N[C@@H](C)c2ccccc2)n1	10.1016/j.bmcl.2004.06.008
		11372669	67418	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	388	8	0	4	3.2	CCN(CCCN1CCc2cc(OC)ccc2C1)S(=O)(=O)c1ccccc1	10.1021/jm049743b
		CHEMBL188876	67418	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	388	8	0	4	3.2	CCN(CCCN1CCc2cc(OC)ccc2C1)S(=O)(=O)c1ccccc1	10.1021/jm049743b
		76336184	106273	0	None	3	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	367	4	0	3	5.0	c1ccc(N2CCN(Cc3cn(-c4ccccc4)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
		CHEMBL3121434	106273	0	None	3	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	367	4	0	3	5.0	c1ccc(N2CCN(Cc3cn(-c4ccccc4)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
		CHEMBL3139017	106273	0	None	3	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	367	4	0	3	5.0	c1ccc(N2CCN(Cc3cn(-c4ccccc4)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
		127026443	137838	0	None	85	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	434	7	1	4	3.9	CC(C)(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
		CHEMBL3759925	137838	0	None	85	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	434	7	1	4	3.9	CC(C)(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
		134139826	146532	0	None	12	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	487	10	1	6	3.6	N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3ncccc3-c3ccc(F)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		CHEMBL3922670	146532	0	None	12	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	487	10	1	6	3.6	N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3ncccc3-c3ccc(F)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		156012823	177410	0	None	-2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	548	11	0	6	6.2	Cc1ccc(S(=O)(=O)N(CCCCCCN2CCN(c3nsc4ccccc34)CC2)c2ccccc2)cc1	10.1016/j.bmc.2020.115459
		CHEMBL4638388	177410	0	None	-2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	548	11	0	6	6.2	Cc1ccc(S(=O)(=O)N(CCCCCCN2CCN(c3nsc4ccccc34)CC2)c2ccccc2)cc1	10.1016/j.bmc.2020.115459
		21048822	140219	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	377	6	0	3	4.3	CC(C)(CCCN1CCCC(C(F)(F)F)C1)S(=O)(=O)c1ccccc1	10.1016/j.bmcl.2005.11.067
		CHEMBL380511	140219	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	377	6	0	3	4.3	CC(C)(CCCN1CCCC(C(F)(F)F)C1)S(=O)(=O)c1ccccc1	10.1016/j.bmcl.2005.11.067
		23661667	85764	0	None	-4	3	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	470	9	0	10	1.4	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2007.05.017
		CHEMBL1203946	85764	0	None	-4	3	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	470	9	0	10	1.4	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2007.05.017
		CHEMBL229181	85764	0	None	-4	3	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	470	9	0	10	1.4	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2007.05.017
		66801115	112064	0	None	-5	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	506	7	1	7	4.7	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
		CHEMBL3289959	112064	0	None	-5	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	506	7	1	7	4.7	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
		122178711	121377	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	509	6	0	5	5.8	COc1cc2c(cc1OCc1ccc(Br)cc1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
		CHEMBL3581256	121377	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	509	6	0	5	5.8	COc1cc2c(cc1OCc1ccc(Br)cc1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
		25108475	187485	0	None	-2	3	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	419	8	0	3	5.0	CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	10.1021/jm800615e
		CHEMBL494119	187485	0	None	-2	3	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	419	8	0	3	5.0	CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	10.1021/jm800615e
		23661667	85764	0	None	-4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	470	9	0	10	1.4	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2014.11.008
		CHEMBL1203946	85764	0	None	-4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	470	9	0	10	1.4	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2014.11.008
		CHEMBL229181	85764	0	None	-4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	470	9	0	10	1.4	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2014.11.008
		10333670	94786	0	None	-1	5	Rat	7.3	pKi	=	7.3	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	276	0	1	2	2.8	CN1CCc2ccc3c(=O)[nH]c4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
		CHEMBL253319	94786	0	None	-1	5	Rat	7.3	pKi	=	7.3	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	276	0	1	2	2.8	CN1CCc2ccc3c(=O)[nH]c4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
		155565209	175591	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	426	6	0	4	3.2	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2016.06.080
		CHEMBL4579764	175591	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	426	6	0	4	3.2	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2016.06.080
		155535154	172042	0	None	-10	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	556	9	1	7	5.2	COc1ccc(-c2c3n(c(=O)n(CCCCN4CCCC(c5c[nH]c6ccc(OC)cc56)C4)c2=O)CCCC3)cc1	10.1016/j.ejmech.2019.07.027
		CHEMBL4471755	172042	0	None	-10	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	556	9	1	7	5.2	COc1ccc(-c2c3n(c(=O)n(CCCCN4CCCC(c5c[nH]c6ccc(OC)cc56)C4)c2=O)CCCC3)cc1	10.1016/j.ejmech.2019.07.027
		145966154	164187	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	402	8	1	4	3.6	CC(C)c1cccc(OCCN2CCC(NS(=O)(=O)c3ccccc3)CC2)c1	10.1021/acs.jmedchem.8b00828
		CHEMBL4210708	164187	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	402	8	1	4	3.6	CC(C)c1cccc(OCCN2CCC(NS(=O)(=O)c3ccccc3)CC2)c1	10.1021/acs.jmedchem.8b00828
		122483244	138095	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
		CHEMBL3764136	138095	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
		CHEMBL3765843	138095	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
		44448054	94785	0	None	1	6	Human	7.3	pKi	=	7.3	Binding	Binding affinity at 5HT7 receptorBinding affinity at 5HT7 receptor	ChEMBL	276	0	1	2	2.8	CN1CCc2ccc3[nH]c(=O)c4cccc5c4c3c2[C@H]1C5	10.1021/jm060959i
		CHEMBL253318	94785	0	None	1	6	Human	7.3	pKi	=	7.3	Binding	Binding affinity at 5HT7 receptorBinding affinity at 5HT7 receptor	ChEMBL	276	0	1	2	2.8	CN1CCc2ccc3[nH]c(=O)c4cccc5c4c3c2[C@H]1C5	10.1021/jm060959i
		132503215	157750	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	5.2	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1016/j.bmc.2017.04.046
		CHEMBL4082456	157750	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	5.2	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1016/j.bmc.2017.04.046
		57392107	68424	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	454	9	1	6	3.1	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2cccc3cccnc23)CC1	10.1016/j.bmc.2011.09.044
		CHEMBL1917345	68424	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	454	9	1	6	3.1	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2cccc3cccnc23)CC1	10.1016/j.bmc.2011.09.044
		145966418	164241	0	None	6	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	410	4	1	4	3.1	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3cccc(Cl)c3)CC1)C2	10.1016/j.bmcl.2018.06.019
		CHEMBL4211253	164241	0	None	6	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	410	4	1	4	3.1	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3cccc(Cl)c3)CC1)C2	10.1016/j.bmcl.2018.06.019
		46205703	124597	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	251	2	1	1	4.0	Cc1ccc(-c2ccccc2C2CCNC2)cc1C	nan
		CHEMBL3640603	124597	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	251	2	1	1	4.0	Cc1ccc(-c2ccccc2C2CCNC2)cc1C	nan
		46205703	124597	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	251	2	1	1	4.0	Cc1ccc(-c2ccccc2C2CCNC2)cc1C	nan
		CHEMBL3640603	124597	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	251	2	1	1	4.0	Cc1ccc(-c2ccccc2C2CCNC2)cc1C	nan
		44408987	76559	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	335	6	0	3	3.9	CC1CCN(CCCC2(S(=O)(=O)c3ccccc3)CCC2)CC1	10.1016/j.bmcl.2005.11.067
		CHEMBL206269	76559	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	335	6	0	3	3.9	CC1CCN(CCCC2(S(=O)(=O)c3ccccc3)CCC2)CC1	10.1016/j.bmcl.2005.11.067
		122483244	138095	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
		CHEMBL3764136	138095	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
		CHEMBL3765843	138095	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
		5280953	97362	109	None	-6	8	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	212	1	1	2	3.0	COc1ccc2c(c1)[nH]c1c(C)nccc12	10.1016/j.bmcl.2003.09.027
		CHEMBL269538	97362	109	None	-6	8	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	212	1	1	2	3.0	COc1ccc2c(c1)[nH]c1c(C)nccc12	10.1016/j.bmcl.2003.09.027
		3564	118148	86	None	-3	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assayDisplacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assay	ChEMBL	214	1	1	2	2.5	COc1ccc2c3c([nH]c2c1)C(C)=NCC3	10.1021/acs.jmedchem.0c01887
		CHEMBL1494278	118148	86	None	-3	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assayDisplacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assay	ChEMBL	214	1	1	2	2.5	COc1ccc2c3c([nH]c2c1)C(C)=NCC3	10.1021/acs.jmedchem.0c01887
		CHEMBL340807	118148	86	None	-3	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assayDisplacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assay	ChEMBL	214	1	1	2	2.5	COc1ccc2c3c([nH]c2c1)C(C)=NCC3	10.1021/acs.jmedchem.0c01887
		90654675	110096	0	None	-5	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	450	8	1	5	2.4	COc1ccccc1N1CCN(CCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235747	110096	0	None	-5	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	450	8	1	5	2.4	COc1ccccc1N1CCN(CCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
		46233381	201924	1	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	257	5	0	2	4.0	CN(C)CCSc1ccccc1-c1ccccc1	10.1016/j.bmc.2010.01.035
		CHEMBL607584	201924	1	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	257	5	0	2	4.0	CN(C)CCSc1ccccc1-c1ccccc1	10.1016/j.bmc.2010.01.035
		137645501	157645	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	4.9	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
		CHEMBL4081383	157645	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	4.9	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
		127028798	138184	0	None	23	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	454	6	2	5	2.4	Cc1ccc(C)c(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1	10.1016/j.ejmech.2016.02.024
		CHEMBL3769612	138184	0	None	23	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	454	6	2	5	2.4	Cc1ccc(C)c(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1	10.1016/j.ejmech.2016.02.024
		127039593	136990	0	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	460	10	0	6	3.5	CC(C)c1ccccc1OCCN1CCC(N(CC2CC2)S(=O)(=O)c2cnn(C)c2)CC1	10.1016/j.bmc.2015.11.041
		CHEMBL3745882	136990	0	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	460	10	0	6	3.5	CC(C)c1ccccc1OCCN1CCC(N(CC2CC2)S(=O)(=O)c2cnn(C)c2)CC1	10.1016/j.bmc.2015.11.041
		127042539	137084	0	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	474	10	0	4	4.9	CC(C)c1ccccc1OCCN1CCC(N(CC2CC2)S(=O)(=O)c2cccc(F)c2)CC1	10.1016/j.bmc.2015.11.041
		CHEMBL3747148	137084	0	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	474	10	0	4	4.9	CC(C)c1ccccc1OCCN1CCC(N(CC2CC2)S(=O)(=O)c2cccc(F)c2)CC1	10.1016/j.bmc.2015.11.041
		71574306	86266	0	None	-3	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2cn1	10.1016/j.ejmech.2012.11.042
		CHEMBL2312639	86266	0	None	-3	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2cn1	10.1016/j.ejmech.2012.11.042
		57325520	71538	0	None	-1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
		CHEMBL1949963	71538	0	None	-1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
		CHEMBL1962945	71538	0	None	-1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
		135	2532	43	None	-83	58	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
		1796	2532	43	None	-83	58	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
		4184	2532	43	None	-83	58	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
		CHEMBL6437	2532	43	None	-83	58	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
		DB06148	2532	43	None	-83	58	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
		155532137	171694	0	None	16	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	432	7	1	5	4.3	O=c1[nH]c(CCCCN2CCN(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
		CHEMBL4466596	171694	0	None	16	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	432	7	1	5	4.3	O=c1[nH]c(CCCCN2CCN(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
		168283140	191099	0	None	-34	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	463	7	0	8	3.3	COc1cc2ncnc(N3CCC(CN4CCN(c5ccccc5OC)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
		CHEMBL5187742	191099	0	None	-34	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	463	7	0	8	3.3	COc1cc2ncnc(N3CCC(CN4CCN(c5ccccc5OC)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
		10365873	67251	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	438	8	0	4	4.3	CCN(CCCN1CCc2cc(OC)ccc2C1)S(=O)(=O)c1cccc2ccccc12	10.1021/jm049743b
		CHEMBL188036	67251	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	438	8	0	4	4.3	CCN(CCCN1CCc2cc(OC)ccc2C1)S(=O)(=O)c1cccc2ccccc12	10.1021/jm049743b
		127052778	140845	0	None	-3	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	505	9	0	5	6.3	O=C(CCCCN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
		CHEMBL3819403	140845	0	None	-3	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	505	9	0	5	6.3	O=C(CCCCN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
		18377342	107113	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	350	5	2	3	3.2	O=C1Nc2cccc3c2C1(CCCCN1CCc2[nH]cnc2C1)CCC3	10.1016/s0960-894x(02)00485-7
		CHEMBL316039	107113	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	350	5	2	3	3.2	O=C1Nc2cccc3c2C1(CCCCN1CCc2[nH]cnc2C1)CCC3	10.1016/s0960-894x(02)00485-7
		145947762	167698	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	500	8	2	6	2.7	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(c3ccccc3)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
		CHEMBL4170484	167698	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	500	8	2	6	2.7	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(c3ccccc3)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
		CHEMBL4302327	167698	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	500	8	2	6	2.7	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(c3ccccc3)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
		42618256	181595	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	428	6	0	6	3.6	COc1ccc(-n2c(=O)n(CCN3CCN(c4ccccc4)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2009.02.008
		CHEMBL477065	181595	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	428	6	0	6	3.6	COc1ccc(-n2c(=O)n(CCN3CCN(c4ccccc4)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2009.02.008
		90654692	110078	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	438	6	1	5	2.8	CSc1ccccc1N1CCN(Cc2ccc(C(=O)N3CCC[C@H]3C(N)=O)cc2)CC1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235729	110078	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	438	6	1	5	2.8	CSc1ccccc1N1CCN(Cc2ccc(C(=O)N3CCC[C@H]3C(N)=O)cc2)CC1	10.1016/j.ejmech.2014.03.005
		155547197	173595	0	None	-758	7	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	341	6	0	4	3.4	O=C(CCCN1CCCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
		CHEMBL4533305	173595	0	None	-758	7	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	341	6	0	4	3.4	O=C(CCCN1CCCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
		145983468	165436	0	None	-5	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	493	6	0	7	3.8	O=S(=O)(c1cccc2ncccc12)N1CC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4238897	165436	0	None	-5	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	493	6	0	7	3.8	O=S(=O)(c1cccc2ncccc12)N1CC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
		90656677	112603	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	388	7	1	5	2.3	CN(CCN1CCN(c2ccccc2)CC1)c1cccc(NS(C)(=O)=O)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262402	112603	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	388	7	1	5	2.3	CN(CCN1CCN(c2ccccc2)CC1)c1cccc(NS(C)(=O)=O)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3302044	112603	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	388	7	1	5	2.3	CN(CCN1CCN(c2ccccc2)CC1)c1cccc(NS(C)(=O)=O)c1	10.1016/j.ejmech.2014.04.034
		44424666	144371	0	None	5	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	425	8	0	8	2.1	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCc2ccccc2C1	10.1016/j.bmc.2007.05.017
		CHEMBL390580	144371	0	None	5	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	425	8	0	8	2.1	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCc2ccccc2C1	10.1016/j.bmc.2007.05.017
		118706299	120537	0	None	-64	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	269	1	3	2	2.3	N=C(N)NC(=O)c1ccc2c(c1)C(F)c1ccccc1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3310121	120537	0	None	-64	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	269	1	3	2	2.3	N=C(N)NC(=O)c1ccc2c(c1)C(F)c1ccccc1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3545472	120537	0	None	-64	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	269	1	3	2	2.3	N=C(N)NC(=O)c1ccc2c(c1)C(F)c1ccccc1-2	10.1016/j.bmc.2014.05.027
		66801259	112095	0	None	2	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	471	8	1	8	3.3	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
		CHEMBL3289989	112095	0	None	2	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	471	8	1	8	3.3	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
		44401194	71295	0	None	-7	7	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	313	2	0	3	4.1	CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL195706	71295	0	None	-7	7	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	313	2	0	3	4.1	CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		118713594	114380	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	365	7	0	5	3.6	O=c1oc2ccccc2n1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
		CHEMBL3331263	114380	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	365	7	0	5	3.6	O=c1oc2ccccc2n1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
		44340882	9514	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	392	5	2	5	2.5	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3[nH]c(O)nc3c2)CC1	10.1016/s0960-894x(02)00690-x
		CHEMBL112150	9514	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	392	5	2	5	2.5	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3[nH]c(O)nc3c2)CC1	10.1016/s0960-894x(02)00690-x
		155554837	174636	0	None	-4	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	387	4	0	4	3.8	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cn2)CC1	10.1016/j.bmc.2020.115943
		CHEMBL4558031	174636	0	None	-4	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	387	4	0	4	3.8	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cn2)CC1	10.1016/j.bmc.2020.115943
		168283630	191289	0	None	-57	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	458	6	0	6	3.6	N#Cc1cccnc1N1CCN(CCCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1016/j.ejmech.2022.114193
		CHEMBL5190788	191289	0	None	-57	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	458	6	0	6	3.6	N#Cc1cccnc1N1CCN(CCCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1016/j.ejmech.2022.114193
		49783209	17609	0	None	-2884	26	Human	5.2	pKi	=	5.2	Binding	Binding affinity to human 5-HT7 receptorBinding affinity to human 5-HT7 receptor	ChEMBL	396	7	1	6	3.8	CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1	10.1021/jm100668r
		CHEMBL1258223	17609	0	None	-2884	26	Human	5.2	pKi	=	5.2	Binding	Binding affinity to human 5-HT7 receptorBinding affinity to human 5-HT7 receptor	ChEMBL	396	7	1	6	3.8	CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1	10.1021/jm100668r
		164618100	185360	0	None	-128	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	396	5	1	7	3.0	CCC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2022.114645
		CHEMBL4860275	185360	0	None	-128	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	396	5	1	7	3.0	CCC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2022.114645
		44437331	90963	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	734	21	0	8	8.2	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		CHEMBL239530	90963	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	734	21	0	8	8.2	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
		44424663	138144	0	None	-5	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	397	6	0	8	1.3	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCc2ccccc2C1	10.1016/j.bmc.2007.05.017
		CHEMBL376773	138144	0	None	-5	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	397	6	0	8	1.3	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCc2ccccc2C1	10.1016/j.bmc.2007.05.017
		CHEMBL4518342	213972	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000744a HTR7Selectivity interaction (GPCR panel (PDSP screen)) EUB0000744a HTR7	ChEMBL		None	None	None		CC(C)CC(=O)N1CCc2nc(-c3ccc(Br)cc3)nc(N(C)Cc3ccccc3)c2C1	10.6019/CHEMBL5212743
		90654677	110098	0	None	-7	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	484	6	1	5	3.1	COc1ccccc1N1CCN(Cc2ccc(C(=O)N3Cc4ccccc4C[C@H]3C(N)=O)cc2)CC1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235749	110098	0	None	-7	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	484	6	1	5	3.1	COc1ccccc1N1CCN(Cc2ccc(C(=O)N3Cc4ccccc4C[C@H]3C(N)=O)cc2)CC1	10.1016/j.ejmech.2014.03.005
		9978683	18674	0	None	-363	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cells	ChEMBL	406	3	1	5	3.3	CN1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)CC1	10.1021/jm1007825
		CHEMBL1277104	18674	0	None	-363	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cells	ChEMBL	406	3	1	5	3.3	CN1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)CC1	10.1021/jm1007825
		127041563	137004	0	None	5	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	448	7	0	4	4.3	CN(C1CCN(CCOc2ccccc2C(C)(C)C)CC1)S(=O)(=O)c1ccc(F)cc1	10.1016/j.bmc.2015.11.041
		CHEMBL3746079	137004	0	None	5	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	448	7	0	4	4.3	CN(C1CCN(CCOc2ccccc2C(C)(C)C)CC1)S(=O)(=O)c1ccc(F)cc1	10.1016/j.bmc.2015.11.041
		127041564	137051	0	None	4	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	434	7	0	6	2.9	CN(C1CCN(CCOc2ccccc2C(C)(C)C)CC1)S(=O)(=O)c1cnn(C)c1	10.1016/j.bmc.2015.11.041
		CHEMBL3746771	137051	0	None	4	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	434	7	0	6	2.9	CN(C1CCN(CCOc2ccccc2C(C)(C)C)CC1)S(=O)(=O)c1cnn(C)c1	10.1016/j.bmc.2015.11.041
		71453279	81432	0	None	1	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	454	7	1	5	4.1	O=S(=O)(NC1CCN(CCOc2cc(Cl)ccc2Cl)C1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159475	81432	0	None	1	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	454	7	1	5	4.1	O=S(=O)(NC1CCN(CCOc2cc(Cl)ccc2Cl)C1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
		145976292	163632	0	None	31	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	468	9	1	4	4.7	O=S(=O)(NC1CCN(CCCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2017.03.057
		CHEMBL4203908	163632	0	None	31	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	468	9	1	4	4.7	O=S(=O)(NC1CCN(CCCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2017.03.057
		155554837	174636	0	None	-4	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	387	4	0	4	3.8	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cn2)CC1	10.1016/j.bmc.2020.115943
		CHEMBL4558031	174636	0	None	-4	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	387	4	0	4	3.8	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cn2)CC1	10.1016/j.bmc.2020.115943
		155562543	175172	0	None	1	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	353	4	0	4	3.2	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccccn2)CC1	10.1016/j.bmc.2020.115943
		CHEMBL4570411	175172	0	None	1	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	353	4	0	4	3.2	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccccn2)CC1	10.1016/j.bmc.2020.115943
		122178701	121367	0	None	-1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	425	9	0	5	5.4	CCCCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
		CHEMBL3581246	121367	0	None	-1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	425	9	0	5	5.4	CCCCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
		155562543	175172	0	None	1	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	353	4	0	4	3.2	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccccn2)CC1	10.1016/j.bmc.2020.115943
		CHEMBL4570411	175172	0	None	1	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	353	4	0	4	3.2	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccccn2)CC1	10.1016/j.bmc.2020.115943
		25263302	191984	0	None	-4466	5	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	434	4	2	6	3.4	O=C(Nc1ccc2cnn(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCCNC1	10.1016/j.bmcl.2009.03.071
		CHEMBL520129	191984	0	None	-4466	5	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	434	4	2	6	3.4	O=C(Nc1ccc2cnn(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCCNC1	10.1016/j.bmcl.2009.03.071
		56673112	66367	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	491	7	0	8	4.0	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(-c3ncccn3)cc2)CC1	10.1016/j.ejmech.2011.04.060
		CHEMBL1851637	66367	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	491	7	0	8	4.0	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(-c3ncccn3)cc2)CC1	10.1016/j.ejmech.2011.04.060
		CHEMBL3216275	66367	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	491	7	0	8	4.0	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(-c3ncccn3)cc2)CC1	10.1016/j.ejmech.2011.04.060
		44408988	166067	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	336	6	0	4	2.4	CN1CCN(CCCC2(S(=O)(=O)c3ccccc3)CCC2)CC1	10.1016/j.bmcl.2005.11.067
		CHEMBL425767	166067	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	336	6	0	4	2.4	CN1CCN(CCCC2(S(=O)(=O)c3ccccc3)CCC2)CC1	10.1016/j.bmcl.2005.11.067
		155538814	173263	0	None	-38	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	334	4	1	7	1.4	CN1CCN(c2nc(N)nc(COc3cccc(Cl)c3)n2)CC1	10.1016/j.ejmech.2019.06.022
		CHEMBL4524981	173263	0	None	-38	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	334	4	1	7	1.4	CN1CCN(c2nc(N)nc(COc3cccc(Cl)c3)n2)CC1	10.1016/j.ejmech.2019.06.022
		168283609	191237	0	None	-2	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	418	10	5	8	3.1	COc1ccccc1NCCNc1nc(N)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
		CHEMBL5190020	191237	0	None	-2	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	418	10	5	8	3.1	COc1ccccc1NCCNc1nc(N)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
		155544139	173353	0	None	-30	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	348	4	1	7	1.7	Cc1cc(OCc2nc(N)nc(N3CCN(C)CC3)n2)ccc1Cl	10.1016/j.ejmech.2019.06.022
		CHEMBL4527124	173353	0	None	-30	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	348	4	1	7	1.7	Cc1cc(OCc2nc(N)nc(N3CCN(C)CC3)n2)ccc1Cl	10.1016/j.ejmech.2019.06.022
		122483228	138012	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.3	CC1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3764661	138012	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.3	CC1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		155556527	174510	0	None	-7	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	247	2	1	2	3.3	CCn1cncc1-c1c[nH]c2ccc(F)c(F)c12	10.1016/j.ejmech.2019.03.017
		CHEMBL4555115	174510	0	None	-7	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	247	2	1	2	3.3	CCn1cncc1-c1c[nH]c2ccc(F)c(F)c12	10.1016/j.ejmech.2019.03.017
		72198014	89818	0	None	-18	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	484	7	2	4	4.8	COc1ccc2[nH]cc(C3CCN(CCCN4C(=O)CC(c5c[nH]c6ccccc56)C4=O)CC3)c2c1	10.1016/j.ejmech.2013.02.033
		CHEMBL2377443	89818	0	None	-18	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	484	7	2	4	4.8	COc1ccc2[nH]cc(C3CCN(CCCN4C(=O)CC(c5c[nH]c6ccccc56)C4=O)CC3)c2c1	10.1016/j.ejmech.2013.02.033
		71458624	81367	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	400	7	1	3	4.5	Cc1ccccc1C(=O)NC1CCN(CCOc2ccccc2-c2ccccc2)C1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159315	81367	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	400	7	1	3	4.5	Cc1ccccc1C(=O)NC1CCN(CCOc2ccccc2-c2ccccc2)C1	10.1016/j.ejmech.2012.07.043
		145966199	164267	0	None	22	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	484	9	2	5	3.7	O=S(=O)(NC1CCN(CC(O)COc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2017.03.057
		CHEMBL4211665	164267	0	None	22	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	484	9	2	5	3.7	O=S(=O)(NC1CCN(CC(O)COc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2017.03.057
		44582675	189701	0	None	1	15	Human	7.2	pKi	=	7.2	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL515472	189701	0	None	1	15	Human	7.2	pKi	=	7.2	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		46206346	124609	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	351	4	1	3	4.5	COc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CCNCC1	nan
		CHEMBL3640614	124609	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	351	4	1	3	4.5	COc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CCNCC1	nan
		46206346	124609	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	351	4	1	3	4.5	COc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CCNCC1	nan
		CHEMBL3640614	124609	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	351	4	1	3	4.5	COc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CCNCC1	nan
		10992240	53548	0	None	-2	2	Rat	7.2	pKi	=	7.2	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	368	8	1	5	3.6	COc1ccccc1N1CCN(CCCCC(=O)c2ccc(O)cc2)CC1	10.1021/jm020994z
		CHEMBL160194	53548	0	None	-2	2	Rat	7.2	pKi	=	7.2	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	368	8	1	5	3.6	COc1ccccc1N1CCN(CCCCC(=O)c2ccc(O)cc2)CC1	10.1021/jm020994z
		25130235	187587	1	None	-169	11	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm8005959
		CHEMBL494678	187587	1	None	-169	11	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm8005959
		122483228	138012	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.3	CC1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3764661	138012	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.3	CC1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		164615340	185429	0	None	-25	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	382	4	1	7	2.7	CC(Oc1ccc(Cl)c(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
		CHEMBL4861431	185429	0	None	-25	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	382	4	1	7	2.7	CC(Oc1ccc(Cl)c(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
		155530351	176284	0	None	-6	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	5.8	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4464370	176284	0	None	-6	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	5.8	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1	10.1016/j.bmc.2019.06.028
		CHEMBL4595115	176284	0	None	-6	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	5.8	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1	10.1016/j.bmc.2019.06.028
		44393133	64848	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	318	7	2	4	4.3	CC(Nc1nccc(NCCc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		CHEMBL182070	64848	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	318	7	2	4	4.3	CC(Nc1nccc(NCCc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		9945703	66681	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	336	7	2	4	4.4	CC(Nc1ccnc(NCCc2ccc(F)cc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		CHEMBL185437	66681	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	336	7	2	4	4.4	CC(Nc1ccnc(NCCc2ccc(F)cc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
		2865	4143	73	None	-12	53	Human	8.2	pKi	=	8.2	Binding	Binding affinity to 5HT7 receptor (unknown origin) by radioligand binding assayBinding affinity to 5HT7 receptor (unknown origin) by radioligand binding assay	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm400856t
		59	4143	73	None	-12	53	Human	8.2	pKi	=	8.2	Binding	Binding affinity to 5HT7 receptor (unknown origin) by radioligand binding assayBinding affinity to 5HT7 receptor (unknown origin) by radioligand binding assay	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm400856t
		60854	4143	73	None	-12	53	Human	8.2	pKi	=	8.2	Binding	Binding affinity to 5HT7 receptor (unknown origin) by radioligand binding assayBinding affinity to 5HT7 receptor (unknown origin) by radioligand binding assay	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm400856t
		CHEMBL708	4143	73	None	-12	53	Human	8.2	pKi	=	8.2	Binding	Binding affinity to 5HT7 receptor (unknown origin) by radioligand binding assayBinding affinity to 5HT7 receptor (unknown origin) by radioligand binding assay	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm400856t
		DB00246	4143	73	None	-12	53	Human	8.2	pKi	=	8.2	Binding	Binding affinity to 5HT7 receptor (unknown origin) by radioligand binding assayBinding affinity to 5HT7 receptor (unknown origin) by radioligand binding assay	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm400856t
		44456033	155567	3	None	-4	8	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	195	0	2	3	2.0	C[C@@H]1NC(N)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.078
		CHEMBL404372	155567	3	None	-4	8	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	195	0	2	3	2.0	C[C@@H]1NC(N)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.078
		10202089	195746	0	None	87	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	417	4	3	4	3.4	COc1ccccc1N1CCN(C(=O)NC(=N)NCc2cccc3ccccc23)CC1	10.1016/j.bmcl.2009.06.038
		CHEMBL557330	195746	0	None	87	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	417	4	3	4	3.4	COc1ccccc1N1CCN(C(=O)NC(=N)NCc2cccc3ccccc23)CC1	10.1016/j.bmcl.2009.06.038
		145985585	165889	0	None	-1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	491	6	0	7	3.7	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4249640	165889	0	None	-1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	491	6	0	7	3.7	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
		71451459	81444	0	None	3	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	8	1	5	4.0	CC(C)c1ccccc1OCCN1CC[C@@H](NS(=O)(=O)c2ccc(Cl)s2)C1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159487	81444	0	None	3	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	8	1	5	4.0	CC(C)c1ccccc1OCCN1CC[C@@H](NS(=O)(=O)c2ccc(Cl)s2)C1	10.1016/j.ejmech.2012.07.043
		145946947	167602	0	None	31	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	452	8	2	6	2.0	CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
		CHEMBL4176950	167602	0	None	31	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	452	8	2	6	2.0	CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
		CHEMBL4300976	167602	0	None	31	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	452	8	2	6	2.0	CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
		145947404	167670	0	None	16	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	468	8	2	7	1.7	COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(c4ccccc4OC)CC3)C2=O)cc1	10.1016/j.ejmech.2018.01.093
		CHEMBL4163778	167670	0	None	16	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	468	8	2	7	1.7	COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(c4ccccc4OC)CC3)C2=O)cc1	10.1016/j.ejmech.2018.01.093
		CHEMBL4301967	167670	0	None	16	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	468	8	2	7	1.7	COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(c4ccccc4OC)CC3)C2=O)cc1	10.1016/j.ejmech.2018.01.093
		138691314	164636	1	None	173	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	337	2	1	2	3.7	CCn1cncc1-c1c[nH]c2ccc(I)cc12	10.1016/j.ejmech.2019.03.017
		CHEMBL4216263	164636	1	None	173	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	337	2	1	2	3.7	CCn1cncc1-c1c[nH]c2ccc(I)cc12	10.1016/j.ejmech.2019.03.017
		138691314	164636	1	None	173	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	337	2	1	2	3.7	CCn1cncc1-c1c[nH]c2ccc(I)cc12	10.1039/C8MD00313K
		CHEMBL4216263	164636	1	None	173	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	337	2	1	2	3.7	CCn1cncc1-c1c[nH]c2ccc(I)cc12	10.1039/C8MD00313K
		155537034	172285	0	None	36	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	240	2	2	3	1.7	Cn1cncc1-c1c[nH]c2ccc(C(N)=O)cc12	10.1039/C8MD00313K
		CHEMBL4474827	172285	0	None	36	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	240	2	2	3	1.7	Cn1cncc1-c1c[nH]c2ccc(C(N)=O)cc12	10.1039/C8MD00313K
		127039755	136653	0	None	14	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	470	8	1	4	4.8	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc(Cl)c1	10.1039/C5MD00166H
		CHEMBL3740055	136653	0	None	14	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	470	8	1	4	4.8	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc(Cl)c1	10.1039/C5MD00166H
		11151899	2137	13	None	-5	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1016/j.bmcl.2020.127669
		8432	2137	13	None	-5	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1016/j.bmcl.2020.127669
		CHEMBL4205783	2137	13	None	-5	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1016/j.bmcl.2020.127669
		11323169	179967	0	None	-6	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	269	2	1	3	3.1	Cc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
		CHEMBL4746737	179967	0	None	-6	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	269	2	1	3	3.1	Cc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
		56944953	159654	0	None	-2	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	463	7	2	3	4.9	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(Cl)cc1	10.1021/acs.jmedchem.7b00839
		CHEMBL4103725	159654	0	None	-2	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	463	7	2	3	4.9	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(Cl)cc1	10.1021/acs.jmedchem.7b00839
		155563911	175416	0	None	6	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	534	10	1	7	4.1	COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
		CHEMBL4575904	175416	0	None	6	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	534	10	1	7	4.1	COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
		138691314	164636	1	None	173	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes by Cheng-Prusoff equation analysisDisplacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes by Cheng-Prusoff equation analysis	ChEMBL	337	2	1	2	3.7	CCn1cncc1-c1c[nH]c2ccc(I)cc12	10.1021/acs.jmedchem.7b01898
		CHEMBL4216263	164636	1	None	173	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes by Cheng-Prusoff equation analysisDisplacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes by Cheng-Prusoff equation analysis	ChEMBL	337	2	1	2	3.7	CCn1cncc1-c1c[nH]c2ccc(I)cc12	10.1021/acs.jmedchem.7b01898
		11153067	76752	1	None	34	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	375	6	0	3	4.7	O=S(=O)(c1ccccc1)C1(CCCN2CCC3CCCCC3C2)CCC1	10.1016/j.bmcl.2005.11.067
		CHEMBL206748	76752	1	None	34	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	375	6	0	3	4.7	O=S(=O)(c1ccccc1)C1(CCCN2CCC3CCCCC3C2)CCC1	10.1016/j.bmcl.2005.11.067
		5	139	72	None	-3	54	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
		5202	139	72	None	-3	54	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
		CHEMBL39	139	72	None	-3	54	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
		DB08839	139	72	None	-3	54	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
		25107516	187185	0	None	-4	3	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	433	8	0	3	5.1	CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	10.1021/jm800615e
		CHEMBL492282	187185	0	None	-4	3	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	433	8	0	3	5.1	CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	10.1021/jm800615e
		25256850	189733	0	None	44	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	364	7	1	4	3.3	O=c1[nH]c2ccccc2n1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2009.02.008
		CHEMBL515780	189733	0	None	44	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	364	7	1	4	3.3	O=c1[nH]c2ccccc2n1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2009.02.008
		10917174	102182	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	439	7	1	3	5.6	C=CCn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
		CHEMBL302766	102182	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	439	7	1	3	5.6	C=CCn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
		11397799	84733	0	None	-1	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	421	8	1	4	4.2	COc1ccccc1N1CCN(CCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
		CHEMBL222864	84733	0	None	-1	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	421	8	1	4	4.2	COc1ccccc1N1CCN(CCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
		9881600	55197	4	None	8	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1cccc(-c2ccccc2)n1	10.1016/j.bmc.2010.01.035
		CHEMBL161765	55197	4	None	8	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1cccc(-c2ccccc2)n1	10.1016/j.bmc.2010.01.035
		24963856	88345	0	None	363	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	253	4	0	1	4.1	Cc1cccc(C)c1-c1cccc(CCN(C)C)c1	10.1016/j.bmcl.2007.03.054
		CHEMBL234881	88345	0	None	363	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	253	4	0	1	4.1	Cc1cccc(C)c1-c1cccc(CCN(C)C)c1	10.1016/j.bmcl.2007.03.054
		44401164	69816	0	None	-30	9	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL193639	69816	0	None	-30	9	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		135398737	958	93	None	-7	89	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030030n
		38	958	93	None	-7	89	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030030n
		722	958	93	None	-7	89	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030030n
		CHEMBL42	958	93	None	-7	89	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030030n
		DB00363	958	93	None	-7	89	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030030n
		153287553	171104	0	None	79	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	264	1	1	2	3.7	C[C@@]12CN(c3ccccc3)c3ccccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
		CHEMBL4457754	171104	0	None	79	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	264	1	1	2	3.7	C[C@@]12CN(c3ccccc3)c3ccccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
		66800991	112068	0	None	1	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	456	7	1	8	2.4	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cnc2ccccn12	10.1021/jm401895u
		CHEMBL3289963	112068	0	None	1	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	456	7	1	8	2.4	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cnc2ccccn12	10.1021/jm401895u
		66800910	112107	0	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	437	8	1	6	4.0	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccs1	10.1021/jm401895u
		CHEMBL3290000	112107	0	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	437	8	1	6	4.0	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccs1	10.1021/jm401895u
		1621	2429	17	None	-22	45	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm0341204
		17	2429	17	None	-22	45	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm0341204
		5761	2429	17	None	-22	45	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm0341204
		CHEMBL263881	2429	17	None	-22	45	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm0341204
		DB04829	2429	17	None	-22	45	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm0341204
		11307899	78868	0	None	-100	7	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	597	6	4	6	2.5	CC(C)C[C@H]1C(=O)N[C@@H](Cc2ccccc2)[C@]2(O)O[C@@](C)(NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)C(=O)N12	10.1021/jm0341204
		CHEMBL2112882	78868	0	None	-100	7	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	597	6	4	6	2.5	CC(C)C[C@H]1C(=O)N[C@@H](Cc2ccccc2)[C@]2(O)O[C@@](C)(NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)C(=O)N12	10.1021/jm0341204
		44341114	113390	0	None	14	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	476	6	2	3	5.1	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(c2cc3ccccc3[nH]2)CC1	10.1016/s0960-894x(02)00690-x
		CHEMBL331803	113390	0	None	14	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	476	6	2	3	5.1	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(c2cc3ccccc3[nH]2)CC1	10.1016/s0960-894x(02)00690-x
		133	2496	52	None	-16	42	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/s0960-894x(00)00166-9
		1723	2496	52	None	-16	42	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/s0960-894x(00)00166-9
		28693	2496	52	None	-16	42	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/s0960-894x(00)00166-9
		CHEMBL19215	2496	52	None	-16	42	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/s0960-894x(00)00166-9
		DB13520	2496	52	None	-16	42	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/s0960-894x(00)00166-9
		CHEMBL5081379	214746	0	None	1	9	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		134133064	144735	0	None	4	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	314	5	0	3	3.0	CC1(C)CC(=O)N(CCCCN2Cc3ccccc3C2)C(=O)C1	10.1016/j.bmc.2016.09.019
		CHEMBL3908870	144735	0	None	4	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	314	5	0	3	3.0	CC1(C)CC(=O)N(CCCCN2Cc3ccccc3C2)C(=O)C1	10.1016/j.bmc.2016.09.019
		153287553	171104	0	None	79	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	264	1	1	2	3.7	C[C@@]12CN(c3ccccc3)c3ccccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
		CHEMBL4457754	171104	0	None	79	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	264	1	1	2	3.7	C[C@@]12CN(c3ccccc3)c3ccccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
		133	2496	52	None	-10	42	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/j.ejmech.2019.111705
		1723	2496	52	None	-10	42	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/j.ejmech.2019.111705
		28693	2496	52	None	-10	42	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/j.ejmech.2019.111705
		CHEMBL19215	2496	52	None	-10	42	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/j.ejmech.2019.111705
		DB13520	2496	52	None	-10	42	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/j.ejmech.2019.111705
		133	2496	52	None	-10	42	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/j.bmcl.2010.03.012
		1723	2496	52	None	-10	42	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/j.bmcl.2010.03.012
		28693	2496	52	None	-10	42	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/j.bmcl.2010.03.012
		CHEMBL19215	2496	52	None	-10	42	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/j.bmcl.2010.03.012
		DB13520	2496	52	None	-10	42	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/j.bmcl.2010.03.012
		133	2496	52	None	-10	42	Human	8.2	pKi	=	8.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1021/jm030841r
		1723	2496	52	None	-10	42	Human	8.2	pKi	=	8.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1021/jm030841r
		28693	2496	52	None	-10	42	Human	8.2	pKi	=	8.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1021/jm030841r
		CHEMBL19215	2496	52	None	-10	42	Human	8.2	pKi	=	8.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1021/jm030841r
		DB13520	2496	52	None	-10	42	Human	8.2	pKi	=	8.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1021/jm030841r
		22857296	29150	0	None	9	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	389	4	2	3	4.1	CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/jm030030n
		CHEMBL13816	29150	0	None	9	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	389	4	2	3	4.1	CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/jm030030n
		11465316	65262	0	None	26	2	Rat	8.2	pKi	=	8.2	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	369	8	0	4	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2c(OC)cccc2OC)C1	10.1016/j.bmcl.2004.11.013
		CHEMBL182792	65262	0	None	26	2	Rat	8.2	pKi	=	8.2	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	369	8	0	4	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2c(OC)cccc2OC)C1	10.1016/j.bmcl.2004.11.013
		11465316	65262	0	None	26	2	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	369	8	0	4	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2c(OC)cccc2OC)C1	10.1021/jm0498102
		CHEMBL182792	65262	0	None	26	2	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	369	8	0	4	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2c(OC)cccc2OC)C1	10.1021/jm0498102
		9799318	106535	0	None	1	4	Human	8.2	pKi	=	8.2	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	366	5	1	3	4.5	O=C1Nc2cccc3c2C1(CCCCN1CCc2sccc2C1)CCC3	10.1016/s0960-894x(02)00485-7
		CHEMBL314055	106535	0	None	1	4	Human	8.2	pKi	=	8.2	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	366	5	1	3	4.5	O=C1Nc2cccc3c2C1(CCCCN1CCc2sccc2C1)CCC3	10.1016/s0960-894x(02)00485-7
		44341126	9469	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	376	5	1	4	2.8	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3c[nH]nc3c2)CC1	10.1016/s0960-894x(02)00690-x
		CHEMBL111922	9469	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	376	5	1	4	2.8	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3c[nH]nc3c2)CC1	10.1016/s0960-894x(02)00690-x
		44340883	9666	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	376	5	1	4	2.8	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3[nH]cnc3c2)CC1	10.1016/s0960-894x(02)00690-x
		CHEMBL112876	9666	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	376	5	1	4	2.8	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3[nH]cnc3c2)CC1	10.1016/s0960-894x(02)00690-x
		10884717	204272	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	441	5	1	4	5.1	CC(=O)n1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
		CHEMBL71225	204272	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	441	5	1	4	5.1	CC(=O)n1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
		162657983	181048	0	None	-26	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	438	7	1	6	3.3	Cn1ccc2cc(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)ccc21	10.1016/j.ejmech.2020.112149
		CHEMBL4759492	181048	0	None	-26	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	438	7	1	6	3.3	Cn1ccc2cc(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)ccc21	10.1016/j.ejmech.2020.112149
		9799318	106535	0	None	-1	4	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	366	5	1	3	4.5	O=C1Nc2cccc3c2C1(CCCCN1CCc2sccc2C1)CCC3	10.1021/jm0498102
		CHEMBL314055	106535	0	None	-1	4	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	366	5	1	3	4.5	O=C1Nc2cccc3c2C1(CCCCN1CCc2sccc2C1)CCC3	10.1021/jm0498102
		134157171	153938	0	None	24	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	531	14	1	6	5.3	COCOc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccc(OC)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		CHEMBL3983496	153938	0	None	24	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	531	14	1	6	5.3	COCOc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccc(OC)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		142601329	186517	5	None	61	7	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	276	2	2	3	2.5	Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
		CHEMBL4877603	186517	5	None	61	7	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	276	2	2	3	2.5	Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
		156010865	177131	0	None	3	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	307	0	1	4	3.6	CN1CCc2cccc3c2C1Cc1cc2sc(N)nc2cc1-3	10.1016/j.bmc.2020.115578
		CHEMBL4633786	177131	0	None	3	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	307	0	1	4	3.6	CN1CCc2cccc3c2C1Cc1cc2sc(N)nc2cc1-3	10.1016/j.bmc.2020.115578
		11151899	2137	13	None	-5	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-CT from rat 5-HT7 receptor expressed in HEK293 cell membranes by radioligand binding assayDisplacement of [3H]5-CT from rat 5-HT7 receptor expressed in HEK293 cell membranes by radioligand binding assay	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1021/acs.jmedchem.7b01898
		8432	2137	13	None	-5	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-CT from rat 5-HT7 receptor expressed in HEK293 cell membranes by radioligand binding assayDisplacement of [3H]5-CT from rat 5-HT7 receptor expressed in HEK293 cell membranes by radioligand binding assay	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1021/acs.jmedchem.7b01898
		CHEMBL4205783	2137	13	None	-5	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-CT from rat 5-HT7 receptor expressed in HEK293 cell membranes by radioligand binding assayDisplacement of [3H]5-CT from rat 5-HT7 receptor expressed in HEK293 cell membranes by radioligand binding assay	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1021/acs.jmedchem.7b01898
		11186523	127511	0	None	-4	9	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1C[C@@H]2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL366164	127511	0	None	-4	9	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1C[C@@H]2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		24854269	157934	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	497	10	0	4	5.9	CCC1(CCCCN2CCN(c3ccccc3OC)CC2)C(=O)N(Cc2ccccc2)c2ccccc21	10.1021/jm070279v
		CHEMBL408451	157934	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	497	10	0	4	5.9	CCC1(CCCCN2CCN(c3ccccc3OC)CC2)C(=O)N(Cc2ccccc2)c2ccccc21	10.1021/jm070279v
		1621	2429	17	None	-22	45	Human	8.2	pKi	=	8.2	Binding	Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
		17	2429	17	None	-22	45	Human	8.2	pKi	=	8.2	Binding	Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
		5761	2429	17	None	-22	45	Human	8.2	pKi	=	8.2	Binding	Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
		CHEMBL263881	2429	17	None	-22	45	Human	8.2	pKi	=	8.2	Binding	Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
		DB04829	2429	17	None	-22	45	Human	8.2	pKi	=	8.2	Binding	Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
		90656712	110970	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	399	5	2	3	5.0	CCc1[nH]c2ccc(O)cc2c1CCN1CCN(c2cccc3ccccc23)CC1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262395	110970	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	399	5	2	3	5.0	CCc1[nH]c2ccc(O)cc2c1CCN1CCN(c2cccc3ccccc23)CC1	10.1016/j.ejmech.2014.04.034
		11432177	85122	0	None	1	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins	ChEMBL	435	9	1	4	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/acs.jmedchem.5b00982
		CHEMBL224820	85122	0	None	1	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins	ChEMBL	435	9	1	4	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/acs.jmedchem.5b00982
		44401164	69816	0	None	-30	9	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL193639	69816	0	None	-30	9	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		142601329	186517	5	None	61	7	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	276	2	2	3	2.5	Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
		CHEMBL4877603	186517	5	None	61	7	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	276	2	2	3	2.5	Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
		11432177	85122	0	None	1	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	435	9	1	4	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
		CHEMBL224820	85122	0	None	1	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	435	9	1	4	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
		54758298	66008	0	None	-4	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	401	6	1	3	4.5	O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1021/jm200547z
		CHEMBL1836857	66008	0	None	-4	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	401	6	1	3	4.5	O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1021/jm200547z
		56943599	112086	0	None	1	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	498	8	1	6	4.5	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
		CHEMBL3289980	112086	0	None	1	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	498	8	1	6	4.5	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
		CHEMBL5081379	214746	0	None	1	9	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		118728525	117720	0	None	-6	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	420	9	0	6	3.8	CCOc1ccccc1N1CCN(CCCCCn2cnc3ccccc3c2=O)CC1	10.1016/j.bmcl.2015.02.042
		CHEMBL3401488	117720	0	None	-6	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	420	9	0	6	3.8	CCOc1ccccc1N1CCN(CCCCCn2cnc3ccccc3c2=O)CC1	10.1016/j.bmcl.2015.02.042
		10562462	99692	1	None	5	3	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	247	0	0	1	3.3	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)C3	10.1021/jm9911433
		CHEMBL284586	99692	1	None	5	3	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	247	0	0	1	3.3	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)C3	10.1021/jm9911433
		76318011	105507	0	None	2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	425	5	0	4	5.6	COc1ccccc1N1CCN(Cc2cn(-c3cccc(C)c3C)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
		CHEMBL3121422	105507	0	None	2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	425	5	0	4	5.6	COc1ccccc1N1CCN(Cc2cn(-c3cccc(C)c3C)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
		60196079	81806	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	252	2	1	2	3.1	Cc1ccccc1-c1ccccc1N1CCNCC1	10.1021/jm3003679
		CHEMBL2164329	81806	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	252	2	1	2	3.1	Cc1ccccc1-c1ccccc1N1CCNCC1	10.1021/jm3003679
		24854039	95767	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	394	7	1	2	5.5	CCC1(CCCCN2CCC(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
		CHEMBL258537	95767	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	394	7	1	2	5.5	CCC1(CCCCN2CCC(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
		56943891	112051	0	None	1	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	498	8	1	6	4.5	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
		CHEMBL3289946	112051	0	None	1	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	498	8	1	6	4.5	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
		10562462	99692	1	None	5	3	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	247	0	0	1	3.3	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)C3	10.1016/s0960-894x(00)00655-7
		CHEMBL284586	99692	1	None	5	3	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	247	0	0	1	3.3	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)C3	10.1016/s0960-894x(00)00655-7
		44266160	207504	0	None	6	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	421	4	0	3	3.3	O=C1c2ccccc2CCCN1CCN1CCC(N2C(=O)Cc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
		CHEMBL9446	207504	0	None	6	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	421	4	0	3	3.3	O=C1c2ccccc2CCCN1CCN1CCC(N2C(=O)Cc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
		162661903	181428	0	None	-19	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	425	7	1	6	3.6	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2o1	10.1016/j.ejmech.2020.112149
		CHEMBL4764006	181428	0	None	-19	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	425	7	1	6	3.6	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2o1	10.1016/j.ejmech.2020.112149
		24854103	96155	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)c(Cl)cc21	10.1021/jm070279v
		CHEMBL260551	96155	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)c(Cl)cc21	10.1021/jm070279v
		44393001	64861	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	348	8	3	6	3.7	CC(Nc1nc(N)nc(NCCCc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
		CHEMBL182121	64861	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	348	8	3	6	3.7	CC(Nc1nc(N)nc(NCCCc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
		71455083	81830	0	None	-100	7	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay	ChEMBL	389	6	0	3	4.8	O=C(C1CCCCC1)N(CCN1CC=C(c2ccccc2)CC1)c1ccccn1	10.1016/j.bmcl.2012.05.119
		CHEMBL2164354	81830	0	None	-100	7	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay	ChEMBL	389	6	0	3	4.8	O=C(C1CCCCC1)N(CCN1CC=C(c2ccccc2)CC1)c1ccccn1	10.1016/j.bmcl.2012.05.119
		22857296	29150	0	None	-9	4	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	389	4	2	3	4.1	CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/jm030030n
		CHEMBL13816	29150	0	None	-9	4	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	389	4	2	3	4.1	CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/jm030030n
		11573726	71531	0	None	-7	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	343	6	1	4	1.8	O=C1C2CCCN2C(=O)N1CCCNCC1CCc2ccccc2O1	10.1021/jm2007886
		CHEMBL1926750	71531	0	None	-7	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	343	6	1	4	1.8	O=C1C2CCCN2C(=O)N1CCCNCC1CCc2ccccc2O1	10.1021/jm2007886
		CHEMBL1962912	71531	0	None	-7	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	343	6	1	4	1.8	O=C1C2CCCN2C(=O)N1CCCNCC1CCc2ccccc2O1	10.1021/jm2007886
		76328896	106272	0	None	3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	368	4	0	4	4.3	c1ccc(N2CCN(Cc3cn(-c4cccnc4)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
		CHEMBL3121432	106272	0	None	3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	368	4	0	4	4.3	c1ccc(N2CCN(Cc3cn(-c4cccnc4)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
		CHEMBL3139016	106272	0	None	3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	368	4	0	4	4.3	c1ccc(N2CCN(Cc3cn(-c4cccnc4)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
		71458647	81413	0	None	-1	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	434	9	1	4	4.0	CC(C)c1ccccc1OCCN1CCC(CNS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159457	81413	0	None	-1	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	434	9	1	4	4.0	CC(C)c1ccccc1OCCN1CCC(CNS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2012.07.043
		90644063	112035	0	None	-2	10	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	3	3.7	Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2020.115943
		CHEMBL3289648	112035	0	None	-2	10	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	3	3.7	Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2020.115943
		6918542	204924	24	None	-537	10	Human	6.2	pKi	=	6.2	Binding	Compound was evaluated for its binding affinity for human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity for human 5-hydroxytryptamine 7 receptor	ChEMBL	358	6	0	5	3.0	COc1ccc2c(c1)c(CCN(C)C)cn2S(=O)(=O)c1ccccc1	10.1016/s0960-894x(00)00453-4
		CHEMBL76237	204924	24	None	-537	10	Human	6.2	pKi	=	6.2	Binding	Compound was evaluated for its binding affinity for human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity for human 5-hydroxytryptamine 7 receptor	ChEMBL	358	6	0	5	3.0	COc1ccc2c(c1)c(CCN(C)C)cn2S(=O)(=O)c1ccccc1	10.1016/s0960-894x(00)00453-4
		156019939	177981	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	254	2	0	2	3.1	CN(C)[C@@H]1CCc2c(cccc2-c2cccn2C)C1	10.1016/j.bmc.2019.115262
		CHEMBL4646100	177981	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	254	2	0	2	3.1	CN(C)[C@@H]1CCc2c(cccc2-c2cccn2C)C1	10.1016/j.bmc.2019.115262
		11575479	94743	0	None	-7	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptorDisplacement of [3H]LSD from human cloned 5HT7 receptor	ChEMBL	425	4	1	3	5.7	CC1(c2cccc(OCc3ccccc3)c2)C(=O)Nc2cc(Cl)cc(Cl)c2C1=O	10.1016/j.bmcl.2007.11.045
		CHEMBL253096	94743	0	None	-7	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptorDisplacement of [3H]LSD from human cloned 5HT7 receptor	ChEMBL	425	4	1	3	5.7	CC1(c2cccc(OCc3ccccc3)c2)C(=O)Nc2cc(Cl)cc(Cl)c2C1=O	10.1016/j.bmcl.2007.11.045
		145978482	163631	0	None	2	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	436	8	1	4	4.2	O=S(=O)(NC1CCN(CCOc2cccc(-c3ccccc3)c2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
		CHEMBL4203872	163631	0	None	2	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	436	8	1	4	4.2	O=S(=O)(NC1CCN(CCOc2cccc(-c3ccccc3)c2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
		168284975	191485	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	404	5	0	6	3.5	COc1cc2ncnc(N3CCC(CN4CCc5ccccc5C4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
		CHEMBL5193580	191485	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	404	5	0	6	3.5	COc1cc2ncnc(N3CCC(CN4CCc5ccccc5C4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
		122483300	138090	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	384	8	0	3	6.1	CN(CCCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
		CHEMBL3765794	138090	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	384	8	0	3	6.1	CN(CCCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
		CHEMBL3765838	138090	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	384	8	0	3	6.1	CN(CCCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
		57391158	71557	0	None	10	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	444	7	1	5	3.4	O=S(=O)(NCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
		CHEMBL1949979	71557	0	None	10	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	444	7	1	5	3.4	O=S(=O)(NCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
		CHEMBL1963033	71557	0	None	10	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	444	7	1	5	3.4	O=S(=O)(NCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
		122483300	138090	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	384	8	0	3	6.1	CN(CCCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
		CHEMBL3765794	138090	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	384	8	0	3	6.1	CN(CCCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
		CHEMBL3765838	138090	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	384	8	0	3	6.1	CN(CCCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
		168277374	190369	0	None	9	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	441	8	4	6	4.6	Nc1nc(NCCc2cccc(Cl)c2Cl)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
		CHEMBL5177186	190369	0	None	9	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	441	8	4	6	4.6	Nc1nc(NCCc2cccc(Cl)c2Cl)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
		168291906	192030	0	None	-3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	452	8	0	5	4.8	O=c1n(CCCCCCN2CCN(c3cccc(Cl)c3)CC2)c2cccc3c2n1CCC3	10.1016/j.ejmech.2022.114319
		CHEMBL5201984	192030	0	None	-3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	452	8	0	5	4.8	O=c1n(CCCCCCN2CCN(c3cccc(Cl)c3)CC2)c2cccc3c2n1CCC3	10.1016/j.ejmech.2022.114319
		66803500	156439	0	None	-24	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	459	8	3	4	4.4	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(O)c1	10.1021/acs.jmedchem.7b00839
		CHEMBL4066971	156439	0	None	-24	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	459	8	3	4	4.4	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(O)c1	10.1021/acs.jmedchem.7b00839
		118736396	118950	0	None	-1	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	497	6	0	10	1.3	Cn1c(=O)c2c(nc3n(CCCCN4CCN(c5ccc(Cl)cc5)CC4)c(=O)ccn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
		CHEMBL3423378	118950	0	None	-1	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	497	6	0	10	1.3	Cn1c(=O)c2c(nc3n(CCCCN4CCN(c5ccc(Cl)cc5)CC4)c(=O)ccn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
		162642955	181739	0	None	38	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	468	9	0	4	6.1	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc(Cl)c(F)c3)CC2)cc1	10.1016/j.ejmech.2020.112395
		CHEMBL4777209	181739	0	None	38	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	468	9	0	4	6.1	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc(Cl)c(F)c3)CC2)cc1	10.1016/j.ejmech.2020.112395
		163196460	192691	3	None	-56	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	394	4	1	7	3.4	CN1CCN(c2nc(N)nc(C(C)(C)Sc3ccc4ccccc4c3)n2)CC1	10.1016/j.ejmech.2022.114645
		CHEMBL5219240	192691	3	None	-56	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	394	4	1	7	3.4	CN1CCN(c2nc(N)nc(C(C)(C)Sc3ccc4ccccc4c3)n2)CC1	10.1016/j.ejmech.2022.114645
		66801837	157528	0	None	-6	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	507	8	2	3	6.1	Cc1[nH]c2ccc(Cl)cc2c1C1=CCN(CCCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1021/acs.jmedchem.7b00839
		CHEMBL4079972	157528	0	None	-6	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	507	8	2	3	6.1	Cc1[nH]c2ccc(Cl)cc2c1C1=CCN(CCCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1021/acs.jmedchem.7b00839
		2867758	162042	7	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	339	6	1	2	5.5	Cc1ccc(C(C)(C)CC(C)NCc2ccc(C(F)(F)F)cc2)o1	10.1016/j.ejmech.2018.04.010
		CHEMBL4160177	162042	7	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	339	6	1	2	5.5	Cc1ccc(C(C)(C)CC(C)NCc2ccc(C(F)(F)F)cc2)o1	10.1016/j.ejmech.2018.04.010
		53377139	66380	0	None	-21	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	413	6	0	6	3.5	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2011.04.060
		CHEMBL1851703	66380	0	None	-21	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	413	6	0	6	3.5	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2011.04.060
		CHEMBL3216068	66380	0	None	-21	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	413	6	0	6	3.5	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2011.04.060
		134130379	142205	0	None	-5	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	402	8	0	5	3.9	O=c1cc(-c2ccccc2)ncn1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2016.12.039
		CHEMBL3884137	142205	0	None	-5	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	402	8	0	5	3.9	O=c1cc(-c2ccccc2)ncn1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2016.12.039
		155568224	176121	0	None	-4	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	350	4	1	7	2.2	CN1CCN(c2nc(N)nc(CSc3ccccc3Cl)n2)CC1	10.1016/j.ejmech.2019.06.022
		CHEMBL4591878	176121	0	None	-4	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	350	4	1	7	2.2	CN1CCN(c2nc(N)nc(CSc3ccccc3Cl)n2)CC1	10.1016/j.ejmech.2019.06.022
		122483251	138103	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.9	O=C(CCCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3764364	138103	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.9	O=C(CCCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765851	138103	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.9	O=C(CCCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		122483251	138103	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.9	O=C(CCCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3764364	138103	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.9	O=C(CCCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765851	138103	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.9	O=C(CCCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		76328894	106274	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	398	5	0	5	4.4	COc1ccccc1N1CCN(Cc2cn(-c3ccccn3)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
		CHEMBL3121431	106274	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	398	5	0	5	4.4	COc1ccccc1N1CCN(Cc2cn(-c3ccccn3)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
		CHEMBL3139018	106274	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	398	5	0	5	4.4	COc1ccccc1N1CCN(Cc2cn(-c3ccccn3)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
		164620912	185735	0	None	-7	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	341	4	1	4	2.6	OC1c2ccc(F)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
		CHEMBL4866053	185735	0	None	-7	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	341	4	1	4	2.6	OC1c2ccc(F)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
		118709755	113546	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	368	8	0	2	5.0	O=C1Cc2ccccc2N1CCCCCCCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
		CHEMBL3321797	113546	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	368	8	0	2	5.0	O=C1Cc2ccccc2N1CCCCCCCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
		135398737	958	93	None	-7	89	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2015.09.045
		38	958	93	None	-7	89	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2015.09.045
		722	958	93	None	-7	89	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2015.09.045
		CHEMBL42	958	93	None	-7	89	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2015.09.045
		DB00363	958	93	None	-7	89	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2015.09.045
		60165412	75359	0	None	-17	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	379	7	0	5	4.5	O=C(CCCCN1CCN(c2ccccc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
		CHEMBL2037530	75359	0	None	-17	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	379	7	0	5	4.5	O=C(CCCCN1CCN(c2ccccc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
		162666571	182307	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	460	10	0	6	5.2	COc1ccc(-c2ccccc2N2CCN(CC(C)(C)CCCOc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
		CHEMBL4784167	182307	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	460	10	0	6	5.2	COc1ccc(-c2ccccc2N2CCN(CC(C)(C)CCCOc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
		44582707	186998	0	None	-5	4	Human	5.2	pKi	=	5.2	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	430	10	0	6	4.1	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL490634	186998	0	None	-5	4	Human	5.2	pKi	=	5.2	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	430	10	0	6	4.1	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1	10.1016/j.bmc.2009.03.021
		155519559	170381	0	None	-3162	6	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting	ChEMBL	419	4	1	6	3.8	COc1ccc2c(c1)c(C1=CCNCC1)cn2S(=O)(=O)c1ccc2cccnc2c1	10.1021/acsmedchemlett.6b00056
		CHEMBL4447846	170381	0	None	-3162	6	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting	ChEMBL	419	4	1	6	3.8	COc1ccc2c(c1)c(C1=CCNCC1)cn2S(=O)(=O)c1ccc2cccnc2c1	10.1021/acsmedchemlett.6b00056
		71452382	83794	0	None	-199	10	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	309	4	1	3	2.0	COc1ccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1	10.1016/j.bmcl.2012.08.046
		CHEMBL2205812	83794	0	None	-199	10	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	309	4	1	3	2.0	COc1ccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1	10.1016/j.bmcl.2012.08.046
		127051516	140857	0	None	-26	7	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	420	6	1	5	4.0	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3s1)CC2	10.1016/j.bmc.2016.06.011
		CHEMBL3819567	140857	0	None	-26	7	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	420	6	1	5	4.0	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3s1)CC2	10.1016/j.bmc.2016.06.011
		164619216	185664	0	None	-74	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	424	7	1	7	3.8	CCCCC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
		CHEMBL4864863	185664	0	None	-74	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	424	7	1	7	3.8	CCCCC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
		118724645	120600	0	None	-2	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	367	5	0	7	1.3	Cn1c(=O)c2c(ncn2CCCCN2CCc3ccccc3C2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		CHEMBL3361003	120600	0	None	-2	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	367	5	0	7	1.3	Cn1c(=O)c2c(ncn2CCCCN2CCc3ccccc3C2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		CHEMBL3545907	120600	0	None	-2	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	367	5	0	7	1.3	Cn1c(=O)c2c(ncn2CCCCN2CCc3ccccc3C2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		2470	3653	50	None	-1096	59	Mouse	7.2	pKi	=	7.2	Binding	Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
		3300	3653	50	None	-1096	59	Mouse	7.2	pKi	=	7.2	Binding	Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
		5265	3653	50	None	-1096	59	Mouse	7.2	pKi	=	7.2	Binding	Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
		99	3653	50	None	-1096	59	Mouse	7.2	pKi	=	7.2	Binding	Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
		CHEMBL267930	3653	50	None	-1096	59	Mouse	7.2	pKi	=	7.2	Binding	Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
		122181345	121887	0	None	-1	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	490	8	1	5	4.2	COc1ccccc1N1CCN(CCCCN2C(=O)NC3(CCCCC3c3ccccc3)C2=O)CC1	10.1016/j.bmc.2015.04.026
		CHEMBL3590097	121887	0	None	-1	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	490	8	1	5	4.2	COc1ccccc1N1CCN(CCCCN2C(=O)NC3(CCCCC3c3ccccc3)C2=O)CC1	10.1016/j.bmc.2015.04.026
		11566574	71485	0	None	-2	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	355	6	1	4	2.0	O=C1C2CCCN2C(=O)N1C/C=C/CNCC1CCc2ccccc2O1	10.1021/jm2007886
		CHEMBL1926753	71485	0	None	-2	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	355	6	1	4	2.0	O=C1C2CCCN2C(=O)N1C/C=C/CNCC1CCc2ccccc2O1	10.1021/jm2007886
		CHEMBL1962487	71485	0	None	-2	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	355	6	1	4	2.0	O=C1C2CCCN2C(=O)N1C/C=C/CNCC1CCc2ccccc2O1	10.1021/jm2007886
		25125374	177886	0	None	2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	319	2	0	1	4.8	CN(C)C1CCc2c(cccc2-c2cccc(C(F)(F)F)c2)C1	10.1016/j.bmc.2019.115262
