ORF74 (q76sf8_hhv8)
FAMILY
Class A (Rhodopsin) Other Unclassified ORF74
GENE
ORF74 (HHV8GK18_gp84)
ORGANISM
HHV-8 (Human herpesvirus 8)
ALT. NAMES
G protein-coupled receptor, IL-8 receptor-like G protein coupled receptor homolog, ORF74, Putative G-protein coupled receptor
SOURCE
TREMBL
SEQUENCE
| N-term | |||||||||
|
M
|
A
|
A
|
E
|
D
|
F
|
L
|
T
|
I
|
F
|
| 10 | |||||||||
|
L
|
D
|
D
|
D
|
E
|
S
|
W
|
N
|
E
|
T
|
| 20 | |||||||||
|
L
|
N
|
M
|
S
|
G
|
Y
|
D
|
Y
|
S
|
G
|
| 30 | |||||||||
|
N
|
F
|
S
|
L
|
E
|
V
|
S
|
V
|
C
|
E
|
| 40 | |||||||||
| TM1 | |||||||||
|
M
|
T
|
T
|
V
|
V
|
P
|
Y
|
T
|
W
|
N
|
| 50 | |||||||||
|
V
|
G
|
I
|
L
|
S
|
L
|
I
|
F
|
L
|
I
|
| 60 | |||||||||
|
N
|
V
|
L
|
G
|
N
|
G
|
L
|
V
|
T
|
Y
|
| 70 | |||||||||
|
I
|
F
|
C
|
K
|
H
|
R
|
S
|
R