		CHEMBL4644725	177886	0	None	2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	319	2	0	1	4.8	CN(C)C1CCc2c(cccc2-c2cccc(C(F)(F)F)c2)C1	10.1016/j.bmc.2019.115262
		164627977	186433	0	None	-12	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	355	4	0	4	3.3	O=C1c2cc(Cl)ccc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
		CHEMBL4876297	186433	0	None	-12	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	355	4	0	4	3.3	O=C1c2cc(Cl)ccc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
		156022183	178207	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	278	2	1	2	3.8	CCCN1CCc2cccc3c2C1Cc1ccc(N)cc1-3	10.1016/j.bmc.2020.115578
		CHEMBL4649646	178207	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	278	2	1	2	3.8	CCCN1CCc2cccc3c2C1Cc1ccc(N)cc1-3	10.1016/j.bmc.2020.115578
		42626361	186779	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	363	7	0	3	3.6	O=C1Cc2ccccc2N1CCCCCN1CCN(c2ccccc2)CC1	10.1021/jm8014553
		CHEMBL489029	186779	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	363	7	0	3	3.6	O=C1Cc2ccccc2N1CCCCCN1CCN(c2ccccc2)CC1	10.1021/jm8014553
		42625353	193065	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	393	8	0	4	3.6	COc1ccccc1N1CCN(CCCCCN2C(=O)Cc3ccccc32)CC1	10.1021/jm8014553
		CHEMBL522417	193065	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	393	8	0	4	3.6	COc1ccccc1N1CCN(CCCCCN2C(=O)Cc3ccccc32)CC1	10.1021/jm8014553
		11348477	126786	0	None	-2	2	Rat	7.2	pKi	=	7.2	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	343	6	0	5	1.5	COc1ccccc1N1CCN(C/C=C/CN2C(=O)CCC2=O)CC1	10.1016/j.bmcl.2004.09.029
		CHEMBL365412	126786	0	None	-2	2	Rat	7.2	pKi	=	7.2	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	343	6	0	5	1.5	COc1ccccc1N1CCN(C/C=C/CN2C(=O)CCC2=O)CC1	10.1016/j.bmcl.2004.09.029
		10991109	205167	1	None	-6	5	Human	7.2	pKi	=	7.2	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	329	5	0	2	4.1	O=C(c1ccc(F)cc1)C1CCN(CCc2ccc(F)cc2)CC1	10.1021/jm0200411
		CHEMBL78218	205167	1	None	-6	5	Human	7.2	pKi	=	7.2	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	329	5	0	2	4.1	O=C(c1ccc(F)cc1)C1CCN(CCc2ccc(F)cc2)CC1	10.1021/jm0200411
		9979252	98517	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	415	7	0	4	4.4	COc1ccccc1N1CCN(CCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1016/s0960-894x(00)00166-9
		CHEMBL276206	98517	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	415	7	0	4	4.4	COc1ccccc1N1CCN(CCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1016/s0960-894x(00)00166-9
		10436045	3516	4	None	-19	13	Human	7.2	pKi	=	7.2	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor was determinedBinding affinity for 5-hydroxytryptamine 7 receptor was determined	ChEMBL	499	9	3	3	6.4	O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2	10.1016/s0960-894x(01)00397-3
		782	3516	4	None	-19	13	Human	7.2	pKi	=	7.2	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor was determinedBinding affinity for 5-hydroxytryptamine 7 receptor was determined	ChEMBL	499	9	3	3	6.4	O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2	10.1016/s0960-894x(01)00397-3
		CHEMBL432713	3516	4	None	-19	13	Human	7.2	pKi	=	7.2	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor was determinedBinding affinity for 5-hydroxytryptamine 7 receptor was determined	ChEMBL	499	9	3	3	6.4	O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2	10.1016/s0960-894x(01)00397-3
		49850872	56458	0	None	-251	9	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	388	5	1	4	3.9	CC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
		CHEMBL1632206	56458	0	None	-251	9	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	388	5	1	4	3.9	CC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
		90656714	110967	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay	ChEMBL	321	4	2	3	3.2	Oc1ccc2[nH]cc(CCN3CCN(c4ccccc4)CC3)c2c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262390	110967	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay	ChEMBL	321	4	2	3	3.2	Oc1ccc2[nH]cc(CCN3CCN(c4ccccc4)CC3)c2c1	10.1016/j.ejmech.2014.04.034
		37459	746	13	None	-194	25	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/s0960-894x(00)00166-9
		62	746	13	None	-194	25	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/s0960-894x(00)00166-9
		CHEMBL8514	746	13	None	-194	25	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/s0960-894x(00)00166-9
		135	2532	43	None	-50	58	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(00)00166-9
		1796	2532	43	None	-50	58	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(00)00166-9
		4184	2532	43	None	-50	58	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(00)00166-9
		CHEMBL6437	2532	43	None	-50	58	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(00)00166-9
		DB06148	2532	43	None	-50	58	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(00)00166-9
		9979252	98517	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	415	7	0	4	4.4	COc1ccccc1N1CCN(CCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1021/jm030841r
		CHEMBL276206	98517	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	415	7	0	4	4.4	COc1ccccc1N1CCN(CCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1021/jm030841r
		44268087	20194	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	374	6	0	3	4.0	CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm970519e
		CHEMBL13049	20194	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	374	6	0	3	4.0	CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm970519e
		44268087	20194	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1016/s0960-894x(00)00166-9
		CHEMBL13049	20194	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1016/s0960-894x(00)00166-9
		117209912	185337	1	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
		CHEMBL4859827	185337	1	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
		164627977	186433	0	None	-12	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	355	4	0	4	3.3	O=C1c2cc(Cl)ccc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
		CHEMBL4876297	186433	0	None	-12	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	355	4	0	4	3.3	O=C1c2cc(Cl)ccc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
		CHEMBL5077178	214487	0	None	-4	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1ccc(F)cc1	10.1021/acs.jmedchem.1c00497
		90644063	112035	0	None	-2	10	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	3	3.7	Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2020.115943
		CHEMBL3289648	112035	0	None	-2	10	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	3	3.7	Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2020.115943
		90656714	110967	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	321	4	2	3	3.2	Oc1ccc2[nH]cc(CCN3CCN(c4ccccc4)CC3)c2c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262390	110967	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	321	4	2	3	3.2	Oc1ccc2[nH]cc(CCN3CCN(c4ccccc4)CC3)c2c1	10.1016/j.ejmech.2014.04.034
		242	470	124	None	-15	51	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
		34	470	124	None	-15	51	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
		60795	470	124	None	-15	51	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
		CHEMBL1112	470	124	None	-15	51	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
		DB01238	470	124	None	-15	51	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
		2337	3256	77	None	-28	62	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
		50	3256	77	None	-28	62	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
		5002	3256	77	None	-28	62	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
		CHEMBL716	3256	77	None	-28	62	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
		DB01224	3256	77	None	-28	62	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
		9887537	84345	43	None	-79	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	405	4	0	5	4.0	Fc1ccc(-c2cncc(CN3CCN(c4cccc5c4OCCO5)CC3)c2)cc1	10.1021/jm070516u
		CHEMBL221692	84345	43	None	-79	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	405	4	0	5	4.0	Fc1ccc(-c2cncc(CN3CCN(c4cccc5c4OCCO5)CC3)c2)cc1	10.1021/jm070516u
		CHEMBL4751170	84345	43	None	-79	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	405	4	0	5	4.0	Fc1ccc(-c2cncc(CN3CCN(c4cccc5c4OCCO5)CC3)c2)cc1	10.1021/jm070516u
		135	2532	43	None	-83	58	Human	7.2	pKi	=	7.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030841r
		1796	2532	43	None	-83	58	Human	7.2	pKi	=	7.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030841r
		4184	2532	43	None	-83	58	Human	7.2	pKi	=	7.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030841r
		CHEMBL6437	2532	43	None	-83	58	Human	7.2	pKi	=	7.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030841r
		DB06148	2532	43	None	-83	58	Human	7.2	pKi	=	7.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030841r
		37461	17134	14	None	-70	8	Human	7.2	pKi	=	7.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	361	0	1	2	4.8	CC(C)(C)[C@@]1(O)CCN2C[C@@H]3c4ccccc4CCc4cccc(c43)[C@H]2C1	10.1021/jm030841r
		CHEMBL1255588	17134	14	None	-70	8	Human	7.2	pKi	=	7.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	361	0	1	2	4.8	CC(C)(C)[C@@]1(O)CCN2C[C@@H]3c4ccccc4CCc4cccc(c43)[C@H]2C1	10.1021/jm030841r
		90656688	110987	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	338	7	2	4	2.4	NC(=O)c1cccc(NCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262420	110987	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	338	7	2	4	2.4	NC(=O)c1cccc(NCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
		11329254	85216	0	None	2	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	450	9	1	5	4.5	O=C(CCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1)NC1CCCc2ccccc21	10.1021/jm049702f
		CHEMBL225571	85216	0	None	2	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	450	9	1	5	4.5	O=C(CCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1)NC1CCCc2ccccc21	10.1021/jm049702f
		17053	202047	7	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	244	4	1	2	2.8	COc1ccc2[nH]cc(CCN3CCCC3)c2c1	10.1021/jm030826m
		CHEMBL608537	202047	7	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	244	4	1	2	2.8	COc1ccc2[nH]cc(CCN3CCCC3)c2c1	10.1021/jm030826m
		11485965	45841	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	385	6	0	3	4.4	O=C1c2cccc3cccc(c23)N1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm030841r
		CHEMBL153132	45841	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	385	6	0	3	4.4	O=C1c2cccc3cccc(c23)N1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm030841r
		11793826	18052	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	374	6	0	3	4.0	C[C@H]1CCCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm970519e
		CHEMBL12654	18052	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	374	6	0	3	4.0	C[C@H]1CCCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm970519e
		11793826	18052	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	C[C@H]1CCCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1016/s0960-894x(00)00166-9
		CHEMBL12654	18052	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	C[C@H]1CCCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1016/s0960-894x(00)00166-9
		44368384	44406	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	373	6	0	3	4.8	CC([C@H](C)CCN1CCC[C@H](C)C1)S(=O)(=O)c1cccc2ccccc12	10.1021/jm030841r
		CHEMBL151858	44406	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	373	6	0	3	4.8	CC([C@H](C)CCN1CCC[C@H](C)C1)S(=O)(=O)c1cccc2ccccc12	10.1021/jm030841r
		127051516	140857	0	None	-26	7	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	420	6	1	5	4.0	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3s1)CC2	10.1016/j.bmc.2016.06.011
		CHEMBL3819567	140857	0	None	-26	7	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	420	6	1	5	4.0	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3s1)CC2	10.1016/j.bmc.2016.06.011
		9935387	99442	0	None	-794	14	Human	6.2	pKi	=	6.2	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand	ChEMBL	491	5	1	6	5.0	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@@H]2C1	10.1016/s0960-894x(02)00172-5
		CHEMBL282971	99442	0	None	-794	14	Human	6.2	pKi	=	6.2	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand	ChEMBL	491	5	1	6	5.0	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@@H]2C1	10.1016/s0960-894x(02)00172-5
		90654693	110079	0	None	-2	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	388	8	1	5	1.5	COc1ccccc1N1CCN(CCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235730	110079	0	None	-2	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	388	8	1	5	1.5	COc1ccccc1N1CCN(CCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
		156010396	177127	0	None	1	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	392	5	1	4	4.2	COc1cc2c3c(c1OCC1CC1)-c1cc(NC(C)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
		CHEMBL4633765	177127	0	None	1	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	392	5	1	4	4.2	COc1cc2c3c(c1OCC1CC1)-c1cc(NC(C)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
		71457264	82621	0	None	-20	6	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	447	5	1	6	4.4	COc1ccc(S(=O)(=O)n2cc(C)c3cc(Cl)ccc32)cc1NC1CCN(C)CC1	10.1021/jm300955x
		CHEMBL2179217	82621	0	None	-20	6	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	447	5	1	6	4.4	COc1ccc(S(=O)(=O)n2cc(C)c3cc(Cl)ccc32)cc1NC1CCN(C)CC1	10.1021/jm300955x
		2136365	117927	21	None	-5	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	404	3	0	5	4.5	Cc1ccc(S(=O)(=O)c2nc(N3CCc4ccccc4C3)sc2Cl)cc1	10.1016/j.bmcl.2015.03.049
		CHEMBL3403331	117927	21	None	-5	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	404	3	0	5	4.5	Cc1ccc(S(=O)(=O)c2nc(N3CCc4ccccc4C3)sc2Cl)cc1	10.1016/j.bmcl.2015.03.049
		CHEMBL5090884	215577	0	None	1	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		CHEMBL5096072	215577	0	None	1	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		11610908	68043	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	394	7	1	3	4.0	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1ccc2ccccc2c1	10.1016/j.bmc.2011.09.044
		CHEMBL1914488	68043	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	394	7	1	3	4.0	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1ccc2ccccc2c1	10.1016/j.bmc.2011.09.044
		145977467	163991	0	None	9	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	486	7	1	4	3.1	O=S(=O)(NC1CCN(CCOc2ccccc2I)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
		CHEMBL4208185	163991	0	None	9	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	486	7	1	4	3.1	O=S(=O)(NC1CCN(CCOc2ccccc2I)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
		117209912	185337	1	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
		CHEMBL4859827	185337	1	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
		11432453	85197	0	None	1	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	451	9	1	5	4.2	COc1ccccc1N1CCN(CCCCC(=O)NC2CCCc3cccc(OC)c32)CC1	10.1021/jm049702f
		CHEMBL225441	85197	0	None	1	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	451	9	1	5	4.2	COc1ccccc1N1CCN(CCCCC(=O)NC2CCCc3cccc(OC)c32)CC1	10.1021/jm049702f
		76324975	105015	0	None	8	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	473	11	1	6	4.2	COc1ccc(CNC(=O)CCCCCN2CCN(c3cccnc3-c3ccncc3)CC2)cc1	10.1016/j.bmc.2014.01.016
		CHEMBL3113604	105015	0	None	8	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	473	11	1	6	4.2	COc1ccc(CNC(=O)CCCCCN2CCN(c3cccnc3-c3ccncc3)CC2)cc1	10.1016/j.bmc.2014.01.016
		72549768	114073	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	443	9	1	4	4.6	COc1ccccc1N1CCN(CCCC(=O)NCc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2014.07.026
		CHEMBL3326977	114073	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	443	9	1	4	4.6	COc1ccccc1N1CCN(CCCC(=O)NCc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2014.07.026
		CHEMBL5090884	215577	0	None	1	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		CHEMBL5096072	215577	0	None	1	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		162644013	181839	0	None	-16	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	473	7	1	6	4.5	Cc1c(S(=O)(=O)N[C@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(F)cc12	10.1016/j.ejmech.2020.112149
		CHEMBL4778418	181839	0	None	-16	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	473	7	1	6	4.5	Cc1c(S(=O)(=O)N[C@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(F)cc12	10.1016/j.ejmech.2020.112149
		162666577	182333	0	None	-47	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	455	7	1	6	4.3	Cc1ccc2sc(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)cc2c1	10.1016/j.ejmech.2020.112149
		CHEMBL4784414	182333	0	None	-47	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	455	7	1	6	4.3	Cc1ccc2sc(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)cc2c1	10.1016/j.ejmech.2020.112149
		155562519	175212	0	None	-131	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	516	8	2	4	5.3	COc1ccc2[nH]cc(C3CC(=O)N(CCCCN4CCC(c5c[nH]c6ccc(F)cc56)CC4)C3=O)c2c1	10.1016/j.ejmech.2019.111736
		CHEMBL4571321	175212	0	None	-131	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	516	8	2	4	5.3	COc1ccc2[nH]cc(C3CC(=O)N(CCCCN4CCC(c5c[nH]c6ccc(F)cc56)CC4)C3=O)c2c1	10.1016/j.ejmech.2019.111736
		155541072	172964	0	None	1	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	290	3	2	4	1.7	CCn1cncc1-c1c[nH]c2ccc(S(N)(=O)=O)cc12	10.1039/C8MD00313K
		CHEMBL4517552	172964	0	None	1	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	290	3	2	4	1.7	CCn1cncc1-c1c[nH]c2ccc(S(N)(=O)=O)cc12	10.1039/C8MD00313K
		134134279	143654	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	257	5	1	3	3.1	CNCc1ccc(OC)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
		CHEMBL3899934	143654	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	257	5	1	3	3.1	CNCc1ccc(OC)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
		76332575	106276	0	None	-4	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	314	4	0	2	4.9	CN(C)CCc1cn(-c2cccc3ccccc23)c2ccccc12	10.1016/j.ejmech.2014.01.055
		CHEMBL3121416	106276	0	None	-4	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	314	4	0	2	4.9	CN(C)CCc1cn(-c2cccc3ccccc23)c2ccccc12	10.1016/j.ejmech.2014.01.055
		CHEMBL3139020	106276	0	None	-4	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	314	4	0	2	4.9	CN(C)CCc1cn(-c2cccc3ccccc23)c2ccccc12	10.1016/j.ejmech.2014.01.055
		44268087	20194	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	374	6	0	3	4.0	CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm030030n
		CHEMBL13049	20194	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	374	6	0	3	4.0	CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm030030n
		76328898	106416	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	381	4	0	3	5.3	Cc1cccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)c1	10.1016/j.ejmech.2014.01.055
		CHEMBL3121440	106416	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	381	4	0	3	5.3	Cc1cccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)c1	10.1016/j.ejmech.2014.01.055
		CHEMBL3139518	106416	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	381	4	0	3	5.3	Cc1cccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)c1	10.1016/j.ejmech.2014.01.055
		145983144	165880	0	None	-5	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	1	4	5.7	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4249426	165880	0	None	-5	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	1	4	5.7	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1	10.1016/j.ejmech.2018.01.002
		134154387	152460	0	None	1	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	289	3	0	1	4.5	C1=C(CCN2CCc3ccccc3C2)CCc2ccccc21	10.1016/j.bmc.2016.09.019
		CHEMBL3970994	152460	0	None	1	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	289	3	0	1	4.5	C1=C(CCN2CCc3ccccc3C2)CCc2ccccc21	10.1016/j.bmc.2016.09.019
		56944863	156719	0	None	-64	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	477	8	2	3	5.3	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(Cl)c1	10.1021/acs.jmedchem.7b00839
		CHEMBL4070254	156719	0	None	-64	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	477	8	2	3	5.3	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(Cl)c1	10.1021/acs.jmedchem.7b00839
		155540635	172530	0	None	5	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	431	7	1	4	5.4	O=c1[nH]c(CCCCN2CCC(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
		CHEMBL4483687	172530	0	None	5	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	431	7	1	4	5.4	O=c1[nH]c(CCCCN2CCC(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
		11431530	84625	0	None	1	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	405	8	1	3	4.6	O=C(CCCCCN1CCN(c2ccccc2)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
		CHEMBL222188	84625	0	None	1	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	405	8	1	3	4.6	O=C(CCCCCN1CCN(c2ccccc2)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
		168269921	190080	0	None	-218	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	430	8	0	7	3.4	O=c1n(CCCCCCN2CCN(c3cccc4cccnc34)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
		CHEMBL5172673	190080	0	None	-218	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	430	8	0	7	3.4	O=c1n(CCCCCCN2CCN(c3cccc4cccnc34)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
		21527771	70156	1	None	-263	10	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	363	6	1	3	4.2	OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
		CHEMBL1940404	70156	1	None	-263	10	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	363	6	1	3	4.2	OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
		71602687	89684	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	376	5	0	3	4.8	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2F)CC1	10.1016/j.bmc.2013.02.038
		CHEMBL2376456	89684	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	376	5	0	3	4.8	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2F)CC1	10.1016/j.bmc.2013.02.038
		56850656	71498	0	None	-27	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	371	7	1	4	2.6	O=C1C2CCCCN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
		CHEMBL1926744	71498	0	None	-27	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	371	7	1	4	2.6	O=C1C2CCCCN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
		CHEMBL1962584	71498	0	None	-27	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	371	7	1	4	2.6	O=C1C2CCCCN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
		118626088	165401	0	None	-13	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	7	3.4	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4238124	165401	0	None	-13	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	7	3.4	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/j.ejmech.2018.01.002
		134154387	152460	0	None	1	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	289	3	0	1	4.5	C1=C(CCN2CCc3ccccc3C2)CCc2ccccc21	10.1016/j.bmc.2016.09.019
		CHEMBL3970994	152460	0	None	1	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	289	3	0	1	4.5	C1=C(CCN2CCc3ccccc3C2)CCc2ccccc21	10.1016/j.bmc.2016.09.019
		72548349	114087	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	471	10	1	4	5.3	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccc(C)cc2)CC1	10.1016/j.bmc.2014.07.026
		CHEMBL3326991	114087	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	471	10	1	4	5.3	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccc(C)cc2)CC1	10.1016/j.bmc.2014.07.026
		76284725	105013	0	None	14	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	462	10	1	6	3.7	O=C(CCCCCN1CCN(c2cccnc2-c2ccncc2)CC1)NCc1ccc(F)nc1	10.1016/j.bmc.2014.01.016
		CHEMBL3113602	105013	0	None	14	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	462	10	1	6	3.7	O=C(CCCCCN1CCN(c2cccnc2-c2ccncc2)CC1)NCc1ccc(F)nc1	10.1016/j.bmc.2014.01.016
		168295509	192514	0	None	-5	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	449	6	1	8	3.0	COc1cc2ncnc(N3CCC(CN4CCN(c5ccccc5O)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
		CHEMBL5209283	192514	0	None	-5	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	449	6	1	8	3.0	COc1cc2ncnc(N3CCC(CN4CCN(c5ccccc5O)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
		71602687	89684	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	376	5	0	3	4.8	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2F)CC1	10.1016/j.bmc.2013.02.038
		CHEMBL2376456	89684	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	376	5	0	3	4.8	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2F)CC1	10.1016/j.bmc.2013.02.038
		53323534	57023	0	None	-	1	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	322	3	1	2	4.5	Clc1cccc(Cn2cc(-c3ccccc3)c3c2CCNC3)c1	10.1016/j.bmcl.2010.11.078
		CHEMBL1644485	57023	0	None	-	1	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	322	3	1	2	4.5	Clc1cccc(Cn2cc(-c3ccccc3)c3c2CCNC3)c1	10.1016/j.bmcl.2010.11.078
		46205042	124577	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	309	5	1	3	3.9	Cc1ccccc1-c1ccc(OC2CCC2)c(OC2CNC2)c1	nan
		CHEMBL3640583	124577	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	309	5	1	3	3.9	Cc1ccccc1-c1ccc(OC2CCC2)c(OC2CNC2)c1	nan
		46205042	124577	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	309	5	1	3	3.9	Cc1ccccc1-c1ccc(OC2CCC2)c(OC2CNC2)c1	nan
		CHEMBL3640583	124577	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	309	5	1	3	3.9	Cc1ccccc1-c1ccc(OC2CCC2)c(OC2CNC2)c1	nan
		155515942	170009	0	None	-331	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting	ChEMBL	389	3	1	5	3.8	O=S(=O)(c1ccc2ncccc2c1)n1cc(C2=CCNCC2)c2ccccc21	10.1021/acsmedchemlett.6b00056
		CHEMBL4442456	170009	0	None	-331	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting	ChEMBL	389	3	1	5	3.8	O=S(=O)(c1ccc2ncccc2c1)n1cc(C2=CCNCC2)c2ccccc21	10.1021/acsmedchemlett.6b00056
		46233382	200683	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	271	6	0	3	3.3	COc1ccccc1-c1ccccc1OCCN(C)C	10.1016/j.bmc.2010.01.035
		CHEMBL599819	200683	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	271	6	0	3	3.3	COc1ccccc1-c1ccccc1OCCN(C)C	10.1016/j.bmc.2010.01.035
		46204425	124565	1	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	239	3	1	2	3.0	Cc1ccccc1-c1cccc(OC2CNC2)c1	nan
		CHEMBL3640572	124565	1	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	239	3	1	2	3.0	Cc1ccccc1-c1cccc(OC2CNC2)c1	nan
		46204425	124565	1	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	239	3	1	2	3.0	Cc1ccccc1-c1cccc(OC2CNC2)c1	nan
		CHEMBL3640572	124565	1	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	239	3	1	2	3.0	Cc1ccccc1-c1cccc(OC2CNC2)c1	nan
		122181335	121877	0	None	-11	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	486	6	1	4	4.0	O=C1NC2(CCc3ccccc32)C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2015.04.026
		CHEMBL3590087	121877	0	None	-11	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	486	6	1	4	4.0	O=C1NC2(CCc3ccccc32)C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2015.04.026
		145976408	163878	0	None	10	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	424	5	1	4	3.4	O=C1Nc2ccccc2C12CCN(CCCN1CCN(c3ccc(Cl)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
		CHEMBL4206881	163878	0	None	10	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	424	5	1	4	3.4	O=C1Nc2ccccc2C12CCN(CCCN1CCN(c3ccc(Cl)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
		145964621	164337	0	None	18	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	516	7	1	4	4.0	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1cccc(Br)c1	10.1021/acs.jmedchem.8b00828
		CHEMBL4212539	164337	0	None	18	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	516	7	1	4	4.0	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1cccc(Br)c1	10.1021/acs.jmedchem.8b00828
		134154680	154562	0	None	-9	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	416	7	0	5	5.3	COc1cc2c(cc1OC)CN(CCCCc1nc3cc(Cl)ccc3s1)CC2	10.1016/j.bmc.2016.09.019
		CHEMBL3959919	154562	0	None	-9	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	416	7	0	5	5.3	COc1cc2c(cc1OC)CN(CCCCc1nc3cc(Cl)ccc3s1)CC2	10.1016/j.bmc.2016.09.019
		CHEMBL3991166	154562	0	None	-9	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	416	7	0	5	5.3	COc1cc2c(cc1OC)CN(CCCCc1nc3cc(Cl)ccc3s1)CC2	10.1016/j.bmc.2016.09.019
		156022234	178210	0	None	5	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	380	5	1	4	4.2	CCCC(=O)Nc1ccc2c(c1)-c1c(OC)c(OC)cc3c1C(C2)N(C)CC3	10.1016/j.bmc.2020.115578
		CHEMBL4649697	178210	0	None	5	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	380	5	1	4	4.2	CCCC(=O)Nc1ccc2c(c1)-c1c(OC)c(OC)cc3c1C(C2)N(C)CC3	10.1016/j.bmc.2020.115578
		181743	178572	5	None	-33	22	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	339	2	0	5	3.2	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4	10.1016/j.bmcl.2009.11.053
		CHEMBL467094	178572	5	None	-33	22	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	339	2	0	5	3.2	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4	10.1016/j.bmcl.2009.11.053
		56944086	112082	0	None	-12	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	420	8	1	7	2.8	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cccs1	10.1021/jm401895u
		CHEMBL3289976	112082	0	None	-12	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	420	8	1	7	2.8	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cccs1	10.1021/jm401895u
		134154680	154562	0	None	-9	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	416	7	0	5	5.3	COc1cc2c(cc1OC)CN(CCCCc1nc3cc(Cl)ccc3s1)CC2	10.1016/j.bmc.2016.09.019
		CHEMBL3959919	154562	0	None	-9	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	416	7	0	5	5.3	COc1cc2c(cc1OC)CN(CCCCc1nc3cc(Cl)ccc3s1)CC2	10.1016/j.bmc.2016.09.019
		CHEMBL3991166	154562	0	None	-9	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	416	7	0	5	5.3	COc1cc2c(cc1OC)CN(CCCCc1nc3cc(Cl)ccc3s1)CC2	10.1016/j.bmc.2016.09.019
		CHEMBL5082267	214795	0	None	-22	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1cccc(C(F)(F)F)c1	10.1021/acs.jmedchem.1c00497
		145984807	165776	0	None	-134	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	1	7	3.0	O=c1[nH]c2c(N3CCN(CC[C@@H]4CCCN4S(=O)(=O)c4cncc5ccccc45)CC3)cccc2o1	10.1016/j.ejmech.2018.01.002
		CHEMBL4247275	165776	0	None	-134	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	1	7	3.0	O=c1[nH]c2c(N3CCN(CC[C@@H]4CCCN4S(=O)(=O)c4cncc5ccccc45)CC3)cccc2o1	10.1016/j.ejmech.2018.01.002
		122483230	138088	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	9	0	3	5.7	CCCCN(C)CCCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765223	138088	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	9	0	3	5.7	CCCCN(C)CCCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765836	138088	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	9	0	3	5.7	CCCCN(C)CCCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		10150497	4074	47	None	-331	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	380	4	1	7	2.7	NCCc1cn(c2c1cccc2)S(=O)(=O)c1c(Cl)nc2n1ccs2	10.1021/jm070521y
		3240	4074	47	None	-331	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	380	4	1	7	2.7	NCCc1cn(c2c1cccc2)S(=O)(=O)c1c(Cl)nc2n1ccs2	10.1021/jm070521y
		CHEMBL392760	4074	47	None	-331	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	380	4	1	7	2.7	NCCc1cn(c2c1cccc2)S(=O)(=O)c1c(Cl)nc2n1ccs2	10.1021/jm070521y
		11494176	71519	0	None	-1	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	357	7	1	4	2.2	O=C1C2CCCN2C(=O)N1CCCCNC[C@@H]1CCc2ccccc2O1	10.1021/jm2007886
		CHEMBL1926735	71519	0	None	-1	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	357	7	1	4	2.2	O=C1C2CCCN2C(=O)N1CCCCNC[C@@H]1CCc2ccccc2O1	10.1021/jm2007886
		CHEMBL1962803	71519	0	None	-1	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	357	7	1	4	2.2	O=C1C2CCCN2C(=O)N1CCCCNC[C@@H]1CCc2ccccc2O1	10.1021/jm2007886
		127041261	136998	0	None	4	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	448	7	0	4	4.3	CN(C1CCN(CCOc2ccccc2C(C)(C)C)CC1)S(=O)(=O)c1cccc(F)c1	10.1016/j.bmc.2015.11.041
		CHEMBL3745975	136998	0	None	4	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	448	7	0	4	4.3	CN(C1CCN(CCOc2ccccc2C(C)(C)C)CC1)S(=O)(=O)c1cccc(F)c1	10.1016/j.bmc.2015.11.041
		57391622	71567	0	None	11	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cncc2ccccc12	10.1016/j.bmc.2011.12.039
		CHEMBL1949970	71567	0	None	11	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cncc2ccccc12	10.1016/j.bmc.2011.12.039
		CHEMBL1963100	71567	0	None	11	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cncc2ccccc12	10.1016/j.bmc.2011.12.039
		42625181	193167	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	403	7	1	4	3.4	O=C1Cc2ccccc2N1CCCCCN1CCN(c2cccc3[nH]cnc23)CC1	10.1021/jm8014553
		CHEMBL523121	193167	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	403	7	1	4	3.4	O=C1Cc2ccccc2N1CCCCCN1CCN(c2cccc3[nH]cnc23)CC1	10.1021/jm8014553
		118728513	117708	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	444	7	1	5	4.8	Cc1sc2nc(CCCCCN3CCN(c4cccc(Cl)c4)CC3)[nH]c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
		CHEMBL3401476	117708	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	444	7	1	5	4.8	Cc1sc2nc(CCCCCN3CCN(c4cccc(Cl)c4)CC3)[nH]c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
		44424660	85775	0	None	-5	2	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	454	9	0	9	1.8	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2007.05.017
		CHEMBL229311	85775	0	None	-5	2	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	454	9	0	9	1.8	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2007.05.017
		122483230	138088	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	9	0	3	5.7	CCCCN(C)CCCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765223	138088	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	9	0	3	5.7	CCCCN(C)CCCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765836	138088	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	9	0	3	5.7	CCCCN(C)CCCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		44374226	54554	1	None	-	1	Human	5.2	pKi	=	5.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	188	4	0	4	1.8	CN(C)CCSc1nccs1	10.1016/j.bmcl.2003.11.050
		CHEMBL161031	54554	1	None	-	1	Human	5.2	pKi	=	5.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	188	4	0	4	1.8	CN(C)CCSc1nccs1	10.1016/j.bmcl.2003.11.050
		11101259	51583	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	392	8	2	5	3.8	O=C(CCCCCN1CCN(c2nc3ccccc3[nH]2)CC1)c1ccccc1O	10.1021/jm020994z
		CHEMBL158332	51583	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	392	8	2	5	3.8	O=C(CCCCCN1CCN(c2nc3ccccc3[nH]2)CC1)c1ccccc1O	10.1021/jm020994z
		71452383	83796	0	None	-3	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	339	5	1	4	2.0	COc1ccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC	10.1016/j.bmcl.2012.08.046
		CHEMBL2205814	83796	0	None	-3	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	339	5	1	4	2.0	COc1ccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC	10.1016/j.bmcl.2012.08.046
		145983751	165505	0	None	-13	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	521	6	0	7	4.6	O=S(=O)(c1ccnc2ccccc12)N1CCCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4240642	165505	0	None	-13	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	521	6	0	7	4.6	O=S(=O)(c1ccnc2ccccc12)N1CCCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
		66801537	157932	0	None	-3	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	465	6	2	3	5.0	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
		CHEMBL4084492	157932	0	None	-3	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	465	6	2	3	5.0	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
		57400281	71552	0	None	-1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccc2ncccc2c1	10.1016/j.bmc.2011.12.039
		CHEMBL1949965	71552	0	None	-1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccc2ncccc2c1	10.1016/j.bmc.2011.12.039
		CHEMBL1963028	71552	0	None	-1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccc2ncccc2c1	10.1016/j.bmc.2011.12.039
		122178698	121365	0	None	1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	369	5	0	5	3.9	CCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
		CHEMBL3581244	121365	0	None	1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	369	5	0	5	3.9	CCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
		42625183	187000	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	397	5	0	3	4.1	O=C1Cc2ccccc2N1C/C=C/CN1CCN(c2cccc3ccccc23)CC1	10.1021/jm8014553
		CHEMBL490645	187000	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	397	5	0	3	4.1	O=C1Cc2ccccc2N1C/C=C/CN1CCN(c2cccc3ccccc23)CC1	10.1021/jm8014553
		42625446	188858	0	None	-4	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	413	7	0	3	4.7	O=C1Cc2ccccc2N1CCCCCN1CCN(c2cccc3ccccc23)CC1	10.1021/jm8014553
		CHEMBL506875	188858	0	None	-4	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	413	7	0	3	4.7	O=C1Cc2ccccc2N1CCCCCN1CCN(c2cccc3ccccc23)CC1	10.1021/jm8014553
		24771120	184100	0	None	-3019	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	434	4	2	6	3.4	O=C(Nc1ccc2cnn(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCNCC1	10.1016/j.bmcl.2009.03.071
		CHEMBL482562	184100	0	None	-3019	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	434	4	2	6	3.4	O=C(Nc1ccc2cnn(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCNCC1	10.1016/j.bmcl.2009.03.071
		134150597	152065	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	339	4	0	4	4.3	COc1ccccc1-c1cc(CN2CCC(C)CC2)cc2c1OCO2	10.1016/j.ejmech.2016.07.029
		CHEMBL3967387	152065	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	339	4	0	4	4.3	COc1ccccc1-c1cc(CN2CCC(C)CC2)cc2c1OCO2	10.1016/j.ejmech.2016.07.029
		118736372	118944	0	None	-11	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	497	7	0	9	2.6	Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2015.04.046
		CHEMBL3423336	118944	0	None	-11	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	497	7	0	9	2.6	Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2015.04.046
		153061504	172810	0	None	-34	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2c(ccc3ccccc23)OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
		CHEMBL4513930	172810	0	None	-34	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2c(ccc3ccccc23)OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
		155533028	171796	0	None	-1	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	458	9	0	5	5.1	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1	10.1016/j.bmcl.2019.06.029
		CHEMBL4468036	171796	0	None	-1	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	458	9	0	5	5.1	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1	10.1016/j.bmcl.2019.06.029
		CHEMBL4520788	213975	10	None	-32	25	Human	6.2	pKi	=	6.2	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a HTR7Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a HTR7	ChEMBL		None	None	None		CNCc1ccccc1-c1csc([C@H](C)Nc2nc(C)nc3cc(OC)c(OC)cc23)c1	10.6019/CHEMBL5212743
		10090247	205570	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	365	3	0	3	4.2	FC(F)(F)c1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1021/jm030030n
		CHEMBL81276	205570	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	365	3	0	3	4.2	FC(F)(F)c1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1021/jm030030n
		10090247	205570	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	365	3	0	3	4.2	FC(F)(F)c1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1016/s0960-894x(02)00438-9
		CHEMBL81276	205570	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	365	3	0	3	4.2	FC(F)(F)c1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1016/s0960-894x(02)00438-9
		127026753	137725	0	None	6	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	392	8	1	4	3.0	CC(C)c1ccccc1OCCN1CC(NS(=O)(=O)c2ccc(F)cc2)C1	10.1016/j.ejmech.2015.11.040
		CHEMBL3758978	137725	0	None	6	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	392	8	1	4	3.0	CC(C)c1ccccc1OCCN1CC(NS(=O)(=O)c2ccc(F)cc2)C1	10.1016/j.ejmech.2015.11.040
		127042185	137067	0	None	4	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	454	8	0	6	3.3	CN(C1CCN(CCOc2ccccc2-c2ccccc2)CC1)S(=O)(=O)c1cnn(C)c1	10.1016/j.bmc.2015.11.041
		CHEMBL3747003	137067	0	None	4	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	454	8	0	6	3.3	CN(C1CCN(CCOc2ccccc2-c2ccccc2)CC1)S(=O)(=O)c1cnn(C)c1	10.1016/j.bmc.2015.11.041
		145985533	165732	0	None	-7	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4246202	165732	0	None	-7	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
		145983139	165864	0	None	-1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	491	6	0	7	3.7	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4249179	165864	0	None	-1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	491	6	0	7	3.7	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
		71449629	81374	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	8	1	5	4.0	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(Cl)s2)C1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159321	81374	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	8	1	5	4.0	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(Cl)s2)C1	10.1016/j.ejmech.2012.07.043
		71455000	81423	0	None	8	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	472	8	1	4	4.5	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159466	81423	0	None	8	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	472	8	1	4	4.5	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2012.07.043
		71449643	81438	0	None	3	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	458	8	1	4	4.1	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159481	81438	0	None	3	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	458	8	1	4	4.1	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2012.07.043
		145947300	167663	0	None	19	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	511	6	2	6	2.3	CC1(c2ccc(Br)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2018.01.093
		CHEMBL4170613	167663	0	None	19	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	511	6	2	6	2.3	CC1(c2ccc(Br)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2018.01.093
		CHEMBL4301924	167663	0	None	19	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	511	6	2	6	2.3	CC1(c2ccc(Br)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2018.01.093
		156011936	177402	0	None	-1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	435	8	1	6	4.3	O=c1[nH]c2ccccc2n1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
		CHEMBL4638308	177402	0	None	-1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	435	8	1	6	4.3	O=c1[nH]c2ccccc2n1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
		156019026	177796	0	None	-1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	436	8	0	7	4.6	O=c1oc2ccccc2n1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
		CHEMBL4643450	177796	0	None	-1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	436	8	0	7	4.6	O=c1oc2ccccc2n1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
		60195996	81814	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	283	3	1	4	2.7	O=[N+]([O-])c1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
		CHEMBL2164338	81814	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	283	3	1	4	2.7	O=[N+]([O-])c1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
		71455000	81423	0	None	8	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	472	8	1	4	4.5	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)c(F)c1	10.1039/C5MD00166H
		CHEMBL2159466	81423	0	None	8	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	472	8	1	4	4.5	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)c(F)c1	10.1039/C5MD00166H
		127038033	136606	0	None	14	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	453	8	1	5	4.2	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc3ncccc23)CC1	10.1039/C5MD00166H
		CHEMBL3739680	136606	0	None	14	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	453	8	1	5	4.2	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc3ncccc23)CC1	10.1039/C5MD00166H
		127039756	136728	0	None	25	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	472	8	1	4	4.5	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cc(F)ccc1F	10.1039/C5MD00166H
		CHEMBL3740801	136728	0	None	25	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	472	8	1	4	4.5	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cc(F)ccc1F	10.1039/C5MD00166H
		127039753	136742	0	None	22	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	454	8	1	4	4.3	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1	10.1039/C5MD00166H
		CHEMBL3740913	136742	0	None	22	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	454	8	1	4	4.3	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1	10.1039/C5MD00166H
		42625440	170813	0	None	30	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	320	5	0	2	3.4	O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1	10.1016/j.ejmech.2014.08.023
		CHEMBL445334	170813	0	None	30	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	320	5	0	2	3.4	O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1	10.1016/j.ejmech.2014.08.023
		25256855	189758	0	None	64	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	398	7	1	4	4.0	O=c1[nH]c2ccccc2n1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2014.08.023
		CHEMBL515939	189758	0	None	64	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	398	7	1	4	4.0	O=c1[nH]c2ccccc2n1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2014.08.023
		21048816	75500	0	None	30	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	385	7	0	3	4.9	CC(C)(CCCN1CCCC(c2ccccc2)C1)S(=O)(=O)c1ccccc1	10.1016/j.bmcl.2005.11.067
		CHEMBL204269	75500	0	None	30	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	385	7	0	3	4.9	CC(C)(CCCN1CCCC(c2ccccc2)C1)S(=O)(=O)c1ccccc1	10.1016/j.bmcl.2005.11.067
		11589069	96247	0	None	10	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	383	6	1	3	4.4	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm200547z
		CHEMBL260994	96247	0	None	10	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	383	6	1	3	4.4	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm200547z
		42625440	170813	0	None	30	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	320	5	0	2	3.4	O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1	10.1021/jm500880c
		CHEMBL445334	170813	0	None	30	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	320	5	0	2	3.4	O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1	10.1021/jm500880c
		42625440	170813	0	None	30	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	320	5	0	2	3.4	O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1	10.1021/jm8014553
		CHEMBL445334	170813	0	None	30	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	320	5	0	2	3.4	O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1	10.1021/jm8014553
		25256855	189758	0	None	64	3	Human	8.2	pKi	=	8.2	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	398	7	1	4	4.0	O=c1[nH]c2ccccc2n1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2009.02.008
		CHEMBL515939	189758	0	None	64	3	Human	8.2	pKi	=	8.2	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	398	7	1	4	4.0	O=c1[nH]c2ccccc2n1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2009.02.008
		11145126	204401	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	470	5	1	4	4.9	CN(C)C(=O)n1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
		CHEMBL71959	204401	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	470	5	1	4	4.9	CN(C)C(=O)n1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
		60196077	81819	0	None	20	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	298	4	1	4	2.8	COc1cccc(OC)c1-c1cccc(N2CCNCC2)c1	10.1021/jm3003679
		CHEMBL2164343	81819	0	None	20	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	298	4	1	4	2.8	COc1cccc(OC)c1-c1cccc(N2CCNCC2)c1	10.1021/jm3003679
		132525569	164049	0	None	1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranesDisplacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes	ChEMBL	272	3	0	5	2.1	CCc1cc(-c2ccoc2)nc(N2CCN(C)CC2)n1	10.1021/acs.jmedchem.7b01898
		CHEMBL4208934	164049	0	None	1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranesDisplacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes	ChEMBL	272	3	0	5	2.1	CCc1cc(-c2ccoc2)nc(N2CCN(C)CC2)n1	10.1021/acs.jmedchem.7b01898
		24768516	92586	0	None	11	3	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	433	9	1	3	5.1	CCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
		CHEMBL243523	92586	0	None	11	3	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	433	9	1	3	5.1	CCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
		44374207	52498	0	None	5	3	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	280	5	1	4	2.9	CN(C)CCSc1cccc(C2(O)CCCCC2)n1	10.1016/j.bmcl.2003.11.050
		CHEMBL159143	52498	0	None	5	3	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	280	5	1	4	2.9	CN(C)CCSc1cccc(C2(O)CCCCC2)n1	10.1016/j.bmcl.2003.11.050
		9911844	119870	1	None	43	2	Human	8.1	pKi	=	8.1	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	454	6	1	2	6.5	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(Cl)cc2)CC1)CCC3	10.1016/j.ejmech.2019.111705
		CHEMBL348890	119870	1	None	43	2	Human	8.1	pKi	=	8.1	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	454	6	1	2	6.5	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(Cl)cc2)CC1)CCC3	10.1016/j.ejmech.2019.111705
		9911844	119870	1	None	43	2	Human	8.1	pKi	=	8.1	Binding	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	454	6	1	2	6.5	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(Cl)cc2)CC1)CCC3	10.1016/s0960-894x(02)00842-9
		CHEMBL348890	119870	1	None	43	2	Human	8.1	pKi	=	8.1	Binding	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	454	6	1	2	6.5	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(Cl)cc2)CC1)CCC3	10.1016/s0960-894x(02)00842-9
		9911844	119870	1	None	43	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-HT7 receptor by the displacement of [3H]-5-CT] in human recombinant receptors in mammalian cellBinding affinity towards 5-HT7 receptor by the displacement of [3H]-5-CT] in human recombinant receptors in mammalian cell	ChEMBL	454	6	1	2	6.5	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(Cl)cc2)CC1)CCC3	10.1016/s0960-894x(02)00842-9
		CHEMBL348890	119870	1	None	43	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-HT7 receptor by the displacement of [3H]-5-CT] in human recombinant receptors in mammalian cellBinding affinity towards 5-HT7 receptor by the displacement of [3H]-5-CT] in human recombinant receptors in mammalian cell	ChEMBL	454	6	1	2	6.5	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(Cl)cc2)CC1)CCC3	10.1016/s0960-894x(02)00842-9
		162654006	180490	0	None	-29	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	425	7	1	6	3.6	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2o1	10.1016/j.ejmech.2020.112149
		CHEMBL4753094	180490	0	None	-29	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	425	7	1	6	3.6	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2o1	10.1016/j.ejmech.2020.112149
		162643812	181663	0	None	-6	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	435	7	1	5	4.0	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc2ccccc12	10.1016/j.ejmech.2020.112149
		CHEMBL4776225	181663	0	None	-6	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	435	7	1	5	4.0	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc2ccccc12	10.1016/j.ejmech.2020.112149
		9911844	119870	1	None	43	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	454	6	1	2	6.5	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(Cl)cc2)CC1)CCC3	10.1021/jm070279v
		CHEMBL348890	119870	1	None	43	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	454	6	1	2	6.5	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(Cl)cc2)CC1)CCC3	10.1021/jm070279v
		10873805	204694	2	None	-2	5	Human	8.1	pKi	=	8.1	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	437	5	0	2	4.6	O=C(c1ccc(F)cc1)C1CCN(CCc2ccc(I)cc2)CC1	10.1021/jm0200411
		CHEMBL73979	204694	2	None	-2	5	Human	8.1	pKi	=	8.1	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	437	5	0	2	4.6	O=C(c1ccc(F)cc1)C1CCN(CCc2ccc(I)cc2)CC1	10.1021/jm0200411
		5	139	72	None	-5	54	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.05.010
		5202	139	72	None	-5	54	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.05.010
		CHEMBL39	139	72	None	-5	54	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.05.010
		DB08839	139	72	None	-5	54	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.05.010
		35985234	88346	15	None	194	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	211	3	1	1	3.2	Cc1ccccc1-c1cccc(CCN)c1	10.1016/j.bmcl.2007.03.054
		CHEMBL234885	88346	15	None	194	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	211	3	1	1	3.2	Cc1ccccc1-c1cccc(CCN)c1	10.1016/j.bmcl.2007.03.054
		145976433	163930	0	None	2	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]lysergide from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]lysergide from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assay	ChEMBL	372	6	0	3	4.7	COc1cccc(CCN2CCN(c3ccccc3-c3ccccc3)CC2)c1	10.1021/acs.jmedchem.7b01898
		CHEMBL4207454	163930	0	None	2	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]lysergide from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]lysergide from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assay	ChEMBL	372	6	0	3	4.7	COc1cccc(CCN2CCN(c3ccccc3-c3ccccc3)CC2)c1	10.1021/acs.jmedchem.7b01898
		155522867	170826	0	None	2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	401	8	1	6	3.5	COC(=O)c1sccc1NC(=O)CCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2019.111690
		CHEMBL4453552	170826	0	None	2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	401	8	1	6	3.5	COC(=O)c1sccc1NC(=O)CCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2019.111690
		118713686	114391	0	None	-28	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	409	9	0	5	4.8	O=c1sc2ccccc2n1CCCCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
		CHEMBL3331389	114391	0	None	-28	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	409	9	0	5	4.8	O=c1sc2ccccc2n1CCCCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
		168271960	190108	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	368	6	0	3	3.5	CC1CCN(CCC[C@H]2CCCN2S(=O)(=O)c2ccccc2F)CC1	10.1021/acs.jmedchem.2c00633
		CHEMBL5173014	190108	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	368	6	0	3	3.5	CC1CCN(CCC[C@H]2CCCN2S(=O)(=O)c2ccccc2F)CC1	10.1021/acs.jmedchem.2c00633
		11395034	71499	0	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	385	9	1	4	3.0	O=C1C2CCCN2C(=O)N1CCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
		CHEMBL1926751	71499	0	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	385	9	1	4	3.0	O=C1C2CCCN2C(=O)N1CCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
		CHEMBL1962585	71499	0	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	385	9	1	4	3.0	O=C1C2CCCN2C(=O)N1CCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
		16747715	151043	0	None	58	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	239	4	0	1	3.8	Cc1ccccc1-c1cccc(CCN(C)C)c1	10.1016/j.bmc.2010.01.035
		CHEMBL395870	151043	0	None	58	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	239	4	0	1	3.8	Cc1ccccc1-c1cccc(CCN(C)C)c1	10.1016/j.bmc.2010.01.035
		16747715	151043	0	None	58	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	239	4	0	1	3.8	Cc1ccccc1-c1cccc(CCN(C)C)c1	10.1016/j.bmcl.2007.03.054
		CHEMBL395870	151043	0	None	58	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	239	4	0	1	3.8	Cc1ccccc1-c1cccc(CCN(C)C)c1	10.1016/j.bmcl.2007.03.054
		11515799	156939	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	348	6	1	2	4.5	CCC1(CCCCN2CCc3ccccc3C2)C(=O)Nc2ccccc21	10.1021/jm070279v
		CHEMBL407263	156939	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	348	6	1	2	4.5	CCC1(CCCCN2CCc3ccccc3C2)C(=O)Nc2ccccc21	10.1021/jm070279v
		136152971	95357	0	None	-4	6	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	293	2	2	3	3.5	C[C@@H]1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.078
		CHEMBL256694	95357	0	None	-4	6	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	293	2	2	3	3.5	C[C@@H]1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.078
		118713687	114393	0	None	-40	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	423	10	0	6	4.4	COc1ccccc1N1CCN(CCCCCCCn2c(=O)oc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
		CHEMBL3331390	114393	0	None	-40	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	423	10	0	6	4.4	COc1ccccc1N1CCN(CCCCCCCn2c(=O)oc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
		164621627	185483	0	None	-10	6	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	369	5	0	4	3.7	O=C1c2ccc(Cl)cc2CC1CCCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
		CHEMBL4862180	185483	0	None	-10	6	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	369	5	0	4	3.7	O=C1c2ccc(Cl)cc2CC1CCCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
		118713588	114373	0	None	3	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	397	7	0	6	3.7	COc1ccccc1N1CCN(CCCCn2c(=O)sc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
		CHEMBL3331257	114373	0	None	3	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	397	7	0	6	3.7	COc1ccccc1N1CCN(CCCCn2c(=O)sc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
		10429067	123630	0	None	43	5	Rat	8.1	pKi	=	8.1	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	367	8	0	3	5.4	CCCN(CCC)[C@H]1CCc2c(cccc2-c2c(OC)cccc2OC)C1	10.1021/jm0498102
		CHEMBL361875	123630	0	None	43	5	Rat	8.1	pKi	=	8.1	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	367	8	0	3	5.4	CCCN(CCC)[C@H]1CCc2c(cccc2-c2c(OC)cccc2OC)C1	10.1021/jm0498102
		10429067	123630	0	None	43	5	Rat	8.1	pKi	=	8.1	Binding	Inhibition of [3H]5-HT binding to rat 5-HT7 receptorInhibition of [3H]5-HT binding to rat 5-HT7 receptor	ChEMBL	367	8	0	3	5.4	CCCN(CCC)[C@H]1CCc2c(cccc2-c2c(OC)cccc2OC)C1	10.1021/jm0498102
		CHEMBL361875	123630	0	None	43	5	Rat	8.1	pKi	=	8.1	Binding	Inhibition of [3H]5-HT binding to rat 5-HT7 receptorInhibition of [3H]5-HT binding to rat 5-HT7 receptor	ChEMBL	367	8	0	3	5.4	CCCN(CCC)[C@H]1CCc2c(cccc2-c2c(OC)cccc2OC)C1	10.1021/jm0498102
		10257	738	31	None	-3	19	Rat	8.1	pKi	=	8.1	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	10.1021/jm030826m
		144	738	31	None	-3	19	Rat	8.1	pKi	=	8.1	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	10.1021/jm030826m
		CHEMBL416526	738	31	None	-3	19	Rat	8.1	pKi	=	8.1	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	10.1021/jm030826m
		DB01445	738	31	None	-3	19	Rat	8.1	pKi	=	8.1	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	10.1021/jm030826m
		10884517	102253	1	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	431	7	1	4	4.4	CC(=O)c1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
		CHEMBL303166	102253	1	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	431	7	1	4	4.4	CC(=O)c1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
		206	2493	16	None	-6	25	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/s0960-894x(00)00166-9
		68848	2493	16	None	-6	25	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/s0960-894x(00)00166-9
		CHEMBL12314	2493	16	None	-6	25	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/s0960-894x(00)00166-9
		11391654	180525	0	None	-1	4	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	273	2	1	3	3.0	CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
		CHEMBL4753511	180525	0	None	-1	4	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	273	2	1	3	3.0	CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
		5	139	72	None	-3	54	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2019.111705
		5202	139	72	None	-3	54	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2019.111705
		CHEMBL39	139	72	None	-3	54	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2019.111705
		DB08839	139	72	None	-3	54	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2019.111705
		9954003	71700	24	None	-15	9	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	422	5	2	4	3.8	C[C@H]1Oc2c(cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)NC1=O	10.1021/jm070516u
		CHEMBL196514	71700	24	None	-15	9	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	422	5	2	4	3.8	C[C@H]1Oc2c(cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)NC1=O	10.1021/jm070516u
		197033	199152	64	None	3	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	319	3	0	3	3.9	Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
		CHEMBL589390	199152	64	None	3	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	319	3	0	3	3.9	Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
		206	2493	16	None	-10	25	Human	8.1	pKi	=	8.1	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1021/jm030841r
		68848	2493	16	None	-10	25	Human	8.1	pKi	=	8.1	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1021/jm030841r
		CHEMBL12314	2493	16	None	-10	25	Human	8.1	pKi	=	8.1	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1021/jm030841r
		46205374	124588	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	321	3	1	2	4.5	COc1ccc(-c2ccccc2C(F)(F)F)cc1C1CCNC1	nan
		CHEMBL3640594	124588	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	321	3	1	2	4.5	COc1ccc(-c2ccccc2C(F)(F)F)cc1C1CCNC1	nan
		168268877	189970	0	None	-1	12	Human	8.1	pKi	=	8.1	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
		CHEMBL5170784	189970	0	None	-1	12	Human	8.1	pKi	=	8.1	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
		46205374	124588	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	321	3	1	2	4.5	COc1ccc(-c2ccccc2C(F)(F)F)cc1C1CCNC1	nan
		CHEMBL3640594	124588	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	321	3	1	2	4.5	COc1ccc(-c2ccccc2C(F)(F)F)cc1C1CCNC1	nan
		100	3805	58	None	-28	55	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm030030n
		2637	3805	58	None	-28	55	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm030030n
		5452	3805	58	None	-28	55	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm030030n
		CHEMBL479	3805	58	None	-28	55	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm030030n
		DB00679	3805	58	None	-28	55	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm030030n
		44460917	104410	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	297	4	0	3	3.3	C=C(C)c1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
		CHEMBL310317	104410	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	297	4	0	3	3.3	C=C(C)c1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
		44460980	205940	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	361	3	0	3	3.6	Brc1ccc2ccn(CCN3CCN4CCCCC4C3)c2c1	10.1016/s0960-894x(02)00438-9
		CHEMBL84270	205940	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	361	3	0	3	3.6	Brc1ccc2ccn(CCN3CCN4CCCCC4C3)c2c1	10.1016/s0960-894x(02)00438-9
		76321737	106419	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	397	5	0	4	5.0	COc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
		CHEMBL3121428	106419	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	397	5	0	4	5.0	COc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
		CHEMBL3139525	106419	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	397	5	0	4	5.0	COc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
		127026132	137846	0	None	6	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	432	8	1	6	2.9	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2cnn(C)c2)C3)c1	10.1016/j.ejmech.2015.11.040
		CHEMBL3760010	137846	0	None	6	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	432	8	1	6	2.9	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2cnn(C)c2)C3)c1	10.1016/j.ejmech.2015.11.040
		127041260	137056	0	None	5	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	430	7	0	4	4.1	CN(C1CCN(CCOc2ccccc2C(C)(C)C)CC1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2015.11.041
		CHEMBL3746806	137056	0	None	5	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	430	7	0	4	4.1	CN(C1CCN(CCOc2ccccc2C(C)(C)C)CC1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2015.11.041
		90654838	112687	0	None	1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	448	9	0	4	4.2	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
		CHEMBL3233668	112687	0	None	1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	448	9	0	4	4.2	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
		CHEMBL3304237	112687	0	None	1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	448	9	0	4	4.2	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
		155545625	173461	0	None	102	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	255	4	1	3	3.5	CCOc1ccc2[nH]cc(-c3cncn3CC)c2c1	10.1016/j.ejmech.2019.03.017
		CHEMBL4529615	173461	0	None	102	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	255	4	1	3	3.5	CCOc1ccc2[nH]cc(-c3cncn3CC)c2c1	10.1016/j.ejmech.2019.03.017
		56944864	157560	0	None	-27	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	457	8	2	3	5.0	Cc1cccc(S(=O)(=O)NCCCCN2CC=C(c3c[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
		CHEMBL4080369	157560	0	None	-27	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	457	8	2	3	5.0	Cc1cccc(S(=O)(=O)NCCCCN2CC=C(c3c[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
		135367816	164835	0	None	3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		CHEMBL4218801	164835	0	None	3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		145947937	167723	0	None	-13	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2c(C)cc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
		CHEMBL4207653	167723	0	None	-13	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2c(C)cc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
		CHEMBL4302655	167723	0	None	-13	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2c(C)cc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
		11478226	136940	0	None	12	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	465	10	1	5	4.6	COc1ccc(OC)c(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)c1	10.1021/jm049702f
		CHEMBL374297	136940	0	None	12	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	465	10	1	5	4.6	COc1ccc(OC)c(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)c1	10.1021/jm049702f
		57399494	70457	0	None	-1	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	386	4	0	3	4.4	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2020.115943
		CHEMBL1946124	70457	0	None	-1	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	386	4	0	3	4.4	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2020.115943
		135367816	164835	0	None	3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		CHEMBL4218801	164835	0	None	3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		11430856	78021	32	None	-134	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay	ChEMBL	450	10	2	5	3.0	CC(=O)Nc1cccc(N2CCN(CCCCNS(=O)(=O)CC3CCCCC3)CC2)c1	10.1021/jm0508641
		CHEMBL209821	78021	32	None	-134	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay	ChEMBL	450	10	2	5	3.0	CC(=O)Nc1cccc(N2CCN(CCCCNS(=O)(=O)CC3CCCCC3)CC2)c1	10.1021/jm0508641
		127035062	136451	0	None	-23	19	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7A receptor stably expressed in HEKT cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT7A receptor stably expressed in HEKT cell membrane after 90 mins by scintillation counting method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
		CHEMBL3735756	136451	0	None	-23	19	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7A receptor stably expressed in HEKT cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT7A receptor stably expressed in HEKT cell membrane after 90 mins by scintillation counting method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
		11261344	169308	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	476	9	1	6	4.7	COc1ccc2oc(N3CCN(CCCCCC(=O)NC4CCCc5ccccc54)CC3)nc2c1	10.1021/jm049702f
		CHEMBL441560	169308	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	476	9	1	6	4.7	COc1ccc2oc(N3CCN(CCCCCC(=O)NC4CCCc5ccccc54)CC3)nc2c1	10.1021/jm049702f
		135367858	163781	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
		CHEMBL4205846	163781	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
		216239	23795	118	None	-9	7	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counter	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1021/jm300338m
		CHEMBL1200485	23795	118	None	-9	7	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counter	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1021/jm300338m
		CHEMBL1336	23795	118	None	-9	7	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counter	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1021/jm300338m
		155560943	176567	0	None	-2344	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	382	4	2	6	3.2	COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2019.06.001
		CHEMBL4574931	176567	0	None	-2344	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	382	4	2	6	3.2	COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2019.06.001
		CHEMBL4597364	176567	0	None	-2344	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	382	4	2	6	3.2	COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2019.06.001
		10698929	99354	0	None	3	2	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	607	5	0	7	5.6	CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2c(OS(=O)(=O)C(F)(F)F)cccc2OS(=O)(=O)C(F)(F)F)c1-3	10.1021/jm0108505
		CHEMBL282413	99354	0	None	3	2	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	607	5	0	7	5.6	CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2c(OS(=O)(=O)C(F)(F)F)cccc2OS(=O)(=O)C(F)(F)F)c1-3	10.1021/jm0108505
		71449628	81369	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	404	7	1	3	4.4	O=C(NC1CCN(CCOc2cccc(-c3ccccc3)c2)C1)c1cccc(F)c1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159317	81369	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	404	7	1	3	4.4	O=C(NC1CCN(CCOc2cccc(-c3ccccc3)c2)C1)c1cccc(F)c1	10.1016/j.ejmech.2012.07.043
		122181251	121855	0	None	-27	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	448	7	1	5	3.0	COc1ccccc1N1CCN(CCCCN2C(=O)NC3(CCc4ccccc43)C2=O)CC1	10.1016/j.bmc.2015.04.026
		CHEMBL3589977	121855	0	None	-27	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	448	7	1	5	3.0	COc1ccccc1N1CCN(CCCCN2C(=O)NC3(CCc4ccccc43)C2=O)CC1	10.1016/j.bmc.2015.04.026
		156022244	177221	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	241	2	0	2	3.4	CN(C)[C@H]1CCc2c(cccc2-c2ccco2)C1	10.1016/j.bmc.2019.115262
		CHEMBL4635538	177221	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	241	2	0	2	3.4	CN(C)[C@H]1CCc2c(cccc2-c2ccco2)C1	10.1016/j.bmc.2019.115262
		76280896	105012	0	None	2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	462	10	1	6	3.7	O=C(CCCCCN1CCN(c2ncccc2-c2ccncc2)CC1)NCc1ccc(F)nc1	10.1016/j.bmc.2014.01.016
		CHEMBL3113601	105012	0	None	2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	462	10	1	6	3.7	O=C(CCCCCN1CCN(c2ncccc2-c2ccncc2)CC1)NCc1ccc(F)nc1	10.1016/j.bmc.2014.01.016
		25107583	192877	0	None	-2	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	489	12	1	7	3.0	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	10.1021/jm800615e
		CHEMBL522194	192877	0	None	-2	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	489	12	1	7	3.0	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	10.1021/jm800615e
		155533648	171885	0	None	-5	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	486	9	0	6	4.7	O=C1c2cccc3cccc(c23)C(=O)N1CCCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1	10.1016/j.bmcl.2019.06.029
		CHEMBL4469539	171885	0	None	-5	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	486	9	0	6	4.7	O=C1c2cccc3cccc(c23)C(=O)N1CCCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1	10.1016/j.bmcl.2019.06.029
		155564824	175530	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Inhibition of human 5HT7 by radio-ligand binding displacement assayInhibition of human 5HT7 by radio-ligand binding displacement assay	ChEMBL	412	4	3	6	3.9	C[C@H]1[C@@H]2C[C@]2(n2cc(-c3ccccc3)c3c(Nc4ccccc4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.6b00689
		CHEMBL4578381	175530	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Inhibition of human 5HT7 by radio-ligand binding displacement assayInhibition of human 5HT7 by radio-ligand binding displacement assay	ChEMBL	412	4	3	6	3.9	C[C@H]1[C@@H]2C[C@]2(n2cc(-c3ccccc3)c3c(Nc4ccccc4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.6b00689
		145954503	162419	0	None	-7	2	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	370	5	1	4	4.1	O[C@H](CCN1CCc2onc(-c3ccc(F)c(F)c3)c2C1)c1ccccc1	10.1016/j.ejmech.2018.04.010
		CHEMBL4166092	162419	0	None	-7	2	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	370	5	1	4	4.1	O[C@H](CCN1CCc2onc(-c3ccc(F)c(F)c3)c2C1)c1ccccc1	10.1016/j.ejmech.2018.04.010
		168288598	191773	0	None	-177	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	400	10	3	9	1.8	COc1ccccc1N1CCN(CCCCCCNc2nc(N)nc(N)n2)CC1	10.1016/j.ejmech.2021.113931
		CHEMBL5197911	191773	0	None	-177	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	400	10	3	9	1.8	COc1ccccc1N1CCN(CCCCCCNc2nc(N)nc(N)n2)CC1	10.1016/j.ejmech.2021.113931
		44278114	100205	0	None	-104	4	Human	6.2	pKi	=	6.2	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	334	5	1	3	3.8	CCCc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1	10.1016/s0960-894x(01)00241-4
		CHEMBL28833	100205	0	None	-104	4	Human	6.2	pKi	=	6.2	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	334	5	1	3	3.8	CCCc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1	10.1016/s0960-894x(01)00241-4
		126720425	162114	0	None	-354	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	369	4	1	5	3.7	CC(C)c1nc2c(N3CCNCC3)ccnc2n1Cc1cccc(Cl)c1	10.1016/j.ejmech.2017.12.053
		CHEMBL4161308	162114	0	None	-354	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	369	4	1	5	3.7	CC(C)c1nc2c(N3CCNCC3)ccnc2n1Cc1cccc(Cl)c1	10.1016/j.ejmech.2017.12.053
		135367858	163781	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
		CHEMBL4205846	163781	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
		127027386	137663	0	None	5	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	403	8	1	5	3.0	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccnc2)CC1	10.1016/j.ejmech.2015.11.040
		CHEMBL3758466	137663	0	None	5	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	403	8	1	5	3.0	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccnc2)CC1	10.1016/j.ejmech.2015.11.040
		156013612	177228	0	None	-7	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	452	9	0	7	5.9	c1ccc2oc(SCCCCCCN3CCN(c4nsc5ccccc45)CC3)nc2c1	10.1016/j.bmc.2020.115459
		CHEMBL4635603	177228	0	None	-7	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	452	9	0	7	5.9	c1ccc2oc(SCCCCCCN3CCN(c4nsc5ccccc45)CC3)nc2c1	10.1016/j.bmc.2020.115459
		90654840	112634	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	478	10	0	5	4.2	COc1ccccc1N1CCN(CCCCCN2C(=O)N(Cc3ccccc3)C(=O)C2(C)C)CC1	10.1016/j.ejmech.2014.01.065
		CHEMBL3233669	112634	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	478	10	0	5	4.2	COc1ccccc1N1CCN(CCCCCN2C(=O)N(Cc3ccccc3)C(=O)C2(C)C)CC1	10.1016/j.ejmech.2014.01.065
		CHEMBL3302757	112634	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	478	10	0	5	4.2	COc1ccccc1N1CCN(CCCCCN2C(=O)N(Cc3ccccc3)C(=O)C2(C)C)CC1	10.1016/j.ejmech.2014.01.065
		57399494	70457	0	None	-1	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	386	4	0	3	4.4	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2020.115943
		CHEMBL1946124	70457	0	None	-1	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	386	4	0	3	4.4	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2020.115943
		54758202	66009	0	None	9	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	497	7	1	3	6.4	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2c1cc(Cl)c(F)c2Cl	10.1021/jm200547z
		CHEMBL1836858	66009	0	None	9	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	497	7	1	3	6.4	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2c1cc(Cl)c(F)c2Cl	10.1021/jm200547z
		10895284	103109	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	430	7	1	3	5.0	CC(=O)C1(c2ccccc2)CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
		CHEMBL307686	103109	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	430	7	1	3	5.0	CC(=O)C1(c2ccccc2)CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
		117209964	186134	1	None	3	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4871980	186134	1	None	3	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		52952308	62580	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	389	6	1	5	4.6	N#Cc1ccc(N2CCC(NCCC(=O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
		CHEMBL1782793	62580	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	389	6	1	5	4.6	N#Cc1ccc(N2CCC(NCCC(=O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
		90654680	110101	0	None	-1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	468	8	1	4	3.5	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235752	110101	0	None	-1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	468	8	1	4	3.5	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2014.03.005
		46206022	124602	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	267	3	0	2	3.8	COc1ccccc1-c1ccccc1C1CCN(C)C1	nan
		CHEMBL3640608	124602	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	267	3	0	2	3.8	COc1ccccc1-c1ccccc1C1CCN(C)C1	nan
		46206022	124602	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	267	3	0	2	3.8	COc1ccccc1-c1ccccc1C1CCN(C)C1	nan
		CHEMBL3640608	124602	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	267	3	0	2	3.8	COc1ccccc1-c1ccccc1C1CCN(C)C1	nan
		155538451	172387	0	None	-2	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	485	10	0	5	5.2	CCOc1ccccc1N1CCN(CCCCCCN2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.bmcl.2019.06.029
		CHEMBL4476432	172387	0	None	-2	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	485	10	0	5	5.2	CCOc1ccccc1N1CCN(CCCCCCN2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.bmcl.2019.06.029
		117209964	186134	1	None	3	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4871980	186134	1	None	3	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		156019279	177973	0	None	1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	338	3	0	4	3.5	COc1cc2c3c(c1OC)-c1cc(N(C)C)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
		CHEMBL4645997	177973	0	None	1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	338	3	0	4	3.5	COc1cc2c3c(c1OC)-c1cc(N(C)C)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
		134157289	154081	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	422	6	0	4	5.3	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1Cl	10.1016/j.ejmech.2016.07.029
		CHEMBL3984812	154081	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	422	6	0	4	5.3	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1Cl	10.1016/j.ejmech.2016.07.029
		44455943	169002	5	None	-2	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	243	1	2	3	3.0	CCC1NC(N)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.080
		CHEMBL439240	169002	5	None	-2	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	243	1	2	3	3.0	CCC1NC(N)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.080
		118724637	120614	0	None	-4	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	464	6	0	8	2.3	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		CHEMBL3360997	120614	0	None	-4	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	464	6	0	8	2.3	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		CHEMBL3546115	120614	0	None	-4	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	464	6	0	8	2.3	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
		44582705	186996	0	None	-4	13	Human	6.1	pKi	=	6.1	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	399	9	0	4	4.5	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL490632	186996	0	None	-4	13	Human	6.1	pKi	=	6.1	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	399	9	0	4	4.5	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
		155563374	175246	0	None	-831	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting	ChEMBL	423	3	1	5	4.5	O=S(=O)(c1ccc2cccnc2c1)n1cc(C2=CCNCC2)c2cc(Cl)ccc21	10.1021/acsmedchemlett.6b00056
		CHEMBL4572158	175246	0	None	-831	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting	ChEMBL	423	3	1	5	4.5	O=S(=O)(c1ccc2cccnc2c1)n1cc(C2=CCNCC2)c2cc(Cl)ccc21	10.1021/acsmedchemlett.6b00056
		53376041	66371	0	None	-11	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	431	6	0	6	3.7	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2F)CC1	10.1016/j.ejmech.2011.04.060
		CHEMBL1851658	66371	0	None	-11	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	431	6	0	6	3.7	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2F)CC1	10.1016/j.ejmech.2011.04.060
		CHEMBL3215835	66371	0	None	-11	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	431	6	0	6	3.7	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2F)CC1	10.1016/j.ejmech.2011.04.060
		134133064	144735	0	None	4	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	314	5	0	3	3.0	CC1(C)CC(=O)N(CCCCN2Cc3ccccc3C2)C(=O)C1	10.1016/j.bmc.2016.09.019
		CHEMBL3908870	144735	0	None	4	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	314	5	0	3	3.0	CC1(C)CC(=O)N(CCCCN2Cc3ccccc3C2)C(=O)C1	10.1016/j.bmc.2016.09.019
		122483223	138109	0	None	5	7	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3764650	138109	0	None	5	7	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3765874	138109	0	None	5	7	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		56850387	71478	0	None	-1	3	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	365	8	1	3	3.2	O=C1C2CCCN2C(=O)N1CCCCNCCc1ccc2ccccc2c1	10.1021/jm2007886
		CHEMBL1926731	71478	0	None	-1	3	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	365	8	1	3	3.2	O=C1C2CCCN2C(=O)N1CCCCNCCc1ccc2ccccc2c1	10.1021/jm2007886
		CHEMBL1962455	71478	0	None	-1	3	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	365	8	1	3	3.2	O=C1C2CCCN2C(=O)N1CCCCNCCc1ccc2ccccc2c1	10.1021/jm2007886
		127026071	137760	0	None	25	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	450	7	1	4	4.5	CC(C)(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2015.11.040
		CHEMBL3759298	137760	0	None	25	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	450	7	1	4	4.5	CC(C)(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2015.11.040
		145963860	164226	0	None	15	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	434	8	1	4	4.2	CC(C)c1ccccc1OCC(C)N1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2017.03.057
		CHEMBL4211091	164226	0	None	15	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	434	8	1	4	4.2	CC(C)c1ccccc1OCC(C)N1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2017.03.057
		155525703	171053	0	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	452	8	1	8	1.6	COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4ncccn4)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
		CHEMBL4456962	171053	0	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	452	8	1	8	1.6	COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4ncccn4)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
		10950559	203965	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	457	6	1	3	5.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2C(F)(F)F)CC1)CCC3	10.1016/j.bmc.2019.06.028
		CHEMBL69388	203965	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	457	6	1	3	5.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2C(F)(F)F)CC1)CCC3	10.1016/j.bmc.2019.06.028
		122483223	138109	0	None	5	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3764650	138109	0	None	5	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3765874	138109	0	None	5	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		42626293	151125	0	None	1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	349	6	0	3	3.2	O=C1Cc2ccccc2N1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm8014553
		CHEMBL395933	151125	0	None	1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	349	6	0	3	3.2	O=C1Cc2ccccc2N1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm8014553
		11200511	201730	0	None	-74	8	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cellsInhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	403	5	2	3	4.3	CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3ccccc3Cl)cc12	10.1021/jm049243i
		CHEMBL606547	201730	0	None	-74	8	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cellsInhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	403	5	2	3	4.3	CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3ccccc3Cl)cc12	10.1021/jm049243i
		127036932	137348	0	None	-2	22	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay	ChEMBL	274	7	1	1	4.0	C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12	10.1016/j.bmcl.2015.12.053
		CHEMBL3752900	137348	0	None	-2	22	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay	ChEMBL	274	7	1	1	4.0	C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12	10.1016/j.bmcl.2015.12.053
		10950559	203965	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	457	6	1	3	5.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2C(F)(F)F)CC1)CCC3	10.1021/jm0104264
		CHEMBL69388	203965	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	457	6	1	3	5.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2C(F)(F)F)CC1)CCC3	10.1021/jm0104264
		122483223	138109	0	None	5	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3764650	138109	0	None	5	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3765874	138109	0	None	5	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		162662367	182044	0	None	18	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	531	10	0	5	7.7	COc1ccc(-c2ccccc2C2CCN(CCCCOc3ccc(-c4cn5ccccc5n4)cc3)CC2)cc1	10.1016/j.ejmech.2020.112395
		CHEMBL4781056	182044	0	None	18	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	531	10	0	5	7.7	COc1ccc(-c2ccccc2C2CCN(CCCCOc3ccc(-c4cn5ccccc5n4)cc3)CC2)cc1	10.1016/j.ejmech.2020.112395
		156015306	177614	0	None	1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	269	2	0	1	3.9	CN(C)[C@@H]1CCc2c(cccc2-c2ccccc2F)C1	10.1016/j.bmc.2019.115262
		CHEMBL4640899	177614	0	None	1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	269	2	0	1	3.9	CN(C)[C@@H]1CCc2c(cccc2-c2ccccc2F)C1	10.1016/j.bmc.2019.115262
		156020091	178188	0	None	-8	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	325	6	0	1	5.5	CCCN(CCC)[C@@H]1CCc2c(cccc2-c2ccccc2F)C1	10.1016/j.bmc.2019.115262
		CHEMBL4649327	178188	0	None	-8	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	325	6	0	1	5.5	CCCN(CCC)[C@@H]1CCc2c(cccc2-c2ccccc2F)C1	10.1016/j.bmc.2019.115262
		145977338	163717	0	None	-74	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	259	3	2	4	2.2	Oc1ccccc1C1=NC(Cc2c[nH]cn2)CS1	10.1021/acs.jnatprod.7b00317
		CHEMBL4205064	163717	0	None	-74	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	259	3	2	4	2.2	Oc1ccccc1C1=NC(Cc2c[nH]cn2)CS1	10.1021/acs.jnatprod.7b00317
		156021059	178137	0	None	-147	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	436	8	0	8	3.5	O=c1n(CCCCCCN2CCN(c3nsc4ccccc34)CC2)nc2ccccn12	10.1016/j.bmc.2020.115459
		CHEMBL4648581	178137	0	None	-147	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	436	8	0	8	3.5	O=c1n(CCCCCCN2CCN(c3nsc4ccccc34)CC2)nc2ccccn12	10.1016/j.bmc.2020.115459
		11257767	67031	9	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	389	7	1	5	2.1	COc1ccccc1N1CCN(CCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1021/jm049743b
		CHEMBL187088	67031	9	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	389	7	1	5	2.1	COc1ccccc1N1CCN(CCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1021/jm049743b
		11325873	125795	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	360	7	1	4	2.4	COc1ccc2c(c1)CCN(CCCNS(=O)(=O)c1ccccc1)C2	10.1021/jm049743b
		CHEMBL364795	125795	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	360	7	1	4	2.4	COc1ccc2c(c1)CCN(CCCNS(=O)(=O)c1ccccc1)C2	10.1021/jm049743b
		118626042	165570	0	None	-9	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	489	6	1	5	4.1	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3[nH]ccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4242170	165570	0	None	-9	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	489	6	1	5	4.1	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3[nH]ccc23)CC1	10.1016/j.ejmech.2018.01.002
		162666794	183732	0	None	-4	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	8	1	4	4.9	COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4784726	183732	0	None	-4	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	8	1	4	4.9	COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4803549	183732	0	None	-4	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	8	1	4	4.9	COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
		155556806	174530	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	381	7	1	4	4.3	O=c1[nH]c(CCCCN2CCC(Cc3ccccc3)CC2)nc2ccsc12	10.1016/j.ejmech.2019.111690
		CHEMBL4555702	174530	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	381	7	1	4	4.3	O=c1[nH]c(CCCCN2CCC(Cc3ccccc3)CC2)nc2ccsc12	10.1016/j.ejmech.2019.111690
		164628817	186277	0	None	-14	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	349	6	0	4	3.4	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc2c(c1)CCC2	10.1016/j.ejmech.2021.113243
		CHEMBL4874069	186277	0	None	-14	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	349	6	0	4	3.4	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc2c(c1)CCC2	10.1016/j.ejmech.2021.113243
		44391622	65992	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	333	3	0	3	4.4	COc1c(-c2ccc3c(c2)C[C@H](N(C)C)CO3)ccc2ccccc12	10.1016/j.bmcl.2004.11.013
		CHEMBL183676	65992	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	333	3	0	3	4.4	COc1c(-c2ccc3c(c2)C[C@H](N(C)C)CO3)ccc2ccccc12	10.1016/j.bmcl.2004.11.013
		46204424	124564	7	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	239	3	1	2	3.0	Cc1cccc(-c2cccc(OC3CNC3)c2)c1	nan
		CHEMBL3640571	124564	7	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	239	3	1	2	3.0	Cc1cccc(-c2cccc(OC3CNC3)c2)c1	nan
		46204424	124564	7	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	239	3	1	2	3.0	Cc1cccc(-c2cccc(OC3CNC3)c2)c1	nan
		CHEMBL3640571	124564	7	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	239	3	1	2	3.0	Cc1cccc(-c2cccc(OC3CNC3)c2)c1	nan
		156020902	178029	0	None	-2	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	378	5	0	4	4.3	COc1cc2c3c(c1OCC1CC1)-c1cc(N(C)C)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
		CHEMBL4646861	178029	0	None	-2	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	378	5	0	4	4.3	COc1cc2c3c(c1OCC1CC1)-c1cc(N(C)C)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
		53320866	57024	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	322	3	1	2	4.5	Clc1ccc(Cn2cc(-c3ccccc3)c3c2CCNC3)cc1	10.1016/j.bmcl.2010.11.078
		CHEMBL1644486	57024	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	322	3	1	2	4.5	Clc1ccc(Cn2cc(-c3ccccc3)c3c2CCNC3)cc1	10.1016/j.bmcl.2010.11.078
		10383646	18762	0	None	-398	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cells	ChEMBL	356	3	1	5	2.1	CN1CCN(c2ccc3[nH]nc(S(=O)(=O)c4ccccc4)c3c2)CC1	10.1021/jm1007825
		CHEMBL1277917	18762	0	None	-398	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cells	ChEMBL	356	3	1	5	2.1	CN1CCN(c2ccc3[nH]nc(S(=O)(=O)c4ccccc4)c3c2)CC1	10.1021/jm1007825
		46205043	124578	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	309	6	1	3	3.8	Cc1ccccc1-c1ccc(OCC2CC2)c(OC2CNC2)c1	nan
		CHEMBL3640584	124578	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	309	6	1	3	3.8	Cc1ccccc1-c1ccc(OCC2CC2)c(OC2CNC2)c1	nan
		46205043	124578	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	309	6	1	3	3.8	Cc1ccccc1-c1ccc(OCC2CC2)c(OC2CNC2)c1	nan
		CHEMBL3640584	124578	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	309	6	1	3	3.8	Cc1ccccc1-c1ccc(OCC2CC2)c(OC2CNC2)c1	nan
		127051843	140751	0	None	-33	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	0	3	3.6	N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818200	140751	0	None	-33	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	0	3	3.6	N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		127051843	140751	0	None	-33	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	0	3	3.6	N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818200	140751	0	None	-33	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	0	3	3.6	N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		46204084	124553	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2ccc(C)cc2)cc1OC1CNC1	nan
		CHEMBL3640560	124553	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2ccc(C)cc2)cc1OC1CNC1	nan
		46204084	124553	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2ccc(C)cc2)cc1OC1CNC1	nan
		CHEMBL3640560	124553	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2ccc(C)cc2)cc1OC1CNC1	nan
		134135516	144173	0	None	7	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	469	10	1	6	3.5	N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3ncccc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		CHEMBL3904094	144173	0	None	7	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	469	10	1	6	3.5	N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3ncccc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		25107582	187584	0	None	-9	3	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	501	12	1	6	4.1	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	10.1021/jm800615e
		CHEMBL494661	187584	0	None	-9	3	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	501	12	1	6	4.1	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	10.1021/jm800615e
		122196373	124287	0	None	-34	5	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	471	7	0	6	6.4	Fc1ccc2c(C3CCN(CCCOc4ccc(-c5nc6ccccc6o5)cc4)CC3)noc2c1	10.1016/j.bmcl.2015.09.045
		CHEMBL3634813	124287	0	None	-34	5	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	471	7	0	6	6.4	Fc1ccc2c(C3CCN(CCCOc4ccc(-c5nc6ccccc6o5)cc4)CC3)noc2c1	10.1016/j.bmcl.2015.09.045
		122181342	121884	0	None	-25	2	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	494	7	1	4	4.9	O=C1NC2(CCC(c3ccccc3)CC2)C(=O)N1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2015.04.026
		CHEMBL3590094	121884	0	None	-25	2	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	494	7	1	4	4.9	O=C1NC2(CCC(c3ccccc3)CC2)C(=O)N1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2015.04.026
		118731354	118190	0	None	-5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	496	10	0	4	4.9	CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(=O)N2CCCCC2)CC1	10.1016/j.ejmech.2014.12.041
		CHEMBL3409037	118190	0	None	-5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	496	10	0	4	4.9	CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(=O)N2CCCCC2)CC1	10.1016/j.ejmech.2014.12.041
		57392825	68397	0	None	-5	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	496	9	0	4	4.8	CN1C(=O)N(CCCCCN2CCN(c3ccccc3)CC2)C(c2ccccc2)(c2ccccc2)C1=O	10.1016/j.ejmech.2014.01.065
		CHEMBL1916744	68397	0	None	-5	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	496	9	0	4	4.8	CN1C(=O)N(CCCCCN2CCN(c3ccccc3)CC2)C(c2ccccc2)(c2ccccc2)C1=O	10.1016/j.ejmech.2014.01.065
		CHEMBL3233402	68397	0	None	-5	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	496	9	0	4	4.8	CN1C(=O)N(CCCCCN2CCN(c3ccccc3)CC2)C(c2ccccc2)(c2ccccc2)C1=O	10.1016/j.ejmech.2014.01.065
		71602739	89690	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1cccc(-c2ccccc2CN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2013.02.038
		CHEMBL2376462	89690	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1cccc(-c2ccccc2CN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2013.02.038
		164628817	186277	0	None	-14	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	349	6	0	4	3.4	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc2c(c1)CCC2	10.1016/j.ejmech.2021.113243
		CHEMBL4874069	186277	0	None	-14	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	349	6	0	4	3.4	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc2c(c1)CCC2	10.1016/j.ejmech.2021.113243
		56649649	67857	0	None	-91	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	480	8	0	5	4.6	COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)CC3)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
		CHEMBL1910140	67857	0	None	-91	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	480	8	0	5	4.6	COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)CC3)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
		59511191	185523	3	None	1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	228	2	2	3	1.5	c1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4862745	185523	3	None	1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	228	2	2	3	1.5	c1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		90656689	110986	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	353	7	1	5	3.1	COC(=O)c1cccc(NCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262419	110986	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	353	7	1	5	3.1	COC(=O)c1cccc(NCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
		46204085	124554	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2ccc(F)c(C)c2)cc1OC1CNC1	nan
		CHEMBL3640561	124554	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2ccc(F)c(C)c2)cc1OC1CNC1	nan
		46204085	124554	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2ccc(F)c(C)c2)cc1OC1CNC1	nan
		CHEMBL3640561	124554	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2ccc(F)c(C)c2)cc1OC1CNC1	nan
		134148917	148423	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	285	4	0	4	3.2	COc1ccccc1-c1cc(CN(C)C)cc2c1OCO2	10.1016/j.ejmech.2016.07.029
		CHEMBL3937741	148423	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	285	4	0	4	3.2	COc1ccccc1-c1cc(CN(C)C)cc2c1OCO2	10.1016/j.ejmech.2016.07.029
		35391328	68411	1	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	316	5	1	3	2.0	O=S(=O)(NCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2011.09.044
		CHEMBL1917332	68411	1	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	316	5	1	3	2.0	O=S(=O)(NCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2011.09.044
		155535879	176669	0	None	-194	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	352	3	2	5	3.2	Cc1nc(N)[nH]c1-c1ccc2ccn(S(=O)(=O)c3ccccc3)c2c1	10.1016/j.ejmech.2019.06.001
		CHEMBL4472629	176669	0	None	-194	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	352	3	2	5	3.2	Cc1nc(N)[nH]c1-c1ccc2ccn(S(=O)(=O)c3ccccc3)c2c1	10.1016/j.ejmech.2019.06.001
		CHEMBL4598209	176669	0	None	-194	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	352	3	2	5	3.2	Cc1nc(N)[nH]c1-c1ccc2ccn(S(=O)(=O)c3ccccc3)c2c1	10.1016/j.ejmech.2019.06.001
		127052488	140799	0	None	-23	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	477	8	0	4	6.3	Fc1ccc(C(c2ccc(F)cc2)N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.bmc.2016.06.011
		CHEMBL3818799	140799	0	None	-23	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	477	8	0	4	6.3	Fc1ccc(C(c2ccc(F)cc2)N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.bmc.2016.06.011
		90654672	110093	0	None	-1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	480	9	1	5	3.5	CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235744	110093	0	None	-1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	480	9	1	5	3.5	CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
		42428409	68410	6	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	366	5	1	3	3.2	O=S(=O)(NCCN1CCc2ccccc2C1)c1ccc2ccccc2c1	10.1016/j.bmc.2011.09.044
		CHEMBL1917331	68410	6	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	366	5	1	3	3.2	O=S(=O)(NCCN1CCc2ccccc2C1)c1ccc2ccccc2c1	10.1016/j.bmc.2011.09.044
		71451455	81418	0	None	-4	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	454	9	1	5	4.1	CSc1ccccc1OCCN1CCC(CNS(=O)(=O)c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159461	81418	0	None	-4	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	454	9	1	5	4.1	CSc1ccccc1OCCN1CCC(CNS(=O)(=O)c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2012.07.043
		90654672	110093	0	None	-1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	480	9	1	5	3.5	CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.12.041
		CHEMBL3235744	110093	0	None	-1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	480	9	1	5	3.5	CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.12.041
		90654856	112693	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	584	9	0	4	6.8	CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.ejmech.2014.01.065
		CHEMBL3233677	112693	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	584	9	0	4	6.8	CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.ejmech.2014.01.065
		CHEMBL3304304	112693	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	584	9	0	4	6.8	CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.ejmech.2014.01.065
		59511191	185523	3	None	1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	228	2	2	3	1.5	c1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4862745	185523	3	None	1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	228	2	2	3	1.5	c1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		164621627	185483	0	None	-10	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	369	5	0	4	3.7	O=C1c2ccc(Cl)cc2CC1CCCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
		CHEMBL4862180	185483	0	None	-10	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	369	5	0	4	3.7	O=C1c2ccc(Cl)cc2CC1CCCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
		42618266	191079	0	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	408	9	1	5	3.7	COc1ccccc1N1CCN(CCCCCCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
		CHEMBL518752	191079	0	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	408	9	1	5	3.7	COc1ccccc1N1CCN(CCCCCCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
		11266074	66266	1	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	283	3	1	3	3.2	COc1cccc(OC)c1-c1cccc2c1CC[C@H](N)C2	10.1021/jm0498102
		CHEMBL184666	66266	1	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	283	3	1	3	3.2	COc1cccc(OC)c1-c1cccc2c1CC[C@H](N)C2	10.1021/jm0498102
		75201901	166425	19	None	-575	24	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4277264	166425	19	None	-575	24	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		44439389	91780	0	None	8	2	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	324	3	1	5	2.8	COc1ccc2[nH]c3c(c2c1)CCN=C3c1cc([N+](=O)[O-])cn1C	10.1016/j.bmcl.2007.01.093
		CHEMBL241099	91780	0	None	8	2	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	324	3	1	5	2.8	COc1ccc2[nH]c3c(c2c1)CCN=C3c1cc([N+](=O)[O-])cn1C	10.1016/j.bmcl.2007.01.093
		146680920	171874	0	None	-2570	6	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting	ChEMBL	419	4	1	6	3.8	COc1ccc2c(c1)c(C1=CCNCC1)cn2S(=O)(=O)c1cncc2ccccc12	10.1021/acsmedchemlett.6b00056
		CHEMBL4469309	171874	0	None	-2570	6	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting	ChEMBL	419	4	1	6	3.8	COc1ccc2c(c1)c(C1=CCNCC1)cn2S(=O)(=O)c1cncc2ccccc12	10.1021/acsmedchemlett.6b00056
		168269719	190011	0	None	-2	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	444	7	3	8	2.9	COc1ccccc1N1CCN(c2nc(N)nc(NCCc3c[nH]c4ccccc34)n2)CC1	10.1016/j.ejmech.2021.113931
		CHEMBL5171456	190011	0	None	-2	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	444	7	3	8	2.9	COc1ccccc1N1CCN(c2nc(N)nc(NCCc3c[nH]c4ccccc34)n2)CC1	10.1016/j.ejmech.2021.113931
		127029652	138328	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	516	8	2	5	3.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
		CHEMBL3771222	138328	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	516	8	2	5	3.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
		57399089	68420	0	None	-21	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	454	9	1	6	3.1	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2cnc3ccccc3c2)CC1	10.1016/j.bmc.2011.09.044
		CHEMBL1917341	68420	0	None	-21	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	454	9	1	6	3.1	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2cnc3ccccc3c2)CC1	10.1016/j.bmc.2011.09.044
		127029652	138328	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from 5-HT7 receptor (unknown origin)Displacement of [3H]-5-carboxamidotryptamine from 5-HT7 receptor (unknown origin)	ChEMBL	516	8	2	5	3.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1016/j.bmcl.2018.02.003
		127029652	138328	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from 5-HT7 receptor (unknown origin)Displacement of [3H]-5-carboxamidotryptamine from 5-HT7 receptor (unknown origin)	ChEMBL	516	8	2	5	3.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1039/C8MD00168E
		CHEMBL3771222	138328	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from 5-HT7 receptor (unknown origin)Displacement of [3H]-5-carboxamidotryptamine from 5-HT7 receptor (unknown origin)	ChEMBL	516	8	2	5	3.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1016/j.bmcl.2018.02.003
		CHEMBL3771222	138328	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from 5-HT7 receptor (unknown origin)Displacement of [3H]-5-carboxamidotryptamine from 5-HT7 receptor (unknown origin)	ChEMBL	516	8	2	5	3.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1039/C8MD00168E
		134154531	152728	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	418	7	0	5	4.7	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OC	10.1016/j.ejmech.2016.07.029
		CHEMBL3973160	152728	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	418	7	0	5	4.7	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OC	10.1016/j.ejmech.2016.07.029
		9843889	16306	0	None	1	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	399	7	0	3	4.8	O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/s0960-894x(00)00166-9
		CHEMBL12259	16306	0	None	1	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	399	7	0	3	4.8	O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/s0960-894x(00)00166-9
		49850874	56462	0	None	-251	9	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	450	6	1	4	5.2	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5ccccc5)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1632210	56462	0	None	-251	9	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	450	6	1	4	5.2	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5ccccc5)c4)CC3)cccc2n1	10.1021/jm100714c
		11397149	56475	0	None	-251	7	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	465	6	2	4	5.6	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)Nc5ccccc5)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1632223	56475	0	None	-251	7	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	465	6	2	4	5.6	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)Nc5ccccc5)c4)CC3)cccc2n1	10.1021/jm100714c
		75306277	109254	0	None	-39	23	Human	7.1	pKi	=	7.1	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	308	0	0	3	4.2	CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3	10.1039/C2MD00311B
		CHEMBL3217984	109254	0	None	-39	23	Human	7.1	pKi	=	7.1	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	308	0	0	3	4.2	CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3	10.1039/C2MD00311B
		281	3510	28	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm030841r
		5312148	3510	28	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm030841r
		CHEMBL12264	3510	28	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm030841r
		9843889	16306	0	None	1	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	399	7	0	3	4.8	O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1021/jm030841r
		CHEMBL12259	16306	0	None	1	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	399	7	0	3	4.8	O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1021/jm030841r
		71602739	89690	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1cccc(-c2ccccc2CN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2013.02.038
		CHEMBL2376462	89690	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1cccc(-c2ccccc2CN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2013.02.038
		117209911	186329	1	None	5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
		CHEMBL4874854	186329	1	None	5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
		6540428	184864	1	None	-19	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	353	4	2	4	1.9	CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1016/j.ejmech.2019.111705
		CHEMBL3989558	184864	1	None	-19	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	353	4	2	4	1.9	CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1016/j.ejmech.2019.111705
		CHEMBL485253	184864	1	None	-19	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	353	4	2	4	1.9	CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1016/j.ejmech.2019.111705
		9804612	90535	0	None	-19	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	467	6	1	5	4.5	Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cc(F)cc2n1	10.1016/j.bmcl.2006.11.031
		CHEMBL238730	90535	0	None	-19	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	467	6	1	5	4.5	Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cc(F)cc2n1	10.1016/j.bmcl.2006.11.031
		44439167	90557	0	None	-7	10	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
		CHEMBL238732	90557	0	None	-7	10	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
		135398745	2914	112	None	-95	65	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm070516u
		47	2914	112	None	-95	65	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm070516u
		CHEMBL715	2914	112	None	-95	65	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm070516u
		DB00334	2914	112	None	-95	65	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm070516u
		76518515	140870	0	None	-4	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	454	7	1	5	5.8	O=C(CCCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
		CHEMBL3818881	140870	0	None	-4	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	454	7	1	5	5.8	O=C(CCCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
		CHEMBL3819714	140870	0	None	-4	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	454	7	1	5	5.8	O=C(CCCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
		60167166	75295	0	None	-25	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	371	5	0	4	4.7	Clc1ccc(N2CCN(CCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.ejmech.2012.03.042
		CHEMBL2037430	75295	0	None	-25	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	371	5	0	4	4.7	Clc1ccc(N2CCN(CCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.ejmech.2012.03.042
		44395796	66962	0	None	-5	2	Rat	6.1	pKi	=	6.1	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	343	6	0	5	1.5	COc1ccccc1N1CCN(C/C=C\CN2C(=O)CCC2=O)CC1	10.1016/j.bmcl.2004.09.029
		CHEMBL186734	66962	0	None	-5	2	Rat	6.1	pKi	=	6.1	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	343	6	0	5	1.5	COc1ccccc1N1CCN(C/C=C\CN2C(=O)CCC2=O)CC1	10.1016/j.bmcl.2004.09.029
		164613297	184617	0	None	-19	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	6	1	7	2.5	CN1CCN(c2nc(N)nc(CCCOc3cc(Cl)ccc3Cl)n2)CC1	10.1016/j.ejmech.2020.112529
		CHEMBL4849230	184617	0	None	-19	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	6	1	7	2.5	CN1CCN(c2nc(N)nc(CCCOc3cc(Cl)ccc3Cl)n2)CC1	10.1016/j.ejmech.2020.112529
		13702393	155025	2	None	-7	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	181	0	2	3	1.4	NC1=Nc2cccc(Cl)c2CN1	10.1016/j.bmcl.2007.10.080
		CHEMBL401541	155025	2	None	-7	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	181	0	2	3	1.4	NC1=Nc2cccc(Cl)c2CN1	10.1016/j.bmcl.2007.10.080
		CHEMBL556983	155025	2	None	-7	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	181	0	2	3	1.4	NC1=Nc2cccc(Cl)c2CN1	10.1016/j.bmcl.2007.10.080
		122483249	138094	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.3	CC1CCCN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
		CHEMBL3764970	138094	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.3	CC1CCCN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
		CHEMBL3765842	138094	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.3	CC1CCCN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
		127052488	140799	0	None	-23	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	477	8	0	4	6.3	Fc1ccc(C(c2ccc(F)cc2)N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.bmc.2016.06.011
		CHEMBL3818799	140799	0	None	-23	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	477	8	0	4	6.3	Fc1ccc(C(c2ccc(F)cc2)N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.bmc.2016.06.011
		168287126	191565	0	None	4	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	414	6	3	7	2.9	Nc1nc(NCCc2c[nH]c3ccccc23)nc(N2CCN(c3ccccc3)CC2)n1	10.1016/j.ejmech.2021.113931
		CHEMBL5194826	191565	0	None	4	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	414	6	3	7	2.9	Nc1nc(NCCc2c[nH]c3ccccc23)nc(N2CCN(c3ccccc3)CC2)n1	10.1016/j.ejmech.2021.113931
		162671691	183761	0	None	-6	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	481	10	1	6	5.0	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4792268	183761	0	None	-6	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	481	10	1	6	5.0	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4803838	183761	0	None	-6	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	481	10	1	6	5.0	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
		136118730	76244	0	None	-1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2cccc(Br)c12	10.1016/j.bmc.2013.09.011
		CHEMBL2058407	76244	0	None	-1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2cccc(Br)c12	10.1016/j.bmc.2013.09.011
		162647425	179577	1	None	-208	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta plate reader analysis	ChEMBL	584	13	0	7	5.3	C#CCN(C)Cc1ccc(OCCCCCN2CCN(c3cccc4c3ccn4S(=O)(=O)c3ccccc3)CC2)cc1	10.1016/j.ejmech.2020.112765
		CHEMBL4741978	179577	1	None	-208	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta plate reader analysis	ChEMBL	584	13	0	7	5.3	C#CCN(C)Cc1ccc(OCCCCCN2CCN(c3cccc4c3ccn4S(=O)(=O)c3ccccc3)CC2)cc1	10.1016/j.ejmech.2020.112765
		10154897	65263	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	350	8	3	7	3.1	CC(Nc1nc(N)nc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
		CHEMBL182797	65263	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	350	8	3	7	3.1	CC(Nc1nc(N)nc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
		44393075	65727	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	352	7	3	6	3.4	CC(Nc1nc(N)nc(NCCc2ccccc2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
		CHEMBL183462	65727	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	352	7	3	6	3.4	CC(Nc1nc(N)nc(NCCc2ccccc2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
		197033	199152	64	None	3	8	Human	8.1	pKi	=	8.1	Binding	Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant	ChEMBL	319	3	0	3	3.9	Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1	10.1016/j.bmcl.2021.128275
		CHEMBL589390	199152	64	None	3	8	Human	8.1	pKi	=	8.1	Binding	Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant	ChEMBL	319	3	0	3	3.9	Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1	10.1016/j.bmcl.2021.128275
		197033	199152	64	None	3	8	Human	8.1	pKi	=	8.1	Binding	Binding affinity to 5HT7 receptor by radioligand displacement assayBinding affinity to 5HT7 receptor by radioligand displacement assay	ChEMBL	319	3	0	3	3.9	Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1	10.1016/j.ejmech.2009.10.035
		CHEMBL589390	199152	64	None	3	8	Human	8.1	pKi	=	8.1	Binding	Binding affinity to 5HT7 receptor by radioligand displacement assayBinding affinity to 5HT7 receptor by radioligand displacement assay	ChEMBL	319	3	0	3	3.9	Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1	10.1016/j.ejmech.2009.10.035
		11199511	75433	0	None	4	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	369	6	0	3	4.2	O=S(=O)(c1ccccc1)C1(CCCN2CCc3ccccc3C2)CCC1	10.1016/j.bmcl.2009.06.038
		CHEMBL204171	75433	0	None	4	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	369	6	0	3	4.2	O=S(=O)(c1ccccc1)C1(CCCN2CCc3ccccc3C2)CCC1	10.1016/j.bmcl.2009.06.038
		56850385	71477	0	None	6	3	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	351	7	1	3	3.1	O=C1C2CCCN2C(=O)N1CCCCNCc1ccc2ccccc2c1	10.1021/jm2007886
		CHEMBL1926730	71477	0	None	6	3	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	351	7	1	3	3.1	O=C1C2CCCN2C(=O)N1CCCCNCc1ccc2ccccc2c1	10.1021/jm2007886
		CHEMBL1962454	71477	0	None	6	3	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	351	7	1	3	3.1	O=C1C2CCCN2C(=O)N1CCCCNCc1ccc2ccccc2c1	10.1021/jm2007886
		44408833	74452	0	None	112	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	363	6	0	3	4.5	CC(C)(CCCN1CC[C@@H]2CCCC[C@H]2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2011.09.044
		CHEMBL202780	74452	0	None	112	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	363	6	0	3	4.5	CC(C)(CCCN1CC[C@@H]2CCCC[C@H]2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2011.09.044
		168282454	191215	0	None	3	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	485	11	4	8	3.6	Nc1nc(NCCCCN2CCN(c3ccccc3)CC2)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
		CHEMBL5189648	191215	0	None	3	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	485	11	4	8	3.6	Nc1nc(NCCCCN2CCN(c3ccccc3)CC2)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
		168292411	191890	0	None	8	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	457	9	4	8	2.8	Nc1nc(NCCc2c[nH]c3ccccc23)nc(NCCN2CCN(c3ccccc3)CC2)n1	10.1016/j.ejmech.2021.113931
		CHEMBL5199820	191890	0	None	8	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	457	9	4	8	2.8	Nc1nc(NCCc2c[nH]c3ccccc23)nc(NCCN2CCN(c3ccccc3)CC2)n1	10.1016/j.ejmech.2021.113931
		145984065	165751	0	None	1	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	1	4	5.7	O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4246630	165751	0	None	1	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	1	4	5.7	O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1	10.1016/j.ejmech.2018.01.002
		134141166	146757	0	None	15	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	496	11	1	5	5.2	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(C#N)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		CHEMBL3924375	146757	0	None	15	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	496	11	1	5	5.2	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(C#N)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		145946956	167595	0	None	12	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	532	8	2	5	3.9	CC1(c2ccc(Cl)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1016/j.ejmech.2018.01.093
		CHEMBL4166804	167595	0	None	12	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	532	8	2	5	3.9	CC1(c2ccc(Cl)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1016/j.ejmech.2018.01.093
		CHEMBL4300883	167595	0	None	12	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	532	8	2	5	3.9	CC1(c2ccc(Cl)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1016/j.ejmech.2018.01.093
		155551353	173962	0	None	51	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	323	1	1	2	3.2	Cn1cncc1-c1c[nH]c2ccc(I)cc12	10.1016/j.ejmech.2019.03.017
		CHEMBL4541526	173962	0	None	51	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	323	1	1	2	3.2	Cn1cncc1-c1c[nH]c2ccc(I)cc12	10.1016/j.ejmech.2019.03.017
		127041108	136595	0	None	12	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	487	8	1	5	4.7	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc2ncccc12	10.1039/C5MD00166H
		CHEMBL3739582	136595	0	None	12	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	487	8	1	5	4.7	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc2ncccc12	10.1039/C5MD00166H
		127037679	136675	0	None	18	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	438	8	1	4	3.9	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cc(F)ccc2F)CC1	10.1039/C5MD00166H
		CHEMBL3740235	136675	0	None	18	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	438	8	1	4	3.9	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cc(F)ccc2F)CC1	10.1039/C5MD00166H
		127040760	136891	0	None	22	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	436	8	1	4	4.3	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(Cl)c2)CC1	10.1039/C5MD00166H
		CHEMBL3742251	136891	0	None	22	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	436	8	1	4	4.3	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(Cl)c2)CC1	10.1039/C5MD00166H
		11391654	180525	0	None	-1	4	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	273	2	1	3	3.0	CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
		CHEMBL4753511	180525	0	None	-1	4	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	273	2	1	3	3.0	CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
		44408833	74452	0	None	112	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	363	6	0	3	4.5	CC(C)(CCCN1CC[C@@H]2CCCC[C@H]2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmcl.2005.11.067
		CHEMBL202780	74452	0	None	112	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	363	6	0	3	4.5	CC(C)(CCCN1CC[C@@H]2CCCC[C@H]2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmcl.2005.11.067
		11199511	75433	0	None	4	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	369	6	0	3	4.2	O=S(=O)(c1ccccc1)C1(CCCN2CCc3ccccc3C2)CCC1	10.1016/j.bmcl.2005.11.067
		CHEMBL204171	75433	0	None	4	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	369	6	0	3	4.2	O=S(=O)(c1ccccc1)C1(CCCN2CCc3ccccc3C2)CCC1	10.1016/j.bmcl.2005.11.067
		90656693	112680	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay	ChEMBL	431	8	1	4	4.9	CN(C(=O)CCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262432	112680	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay	ChEMBL	431	8	1	4	4.9	CN(C(=O)CCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3304130	112680	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay	ChEMBL	431	8	1	4	4.9	CN(C(=O)CCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		90656693	112680	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	431	8	1	4	4.9	CN(C(=O)CCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262432	112680	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	431	8	1	4	4.9	CN(C(=O)CCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3304130	112680	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	431	8	1	4	4.9	CN(C(=O)CCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		5	139	72	None	-3	54	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
		5202	139	72	None	-3	54	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
		CHEMBL39	139	72	None	-3	54	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
		DB08839	139	72	None	-3	54	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
		10949445	165005	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	402	6	2	3	4.9	O=C1Nc2ccc(O)c3c2C1(CCCCN1CC=C(c2ccccc2)CC1)CCC3	10.1021/jm0104264
		CHEMBL422587	165005	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	402	6	2	3	4.9	O=C1Nc2ccc(O)c3c2C1(CCCCN1CC=C(c2ccccc2)CC1)CCC3	10.1021/jm0104264
		46203757	124547	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2c(C)cccc2C)cc1OC1CNC1	nan
		CHEMBL3640555	124547	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2c(C)cccc2C)cc1OC1CNC1	nan
		46203757	124547	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2c(C)cccc2C)cc1OC1CNC1	nan
		CHEMBL3640555	124547	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2c(C)cccc2C)cc1OC1CNC1	nan
		60196078	81805	2	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	268	3	1	3	2.8	COc1ccccc1-c1cccc(N2CCNCC2)c1	10.1021/jm3003679
		CHEMBL2164328	81805	2	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	268	3	1	3	2.8	COc1ccccc1-c1cccc(N2CCNCC2)c1	10.1021/jm3003679
		16006606	157661	3	None	-1	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	191	1	2	4	1.3	COc1cccc2c1N=C(N)NC2C	10.1016/j.bmcl.2007.10.080
		CHEMBL408152	157661	3	None	-1	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	191	1	2	4	1.3	COc1cccc2c1N=C(N)NC2C	10.1016/j.bmcl.2007.10.080
		24854040	161245	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccc(Cl)cc21	10.1021/jm070279v
		CHEMBL411919	161245	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccc(Cl)cc21	10.1021/jm070279v
		25107647	187484	0	None	11	3	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	453	8	0	3	5.6	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1Cc2ccccc2C1	10.1021/jm800615e
		CHEMBL494118	187484	0	None	11	3	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	453	8	0	3	5.6	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1Cc2ccccc2C1	10.1021/jm800615e
		44319435	206114	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	346	4	1	2	4.1	O=C1Nc2cccc3c2C1(CCCN1CCc2ccccc2C1)CCC3	10.1016/s0960-894x(02)00485-7
		CHEMBL85814	206114	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	346	4	1	2	4.1	O=C1Nc2cccc3c2C1(CCCN1CCc2ccccc2C1)CCC3	10.1016/s0960-894x(02)00485-7
		164609529	184464	0	None	-11	6	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	383	5	0	4	4.1	CC1(CCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O	10.1016/j.ejmech.2021.113243
		CHEMBL4846823	184464	0	None	-11	6	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	383	5	0	4	4.1	CC1(CCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O	10.1016/j.ejmech.2021.113243
		24964217	87214	0	None	63	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	255	5	0	2	3.5	COc1ccccc1-c1cccc(CCN(C)C)c1	10.1016/j.bmcl.2007.03.054
		CHEMBL232792	87214	0	None	63	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	255	5	0	2	3.5	COc1ccccc1-c1cccc(CCN(C)C)c1	10.1016/j.bmcl.2007.03.054
		132547279	142201	0	None	-2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	434	9	0	6	4.1	CCOc1ccccc1N1CCN(CCCCCn2c(C)nc3ccccc3c2=O)CC1	10.1016/j.bmc.2016.12.039
		CHEMBL3884095	142201	0	None	-2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	434	9	0	6	4.1	CCOc1ccccc1N1CCN(CCCCCn2c(C)nc3ccccc3c2=O)CC1	10.1016/j.bmc.2016.12.039
		118713688	114394	0	None	-40	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	439	10	0	6	4.8	COc1ccccc1N1CCN(CCCCCCCn2c(=O)sc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
		CHEMBL3331391	114394	0	None	-40	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	439	10	0	6	4.8	COc1ccccc1N1CCN(CCCCCCCn2c(=O)sc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
		CHEMBL5093342	215564	0	None	4	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		CHEMBL5095971	215564	0	None	4	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		164609529	184464	0	None	-11	6	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	383	5	0	4	4.1	CC1(CCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O	10.1016/j.ejmech.2021.113243
		CHEMBL4846823	184464	0	None	-11	6	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	383	5	0	4	4.1	CC1(CCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O	10.1016/j.ejmech.2021.113243
		10404657	98069	0	None	26	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	334	5	0	3	3.1	O=C1c2ccccc2C(=O)N1CCCCN1CCc2ccccc2C1	10.1016/j.bmc.2016.05.053
		CHEMBL273241	98069	0	None	26	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	334	5	0	3	3.1	O=C1c2ccccc2C(=O)N1CCCCN1CCc2ccccc2C1	10.1016/j.bmc.2016.05.053
		24963860	87213	0	None	562	3	Human	8.1	pKi	=	8.1	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	285	6	0	3	3.5	COc1cccc(OC)c1-c1cccc(CCN(C)C)c1	10.1016/j.ejmech.2019.111705
		CHEMBL232791	87213	0	None	562	3	Human	8.1	pKi	=	8.1	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	285	6	0	3	3.5	COc1cccc(OC)c1-c1cccc(CCN(C)C)c1	10.1016/j.ejmech.2019.111705
		10404657	98069	0	None	26	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	334	5	0	3	3.1	O=C1c2ccccc2C(=O)N1CCCCN1CCc2ccccc2C1	10.1016/j.bmc.2016.05.053
		CHEMBL273241	98069	0	None	26	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	334	5	0	3	3.1	O=C1c2ccccc2C(=O)N1CCCCN1CCc2ccccc2C1	10.1016/j.bmc.2016.05.053
		24963860	87213	0	None	562	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	285	6	0	3	3.5	COc1cccc(OC)c1-c1cccc(CCN(C)C)c1	10.1016/j.bmcl.2007.03.054
		CHEMBL232791	87213	0	None	562	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	285	6	0	3	3.5	COc1cccc(OC)c1-c1cccc(CCN(C)C)c1	10.1016/j.bmcl.2007.03.054
		25107580	187513	0	None	2	3	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	432	10	1	4	4.7	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	10.1021/jm800615e
		CHEMBL494312	187513	0	None	2	3	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	432	10	1	4	4.7	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	10.1021/jm800615e
		72550642	114078	0	None	2	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	491	10	1	4	5.6	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1	10.1016/j.bmc.2014.07.026
		CHEMBL3326982	114078	0	None	2	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	491	10	1	4	5.6	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1	10.1016/j.bmc.2014.07.026
		CHEMBL5093342	215564	0	None	4	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		CHEMBL5095971	215564	0	None	4	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		76325353	106420	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	411	5	0	4	5.3	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3C)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
		CHEMBL3121438	106420	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	411	5	0	4	5.3	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3C)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
		CHEMBL3139528	106420	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	411	5	0	4	5.3	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3C)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
		16093484	98060	6	None	-4	6	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	229	0	2	3	2.6	CC1NC(N)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.080
		CHEMBL273170	98060	6	None	-4	6	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	229	0	2	3	2.6	CC1NC(N)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.080
		10939416	204215	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	456	7	2	4	3.9	NC(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
		CHEMBL70889	204215	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	456	7	2	4	3.9	NC(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
		11729823	102971	1	None	-16	5	Human	8.1	pKi	=	8.1	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	437	5	0	2	4.6	O=C(c1ccc(F)cc1)C1CCN(CCc2cccc(I)c2)CC1	10.1021/jm0200411
		CHEMBL306478	102971	1	None	-16	5	Human	8.1	pKi	=	8.1	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	437	5	0	2	4.6	O=C(c1ccc(F)cc1)C1CCN(CCc2cccc(I)c2)CC1	10.1021/jm0200411
		66801028	112103	0	None	-2	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	501	8	1	6	4.4	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
		CHEMBL3289997	112103	0	None	-2	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	501	8	1	6	4.4	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
		6603866	97429	17	None	-39	9	Rat	8.1	pKi	=	8.1	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1	10.1021/jm9911433
		CHEMBL26998	97429	17	None	-39	9	Rat	8.1	pKi	=	8.1	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1	10.1021/jm9911433
		CHEMBL541268	97429	17	None	-39	9	Rat	8.1	pKi	=	8.1	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1	10.1021/jm9911433
		46204427	124566	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	293	3	1	2	4.0	Clc1ccc(-c2ccccc2Cl)cc1OC1CNC1	nan
		CHEMBL3640573	124566	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	293	3	1	2	4.0	Clc1ccc(-c2ccccc2Cl)cc1OC1CNC1	nan
		46204427	124566	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	293	3	1	2	4.0	Clc1ccc(-c2ccccc2Cl)cc1OC1CNC1	nan
		CHEMBL3640573	124566	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	293	3	1	2	4.0	Clc1ccc(-c2ccccc2Cl)cc1OC1CNC1	nan
		44327952	208044	0	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	367	5	3	3	2.6	CC[C@@](C)(CO)CNC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1021/jm030030n
		CHEMBL97518	208044	0	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	367	5	3	3	2.6	CC[C@@](C)(CO)CNC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1021/jm030030n
		21091965	68412	9	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	380	6	1	3	3.6	O=S(=O)(NCCCN1CCc2ccccc2C1)c1ccc2ccccc2c1	10.1016/j.bmc.2011.09.044
		CHEMBL1917333	68412	9	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	380	6	1	3	3.6	O=S(=O)(NCCCN1CCc2ccccc2C1)c1ccc2ccccc2c1	10.1016/j.bmc.2011.09.044
		60196075	81817	0	None	-5	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	239	2	1	3	2.2	c1ccc(-c2cccc(N3CCNCC3)c2)nc1	10.1021/jm3003679
		CHEMBL2164341	81817	0	None	-5	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	239	2	1	3	2.2	c1ccc(-c2cccc(N3CCNCC3)c2)nc1	10.1021/jm3003679
		66801528	156843	0	None	-5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	449	6	2	3	4.5	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
		CHEMBL4071451	156843	0	None	-5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	449	6	2	3	4.5	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
		66801052	158958	0	None	-18	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	461	8	2	3	4.8	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(F)cc1	10.1021/acs.jmedchem.7b00839
		CHEMBL4095979	158958	0	None	-18	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	461	8	2	3	4.8	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(F)cc1	10.1021/acs.jmedchem.7b00839
		3084440	159815	7	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	327	2	2	5	2.9	COc1cc2c(cc1O)-c1c(O)c(OC)cc3c1C(C2)N(C)CC3	10.1016/j.bmcl.2007.01.093
		CHEMBL410604	159815	7	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	327	2	2	5	2.9	COc1cc2c(cc1O)-c1c(O)c(OC)cc3c1C(C2)N(C)CC3	10.1016/j.bmcl.2007.01.093
		76518515	140870	0	None	-4	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	454	7	1	5	5.8	O=C(CCCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
		CHEMBL3818881	140870	0	None	-4	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	454	7	1	5	5.8	O=C(CCCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
		CHEMBL3819714	140870	0	None	-4	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	454	7	1	5	5.8	O=C(CCCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
		44401041	70487	0	None	-18	7	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	313	2	0	3	4.1	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL194659	70487	0	None	-18	7	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	313	2	0	3	4.1	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		46205698	124593	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	237	2	1	1	3.7	Cc1cccc(-c2ccccc2C2CCNC2)c1	nan
		CHEMBL3640599	124593	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	237	2	1	1	3.7	Cc1cccc(-c2ccccc2C2CCNC2)c1	nan
		46205698	124593	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	237	2	1	1	3.7	Cc1cccc(-c2ccccc2C2CCNC2)c1	nan
		CHEMBL3640599	124593	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	237	2	1	1	3.7	Cc1cccc(-c2ccccc2C2CCNC2)c1	nan
		155526014	171064	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	422	7	0	5	2.9	CCOc1ccccc1N1CCN(CCC(=O)N2CCN(c3ccccc3)CC2)CC1	10.1016/j.bmcl.2016.06.080
		CHEMBL4457095	171064	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	422	7	0	5	2.9	CCOc1ccccc1N1CCN(CCC(=O)N2CCN(c3ccccc3)CC2)CC1	10.1016/j.bmcl.2016.06.080
		44439387	91717	0	None	38	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	276	2	1	2	3.6	COc1cccc(C2=NCCc3c2[nH]c2ccccc32)c1	10.1016/j.bmcl.2007.01.093
		CHEMBL240888	91717	0	None	38	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	276	2	1	2	3.6	COc1cccc(C2=NCCc3c2[nH]c2ccccc32)c1	10.1016/j.bmcl.2007.01.093
		11773414	147285	0	None	-2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	380	4	1	4	4.2	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(O)CCCC3)CC2	10.1016/j.bmcl.2007.01.093
		CHEMBL392887	147285	0	None	-2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	380	4	1	4	4.2	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(O)CCCC3)CC2	10.1016/j.bmcl.2007.01.093
		1984087	162297	10	None	-2	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	351	9	1	3	5.3	COc1cc(CNCCC2=CCCCC2)ccc1OCc1ccccc1	10.1016/j.ejmech.2018.04.010
		CHEMBL4164250	162297	10	None	-2	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	351	9	1	3	5.3	COc1cc(CNCCC2=CCCCC2)ccc1OCc1ccccc1	10.1016/j.ejmech.2018.04.010
		135	2532	43	None	-83	58	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards rodent 5-hydroxytryptamine 7 receptorBinding affinity towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030030n
		1796	2532	43	None	-83	58	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards rodent 5-hydroxytryptamine 7 receptorBinding affinity towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030030n
		4184	2532	43	None	-83	58	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards rodent 5-hydroxytryptamine 7 receptorBinding affinity towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030030n
		CHEMBL6437	2532	43	None	-83	58	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards rodent 5-hydroxytryptamine 7 receptorBinding affinity towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030030n
		DB06148	2532	43	None	-83	58	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards rodent 5-hydroxytryptamine 7 receptorBinding affinity towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030030n
		24768526	93231	0	None	-41	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	422	8	1	4	3.2	O=C(CCCCCN1CCN(c2cccc[n+]2[O-])CC1)NC1CCCc2ccccc21	10.1021/jm070487n
		CHEMBL244792	93231	0	None	-41	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	422	8	1	4	3.2	O=C(CCCCCN1CCN(c2cccc[n+]2[O-])CC1)NC1CCCc2ccccc21	10.1021/jm070487n
		117209911	186329	1	None	5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
		CHEMBL4874854	186329	1	None	5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
		9992778	16259	0	None	-2	3	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	260	0	0	2	3.5	CN1CCc2ccc3ncc4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
		CHEMBL122453	16259	0	None	-2	3	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	260	0	0	2	3.5	CN1CCc2ccc3ncc4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
		90656673	110971	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	308	2	1	3	3.1	Oc1cccc2c1CC(N1CCN(c3ccccc3)CC1)CC2	10.1016/j.ejmech.2014.04.034
		CHEMBL3262398	110971	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	308	2	1	3	3.1	Oc1cccc2c1CC(N1CCN(c3ccccc3)CC1)CC2	10.1016/j.ejmech.2014.04.034
		130442480	175270	0	None	-100	24	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
		CHEMBL4572614	175270	0	None	-100	24	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
		18377415	206122	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	350	5	2	3	3.2	O=C1Nc2cccc3c2C1(CCCCN1CCc2n[nH]cc2C1)CCC3	10.1016/s0960-894x(02)00485-7
		CHEMBL85897	206122	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	350	5	2	3	3.2	O=C1Nc2cccc3c2C1(CCCCN1CCc2n[nH]cc2C1)CCC3	10.1016/s0960-894x(02)00485-7
		71453156	81170	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	422	6	1	3	5.3	Cc1ccccc1C(=O)NC1CCN(CCSc2cccc(Cl)c2Cl)CC1	10.1016/j.ejmech.2012.07.043
		CHEMBL2158036	81170	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	422	6	1	3	5.3	Cc1ccccc1C(=O)NC1CCN(CCSc2cccc(Cl)c2Cl)CC1	10.1016/j.ejmech.2012.07.043
		24768521	93012	0	None	-19	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	420	8	2	4	4.1	Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
		CHEMBL244162	93012	0	None	-19	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	420	8	2	4	4.1	Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
		11178340	84695	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	446	8	1	5	4.7	O=C(CCCCCN1CCN(c2nc3ccccc3o2)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
		CHEMBL222604	84695	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	446	8	1	5	4.7	O=C(CCCCCN1CCN(c2nc3ccccc3o2)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
		155520499	170484	0	None	-3	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	494	9	0	6	4.6	O=[N+]([O-])c1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/j.bmcl.2019.06.029
		CHEMBL4449148	170484	0	None	-3	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	494	9	0	6	4.6	O=[N+]([O-])c1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/j.bmcl.2019.06.029
		145986720	167243	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	436	7	2	5	2.1	CC1(C)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1039/C8MD00168E
		CHEMBL4292541	167243	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	436	7	2	5	2.1	CC1(C)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1039/C8MD00168E
		CHEMBL4777443	214046	0	None	-39	14	Human	6.1	pKi	=	6.1	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000741a HTR7Selectivity interaction (GPCR panel (PDSP screen)) EUB0000741a HTR7	ChEMBL		None	None	None		CC(C)(C)OC(=O)N1CCCC1CN[C@H]1CC[C@@](c2cc(F)ccc2F)(S(=O)(=O)c2ccc(Cl)cc2)CC1	10.6019/CHEMBL5212743
		58405078	110696	0	None	2	4	Rat	7.1	pKi	=	7.1	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	310	5	1	5	3.0	Cc1nc(COc2ccc(Cl)cc2OC2CNC2)cs1	10.1021/ml500082j
		CHEMBL3260335	110696	0	None	2	4	Rat	7.1	pKi	=	7.1	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	310	5	1	5	3.0	Cc1nc(COc2ccc(Cl)cc2OC2CNC2)cs1	10.1021/ml500082j
		1342	35	49	None	-33	19	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	10.1021/jm030030n
		3	35	49	None	-33	19	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	10.1021/jm030030n
		CHEMBL277120	35	49	None	-33	19	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	10.1021/jm030030n
		44327952	208044	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	367	5	3	3	2.6	CC[C@@](C)(CO)CNC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1021/jm030030n
		CHEMBL97518	208044	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	367	5	3	3	2.6	CC[C@@](C)(CO)CNC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1021/jm030030n
		44424665	85716	0	None	5	2	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	411	7	0	8	1.7	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCc2ccccc2C1	10.1016/j.bmc.2007.05.017
		CHEMBL228882	85716	0	None	5	2	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	411	7	0	8	1.7	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCc2ccccc2C1	10.1016/j.bmc.2007.05.017
		1342	35	49	None	-13	19	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells	ChEMBL	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	10.1021/jm3003679
		3	35	49	None	-13	19	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells	ChEMBL	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	10.1021/jm3003679
		CHEMBL277120	35	49	None	-13	19	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells	ChEMBL	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	10.1021/jm3003679
		122483212	138097	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	376	6	0	3	6.0	CC1CC(C)CN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
		CHEMBL3763858	138097	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	376	6	0	3	6.0	CC1CC(C)CN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
		CHEMBL3765845	138097	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	376	6	0	3	6.0	CC1CC(C)CN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
		122483212	138097	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	376	6	0	3	6.0	CC1CC(C)CN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
		CHEMBL3763858	138097	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	376	6	0	3	6.0	CC1CC(C)CN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
		CHEMBL3765845	138097	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	376	6	0	3	6.0	CC1CC(C)CN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
		155543653	173195	0	None	-70	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	348	4	1	7	2.0	CC(Oc1cccc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
		CHEMBL4522568	173195	0	None	-70	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	348	4	1	7	2.0	CC(Oc1cccc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
		127028799	138238	0	None	6	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	444	6	2	5	1.9	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(F)cc3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
		CHEMBL3770293	138238	0	None	6	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	444	6	2	5	1.9	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(F)cc3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
		435595	55302	14	None	10	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	238	4	0	4	3.0	CN(C)CCSc1nc2ccccc2s1	10.1016/j.bmcl.2003.11.050
		CHEMBL161846	55302	14	None	10	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	238	4	0	4	3.0	CN(C)CCSc1nc2ccccc2s1	10.1016/j.bmcl.2003.11.050
		129211	3749	78	None	-151	15	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm9905918
		2562	3749	78	None	-151	15	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm9905918
		488	3749	78	None	-151	15	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm9905918
		CHEMBL836	3749	78	None	-151	15	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm9905918
		DB00706	3749	78	None	-151	15	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm9905918
		127038282	137082	0	None	67	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	420	7	1	6	2.5	Cn1cc(S(=O)(=O)NC2CCN(CCOc3ccccc3C(C)(C)C)CC2)cn1	10.1016/j.ejmech.2015.11.040
		CHEMBL3747117	137082	0	None	67	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	420	7	1	6	2.5	Cn1cc(S(=O)(=O)NC2CCN(CCOc3ccccc3C(C)(C)C)CC2)cn1	10.1016/j.ejmech.2015.11.040
		155567307	175942	0	None	-7	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	457	10	0	4	5.6	CCOc1ccccc1N1CCN(CCCCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1016/j.bmcl.2019.06.029
		CHEMBL4587772	175942	0	None	-7	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	457	10	0	4	5.6	CCOc1ccccc1N1CCN(CCCCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1016/j.bmcl.2019.06.029
		156013695	177270	0	None	-4	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	285	2	0	1	4.4	CN(C)[C@@H]1CCc2c(cccc2-c2ccc(Cl)cc2)C1	10.1016/j.bmc.2019.115262
		CHEMBL4636210	177270	0	None	-4	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	285	2	0	1	4.4	CN(C)[C@@H]1CCc2c(cccc2-c2ccc(Cl)cc2)C1	10.1016/j.bmc.2019.115262
		90656678	110979	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	323	6	0	3	3.6	Cc1cccc(N(C)CCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262412	110979	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	323	6	0	3	3.6	Cc1cccc(N(C)CCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
		44414722	80354	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	296	5	1	3	2.9	COc1ccccc1CC(c1ccccc1)N1CCNCC1	10.1016/j.bmcl.2010.04.052
		CHEMBL214335	80354	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	296	5	1	3	2.9	COc1ccccc1CC(c1ccccc1)N1CCNCC1	10.1016/j.bmcl.2010.04.052
		2477	745	59	None	-128	29	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1016/j.bmc.2019.115262
		36	745	59	None	-128	29	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1016/j.bmc.2019.115262
		437	745	59	None	-128	29	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1016/j.bmc.2019.115262
		CHEMBL49	745	59	None	-128	29	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1016/j.bmc.2019.115262
		DB00490	745	59	None	-128	29	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1016/j.bmc.2019.115262
		2928642	162289	9	None	-3	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	353	7	1	2	6.1	Cc1ccc(C(CCNC(C)c2ccc(Cl)cc2)c2ccco2)cc1	10.1016/j.ejmech.2018.04.010
		CHEMBL4164143	162289	9	None	-3	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	353	7	1	2	6.1	Cc1ccc(C(CCNC(C)c2ccc(Cl)cc2)c2ccco2)cc1	10.1016/j.ejmech.2018.04.010
		2962174	162971	10	None	-44	2	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	410	5	1	4	4.2	O=C1N(Cc2ccccc2)C(c2ccccc2)=NC1(Nc1ccccn1)C(F)(F)F	10.1016/j.ejmech.2018.04.010
		CHEMBL4174981	162971	10	None	-44	2	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	410	5	1	4	4.2	O=C1N(Cc2ccccc2)C(c2ccccc2)=NC1(Nc1ccccn1)C(F)(F)F	10.1016/j.ejmech.2018.04.010
		44276170	96317	0	None	-25	4	Rat	7.1	pKi	=	7.1	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	382	9	0	5	3.9	COc1cccc(C(=O)CCCCN2CCN(c3ccccc3OC)CC2)c1	10.1021/jm020994z
		CHEMBL26135	96317	0	None	-25	4	Rat	7.1	pKi	=	7.1	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	382	9	0	5	3.9	COc1cccc(C(=O)CCCCN2CCN(c3ccccc3OC)CC2)c1	10.1021/jm020994z
		71456770	81365	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	430	9	1	4	4.6	CCOc1ccccc1C(=O)NC1CCN(CCOc2ccccc2-c2ccccc2)C1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159313	81365	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	430	9	1	4	4.6	CCOc1ccccc1C(=O)NC1CCN(CCOc2ccccc2-c2ccccc2)C1	10.1016/j.ejmech.2012.07.043
		145946620	167556	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3cccc(F)c3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
		CHEMBL4174681	167556	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3cccc(F)c3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
		CHEMBL4300388	167556	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3cccc(F)c3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
		155548275	173789	0	None	-79	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	426	5	2	5	4.1	CCC(=O)Nc1nc(C)c(-c2cn(S(=O)(=O)c3ccccc3)c3ccc(F)cc23)[nH]1	10.1016/j.ejmech.2019.06.001
		CHEMBL4537701	173789	0	None	-79	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	426	5	2	5	4.1	CCC(=O)Nc1nc(C)c(-c2cn(S(=O)(=O)c3ccccc3)c3ccc(F)cc23)[nH]1	10.1016/j.ejmech.2019.06.001
		144950987	179970	0	None	-707	6	Human	4.1	pKi	=	4.1	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	292	3	0	2	3.4	CN(C)CCN1C(=O)c2ccccc2/C=C\c2ccccc21	10.1016/j.bmcl.2020.127493
		CHEMBL4746800	179970	0	None	-707	6	Human	4.1	pKi	=	4.1	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	292	3	0	2	3.4	CN(C)CCN1C(=O)c2ccccc2/C=C\c2ccccc21	10.1016/j.bmcl.2020.127493
		37219401	137830	4	None	2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	378	7	1	4	2.6	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2015.11.040
		CHEMBL3759874	137830	4	None	2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	378	7	1	4	2.6	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2015.11.040
		164618100	185360	0	None	-128	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	5	1	7	3.0	CCC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
		CHEMBL4860275	185360	0	None	-128	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	5	1	7	3.0	CCC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
		164612518	185394	0	None	-41	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	6	1	7	2.5	CN1CCN(c2nc(N)nc(CCCOc3cccc(Cl)c3Cl)n2)CC1	10.1016/j.ejmech.2020.112529
		CHEMBL4860719	185394	0	None	-41	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	6	1	7	2.5	CN1CCN(c2nc(N)nc(CCCOc3cccc(Cl)c3Cl)n2)CC1	10.1016/j.ejmech.2020.112529
		122483275	138110	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3764133	138110	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765875	138110	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		145975289	163579	0	None	16	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	472	7	1	4	3.9	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1cccc(Cl)c1	10.1021/acs.jmedchem.8b00828
		CHEMBL4203295	163579	0	None	16	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	472	7	1	4	3.9	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1cccc(Cl)c1	10.1021/acs.jmedchem.8b00828
		122483275	138110	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3764133	138110	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765875	138110	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		127050699	140872	0	None	1	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	3	0	1	4.0	Fc1ccc2c(c1)CC(CCN1CCc3ccccc3C1)C2	10.1016/j.bmc.2016.05.053
		CHEMBL3819082	140872	0	None	1	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	3	0	1	4.0	Fc1ccc2c(c1)CC(CCN1CCc3ccccc3C1)C2	10.1016/j.bmc.2016.05.053
		CHEMBL3819726	140872	0	None	1	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	3	0	1	4.0	Fc1ccc2c(c1)CC(CCN1CCc3ccccc3C1)C2	10.1016/j.bmc.2016.05.053
		21071390	1987	53	None	-10471	7	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	398	9	2	2	4.9	Fc1ccc2c(c1)[nH]cc2CCNCc1cccc(c1)OCC(C(F)F)(F)F	10.1016/j.ejmech.2019.111857
		8689	1987	53	None	-10471	7	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	398	9	2	2	4.9	Fc1ccc2c(c1)[nH]cc2CCNCc1cccc(c1)OCC(C(F)F)(F)F	10.1016/j.ejmech.2019.111857
		CHEMBL3286580	1987	53	None	-10471	7	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	398	9	2	2	4.9	Fc1ccc2c(c1)[nH]cc2CCNCc1cccc(c1)OCC(C(F)F)(F)F	10.1016/j.ejmech.2019.111857
		DB11957	1987	53	None	-10471	7	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	398	9	2	2	4.9	Fc1ccc2c(c1)[nH]cc2CCNCc1cccc(c1)OCC(C(F)F)(F)F	10.1016/j.ejmech.2019.111857
		42618255	181576	0	None	-1	2	Human	6.1	pKi	=	6.1	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	428	6	0	6	3.6	COc1cccc(-n2c(=O)n(CCN3CCN(c4ccccc4)CC3)c3ccccc32)c1	10.1016/j.bmcl.2009.02.008
		CHEMBL476862	181576	0	None	-1	2	Human	6.1	pKi	=	6.1	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	428	6	0	6	3.6	COc1cccc(-n2c(=O)n(CCN3CCN(c4ccccc4)CC3)c3ccccc32)c1	10.1016/j.bmcl.2009.02.008
		71454898	81159	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	467	7	1	4	5.9	O=C(NC1CCN(CCSc2ccccc2-c2ccccc2)CC1)c1ccc2ccccc2n1	10.1016/j.ejmech.2012.07.043
		CHEMBL2158025	81159	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	467	7	1	4	5.9	O=C(NC1CCN(CCSc2ccccc2-c2ccccc2)CC1)c1ccc2ccccc2n1	10.1016/j.ejmech.2012.07.043
		162671167	183757	0	None	-3	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	397	9	1	5	2.9	COc1ccccc1CNC(=O)CCCN1CCN(c2ccccc2OC)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4790826	183757	0	None	-3	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	397	9	1	5	2.9	COc1ccccc1CNC(=O)CCCN1CCN(c2ccccc2OC)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4803803	183757	0	None	-3	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	397	9	1	5	2.9	COc1ccccc1CNC(=O)CCCN1CCN(c2ccccc2OC)CC1	10.1016/j.ejmech.2020.112437
		56850926	71489	0	None	-67	2	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	362	9	1	5	3.2	O=C1CSC(=O)N1CCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
		CHEMBL1926759	71489	0	None	-67	2	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	362	9	1	5	3.2	O=C1CSC(=O)N1CCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
		CHEMBL1962491	71489	0	None	-67	2	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	362	9	1	5	3.2	O=C1CSC(=O)N1CCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
		134142907	145299	0	None	39	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	469	10	1	6	3.5	N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3cccnc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		CHEMBL3913100	145299	0	None	39	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	469	10	1	6	3.5	N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3cccnc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
		4431	2729	25	None	-20	12	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	393	7	0	5	2.9	COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2	10.1016/j.ejmech.2021.113931
		73	2729	25	None	-20	12	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	393	7	0	5	2.9	COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2	10.1016/j.ejmech.2021.113931
		CHEMBL8618	2729	25	None	-20	12	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	393	7	0	5	2.9	COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2	10.1016/j.ejmech.2021.113931
		118706290	120533	0	None	-128	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1C(O)c1cc(C(=O)N=C(N)N)ccc1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3310116	120533	0	None	-128	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1C(O)c1cc(C(=O)N=C(N)N)ccc1-2	10.1016/j.bmc.2014.05.027
		CHEMBL3545468	120533	0	None	-128	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1C(O)c1cc(C(=O)N=C(N)N)ccc1-2	10.1016/j.bmc.2014.05.027
		4431	2729	25	None	-251	12	Rat	7.1	pKi	=	7.1	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	393	7	0	5	2.9	COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2	10.1016/j.bmcl.2004.09.029
		73	2729	25	None	-251	12	Rat	7.1	pKi	=	7.1	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	393	7	0	5	2.9	COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2	10.1016/j.bmcl.2004.09.029
		CHEMBL8618	2729	25	None	-251	12	Rat	7.1	pKi	=	7.1	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	393	7	0	5	2.9	COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2	10.1016/j.bmcl.2004.09.029
		15629493	202046	1	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	233	4	0	2	2.9	CCN(CC)[C@@H]1CCc2cccc(OC)c2C1	10.1021/jm030826m
		CHEMBL608536	202046	1	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	233	4	0	2	2.9	CCN(CC)[C@@H]1CCc2cccc(OC)c2C1	10.1021/jm030826m
		122483275	138110	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3764133	138110	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765875	138110	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		3037629	184572	18	None	-21	10	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay	ChEMBL	396	5	1	5	3.6	C=C[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
		CHEMBL4848517	184572	18	None	-21	10	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay	ChEMBL	396	5	1	5	3.6	C=C[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
		52952421	62582	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	479	6	1	6	5.5	O=[N+]([O-])c1ccc(N2CCCN(CCC(O)c3csc4ccccc34)CC2)c(C(F)(F)F)c1	10.1021/jm2000773
		CHEMBL1782795	62582	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	479	6	1	6	5.5	O=[N+]([O-])c1ccc(N2CCCN(CCC(O)c3csc4ccccc34)CC2)c(C(F)(F)F)c1	10.1021/jm2000773
		51352628	82827	10	None	-4	3	Human	5.1	pKi	=	5.1	Binding	GPCRScan assay: inhibition of 5-HT7AGPCRScan assay: inhibition of 5-HT7A	ChEMBL	353	5	0	7	2.1	COCCc1ccc(-c2c(C)nc3c(N4CCOCC4)ccnn23)cn1	10.6019/CHEMBL4800727
		CHEMBL2180408	82827	10	None	-4	3	Human	5.1	pKi	=	5.1	Binding	GPCRScan assay: inhibition of 5-HT7AGPCRScan assay: inhibition of 5-HT7A	ChEMBL	353	5	0	7	2.1	COCCc1ccc(-c2c(C)nc3c(N4CCOCC4)ccnn23)cn1	10.6019/CHEMBL4800727
		155530779	171570	0	None	-11	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	376	8	2	4	4.8	COc1cccc(-c2ccc(CNCCc3c[nH]c4ccc(OC)cc34)o2)c1	10.1016/j.ejmech.2019.111857
		CHEMBL4464881	171570	0	None	-11	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	376	8	2	4	4.8	COc1cccc(-c2ccc(CNCCc3c[nH]c4ccc(OC)cc34)o2)c1	10.1016/j.ejmech.2019.111857
		71462068	81173	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	443	6	1	4	4.8	O=C(NC1CCN(CCOc2cc(Cl)ccc2Cl)CC1)c1ccc2ccccc2n1	10.1016/j.ejmech.2012.07.043
		CHEMBL2158039	81173	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	443	6	1	4	4.8	O=C(NC1CCN(CCOc2cc(Cl)ccc2Cl)CC1)c1ccc2ccccc2n1	10.1016/j.ejmech.2012.07.043
		51352628	82827	10	None	-4	3	Human	5.1	pKi	=	5.1	Binding	GPCRScan assay: inhibition of 5-HT7AGPCRScan assay: inhibition of 5-HT7A	ChEMBL	353	5	0	7	2.1	COCCc1ccc(-c2c(C)nc3c(N4CCOCC4)ccnn23)cn1	10.6019/CHEMBL4800727
		CHEMBL2180408	82827	10	None	-4	3	Human	5.1	pKi	=	5.1	Binding	GPCRScan assay: inhibition of 5-HT7AGPCRScan assay: inhibition of 5-HT7A	ChEMBL	353	5	0	7	2.1	COCCc1ccc(-c2c(C)nc3c(N4CCOCC4)ccnn23)cn1	10.6019/CHEMBL4800727
		126720394	162314	0	None	-1230	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	355	4	1	5	3.1	CCc1nc2c(N3CCNCC3)ccnc2n1Cc1cccc(Cl)c1	10.1016/j.ejmech.2017.12.053
		CHEMBL4164541	162314	0	None	-1230	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	355	4	1	5	3.1	CCc1nc2c(N3CCNCC3)ccnc2n1Cc1cccc(Cl)c1	10.1016/j.ejmech.2017.12.053
		10421583	99183	1	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	235	0	0	1	3.4	CN1CCc2cccc3c2[C@H]1Cc1ccccc1-3	10.1021/jm9911433
		CHEMBL281357	99183	1	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	235	0	0	1	3.4	CN1CCc2cccc3c2[C@H]1Cc1ccccc1-3	10.1021/jm9911433
		44460808	205547	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	335	3	0	3	3.0	CN1CCCN(CCn2ccc3cc(Br)ccc32)CC1	10.1016/s0960-894x(02)00438-9
		CHEMBL81041	205547	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	335	3	0	3	3.0	CN1CCCN(CCn2ccc3cc(Br)ccc32)CC1	10.1016/s0960-894x(02)00438-9
		21092408	68427	0	None	3	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	395	7	1	4	3.4	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1cccc2cccnc12	10.1016/j.bmc.2011.09.044
		CHEMBL1917348	68427	0	None	3	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	395	7	1	4	3.4	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1cccc2cccnc12	10.1016/j.bmc.2011.09.044
		57395084	71551	0	None	1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccc(Cl)cc2c1	10.1016/j.bmc.2011.12.039
		CHEMBL1949964	71551	0	None	1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccc(Cl)cc2c1	10.1016/j.bmc.2011.12.039
		CHEMBL1963027	71551	0	None	1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccc(Cl)cc2c1	10.1016/j.bmc.2011.12.039
		10421583	99183	1	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	235	0	0	1	3.4	CN1CCc2cccc3c2[C@H]1Cc1ccccc1-3	10.1021/jm0108505
		CHEMBL281357	99183	1	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	235	0	0	1	3.4	CN1CCc2cccc3c2[C@H]1Cc1ccccc1-3	10.1021/jm0108505
		118728528	117724	0	None	-27	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	444	7	0	6	4.7	Cc1sc2ncn(CCCCCN3CCN(c4cccc(Cl)c4)CC3)c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
		CHEMBL3401491	117724	0	None	-27	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	444	7	0	6	4.7	Cc1sc2ncn(CCCCCN3CCN(c4cccc(Cl)c4)CC3)c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
		135367404	164555	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
		CHEMBL4215197	164555	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
		118709751	113541	0	None	-691	10	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccccc1F	10.1016/j.bmcl.2014.07.018
		CHEMBL3321792	113541	0	None	-691	10	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccccc1F	10.1016/j.bmcl.2014.07.018
		122483249	138094	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.3	CC1CCCN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
		CHEMBL3764970	138094	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.3	CC1CCCN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
		CHEMBL3765842	138094	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.3	CC1CCCN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
		135367817	163555	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
		CHEMBL4202995	163555	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
		32354149	164393	0	None	2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	374	7	1	4	2.8	Cc1cccc(OCCN2CCC(NS(=O)(=O)c3ccccc3)CC2)c1	10.1021/acs.jmedchem.8b00828
		CHEMBL4213238	164393	0	None	2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	374	7	1	4	2.8	Cc1cccc(OCCN2CCC(NS(=O)(=O)c3ccccc3)CC2)c1	10.1021/acs.jmedchem.8b00828
		47556338	166813	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	397	5	2	4	2.0	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCc3ccccc3C2)C1=O	10.1039/C8MD00168E
		CHEMBL4284656	166813	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	397	5	2	4	2.0	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCc3ccccc3C2)C1=O	10.1039/C8MD00168E
		9843889	16306	0	None	1	2	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from from 5-HT7 receptor in rat hypothalamus membranes by Cheng-Prusoff equation analysisDisplacement of [3H]-5-CT from from 5-HT7 receptor in rat hypothalamus membranes by Cheng-Prusoff equation analysis	ChEMBL	399	7	0	3	4.8	O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1021/acs.jmedchem.7b01898
		CHEMBL12259	16306	0	None	1	2	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from from 5-HT7 receptor in rat hypothalamus membranes by Cheng-Prusoff equation analysisDisplacement of [3H]-5-CT from from 5-HT7 receptor in rat hypothalamus membranes by Cheng-Prusoff equation analysis	ChEMBL	399	7	0	3	4.8	O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1021/acs.jmedchem.7b01898
		127028153	138163	0	None	33	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	456	7	2	6	1.8	COc1cccc(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1	10.1016/j.ejmech.2016.02.024
		CHEMBL3769441	138163	0	None	33	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	456	7	2	6	1.8	COc1cccc(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1	10.1016/j.ejmech.2016.02.024
		156015769	177579	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	388	4	1	5	2.8	COc1cc2c3c(c1OC)-c1cc(NS(C)(=O)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
		CHEMBL4640588	177579	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	388	4	1	5	2.8	COc1cc2c3c(c1OC)-c1cc(NS(C)(=O)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
		9843889	16306	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	399	7	0	3	4.8	O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
		CHEMBL12259	16306	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	399	7	0	3	4.8	O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
		9843889	16306	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	399	7	0	3	4.8	O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1021/jm8014553
		CHEMBL12259	16306	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	399	7	0	3	4.8	O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1021/jm8014553
		145946714	167558	0	None	-6	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2cc(C)cc(C)c2C)CC1	10.1016/j.bmcl.2018.04.059
		CHEMBL4213352	167558	0	None	-6	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2cc(C)cc(C)c2C)CC1	10.1016/j.bmcl.2018.04.059
		CHEMBL4300399	167558	0	None	-6	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2cc(C)cc(C)c2C)CC1	10.1016/j.bmcl.2018.04.059
		50878551	90745	61	None	1	18	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2015.12.053
		CHEMBL2391541	90745	61	None	1	18	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2015.12.053
		242	470	124	None	-14	51	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2020.112709
		34	470	124	None	-14	51	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2020.112709
		60795	470	124	None	-14	51	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2020.112709
		CHEMBL1112	470	124	None	-14	51	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2020.112709
		DB01238	470	124	None	-14	51	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2020.112709
		135367817	163555	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
		CHEMBL4202995	163555	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
		135367404	164555	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
		CHEMBL4215197	164555	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
		155512487	169669	3	None	-446	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	350	6	3	3	4.6	Oc1ccc(-c2ccc(CNCCc3c[nH]c4ccc(F)cc34)o2)cc1	10.1016/j.ejmech.2019.111857
		CHEMBL4437523	169669	3	None	-446	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	350	6	3	3	4.6	Oc1ccc(-c2ccc(CNCCc3c[nH]c4ccc(F)cc34)o2)cc1	10.1016/j.ejmech.2019.111857
		12088082	65126	0	None	17	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	353	7	3	7	2.8	C[C@H](Nc1nc(N)nc(NCCc2ccccn2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
		CHEMBL182418	65126	0	None	17	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	353	7	3	7	2.8	C[C@H](Nc1nc(N)nc(NCCc2ccccn2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
		44461048	168162	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	375	5	0	3	3.8	Brc1ccc2ccn(CCN3CCCN(CC4CC4)CC3)c2c1	10.1016/s0960-894x(02)00438-9
		CHEMBL433134	168162	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	375	5	0	3	3.8	Brc1ccc2ccn(CCN3CCCN(CC4CC4)CC3)c2c1	10.1016/s0960-894x(02)00438-9
		135398737	958	93	None	-13	89	Human	8.1	pKi	=	8.1	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm990550b
		38	958	93	None	-13	89	Human	8.1	pKi	=	8.1	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm990550b
		722	958	93	None	-13	89	Human	8.1	pKi	=	8.1	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm990550b
		CHEMBL42	958	93	None	-13	89	Human	8.1	pKi	=	8.1	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm990550b
		DB00363	958	93	None	-13	89	Human	8.1	pKi	=	8.1	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm990550b
		127025244	137755	0	None	11	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	464	8	1	4	4.4	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2ccc(F)c(F)c2)C3)c1	10.1016/j.ejmech.2015.11.040
		CHEMBL3759262	137755	0	None	11	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	464	8	1	4	4.4	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2ccc(F)c(F)c2)C3)c1	10.1016/j.ejmech.2015.11.040
		127041244	137072	0	None	6	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	416	8	0	4	4.0	CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2ccccc2)CC1	10.1016/j.bmc.2015.11.041
		CHEMBL3747052	137072	0	None	6	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	416	8	0	4	4.0	CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2ccccc2)CC1	10.1016/j.bmc.2015.11.041
		145984299	165752	0	None	-63	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4246655	165752	0	None	-63	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
		71456782	81436	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	364	7	1	4	2.3	O=S(=O)(NC1CCN(CCOc2ccccc2)C1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159479	81436	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	364	7	1	4	2.3	O=S(=O)(NC1CCN(CCOc2ccccc2)C1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
		71453280	81440	0	None	1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	458	8	1	4	4.1	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1cc(F)ccc1F	10.1016/j.ejmech.2012.07.043
		CHEMBL2159483	81440	0	None	1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	458	8	1	4	4.1	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1cc(F)ccc1F	10.1016/j.ejmech.2012.07.043
		118731363	118199	0	None	4	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	566	8	0	5	4.5	O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCOCC1	10.1016/j.ejmech.2014.12.041
		CHEMBL3409046	118199	0	None	4	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	566	8	0	5	4.5	O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCOCC1	10.1016/j.ejmech.2014.12.041
		118731364	118200	0	None	2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	578	9	0	4	6.0	O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
		CHEMBL3409047	118200	0	None	2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	578	9	0	4	6.0	O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
		118731366	118202	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	594	10	0	5	5.2	O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCOCC1	10.1016/j.ejmech.2014.12.041
		CHEMBL3409049	118202	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	594	10	0	5	5.2	O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCOCC1	10.1016/j.ejmech.2014.12.041
		145947456	167650	0	None	33	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	467	6	2	6	2.2	CC1(c2ccc(Cl)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2018.01.093
		CHEMBL4174055	167650	0	None	33	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	467	6	2	6	2.2	CC1(c2ccc(Cl)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2018.01.093
		CHEMBL4301717	167650	0	None	33	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	467	6	2	6	2.2	CC1(c2ccc(Cl)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2018.01.093
		156017281	177665	0	None	-8	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	466	8	0	6	4.0	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
		CHEMBL4641609	177665	0	None	-8	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	466	8	0	6	4.0	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
		122377930	136652	0	None	11	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	420	8	1	4	3.8	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(F)c2)CC1	10.1039/C5MD00166H
		CHEMBL3740054	136652	0	None	11	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	420	8	1	4	3.8	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(F)c2)CC1	10.1039/C5MD00166H
		127041107	136801	0	None	8	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	487	8	1	5	4.7	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cncc2ccccc12	10.1039/C5MD00166H
		CHEMBL3741445	136801	0	None	8	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	487	8	1	5	4.7	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cncc2ccccc12	10.1039/C5MD00166H
		11460460	182362	0	None	-8	4	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	289	2	1	3	3.5	CC(C)n1nc2c(c1-c1ccc(Cl)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
		CHEMBL4784845	182362	0	None	-8	4	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	289	2	1	3	3.5	CC(C)n1nc2c(c1-c1ccc(Cl)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
		66800947	158233	0	None	-8	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	433	6	2	3	4.0	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(F)cc1	10.1021/acs.jmedchem.7b00839
		CHEMBL4088249	158233	0	None	-8	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	433	6	2	3	4.0	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(F)cc1	10.1021/acs.jmedchem.7b00839
		11397799	84733	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	421	8	1	4	4.2	COc1ccccc1N1CCN(CCCCC(=O)NC2CCCc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
		CHEMBL222864	84733	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	421	8	1	4	4.2	COc1ccccc1N1CCN(CCCCC(=O)NC2CCCc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
		11326570	76720	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	383	7	0	3	4.7	O=S(=O)(c1ccccc1)C1(CCCN2CCC(c3ccccc3)C2)CCC1	10.1016/j.bmcl.2005.11.067
		CHEMBL206563	76720	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	383	7	0	3	4.7	O=S(=O)(c1ccccc1)C1(CCCN2CCC(c3ccccc3)C2)CCC1	10.1016/j.bmcl.2005.11.067
		44326733	111629	0	None	512	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	306	2	2	3	3.3	c1ccc2c3c([nH]c2c1)C(Cc1ccc2c(c1)OCO2)NCC3	10.1016/j.bmcl.2007.01.093
		CHEMBL328476	111629	0	None	512	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	306	2	2	3	3.3	c1ccc2c3c([nH]c2c1)C(Cc1ccc2c(c1)OCO2)NCC3	10.1016/j.bmcl.2007.01.093
		66801605	112065	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	520	8	1	7	5.0	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
		CHEMBL3289960	112065	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	520	8	1	7	5.0	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
		25107579	187442	0	None	-1	3	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	436	10	1	5	4.3	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	10.1021/jm800615e
		CHEMBL493909	187442	0	None	-1	3	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	436	10	1	5	4.3	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	10.1021/jm800615e
		24854266	96250	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2cc(F)c(Cl)cc21	10.1021/jm200547z
		CHEMBL261009	96250	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2cc(F)c(Cl)cc21	10.1021/jm200547z
		24854266	96250	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2cc(F)c(Cl)cc21	10.1021/jm070279v
		CHEMBL261009	96250	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2cc(F)c(Cl)cc21	10.1021/jm070279v
		155567476	175898	0	None	251	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	450	7	1	6	4.4	O=c1[nH]c(SCCCN2CCN(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
		CHEMBL4586787	175898	0	None	251	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	450	7	1	6	4.4	O=c1[nH]c(SCCCN2CCN(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
		10324985	76781	8	None	-6	17	Human	8.0	pKi	=	8.0	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
		CHEMBL199824	76781	8	None	-6	17	Human	8.0	pKi	=	8.0	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
		CHEMBL2068762	76781	8	None	-6	17	Human	8.0	pKi	=	8.0	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
		44266244	208072	0	None	6	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	378	5	0	3	3.9	Cc1ccc(OC2CCN(CCN3CCCc4ccccc4C3=O)CC2)cc1	10.1016/s0960-894x(03)00077-5
		CHEMBL9770	208072	0	None	6	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	378	5	0	3	3.9	Cc1ccc(OC2CCN(CCN3CCCc4ccccc4C3=O)CC2)cc1	10.1016/s0960-894x(03)00077-5
		CHEMBL5074880	214339	0	None	1	9	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		44266164	207186	0	None	19	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	423	4	0	5	3.5	O=C1c2ccccc2CCCN1CCN1CCC(n2c(=O)oc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
		CHEMBL9250	207186	0	None	19	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	423	4	0	5	3.5	O=C1c2ccccc2CCCN1CCN1CCC(n2c(=O)oc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
		155515687	169970	0	None	-2	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	452	6	1	5	4.9	O=c1[nH]c(CCCCN2CCN(c3cccc(Cl)c3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
		CHEMBL4441943	169970	0	None	-2	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	452	6	1	5	4.9	O=c1[nH]c(CCCCN2CCN(c3cccc(Cl)c3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
		24854270	95854	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	479	7	1	3	6.2	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2c(Cl)cc(Cl)cc21	10.1021/jm070279v
		CHEMBL259009	95854	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	479	7	1	3	6.2	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2c(Cl)cc(Cl)cc21	10.1021/jm070279v
		134136134	144437	0	None	6	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	584	15	1	6	5.5	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccc(OCCCN2CCOCC2)cc1	10.1016/j.ejmech.2016.05.005
		CHEMBL3906408	144437	0	None	6	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	584	15	1	6	5.5	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccc(OCCCN2CCOCC2)cc1	10.1016/j.ejmech.2016.05.005
		156020950	178122	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	251	2	0	1	3.8	CN(C)[C@H]1CCc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2019.115262
		CHEMBL4648289	178122	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	251	2	0	1	3.8	CN(C)[C@H]1CCc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2019.115262
		11525867	96226	1	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	479	7	1	3	6.2	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c(Cl)cc(Cl)cc21	10.1021/jm200547z
		CHEMBL260870	96226	1	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	479	7	1	3	6.2	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c(Cl)cc(Cl)cc21	10.1021/jm200547z
		66801160	112052	0	None	-1	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	468	7	1	6	3.6	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
		CHEMBL3289947	112052	0	None	-1	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	468	7	1	6	3.6	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
		1621	2429	17	None	-34	45	Rat	8.0	pKi	=	8.0	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm030826m
		17	2429	17	None	-34	45	Rat	8.0	pKi	=	8.0	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm030826m
		5761	2429	17	None	-34	45	Rat	8.0	pKi	=	8.0	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm030826m
		CHEMBL263881	2429	17	None	-34	45	Rat	8.0	pKi	=	8.0	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm030826m
		DB04829	2429	17	None	-34	45	Rat	8.0	pKi	=	8.0	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm030826m
		118753672	120618	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5-HT7 (unknown origin)Binding affinity to 5-HT7 (unknown origin)	ChEMBL	394	6	0	3	4.9	CN1C(=O)C2(CCCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1016/j.bmc.2013.06.020
		CHEMBL2413451	120618	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5-HT7 (unknown origin)Binding affinity to 5-HT7 (unknown origin)	ChEMBL	394	6	0	3	4.9	CN1C(=O)C2(CCCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1016/j.bmc.2013.06.020
		CHEMBL3546228	120618	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5-HT7 (unknown origin)Binding affinity to 5-HT7 (unknown origin)	ChEMBL	394	6	0	3	4.9	CN1C(=O)C2(CCCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1016/j.bmc.2013.06.020
		11740526	206087	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1021/acs.jmedchem.2c00633
		CHEMBL2311141	206087	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1021/acs.jmedchem.2c00633
		CHEMBL85602	206087	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1021/acs.jmedchem.2c00633
		11740526	206087	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1016/j.ejmech.2011.05.010
		CHEMBL2311141	206087	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1016/j.ejmech.2011.05.010
		CHEMBL85602	206087	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1016/j.ejmech.2011.05.010
		11740526	206087	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1016/s0960-894x(02)00485-7
		CHEMBL2311141	206087	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1016/s0960-894x(02)00485-7
		CHEMBL85602	206087	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1016/s0960-894x(02)00485-7
		162647173	179631	0	None	-2	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	438	7	1	6	3.3	Cn1ccc2c(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)cccc21	10.1016/j.ejmech.2020.112149
		CHEMBL4742856	179631	0	None	-2	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	438	7	1	6	3.3	Cn1ccc2c(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)cccc21	10.1016/j.ejmech.2020.112149
		11740526	206087	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1021/jm070279v
		CHEMBL2311141	206087	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1021/jm070279v
		CHEMBL85602	206087	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1021/jm070279v
		10064053	95907	0	None	-5	6	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	311	1	0	1	5.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2ccccc2)c1-3	10.1021/jm030030n
		CHEMBL25924	95907	0	None	-5	6	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	311	1	0	1	5.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2ccccc2)c1-3	10.1021/jm030030n
		10064053	95907	0	None	-5	6	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	311	1	0	1	5.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2ccccc2)c1-3	10.1021/jm0108505
		CHEMBL25924	95907	0	None	-5	6	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	311	1	0	1	5.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2ccccc2)c1-3	10.1021/jm0108505
		2470	3653	50	None	-389	59	Rat	8.0	pKi	=	8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
		3300	3653	50	None	-389	59	Rat	8.0	pKi	=	8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
		5265	3653	50	None	-389	59	Rat	8.0	pKi	=	8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
		99	3653	50	None	-389	59	Rat	8.0	pKi	=	8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
		CHEMBL267930	3653	50	None	-389	59	Rat	8.0	pKi	=	8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
		156016177	177654	0	None	18	7	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	307	0	1	4	3.6	CN1CCc2cccc3c2C1Cc1ccc2nc(N)sc2c1-3	10.1016/j.bmc.2020.115578
		CHEMBL4641502	177654	0	None	18	7	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	307	0	1	4	3.6	CN1CCc2cccc3c2C1Cc1ccc2nc(N)sc2c1-3	10.1016/j.bmc.2020.115578
		66801173	112063	0	None	-1	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	486	8	1	7	4.4	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
		CHEMBL3289958	112063	0	None	-1	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	486	8	1	7	4.4	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
		66801226	112077	0	None	9	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	452	7	1	6	3.1	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
		CHEMBL3289971	112077	0	None	9	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	452	7	1	6	3.1	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
		3994476	98976	9	None	-13	5	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	345	7	0	5	1.7	COc1ccccc1N1CCN(CCCCN2C(=O)CCC2=O)CC1	10.1016/j.ejmech.2021.113931
		CHEMBL279841	98976	9	None	-13	5	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	345	7	0	5	1.7	COc1ccccc1N1CCN(CCCCN2C(=O)CCC2=O)CC1	10.1016/j.ejmech.2021.113931
		57399091	68423	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	440	8	1	6	2.7	COc1ccccc1N1CCN(CCCNS(=O)(=O)c2cccc3cccnc23)CC1	10.1016/j.bmc.2011.09.044
		CHEMBL1917344	68423	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	440	8	1	6	2.7	COc1ccccc1N1CCN(CCCNS(=O)(=O)c2cccc3cccnc23)CC1	10.1016/j.bmc.2011.09.044
		11380477	179682	0	None	-17	4	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	280	2	1	4	2.7	CC(C)n1nc2c(c1-c1ccc(C#N)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
		CHEMBL4743582	179682	0	None	-17	4	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	280	2	1	4	2.7	CC(C)n1nc2c(c1-c1ccc(C#N)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
		11288612	182611	0	None	-29	4	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	267	2	1	3	3.0	c1ccc(-c2c3c(nn2C2CCC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
		CHEMBL4788327	182611	0	None	-29	4	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	267	2	1	3	3.0	c1ccc(-c2c3c(nn2C2CCC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
		44209480	70170	0	None	-81	11	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin)Displacement of [3H]-LSD from 5HT7 receptor (unknown origin)	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2020.115943
		CHEMBL1940418	70170	0	None	-81	11	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin)Displacement of [3H]-LSD from 5HT7 receptor (unknown origin)	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2020.115943
		56944862	156768	0	None	-19	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	477	8	2	3	5.3	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(Cl)cc1	10.1021/acs.jmedchem.7b00839
		CHEMBL4070715	156768	0	None	-19	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	477	8	2	3	5.3	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(Cl)cc1	10.1021/acs.jmedchem.7b00839
		44209480	70170	0	None	-81	11	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
		CHEMBL1940418	70170	0	None	-81	11	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
		44209480	70170	0	None	-81	11	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2011.12.019
		CHEMBL1940418	70170	0	None	-81	11	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2011.12.019
		145947560	167708	0	None	-4	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	344	6	0	3	4.2	Cc1cc(OCCCN2CCN(c3ccccc3)CC2)ccc1Cl	10.1016/j.bmcl.2018.04.059
		CHEMBL4212812	167708	0	None	-4	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	344	6	0	3	4.2	Cc1cc(OCCCN2CCN(c3ccccc3)CC2)ccc1Cl	10.1016/j.bmcl.2018.04.059
		CHEMBL4302457	167708	0	None	-4	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	344	6	0	3	4.2	Cc1cc(OCCCN2CCN(c3ccccc3)CC2)ccc1Cl	10.1016/j.bmcl.2018.04.059
		3994476	98976	9	None	-13	5	Rat	7.1	pKi	=	7.1	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	345	7	0	5	1.7	COc1ccccc1N1CCN(CCCCN2C(=O)CCC2=O)CC1	10.1016/j.bmcl.2004.09.029
		CHEMBL279841	98976	9	None	-13	5	Rat	7.1	pKi	=	7.1	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	345	7	0	5	1.7	COc1ccccc1N1CCN(CCCCN2C(=O)CCC2=O)CC1	10.1016/j.bmcl.2004.09.029
		90656671	110990	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	387	7	1	4	4.7	Oc1cccc(N(CCCN2CCN(c3ccccc3)CC2)c2ccccc2)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262423	110990	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	387	7	1	4	4.7	Oc1cccc(N(CCCN2CCN(c3ccccc3)CC2)c2ccccc2)c1	10.1016/j.ejmech.2014.04.034
		90644078	112089	0	None	-29	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	490	7	1	7	4.2	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
		CHEMBL3289983	112089	0	None	-29	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	490	7	1	7	4.2	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
		145963863	164227	0	None	2	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccc(Br)cc1	10.1021/acs.jmedchem.8b00828
		CHEMBL4211094	164227	0	None	2	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccc(Br)cc1	10.1021/acs.jmedchem.8b00828
		42618254	182016	0	None	-1	2	Human	6.0	pKi	=	6.0	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	412	5	0	5	3.9	Cc1ccccc1-n1c(=O)n(CCN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.bmcl.2009.02.008
		CHEMBL478073	182016	0	None	-1	2	Human	6.0	pKi	=	6.0	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	412	5	0	5	3.9	Cc1ccccc1-n1c(=O)n(CCN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.bmcl.2009.02.008
		127029375	138262	0	None	4	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	460	6	2	5	2.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(Cl)cc3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
		CHEMBL3770522	138262	0	None	4	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	460	6	2	5	2.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(Cl)cc3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
		134155461	154487	0	None	-1	6	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	291	4	1	2	3.6	c1ccc2c(c1)CCN(CCCc1nc3ccccc3[nH]1)C2	10.1016/j.bmc.2016.09.019
		CHEMBL3959209	154487	0	None	-1	6	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	291	4	1	2	3.6	c1ccc2c(c1)CCN(CCCc1nc3ccccc3[nH]1)C2	10.1016/j.bmc.2016.09.019
		CHEMBL3990475	154487	0	None	-1	6	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	291	4	1	2	3.6	c1ccc2c(c1)CCN(CCCc1nc3ccccc3[nH]1)C2	10.1016/j.bmc.2016.09.019
		66800965	158194	0	None	-50	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	461	8	2	3	4.8	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(F)c1	10.1021/acs.jmedchem.7b00839
		CHEMBL4087852	158194	0	None	-50	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	461	8	2	3	4.8	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(F)c1	10.1021/acs.jmedchem.7b00839
		134155461	154487	0	None	-1	6	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	291	4	1	2	3.6	c1ccc2c(c1)CCN(CCCc1nc3ccccc3[nH]1)C2	10.1016/j.bmc.2016.09.019
		CHEMBL3959209	154487	0	None	-1	6	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	291	4	1	2	3.6	c1ccc2c(c1)CCN(CCCc1nc3ccccc3[nH]1)C2	10.1016/j.bmc.2016.09.019
		CHEMBL3990475	154487	0	None	-1	6	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	291	4	1	2	3.6	c1ccc2c(c1)CCN(CCCc1nc3ccccc3[nH]1)C2	10.1016/j.bmc.2016.09.019
		156011357	177338	0	None	2	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	387	2	0	1	5.8	CN(C)[C@H]1CCc2c(cccc2-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1	10.1016/j.bmc.2019.115262
		CHEMBL4637353	177338	0	None	2	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	387	2	0	1	5.8	CN(C)[C@H]1CCc2c(cccc2-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1	10.1016/j.bmc.2019.115262
		44395797	66786	0	None	-2	2	Rat	6.0	pKi	=	6.0	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	393	6	0	5	2.7	COc1ccccc1N1CCN(Cc2ccccc2CN2C(=O)CCC2=O)CC1	10.1016/j.bmcl.2004.09.029
		CHEMBL185936	66786	0	None	-2	2	Rat	6.0	pKi	=	6.0	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	393	6	0	5	2.7	COc1ccccc1N1CCN(Cc2ccccc2CN2C(=O)CCC2=O)CC1	10.1016/j.bmcl.2004.09.029
		155566855	176242	0	None	-645	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	352	3	2	5	3.2	Cc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2ccccc2)c2ccccc12	10.1016/j.ejmech.2019.06.001
		CHEMBL4586353	176242	0	None	-645	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	352	3	2	5	3.2	Cc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2ccccc2)c2ccccc12	10.1016/j.ejmech.2019.06.001
		CHEMBL4594758	176242	0	None	-645	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	352	3	2	5	3.2	Cc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2ccccc2)c2ccccc12	10.1016/j.ejmech.2019.06.001
		52952307	62589	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	477	7	1	6	5.7	O=C(CCNC1CCN(c2ccc([N+](=O)[O-])cc2C(F)(F)F)CC1)c1csc2ccccc12	10.1021/jm2000773
		CHEMBL1782806	62589	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	477	7	1	6	5.7	O=C(CCNC1CCN(c2ccc([N+](=O)[O-])cc2C(F)(F)F)CC1)c1csc2ccccc12	10.1021/jm2000773
		52952200	62584	0	None	-	1	Human	4.0	pKi	=	4.0	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	413	6	0	6	4.3	O=C(CCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1)c1csc2ccc(F)cc12	10.1021/jm2000773
		CHEMBL1782798	62584	0	None	-	1	Human	4.0	pKi	=	4.0	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	413	6	0	6	4.3	O=C(CCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1)c1csc2ccc(F)cc12	10.1021/jm2000773
		118709750	113540	0	None	-83	9	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1cccc(F)c1	10.1016/j.bmcl.2014.07.018
		CHEMBL3321791	113540	0	None	-83	9	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1cccc(F)c1	10.1016/j.bmcl.2014.07.018
		76310813	106397	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	364	4	0	2	5.9	C1=C(c2ccccc2)CCN(Cc2cn(-c3ccccc3)c3ccccc23)C1	10.1016/j.ejmech.2014.01.055
		CHEMBL3121433	106397	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	364	4	0	2	5.9	C1=C(c2ccccc2)CCN(Cc2cn(-c3ccccc3)c3ccccc23)C1	10.1016/j.ejmech.2014.01.055
		CHEMBL3139442	106397	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	364	4	0	2	5.9	C1=C(c2ccccc2)CCN(Cc2cn(-c3ccccc3)c3ccccc23)C1	10.1016/j.ejmech.2014.01.055
		11454449	84724	0	None	2	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	407	7	1	4	3.8	COc1ccccc1N1CCN(CCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
		CHEMBL222807	84724	0	None	2	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	407	7	1	4	3.8	COc1ccccc1N1CCN(CCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
		44401042	124829	0	None	-24	9	Human	7.0	pKi	=	7.0	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.6	CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL364270	124829	0	None	-24	9	Human	7.0	pKi	=	7.0	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.6	CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
		90656670	110991	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	401	8	1	4	4.6	Oc1cccc(N(CCCN2CCN(c3ccccc3)CC2)Cc2ccccc2)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262424	110991	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	401	8	1	4	4.6	Oc1cccc(N(CCCN2CCN(c3ccccc3)CC2)Cc2ccccc2)c1	10.1016/j.ejmech.2014.04.034
		155554036	174201	0	None	-72	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	334	4	1	7	1.4	CN1CCN(c2nc(N)nc(COc3ccccc3Cl)n2)CC1	10.1016/j.ejmech.2019.06.022
		CHEMBL4548041	174201	0	None	-72	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	334	4	1	7	1.4	CN1CCN(c2nc(N)nc(COc3ccccc3Cl)n2)CC1	10.1016/j.ejmech.2019.06.022
		162671630	183760	0	None	-32	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	467	9	1	6	4.6	COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(=O)OC(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4791207	183760	0	None	-32	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	467	9	1	6	4.6	COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(=O)OC(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4803834	183760	0	None	-32	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	467	9	1	6	4.6	COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(=O)OC(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
		66801053	183436	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	470	8	2	7	3.1	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1c[nH]c2ncccc12	10.1016/j.ejmech.2020.112437
		CHEMBL4798767	183436	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	470	8	2	7	3.1	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1c[nH]c2ncccc12	10.1016/j.ejmech.2020.112437
		122181250	121854	0	None	-1	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	418	6	1	4	3.0	O=C1NC2(CCc3ccccc32)C(=O)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2015.04.026
		CHEMBL3589976	121854	0	None	-1	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	418	6	1	4	3.0	O=C1NC2(CCc3ccccc32)C(=O)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2015.04.026
		71460453	81362	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	488	8	1	4	5.2	O=S(=O)(NC1CCN(CCSc2ccccc2-c2ccccc2)CC1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159310	81362	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	488	8	1	4	5.2	O=S(=O)(NC1CCN(CCSc2ccccc2-c2ccccc2)CC1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2012.07.043
		60195994	81812	2	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	266	2	1	2	3.4	Cc1ccc(-c2cccc(N3CCNCC3)c2)cc1C	10.1021/jm3003679
		CHEMBL2164335	81812	2	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	266	2	1	2	3.4	Cc1ccc(-c2cccc(N3CCNCC3)c2)cc1C	10.1021/jm3003679
		145964390	164308	0	None	95	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	564	7	1	4	3.9	O=S(=O)(NC1CCN(CCOc2cc(Br)ccc2I)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
		CHEMBL4212254	164308	0	None	95	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	564	7	1	4	3.9	O=S(=O)(NC1CCN(CCOc2cc(Br)ccc2I)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
		162659287	181289	0	None	-85	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	459	7	1	6	4.2	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(F)cc2s1	10.1016/j.ejmech.2020.112149
		CHEMBL4762226	181289	0	None	-85	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	459	7	1	6	4.2	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(F)cc2s1	10.1016/j.ejmech.2020.112149
		53245590	92399	43	None	-2	4	Human	6.0	pKi	=	6.0	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	420	6	0	7	3.9	COc1cc2nc(C3CC3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC	10.1021/ml400176n
		CHEMBL2431120	92399	43	None	-2	4	Human	6.0	pKi	=	6.0	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	420	6	0	7	3.9	COc1cc2nc(C3CC3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC	10.1021/ml400176n
		145976946	163934	0	None	1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	416	7	1	4	3.8	CC(C)(C)c1cccc(OCCN2CCC(NS(=O)(=O)c3ccccc3)CC2)c1	10.1021/acs.jmedchem.8b00828
		CHEMBL4207568	163934	0	None	1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	416	7	1	4	3.8	CC(C)(C)c1cccc(OCCN2CCC(NS(=O)(=O)c3ccccc3)CC2)c1	10.1021/acs.jmedchem.8b00828
		155538350	172380	0	None	-20	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	466	9	1	8	2.0	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ncccn4)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
		CHEMBL4476370	172380	0	None	-20	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	466	9	1	8	2.0	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ncccn4)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
		164611003	185344	0	None	-87	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	382	4	1	7	2.7	CC(Oc1cc(Cl)cc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
		CHEMBL4860006	185344	0	None	-87	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	382	4	1	7	2.7	CC(Oc1cc(Cl)cc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
		56850796	71532	0	None	-7	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	371	8	1	4	2.6	O=C1C2CCCN2C(=O)N1CCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
		CHEMBL1926686	71532	0	None	-7	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	371	8	1	4	2.6	O=C1C2CCCN2C(=O)N1CCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
		CHEMBL1962913	71532	0	None	-7	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	371	8	1	4	2.6	O=C1C2CCCN2C(=O)N1CCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
		76332585	106401	0	None	3	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	381	4	0	3	5.3	Cc1ccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)cc1	10.1016/j.ejmech.2014.01.055
		CHEMBL3121441	106401	0	None	3	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	381	4	0	3	5.3	Cc1ccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)cc1	10.1016/j.ejmech.2014.01.055
		CHEMBL3139446	106401	0	None	3	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	381	4	0	3	5.3	Cc1ccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)cc1	10.1016/j.ejmech.2014.01.055
		11674602	68414	2	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	344	7	1	3	2.8	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2011.09.044
		CHEMBL1917335	68414	2	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	344	7	1	3	2.8	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2011.09.044
		145947627	167691	0	None	10	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	528	9	2	6	3.2	COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(C(c4ccccc4)c4ccccc4)CC3)C2=O)cc1	10.1016/j.ejmech.2018.01.093
		CHEMBL4163626	167691	0	None	10	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	528	9	2	6	3.2	COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(C(c4ccccc4)c4ccccc4)CC3)C2=O)cc1	10.1016/j.ejmech.2018.01.093
		CHEMBL4302240	167691	0	None	10	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	528	9	2	6	3.2	COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(C(c4ccccc4)c4ccccc4)CC3)C2=O)cc1	10.1016/j.ejmech.2018.01.093
		90644076	112081	0	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	406	7	1	7	2.4	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1cccs1	10.1021/jm401895u
		CHEMBL3289975	112081	0	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	406	7	1	7	2.4	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1cccs1	10.1021/jm401895u
		134131147	142231	0	None	-5	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	436	8	0	5	4.6	O=c1cc(-c2ccccc2)ncn1CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2016.12.039
		CHEMBL3884584	142231	0	None	-5	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	436	8	0	5	4.6	O=c1cc(-c2ccccc2)ncn1CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2016.12.039
		168282733	191059	0	None	-79	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	386	9	3	9	1.4	COc1ccccc1N1CCN(CCCCCNc2nc(N)nc(N)n2)CC1	10.1016/j.ejmech.2021.113931
		CHEMBL5187317	191059	0	None	-79	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	386	9	3	9	1.4	COc1ccccc1N1CCN(CCCCCNc2nc(N)nc(N)n2)CC1	10.1016/j.ejmech.2021.113931
		164628531	186464	0	None	-131	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	5	1	7	3.0	CCC(Oc1cc(Cl)cc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
		CHEMBL4876727	186464	0	None	-131	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	5	1	7	3.0	CCC(Oc1cc(Cl)cc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
		122483229	138102	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.5	O=C(CCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3764477	138102	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.5	O=C(CCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765850	138102	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.5	O=C(CCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		90654684	110105	0	None	-6	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	502	8	1	4	4.1	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.ejmech.2014.03.005
		CHEMBL3235756	110105	0	None	-6	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	502	8	1	4	4.1	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.ejmech.2014.03.005
		90654831	109826	0	None	-17	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	512	9	0	5	4.4	CCOc1ccccc1N1CCN(CCCN2C(=O)N(C)C(=O)C2(c2ccccc2)c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
		CHEMBL3233401	109826	0	None	-17	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	512	9	0	5	4.4	CCOc1ccccc1N1CCN(CCCN2C(=O)N(C)C(=O)C2(c2ccccc2)c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
		137635884	155900	0	None	-5	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	427	7	2	3	4.1	Cc1cccc(S(=O)(=O)NCCCN2CC=C(c3c[nH]c4ccc(F)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
		CHEMBL4060649	155900	0	None	-5	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	427	7	2	3	4.1	Cc1cccc(S(=O)(=O)NCCCN2CC=C(c3c[nH]c4ccc(F)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
		CHEMBL5087742	215116	0	None	-22	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		C[C@H]1C[C@H](NS(=O)(=O)c2csc3ccccc23)CN1CCCc1noc2cc(F)ccc12	10.1021/acs.jmedchem.1c00497
		90656702	112609	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	435	9	1	4	5.2	CN(CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3262433	112609	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	435	9	1	4	5.2	CN(CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		CHEMBL3302235	112609	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	435	9	1	4	5.2	CN(CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
		4713248	207907	3	None	2	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	281	5	2	3	1.2	CNS(=O)(=O)c1ccc2[nH]cc(CCN(C)C)c2c1	10.1021/jm030030n
		CHEMBL96729	207907	3	None	2	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	281	5	2	3	1.2	CNS(=O)(=O)c1ccc2[nH]cc(CCN(C)C)c2c1	10.1021/jm030030n
		155531846	171645	0	None	-18	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	300	4	1	7	0.8	CN1CCN(c2nc(N)nc(COc3ccccc3)n2)CC1	10.1016/j.ejmech.2019.06.022
		CHEMBL4465929	171645	0	None	-18	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	300	4	1	7	0.8	CN1CCN(c2nc(N)nc(COc3ccccc3)n2)CC1	10.1016/j.ejmech.2019.06.022
		162676589	183790	0	None	-6	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	395	8	1	4	4.4	COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4800511	183790	0	None	-6	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	395	8	1	4	4.4	COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
		CHEMBL4804122	183790	0	None	-6	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	395	8	1	4	4.4	COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
		164613772	188490	0	None	-2	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	380	6	1	5	2.9	O=C1CCc2cc(OCCCN3CCCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
		CHEMBL4859722	188490	0	None	-2	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	380	6	1	5	2.9	O=C1CCc2cc(OCCCN3CCCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
		CHEMBL5028215	188490	0	None	-2	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	380	6	1	5	2.9	O=C1CCc2cc(OCCCN3CCCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
		122483229	138102	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.5	O=C(CCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3764477	138102	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.5	O=C(CCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765850	138102	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.5	O=C(CCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		45028192	62587	1	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	416	5	0	6	4.6	O=C(CCN1CCCN(c2cnc3ccccc3n2)CC1)c1csc2ccccc12	10.1021/jm2000773
		CHEMBL1782801	62587	1	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	416	5	0	6	4.6	O=C(CCN1CCCN(c2cnc3ccccc3n2)CC1)c1csc2ccccc12	10.1021/jm2000773
		7125890	117938	12	None	-6	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	408	4	1	4	5.8	Cc1ccc(Nc2c(S(=O)(=O)c3ccccc3)cnc3ccc(Cl)cc23)cc1	10.1016/j.bmcl.2015.03.049
		CHEMBL3403341	117938	12	None	-6	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	408	4	1	4	5.8	Cc1ccc(Nc2c(S(=O)(=O)c3ccccc3)cnc3ccc(Cl)cc23)cc1	10.1016/j.bmcl.2015.03.049
		164613772	188490	0	None	-2	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	380	6	1	5	2.9	O=C1CCc2cc(OCCCN3CCCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
		CHEMBL4859722	188490	0	None	-2	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	380	6	1	5	2.9	O=C1CCc2cc(OCCCN3CCCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
		CHEMBL5028215	188490	0	None	-2	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	380	6	1	5	2.9	O=C1CCc2cc(OCCCN3CCCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
		155562652	175161	0	None	-15	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	552	9	1	7	5.3	COc1ccc(-c2c(=O)n(CCCCN3CCCC(c4c[nH]c5ccc(OC)cc45)C3)c(=O)n3ccccc23)cc1	10.1016/j.ejmech.2019.01.031
		CHEMBL4570209	175161	0	None	-15	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	552	9	1	7	5.3	COc1ccc(-c2c(=O)n(CCCCN3CCCC(c4c[nH]c5ccc(OC)cc45)C3)c(=O)n3ccccc23)cc1	10.1016/j.ejmech.2019.01.031
		60196076	81818	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	298	4	1	4	2.8	COc1cccc(OC)c1-c1ccccc1N1CCNCC1	10.1021/jm3003679
		CHEMBL2164342	81818	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	298	4	1	4	2.8	COc1cccc(OC)c1-c1ccccc1N1CCNCC1	10.1021/jm3003679
		44408805	76738	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	335	6	0	3	3.8	O=S(=O)(CCCCN1CCC2CCCCC2C1)c1ccccc1	10.1016/j.bmcl.2005.11.067
		CHEMBL206667	76738	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	335	6	0	3	3.8	O=S(=O)(CCCCN1CCC2CCCCC2C1)c1ccccc1	10.1016/j.bmcl.2005.11.067
		54758203	65994	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	497	7	1	3	6.4	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c1cc(Cl)c(F)c2Cl	10.1021/jm200547z
		CHEMBL1836783	65994	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	497	7	1	3	6.4	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c1cc(Cl)c(F)c2Cl	10.1021/jm200547z
		118626140	165918	0	None	-7	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	1	4	5.7	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1	10.1016/j.ejmech.2018.01.002
		CHEMBL4250244	165918	0	None	-7	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	1	4	5.7	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1	10.1016/j.ejmech.2018.01.002
		71456779	81410	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	450	7	1	4	3.7	O=S(=O)(NC1CCN(CCOc2cc(Cl)ccc2Cl)C1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2012.07.043
		CHEMBL2159454	81410	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	450	7	1	4	3.7	O=S(=O)(NC1CCN(CCOc2cc(Cl)ccc2Cl)C1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2012.07.043
		156017999	177819	0	None	6	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	302	2	0	2	4.3	CN(C)C1CCc2c(cccc2-c2cncc3ccccc23)C1	10.1016/j.bmc.2019.115262
		CHEMBL4643725	177819	0	None	6	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	302	2	0	2	4.3	CN(C)C1CCc2c(cccc2-c2cncc3ccccc23)C1	10.1016/j.bmc.2019.115262
		164628882	186450	0	None	-48	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	477	6	0	6	3.4	COc1ccccc1N1CCN(Cc2ccc(CN3C(=O)c4ccccc4S3(=O)=O)cc2)CC1	10.1016/j.bmcl.2021.128028
		CHEMBL4876545	186450	0	None	-48	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	477	6	0	6	3.4	COc1ccccc1N1CCN(Cc2ccc(CN3C(=O)c4ccccc4S3(=O)=O)cc2)CC1	10.1016/j.bmcl.2021.128028
		56649650	67858	0	None	-112	8	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	466	8	0	5	4.2	COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)C3)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
		CHEMBL1910141	67858	0	None	-112	8	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	466	8	0	5	4.2	COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)C3)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
		13091359	113539	0	None	-138	10	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
		CHEMBL3321790	113539	0	None	-138	10	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
		44455973	97468	7	None	-1	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	209	1	2	3	2.3	CCC1NC(N)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.080
		CHEMBL270176	97468	7	None	-1	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	209	1	2	3	2.3	CCC1NC(N)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.080
		10960943	204260	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	428	7	1	3	5.4	CC(=O)c1ccc2c3c1CCCC3(CCCCN1CC=C(c3ccccc3)CC1)C(=O)N2	10.1021/jm0104264
		CHEMBL71165	204260	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	428	7	1	3	5.4	CC(=O)c1ccc2c3c1CCCC3(CCCCN1CC=C(c3ccccc3)CC1)C(=O)N2	10.1021/jm0104264
		11488153	85140	0	None	2	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	430	8	1	4	4.4	N#Cc1cccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)c1	10.1021/jm049702f
		CHEMBL224935	85140	0	None	2	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	430	8	1	4	4.4	N#Cc1cccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)c1	10.1021/jm049702f
		198967	91774	57	None	-	1	Human	4.0	pKi	=	4.0	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	248	1	2	1	3.4	c1ccc(C2NCCc3c2[nH]c2ccccc32)cc1	10.1016/j.bmcl.2007.01.093
		CHEMBL241083	91774	57	None	-	1	Human	4.0	pKi	=	4.0	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	248	1	2	1	3.4	c1ccc(C2NCCc3c2[nH]c2ccccc32)cc1	10.1016/j.bmcl.2007.01.093
		CHEMBL5285633	194305	0	None	-2	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis	ChEMBL	450	7	0	5	4.2	O=C1CC2CCCc3ccsc3C2=NN1CCCCN1CCN(Cc2ccccc2)CC1	10.1016/j.bmc.2023.117256
		44424655	143290	0	None	-1	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	440	8	0	9	1.4	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2007.05.017
		CHEMBL389700	143290	0	None	-1	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	440	8	0	9	1.4	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2007.05.017
		60167309	75297	0	None	-6	7	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	400	6	1	4	5.3	OC1(c2ccc(Cl)cc2)CCN(CCCCc2nc3ccccc3s2)CC1	10.1016/j.ejmech.2012.03.042
		CHEMBL2037432	75297	0	None	-6	7	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	400	6	1	4	5.3	OC1(c2ccc(Cl)cc2)CCN(CCCCc2nc3ccccc3s2)CC1	10.1016/j.ejmech.2012.03.042
		60167309	75297	0	None	-6	7	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	400	6	1	4	5.3	OC1(c2ccc(Cl)cc2)CCN(CCCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
		CHEMBL2037432	75297	0	None	-6	7	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	400	6	1	4	5.3	OC1(c2ccc(Cl)cc2)CCN(CCCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
		168295839	192245	0	None	-12	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	370	9	3	8	1.8	Nc1nc(N)nc(NCCCCCCN2CCN(c3ccccc3)CC2)n1	10.1016/j.ejmech.2021.113931
		CHEMBL5205324	192245	0	None	-12	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	370	9	3	8	1.8	Nc1nc(N)nc(NCCCCCCN2CCN(c3ccccc3)CC2)n1	10.1016/j.ejmech.2021.113931
		156010295	177135	0	None	-3	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	306	3	0	2	4.3	CCCN1CCc2cccc3c2C1Cc1ccc(N(C)C)cc1-3	10.1016/j.bmc.2020.115578
		CHEMBL4633889	177135	0	None	-3	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	306	3	0	2	4.3	CCCN1CCc2cccc3c2C1Cc1ccc(N(C)C)cc1-3	10.1016/j.bmc.2020.115578
		155515324	169955	0	None	-27	4	Human	4.0	pKi	=	4.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	382	4	1	8	0.8	CN1CCN(c2nc(N)nc(CS(=O)(=O)c3ccccc3Cl)n2)CC1	10.1016/j.ejmech.2019.06.022
		CHEMBL4441655	169955	0	None	-27	4	Human	4.0	pKi	=	4.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	382	4	1	8	0.8	CN1CCN(c2nc(N)nc(CS(=O)(=O)c3ccccc3Cl)n2)CC1	10.1016/j.ejmech.2019.06.022
		155519393	170419	0	None	-97	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	397	7	2	4	5.3	COc1ccc2[nH]cc(CCNCc3ccc(-c4cnc5ccccc5c4)o3)c2c1	10.1016/j.ejmech.2019.111857
		CHEMBL4448285	170419	0	None	-97	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	397	7	2	4	5.3	COc1ccc2[nH]cc(CCNCc3ccc(-c4cnc5ccccc5c4)o3)c2c1	10.1016/j.ejmech.2019.111857
		156019370	177957	0	None	-25	5	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	422	9	1	5	4.4	O=C(NCCCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccccc1	10.1016/j.bmc.2020.115459
		CHEMBL4645793	177957	0	None	-25	5	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	422	9	1	5	4.4	O=C(NCCCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccccc1	10.1016/j.bmc.2020.115459
		134131159	142247	0	None	1	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	416	10	0	5	4.5	c1ccc(CN2CCN(CCCCCOc3cc(-c4ccccc4)ncn3)CC2)cc1	10.1016/j.bmc.2016.12.039
		CHEMBL3884743	142247	0	None	1	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	416	10	0	5	4.5	c1ccc(CN2CCN(CCCCCOc3cc(-c4ccccc4)ncn3)CC2)cc1	10.1016/j.bmc.2016.12.039
		57397411	68430	0	None	1	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	401	7	1	4	3.8	O=S(=O)(NCCCCN1CCC2CCCCC2C1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.09.044
		CHEMBL1917351	68430	0	None	1	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	401	7	1	4	3.8	O=S(=O)(NCCCCN1CCC2CCCCC2C1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.09.044
		CHEMBL5265814	193454	0	None	-1	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis	ChEMBL	436	7	0	5	3.8	O=C1CC2CCc3ccsc3C2=NN1CCCCN1CCN(Cc2ccccc2)CC1	10.1016/j.bmc.2023.117256
		1621	2429	17	None	-22	45	Human	8.1	pKd	=	8.1	Binding	GRAC: human 5-HT7 radioligandGRAC: human 5-HT7 radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		17	2429	17	None	-22	45	Human	8.1	pKd	=	8.1	Binding	GRAC: human 5-HT7 radioligandGRAC: human 5-HT7 radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		5761	2429	17	None	-22	45	Human	8.1	pKd	=	8.1	Binding	GRAC: human 5-HT7 radioligandGRAC: human 5-HT7 radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL263881	2429	17	None	-22	45	Human	8.1	pKd	=	8.1	Binding	GRAC: human 5-HT7 radioligandGRAC: human 5-HT7 radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB04829	2429	17	None	-22	45	Human	8.1	pKd	=	8.1	Binding	GRAC: human 5-HT7 radioligandGRAC: human 5-HT7 radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		3233	3512	44	None	2	12	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10807680
		3247	3512	44	None	2	12	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10807680
		6604889	3512	44	None	2	12	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10807680
		CHEMBL282199	3512	44	None	2	12	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10807680
		DB13988	3512	44	None	2	12	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10807680
		284	2915	69	None	-	1	Human	8.6	pKd	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	15	1	1	5.5	CCCCCCCC/C=C\CCCCCCCC(=O)N	10571256
		5283387	2915	69	None	-	1	Human	8.6	pKd	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	15	1	1	5.5	CCCCCCCC/C=C\CCCCCCCC(=O)N	10571256
		CHEMBL15927	2915	69	None	-	1	Human	8.6	pKd	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	15	1	1	5.5	CCCCCCCC/C=C\CCCCCCCC(=O)N	10571256
		2389	3331	118	None	-7	67	Rat	9.0	pKd	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	7908055
		2389	3331	118	None	-7	67	Rat	9.0	pKd	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	8997630
		5073	3331	118	None	-7	67	Rat	9.0	pKd	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	7908055
		5073	3331	118	None	-7	67	Rat	9.0	pKd	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	8997630
		96	3331	118	None	-7	67	Rat	9.0	pKd	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	7908055
		96	3331	118	None	-7	67	Rat	9.0	pKd	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	8997630
		CHEMBL85	3331	118	None	-7	67	Rat	9.0	pKd	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	7908055
		CHEMBL85	3331	118	None	-7	67	Rat	9.0	pKd	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	8997630
		DB00734	3331	118	None	-7	67	Rat	9.0	pKd	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	7908055
		DB00734	3331	118	None	-7	67	Rat	9.0	pKd	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	8997630
		1809	134	32	3H-MESULERGINE	-2	36	Rat	11.4	pKi	=	11.4	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	134	32	3H-MESULERGINE	-2	36	Rat	11.4	pKi	=	11.4	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	134	32	3H-MESULERGINE	-2	36	Rat	11.4	pKi	=	11.4	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		1809	134	32	3H-MESULERGINE	2	36	Guinea pig	12.1	pKi	=	12.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	134	32	3H-MESULERGINE	2	36	Guinea pig	12.1	pKi	=	12.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	134	32	3H-MESULERGINE	2	36	Guinea pig	12.1	pKi	=	12.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		5	139	72	3H-MESULERGINE	3	54	Guinea pig	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-MESULERGINE	3	54	Guinea pig	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-MESULERGINE	3	54	Guinea pig	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-MESULERGINE	3	54	Guinea pig	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		1809	134	32	3H-5HT	-7	36	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		1809	134	32	3H-5HT	-2	36	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		1809	134	32	UNDEFINED	-2	36	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	134	32	3H-5HT	-7	36	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	134	32	3H-5HT	-2	36	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	134	32	UNDEFINED	-2	36	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	134	32	3H-5HT	-7	36	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	134	32	3H-5HT	-2	36	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	134	32	UNDEFINED	-2	36	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		23643664	2350	8	UNDEFINED	-1	5	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	None
		8434	2350	8	UNDEFINED	-1	5	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	None
		CHEMBL243954	2350	8	UNDEFINED	-1	5	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	None
		5	139	72	3H-MESULERGINE	-5	54	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-MESULERGINE	-5	54	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-MESULERGINE	-5	54	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-MESULERGINE	-5	54	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		1809	134	32	3H-5HT	-2	36	Rat	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	134	32	3H-5HT	-2	36	Rat	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	134	32	3H-5HT	-2	36	Rat	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		1809	134	32	3H-5HT	-2	36	Rat	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	134	32	3H-5HT	-2	36	Rat	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	134	32	3H-5HT	-2	36	Rat	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		1809	134	32	3H-5CT	2	36	Guinea pig	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	134	32	3H-5CT	2	36	Guinea pig	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	134	32	3H-5CT	2	36	Guinea pig	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		5	139	72	3H-5CT	3	54	Guinea pig	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-5CT	3	54	Guinea pig	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-5CT	3	54	Guinea pig	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-5CT	3	54	Guinea pig	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		107	141	121	3H-MESULERGINE	1	30	Guinea pig	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	141	121	3H-MESULERGINE	1	30	Guinea pig	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	141	121	3H-MESULERGINE	1	30	Guinea pig	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1809	134	32	125I-LSD	-2	36	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	134	32	125I-LSD	-2	36	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	134	32	125I-LSD	-2	36	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4106	2502	22	3H-5HT	-2	34	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		5358812	2502	22	3H-5HT	-2	34	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		89	2502	22	3H-5HT	-2	34	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		CHEMBL93240	2502	22	3H-5HT	-2	34	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		1238	203174	24	3H-LSD	1	16	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
		CHEMBL64249	203174	24	3H-LSD	1	16	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
		1809	134	32	3H-5HT	2	36	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	134	32	3H-5HT	2	36	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	134	32	3H-5HT	2	36	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		1621	2429	17	3H-MESULERGINE	-1	45	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		17	2429	17	3H-MESULERGINE	-1	45	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		5761	2429	17	3H-MESULERGINE	-1	45	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL263881	2429	17	3H-MESULERGINE	-1	45	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB04829	2429	17	3H-MESULERGINE	-1	45	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		2389	3331	118	3H-MESULERGINE	-1	67	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		2389	3331	118	3H-5-CT	-8	67	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-MESULERGINE	-1	67	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-5-CT	-8	67	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-MESULERGINE	-1	67	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-5-CT	-8	67	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-MESULERGINE	-1	67	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-5-CT	-8	67	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-MESULERGINE	-1	67	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-5-CT	-8	67	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		1809	134	32	125I-LSD	-2	36	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	134	32	125I-LSD	-2	36	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	134	32	125I-LSD	-2	36	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		1809	134	32	UNDEFINED	-2	36	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	134	32	UNDEFINED	-2	36	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	134	32	UNDEFINED	-2	36	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		16362	3125	71	3H-LSD	-11	30	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		16362	3125	71	3H-LSD	-5	30	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		2172	3125	71	3H-LSD	-11	30	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		2172	3125	71	3H-LSD	-5	30	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		90	3125	71	3H-LSD	-11	30	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		90	3125	71	3H-LSD	-5	30	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		CHEMBL1423	3125	71	3H-LSD	-11	30	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		CHEMBL1423	3125	71	3H-LSD	-5	30	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		DB01100	3125	71	3H-LSD	-11	30	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		DB01100	3125	71	3H-LSD	-5	30	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		107	141	121	3H-5CT	1	30	Guinea pig	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	141	121	3H-5CT	1	30	Guinea pig	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	141	121	3H-5CT	1	30	Guinea pig	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1588	2325	27	125I-LSD	-6	44	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		28864	2325	27	125I-LSD	-6	44	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		43	2325	27	125I-LSD	-6	44	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL157138	2325	27	125I-LSD	-6	44	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB00589	2325	27	125I-LSD	-6	44	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		107	141	121	3H-5HT	-1	30	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	141	121	3H-5HT	-1	30	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	141	121	3H-5HT	-1	30	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		25107716	2351	43	UNDEFINED	3	7	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	None
		8436	2351	43	UNDEFINED	3	7	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	None
		CHEMBL522691	2351	43	UNDEFINED	3	7	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	None
		5	139	72	3H-5HT	-3	54	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5	139	72	3H-5HT	-5	54	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5	139	72	UNDEFINED	-5	54	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-5HT	-3	54	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-5HT	-5	54	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	UNDEFINED	-5	54	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-5HT	-3	54	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-5HT	-5	54	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	UNDEFINED	-5	54	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-5HT	-3	54	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-5HT	-5	54	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	UNDEFINED	-5	54	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		107	141	121	3H-MESULERGINE	-1	30	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	141	121	3H-MESULERGINE	-1	30	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	141	121	3H-MESULERGINE	-1	30	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		101	3822	24	3H-LSD	-2	14	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	440	6	0	6	3.9	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2	None
		55752	3822	24	3H-LSD	-2	14	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	440	6	0	6	3.9	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL35057	3822	24	3H-LSD	-2	14	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	440	6	0	6	3.9	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2	None
		4106	2502	22	125I-LSD	-2	34	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		5358812	2502	22	125I-LSD	-2	34	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		89	2502	22	125I-LSD	-2	34	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		CHEMBL93240	2502	22	125I-LSD	-2	34	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		46780481	107531	20	3H-5HT	-4	53	Mouse	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		9903970	107531	20	3H-5HT	-4	53	Mouse	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3187365	107531	20	3H-5HT	-4	53	Mouse	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3544974	107531	20	3H-5HT	-4	53	Mouse	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		1809	134	32	3H-5CT	-7	36	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	134	32	3H-5CT	-7	36	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	134	32	3H-5CT	-7	36	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		25107518	187284	0	UNDEFINED	20	4	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	441	10	1	3	5.4	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccccc1	None
		CHEMBL492871	187284	0	UNDEFINED	20	4	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	441	10	1	3	5.4	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccccc1	None
		1809	134	32	125I-LSD	-2	36	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	134	32	125I-LSD	-2	36	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	134	32	125I-LSD	-2	36	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		1588	2325	27	3H-5HT	-6	44	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		28864	2325	27	3H-5HT	-6	44	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		43	2325	27	3H-5HT	-6	44	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL157138	2325	27	3H-5HT	-6	44	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB00589	2325	27	3H-5HT	-6	44	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		1809	134	32	3H-5HT	-7	36	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	134	32	3H-5HT	-7	36	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	134	32	3H-5HT	-7	36	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		23643870	92864	0	UNDEFINED	35	3	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	448	9	1	4	4.6	CN(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
		CHEMBL243955	92864	0	UNDEFINED	35	3	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	448	9	1	4	4.6	CN(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
		46780481	107531	20	3H-LSD	-16	53	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		9903970	107531	20	3H-LSD	-16	53	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3187365	107531	20	3H-LSD	-16	53	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3544974	107531	20	3H-LSD	-16	53	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		1809	134	32	3H-5HT	-7	36	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	134	32	3H-5HT	-7	36	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	134	32	3H-5HT	-7	36	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		107	141	121	UNDEFINED	-1	30	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	141	121	UNDEFINED	-1	30	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	141	121	UNDEFINED	-1	30	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		2389	3331	118	3H-LSD	-7	67	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-LSD	-7	67	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-LSD	-7	67	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-LSD	-7	67	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-LSD	-7	67	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		107	141	121	3H-5HT	-3	30	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		107	141	121	3H-5HT	-1	30	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	141	121	3H-5HT	-3	30	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	141	121	3H-5HT	-1	30	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	141	121	3H-5HT	-3	30	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	141	121	3H-5HT	-1	30	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1809	134	32	3H-5CT	2	36	Guinea pig	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	134	32	3H-5CT	2	36	Guinea pig	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	134	32	3H-5CT	2	36	Guinea pig	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		25107520	187593	0	UNDEFINED	70	3	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	442	10	1	4	4.7	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1	None
		CHEMBL494709	187593	0	UNDEFINED	70	3	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	442	10	1	4	4.7	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1	None
		1809	134	32	3H-5HT	-12	36	Mouse	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	134	32	3H-5HT	-12	36	Mouse	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	134	32	3H-5HT	-12	36	Mouse	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		5	139	72	3H-5HT	3	54	Guinea pig	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-5HT	3	54	Guinea pig	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-5HT	3	54	Guinea pig	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-5HT	3	54	Guinea pig	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		107	141	121	3H-5HT	1	30	Guinea pig	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	141	121	3H-5HT	1	30	Guinea pig	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	141	121	3H-5HT	1	30	Guinea pig	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		4106	2502	22	3H-LSD	-2	34	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		5358812	2502	22	3H-LSD	-2	34	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		89	2502	22	3H-LSD	-2	34	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		CHEMBL93240	2502	22	3H-LSD	-2	34	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		2105	3054	37	3H-5HT	-5	33	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		47811	3054	37	3H-5HT	-5	33	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		48	3054	37	3H-5HT	-5	33	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		CHEMBL531	3054	37	3H-5HT	-5	33	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		DB01186	3054	37	3H-5HT	-5	33	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		2105	3054	37	3H-5HT	-5	33	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		47811	3054	37	3H-5HT	-5	33	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		48	3054	37	3H-5HT	-5	33	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		CHEMBL531	3054	37	3H-5HT	-5	33	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		DB01186	3054	37	3H-5HT	-5	33	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		4106	2502	22	125I-LSD	-2	34	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		5358812	2502	22	125I-LSD	-2	34	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		89	2502	22	125I-LSD	-2	34	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		CHEMBL93240	2502	22	125I-LSD	-2	34	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		4106	2502	22	125I-LSD	-2	34	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		5358812	2502	22	125I-LSD	-2	34	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		89	2502	22	125I-LSD	-2	34	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		CHEMBL93240	2502	22	125I-LSD	-2	34	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		23643663	92844	0	UNDEFINED	13	3	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	447	9	1	3	5.7	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
		CHEMBL243744	92844	0	UNDEFINED	13	3	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	447	9	1	3	5.7	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
		1809	134	32	3H-5HT	-2	36	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	134	32	3H-5HT	-2	36	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	134	32	3H-5HT	-2	36	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		1809	134	32	3H-5HT	-12	36	Mouse	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	134	32	3H-5HT	-12	36	Mouse	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	134	32	3H-5HT	-12	36	Mouse	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		115237	55585	119	3H-5HT	-5	54	Mouse	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	55585	119	3H-5HT	-5	54	Mouse	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		1238	203174	24	3H-LSD	1	16	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
		CHEMBL64249	203174	24	3H-LSD	1	16	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
		5	139	72	3H-5CT	3	54	Guinea pig	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-5CT	3	54	Guinea pig	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-5CT	3	54	Guinea pig	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-5CT	3	54	Guinea pig	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		2389	3331	118	3H-LSD	-7	67	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-LSD	-7	67	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-LSD	-7	67	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-LSD	-7	67	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-LSD	-7	67	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		2389	3331	118	3H-LSD	-7	67	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-LSD	-7	67	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-LSD	-7	67	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-LSD	-7	67	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-LSD	-7	67	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5	139	72	3H-5HT	-5	54	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-5HT	-5	54	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-5HT	-5	54	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-5HT	-5	54	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5	139	72	3H-5HT	-5	54	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-5HT	-5	54	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-5HT	-5	54	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-5HT	-5	54	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		107	141	121	3H-5CT	1	30	Guinea pig	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	141	121	3H-5CT	1	30	Guinea pig	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	141	121	3H-5CT	1	30	Guinea pig	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		133	2496	52	3H-MESULERGINE	-15	42	Guinea pig	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	2496	52	3H-MESULERGINE	-15	42	Guinea pig	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	2496	52	3H-MESULERGINE	-15	42	Guinea pig	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	2496	52	3H-MESULERGINE	-15	42	Guinea pig	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	2496	52	3H-MESULERGINE	-15	42	Guinea pig	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		2389	3331	118	3H-5HT	-4	67	Mouse	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-5HT	-4	67	Mouse	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-5HT	-4	67	Mouse	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-5HT	-4	67	Mouse	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-5HT	-4	67	Mouse	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		4106	2502	22	3H-LSD	-4	34	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		5358812	2502	22	3H-LSD	-4	34	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		89	2502	22	3H-LSD	-4	34	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		CHEMBL93240	2502	22	3H-LSD	-4	34	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		107	141	121	125I-LSD	-1	30	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	141	121	125I-LSD	-1	30	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	141	121	125I-LSD	-1	30	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		107	141	121	125I-LSD	-1	30	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	141	121	125I-LSD	-1	30	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	141	121	125I-LSD	-1	30	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		103	4153	61	3H-LSD	-2	53	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	4153	61	3H-LSD	-2	53	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	4153	61	3H-LSD	-2	53	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	4153	61	3H-LSD	-2	53	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	4153	61	3H-LSD	-2	53	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5	139	72	125I-LSD	-5	54	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	125I-LSD	-5	54	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	125I-LSD	-5	54	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	125I-LSD	-5	54	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5	139	72	125I-LSD	-5	54	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	125I-LSD	-5	54	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	125I-LSD	-5	54	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	125I-LSD	-5	54	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		242	470	124	3H-LSD	-15	51	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	470	124	3H-LSD	-15	51	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	470	124	3H-LSD	-15	51	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	470	124	3H-LSD	-15	51	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	470	124	3H-LSD	-15	51	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		206	2493	16	3H-MESULERGINE	-6	25	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		68848	2493	16	3H-MESULERGINE	-6	25	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		CHEMBL12314	2493	16	3H-MESULERGINE	-6	25	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		133	2496	52	3H-MESULERGINE	-16	42	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	2496	52	3H-MESULERGINE	-16	42	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	2496	52	3H-MESULERGINE	-16	42	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	2496	52	3H-MESULERGINE	-16	42	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	2496	52	3H-MESULERGINE	-16	42	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		4106	2502	22	3H-5HT	-30	34	Guinea pig	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		5358812	2502	22	3H-5HT	-30	34	Guinea pig	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		89	2502	22	3H-5HT	-30	34	Guinea pig	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		CHEMBL93240	2502	22	3H-5HT	-30	34	Guinea pig	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		2470	3653	50	3H-5HT	-389	59	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		2470	3653	50	3H-LSD	-389	59	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-5HT	-389	59	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-LSD	-389	59	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-5HT	-389	59	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-LSD	-389	59	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-5HT	-389	59	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-LSD	-389	59	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-5HT	-389	59	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-LSD	-389	59	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		103	4153	61	3H-5HT	-8	53	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	4153	61	3H-5HT	-8	53	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	4153	61	3H-5HT	-8	53	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	4153	61	3H-5HT	-8	53	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	4153	61	3H-5HT	-8	53	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		242	470	124	3H-LSD	-15	51	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		242	470	124	[3H]-LSD	-15	51	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	470	124	3H-LSD	-15	51	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	470	124	[3H]-LSD	-15	51	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	470	124	3H-LSD	-15	51	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	470	124	[3H]-LSD	-15	51	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	470	124	3H-LSD	-15	51	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	470	124	[3H]-LSD	-15	51	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	470	124	3H-LSD	-15	51	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	470	124	[3H]-LSD	-15	51	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		31101	729	40	125I-LSD	-25	36	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		35	729	40	125I-LSD	-25	36	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		403	729	40	125I-LSD	-25	36	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		CHEMBL493	729	40	125I-LSD	-25	36	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		DB01200	729	40	125I-LSD	-25	36	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		31101	729	40	125I-LSD	-25	36	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		35	729	40	125I-LSD	-25	36	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		403	729	40	125I-LSD	-25	36	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		CHEMBL493	729	40	125I-LSD	-25	36	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		DB01200	729	40	125I-LSD	-25	36	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		None	216052	0	3H-5CT	-67	8	Guinea pig	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	339	4	3	3	1.9	CCC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C	None
		135	2532	43	3H-5HT	-21	58	Mouse	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		135	2532	43	3H-LSD	-50	58	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-5HT	-21	58	Mouse	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-LSD	-50	58	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-5HT	-21	58	Mouse	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-LSD	-50	58	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-5HT	-21	58	Mouse	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-LSD	-50	58	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-5HT	-21	58	Mouse	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-LSD	-50	58	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		135398745	2914	112	3H-LSD	-34	65	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-LSD	-34	65	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-LSD	-34	65	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-LSD	-34	65	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		2470	3653	50	3H-5HT	-3019	59	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-5HT	-3019	59	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-5HT	-3019	59	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-5HT	-3019	59	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-5HT	-3019	59	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		2543	3707	68	3H-MESULERGINE	-44	32	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		5358	3707	68	3H-MESULERGINE	-44	32	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		54	3707	68	3H-MESULERGINE	-44	32	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL128	3707	68	3H-MESULERGINE	-44	32	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB00669	3707	68	3H-MESULERGINE	-44	32	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		100	3805	58	3H-LSD	-28	55	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	3H-LSD	-28	55	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	3H-LSD	-28	55	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	3H-LSD	-28	55	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	3H-LSD	-28	55	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		681	1465	72	3H-5HT	-354	39	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		681	1465	72	3H-LSD	-354	39	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	1465	72	3H-5HT	-354	39	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	1465	72	3H-LSD	-354	39	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	1465	72	3H-5HT	-354	39	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	1465	72	3H-LSD	-354	39	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	1465	72	3H-5HT	-354	39	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	1465	72	3H-LSD	-354	39	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	1465	72	3H-5HT	-354	39	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	1465	72	3H-LSD	-354	39	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		1209	1658	75	3H-5HT	-186	32	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		1209	1658	75	3H-LSD	-186	32	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		203	1658	75	3H-5HT	-186	32	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		203	1658	75	3H-LSD	-186	32	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		3386	1658	75	3H-5HT	-186	32	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		3386	1658	75	3H-LSD	-186	32	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		CHEMBL41	1658	75	3H-5HT	-186	32	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		CHEMBL41	1658	75	3H-LSD	-186	32	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		DB00472	1658	75	3H-5HT	-186	32	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		DB00472	1658	75	3H-LSD	-186	32	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		1204	1932	119	3H-5HT	-616	24	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1204	1932	119	3H-LSD	-616	24	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-5HT	-616	24	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-LSD	-616	24	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-5HT	-616	24	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-LSD	-616	24	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-5HT	-616	24	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-LSD	-616	24	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-5HT	-616	24	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-LSD	-616	24	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-5HT	-616	24	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-LSD	-616	24	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		12575	1988	30	3H-5HT	-660	17	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
		12575	1988	30	3H-LSD	-660	17	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
		54459	1988	30	3H-5HT	-660	17	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
		54459	1988	30	3H-LSD	-660	17	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
		CHEMBL10316	1988	30	3H-5HT	-660	17	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
		CHEMBL10316	1988	30	3H-LSD	-660	17	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
		1427	2013	54	3H-5HT	-97	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		1427	2013	54	3H-LSD	-97	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		357	2013	54	3H-5HT	-97	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		357	2013	54	3H-LSD	-97	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		3696	2013	54	3H-5HT	-97	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		3696	2013	54	3H-LSD	-97	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL11	2013	54	3H-5HT	-97	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL11	2013	54	3H-LSD	-97	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		DB00458	2013	54	3H-5HT	-97	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		DB00458	2013	54	3H-LSD	-97	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		1357	2485	139	3H-5HT	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1357	2485	139	3H-LSD	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1672	2485	139	3H-5HT	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		1672	2485	139	3H-LSD	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		224	2485	139	3H-5HT	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		224	2485	139	3H-LSD	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		896	2485	139	3H-5HT	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		896	2485	139	3H-LSD	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		CHEMBL45	2485	139	3H-5HT	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		CHEMBL45	2485	139	3H-LSD	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		DB01065	2485	139	3H-5HT	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		DB01065	2485	139	3H-LSD	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
		484	2858	51	3H-5HT	-1	35	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		484	2858	51	3H-LSD	-1	35	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		951	2858	51	3H-5HT	-1	35	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		951	2858	51	3H-LSD	-1	35	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		CHEMBL432	2858	51	3H-5HT	-1	35	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		CHEMBL432	2858	51	3H-LSD	-1	35	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		102484	2906	50	3H-5HT	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
		102484	2906	50	3H-LSD	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
		2149	2906	50	3H-5HT	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
		2149	2906	50	3H-LSD	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
		3396	2906	50	3H-5HT	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
		3396	2906	50	3H-LSD	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
		4581	2906	50	3H-5HT	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
		4581	2906	50	3H-LSD	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
		CHEMBL53929	2906	50	3H-5HT	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
		CHEMBL53929	2906	50	3H-LSD	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
		DB13251	2906	50	3H-5HT	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
		DB13251	2906	50	3H-LSD	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
		2176	3127	68	3H-5HT	-6165	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		2176	3127	68	3H-LSD	-6165	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		4828	3127	68	3H-5HT	-6165	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		4828	3127	68	3H-LSD	-6165	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		91	3127	68	3H-5HT	-6165	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		91	3127	68	3H-LSD	-6165	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		CHEMBL500	3127	68	3H-5HT	-6165	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		CHEMBL500	3127	68	3H-LSD	-6165	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		DB00960	3127	68	3H-5HT	-6165	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		DB00960	3127	68	3H-LSD	-6165	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		173	3262	95	3H-5HT	-11	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		173	3262	95	3H-LSD	-11	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		5011	3262	95	3H-5HT	-11	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		5011	3262	95	3H-LSD	-11	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		CHEMBL18772	3262	95	3H-5HT	-11	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		CHEMBL18772	3262	95	3H-LSD	-11	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		189	3492	39	3H-5CT	-416	17	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
		5163	3492	39	3H-5CT	-416	17	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
		CHEMBL297784	3492	39	3H-5CT	-416	17	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
		130	3500	47	35S-GTPGammaS	-275	13	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		3378093	3500	47	35S-GTPGammaS	-275	13	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		CHEMBL281350	3500	47	35S-GTPGammaS	-275	13	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		108182	4131	22	3H-5HT	-2	16	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
		108182	4131	22	3H-LSD	-2	16	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
		245	4131	22	3H-5HT	-2	16	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
		245	4131	22	3H-LSD	-2	16	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
		CHEMBL18041	4131	22	3H-5HT	-2	16	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
		CHEMBL18041	4131	22	3H-LSD	-2	16	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
		671690	27097	35	3H-5HT	2	10	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	313	2	0	3	3.8	CN1[C@H]2CC[C@@H]1CC(OC(=O)c1cc(Cl)cc(Cl)c1)C2	None
		671690	27097	35	3H-LSD	2	10	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	313	2	0	3	3.8	CN1[C@H]2CC[C@@H]1CC(OC(=O)c1cc(Cl)cc(Cl)c1)C2	None
		CHEMBL1365455	27097	35	3H-5HT	2	10	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	313	2	0	3	3.8	CN1[C@H]2CC[C@@H]1CC(OC(=O)c1cc(Cl)cc(Cl)c1)C2	None
		CHEMBL1365455	27097	35	3H-LSD	2	10	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	313	2	0	3	3.8	CN1[C@H]2CC[C@@H]1CC(OC(=O)c1cc(Cl)cc(Cl)c1)C2	None
		4595	176715	106	3H-5HT	-18	15	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	None
		4595	176715	106	3H-LSD	-18	15	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	None
		CHEMBL46	176715	106	3H-5HT	-18	15	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	None
		CHEMBL46	176715	106	3H-LSD	-18	15	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	None
		2771	195017	74	3H-5HT	-12	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		2771	195017	74	3H-LSD	-12	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL1200781	195017	74	3H-5HT	-12	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL1200781	195017	74	3H-LSD	-12	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL549	195017	74	3H-5HT	-12	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL549	195017	74	3H-LSD	-12	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		54841	203127	52	3H-5HT	-1	27	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	None
		CHEMBL641	203127	52	3H-5HT	-1	27	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	None
		2995	204405	53	3H-LSD	-141	23	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		2995	204405	53	3H-5HT	-141	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		2995	204405	53	3H-LSD	-141	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL1696	204405	53	3H-LSD	-141	23	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL1696	204405	53	3H-5HT	-141	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL1696	204405	53	3H-LSD	-141	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL72	204405	53	3H-LSD	-141	23	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL72	204405	53	3H-5HT	-141	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL72	204405	53	3H-LSD	-141	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		3337	206367	27	3H-5HT	-151	40	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		3337	206367	27	3H-LSD	-151	40	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	206367	27	3H-5HT	-151	40	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	206367	27	3H-LSD	-151	40	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	206367	27	3H-5HT	-151	40	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	206367	27	3H-LSD	-151	40	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	206367	27	3H-5HT	-151	40	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	206367	27	3H-LSD	-151	40	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	206367	27	3H-5HT	-151	40	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	206367	27	3H-LSD	-151	40	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		None	215971	0	125I-LSD	-616	15	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	473	7	0	5	3.5	COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O.Br	None
		None	215971	0	3H-5HT	-616	15	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	473	7	0	5	3.5	COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O.Br	None
		None	215971	0	3H-LSD	-616	15	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	473	7	0	5	3.5	COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O.Br	None
		86287410	215972	0	3H-5HT	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	312	2	1	4	2.3	CN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C	None
		86287410	215972	0	3H-LSD	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	312	2	1	4	2.3	CN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C	None
		None	215973	0	3H-5HT	-4	2	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	336	1	2	4	1.9	CN1C2CCC1CC(C2)NC(=O)N3C4=CC=CC=C4NC3=O.Cl	None
		None	215973	0	3H-LSD	-4	2	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	336	1	2	4	1.9	CN1C2CCC1CC(C2)NC(=O)N3C4=CC=CC=C4NC3=O.Cl	None
		None	215976	0	3H-5HT	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	298	2	1	4	1.9	CN1C2CCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C	None
		None	215976	0	3H-LSD	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	298	2	1	4	1.9	CN1C2CCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C	None
		3035240	215978	0	3H-5HT	-11	4	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	359	3	2	4	2.6	COC1=CC(=C(C=C1C(=O)NC2CCN3CCCC2C3)Cl)N.Cl	None
		3035240	215978	0	3H-LSD	-11	4	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	359	3	2	4	2.6	COC1=CC(=C(C=C1C(=O)NC2CCN3CCCC2C3)Cl)N.Cl	None
		None	216011	0	3H-5HT	-43	5	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	367	2	1	6	2.4	CN1C2CCC1CC(C2)OC(=O)N3C4=C(C=CC(=C4)OC)NC3=O.Cl	None
		None	216011	0	3H-LSD	-43	5	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	367	2	1	6	2.4	CN1C2CCC1CC(C2)OC(=O)N3C4=C(C=CC(=C4)OC)NC3=O.Cl	None
		1576	216326	0	3H-LSD	-1	40	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	163	3	1	2	1.5	CC(C(=O)C1=CC=CC=C1)NC	None
		None	216450	0	Functional	-66	28	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
		None	216450	0	UNDEFINED	-66	28	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
		3075702	217332	0	3H-LSD	-2	37	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	198	3	1	3	1.5	C1CNC1COC2=CN=C(C=C2)Cl	None
		1028	291	71	3H-5HT	-1862	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		139148732	291	71	3H-5HT	-1862	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		479	291	71	3H-5HT	-1862	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		5816	291	71	3H-5HT	-1862	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		CHEMBL679	291	71	3H-5HT	-1862	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		DB00668	291	71	3H-5HT	-1862	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		135398737	958	93	3H-5CT	-13	89	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-5CT	-13	89	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-5CT	-13	89	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-5CT	-13	89	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-5CT	-13	89	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		132	1275	13	3H-5HT	-281838	15	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	287	5	3	4	2.2	N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2	None
		155346	1275	13	3H-5HT	-281838	15	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	287	5	3	4	2.2	N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2	None
		CHEMBL378501	1275	13	3H-5HT	-281838	15	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	287	5	3	4	2.2	N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2	None
		681	1465	72	3H-5HT	-1995	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		681	1465	72	3H-5HT	-354	39	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	1465	72	3H-5HT	-1995	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	1465	72	3H-5HT	-354	39	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	1465	72	3H-5HT	-1995	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	1465	72	3H-5HT	-354	39	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	1465	72	3H-5HT	-1995	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	1465	72	3H-5HT	-354	39	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	1465	72	3H-5HT	-1995	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	1465	72	3H-5HT	-354	39	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		107780	1844	54	3H-LSD	-2691	17	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		14	1844	54	3H-LSD	-2691	17	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		CHEMBL15928	1844	54	3H-LSD	-2691	17	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		1204	1932	119	3H-5HT	-1949	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1204	1932	119	3H-5HT	-616	24	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-5HT	-1949	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-5HT	-616	24	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-5HT	-1949	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-5HT	-616	24	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-5HT	-1949	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-5HT	-616	24	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-5HT	-1949	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-5HT	-616	24	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-5HT	-1949	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-5HT	-616	24	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1782	2518	84	3H-5HT	-676	22	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		241	2518	84	3H-5HT	-676	22	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		4168	2518	84	3H-5HT	-676	22	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		CHEMBL86	2518	84	3H-5HT	-676	22	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		DB01233	2518	84	3H-5HT	-676	22	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		135	2532	43	3H-5HT	-50	58	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-5HT	-50	58	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-5HT	-50	58	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-5HT	-50	58	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-5HT	-50	58	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		484	2858	51	3H-5HT	-24	35	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		951	2858	51	3H-5HT	-24	35	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		CHEMBL432	2858	51	3H-5HT	-24	35	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		127	3126	52	3H-5CT	-22908	15	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C	None
		688095	3126	52	3H-5CT	-22908	15	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C	None
		CHEMBL117405	3126	52	3H-5CT	-22908	15	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C	None
		2176	3127	68	3H-5HT	-31622	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		2176	3127	68	3H-MESULERGINE	-6165	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		4828	3127	68	3H-5HT	-31622	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		4828	3127	68	3H-MESULERGINE	-6165	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		91	3127	68	3H-5HT	-31622	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		91	3127	68	3H-MESULERGINE	-6165	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		CHEMBL500	3127	68	3H-5HT	-31622	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		CHEMBL500	3127	68	3H-MESULERGINE	-6165	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		DB00960	3127	68	3H-5HT	-31622	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		DB00960	3127	68	3H-MESULERGINE	-6165	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		2274	3173	58	3H-5CT	-4786	31	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4917	3173	58	3H-5CT	-4786	31	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		7279	3173	58	3H-5CT	-4786	31	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL728	3173	58	3H-5CT	-4786	31	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00433	3173	58	3H-5CT	-4786	31	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		243	3202	91	3H-5HT	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		3052762	3202	91	3H-5HT	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		3502	3202	91	3H-5HT	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		CHEMBL117287	3202	91	3H-5HT	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		DB06480	3202	91	3H-5HT	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		128563	3464	33	3H-LSD	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		1666	3464	33	3H-LSD	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		CHEMBL445332	3464	33	3H-LSD	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		DB12327	3464	33	3H-LSD	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		28	3496	46	3H-5CT	-6025	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		3292447	3496	46	3H-5CT	-6025	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		CHEMBL20963	3496	46	3H-5CT	-6025	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		6917970	3691	61	3H-LSD	-2290	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		8370	3691	61	3H-LSD	-2290	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		CHEMBL487387	3691	61	3H-LSD	-2290	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		214	3860	58	3H-5CT	-4570	30	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2740	3860	58	3H-5CT	-4570	30	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5566	3860	58	3H-5CT	-4570	30	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		66064	3860	58	3H-5CT	-4570	30	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL422	3860	58	3H-5CT	-4570	30	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00831	3860	58	3H-5CT	-4570	30	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		108182	4131	22	3H-5HT	-32	16	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
		245	4131	22	3H-5HT	-32	16	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
		CHEMBL18041	4131	22	3H-5HT	-32	16	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
		2662	11384	131	3H-LSD	-41	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
		CHEMBL118	11384	131	3H-LSD	-41	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
		5090	15561	106	3H-LSD	-1348	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
		CHEMBL122	15561	106	3H-LSD	-1348	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
		10297	27112	30	3H-LSD	-38	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	C[C@H](N)[C@H](O)c1ccccc1	None
		CHEMBL136560	27112	30	3H-LSD	-38	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	C[C@H](N)[C@H](O)c1ccccc1	None
		156391	46800	99	3H-LSD	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		CHEMBL1200806	46800	99	3H-LSD	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		CHEMBL154	46800	99	3H-LSD	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		2244	94233	100	3H-LSD	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	180	2	1	3	1.3	CC(=O)Oc1ccccc1C(=O)O	None
		CHEMBL25	94233	100	3H-LSD	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	180	2	1	3	1.3	CC(=O)Oc1ccccc1C(=O)O	None
		3663	99967	83	3H-LSD	-288	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	504	0	6	8	5.1	Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65	None
		CHEMBL286494	99967	83	3H-LSD	-288	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	504	0	6	8	5.1	Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65	None
		446220	133521	14	3H-LSD	-1778	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	3	0	5	1.9	COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C	None
		CHEMBL370805	133521	14	3H-LSD	-1778	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	3	0	5	1.9	COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C	None
		1615	167791	24	3H-LSD	-26	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
		CHEMBL43048	167791	24	3H-LSD	-26	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
		5280343	188275	124	3H-LSD	-147	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
		CHEMBL1520590	188275	124	3H-LSD	-147	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
		CHEMBL50	188275	124	3H-LSD	-147	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
		3672	192533	136	3H-LSD	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	206	4	1	1	3.1	CC(C)Cc1ccc(C(C)C(=O)O)cc1	None
		CHEMBL521	192533	136	3H-LSD	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	206	4	1	1	3.1	CC(C)Cc1ccc(C(C)C(=O)O)cc1	None
		4495	196535	92	3H-LSD	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
		CHEMBL56367	196535	92	3H-LSD	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
		54677470	200551	115	3H-LSD	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		CHEMBL1256873	200551	115	3H-LSD	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		CHEMBL599	200551	115	3H-LSD	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		162265	202274	22	3H-LSD	-16	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		4786	202274	22	3H-LSD	-16	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		CHEMBL61006	202274	22	3H-LSD	-16	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		5281600	203025	92	3H-LSD	-275	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
		CHEMBL63354	203025	92	3H-LSD	-275	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
		5656	203066	87	3H-5HT	-79	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		CHEMBL637	203066	87	3H-5HT	-79	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		1973	203483	15	3H-LSD	-3	36	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
		CHEMBL1394464	203483	15	3H-LSD	-3	36	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
		CHEMBL66089	203483	15	3H-LSD	-3	36	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
		3821	204718	17	3H-LSD	-1	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	237	2	1	2	2.9	CNC1(c2ccccc2Cl)CCCCC1=O	None
		CHEMBL742	204718	17	3H-LSD	-1	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	237	2	1	2	2.9	CNC1(c2ccccc2Cl)CCCCC1=O	None
		4158	205341	21	3H-LSD	-141	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
		CHEMBL1722	205341	21	3H-LSD	-141	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
		CHEMBL796	205341	21	3H-LSD	-141	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
		4054	205501	72	3H-LSD	-1	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
		CHEMBL1699	205501	72	3H-LSD	-1	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
		CHEMBL807	205501	72	3H-LSD	-1	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
		119607	206203	113	3H-LSD	-97	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	None
		CHEMBL865	206203	113	3H-LSD	-97	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	None
		3337	206367	27	3H-LSD	-169	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	206367	27	3H-LSD	-169	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	206367	27	3H-LSD	-169	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	206367	27	3H-LSD	-169	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	206367	27	3H-LSD	-169	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		57174031	215940	0	3H-5HT	-1778	19	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	2	1	3	3.0	CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43	None
		None	215993	0	3H-LSD	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	2	0	4	3.6	CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C.Cl	None
		104911	216019	0	3H-LSD	-41686	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	530	7	0	5	5.1	COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl	None
		25137849	216179	0	3H-LSD	-1	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
		71290	216179	0	3H-LSD	-1	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
		None	216214	0	3H-5-CABOXAMIDOTRYPTAMINE	-933	14	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	438	5	1	4	4.8	C1CC(CCC1CCN2CCC3=C(C2)C=CC(=C3)C#N)NC(=O)C4=CC=NC5=CC=CC=C45	None
		None	216311	0	3H-LSD	-1	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	240	7	4	6	-0.8	C(C(C(=O)O)N)SSCC(C(=O)O)N	None
		None	216312	0	3H-LSD	-1	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	4	2	3	0.2	CSCCC(C(=O)O)N	None
		None	216313	0	3H-LSD	-1	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	135	3	3	3	-0.3	C(CS)C(C(=O)O)N	None
		None	216314	0	3H-LSD	-1	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	121	2	3	3	-0.7	C(C(C(=O)O)N)S	None
		None	216315	0	3H-LSD	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	117	0	1	3	-0.0	C1CSC(=O)C1N	None
		None	216316	0	3H-LSD	-1	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	3	3	3	-1.4	C(C(C(=O)O)N)S(=O)O	None
		None	216317	0	3H-LSD	-1	38	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	3	3	4	-1.7	C(C(C(=O)O)N)S(=O)(=O)O	None
		None	216318	0	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	4	3	4	-1.3	C(CS(=O)(=O)O)C(C(=O)O)N	None
		None	216327	0	3H-LSD	-16	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	536	11	1	4	9.0	CC(C)C(=O)C12C(=O)C(=C(C(C1=O)(CC(C2(C)CCC=C(C)C)CC=C(C)C)CC=C(C)C)O)CC=C(C)C	None
		4978	216328	0	3H-LSD	-16	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	520	1	7	9	4.3	CC1=CC(=C2C3=C1C4=C5C(=C(C=C4CO)O)C(=O)C6=C(C=C(C7=C6C5=C3C8=C7C(=CC(=C8C2=O)O)O)O)O)O	None
		None	216329	0	3H-LSD	-3	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	464	4	8	12	-0.6	C1=CC(=C(C=C1C2=C(C(=C3C(=CC(=O)C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O)O	None
		None	216330	0	3H-LSD	-281	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	610	6	10	16	-1.7	CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O)O)O)O)O)O	None
		None	216331	0	3H-LSD	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	448	3	7	11	0.4	CC1C(C(C(C(O1)OC2=C(OC3=CC(=O)C=C(C3=C2O)O)C4=CC(=C(C=C4)O)O)O)O)O	None
		135269	216389	0	3H-LSD	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	222	5	1	3	2.5	CCCCC(=O)OC1=CC=CC=C1C(=O)O	None
		23681059	216390	0	3H-LSD	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O	None
		5018304	216391	0	3H-LSD	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	317	4	1	3	0.0	C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+]	None
		84003	216392	0	3H-LSD	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	376	6	5	7	-0.0	C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O	None
		123619	216393	0	3H-LSD	-1412	26	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	358	3	0	4	4.2	CC1=NC=C(C=C1)C2=NC=C(C=C2C3=CC=C(C=C3)S(=O)(=O)C)Cl	None
		119828	216394	0	3H-LSD	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	370	5	1	5	3.5	CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C	None
		None	216395	0	3H-LSD	-7	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	517	8	2	5	5.2	CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)NCCC4=CC=C(C=C4)NC(=O)C	None
		None	216489	0	3H-LSD	-4570	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	347	6	0	3	5.0	CC(=O)N(CC1=CC=CC=C1OC)C2=CC=CC=C2OC3=CC=CC=C3	None
		11957566	184	25	3H-5HT	-549	9	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	None
		1219	184	25	3H-5HT	-549	9	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	None
		3296	184	25	3H-5HT	-549	9	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	None
		950	184	25	3H-5HT	-549	9	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	None
		CHEMBL285755	184	25	3H-5HT	-549	9	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	None
		135398745	2914	112	3H-LSD	-34	65	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-LSD	-34	65	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-LSD	-34	65	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-LSD	-34	65	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		135398745	2914	112	3H-LSD	-95	65	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-LSD	-95	65	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-LSD	-95	65	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-LSD	-95	65	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		135398745	2914	112	3H-LSD	-95	65	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-LSD	-95	65	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-LSD	-95	65	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-LSD	-95	65	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		135	2532	43	3H-5CT	-138	58	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-5CT	-138	58	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-5CT	-138	58	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-5CT	-138	58	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-5CT	-138	58	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		2470	3653	50	3H-5HT	-1258	59	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-5HT	-1258	59	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-5HT	-1258	59	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-5HT	-1258	59	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-5HT	-1258	59	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		265	128	0	3H-5CT	-4	3	Guinea pig	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	266	5	2	2	3.2	NCCc1c[nH]c2c1cc(OCc1ccccc1)cc2	None
		89576	128	0	3H-5CT	-4	3	Guinea pig	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	266	5	2	2	3.2	NCCc1c[nH]c2c1cc(OCc1ccccc1)cc2	None
		CHEMBL1288652	128	0	3H-5CT	-4	3	Guinea pig	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	266	5	2	2	3.2	NCCc1c[nH]c2c1cc(OCc1ccccc1)cc2	None
		179	400	115	3H-LSD	-9	49	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		2159	400	115	3H-LSD	-9	49	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		963	400	115	3H-LSD	-9	49	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		CHEMBL243712	400	115	3H-LSD	-9	49	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		DB06288	400	115	3H-LSD	-9	49	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		2470	3653	50	3H-5HT	-1258	59	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-5HT	-1258	59	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-5HT	-1258	59	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-5HT	-1258	59	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-5HT	-1258	59	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		1353	1911	93	3H-LSD	-263	83	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-LSD	-263	83	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-LSD	-263	83	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-LSD	-263	83	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-LSD	-263	83	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		135	2532	43	125I-LSD	-50	58	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	125I-LSD	-50	58	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	125I-LSD	-50	58	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	125I-LSD	-50	58	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	125I-LSD	-50	58	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		3294	2006	111	3H-MESULERGINE	-41	45	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	2006	111	3H-MESULERGINE	-41	45	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	2006	111	3H-MESULERGINE	-41	45	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	2006	111	3H-MESULERGINE	-41	45	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	2006	111	3H-MESULERGINE	-41	45	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		135	2532	43	125I-LSD	-50	58	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	125I-LSD	-50	58	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	125I-LSD	-50	58	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	125I-LSD	-50	58	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	125I-LSD	-50	58	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1353	1911	93	3H-LSD	-263	83	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-LSD	-263	83	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-LSD	-263	83	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-LSD	-263	83	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-LSD	-263	83	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1353	1911	93	3H-5HT	-263	83	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-5HT	-263	83	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-5HT	-263	83	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-5HT	-263	83	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-5HT	-263	83	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		119570	3159	96	3H-LSD	-154	40	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		2233	3159	96	3H-LSD	-154	40	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		953	3159	96	3H-LSD	-154	40	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		CHEMBL301265	3159	96	3H-LSD	-154	40	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		DB00413	3159	96	3H-LSD	-154	40	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		103	4153	61	3H-LSD	-6	53	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	4153	61	3H-LSD	-6	53	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	4153	61	3H-LSD	-6	53	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	4153	61	3H-LSD	-6	53	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	4153	61	3H-LSD	-6	53	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		11954259	215979	0	3H-LSD	-39	43	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
		134	2514	24	125I-LSD	-18	67	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	125I-LSD	-18	67	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	125I-LSD	-18	67	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	125I-LSD	-18	67	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	125I-LSD	-18	67	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		134	2514	24	3H-5HT	-9	67	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		134	2514	24	125I-LSD	-18	67	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-5HT	-9	67	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	125I-LSD	-18	67	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-5HT	-9	67	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	125I-LSD	-18	67	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-5HT	-9	67	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	125I-LSD	-18	67	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-5HT	-9	67	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	125I-LSD	-18	67	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		206	2493	16	3H-MESULERGINE	-15	25	Guinea pig	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		68848	2493	16	3H-MESULERGINE	-15	25	Guinea pig	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		CHEMBL12314	2493	16	3H-MESULERGINE	-15	25	Guinea pig	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		134	2514	24	3H-LSD	-18	67	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-LSD	-18	67	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-LSD	-18	67	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-LSD	-18	67	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-LSD	-18	67	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		21830793	91835	10	3H-8-OH-DPAT	-85	45	Bovine	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	None
		CHEMBL2413154	91835	10	3H-8-OH-DPAT	-85	45	Bovine	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	None
		135398745	2914	112	3H-5HT	-61	65	Mouse	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-5HT	-61	65	Mouse	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-5HT	-61	65	Mouse	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-5HT	-61	65	Mouse	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		180	401	56	125I-LSD	-125	40	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		200	401	56	125I-LSD	-125	40	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2160	401	56	125I-LSD	-125	40	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL629	401	56	125I-LSD	-125	40	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		DB00321	401	56	125I-LSD	-125	40	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		277	1301	62	3H-5HT	-63	50	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	1301	62	3H-5HT	-63	50	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	1301	62	3H-5HT	-63	50	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	1301	62	3H-5HT	-63	50	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	1301	62	3H-5HT	-63	50	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		277	1301	62	3H-5HT	-63	50	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	1301	62	3H-5HT	-63	50	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	1301	62	3H-5HT	-63	50	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	1301	62	3H-5HT	-63	50	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	1301	62	3H-5HT	-63	50	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		1346	83	117	3H-5HT	-147	9	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	None
		280	83	117	3H-5HT	-147	9	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	None
		9899402	83	117	3H-5HT	-147	9	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	None
		CHEMBL9666	83	117	3H-5HT	-147	9	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	None
		180	401	56	3H-LSD	-125	40	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		200	401	56	3H-LSD	-125	40	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2160	401	56	3H-LSD	-125	40	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL629	401	56	3H-LSD	-125	40	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		DB00321	401	56	3H-LSD	-125	40	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		31101	729	40	3H-5HT	-181	36	Mouse	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		35	729	40	3H-5HT	-181	36	Mouse	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		403	729	40	3H-5HT	-181	36	Mouse	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		CHEMBL493	729	40	3H-5HT	-181	36	Mouse	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		DB01200	729	40	3H-5HT	-181	36	Mouse	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		277	1301	62	3H-5CT	-301	50	Guinea pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	1301	62	3H-5CT	-301	50	Guinea pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	1301	62	3H-5CT	-301	50	Guinea pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	1301	62	3H-5CT	-301	50	Guinea pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	1301	62	3H-5CT	-301	50	Guinea pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		3652	4097	79	3H-5CT	-6	18	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		57	4097	79	3H-5CT	-6	18	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		60809	4097	79	3H-5CT	-6	18	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		CHEMBL21536	4097	79	3H-5CT	-6	18	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		DB15357	4097	79	3H-5CT	-6	18	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		1574	81	60	3H-5HT	-13	21	Guinea pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
		218	81	60	3H-5HT	-13	21	Guinea pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
		CHEMBL266591	81	60	3H-5HT	-13	21	Guinea pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
		2398	954	62	3H-5HT	-15	29	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		2801	954	62	3H-5HT	-15	29	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		701	954	62	3H-5HT	-15	29	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		CHEMBL415	954	62	3H-5HT	-15	29	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		DB01242	954	62	3H-5HT	-15	29	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		11954224	215953	0	3H- LSD	-18197	58	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		11954224	215953	0	3H-LSD	-18197	58	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		134	2514	24	3H-5HT	-18	67	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-5HT	-18	67	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-5HT	-18	67	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-5HT	-18	67	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-5HT	-18	67	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		135398737	958	93	125I-LSD	-7	89	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	125I-LSD	-7	89	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	125I-LSD	-7	89	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	125I-LSD	-7	89	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	125I-LSD	-7	89	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		122	1437	9	3H-5CT	-1	11	Guinea pig	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
		156314	1437	9	3H-5CT	-1	11	Guinea pig	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL1332062	1437	9	3H-5CT	-1	11	Guinea pig	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
		134	2514	24	3H-5HT	-18	67	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-5HT	-18	67	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-5HT	-18	67	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-5HT	-18	67	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-5HT	-18	67	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		135398737	958	93	125I-LSD	-7	89	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	125I-LSD	-7	89	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	125I-LSD	-7	89	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	125I-LSD	-7	89	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	125I-LSD	-7	89	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		24768524	93202	0	UNDEFINED	-4	3	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	423	8	1	3	4.7	O=C(CCCCCN1CCN(c2ccccc2F)CC1)NC1CCCc2ccccc21	None
		CHEMBL244577	93202	0	UNDEFINED	-4	3	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	423	8	1	3	4.7	O=C(CCCCCN1CCN(c2ccccc2F)CC1)NC1CCCc2ccccc21	None
		1613	2348	53	3H-5HT	-14	44	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	2348	53	3H-5HT	-14	44	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	2348	53	3H-5HT	-14	44	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	2348	53	3H-5HT	-14	44	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	2348	53	3H-5HT	-14	44	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		2337	3256	77	3H-LSD	-15	62	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	3H-LSD	-15	62	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	3H-LSD	-15	62	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	3H-LSD	-15	62	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	3H-LSD	-15	62	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		1524	2181	96	3H-5HT	-501	52	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	3H-5HT	-501	52	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	3H-5HT	-501	52	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	3H-5HT	-501	52	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	3H-5HT	-501	52	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	3H-5HT	-501	52	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		1220	187	55	3H-5CT	-51	44	Guinea pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	187	55	3H-5CT	-51	44	Guinea pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	187	55	3H-5CT	-51	44	Guinea pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	187	55	3H-5CT	-51	44	Guinea pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		179	400	115	3H-5CT	-9	49	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		2159	400	115	3H-5CT	-9	49	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		963	400	115	3H-5CT	-9	49	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		CHEMBL243712	400	115	3H-5CT	-9	49	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		DB06288	400	115	3H-5CT	-9	49	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		11954224	215953	0	3H-5CT	-1174	58	Guinea pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		242	470	124	3H-LSD	-14	51	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	470	124	3H-LSD	-14	51	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	470	124	3H-LSD	-14	51	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	470	124	3H-LSD	-14	51	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	470	124	3H-LSD	-14	51	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		135409468	2035	69	3H-LSD	-5	39	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		333	2035	69	3H-LSD	-5	39	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		CHEMBL845	2035	69	3H-LSD	-5	39	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		191	403	98	3H-5CT	-380	29	Guinea pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		201	403	98	3H-5CT	-380	29	Guinea pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		2170	403	98	3H-5CT	-380	29	Guinea pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		CHEMBL1113	403	98	3H-5CT	-380	29	Guinea pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		DB00543	403	98	3H-5CT	-380	29	Guinea pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		214	3860	58	3H-5CT	-4570	30	Guinea pig	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2740	3860	58	3H-5CT	-4570	30	Guinea pig	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5566	3860	58	3H-5CT	-4570	30	Guinea pig	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		66064	3860	58	3H-5CT	-4570	30	Guinea pig	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL422	3860	58	3H-5CT	-4570	30	Guinea pig	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00831	3860	58	3H-5CT	-4570	30	Guinea pig	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		135398737	958	93	3H-5CT	-34	89	Guinea pig	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-5CT	-34	89	Guinea pig	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-5CT	-34	89	Guinea pig	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-5CT	-34	89	Guinea pig	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-5CT	-34	89	Guinea pig	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		1150	3878	121	3H-5HT	-6	25	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		125	3878	121	3H-5HT	-6	25	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		CHEMBL6640	3878	121	3H-5HT	-6	25	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		DB08653	3878	121	3H-5HT	-6	25	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		25107581	192631	0	UNDEFINED	-14	3	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	505	12	1	7	3.7	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	None
		CHEMBL521687	192631	0	UNDEFINED	-14	3	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	505	12	1	7	3.7	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	None
		1150	3878	121	3H-5HT	-6	25	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		125	3878	121	3H-5HT	-6	25	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		CHEMBL6640	3878	121	3H-5HT	-6	25	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		DB08653	3878	121	3H-5HT	-6	25	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		5074	3332	80	3H-5HT	-36	30	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		97	3332	80	3H-5HT	-36	30	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		CHEMBL267777	3332	80	3H-5HT	-36	30	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		DB12693	3332	80	3H-5HT	-36	30	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		11954259	215979	0	3H-LSD	-51	43	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
		5074	3332	80	3H-5HT	-36	30	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		97	3332	80	3H-5HT	-36	30	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		CHEMBL267777	3332	80	3H-5HT	-36	30	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		DB12693	3332	80	3H-5HT	-36	30	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		206	2493	16	3H-5CT	-15	25	Guinea pig	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		68848	2493	16	3H-5CT	-15	25	Guinea pig	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		CHEMBL12314	2493	16	3H-5CT	-15	25	Guinea pig	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		None	215943	0	3H-5CT	-17	11	Guinea pig	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(CC)C(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C	None
		11954259	215979	0	3H-LSD	-51	43	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
		2181	3128	46	3H-5HT	-125	35	Mouse	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		4830	3128	46	3H-5HT	-125	35	Mouse	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		92	3128	46	3H-5HT	-125	35	Mouse	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		CHEMBL440294	3128	46	3H-5HT	-125	35	Mouse	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		DB09286	3128	46	3H-5HT	-125	35	Mouse	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		None	215938	0	3H-5HT	-2511	21	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	583	4	3	6	2.1	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C	None
		None	215938	0	UNDEFINED	-2511	21	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	583	4	3	6	2.1	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C	None
		2402	3370	62	3H-LSD	-6	24	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		5095	3370	62	3H-LSD	-6	24	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		7295	3370	62	3H-LSD	-6	24	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		CHEMBL589	3370	62	3H-LSD	-6	24	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		DB00268	3370	62	3H-LSD	-6	24	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		135398745	2914	112	3H-LSD	-34	65	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-LSD	-34	65	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-LSD	-34	65	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-LSD	-34	65	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		135398745	2914	112	3H-LSD	-95	65	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-LSD	-95	65	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-LSD	-95	65	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-LSD	-95	65	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		133	2496	52	125I-LSD	-16	42	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	2496	52	125I-LSD	-16	42	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	2496	52	125I-LSD	-16	42	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	2496	52	125I-LSD	-16	42	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	2496	52	125I-LSD	-16	42	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		133	2496	52	125I-LSD	-16	42	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	2496	52	125I-LSD	-16	42	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	2496	52	125I-LSD	-16	42	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	2496	52	125I-LSD	-16	42	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	2496	52	125I-LSD	-16	42	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1150	3878	121	3H-5HT	1	25	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		125	3878	121	3H-5HT	1	25	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		CHEMBL6640	3878	121	3H-5HT	1	25	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		DB08653	3878	121	3H-5HT	1	25	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		1150	3878	121	3H-5HT	1	25	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		125	3878	121	3H-5HT	1	25	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		CHEMBL6640	3878	121	3H-5HT	1	25	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		DB08653	3878	121	3H-5HT	1	25	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		7153	98020	77	3H-LSD	-8	34	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	98020	77	3H-LSD	-8	34	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		2337	3256	77	3H-LSD	-28	62	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	3H-LSD	-28	62	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	3H-LSD	-28	62	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	3H-LSD	-28	62	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	3H-LSD	-28	62	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		134	2514	24	125I-LSD	-18	67	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	125I-LSD	-18	67	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	125I-LSD	-18	67	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	125I-LSD	-18	67	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	125I-LSD	-18	67	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		11954224	215953	0	125I-LSD	-245	58	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		134	2514	24	125I-LSD	-18	67	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	125I-LSD	-18	67	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	125I-LSD	-18	67	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	125I-LSD	-18	67	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	125I-LSD	-18	67	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		11954224	215953	0	125I-LSD	-245	58	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		2105	3054	37	3H-5CT	-11	33	Guinea pig	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		47811	3054	37	3H-5CT	-11	33	Guinea pig	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		48	3054	37	3H-5CT	-11	33	Guinea pig	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		CHEMBL531	3054	37	3H-5CT	-11	33	Guinea pig	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		DB01186	3054	37	3H-5CT	-11	33	Guinea pig	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		135398737	958	93	3H-LSD	-13	89	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-LSD	-13	89	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-LSD	-13	89	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-LSD	-13	89	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-LSD	-13	89	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		1613	2348	53	125I-LSD	-14	44	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	2348	53	125I-LSD	-14	44	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	2348	53	125I-LSD	-14	44	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	2348	53	125I-LSD	-14	44	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	2348	53	125I-LSD	-14	44	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		None	216379	0	3H-LSD	-199	11	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	243	3	1	4	2.7	CCC1=CC2=C(O1)C=CC3=C2N(N=C3)CC(C)N	None
		2337	3256	77	3H-LSD	-28	62	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	3H-LSD	-28	62	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	3H-LSD	-28	62	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	3H-LSD	-28	62	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	3H-LSD	-28	62	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		213	3853	55	3H-LSD	-9	44	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		2717	3853	55	3H-LSD	-9	44	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		5533	3853	55	3H-LSD	-9	44	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		CHEMBL621	3853	55	3H-LSD	-9	44	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		DB00656	3853	55	3H-LSD	-9	44	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		11675876	187514	0	UNDEFINED	-54	3	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	407	8	0	4	3.9	COc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	None
		CHEMBL494316	187514	0	UNDEFINED	-54	3	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	407	8	0	4	3.9	COc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	None
		135398737	958	93	3H-5-CT	-13	89	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135398737	958	93	3H-LSD	-13	89	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135398737	958	93	[3H]-5-CT	-13	89	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-5-CT	-13	89	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-LSD	-13	89	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	[3H]-5-CT	-13	89	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-5-CT	-13	89	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-LSD	-13	89	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	[3H]-5-CT	-13	89	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-5-CT	-13	89	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-LSD	-13	89	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	[3H]-5-CT	-13	89	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-5-CT	-13	89	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-LSD	-13	89	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	[3H]-5-CT	-13	89	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		206	2493	16	3H-5HT	-10	25	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		68848	2493	16	3H-5HT	-10	25	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		CHEMBL12314	2493	16	3H-5HT	-10	25	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		1342	35	49	3H-5HT	-13	19	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		3	35	49	3H-5HT	-13	19	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		CHEMBL277120	35	49	3H-5HT	-13	19	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		206	2493	16	3H-5HT	-10	25	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		68848	2493	16	3H-5HT	-10	25	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		CHEMBL12314	2493	16	3H-5HT	-10	25	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		283	3130	57	3H-5CT	-28	12	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
		4847	3130	57	3H-5CT	-28	12	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
		CHEMBL18331	3130	57	3H-5CT	-28	12	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
		1342	35	49	3H-5HT	-13	19	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		3	35	49	3H-5HT	-13	19	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		CHEMBL277120	35	49	3H-5HT	-13	19	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		1588	2325	27	3H-5CT	-21	44	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		28864	2325	27	3H-5CT	-21	44	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		43	2325	27	3H-5CT	-21	44	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL157138	2325	27	3H-5CT	-21	44	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB00589	2325	27	3H-5CT	-21	44	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		2337	3256	77	3H-LSD	-28	62	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	3H-LSD	-28	62	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	3H-LSD	-28	62	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	3H-LSD	-28	62	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	3H-LSD	-28	62	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		135398745	2914	112	3H-5-CT	-95	65	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-5-CT	-95	65	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-5-CT	-95	65	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-5-CT	-95	65	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		191	403	98	3H-5CT	-380	29	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		201	403	98	3H-5CT	-380	29	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		2170	403	98	3H-5CT	-380	29	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		CHEMBL1113	403	98	3H-5CT	-380	29	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		DB00543	403	98	3H-5CT	-380	29	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		1150	3878	121	3H-5CT	-1	25	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		125	3878	121	3H-5CT	-1	25	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		CHEMBL6640	3878	121	3H-5CT	-1	25	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		DB08653	3878	121	3H-5CT	-1	25	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		135398737	958	93	3H-LSD	-7	89	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-LSD	-7	89	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-LSD	-7	89	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-LSD	-7	89	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-LSD	-7	89	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		10257	738	31	3H-5HT	-13	19	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
		144	738	31	3H-5HT	-13	19	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
		CHEMBL416526	738	31	3H-5HT	-13	19	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
		DB01445	738	31	3H-5HT	-13	19	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
		2726	919	68	3H-LSD	-13	72	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-LSD	-13	72	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-LSD	-13	72	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-LSD	-13	72	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-LSD	-13	72	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		5074	3332	80	3H-LSD	-36	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		97	3332	80	3H-LSD	-36	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		CHEMBL267777	3332	80	3H-LSD	-36	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		DB12693	3332	80	3H-LSD	-36	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		2470	3653	50	UNDEFINED	-389	59	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	UNDEFINED	-389	59	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	UNDEFINED	-389	59	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	UNDEFINED	-389	59	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	UNDEFINED	-389	59	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5074	3332	80	3H-5CT	-61	30	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		97	3332	80	3H-5CT	-61	30	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		CHEMBL267777	3332	80	3H-5CT	-61	30	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		DB12693	3332	80	3H-5CT	-61	30	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		6852400	215937	0	3H-5CT	-1023	22	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		73759726	215937	0	3H-5CT	-1023	22	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		12016890	190776	6	3H-5HT	-3235	11	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	318	4	1	3	2.6	NC(=O)c1ccc(F)c2c1CC(N(C1CCC1)C1CCC1)CO2	None
		CHEMBL5183389	190776	6	3H-5HT	-3235	11	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	318	4	1	3	2.6	NC(=O)c1ccc(F)c2c1CC(N(C1CCC1)C1CCC1)CO2	None
		2274	3173	58	3H-LSD	-93	31	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4917	3173	58	3H-LSD	-93	31	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		7279	3173	58	3H-LSD	-93	31	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL728	3173	58	3H-LSD	-93	31	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00433	3173	58	3H-LSD	-93	31	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		1621	2429	17	3H-5HT	-34	45	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		17	2429	17	3H-5HT	-34	45	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		5761	2429	17	3H-5HT	-34	45	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL263881	2429	17	3H-5HT	-34	45	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB04829	2429	17	3H-5HT	-34	45	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		1524	2181	96	3H-LSD	-169	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	3H-LSD	-169	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	3H-LSD	-169	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	3H-LSD	-169	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	3H-LSD	-169	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	3H-LSD	-169	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		1220	187	55	3H-5HT	-75	44	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	187	55	3H-5HT	-75	44	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	187	55	3H-5HT	-75	44	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	187	55	3H-5HT	-75	44	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		133	2496	52	3H-LSD	-16	42	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	2496	52	3H-LSD	-16	42	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	2496	52	3H-LSD	-16	42	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	2496	52	3H-LSD	-16	42	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	2496	52	3H-LSD	-16	42	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		133	2496	52	125I-LSD	-16	42	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	2496	52	125I-LSD	-16	42	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	2496	52	125I-LSD	-16	42	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	2496	52	125I-LSD	-16	42	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	2496	52	125I-LSD	-16	42	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		5	139	72	3H-5-HT	-3	54	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-5-HT	-3	54	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-5-HT	-3	54	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-5-HT	-3	54	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		17676	7072	29	3H-LSD	30	3	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	None
		5281082	7072	29	3H-LSD	30	3	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	None
		CHEMBL1085	7072	29	3H-LSD	30	3	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	None
		1238	203174	24	3H-5CT	-13	16	Guinea pig	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
		CHEMBL64249	203174	24	3H-5CT	-13	16	Guinea pig	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
		115237	55585	119	3H-LSD	-20	54	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	55585	119	3H-LSD	-20	54	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		2389	3331	118	3H-LSD	-8	67	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-LSD	-8	67	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-LSD	-8	67	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-LSD	-8	67	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-LSD	-8	67	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		10090005	215986	0	3H-LSD	-3	11	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	361	1	0	3	4.4	CN1CCN(CC1)C2=CC3=C(C=CC(=C3)Cl)C(=CC#N)C4=CC=CC=C42	None
		1588	2325	27	3H-5CT	-21	44	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		28864	2325	27	3H-5CT	-21	44	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		43	2325	27	3H-5CT	-21	44	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL157138	2325	27	3H-5CT	-21	44	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB00589	2325	27	3H-5CT	-21	44	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		2105	3054	37	3H-5CT	-11	33	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		47811	3054	37	3H-5CT	-11	33	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		48	3054	37	3H-5CT	-11	33	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		CHEMBL531	3054	37	3H-5CT	-11	33	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		DB01186	3054	37	3H-5CT	-11	33	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		2470	3653	50	3H-5HT	-389	59	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-5HT	-389	59	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-5HT	-389	59	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-5HT	-389	59	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-5HT	-389	59	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		145	140	49	125I-LSD	-4	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		1832	140	49	125I-LSD	-4	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL7257	140	49	125I-LSD	-4	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB14010	140	49	125I-LSD	-4	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		206	2493	16	3H-5HT	-6	25	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		68848	2493	16	3H-5HT	-6	25	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		CHEMBL12314	2493	16	3H-5HT	-6	25	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		145	140	49	125I-LSD	-4	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		1832	140	49	125I-LSD	-4	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL7257	140	49	125I-LSD	-4	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB14010	140	49	125I-LSD	-4	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		25137849	216179	0	3H-LSD	-1	40	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
		71290	216179	0	3H-LSD	-1	40	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
		1524	2181	96	125I-LSD	-169	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	125I-LSD	-169	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	125I-LSD	-169	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	125I-LSD	-169	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	125I-LSD	-169	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	125I-LSD	-169	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		135398745	2914	112	3H-5-CT	-95	65	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-5-CT	-95	65	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-5-CT	-95	65	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-5-CT	-95	65	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		135398745	2914	112	3H-LSD	-95	65	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-LSD	-95	65	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-LSD	-95	65	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-LSD	-95	65	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		2726	919	68	3H-LSD	-13	72	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		2726	919	68	3H-LSD	-13	72	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-LSD	-13	72	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-LSD	-13	72	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-LSD	-13	72	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-LSD	-13	72	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-LSD	-13	72	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-LSD	-13	72	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-LSD	-13	72	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-LSD	-13	72	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		135398737	958	93	3H-LSD	-13	89	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135398737	958	93	3H-5HT	-9	89	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-LSD	-13	89	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-5HT	-9	89	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-LSD	-13	89	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-5HT	-9	89	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-LSD	-13	89	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-5HT	-9	89	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-LSD	-13	89	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-5HT	-9	89	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		206	2493	16	3H-5HT	-6	25	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		68848	2493	16	3H-5HT	-6	25	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		CHEMBL12314	2493	16	3H-5HT	-6	25	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		10257	738	31	3H-5CT	-13	19	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
		144	738	31	3H-5CT	-13	19	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
		CHEMBL416526	738	31	3H-5CT	-13	19	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
		DB01445	738	31	3H-5CT	-13	19	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
		3294	2006	111	3H-LSD	-21	45	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	2006	111	3H-LSD	-21	45	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	2006	111	3H-LSD	-21	45	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	2006	111	3H-LSD	-21	45	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	2006	111	3H-LSD	-21	45	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		5074	3332	80	125I-LSD	-36	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		97	3332	80	125I-LSD	-36	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		CHEMBL267777	3332	80	125I-LSD	-36	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		DB12693	3332	80	125I-LSD	-36	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		5074	3332	80	125I-LSD	-36	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		97	3332	80	125I-LSD	-36	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		CHEMBL267777	3332	80	125I-LSD	-36	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		DB12693	3332	80	125I-LSD	-36	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		2470	3653	50	3H-5CT	-3019	59	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-5CT	-3019	59	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-5CT	-3019	59	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-5CT	-3019	59	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-5CT	-3019	59	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		25107650	187285	0	UNDEFINED	-23	3	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	407	10	1	3	4.8	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	None
		CHEMBL492872	187285	0	UNDEFINED	-23	3	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	407	10	1	3	4.8	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	None
		62865	1274	0	3H-5HT	-7	14	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		746	1274	0	3H-5HT	-7	14	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		84	1274	0	3H-5HT	-7	14	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		CHEMBL2104153	1274	0	3H-5HT	-7	14	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		DB09000	1274	0	3H-5HT	-7	14	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		163839	2955	0	3H-LSD	-1	7	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	391	6	1	4	3.7	Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2	None
		268	2955	0	3H-LSD	-1	7	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	391	6	1	4	3.7	Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2	None
		CHEMBL55171	2955	0	3H-LSD	-1	7	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	391	6	1	4	3.7	Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2	None
		25107649	187257	0	UNDEFINED	-1	3	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	411	10	1	4	4.4	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	None
		CHEMBL492691	187257	0	UNDEFINED	-1	3	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	411	10	1	4	4.4	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	None
		134	2514	24	3H-5CT	-37	67	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-5CT	-37	67	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-5CT	-37	67	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-5CT	-37	67	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-5CT	-37	67	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		209	3057	97	3H-LSD	-31	23	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		2113	3057	97	3H-LSD	-31	23	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4748	3057	97	3H-LSD	-31	23	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL567	3057	97	3H-LSD	-31	23	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00850	3057	97	3H-LSD	-31	23	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		25107519	187669	0	UNDEFINED	-17	3	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	10	1	4	3.7	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	None
		CHEMBL495120	187669	0	UNDEFINED	-17	3	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	10	1	4	3.7	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	None
		202	1508	77	3H-5HT	-1	30	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		60835	1508	77	3H-5HT	-1	30	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		972	1508	77	3H-5HT	-1	30	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		CHEMBL1175	1508	77	3H-5HT	-1	30	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		DB00476	1508	77	3H-5HT	-1	30	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		209	3057	97	3H-LSD	-31	23	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		209	3057	97	3H-LSD	-25	23	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		2113	3057	97	3H-LSD	-31	23	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		2113	3057	97	3H-LSD	-25	23	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4748	3057	97	3H-LSD	-31	23	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4748	3057	97	3H-LSD	-25	23	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL567	3057	97	3H-LSD	-31	23	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL567	3057	97	3H-LSD	-25	23	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00850	3057	97	3H-LSD	-31	23	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00850	3057	97	3H-LSD	-25	23	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		25137849	216179	0	3H-LSD	-1	40	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
		71290	216179	0	3H-LSD	-1	40	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
		115	3791	80	3H-5HT	-8	27	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		4296	3791	80	3H-5HT	-8	27	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		CHEMBL274866	3791	80	3H-5HT	-8	27	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		1353	1911	93	3H-LSD	-120	83	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-LSD	-120	83	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-LSD	-120	83	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-LSD	-120	83	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-LSD	-120	83	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1346	83	117	125I-LSD	-147	9	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	None
		280	83	117	125I-LSD	-147	9	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	None
		9899402	83	117	125I-LSD	-147	9	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	None
		CHEMBL9666	83	117	125I-LSD	-147	9	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	None
		135398745	2914	112	3H-LSD	-95	65	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-LSD	-95	65	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-LSD	-95	65	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-LSD	-95	65	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		5	139	72	3H-5HT	-5	54	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-5HT	-5	54	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-5HT	-5	54	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-5HT	-5	54	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		206	2493	16	3H-5HT	-16	25	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		68848	2493	16	3H-5HT	-16	25	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		CHEMBL12314	2493	16	3H-5HT	-16	25	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		209	3057	97	3H-LSD	-25	23	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		2113	3057	97	3H-LSD	-25	23	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4748	3057	97	3H-LSD	-25	23	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL567	3057	97	3H-LSD	-25	23	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00850	3057	97	3H-LSD	-25	23	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		5074	3332	80	3H-MESULERGINE	-36	30	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		97	3332	80	3H-MESULERGINE	-36	30	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		CHEMBL267777	3332	80	3H-MESULERGINE	-36	30	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		DB12693	3332	80	3H-MESULERGINE	-36	30	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		2543	3707	68	3H-MESULERGINE	-44	32	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		5358	3707	68	3H-MESULERGINE	-44	32	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		54	3707	68	3H-MESULERGINE	-44	32	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL128	3707	68	3H-MESULERGINE	-44	32	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB00669	3707	68	3H-MESULERGINE	-44	32	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		24768520	93007	0	UNDEFINED	-1	4	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	434	9	2	4	4.6	CNc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
		CHEMBL244161	93007	0	UNDEFINED	-1	4	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	434	9	2	4	4.6	CNc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
		135398745	2914	112	3H-LSD	-95	65	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-LSD	-95	65	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-LSD	-95	65	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-LSD	-95	65	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		2176	3127	68	3H-5HT	-6165	27	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		4828	3127	68	3H-5HT	-6165	27	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		91	3127	68	3H-5HT	-6165	27	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		CHEMBL500	3127	68	3H-5HT	-6165	27	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		DB00960	3127	68	3H-5HT	-6165	27	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		2543	3707	68	3H-5HT	-44	32	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		5358	3707	68	3H-5HT	-44	32	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		54	3707	68	3H-5HT	-44	32	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL128	3707	68	3H-5HT	-44	32	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB00669	3707	68	3H-5HT	-44	32	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		1220	187	55	3H-5HT	-199	44	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	187	55	3H-5HT	-199	44	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	187	55	3H-5HT	-199	44	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	187	55	3H-5HT	-199	44	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		2543	3707	68	3H-5HT	-44	32	Guinea pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		5358	3707	68	3H-5HT	-44	32	Guinea pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		54	3707	68	3H-5HT	-44	32	Guinea pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL128	3707	68	3H-5HT	-44	32	Guinea pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB00669	3707	68	3H-5HT	-44	32	Guinea pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		1220	187	55	3H-5CT	-208	44	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	187	55	3H-5CT	-208	44	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	187	55	3H-5CT	-208	44	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	187	55	3H-5CT	-208	44	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7153	98020	77	UNDEFINED	-14	34	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	98020	77	UNDEFINED	-14	34	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		7153	98020	77	3H-5HT	-14	34	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	98020	77	3H-5HT	-14	34	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		265	128	0	3H-5CT	-4	3	Guinea pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	266	5	2	2	3.2	NCCc1c[nH]c2c1cc(OCc1ccccc1)cc2	None
		89576	128	0	3H-5CT	-4	3	Guinea pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	266	5	2	2	3.2	NCCc1c[nH]c2c1cc(OCc1ccccc1)cc2	None
		CHEMBL1288652	128	0	3H-5CT	-4	3	Guinea pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	266	5	2	2	3.2	NCCc1c[nH]c2c1cc(OCc1ccccc1)cc2	None
		1353	1911	93	3H-LSD	-120	83	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-LSD	-120	83	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-LSD	-120	83	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-LSD	-120	83	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-LSD	-120	83	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1353	1911	93	3H-LSD	-120	83	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-LSD	-120	83	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-LSD	-120	83	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-LSD	-120	83	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-LSD	-120	83	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1524	2181	96	3H-5HT	-169	52	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	3H-5HT	-169	52	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	3H-5HT	-169	52	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	3H-5HT	-169	52	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	3H-5HT	-169	52	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	3H-5HT	-169	52	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		1816	2540	102	3H-5HT	-165	18	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		4205	2540	102	3H-5HT	-165	18	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		7241	2540	102	3H-5HT	-165	18	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		CHEMBL654	2540	102	3H-5HT	-165	18	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		DB00370	2540	102	3H-5HT	-165	18	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		1830	2590	44	3H-LSD	-46	28	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		207	2590	44	3H-LSD	-46	28	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		23897	2590	44	3H-LSD	-46	28	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		CHEMBL460	2590	44	3H-LSD	-46	28	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		DB01618	2590	44	3H-LSD	-46	28	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		2726	919	68	3H-LSD	-13	72	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-LSD	-13	72	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-LSD	-13	72	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-LSD	-13	72	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-LSD	-13	72	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		None	216325	0	3H-LSD	-3	40	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	149	2	1	2	1.2	CC(C(=O)C1=CC=CC=C1)N	None
		15897	2862	0	3H-LSD	-12	36	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		215	2862	0	3H-LSD	-12	36	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		CHEMBL1979333	2862	0	3H-LSD	-12	36	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		24768525	143921	0	UNDEFINED	-7	3	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	406	8	1	4	4.0	O=C(CCCCCN1CCN(c2ccccn2)CC1)NC1CCCc2ccccc21	None
		CHEMBL390213	143921	0	UNDEFINED	-7	3	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	406	8	1	4	4.0	O=C(CCCCCN1CCN(c2ccccn2)CC1)NC1CCCc2ccccc21	None
		2435	3590	83	3H-LSD	-36	48	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		2435	3590	83	3H-5HT	-54	48	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		2435	3590	83	3H-LSD	-54	48	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		60149	3590	83	3H-LSD	-36	48	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		60149	3590	83	3H-5HT	-54	48	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		60149	3590	83	3H-LSD	-54	48	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		98	3590	83	3H-LSD	-36	48	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		98	3590	83	3H-5HT	-54	48	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		98	3590	83	3H-LSD	-54	48	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		CHEMBL12713	3590	83	3H-LSD	-36	48	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		CHEMBL12713	3590	83	3H-5HT	-54	48	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		CHEMBL12713	3590	83	3H-LSD	-54	48	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		DB06144	3590	83	3H-LSD	-36	48	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		DB06144	3590	83	3H-5HT	-54	48	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		DB06144	3590	83	3H-LSD	-54	48	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		16106	118146	34	3H-LSD	-3	12	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	291	0	0	3	2.9	CN1CCN(C2=Nc3ccccc3Cc3ccccc32)CC1	None
		CHEMBL340801	118146	34	3H-LSD	-3	12	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	291	0	0	3	2.9	CN1CCN(C2=Nc3ccccc3Cc3ccccc32)CC1	None
		2435	3590	83	3H-LSD	-36	48	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		60149	3590	83	3H-LSD	-36	48	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		98	3590	83	3H-LSD	-36	48	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		CHEMBL12713	3590	83	3H-LSD	-36	48	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		DB06144	3590	83	3H-LSD	-36	48	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		24768518	92839	0	UNDEFINED	-46	3	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	461	11	1	3	5.9	CCCCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
		CHEMBL243743	92839	0	UNDEFINED	-46	3	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	461	11	1	3	5.9	CCCCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
		102	4127	48	3H-5HT	-851	49	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	4127	48	3H-5HT	-851	49	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	4127	48	3H-5HT	-851	49	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	4127	48	3H-5HT	-851	49	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	4127	48	3H-5HT	-851	49	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		214	3860	58	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2740	3860	58	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5566	3860	58	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		66064	3860	58	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL422	3860	58	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00831	3860	58	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		1524	2181	96	3H-5CT	-1023	52	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	3H-5CT	-1023	52	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	3H-5CT	-1023	52	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	3H-5CT	-1023	52	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	3H-5CT	-1023	52	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	3H-5CT	-1023	52	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		2337	3256	77	3H-5HT	-32	62	Mouse	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	3H-5HT	-32	62	Mouse	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	3H-5HT	-32	62	Mouse	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	3H-5HT	-32	62	Mouse	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	3H-5HT	-32	62	Mouse	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		214	3860	58	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2740	3860	58	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5566	3860	58	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		66064	3860	58	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL422	3860	58	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00831	3860	58	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		25107717	187550	1	UNDEFINED	-6	3	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	420	10	1	5	3.6	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	None
		CHEMBL494512	187550	1	UNDEFINED	-6	3	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	420	10	1	5	3.6	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	None
		2389	3331	118	3H-LSD	-8	67	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-LSD	-8	67	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-LSD	-8	67	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-LSD	-8	67	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-LSD	-8	67	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		2389	3331	118	3H-LSD	-8	67	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-LSD	-8	67	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-LSD	-8	67	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-LSD	-8	67	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-LSD	-8	67	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		4106	2502	22	3H-5CT	-4	34	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		5358812	2502	22	3H-5CT	-4	34	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		89	2502	22	3H-5CT	-4	34	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		CHEMBL93240	2502	22	3H-5CT	-4	34	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		2389	3331	118	3H-LSD	-8	67	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-LSD	-8	67	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-LSD	-8	67	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-LSD	-8	67	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-LSD	-8	67	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		4106	2502	22	3H-5HT	-4	34	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		5358812	2502	22	3H-5HT	-4	34	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		89	2502	22	3H-5HT	-4	34	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		CHEMBL93240	2502	22	3H-5HT	-4	34	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		4106	2502	22	3H-5CT	-30	34	Guinea pig	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		4106	2502	22	3H-5HT	-4	34	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		5358812	2502	22	3H-5CT	-30	34	Guinea pig	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		5358812	2502	22	3H-5HT	-4	34	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		89	2502	22	3H-5CT	-30	34	Guinea pig	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		89	2502	22	3H-5HT	-4	34	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		CHEMBL93240	2502	22	3H-5CT	-30	34	Guinea pig	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		CHEMBL93240	2502	22	3H-5HT	-4	34	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		None	216278	0	3H-LSD	-42	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	426	6	0	6	3.4	C1CCC2C(C1)C(=O)N(C2=O)CCCCN3CCN(CC3)C4=NSC5=CC=CC=C54	None
		25107648	187223	0	UNDEFINED	25	3	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	467	8	0	3	5.6	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCc2ccccc2C1	None
		CHEMBL492480	187223	0	UNDEFINED	25	3	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	467	8	0	3	5.6	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCc2ccccc2C1	None
		145	140	49	3H-LSD	-2	30	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		1832	140	49	3H-LSD	-2	30	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL7257	140	49	3H-LSD	-2	30	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB14010	140	49	3H-LSD	-2	30	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		277	1301	62	3H-LSD	-63	50	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	1301	62	3H-LSD	-63	50	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	1301	62	3H-LSD	-63	50	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	1301	62	3H-LSD	-63	50	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	1301	62	3H-LSD	-63	50	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		134	2514	24	3H-LSD	-24	67	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-LSD	-24	67	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-LSD	-24	67	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-LSD	-24	67	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-LSD	-24	67	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		2435	3590	83	3H-LSD	-36	48	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		60149	3590	83	3H-LSD	-36	48	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		98	3590	83	3H-LSD	-36	48	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		CHEMBL12713	3590	83	3H-LSD	-36	48	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		DB06144	3590	83	3H-LSD	-36	48	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		None	215943	0	3H-5CT	-17	11	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(CC)C(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C	None
		1577	3703	110	3H-5HT	-213	21	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		2537	3703	110	3H-5HT	-213	21	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		5355	3703	110	3H-5HT	-213	21	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		5501	3703	110	3H-5HT	-213	21	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		643497	3703	110	3H-5HT	-213	21	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		688272	3703	110	3H-5HT	-213	21	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		958	3703	110	3H-5HT	-213	21	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		960	3703	110	3H-5HT	-213	21	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL196677	3703	110	3H-5HT	-213	21	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL26	3703	110	3H-5HT	-213	21	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL267044	3703	110	3H-5HT	-213	21	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		DB00391	3703	110	3H-5HT	-213	21	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		DB16021	3703	110	3H-5HT	-213	21	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		1830	2590	44	3H-LSD	-30	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		207	2590	44	3H-LSD	-30	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		23897	2590	44	3H-LSD	-30	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		CHEMBL460	2590	44	3H-LSD	-30	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		DB01618	2590	44	3H-LSD	-30	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		173	3262	95	3H-LSD	-34	23	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		5011	3262	95	3H-LSD	-34	23	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		CHEMBL18772	3262	95	3H-LSD	-34	23	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		1830	2590	44	3H-LSD	-30	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		207	2590	44	3H-LSD	-30	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		23897	2590	44	3H-LSD	-30	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		CHEMBL460	2590	44	3H-LSD	-30	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		DB01618	2590	44	3H-LSD	-30	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		2337	3256	77	3H-LSD	-28	62	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	3H-LSD	-28	62	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	3H-LSD	-28	62	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	3H-LSD	-28	62	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	3H-LSD	-28	62	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		2337	3256	77	3H-LSD	-28	62	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	3H-LSD	-28	62	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	3H-LSD	-28	62	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	3H-LSD	-28	62	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	3H-LSD	-28	62	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		2337	3256	77	3H-LSD	-28	62	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	3H-LSD	-28	62	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	3H-LSD	-28	62	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	3H-LSD	-28	62	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	3H-LSD	-28	62	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		2337	3256	77	3H-LSD	-28	62	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	3H-LSD	-28	62	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	3H-LSD	-28	62	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	3H-LSD	-28	62	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	3H-LSD	-28	62	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		25107517	187256	0	UNDEFINED	-1	3	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	421	8	0	4	4.0	COc1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	None
		CHEMBL492690	187256	0	UNDEFINED	-1	3	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	421	8	0	4	4.0	COc1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	None
		37459	746	13	3H-5HT	-74	25	Mouse	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		62	746	13	3H-5HT	-74	25	Mouse	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		CHEMBL8514	746	13	3H-5HT	-74	25	Mouse	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		206	2493	16	3H-5CT	-10	25	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		68848	2493	16	3H-5CT	-10	25	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		CHEMBL12314	2493	16	3H-5CT	-10	25	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		133	2496	52	3H-5HT	-36	42	Mouse	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	2496	52	3H-5HT	-36	42	Mouse	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	2496	52	3H-5HT	-36	42	Mouse	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	2496	52	3H-5HT	-36	42	Mouse	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	2496	52	3H-5HT	-36	42	Mouse	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		282	1419	0	3H-5HT	-3548	7	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	577	5	3	6	2.5	CC(CC1C(=O)N2CCCC2C2(N1C(=O)C(O2)(NC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
		522609	1419	0	3H-5HT	-3548	7	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	577	5	3	6	2.5	CC(CC1C(=O)N2CCCC2C2(N1C(=O)C(O2)(NC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
		135398745	2914	112	3H-5CT	-95	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-5CT	-95	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-5CT	-95	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-5CT	-95	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		None	216450	0	3H-5CT	-208	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
		None	216450	0	UNDEFINED	-208	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
		5074	3332	80	125I-LSD	-36	30	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		97	3332	80	125I-LSD	-36	30	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		CHEMBL267777	3332	80	125I-LSD	-36	30	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		DB12693	3332	80	125I-LSD	-36	30	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		1238	203174	24	3H-5CT	-13	16	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
		CHEMBL64249	203174	24	3H-5CT	-13	16	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
		1150	3878	121	125I-LSD	1	25	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		125	3878	121	125I-LSD	1	25	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		CHEMBL6640	3878	121	125I-LSD	1	25	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		DB08653	3878	121	125I-LSD	1	25	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		25107515	187360	0	UNDEFINED	-16	3	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	437	8	0	4	4.7	CSc1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	None
		CHEMBL493305	187360	0	UNDEFINED	-16	3	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	437	8	0	4	4.7	CSc1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	None
		1353	1911	93	3H-LSD	-263	83	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-LSD	-263	83	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-LSD	-263	83	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-LSD	-263	83	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-LSD	-263	83	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		5074	3332	80	125I-LSD	-36	30	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		97	3332	80	125I-LSD	-36	30	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		CHEMBL267777	3332	80	125I-LSD	-36	30	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		DB12693	3332	80	125I-LSD	-36	30	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		1150	3878	121	125I-LSD	1	25	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		125	3878	121	125I-LSD	1	25	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		CHEMBL6640	3878	121	125I-LSD	1	25	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		DB08653	3878	121	125I-LSD	1	25	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		1342	35	49	125I-LSD	-13	19	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		3	35	49	125I-LSD	-13	19	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		CHEMBL277120	35	49	125I-LSD	-13	19	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		1342	35	49	125I-LSD	-13	19	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		3	35	49	125I-LSD	-13	19	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		CHEMBL277120	35	49	125I-LSD	-13	19	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		277	1301	62	3H-5HT	-43	50	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	1301	62	3H-5HT	-43	50	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	1301	62	3H-5HT	-43	50	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	1301	62	3H-5HT	-43	50	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	1301	62	3H-5HT	-43	50	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		1353	1911	93	3H-5CT	-3801	83	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-5CT	-3801	83	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-5CT	-3801	83	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-5CT	-3801	83	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-5CT	-3801	83	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		24768522	142576	0	UNDEFINED	2	3	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	462	9	2	4	4.5	CC(=O)Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
		CHEMBL389110	142576	0	UNDEFINED	2	3	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	462	9	2	4	4.5	CC(=O)Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
		277	1301	62	3H-5HT	-43	50	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	1301	62	3H-5HT	-43	50	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	1301	62	3H-5HT	-43	50	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	1301	62	3H-5HT	-43	50	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	1301	62	3H-5HT	-43	50	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		1220	187	55	3H-5HT	-75	44	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	187	55	3H-5HT	-75	44	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	187	55	3H-5HT	-75	44	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	187	55	3H-5HT	-75	44	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		25107651	187710	0	UNDEFINED	-4	3	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	412	10	1	5	3.8	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	None
		CHEMBL495321	187710	0	UNDEFINED	-4	3	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	412	10	1	5	3.8	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	None
		1220	187	55	3H-5HT	-75	44	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	187	55	3H-5HT	-75	44	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	187	55	3H-5HT	-75	44	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	187	55	3H-5HT	-75	44	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		179	400	115	3H-LSD	-9	49	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		2159	400	115	3H-LSD	-9	49	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		963	400	115	3H-LSD	-9	49	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		CHEMBL243712	400	115	3H-LSD	-9	49	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		DB06288	400	115	3H-LSD	-9	49	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		166535	215970	0	3H-5HT	-87	2	Mouse	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	413	6	1	4	3.4	C1CN(CCC12C(=O)NCN2C3=CC=C(C=C3)F)CCCC(=O)C4=CC=C(C=C4)F	None
		1220	187	55	125I-LSD	-75	44	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	187	55	125I-LSD	-75	44	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	187	55	125I-LSD	-75	44	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	187	55	125I-LSD	-75	44	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		1220	187	55	125I-LSD	-75	44	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	187	55	125I-LSD	-75	44	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	187	55	125I-LSD	-75	44	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	187	55	125I-LSD	-75	44	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		2726	919	68	3H-LSD	-13	72	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-LSD	-13	72	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-LSD	-13	72	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-LSD	-13	72	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-LSD	-13	72	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		2726	919	68	3H-LSD	-13	72	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-LSD	-13	72	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-LSD	-13	72	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-LSD	-13	72	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-LSD	-13	72	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		7153	98020	77	125I-LSD	-14	34	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	98020	77	125I-LSD	-14	34	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		135	2532	43	3H-5HT	-50	58	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-5HT	-50	58	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-5HT	-50	58	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-5HT	-50	58	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-5HT	-50	58	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		54477	84653	36	3H-LSD	-501	23	Human	4.4	pKi	=	4.4	Binding	NoneNone	PDSP KiDatabase	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	None
		CHEMBL22242	84653	36	3H-LSD	-501	23	Human	4.4	pKi	=	4.4	Binding	NoneNone	PDSP KiDatabase	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	None
		135398745	2914	112	3H-5HT	-95	65	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-5HT	-95	65	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-5HT	-95	65	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-5HT	-95	65	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		135	2532	43	3H-5HT	-50	58	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-5HT	-50	58	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-5HT	-50	58	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-5HT	-50	58	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-5HT	-50	58	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		2477	745	59	125I-LSD	-21	29	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		36	745	59	125I-LSD	-21	29	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		437	745	59	125I-LSD	-21	29	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		CHEMBL49	745	59	125I-LSD	-21	29	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		DB00490	745	59	125I-LSD	-21	29	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		1353	1911	93	3H-LSD	-263	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-LSD	-263	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-LSD	-263	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-LSD	-263	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-LSD	-263	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1353	1911	93	3H-LSD	-263	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-LSD	-263	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-LSD	-263	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-LSD	-263	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-LSD	-263	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		242	470	124	3H-LSD	-15	51	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	470	124	3H-LSD	-15	51	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	470	124	3H-LSD	-15	51	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	470	124	3H-LSD	-15	51	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	470	124	3H-LSD	-15	51	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		1353	1911	93	3H-5HT	-74	83	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-5HT	-74	83	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-5HT	-74	83	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-5HT	-74	83	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-5HT	-74	83	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		2477	745	59	3H-5HT	-21	29	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		36	745	59	3H-5HT	-21	29	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		437	745	59	3H-5HT	-21	29	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		CHEMBL49	745	59	3H-5HT	-21	29	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		DB00490	745	59	3H-5HT	-21	29	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		1220	187	55	3H-5-HT	-208	44	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	187	55	3H-5-HT	-208	44	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	187	55	3H-5-HT	-208	44	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	187	55	3H-5-HT	-208	44	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		25107652	187412	0	UNDEFINED	-20	3	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	396	10	1	5	3.1	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	None
		CHEMBL493709	187412	0	UNDEFINED	-20	3	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	396	10	1	5	3.1	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	None
		242	470	124	3H-LSD	-15	51	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	470	124	3H-LSD	-15	51	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	470	124	3H-LSD	-15	51	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	470	124	3H-LSD	-15	51	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	470	124	3H-LSD	-15	51	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		135398737	958	93	3H-5HT	-7	89	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-5HT	-7	89	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-5HT	-7	89	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-5HT	-7	89	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-5HT	-7	89	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		191	403	98	3H-LSD	-19	29	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		201	403	98	3H-LSD	-19	29	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		2170	403	98	3H-LSD	-19	29	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		CHEMBL1113	403	98	3H-LSD	-19	29	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		DB00543	403	98	3H-LSD	-19	29	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		135398737	958	93	3H-5HT	-9	89	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135398737	958	93	3H-5HT	-7	89	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-5HT	-9	89	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-5HT	-7	89	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-5HT	-9	89	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-5HT	-7	89	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-5HT	-9	89	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-5HT	-7	89	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-5HT	-9	89	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-5HT	-7	89	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		1613	2348	53	3H-LSD	-14	44	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	2348	53	3H-LSD	-14	44	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	2348	53	3H-LSD	-14	44	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	2348	53	3H-LSD	-14	44	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	2348	53	3H-LSD	-14	44	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		134	2514	24	3H-5HT	-37	67	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-5HT	-37	67	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-5HT	-37	67	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-5HT	-37	67	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-5HT	-37	67	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		134	2514	24	3H-5HT	-18	67	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-5HT	-18	67	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-5HT	-18	67	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-5HT	-18	67	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-5HT	-18	67	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		2389	3331	118	3H-5HT	-8	67	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-5HT	-8	67	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-5HT	-8	67	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-5HT	-8	67	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-5HT	-8	67	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		16351	102730	47	3H-LSD	-1	6	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	None
		CHEMBL304902	102730	47	3H-LSD	-1	6	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	None
		279	1661	26	3H-LSD	1	18	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	None
		49381	1661	26	3H-LSD	1	18	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	None
		CHEMBL63756	1661	26	3H-LSD	1	18	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	None
		2865	4143	73	3H-LSD	-12	53	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	3H-LSD	-12	53	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	3H-LSD	-12	53	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	3H-LSD	-12	53	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	3H-LSD	-12	53	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		2105	3054	37	125I-LSD	-5	33	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		47811	3054	37	125I-LSD	-5	33	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		48	3054	37	125I-LSD	-5	33	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		CHEMBL531	3054	37	125I-LSD	-5	33	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		DB01186	3054	37	125I-LSD	-5	33	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		5	139	72	125I-LSD	-5	54	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	125I-LSD	-5	54	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	125I-LSD	-5	54	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	125I-LSD	-5	54	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		2865	4143	73	3H-5HT	-10	53	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	3H-5HT	-10	53	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	3H-5HT	-10	53	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	3H-5HT	-10	53	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	3H-5HT	-10	53	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		135398737	958	93	3H-LSD	-13	89	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-LSD	-13	89	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-LSD	-13	89	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-LSD	-13	89	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-LSD	-13	89	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		191	403	98	3H-LSD	-19	29	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		201	403	98	3H-LSD	-19	29	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		2170	403	98	3H-LSD	-19	29	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		CHEMBL1113	403	98	3H-LSD	-19	29	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		DB00543	403	98	3H-LSD	-19	29	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		1220	187	55	3H-5CT	-51	44	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	187	55	3H-5CT	-51	44	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	187	55	3H-5CT	-51	44	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	187	55	3H-5CT	-51	44	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		1353	1911	93	3H-5-CT	-263	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-5-CT	-263	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-5-CT	-263	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-5-CT	-263	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-5-CT	-263	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		2601	3780	33	3H-5CT	-20	21	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		443951	3780	33	3H-5CT	-20	21	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		56	3780	33	3H-5CT	-20	21	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL73151	3780	33	3H-5CT	-20	21	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB13399	3780	33	3H-5CT	-20	21	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		15897	2862	0	3H-LSD	-12	36	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		215	2862	0	3H-LSD	-12	36	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		CHEMBL1979333	2862	0	3H-LSD	-12	36	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		3337	206367	27	3H-LSD	-169	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	206367	27	3H-LSD	-169	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	206367	27	3H-LSD	-169	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	206367	27	3H-LSD	-169	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	206367	27	3H-LSD	-169	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		25108474	193200	0	UNDEFINED	-38	3	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	423	8	0	4	4.6	CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	None
		CHEMBL523381	193200	0	UNDEFINED	-38	3	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	423	8	0	4	4.6	CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	None
		135398737	958	93	3H-LSD	-13	89	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-LSD	-13	89	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-LSD	-13	89	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-LSD	-13	89	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-LSD	-13	89	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		24768523	143680	0	UNDEFINED	-4	2	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	498	10	2	5	3.9	CS(=O)(=O)Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
		CHEMBL390015	143680	0	UNDEFINED	-4	2	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	498	10	2	5	3.9	CS(=O)(=O)Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
		1613	2348	53	3H-LSD	-14	44	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	2348	53	3H-LSD	-14	44	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	2348	53	3H-LSD	-14	44	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	2348	53	3H-LSD	-14	44	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	2348	53	3H-LSD	-14	44	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		242	470	124	3H-5-CT	-15	51	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	470	124	3H-5-CT	-15	51	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	470	124	3H-5-CT	-15	51	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	470	124	3H-5-CT	-15	51	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	470	124	3H-5-CT	-15	51	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		5074	3332	80	3H-5HT	-69	30	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		97	3332	80	3H-5HT	-69	30	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		CHEMBL267777	3332	80	3H-5HT	-69	30	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		DB12693	3332	80	3H-5HT	-69	30	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		5074	3332	80	3H-5HT	-69	30	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		97	3332	80	3H-5HT	-69	30	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		CHEMBL267777	3332	80	3H-5HT	-69	30	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		DB12693	3332	80	3H-5HT	-69	30	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		4106	2502	22	3H-5CT	-30	34	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		5358812	2502	22	3H-5CT	-30	34	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		89	2502	22	3H-5CT	-30	34	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		CHEMBL93240	2502	22	3H-5CT	-30	34	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		5074	3332	80	3H-5CT	-61	30	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		97	3332	80	3H-5CT	-61	30	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		CHEMBL267777	3332	80	3H-5CT	-61	30	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		DB12693	3332	80	3H-5CT	-61	30	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		1220	187	55	3H-5HT	-208	44	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	187	55	3H-5HT	-208	44	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	187	55	3H-5HT	-208	44	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	187	55	3H-5HT	-208	44	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		1220	187	55	3H-5HT	-208	44	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	187	55	3H-5HT	-208	44	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	187	55	3H-5HT	-208	44	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	187	55	3H-5HT	-208	44	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		135398737	958	93	3H-5CT	-34	89	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-5CT	-34	89	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-5CT	-34	89	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-5CT	-34	89	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-5CT	-34	89	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		277	1301	62	125I-LSD	-43	50	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	1301	62	125I-LSD	-43	50	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	1301	62	125I-LSD	-43	50	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	1301	62	125I-LSD	-43	50	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	1301	62	125I-LSD	-43	50	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2470	3653	50	3H-5CT	-3019	59	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-5CT	-3019	59	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-5CT	-3019	59	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-5CT	-3019	59	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-5CT	-3019	59	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		135398737	958	93	3H-5HT	-13	89	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-5HT	-13	89	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-5HT	-13	89	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-5HT	-13	89	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-5HT	-13	89	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		277	1301	62	125I-LSD	-43	50	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	1301	62	125I-LSD	-43	50	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	1301	62	125I-LSD	-43	50	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	1301	62	125I-LSD	-43	50	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	1301	62	125I-LSD	-43	50	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		31101	729	40	3H-5HT	-25	36	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		35	729	40	3H-5HT	-25	36	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		403	729	40	3H-5HT	-25	36	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		CHEMBL493	729	40	3H-5HT	-25	36	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		DB01200	729	40	3H-5HT	-25	36	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		31101	729	40	3H-5HT	-25	36	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		35	729	40	3H-5HT	-25	36	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		403	729	40	3H-5HT	-25	36	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		CHEMBL493	729	40	3H-5HT	-25	36	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		DB01200	729	40	3H-5HT	-25	36	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		133	2496	52	3H-5CT	-15	42	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	2496	52	3H-5CT	-15	42	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	2496	52	3H-5CT	-15	42	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	2496	52	3H-5CT	-15	42	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	2496	52	3H-5CT	-15	42	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		11954224	215953	0	3H-5CT	-1174	58	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		18971832	2418	0	3H-5HT	-812	13	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	None
		21	2418	0	3H-5HT	-812	13	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	None
		CHEMBL3186179	2418	0	3H-5HT	-812	13	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	None
		24768517	92828	0	UNDEFINED	2	3	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	447	10	1	3	5.5	CCCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
		CHEMBL243742	92828	0	UNDEFINED	2	3	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	447	10	1	3	5.5	CCCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
		5	139	72	125I-LSD	-5	54	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	125I-LSD	-5	54	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	125I-LSD	-5	54	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	125I-LSD	-5	54	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		107	141	121	3H-5HT	-3	30	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	141	121	3H-5HT	-3	30	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	141	121	3H-5HT	-3	30	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		2865	4143	73	3H-5-CT	-12	53	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	3H-5-CT	-12	53	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	3H-5-CT	-12	53	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	3H-5-CT	-12	53	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	3H-5-CT	-12	53	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		5	139	72	3H-5HT	-11	54	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-5HT	-11	54	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-5HT	-11	54	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-5HT	-11	54	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		107	141	121	3H-5HT	-3	30	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	141	121	3H-5HT	-3	30	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	141	121	3H-5HT	-3	30	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		11976	920	59	3H-LSD	-5	24	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		667467	920	59	3H-LSD	-5	24	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		CHEMBL908	920	59	3H-LSD	-5	24	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		DB01239	920	59	3H-LSD	-5	24	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		2389	3331	118	3H-5CT	-8	67	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		2389	3331	118	3H-MESULERGINE	-7	67	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-5CT	-8	67	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-MESULERGINE	-7	67	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-5CT	-8	67	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-MESULERGINE	-7	67	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-5CT	-8	67	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-MESULERGINE	-7	67	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-5CT	-8	67	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-MESULERGINE	-7	67	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5074	3332	80	3H-MESULERGINE	-61	30	Guinea pig	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		97	3332	80	3H-MESULERGINE	-61	30	Guinea pig	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		CHEMBL267777	3332	80	3H-MESULERGINE	-61	30	Guinea pig	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		DB12693	3332	80	3H-MESULERGINE	-61	30	Guinea pig	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		25107578	193056	0	UNDEFINED	4	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	408	10	1	4	4.2	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	None
		CHEMBL522343	193056	0	UNDEFINED	4	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	408	10	1	4	4.2	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	None
		216239	23795	118	None	-9	7	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counter	Drug Central	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	None
		CHEMBL1200485	23795	118	None	-9	7	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counter	Drug Central	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	None
		CHEMBL1336	23795	118	None	-9	7	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counter	Drug Central	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	None
		66265	94013	15	None	-1	19	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCN[C@@H](C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL248702	94013	15	None	-1	19	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCN[C@@H](C)Cc1cccc(C(F)(F)F)c1	None
		2726	919	68	None	-301	72	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	None	-301	72	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	None	-301	72	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	None	-301	72	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	None	-301	72	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		122	1437	9	3H-5CT	-1	11	Guinea pig	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
		156314	1437	9	3H-5CT	-1	11	Guinea pig	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL1332062	1437	9	3H-5CT	-1	11	Guinea pig	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4223	3992	94	None	-81	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
		6918314	3992	94	None	-81	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
		7427	3992	94	None	-81	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
		CHEMBL439849	3992	94	None	-81	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
		DB06684	3992	94	None	-81	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
		102	4127	48	None	-851	49	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	4127	48	None	-851	49	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	4127	48	None	-851	49	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	4127	48	None	-851	49	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	4127	48	None	-851	49	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		11976	920	59	3H-LSD	-5	24	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		667467	920	59	3H-LSD	-5	24	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		CHEMBL908	920	59	3H-LSD	-5	24	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		DB01239	920	59	3H-LSD	-5	24	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		11976	920	59	3H-LSD	-5	24	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		667467	920	59	3H-LSD	-5	24	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		CHEMBL908	920	59	3H-LSD	-5	24	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		DB01239	920	59	3H-LSD	-5	24	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		25107718	187538	0	UNDEFINED	18	3	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	535	12	1	6	4.7	CS(=O)(=O)Oc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1	None
		CHEMBL494458	187538	0	UNDEFINED	18	3	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	535	12	1	6	4.7	CS(=O)(=O)Oc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1	None
		240	944	43	None	-19	24	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		2769	944	43	None	-19	24	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		44279790	944	43	None	-19	24	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		660	944	43	None	-19	24	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		CHEMBL1729	944	43	None	-19	24	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		CHEMBL560739	944	43	None	-19	24	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		DB00604	944	43	None	-19	24	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		2402	3370	62	None	-6	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		5095	3370	62	None	-6	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		7295	3370	62	None	-6	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		CHEMBL589	3370	62	None	-6	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		DB00268	3370	62	None	-6	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		103	4153	61	3H-LSD	-6	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	4153	61	3H-LSD	-6	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	4153	61	3H-LSD	-6	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	4153	61	3H-LSD	-6	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	4153	61	3H-LSD	-6	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		1220	187	55	3H-5HT	-51	44	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	187	55	3H-5HT	-51	44	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	187	55	3H-5HT	-51	44	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	187	55	3H-5HT	-51	44	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		11954224	215953	0	3H-5HT	-269	58	Mouse	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		6450478	216012	0	3H-LSD	-1	12	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	340	0	0	6	3.4	CN1CCN(CC1)C2=NC3=CSC=C3C(=CC#N)C4=CSC=C42	None
		1353	1911	93	3H-5HT	-120	83	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-5HT	-120	83	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-5HT	-120	83	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-5HT	-120	83	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-5HT	-120	83	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3033769	3281	61	3H-LSD	-1380	19	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		3299	3281	61	3H-LSD	-1380	19	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		94	3281	61	3H-LSD	-1380	19	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		CHEMBL8809	3281	61	3H-LSD	-1380	19	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		DB12518	3281	61	3H-LSD	-1380	19	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		1577	3703	110	3H-LSD	-213	21	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		2537	3703	110	3H-LSD	-213	21	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		5355	3703	110	3H-LSD	-213	21	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		5501	3703	110	3H-LSD	-213	21	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		643497	3703	110	3H-LSD	-213	21	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		688272	3703	110	3H-LSD	-213	21	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		958	3703	110	3H-LSD	-213	21	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		960	3703	110	3H-LSD	-213	21	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL196677	3703	110	3H-LSD	-213	21	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL26	3703	110	3H-LSD	-213	21	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL267044	3703	110	3H-LSD	-213	21	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		DB00391	3703	110	3H-LSD	-213	21	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		DB16021	3703	110	3H-LSD	-213	21	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		54477	84653	36	3H-LSD	-69	23	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	None
		CHEMBL22242	84653	36	3H-LSD	-69	23	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	None
		53389	98447	23	3H-LSD	-1	6	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	3.9	C[C@H]1CN(CCCn2c3ccccc3c3ccccc32)C[C@@H](C)N1	None
		CHEMBL275707	98447	23	3H-LSD	-1	6	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	3.9	C[C@H]1CN(CCCn2c3ccccc3c3ccccc32)C[C@@H](C)N1	None
		33630	178957	99	3H-LSD	-891	28	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
		CHEMBL47050	178957	99	3H-LSD	-891	28	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
		None	215987	0	3H-LSD	-1	2	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	342	1	1	5	1.8	CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2O)C=C(C=C4)Cl	None
		None	215988	0	3H-LSD	-1	2	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	334	4	0	3	4.9	C[N+](C)(CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl)[O-]	None
		277	1301	62	3H-5CT	-301	50	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	1301	62	3H-5CT	-301	50	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	1301	62	3H-5CT	-301	50	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	1301	62	3H-5CT	-301	50	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	1301	62	3H-5CT	-301	50	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2176	3127	68	3H-MESULERGINE	-1584	27	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		4828	3127	68	3H-MESULERGINE	-1584	27	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		91	3127	68	3H-MESULERGINE	-1584	27	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		CHEMBL500	3127	68	3H-MESULERGINE	-1584	27	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		DB00960	3127	68	3H-MESULERGINE	-1584	27	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		2726	919	68	3H-5HT	-301	72	Mouse	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-5HT	-301	72	Mouse	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-5HT	-301	72	Mouse	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-5HT	-301	72	Mouse	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-5HT	-301	72	Mouse	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		1577	3703	110	3H-LSD	-275	21	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		2537	3703	110	3H-LSD	-275	21	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		5355	3703	110	3H-LSD	-275	21	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		5501	3703	110	3H-LSD	-275	21	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		643497	3703	110	3H-LSD	-275	21	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		688272	3703	110	3H-LSD	-275	21	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		958	3703	110	3H-LSD	-275	21	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		960	3703	110	3H-LSD	-275	21	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL196677	3703	110	3H-LSD	-275	21	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL26	3703	110	3H-LSD	-275	21	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL267044	3703	110	3H-LSD	-275	21	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		DB00391	3703	110	3H-LSD	-275	21	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		DB16021	3703	110	3H-LSD	-275	21	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		2543	3707	68	3H-5HT	-93	32	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		2543	3707	68	3H-5HT	-44	32	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		5358	3707	68	3H-5HT	-93	32	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		5358	3707	68	3H-5HT	-44	32	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		54	3707	68	3H-5HT	-93	32	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		54	3707	68	3H-5HT	-44	32	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL128	3707	68	3H-5HT	-93	32	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL128	3707	68	3H-5HT	-44	32	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB00669	3707	68	3H-5HT	-93	32	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB00669	3707	68	3H-5HT	-44	32	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		1220	187	55	3H-5HT	-208	44	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		1220	187	55	3H-5HT	-75	44	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	187	55	3H-5HT	-208	44	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	187	55	3H-5HT	-75	44	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	187	55	3H-5HT	-208	44	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	187	55	3H-5HT	-75	44	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	187	55	3H-5HT	-208	44	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	187	55	3H-5HT	-75	44	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		1220	187	55	UNDEFINED	-75	44	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	187	55	UNDEFINED	-75	44	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	187	55	UNDEFINED	-75	44	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	187	55	UNDEFINED	-75	44	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		283	3130	57	3H-5CT	-28	12	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
		4847	3130	57	3H-5CT	-28	12	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
		CHEMBL18331	3130	57	3H-5CT	-28	12	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
		None	216052	0	3H-5CT	-67	8	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	339	4	3	3	1.9	CCC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C	None
		1220	187	55	125I-LSD	-75	44	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	187	55	125I-LSD	-75	44	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	187	55	125I-LSD	-75	44	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	187	55	125I-LSD	-75	44	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		1342	35	49	125I-LSD	-13	19	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		3	35	49	125I-LSD	-13	19	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		CHEMBL277120	35	49	125I-LSD	-13	19	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		115	3791	80	125I-LSD	-8	27	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		4296	3791	80	125I-LSD	-8	27	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		CHEMBL274866	3791	80	125I-LSD	-8	27	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		24768519	92863	0	UNDEFINED	1	3	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	461	8	1	3	5.9	CC(C)(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
		CHEMBL243953	92863	0	UNDEFINED	1	3	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	461	8	1	3	5.9	CC(C)(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
		25108475	187485	0	UNDEFINED	-2	3	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	419	8	0	3	5.0	CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	None
		CHEMBL494119	187485	0	UNDEFINED	-2	3	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	419	8	0	3	5.0	CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	None
		681	1465	72	125I-LSD	-354	39	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	1465	72	125I-LSD	-354	39	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	1465	72	125I-LSD	-354	39	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	1465	72	125I-LSD	-354	39	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	1465	72	125I-LSD	-354	39	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		484	2858	51	125I-LSD	-1	35	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		951	2858	51	125I-LSD	-1	35	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		CHEMBL432	2858	51	125I-LSD	-1	35	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		2176	3127	68	125I-LSD	-6165	27	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		4828	3127	68	125I-LSD	-6165	27	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		91	3127	68	125I-LSD	-6165	27	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		CHEMBL500	3127	68	125I-LSD	-6165	27	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		DB00960	3127	68	125I-LSD	-6165	27	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		2543	3707	68	125I-LSD	-44	32	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		5358	3707	68	125I-LSD	-44	32	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		54	3707	68	125I-LSD	-44	32	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL128	3707	68	125I-LSD	-44	32	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB00669	3707	68	125I-LSD	-44	32	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		108182	4131	22	125I-LSD	-2	16	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
		245	4131	22	125I-LSD	-2	16	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
		CHEMBL18041	4131	22	125I-LSD	-2	16	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
		73333	5963	31	3H-LSD	-35	9	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	401	7	1	2	4.2	CCNC(=O)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
		CHEMBL1079935	5963	31	3H-LSD	-35	9	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	401	7	1	2	4.2	CCNC(=O)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
		73333	5963	31	3H-LSD	-35	9	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	401	7	1	2	4.2	CCNC(=O)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
		CHEMBL1079935	5963	31	3H-LSD	-35	9	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	401	7	1	2	4.2	CCNC(=O)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
		135	2532	43	3H-5HT	-83	58	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-5HT	-83	58	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-5HT	-83	58	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-5HT	-83	58	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-5HT	-83	58	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		2543	3707	68	125I-LSD	-44	32	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		5358	3707	68	125I-LSD	-44	32	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		54	3707	68	125I-LSD	-44	32	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL128	3707	68	125I-LSD	-44	32	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB00669	3707	68	125I-LSD	-44	32	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		15387	45822	55	3H-LSD	-85	24	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		CHEMBL1531134	45822	55	3H-LSD	-85	24	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		15387	45822	55	3H-LSD	-85	24	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		CHEMBL1531134	45822	55	3H-LSD	-85	24	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		10624	70300	19	3H-LSD	-46	33	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		138543650	70300	19	3H-LSD	-46	33	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		CHEMBL194378	70300	19	3H-LSD	-46	33	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		2543	3707	68	None	-93	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		5358	3707	68	None	-93	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		54	3707	68	None	-93	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL128	3707	68	None	-93	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB00669	3707	68	None	-93	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		5	139	72	3H- LSD	-3	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H- LSD	-3	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H- LSD	-3	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H- LSD	-3	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		2865	4143	73	3H-LSD	-12	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	3H-LSD	-12	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	3H-LSD	-12	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	3H-LSD	-12	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	3H-LSD	-12	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		25107516	187185	0	UNDEFINED	-4	3	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	433	8	0	3	5.1	CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	None
		CHEMBL492282	187185	0	UNDEFINED	-4	3	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	433	8	0	3	5.1	CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	None
		133	2496	52	3H-5HT	-16	42	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	2496	52	3H-5HT	-16	42	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	2496	52	3H-5HT	-16	42	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	2496	52	3H-5HT	-16	42	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	2496	52	3H-5HT	-16	42	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		133	2496	52	3H-5HT	-16	42	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	2496	52	3H-5HT	-16	42	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	2496	52	3H-5HT	-16	42	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	2496	52	3H-5HT	-16	42	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	2496	52	3H-5HT	-16	42	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		191	403	98	None	-41	29	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		201	403	98	None	-41	29	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		2170	403	98	None	-41	29	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		CHEMBL1113	403	98	None	-41	29	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		DB00543	403	98	None	-41	29	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		1353	1911	93	None	-74	83	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	None	-74	83	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	None	-74	83	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	None	-74	83	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	None	-74	83	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		107	141	121	3H-5HT	-9	30	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	141	121	3H-5HT	-9	30	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	141	121	3H-5HT	-9	30	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		135398737	958	93	3H-LSD	-7	89	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-LSD	-7	89	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-LSD	-7	89	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-LSD	-7	89	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-LSD	-7	89	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		1588	2325	27	3H-5HT	-6	44	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		1588	2325	27	UNDEFINED	-6	44	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		28864	2325	27	3H-5HT	-6	44	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		28864	2325	27	UNDEFINED	-6	44	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		43	2325	27	3H-5HT	-6	44	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		43	2325	27	UNDEFINED	-6	44	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL157138	2325	27	3H-5HT	-6	44	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL157138	2325	27	UNDEFINED	-6	44	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB00589	2325	27	3H-5HT	-6	44	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB00589	2325	27	UNDEFINED	-6	44	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		4106	2502	22	3H-5HT	-15	34	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		5358812	2502	22	3H-5HT	-15	34	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		89	2502	22	3H-5HT	-15	34	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		CHEMBL93240	2502	22	3H-5HT	-15	34	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		5	139	72	3H-5CT	-3	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-5CT	-3	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-5CT	-3	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-5CT	-3	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		206	2493	16	3H-LSD	-6	25	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		68848	2493	16	3H-LSD	-6	25	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		CHEMBL12314	2493	16	3H-LSD	-6	25	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		180	401	56	None	-12	40	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		180	401	56	None	-99	40	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		200	401	56	None	-12	40	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		200	401	56	None	-99	40	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2160	401	56	None	-12	40	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2160	401	56	None	-99	40	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL629	401	56	None	-12	40	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL629	401	56	None	-99	40	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		DB00321	401	56	None	-12	40	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		DB00321	401	56	None	-99	40	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2477	745	59	None	-7	29	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		2477	745	59	None	-21	29	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		36	745	59	None	-7	29	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		36	745	59	None	-21	29	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		437	745	59	None	-7	29	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		437	745	59	None	-21	29	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		CHEMBL49	745	59	None	-7	29	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		CHEMBL49	745	59	None	-21	29	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		DB00490	745	59	None	-7	29	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		DB00490	745	59	None	-21	29	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		1524	2181	96	None	-38	52	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	None	-38	52	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	None	-38	52	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	None	-38	52	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	None	-38	52	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	None	-38	52	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		133	2496	52	3H-5HT	-10	42	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	2496	52	3H-5HT	-10	42	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	2496	52	3H-5HT	-10	42	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	2496	52	3H-5HT	-10	42	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	2496	52	3H-5HT	-10	42	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1353	1911	93	None	-263	83	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	None	-263	83	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	None	-263	83	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	None	-263	83	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	None	-263	83	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		133	2496	52	3H-5HT	-10	42	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	2496	52	3H-5HT	-10	42	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	2496	52	3H-5HT	-10	42	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	2496	52	3H-5HT	-10	42	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	2496	52	3H-5HT	-10	42	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1524	2181	96	None	-501	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	None	-501	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	None	-501	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	None	-501	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	None	-501	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	None	-501	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		114948	60297	14	None	1	3	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	577	5	3	6	2.5	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	None
		CHEMBL1743263	60297	14	None	1	3	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	577	5	3	6	2.5	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	None
		2337	3256	77	None	-28	62	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	None	-28	62	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	None	-28	62	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	None	-28	62	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	None	-28	62	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		214	3860	58	None	-52	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2740	3860	58	None	-52	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5566	3860	58	None	-52	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		66064	3860	58	None	-52	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL422	3860	58	None	-52	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00831	3860	58	None	-52	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		1830	2590	44	None	-30	28	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		207	2590	44	None	-30	28	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		23897	2590	44	None	-30	28	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		CHEMBL460	2590	44	None	-30	28	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		DB01618	2590	44	None	-30	28	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		1353	1911	93	None	-120	83	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	None	-120	83	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	None	-120	83	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	None	-120	83	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	None	-120	83	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1816	2540	102	None	-165	18	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		4205	2540	102	None	-165	18	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		7241	2540	102	None	-165	18	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		CHEMBL654	2540	102	None	-165	18	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		DB00370	2540	102	None	-165	18	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		2543	3707	68	None	-44	32	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		5358	3707	68	None	-44	32	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		54	3707	68	None	-44	32	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL128	3707	68	None	-44	32	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB00669	3707	68	None	-44	32	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		1621	2429	17	3H-LSD	-34	45	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		17	2429	17	3H-LSD	-34	45	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		5761	2429	17	3H-LSD	-34	45	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL263881	2429	17	3H-LSD	-34	45	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB04829	2429	17	3H-LSD	-34	45	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		2389	3331	118	3H-LSD	-8	67	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-LSD	-8	67	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-LSD	-8	67	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-LSD	-8	67	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-LSD	-8	67	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		6971132	216009	0	3H-LSD	-1	14	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	268	1	2	2	2.1	CN1CC(C=C2C1CC3=CNC4=CC=CC2=C34)C(=O)O	None
		2865	4143	73	3H-LSD	-12	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	3H-LSD	-12	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	3H-LSD	-12	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	3H-LSD	-12	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	3H-LSD	-12	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		2865	4143	73	3H-LSD	-12	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	3H-LSD	-12	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	3H-LSD	-12	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	3H-LSD	-12	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	3H-LSD	-12	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		1524	2181	96	None	-169	52	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	None	-169	52	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	None	-169	52	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	None	-169	52	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	None	-169	52	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	None	-169	52	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		4806	4008	88	None	1	13	Rat	8.2	pKi	=	8.2	Binding	antagonistantagonist	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
		7351	4008	88	None	1	13	Rat	8.2	pKi	=	8.2	Binding	antagonistantagonist	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
		9966051	4008	88	None	1	13	Rat	8.2	pKi	=	8.2	Binding	antagonistantagonist	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
		CHEMBL2104993	4008	88	None	1	13	Rat	8.2	pKi	=	8.2	Binding	antagonistantagonist	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
		DB09068	4008	88	None	1	13	Rat	8.2	pKi	=	8.2	Binding	antagonistantagonist	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
		228	445	28	None	-6	24	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		33	445	28	None	-6	24	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		6005	445	28	None	-6	24	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		CHEMBL53	445	28	None	-6	24	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		DB00714	445	28	None	-6	24	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		10531	1420	21	None	-87	23	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		121	1420	21	None	-87	23	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		888	1420	21	None	-87	23	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		CHEMBL1732	1420	21	None	-87	23	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		DB00320	1420	21	None	-87	23	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		1588	2325	27	3H-LSD	-19	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		28864	2325	27	3H-LSD	-19	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		43	2325	27	3H-LSD	-19	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL157138	2325	27	3H-LSD	-19	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB00589	2325	27	3H-LSD	-19	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		2895	203592	41	None	-1	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	None
		CHEMBL669	203592	41	None	-1	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	None
		277	1301	62	None	-63	50	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	1301	62	None	-63	50	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	1301	62	None	-63	50	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	1301	62	None	-63	50	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	1301	62	None	-63	50	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		3652	4097	79	None	-6	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		57	4097	79	None	-6	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		60809	4097	79	None	-6	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		CHEMBL21536	4097	79	None	-6	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		DB15357	4097	79	None	-6	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		133	2496	52	3H-5CT	-15	42	Guinea pig	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	2496	52	3H-5CT	-15	42	Guinea pig	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	2496	52	3H-5CT	-15	42	Guinea pig	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	2496	52	3H-5CT	-15	42	Guinea pig	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	2496	52	3H-5CT	-15	42	Guinea pig	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		2389	3331	118	3H-LSD	-8	67	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-LSD	-8	67	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-LSD	-8	67	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-LSD	-8	67	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-LSD	-8	67	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		11154555	800	62	None	-117	12	Human	8.2	pKi	=	8.2	Binding	CHO cells, [3H]LSD (1.5nM)CHO cells, [3H]LSD (1.5nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		5037	800	62	None	-117	12	Human	8.2	pKi	=	8.2	Binding	CHO cells, [3H]LSD (1.5nM)CHO cells, [3H]LSD (1.5nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		7671	800	62	None	-117	12	Human	8.2	pKi	=	8.2	Binding	CHO cells, [3H]LSD (1.5nM)CHO cells, [3H]LSD (1.5nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL2028019	800	62	None	-117	12	Human	8.2	pKi	=	8.2	Binding	CHO cells, [3H]LSD (1.5nM)CHO cells, [3H]LSD (1.5nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL3085826	800	62	None	-117	12	Human	8.2	pKi	=	8.2	Binding	CHO cells, [3H]LSD (1.5nM)CHO cells, [3H]LSD (1.5nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB06016	800	62	None	-117	12	Human	8.2	pKi	=	8.2	Binding	CHO cells, [3H]LSD (1.5nM)CHO cells, [3H]LSD (1.5nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		2470	3653	50	None	-1258	59	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	None	-1258	59	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	None	-1258	59	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	None	-1258	59	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	None	-1258	59	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		135398745	2914	112	None	-95	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	None	-95	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	None	-95	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	None	-95	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		135409468	2035	69	3H-LSD	-21	39	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		333	2035	69	3H-LSD	-21	39	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		CHEMBL845	2035	69	3H-LSD	-21	39	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		135398737	958	93	3H-5HT	-13	89	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135398737	958	93	3H-5HT	-7	89	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-5HT	-13	89	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-5HT	-7	89	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-5HT	-13	89	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-5HT	-7	89	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-5HT	-13	89	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-5HT	-7	89	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-5HT	-13	89	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-5HT	-7	89	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135398737	958	93	UNDEFINED	-7	89	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	UNDEFINED	-7	89	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	UNDEFINED	-7	89	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	UNDEFINED	-7	89	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	UNDEFINED	-7	89	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		133	2496	52	3H-5HT	-16	42	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	2496	52	3H-5HT	-16	42	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	2496	52	3H-5HT	-16	42	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	2496	52	3H-5HT	-16	42	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	2496	52	3H-5HT	-16	42	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		2470	3653	50	3H-5HT	-1096	59	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-5HT	-1096	59	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-5HT	-1096	59	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-5HT	-1096	59	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-5HT	-1096	59	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5567	42802	27	3H-LSD	-69	8	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	409	6	1	3	4.8	O=C(CCCN1CCC(O)(c2cccc(C(F)(F)F)c2)CC1)c1ccc(F)cc1	None
		CHEMBL15023	42802	27	3H-LSD	-69	8	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	409	6	1	3	4.8	O=C(CCCN1CCC(O)(c2cccc(C(F)(F)F)c2)CC1)c1ccc(F)cc1	None
		133	2496	52	UNDEFINED	-16	42	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	2496	52	UNDEFINED	-16	42	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	2496	52	UNDEFINED	-16	42	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	2496	52	UNDEFINED	-16	42	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	2496	52	UNDEFINED	-16	42	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		2470	3653	50	3H-5HT	-1096	59	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-5HT	-1096	59	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-5HT	-1096	59	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-5HT	-1096	59	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-5HT	-1096	59	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		135398737	958	93	3H-5CT	-13	89	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-5CT	-13	89	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-5CT	-13	89	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-5CT	-13	89	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-5CT	-13	89	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		100	3805	58	3H-LSD	-18	55	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	3H-LSD	-18	55	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	3H-LSD	-18	55	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	3H-LSD	-18	55	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	3H-LSD	-18	55	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		107780	1844	54	3H-5CT	-2691	17	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		14	1844	54	3H-5CT	-2691	17	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		CHEMBL15928	1844	54	3H-5CT	-2691	17	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		1524	2181	96	3H-5CT	-1023	52	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	3H-5CT	-1023	52	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	3H-5CT	-1023	52	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	3H-5CT	-1023	52	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	3H-5CT	-1023	52	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	3H-5CT	-1023	52	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		1150	3878	121	3H-5CT	-1	25	Guinea pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		125	3878	121	3H-5CT	-1	25	Guinea pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		CHEMBL6640	3878	121	3H-5CT	-1	25	Guinea pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		DB08653	3878	121	3H-5CT	-1	25	Guinea pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		None	216239	0	3H-LSD	-64565	30	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	316	7	3	3	3.0	CC(CF)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O	None
		135398737	958	93	3H-LSD	-13	89	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-LSD	-13	89	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-LSD	-13	89	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-LSD	-13	89	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-LSD	-13	89	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		206	2493	16	3H-5CT	-15	25	Guinea pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		68848	2493	16	3H-5CT	-15	25	Guinea pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		CHEMBL12314	2493	16	3H-5CT	-15	25	Guinea pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		135398737	958	93	3H-LSD	-13	89	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-LSD	-13	89	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-LSD	-13	89	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-LSD	-13	89	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-LSD	-13	89	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135	2532	43	3H-5CT	-138	58	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-5CT	-138	58	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-5CT	-138	58	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-5CT	-138	58	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-5CT	-138	58	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		135	2532	43	3H-5HT	-50	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-5HT	-50	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-5HT	-50	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-5HT	-50	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-5HT	-50	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		135	2532	43	UNDEFINED	-50	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	UNDEFINED	-50	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	UNDEFINED	-50	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	UNDEFINED	-50	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	UNDEFINED	-50	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		2274	3173	58	3H-LSD	-3235	31	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4917	3173	58	3H-LSD	-3235	31	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		7279	3173	58	3H-LSD	-3235	31	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL728	3173	58	3H-LSD	-3235	31	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00433	3173	58	3H-LSD	-3235	31	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		180	401	56	None	-125	40	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		200	401	56	None	-125	40	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2160	401	56	None	-125	40	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL629	401	56	None	-125	40	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		DB00321	401	56	None	-125	40	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		135	2532	43	None	-21	58	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	None	-21	58	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	None	-21	58	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	None	-21	58	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	None	-21	58	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		135398745	2914	112	None	-34	65	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	None	-34	65	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	None	-34	65	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	None	-34	65	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		114948	60297	14	None	-1	3	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	577	5	3	6	2.5	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	None
		CHEMBL1743263	60297	14	None	-1	3	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	577	5	3	6	2.5	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	None
		135	2532	43	None	-83	58	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	None	-83	58	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	None	-83	58	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	None	-83	58	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	None	-83	58	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		206	2493	16	125I-LSD	-6	25	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		68848	2493	16	125I-LSD	-6	25	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		CHEMBL12314	2493	16	125I-LSD	-6	25	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		129211	3749	78	None	-151	15	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	Drug Central	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	None
		2562	3749	78	None	-151	15	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	Drug Central	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	None
		488	3749	78	None	-151	15	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	Drug Central	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	None
		CHEMBL836	3749	78	None	-151	15	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	Drug Central	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	None
		DB00706	3749	78	None	-151	15	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	Drug Central	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	None
		24768516	92586	0	UNDEFINED	11	3	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	433	9	1	3	5.1	CCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
		CHEMBL243523	92586	0	UNDEFINED	11	3	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	433	9	1	3	5.1	CCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
		206	2493	16	125I-LSD	-6	25	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		68848	2493	16	125I-LSD	-6	25	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		CHEMBL12314	2493	16	125I-LSD	-6	25	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		100	3805	58	None	-28	55	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	None	-28	55	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	None	-28	55	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	None	-28	55	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	None	-28	55	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		135	2532	43	None	-50	58	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	None	-50	58	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	None	-50	58	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	None	-50	58	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	None	-50	58	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		2470	3653	50	None	-1096	59	Mouse	8.1	pKi	=	8.1	Binding	Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	None	-1096	59	Mouse	8.1	pKi	=	8.1	Binding	Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	None	-1096	59	Mouse	8.1	pKi	=	8.1	Binding	Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	None	-1096	59	Mouse	8.1	pKi	=	8.1	Binding	Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	None	-1096	59	Mouse	8.1	pKi	=	8.1	Binding	Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		62865	1274	0	None	-7	14	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		746	1274	0	None	-7	14	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		84	1274	0	None	-7	14	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		CHEMBL2104153	1274	0	None	-7	14	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		DB09000	1274	0	None	-7	14	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		100	3805	58	None	-18	55	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	None	-18	55	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	None	-18	55	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	None	-18	55	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	None	-18	55	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		277	1301	62	None	-43	50	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	1301	62	None	-43	50	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	1301	62	None	-43	50	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	1301	62	None	-43	50	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	1301	62	None	-43	50	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		11954224	215953	0	None	-269	58	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		1613	2348	53	None	-14	44	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	2348	53	None	-14	44	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	2348	53	None	-14	44	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	2348	53	None	-14	44	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	2348	53	None	-14	44	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		191	403	98	None	-19	29	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		201	403	98	None	-19	29	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		2170	403	98	None	-19	29	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		CHEMBL1113	403	98	None	-19	29	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		DB00543	403	98	None	-19	29	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		135398737	958	93	None	-9	89	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	None	-9	89	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	None	-9	89	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	None	-9	89	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	None	-9	89	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		2726	919	68	None	-13	72	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	None	-13	72	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	None	-13	72	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	None	-13	72	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	None	-13	72	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		49831411	217746	0	None	-1	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	659	19	0	6	8.7	CCCCCCCCCCCC(=O)OCN1C(=O)CCC2=CC=C(OCCCCN3CCN(CC3)C3=C(Cl)C(Cl)=CC=C3)C=C12	None
		133	2496	52	None	-36	42	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	2496	52	None	-36	42	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	2496	52	None	-36	42	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	2496	52	None	-36	42	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	2496	52	None	-36	42	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		2435	3590	83	None	-36	48	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		60149	3590	83	None	-36	48	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		98	3590	83	None	-36	48	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		CHEMBL12713	3590	83	None	-36	48	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		DB06144	3590	83	None	-36	48	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		2220	3134	82	None	-3	14	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	Drug Central	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
		27400	3134	82	None	-3	14	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	Drug Central	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
		93	3134	82	None	-3	14	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	Drug Central	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
		CHEMBL294951	3134	82	None	-3	14	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	Drug Central	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
		DB06153	3134	82	None	-3	14	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	Drug Central	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
		209	3057	97	None	-25	23	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		2113	3057	97	None	-25	23	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4748	3057	97	None	-25	23	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL567	3057	97	None	-25	23	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00850	3057	97	None	-25	23	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		209	3057	97	None	-31	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		2113	3057	97	None	-31	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4748	3057	97	None	-31	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL567	3057	97	None	-31	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00850	3057	97	None	-31	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		3294	2006	111	None	-41	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	2006	111	None	-41	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	2006	111	None	-41	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	2006	111	None	-41	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	2006	111	None	-41	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		2726	919	68	None	-13	72	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	None	-13	72	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	None	-13	72	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	None	-13	72	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	None	-13	72	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		242	470	124	None	-15	51	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	470	124	None	-15	51	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	470	124	None	-15	51	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	470	124	None	-15	51	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	470	124	None	-15	51	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		3294	2006	111	None	-21	45	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	2006	111	None	-21	45	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	2006	111	None	-21	45	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	2006	111	None	-21	45	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	2006	111	None	-21	45	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		4806	4008	88	None	-8	13	Human	8.1	pKi	=	8.1	Binding	antagonistantagonist	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
		7351	4008	88	None	-8	13	Human	8.1	pKi	=	8.1	Binding	antagonistantagonist	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
		9966051	4008	88	None	-8	13	Human	8.1	pKi	=	8.1	Binding	antagonistantagonist	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
		CHEMBL2104993	4008	88	None	-8	13	Human	8.1	pKi	=	8.1	Binding	antagonistantagonist	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
		DB09068	4008	88	None	-8	13	Human	8.1	pKi	=	8.1	Binding	antagonistantagonist	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
		135398737	958	93	None	-13	89	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	None	-13	89	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	None	-13	89	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	None	-13	89	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	None	-13	89	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		242	470	124	None	-14	51	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	470	124	None	-14	51	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	470	124	None	-14	51	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	470	124	None	-14	51	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	470	124	None	-14	51	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		134	2514	24	None	-24	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	None	-24	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	None	-24	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	None	-24	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	None	-24	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		49831411	217746	0	None	-1	15	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	659	19	0	6	8.7	CCCCCCCCCCCC(=O)OCN1C(=O)CCC2=CC=C(OCCCCN3CCN(CC3)C3=C(Cl)C(Cl)=CC=C3)C=C12	None
		3294	2006	111	3H-LSD	-41	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	2006	111	3H-LSD	-41	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	2006	111	3H-LSD	-41	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	2006	111	3H-LSD	-41	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	2006	111	3H-LSD	-41	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		212	3806	47	None	-7	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		2639	3806	47	None	-7	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		941651	3806	47	None	-7	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		CHEMBL1201	3806	47	None	-7	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		DB01623	3806	47	None	-7	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		134	2514	24	None	-18	67	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	None	-18	67	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	None	-18	67	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	None	-18	67	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	None	-18	67	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		134	2514	24	None	-9	67	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	None	-9	67	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	None	-9	67	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	None	-9	67	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	None	-9	67	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1212	1662	50	3H-LSD	-18	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		1212	1662	50	3H-LSD	-15	65	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	3H-LSD	-18	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	3H-LSD	-15	65	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	3H-LSD	-18	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	3H-LSD	-15	65	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	3H-LSD	-18	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	3H-LSD	-15	65	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	3H-LSD	-18	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	3H-LSD	-15	65	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		1621	2429	17	3H-MESULERGINE	-34	45	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		17	2429	17	3H-MESULERGINE	-34	45	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		5761	2429	17	3H-MESULERGINE	-34	45	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL263881	2429	17	3H-MESULERGINE	-34	45	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB04829	2429	17	3H-MESULERGINE	-34	45	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		2601	3780	33	3H-5CT	-20	21	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		443951	3780	33	3H-5CT	-20	21	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		56	3780	33	3H-5CT	-20	21	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL73151	3780	33	3H-5CT	-20	21	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB13399	3780	33	3H-5CT	-20	21	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		2726	919	68	3H-5HT	-13	72	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-5HT	-13	72	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-5HT	-13	72	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-5HT	-13	72	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-5HT	-13	72	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		100	3805	58	3H-LSD	-18	55	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	3H-LSD	-18	55	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	3H-LSD	-18	55	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	3H-LSD	-18	55	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	3H-LSD	-18	55	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2726	919	68	UNDEFINED	-13	72	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	UNDEFINED	-13	72	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	UNDEFINED	-13	72	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	UNDEFINED	-13	72	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	UNDEFINED	-13	72	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		162265	202274	22	3H-LSD	-16	43	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		4786	202274	22	3H-LSD	-16	43	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		CHEMBL61006	202274	22	3H-LSD	-16	43	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		None	216239	0	3H-LSD	-64565	30	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	316	7	3	3	3.0	CC(CF)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O	None
		25107583	192877	0	UNDEFINED	-2	3	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	489	12	1	7	3.0	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	None
		CHEMBL522194	192877	0	UNDEFINED	-2	3	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	489	12	1	7	3.0	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	None
		1712	2492	43	3H-LSD	-18	22	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		4078	2492	43	3H-LSD	-18	22	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		7227	2492	43	3H-LSD	-18	22	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		CHEMBL1088	2492	43	3H-LSD	-18	22	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		DB00933	2492	43	3H-LSD	-18	22	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		1712	2492	43	3H-LSD	-18	22	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		4078	2492	43	3H-LSD	-18	22	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		7227	2492	43	3H-LSD	-18	22	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		CHEMBL1088	2492	43	3H-LSD	-18	22	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		DB00933	2492	43	3H-LSD	-18	22	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		3337	206367	27	3H-LSD	-169	40	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	206367	27	3H-LSD	-169	40	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	206367	27	3H-LSD	-169	40	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	206367	27	3H-LSD	-169	40	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	206367	27	3H-LSD	-169	40	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		1524	2181	96	3H-5HT	-501	52	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		1524	2181	96	3H-5HT	-169	52	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	3H-5HT	-501	52	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	3H-5HT	-169	52	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	3H-5HT	-501	52	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	3H-5HT	-169	52	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	3H-5HT	-501	52	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	3H-5HT	-169	52	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	3H-5HT	-501	52	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	3H-5HT	-169	52	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	3H-5HT	-501	52	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	3H-5HT	-169	52	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		25107582	187584	0	UNDEFINED	-9	3	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	501	12	1	6	4.1	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	None
		CHEMBL494661	187584	0	UNDEFINED	-9	3	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	501	12	1	6	4.1	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	None
		277	1301	62	3H-5HT	-43	50	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	1301	62	3H-5HT	-43	50	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	1301	62	3H-5HT	-43	50	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	1301	62	3H-5HT	-43	50	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	1301	62	3H-5HT	-43	50	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		135398737	958	93	3H-LSD	-13	89	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-LSD	-13	89	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-LSD	-13	89	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-LSD	-13	89	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-LSD	-13	89	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		277	1301	62	UNDEFINED	-43	50	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	1301	62	UNDEFINED	-43	50	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	1301	62	UNDEFINED	-43	50	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	1301	62	UNDEFINED	-43	50	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	1301	62	UNDEFINED	-43	50	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		None	215971	0	125I-LSD	-616	15	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	473	7	0	5	3.5	COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O.Br	None
		None	215971	0	125I-LSD	-616	15	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	473	7	0	5	3.5	COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O.Br	None
		1524	2181	96	3H-5CT	-501	52	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	3H-5CT	-501	52	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	3H-5CT	-501	52	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	3H-5CT	-501	52	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	3H-5CT	-501	52	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	3H-5CT	-501	52	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		2470	3653	50	None	-389	59	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	None	-389	59	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	None	-389	59	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	None	-389	59	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	None	-389	59	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		31101	729	40	None	-25	36	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		35	729	40	None	-25	36	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		403	729	40	None	-25	36	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		CHEMBL493	729	40	None	-25	36	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		DB01200	729	40	None	-25	36	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		10531	1420	21	None	-23	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		121	1420	21	None	-23	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		888	1420	21	None	-23	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		CHEMBL1732	1420	21	None	-23	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		DB00320	1420	21	None	-23	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		1212	1662	50	3H-LSD	-18	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		1212	1662	50	3H-LSD	-15	65	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	3H-LSD	-18	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	3H-LSD	-15	65	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	3H-LSD	-18	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	3H-LSD	-15	65	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	3H-LSD	-18	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	3H-LSD	-15	65	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	3H-LSD	-18	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	3H-LSD	-15	65	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		1212	1662	50	None	-18	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		1212	1662	50	None	-15	65	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	None	-18	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	None	-15	65	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	None	-18	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	None	-15	65	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	None	-18	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	None	-15	65	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	None	-18	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	None	-15	65	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3389	217711	0	None	-1	26	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	549	12	0	6	6.8	CCCCCCC(=O)OCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1	None
		5	139	72	3H-5HT	-3	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-5HT	-3	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-5HT	-3	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-5HT	-3	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5	139	72	3H-5HT	-3	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-5HT	-3	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-5HT	-3	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-5HT	-3	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		133	2496	52	None	-16	42	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	2496	52	None	-16	42	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	2496	52	None	-16	42	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	2496	52	None	-16	42	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	2496	52	None	-16	42	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		135398737	958	93	None	-7	89	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	None	-7	89	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	None	-7	89	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	None	-7	89	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	None	-7	89	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		133	2496	52	None	-10	42	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	2496	52	None	-10	42	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	2496	52	None	-10	42	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	2496	52	None	-10	42	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	2496	52	None	-10	42	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		11976	920	59	None	-5	24	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		667467	920	59	None	-5	24	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		CHEMBL908	920	59	None	-5	24	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		DB01239	920	59	None	-5	24	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		145	140	49	3H-5HT	-4	30	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		1832	140	49	3H-5HT	-4	30	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL7257	140	49	3H-5HT	-4	30	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB14010	140	49	3H-5HT	-4	30	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		2865	4143	73	None	-12	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	None	-12	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	None	-12	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	None	-12	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	None	-12	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		25107647	187484	0	UNDEFINED	11	3	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	453	8	0	3	5.6	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1Cc2ccccc2C1	None
		CHEMBL494118	187484	0	UNDEFINED	11	3	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	453	8	0	3	5.6	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1Cc2ccccc2C1	None
		145	140	49	3H-5HT	-4	30	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		1832	140	49	3H-5HT	-4	30	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL7257	140	49	3H-5HT	-4	30	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB14010	140	49	3H-5HT	-4	30	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		103	4153	61	None	-6	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	4153	61	None	-6	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	4153	61	None	-6	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	4153	61	None	-6	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	4153	61	None	-6	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		11978813	721	79	None	-6	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		5014	721	79	None	-6	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		7672	721	79	None	-6	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		CHEMBL2105760	721	79	None	-6	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		DB09128	721	79	None	-6	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		2389	3331	118	None	-8	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	None	-8	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	None	-8	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	None	-8	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	None	-8	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		115237	55585	119	None	-20	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	55585	119	None	-20	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		25107580	187513	0	UNDEFINED	2	3	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	432	10	1	4	4.7	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	None
		CHEMBL494312	187513	0	UNDEFINED	2	3	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	432	10	1	4	4.7	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	None
		439280	120019	107	None	-1	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	None
		6971044	120019	107	None	-1	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	None
		CHEMBL350221	120019	107	None	-1	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	None
		1621	2429	17	None	-34	45	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		17	2429	17	None	-34	45	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		5761	2429	17	None	-34	45	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL263881	2429	17	None	-34	45	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB04829	2429	17	None	-34	45	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		103	4153	61	None	-2	53	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	4153	61	None	-2	53	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	4153	61	None	-2	53	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	4153	61	None	-2	53	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	4153	61	None	-2	53	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2389	3331	118	None	-7	67	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	None	-7	67	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	None	-7	67	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	None	-7	67	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	None	-7	67	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		214	3860	58	3H-LSD	-95	30	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2740	3860	58	3H-LSD	-95	30	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5566	3860	58	3H-LSD	-95	30	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		66064	3860	58	3H-LSD	-95	30	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL422	3860	58	3H-LSD	-95	30	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00831	3860	58	3H-LSD	-95	30	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		135	2532	43	3H-5HT	-83	58	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-5HT	-83	58	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-5HT	-83	58	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-5HT	-83	58	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-5HT	-83	58	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		24768526	93231	0	UNDEFINED	-41	2	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	422	8	1	4	3.2	O=C(CCCCCN1CCN(c2cccc[n+]2[O-])CC1)NC1CCCc2ccccc21	None
		CHEMBL244792	93231	0	UNDEFINED	-41	2	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	422	8	1	4	3.2	O=C(CCCCCN1CCN(c2cccc[n+]2[O-])CC1)NC1CCCc2ccccc21	None
		4452	2762	19	3H-LSD	-2754	19	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	None
		983	2762	19	3H-LSD	-2754	19	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	None
		CHEMBL20734	2762	19	3H-LSD	-2754	19	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	None
		24768521	93012	0	UNDEFINED	-19	2	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	420	8	2	4	4.1	Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
		CHEMBL244162	93012	0	UNDEFINED	-19	2	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	420	8	2	4	4.1	Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
		1342	35	49	3H-5HT	-33	19	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		3	35	49	3H-5HT	-33	19	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		CHEMBL277120	35	49	3H-5HT	-33	19	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		134	2514	24	3H-5HT	-24	67	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-5HT	-24	67	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-5HT	-24	67	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-5HT	-24	67	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-5HT	-24	67	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1342	35	49	3H-5HT	-33	19	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		3	35	49	3H-5HT	-33	19	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		CHEMBL277120	35	49	3H-5HT	-33	19	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		134	2514	24	3H-5HT	-24	67	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-5HT	-24	67	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-5HT	-24	67	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-5HT	-24	67	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-5HT	-24	67	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		2477	745	59	[3H]-5-carboxamidotryptamine	-128	29	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		36	745	59	[3H]-5-carboxamidotryptamine	-128	29	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		437	745	59	[3H]-5-carboxamidotryptamine	-128	29	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		CHEMBL49	745	59	[3H]-5-carboxamidotryptamine	-128	29	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		DB00490	745	59	[3H]-5-carboxamidotryptamine	-128	29	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		1613	2348	53	3H-LSD	-23	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	2348	53	3H-LSD	-23	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	2348	53	3H-LSD	-23	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	2348	53	3H-LSD	-23	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	2348	53	3H-LSD	-23	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		1613	2348	53	3H-LSD	-23	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	2348	53	3H-LSD	-23	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	2348	53	3H-LSD	-23	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	2348	53	3H-LSD	-23	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	2348	53	3H-LSD	-23	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		141	1427	35	3H-LSD	1	22	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		6089	1427	35	3H-LSD	1	22	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		CHEMBL12420	1427	35	3H-LSD	1	22	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		DB01488	1427	35	3H-LSD	1	22	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		6852400	215937	0	3H-5CT	-1023	22	Guinea pig	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		73759726	215937	0	3H-5CT	-1023	22	Guinea pig	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		1613	2348	53	3H-LSD	-23	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	2348	53	3H-LSD	-23	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	2348	53	3H-LSD	-23	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	2348	53	3H-LSD	-23	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	2348	53	3H-LSD	-23	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		37459	746	13	UNDEFINED	-194	25	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		62	746	13	UNDEFINED	-194	25	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		CHEMBL8514	746	13	UNDEFINED	-194	25	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		2105	3054	37	None	-5	33	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		47811	3054	37	None	-5	33	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		48	3054	37	None	-5	33	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		CHEMBL531	3054	37	None	-5	33	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		DB01186	3054	37	None	-5	33	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		25107579	187442	0	UNDEFINED	-1	3	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	436	10	1	5	4.3	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	None
		CHEMBL493909	187442	0	UNDEFINED	-1	3	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	436	10	1	5	4.3	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	None
		None	215938	0	3H-5HT	-151	21	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	583	4	3	6	2.1	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C	None
		None	215938	0	3H-5HT	-151	21	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	583	4	3	6	2.1	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C	None
		16362	3125	71	None	-5	30	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		2172	3125	71	None	-5	30	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		90	3125	71	None	-5	30	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		CHEMBL1423	3125	71	None	-5	30	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		DB01100	3125	71	None	-5	30	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		1588	2325	27	None	-6	44	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		28864	2325	27	None	-6	44	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		43	2325	27	None	-6	44	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL157138	2325	27	None	-6	44	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB00589	2325	27	None	-6	44	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		213046	2385	59	None	2	9	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	None
		4168	2385	59	None	2	9	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	None
		7461	2385	59	None	2	9	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	None
		CHEMBL1237021	2385	59	None	2	9	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	None
		DB08815	2385	59	None	2	9	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	None
		16362	3125	71	None	-11	30	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		2172	3125	71	None	-11	30	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		90	3125	71	None	-11	30	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		CHEMBL1423	3125	71	None	-11	30	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		DB01100	3125	71	None	-11	30	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		206	2493	16	125I-LSD	-6	25	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		68848	2493	16	125I-LSD	-6	25	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		CHEMBL12314	2493	16	125I-LSD	-6	25	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		2865	4143	73	3H-LSD	-12	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	3H-LSD	-12	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	3H-LSD	-12	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	3H-LSD	-12	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	3H-LSD	-12	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		206	2493	16	125I-LSD	-6	25	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		68848	2493	16	125I-LSD	-6	25	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		CHEMBL12314	2493	16	125I-LSD	-6	25	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		2865	4143	73	3H-LSD	-12	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	3H-LSD	-12	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	3H-LSD	-12	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	3H-LSD	-12	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	3H-LSD	-12	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		46780481	107531	20	None	-16	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		9903970	107531	20	None	-16	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3187365	107531	20	None	-16	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3544974	107531	20	None	-16	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		1621	2429	17	3H-5HT	-34	45	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		17	2429	17	3H-5HT	-34	45	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		5761	2429	17	3H-5HT	-34	45	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL263881	2429	17	3H-5HT	-34	45	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB04829	2429	17	3H-5HT	-34	45	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		103	4153	61	3H-LSD	-6	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	4153	61	3H-LSD	-6	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	4153	61	3H-LSD	-6	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	4153	61	3H-LSD	-6	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	4153	61	3H-LSD	-6	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		None	215943	0	3H-5HT	-7	11	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(CC)C(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C	None
		1621	2429	17	UNDEFINED	-34	45	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		17	2429	17	UNDEFINED	-34	45	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		5761	2429	17	UNDEFINED	-34	45	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL263881	2429	17	UNDEFINED	-34	45	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB04829	2429	17	UNDEFINED	-34	45	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		242	470	124	3H-LSD	-15	51	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	470	124	3H-LSD	-15	51	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	470	124	3H-LSD	-15	51	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	470	124	3H-LSD	-15	51	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	470	124	3H-LSD	-15	51	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		2470	3653	50	3H-LSD	-389	59	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-LSD	-389	59	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-LSD	-389	59	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-LSD	-389	59	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-LSD	-389	59	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		6852400	215937	0	3H-5HT	-223	22	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		73759726	215937	0	3H-5HT	-223	22	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		180	401	56	3H-5HT	-125	40	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		200	401	56	3H-5HT	-125	40	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2160	401	56	3H-5HT	-125	40	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL629	401	56	3H-5HT	-125	40	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		DB00321	401	56	3H-5HT	-125	40	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		134	2514	24	3H-5CT	-37	67	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-5CT	-37	67	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-5CT	-37	67	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-5CT	-37	67	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-5CT	-37	67	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1353	1911	93	3H-5CT	-3801	83	Guinea pig	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-5CT	-3801	83	Guinea pig	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-5CT	-3801	83	Guinea pig	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-5CT	-3801	83	Guinea pig	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-5CT	-3801	83	Guinea pig	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		10257	738	31	3H-5CT	-13	19	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
		144	738	31	3H-5CT	-13	19	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
		CHEMBL416526	738	31	3H-5CT	-13	19	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
		DB01445	738	31	3H-5CT	-13	19	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
		2543	3707	68	3H-5HT	-93	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		5358	3707	68	3H-5HT	-93	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		54	3707	68	3H-5HT	-93	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL128	3707	68	3H-5HT	-93	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB00669	3707	68	3H-5HT	-93	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		2543	3707	68	3H-5HT	-93	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		5358	3707	68	3H-5HT	-93	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		54	3707	68	3H-5HT	-93	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL128	3707	68	3H-5HT	-93	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB00669	3707	68	3H-5HT	-93	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		100	3805	58	3H-LSD	-28	55	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	3H-LSD	-28	55	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	3H-LSD	-28	55	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	3H-LSD	-28	55	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	3H-LSD	-28	55	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		4806	4008	88	None	-8	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	21486038
		7351	4008	88	None	-8	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	21486038
		9966051	4008	88	None	-8	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	21486038
		CHEMBL2104993	4008	88	None	-8	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	21486038
		DB09068	4008	88	None	-8	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	21486038
		281	3510	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	9720804
		5312148	3510	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	9720804
		CHEMBL12264	3510	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	9720804
		242	470	124	None	-14	51	Rat	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10327430
		34	470	124	None	-14	51	Rat	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10327430
		60795	470	124	None	-14	51	Rat	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10327430
		CHEMBL1112	470	124	None	-14	51	Rat	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10327430
		DB01238	470	124	None	-14	51	Rat	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10327430
		11959	1536	0	None	-2	4	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	405	5	1	7	3.0	Cn1c(=O)c(c(cn1)NCCN1CCC(CC1)c1noc2c1ccc(c2)F)Cl	22824189
		9909267	1536	0	None	-2	4	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	405	5	1	7	3.0	Cn1c(=O)c(c(cn1)NCCN1CCC(CC1)c1noc2c1ccc(c2)F)Cl	22824189
		11151899	2137	13	None	1	4	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	22570363
		8432	2137	13	None	1	4	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	22570363
		CHEMBL4205783	2137	13	None	1	4	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	22570363
		24825775	1523	14	None	346	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	19118950
		3929	1523	14	None	346	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	19118950
		CHEMBL4205349	1523	14	None	346	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	19118950
		8431	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10052959
		8431	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	12825922
		9843179	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10052959
		9843179	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	12825922
		CHEMBL69257	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10052959
		CHEMBL69257	1484	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	12825922
		10028436	3532	5	None	-1	12	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	12392747
		3237	3532	5	None	-1	12	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	12392747
		CHEMBL95104	3532	5	None	-1	12	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	12392747
		3233	3512	44	None	2	12	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10807680
		3247	3512	44	None	2	12	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10807680
		6604889	3512	44	None	2	12	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10807680
		CHEMBL282199	3512	44	None	2	12	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10807680
		DB13988	3512	44	None	2	12	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10807680
		5	139	72	None	-5	54	Rat	9.0	pKi	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8394362
		5	139	72	None	-5	54	Rat	9.0	pKi	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8397408
		5202	139	72	None	-5	54	Rat	9.0	pKi	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8394362
		5202	139	72	None	-5	54	Rat	9.0	pKi	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8397408
		CHEMBL39	139	72	None	-5	54	Rat	9.0	pKi	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8394362
		CHEMBL39	139	72	None	-5	54	Rat	9.0	pKi	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8397408
		DB08839	139	72	None	-5	54	Rat	9.0	pKi	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8394362
		DB08839	139	72	None	-5	54	Rat	9.0	pKi	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8397408
		23642275	482	31	None	60	3	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	23541835
		8433	482	31	None	60	3	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	23541835
		CHEMBL2164327	482	31	None	60	3	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	23541835
		25107716	2351	43	None	3	7	Rat	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	18800769
		8436	2351	43	None	3	7	Rat	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	18800769
		CHEMBL522691	2351	43	None	3	7	Rat	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	18800769
		16362	3125	71	None	-5	30	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	7908055
		2172	3125	71	None	-5	30	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	7908055
		90	3125	71	None	-5	30	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	7908055
		CHEMBL1423	3125	71	None	-5	30	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	7908055
		DB01100	3125	71	None	-5	30	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	7908055
		213046	2385	59	None	2	9	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	20404009
		4168	2385	59	None	2	9	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	20404009
		7461	2385	59	None	2	9	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	20404009
		CHEMBL1237021	2385	59	None	2	9	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	20404009
		DB08815	2385	59	None	2	9	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	20404009
		11224758	2353	5	None	-4	6	Human	9.7	pKi	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	17649988
		8435	2353	5	None	-4	6	Human	9.7	pKi	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	17649988
		CHEMBL225284	2353	5	None	-4	6	Human	9.7	pKi	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	17649988
		23643664	2350	8	None	1	5	Human	9.9	pKi	=	9.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	17649988
		8434	2350	8	None	1	5	Human	9.9	pKi	=	9.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	17649988
		CHEMBL243954	2350	8	None	1	5	Human	9.9	pKi	=	9.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	17649988
		162265	202274	22	None	-16	43	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		4786	202274	22	None	-16	43	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		CHEMBL61006	202274	22	None	-16	43	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		3337	206367	27	None	-169	40	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	206367	27	None	-169	40	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	206367	27	None	-169	40	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	206367	27	None	-169	40	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	206367	27	None	-169	40	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		202	1508	77	None	-1	30	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		60835	1508	77	None	-1	30	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		972	1508	77	None	-1	30	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		CHEMBL1175	1508	77	None	-1	30	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		DB00476	1508	77	None	-1	30	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		213	3853	55	None	-9	44	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		2717	3853	55	None	-9	44	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		5533	3853	55	None	-9	44	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		CHEMBL621	3853	55	None	-9	44	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		DB00656	3853	55	None	-9	44	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		119570	3159	96	None	-154	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		2233	3159	96	None	-154	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		953	3159	96	None	-154	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		CHEMBL301265	3159	96	None	-154	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		DB00413	3159	96	None	-154	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		179	400	115	None	-9	49	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		2159	400	115	None	-9	49	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		963	400	115	None	-9	49	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		CHEMBL243712	400	115	None	-9	49	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		DB06288	400	115	None	-9	49	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		2726	919	68	None	-301	72	Mouse	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	8394987
		621	919	68	None	-301	72	Mouse	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	8394987
		83	919	68	None	-301	72	Mouse	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	8394987
		CHEMBL71	919	68	None	-301	72	Mouse	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	8394987
		DB00477	919	68	None	-301	72	Mouse	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	8394987
		18971832	2418	0	None	-812	13	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	9395253
		21	2418	0	None	-812	13	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	9395253
		CHEMBL3186179	2418	0	None	-812	13	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	9395253
		257	3493	13	None	-13182	3	Human	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	474	6	1	6	3.3	CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N	11414657
		5311423	3493	13	None	-13182	3	Human	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	474	6	1	6	3.3	CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N	11414657
		CHEMBL114112	3493	13	None	-13182	3	Human	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	474	6	1	6	3.3	CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N	11414657
		29	792	0	None	-5011	9	Human	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	456	5	1	8	3.4	Nc1c(Cl)cc(c2c1OCCO2)c1nn(c(=O)o1)C1CCN(CC1)CCc1ccccc1	12130738
		9805719	792	0	None	-5011	9	Human	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	456	5	1	8	3.4	Nc1c(Cl)cc(c2c1OCCO2)c1nn(c(=O)o1)C1CCN(CC1)CCc1ccccc1	12130738
		CHEMBL2027925	792	0	None	-5011	9	Human	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	456	5	1	8	3.4	Nc1c(Cl)cc(c2c1OCCO2)c1nn(c(=O)o1)C1CCN(CC1)CCc1ccccc1	12130738
		102	4127	48	None	-851	49	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8226867
		3659	4127	48	None	-851	49	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8226867
		8969	4127	48	None	-851	49	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8226867
		CHEMBL15245	4127	48	None	-851	49	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8226867
		DB01392	4127	48	None	-851	49	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8226867
		240	944	43	None	-19	24	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	8394987
		2769	944	43	None	-19	24	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	8394987
		44279790	944	43	None	-19	24	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	8394987
		660	944	43	None	-19	24	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	8394987
		CHEMBL1729	944	43	None	-19	24	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	8394987
		CHEMBL560739	944	43	None	-19	24	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	8394987
		DB00604	944	43	None	-19	24	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	8394987
		2543	3707	68	None	-93	32	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8226867
		2543	3707	68	None	-93	32	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	9298538
		5358	3707	68	None	-93	32	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8226867
		5358	3707	68	None	-93	32	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	9298538
		54	3707	68	None	-93	32	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8226867
		54	3707	68	None	-93	32	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	9298538
		CHEMBL128	3707	68	None	-93	32	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8226867
		CHEMBL128	3707	68	None	-93	32	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	9298538
		DB00669	3707	68	None	-93	32	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8226867
		DB00669	3707	68	None	-93	32	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	9298538
		1524	2181	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	11414657
		1524	2181	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8226867
		1524	2181	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9298538
		1524	2181	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9720804
		197	2181	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	11414657
		197	2181	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8226867
		197	2181	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9298538
		197	2181	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9720804
		3822	2181	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	11414657
		3822	2181	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8226867
		3822	2181	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9298538
		3822	2181	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9720804
		88	2181	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	11414657
		88	2181	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8226867
		88	2181	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9298538
		88	2181	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9720804
		CHEMBL51	2181	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	11414657
		CHEMBL51	2181	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8226867
		CHEMBL51	2181	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9298538
		CHEMBL51	2181	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9720804
		DB12465	2181	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	11414657
		DB12465	2181	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8226867
		DB12465	2181	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9298538
		DB12465	2181	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9720804
		1353	1911	93	None	-74	83	Mouse	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8394987
		3559	1911	93	None	-74	83	Mouse	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8394987
		86	1911	93	None	-74	83	Mouse	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8394987
		CHEMBL54	1911	93	None	-74	83	Mouse	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8394987
		DB00502	1911	93	None	-74	83	Mouse	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8394987
		115	3791	80	None	-12	27	Mouse	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	8394987
		4296	3791	80	None	-12	27	Mouse	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	8394987
		CHEMBL274866	3791	80	None	-12	27	Mouse	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	8394987
		2543	3707	68	None	-44	32	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8394362
		2543	3707	68	None	-44	32	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8397408
		5358	3707	68	None	-44	32	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8394362
		5358	3707	68	None	-44	32	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8397408
		54	3707	68	None	-44	32	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8394362
		54	3707	68	None	-44	32	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8397408
		CHEMBL128	3707	68	None	-44	32	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8394362
		CHEMBL128	3707	68	None	-44	32	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8397408
		DB00669	3707	68	None	-44	32	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8394362
		DB00669	3707	68	None	-44	32	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8397408
		180	401	56	None	-99	40	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8394987
		200	401	56	None	-99	40	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8394987
		2160	401	56	None	-99	40	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8394987
		CHEMBL629	401	56	None	-99	40	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8394987
		DB00321	401	56	None	-99	40	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8394987
		2477	745	59	None	-7	29	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	8394987
		2477	745	59	None	-21	29	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	8397408
		36	745	59	None	-7	29	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	8394987
		36	745	59	None	-21	29	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	8397408
		437	745	59	None	-7	29	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	8394987
		437	745	59	None	-21	29	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	8397408
		CHEMBL49	745	59	None	-7	29	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	8394987
		CHEMBL49	745	59	None	-21	29	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	8397408
		DB00490	745	59	None	-7	29	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	8394987
		DB00490	745	59	None	-21	29	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	8397408
		1524	2181	96	None	-38	52	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394987
		197	2181	96	None	-38	52	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394987
		3822	2181	96	None	-38	52	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394987
		88	2181	96	None	-38	52	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394987
		CHEMBL51	2181	96	None	-38	52	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394987
		DB12465	2181	96	None	-38	52	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394987
		1353	1911	93	None	-263	83	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	9298538
		1353	1911	93	None	-120	83	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	7908055
		1353	1911	93	None	-120	83	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8397408
		1353	1911	93	None	-120	83	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8997630
		3559	1911	93	None	-263	83	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	9298538
		3559	1911	93	None	-120	83	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	7908055
		3559	1911	93	None	-120	83	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8397408
		3559	1911	93	None	-120	83	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8997630
		86	1911	93	None	-263	83	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	9298538
		86	1911	93	None	-120	83	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	7908055
		86	1911	93	None	-120	83	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8397408
		86	1911	93	None	-120	83	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8997630
		CHEMBL54	1911	93	None	-263	83	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	9298538
		CHEMBL54	1911	93	None	-120	83	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	7908055
		CHEMBL54	1911	93	None	-120	83	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8397408
		CHEMBL54	1911	93	None	-120	83	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8997630
		DB00502	1911	93	None	-263	83	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	9298538
		DB00502	1911	93	None	-120	83	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	7908055
		DB00502	1911	93	None	-120	83	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8397408
		DB00502	1911	93	None	-120	83	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8997630
		115	3791	80	None	-8	27	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	8394362
		4296	3791	80	None	-8	27	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	8394362
		CHEMBL274866	3791	80	None	-8	27	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	8394362
		1355	2011	88	None	-21	16	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	8394362
		142	2011	88	None	-21	16	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	8394362
		CHEMBL478	2011	88	None	-21	16	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	8394362
		DB12110	2011	88	None	-21	16	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	8394362
		282	1419	0	None	-3548	7	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	577	5	3	6	2.5	CC(CC1C(=O)N2CCCC2C2(N1C(=O)C(O2)(NC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	8397408
		522609	1419	0	None	-3548	7	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	577	5	3	6	2.5	CC(CC1C(=O)N2CCCC2C2(N1C(=O)C(O2)(NC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	8397408
		12	1553	17	None	-13	7	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10715164
		6918513	1553	17	None	-13	7	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10715164
		CHEMBL267615	1553	17	None	-13	7	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10715164
		135398745	2914	112	None	-95	65	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	9720804
		47	2914	112	None	-95	65	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	9720804
		CHEMBL715	2914	112	None	-95	65	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	9720804
		DB00334	2914	112	None	-95	65	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	9720804
		1220	187	55	None	-199	44	Mouse	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8394987
		31	187	55	None	-199	44	Mouse	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8394987
		7	187	55	None	-199	44	Mouse	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8394987
		CHEMBL56	187	55	None	-199	44	Mouse	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8394987
		1524	2181	96	None	-169	52	Rat	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394362
		197	2181	96	None	-169	52	Rat	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394362
		3822	2181	96	None	-169	52	Rat	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394362
		88	2181	96	None	-169	52	Rat	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394362
		CHEMBL51	2181	96	None	-169	52	Rat	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394362
		DB12465	2181	96	None	-169	52	Rat	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394362
		267	1447	0	None	1	2	Rat	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	463	7	2	5	4.6	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1ccc(c(c1Cl)Cl)O	10327430
		9847259	1447	0	None	1	2	Rat	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	463	7	2	5	4.6	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1ccc(c(c1Cl)Cl)O	10327430
		CHEMBL4214961	1447	0	None	1	2	Rat	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	463	7	2	5	4.6	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1ccc(c(c1Cl)Cl)O	10327430
		1346	83	117	None	-147	9	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	8394362
		280	83	117	None	-147	9	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	8394362
		9899402	83	117	None	-147	9	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	8394362
		CHEMBL9666	83	117	None	-147	9	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	8394362
		10531	1420	21	None	-87	23	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8397408
		121	1420	21	None	-87	23	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8397408
		888	1420	21	None	-87	23	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8397408
		CHEMBL1732	1420	21	None	-87	23	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8397408
		DB00320	1420	21	None	-87	23	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8397408
		6918515	2612	38	None	-4	7	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	294	5	1	2	3.9	COc1ccc2c(c1)c(CCN(C)C)c([nH]2)c1ccccc1	10715164
		71	2612	38	None	-4	7	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	294	5	1	2	3.9	COc1ccc2c(c1)c(CCN(C)C)c([nH]2)c1ccccc1	10715164
		CHEMBL7318	2612	38	None	-4	7	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	294	5	1	2	3.9	COc1ccc2c(c1)c(CCN(C)C)c([nH]2)c1ccccc1	10715164
		1150	3878	121	None	-6	25	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8226867
		125	3878	121	None	-6	25	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8226867
		CHEMBL6640	3878	121	None	-6	25	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8226867
		DB08653	3878	121	None	-6	25	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8226867
		135398745	2914	112	None	-34	65	Rat	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	7908055
		135398745	2914	112	None	-34	65	Rat	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	8997630
		47	2914	112	None	-34	65	Rat	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	7908055
		47	2914	112	None	-34	65	Rat	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	8997630
		CHEMBL715	2914	112	None	-34	65	Rat	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	7908055
		CHEMBL715	2914	112	None	-34	65	Rat	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	8997630
		DB00334	2914	112	None	-34	65	Rat	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	7908055
		DB00334	2914	112	None	-34	65	Rat	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	8997630
		277	1301	62	None	-63	50	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8226867
		2913	1301	62	None	-63	50	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8226867
		765	1301	62	None	-63	50	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8226867
		CHEMBL516	1301	62	None	-63	50	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8226867
		DB00434	1301	62	None	-63	50	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8226867
		108029	3414	57	None	-125	13	Mouse	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	2	2	2	2.6	COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1	8394987
		23	3414	57	None	-125	13	Mouse	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	2	2	2	2.6	COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1	8394987
		CHEMBL18785	3414	57	None	-125	13	Mouse	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	2	2	2	2.6	COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1	8394987
		3652	4097	79	None	-6	18	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
		57	4097	79	None	-6	18	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
		60809	4097	79	None	-6	18	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
		CHEMBL21536	4097	79	None	-6	18	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
		DB15357	4097	79	None	-6	18	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
		1220	187	55	None	-208	44	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	11414657
		1220	187	55	None	-208	44	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8226867
		1220	187	55	None	-208	44	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	9298538
		1220	187	55	None	-208	44	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	9720804
		31	187	55	None	-208	44	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	11414657
		31	187	55	None	-208	44	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8226867
		31	187	55	None	-208	44	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	9298538
		31	187	55	None	-208	44	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	9720804
		7	187	55	None	-208	44	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	11414657
		7	187	55	None	-208	44	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8226867
		7	187	55	None	-208	44	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	9298538
		7	187	55	None	-208	44	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	9720804
		CHEMBL56	187	55	None	-208	44	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	11414657
		CHEMBL56	187	55	None	-208	44	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8226867
		CHEMBL56	187	55	None	-208	44	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	9298538
		CHEMBL56	187	55	None	-208	44	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	9720804
		180	401	56	None	-125	40	Rat	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8394362
		200	401	56	None	-125	40	Rat	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8394362
		2160	401	56	None	-125	40	Rat	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8394362
		CHEMBL629	401	56	None	-125	40	Rat	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8394362
		DB00321	401	56	None	-125	40	Rat	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8394362
		10257	738	31	None	-39	19	Mouse	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	8394987
		144	738	31	None	-39	19	Mouse	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	8394987
		CHEMBL416526	738	31	None	-39	19	Mouse	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	8394987
		DB01445	738	31	None	-39	19	Mouse	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	8394987
		37459	746	13	None	-194	25	Rat	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	8397408
		62	746	13	None	-194	25	Rat	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	8397408
		CHEMBL8514	746	13	None	-194	25	Rat	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	8397408
		282	1419	0	None	-1122	7	Mouse	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	577	5	3	6	2.5	CC(CC1C(=O)N2CCCC2C2(N1C(=O)C(O2)(NC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	8394987
		522609	1419	0	None	-1122	7	Mouse	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	577	5	3	6	2.5	CC(CC1C(=O)N2CCCC2C2(N1C(=O)C(O2)(NC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	8394987
		3294	2006	111	None	-41	45	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	11750183
		71360	2006	111	None	-41	45	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	11750183
		87	2006	111	None	-41	45	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	11750183
		CHEMBL14376	2006	111	None	-41	45	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	11750183
		DB04946	2006	111	None	-41	45	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	11750183
		135	2532	43	None	-21	58	Mouse	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8394987
		1796	2532	43	None	-21	58	Mouse	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8394987
		4184	2532	43	None	-21	58	Mouse	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8394987
		CHEMBL6437	2532	43	None	-21	58	Mouse	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8394987
		DB06148	2532	43	None	-21	58	Mouse	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8394987
		1613	2348	53	None	-14	44	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	7908055
		1613	2348	53	None	-14	44	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	8394362
		205	2348	53	None	-14	44	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	7908055
		205	2348	53	None	-14	44	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	8394362
		3964	2348	53	None	-14	44	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	7908055
		3964	2348	53	None	-14	44	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	8394362
		CHEMBL831	2348	53	None	-14	44	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	7908055
		CHEMBL831	2348	53	None	-14	44	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	8394362
		DB00408	2348	53	None	-14	44	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	7908055
		DB00408	2348	53	None	-14	44	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	8394362
		5074	3332	80	None	-69	30	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	11414657
		5074	3332	80	None	-69	30	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8226867
		97	3332	80	None	-69	30	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	11414657
		97	3332	80	None	-69	30	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8226867
		CHEMBL267777	3332	80	None	-69	30	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	11414657
		CHEMBL267777	3332	80	None	-69	30	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8226867
		DB12693	3332	80	None	-69	30	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	11414657
		DB12693	3332	80	None	-69	30	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8226867
		1342	35	49	None	-33	19	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8226867
		3	35	49	None	-33	19	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8226867
		CHEMBL277120	35	49	None	-33	19	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8226867
		100	3805	58	None	-28	55	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	15821958
		2637	3805	58	None	-28	55	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	15821958
		5452	3805	58	None	-28	55	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	15821958
		CHEMBL479	3805	58	None	-28	55	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	15821958
		DB00679	3805	58	None	-28	55	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	15821958
		135	2532	43	None	-50	58	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8394362
		135	2532	43	None	-50	58	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8397408
		1796	2532	43	None	-50	58	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8394362
		1796	2532	43	None	-50	58	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8397408
		4184	2532	43	None	-50	58	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8394362
		4184	2532	43	None	-50	58	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8397408
		CHEMBL6437	2532	43	None	-50	58	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8394362
		CHEMBL6437	2532	43	None	-50	58	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8397408
		DB06148	2532	43	None	-50	58	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8394362
		DB06148	2532	43	None	-50	58	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8397408
		62865	1274	0	None	-7	14	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	12527336
		746	1274	0	None	-7	14	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	12527336
		84	1274	0	None	-7	14	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	12527336
		CHEMBL2104153	1274	0	None	-7	14	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	12527336
		DB09000	1274	0	None	-7	14	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	12527336
		209	3057	97	None	-31	23	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	15821958
		2113	3057	97	None	-31	23	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	15821958
		4748	3057	97	None	-31	23	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	15821958
		CHEMBL567	3057	97	None	-31	23	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	15821958
		DB00850	3057	97	None	-31	23	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	15821958
		2470	3653	50	None	-1096	59	Mouse	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8394987
		3300	3653	50	None	-1096	59	Mouse	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8394987
		5265	3653	50	None	-1096	59	Mouse	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8394987
		99	3653	50	None	-1096	59	Mouse	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8394987
		CHEMBL267930	3653	50	None	-1096	59	Mouse	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8394987
		100	3805	58	None	-18	55	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	7908055
		2637	3805	58	None	-18	55	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	7908055
		5452	3805	58	None	-18	55	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	7908055
		CHEMBL479	3805	58	None	-18	55	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	7908055
		DB00679	3805	58	None	-18	55	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	7908055
		277	1301	62	None	-43	50	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8394362
		277	1301	62	None	-43	50	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8397408
		2913	1301	62	None	-43	50	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8394362
		2913	1301	62	None	-43	50	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8397408
		765	1301	62	None	-43	50	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8394362
		765	1301	62	None	-43	50	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8397408
		CHEMBL516	1301	62	None	-43	50	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8394362
		CHEMBL516	1301	62	None	-43	50	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8397408
		DB00434	1301	62	None	-43	50	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8394362
		DB00434	1301	62	None	-43	50	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8397408
		1043	1582	14	None	-549	28	Mouse	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8394987
		149	1582	14	None	-549	28	Mouse	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8394987
		8223	1582	14	None	-549	28	Mouse	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8394987
		CHEMBL442	1582	14	None	-549	28	Mouse	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8394987
		DB00696	1582	14	None	-549	28	Mouse	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8394987
		1220	187	55	None	-75	44	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8394362
		1220	187	55	None	-75	44	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8397408
		31	187	55	None	-75	44	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8394362
		31	187	55	None	-75	44	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8397408
		7	187	55	None	-75	44	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8394362
		7	187	55	None	-75	44	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8397408
		CHEMBL56	187	55	None	-75	44	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8394362
		CHEMBL56	187	55	None	-75	44	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8397408
		191	403	98	None	-19	29	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	7908055
		201	403	98	None	-19	29	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	7908055
		2170	403	98	None	-19	29	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	7908055
		CHEMBL1113	403	98	None	-19	29	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	7908055
		DB00543	403	98	None	-19	29	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	7908055
		135398737	958	93	None	-9	89	Mouse	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8394987
		38	958	93	None	-9	89	Mouse	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8394987
		722	958	93	None	-9	89	Mouse	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8394987
		CHEMBL42	958	93	None	-9	89	Mouse	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8394987
		DB00363	958	93	None	-9	89	Mouse	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8394987
		134	2514	24	None	-24	67	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	11414657
		134	2514	24	None	-24	67	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8226867
		134	2514	24	None	-24	67	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	9298538
		1775	2514	24	None	-24	67	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	11414657
		1775	2514	24	None	-24	67	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8226867
		1775	2514	24	None	-24	67	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	9298538
		9681	2514	24	None	-24	67	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	11414657
		9681	2514	24	None	-24	67	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8226867
		9681	2514	24	None	-24	67	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	9298538
		CHEMBL1065	2514	24	None	-24	67	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	11414657
		CHEMBL1065	2514	24	None	-24	67	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8226867
		CHEMBL1065	2514	24	None	-24	67	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	9298538
		DB00247	2514	24	None	-24	67	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	11414657
		DB00247	2514	24	None	-24	67	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8226867
		DB00247	2514	24	None	-24	67	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	9298538
		135	2532	43	None	-83	58	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	9298538
		1796	2532	43	None	-83	58	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	9298538
		4184	2532	43	None	-83	58	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	9298538
		CHEMBL6437	2532	43	None	-83	58	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	9298538
		DB06148	2532	43	None	-83	58	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	9298538
		2470	3653	50	None	-1258	59	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	11414657
		2470	3653	50	None	-1258	59	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8226867
		2470	3653	50	None	-1258	59	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	9298538
		3300	3653	50	None	-1258	59	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	11414657
		3300	3653	50	None	-1258	59	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8226867
		3300	3653	50	None	-1258	59	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	9298538
		5265	3653	50	None	-1258	59	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	11414657
		5265	3653	50	None	-1258	59	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8226867
		5265	3653	50	None	-1258	59	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	9298538
		99	3653	50	None	-1258	59	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	11414657
		99	3653	50	None	-1258	59	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8226867
		99	3653	50	None	-1258	59	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	9298538
		CHEMBL267930	3653	50	None	-1258	59	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	11414657
		CHEMBL267930	3653	50	None	-1258	59	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8226867
		CHEMBL267930	3653	50	None	-1258	59	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	9298538
		135398737	958	93	None	-13	89	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11414657
		135398737	958	93	None	-13	89	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15821958
		135398737	958	93	None	-13	89	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9720804
		38	958	93	None	-13	89	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11414657
		38	958	93	None	-13	89	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15821958
		38	958	93	None	-13	89	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9720804
		722	958	93	None	-13	89	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11414657
		722	958	93	None	-13	89	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15821958
		722	958	93	None	-13	89	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9720804
		CHEMBL42	958	93	None	-13	89	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11414657
		CHEMBL42	958	93	None	-13	89	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15821958
		CHEMBL42	958	93	None	-13	89	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9720804
		DB00363	958	93	None	-13	89	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11414657
		DB00363	958	93	None	-13	89	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15821958
		DB00363	958	93	None	-13	89	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9720804
		10171	56	18	None	-11	6	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	8226867
		272	56	18	None	-11	6	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	8226867
		CHEMBL274384	56	18	None	-11	6	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	8226867
		37459	746	13	None	-74	25	Mouse	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	8394987
		62	746	13	None	-74	25	Mouse	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	8394987
		CHEMBL8514	746	13	None	-74	25	Mouse	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	8394987
		279	1661	26	None	-6	18	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	15821958
		49381	1661	26	None	-6	18	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	15821958
		CHEMBL63756	1661	26	None	-6	18	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	15821958
		133	2496	52	None	-36	42	Mouse	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8394987
		1723	2496	52	None	-36	42	Mouse	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8394987
		28693	2496	52	None	-36	42	Mouse	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8394987
		CHEMBL19215	2496	52	None	-36	42	Mouse	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8394987
		DB13520	2496	52	None	-36	42	Mouse	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8394987
		145	140	49	None	-4	30	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	8394362
		1832	140	49	None	-4	30	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	8394362
		CHEMBL7257	140	49	None	-4	30	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	8394362
		DB14010	140	49	None	-4	30	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	8394362
		1342	35	49	None	-13	19	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8394362
		3	35	49	None	-13	19	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8394362
		CHEMBL277120	35	49	None	-13	19	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8394362
		2726	919	68	None	-13	72	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	15821958
		2726	919	68	None	-13	72	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	7908055
		621	919	68	None	-13	72	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	15821958
		621	919	68	None	-13	72	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	7908055
		83	919	68	None	-13	72	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	15821958
		83	919	68	None	-13	72	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	7908055
		CHEMBL71	919	68	None	-13	72	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	15821958
		CHEMBL71	919	68	None	-13	72	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	7908055
		DB00477	919	68	None	-13	72	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	15821958
		DB00477	919	68	None	-13	72	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	7908055
		206	2493	16	None	-16	25	Mouse	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8394987
		68848	2493	16	None	-16	25	Mouse	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8394987
		CHEMBL12314	2493	16	None	-16	25	Mouse	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8394987
		209	3057	97	None	-25	23	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	7908055
		2113	3057	97	None	-25	23	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	7908055
		4748	3057	97	None	-25	23	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	7908055
		CHEMBL567	3057	97	None	-25	23	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	7908055
		DB00850	3057	97	None	-25	23	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	7908055
		31101	729	40	None	-25	36	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	8394362
		35	729	40	None	-25	36	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	8394362
		403	729	40	None	-25	36	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	8394362
		CHEMBL493	729	40	None	-25	36	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	8394362
		DB01200	729	40	None	-25	36	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	8394362
		1150	3878	121	None	1	25	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8394362
		125	3878	121	None	1	25	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8394362
		CHEMBL6640	3878	121	None	1	25	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8394362
		DB08653	3878	121	None	1	25	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8394362
		135398737	958	93	None	-7	89	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	7908055
		135398737	958	93	None	-7	89	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8394362
		135398737	958	93	None	-7	89	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8397408
		135398737	958	93	None	-7	89	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8997630
		38	958	93	None	-7	89	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	7908055
		38	958	93	None	-7	89	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8394362
		38	958	93	None	-7	89	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8397408
		38	958	93	None	-7	89	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8997630
		722	958	93	None	-7	89	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	7908055
		722	958	93	None	-7	89	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8394362
		722	958	93	None	-7	89	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8397408
		722	958	93	None	-7	89	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8997630
		CHEMBL42	958	93	None	-7	89	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	7908055
		CHEMBL42	958	93	None	-7	89	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8394362
		CHEMBL42	958	93	None	-7	89	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8397408
		CHEMBL42	958	93	None	-7	89	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8997630
		DB00363	958	93	None	-7	89	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	7908055
		DB00363	958	93	None	-7	89	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8394362
		DB00363	958	93	None	-7	89	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8397408
		DB00363	958	93	None	-7	89	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8997630
		3294	2006	111	None	-21	45	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	8997630
		71360	2006	111	None	-21	45	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	8997630
		87	2006	111	None	-21	45	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	8997630
		CHEMBL14376	2006	111	None	-21	45	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	8997630
		DB04946	2006	111	None	-21	45	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	8997630
		163839	2955	0	None	-1	7	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	391	6	1	4	3.7	Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2	10327430
		268	2955	0	None	-1	7	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	391	6	1	4	3.7	Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2	10327430
		CHEMBL55171	2955	0	None	-1	7	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	391	6	1	4	3.7	Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2	10327430
		5074	3332	80	None	-36	30	Rat	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8394362
		97	3332	80	None	-36	30	Rat	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8394362
		CHEMBL267777	3332	80	None	-36	30	Rat	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8394362
		DB12693	3332	80	None	-36	30	Rat	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8394362
		206	2493	16	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	11414657
		206	2493	16	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8226867
		206	2493	16	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	9298538
		206	2493	16	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	9720804
		68848	2493	16	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	11414657
		68848	2493	16	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8226867
		68848	2493	16	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	9298538
		68848	2493	16	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	9720804
		CHEMBL12314	2493	16	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	11414657
		CHEMBL12314	2493	16	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8226867
		CHEMBL12314	2493	16	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	9298538
		CHEMBL12314	2493	16	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	9720804
		2470	3653	50	None	-389	59	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	7908055
		2470	3653	50	None	-389	59	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8397408
		3300	3653	50	None	-389	59	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	7908055
		3300	3653	50	None	-389	59	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8397408
		5265	3653	50	None	-389	59	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	7908055
		5265	3653	50	None	-389	59	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8397408
		99	3653	50	None	-389	59	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	7908055
		99	3653	50	None	-389	59	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8397408
		CHEMBL267930	3653	50	None	-389	59	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	7908055
		CHEMBL267930	3653	50	None	-389	59	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8397408
		1212	1662	50	None	-18	65	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	15821958
		204	1662	50	None	-18	65	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	15821958
		3372	1662	50	None	-18	65	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	15821958
		CHEMBL726	1662	50	None	-18	65	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	15821958
		DB00623	1662	50	None	-18	65	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	15821958
		134	2514	24	None	-9	67	Mouse	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8394987
		134	2514	24	None	-18	67	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8394362
		1775	2514	24	None	-9	67	Mouse	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8394987
		1775	2514	24	None	-18	67	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8394362
		9681	2514	24	None	-9	67	Mouse	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8394987
		9681	2514	24	None	-18	67	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8394362
		CHEMBL1065	2514	24	None	-9	67	Mouse	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8394987
		CHEMBL1065	2514	24	None	-18	67	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8394362
		DB00247	2514	24	None	-9	67	Mouse	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8394987
		DB00247	2514	24	None	-18	67	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8394362
		133	2496	52	None	-16	42	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8394362
		133	2496	52	None	-16	42	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8397408
		1723	2496	52	None	-16	42	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8394362
		1723	2496	52	None	-16	42	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8397408
		28693	2496	52	None	-16	42	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8394362
		28693	2496	52	None	-16	42	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8397408
		CHEMBL19215	2496	52	None	-16	42	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8394362
		CHEMBL19215	2496	52	None	-16	42	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8397408
		DB13520	2496	52	None	-16	42	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8394362
		DB13520	2496	52	None	-16	42	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8397408
		206	2493	16	None	-6	25	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8394362
		68848	2493	16	None	-6	25	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8394362
		CHEMBL12314	2493	16	None	-6	25	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8394362
		10171	56	18	None	-5	6	Mouse	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	8394987
		272	56	18	None	-5	6	Mouse	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	8394987
		CHEMBL274384	56	18	None	-5	6	Mouse	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	8394987
		10531	1420	21	None	-23	23	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8226867
		121	1420	21	None	-23	23	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8226867
		888	1420	21	None	-23	23	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8226867
		CHEMBL1732	1420	21	None	-23	23	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8226867
		DB00320	1420	21	None	-23	23	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8226867
		154	2359	0	None	-12	4	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8397408
		638252	2359	0	None	-12	4	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8397408
		1212	1662	50	None	-15	65	Rat	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7908055
		204	1662	50	None	-15	65	Rat	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7908055
		3372	1662	50	None	-15	65	Rat	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7908055
		CHEMBL726	1662	50	None	-15	65	Rat	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7908055
		DB00623	1662	50	None	-15	65	Rat	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7908055
		107	141	121	None	-9	30	Mouse	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8394987
		1833	141	121	None	-9	30	Mouse	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8394987
		CHEMBL8165	141	121	None	-9	30	Mouse	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8394987
		4106	2502	22	None	-15	34	Mouse	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8394987
		5358812	2502	22	None	-15	34	Mouse	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8394987
		89	2502	22	None	-15	34	Mouse	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8394987
		CHEMBL93240	2502	22	None	-15	34	Mouse	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8394987
		122	1437	9	None	1	11	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	9298538
		156314	1437	9	None	1	11	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	9298538
		CHEMBL1332062	1437	9	None	1	11	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	9298538
		5	139	72	None	-11	54	Mouse	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8394987
		5202	139	72	None	-11	54	Mouse	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8394987
		CHEMBL39	139	72	None	-11	54	Mouse	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8394987
		DB08839	139	72	None	-11	54	Mouse	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8394987
		279	1661	26	None	1	18	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	7908055
		49381	1661	26	None	1	18	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	7908055
		CHEMBL63756	1661	26	None	1	18	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	7908055
		283	3130	57	None	-4	12	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	9298538
		4847	3130	57	None	-4	12	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	9298538
		CHEMBL18331	3130	57	None	-4	12	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	9298538
		2865	4143	73	None	-12	53	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	15821958
		59	4143	73	None	-12	53	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	15821958
		60854	4143	73	None	-12	53	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	15821958
		CHEMBL708	4143	73	None	-12	53	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	15821958
		DB00246	4143	73	None	-12	53	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	15821958
		103	4153	61	None	-6	53	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	15821958
		2875	4153	61	None	-6	53	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	15821958
		5736	4153	61	None	-6	53	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	15821958
		CHEMBL285802	4153	61	None	-6	53	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	15821958
		DB09225	4153	61	None	-6	53	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	15821958
		2389	3331	118	None	-8	67	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	15821958
		2389	3331	118	None	-8	67	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	9720804
		5073	3331	118	None	-8	67	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	15821958
		5073	3331	118	None	-8	67	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	9720804
		96	3331	118	None	-8	67	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	15821958
		96	3331	118	None	-8	67	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	9720804
		CHEMBL85	3331	118	None	-8	67	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	15821958
		CHEMBL85	3331	118	None	-8	67	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	9720804
		DB00734	3331	118	None	-8	67	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	15821958
		DB00734	3331	118	None	-8	67	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	9720804
		133	2496	52	None	-10	42	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	11414657
		133	2496	52	None	-10	42	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8226867
		133	2496	52	None	-10	42	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	9298538
		1723	2496	52	None	-10	42	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	11414657
		1723	2496	52	None	-10	42	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8226867
		1723	2496	52	None	-10	42	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	9298538
		28693	2496	52	None	-10	42	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	11414657
		28693	2496	52	None	-10	42	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8226867
		28693	2496	52	None	-10	42	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	9298538
		CHEMBL19215	2496	52	None	-10	42	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	11414657
		CHEMBL19215	2496	52	None	-10	42	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8226867
		CHEMBL19215	2496	52	None	-10	42	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	9298538
		DB13520	2496	52	None	-10	42	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	11414657
		DB13520	2496	52	None	-10	42	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8226867
		DB13520	2496	52	None	-10	42	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	9298538
		2105	3054	37	None	-5	33	Rat	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	8394362
		47811	3054	37	None	-5	33	Rat	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	8394362
		48	3054	37	None	-5	33	Rat	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	8394362
		CHEMBL531	3054	37	None	-5	33	Rat	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	8394362
		DB01186	3054	37	None	-5	33	Rat	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	8394362
		1588	2325	27	None	-6	44	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8394362
		1588	2325	27	None	-6	44	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8397408
		28864	2325	27	None	-6	44	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8394362
		28864	2325	27	None	-6	44	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8397408
		43	2325	27	None	-6	44	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8394362
		43	2325	27	None	-6	44	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8397408
		CHEMBL157138	2325	27	None	-6	44	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8394362
		CHEMBL157138	2325	27	None	-6	44	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8397408
		DB00589	2325	27	None	-6	44	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8394362
		DB00589	2325	27	None	-6	44	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8397408
		103	4153	61	None	-2	53	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	7908055
		2875	4153	61	None	-2	53	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	7908055
		5736	4153	61	None	-2	53	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	7908055
		CHEMBL285802	4153	61	None	-2	53	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	7908055
		DB09225	4153	61	None	-2	53	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	7908055
		5	139	72	None	-3	54	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	11414657
		5	139	72	None	-3	54	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	12527336
		5	139	72	None	-3	54	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8226867
		5	139	72	None	-3	54	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	9298538
		5	139	72	None	-3	54	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	9720804
		5202	139	72	None	-3	54	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	11414657
		5202	139	72	None	-3	54	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	12527336
		5202	139	72	None	-3	54	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8226867
		5202	139	72	None	-3	54	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	9298538
		5202	139	72	None	-3	54	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	9720804
		CHEMBL39	139	72	None	-3	54	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	11414657
		CHEMBL39	139	72	None	-3	54	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	12527336
		CHEMBL39	139	72	None	-3	54	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8226867
		CHEMBL39	139	72	None	-3	54	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	9298538
		CHEMBL39	139	72	None	-3	54	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	9720804
		DB08839	139	72	None	-3	54	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	11414657
		DB08839	139	72	None	-3	54	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	12527336
		DB08839	139	72	None	-3	54	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8226867
		DB08839	139	72	None	-3	54	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	9298538
		DB08839	139	72	None	-3	54	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	9720804
		107	141	121	None	-3	30	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	11414657
		107	141	121	None	-3	30	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8226867
		107	141	121	None	-3	30	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	9298538
		1833	141	121	None	-3	30	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	11414657
		1833	141	121	None	-3	30	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8226867
		1833	141	121	None	-3	30	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	9298538
		CHEMBL8165	141	121	None	-3	30	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	11414657
		CHEMBL8165	141	121	None	-3	30	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8226867
		CHEMBL8165	141	121	None	-3	30	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	9298538
		4106	2502	22	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	11414657
		4106	2502	22	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8226867
		4106	2502	22	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9298538
		4106	2502	22	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9720804
		5358812	2502	22	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	11414657
		5358812	2502	22	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8226867
		5358812	2502	22	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9298538
		5358812	2502	22	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9720804
		89	2502	22	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	11414657
		89	2502	22	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8226867
		89	2502	22	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9298538
		89	2502	22	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9720804
		CHEMBL93240	2502	22	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	11414657
		CHEMBL93240	2502	22	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8226867
		CHEMBL93240	2502	22	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9298538
		CHEMBL93240	2502	22	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9720804
		107	141	121	None	-1	30	Rat	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8394362
		107	141	121	None	-1	30	Rat	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8397408
		1833	141	121	None	-1	30	Rat	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8394362
		1833	141	121	None	-1	30	Rat	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8397408
		CHEMBL8165	141	121	None	-1	30	Rat	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8394362
		CHEMBL8165	141	121	None	-1	30	Rat	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8397408
		1809	134	32	None	-12	36	Mouse	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8394987
		4	134	32	None	-12	36	Mouse	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8394987
		CHEMBL18840	134	32	None	-12	36	Mouse	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8394987
		4106	2502	22	None	-2	34	Rat	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8394362
		5358812	2502	22	None	-2	34	Rat	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8394362
		89	2502	22	None	-2	34	Rat	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8394362
		CHEMBL93240	2502	22	None	-2	34	Rat	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8394362
		101	3822	24	None	-2	14	Rat	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	440	6	0	6	3.9	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2	7908055
		55752	3822	24	None	-2	14	Rat	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	440	6	0	6	3.9	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2	7908055
		CHEMBL35057	3822	24	None	-2	14	Rat	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	440	6	0	6	3.9	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2	7908055
		1809	134	32	None	-7	36	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	11414657
		1809	134	32	None	-7	36	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8226867
		1809	134	32	None	-7	36	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	9298538
		1809	134	32	None	-7	36	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	9720804
		4	134	32	None	-7	36	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	11414657
		4	134	32	None	-7	36	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8226867
		4	134	32	None	-7	36	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	9298538
		4	134	32	None	-7	36	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	9720804
		CHEMBL18840	134	32	None	-7	36	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	11414657
		CHEMBL18840	134	32	None	-7	36	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8226867
		CHEMBL18840	134	32	None	-7	36	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	9298538
		CHEMBL18840	134	32	None	-7	36	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	9720804
		1809	134	32	None	-2	36	Rat	9.7	pKi	None	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8394362
		1809	134	32	None	-2	36	Rat	9.7	pKi	None	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8397408
		4	134	32	None	-2	36	Rat	9.7	pKi	None	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8394362
		4	134	32	None	-2	36	Rat	9.7	pKi	None	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8397408
		CHEMBL18840	134	32	None	-2	36	Rat	9.7	pKi	None	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8394362
		CHEMBL18840	134	32	None	-2	36	Rat	9.7	pKi	None	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8397408

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Ligand source activities (1 row/activity)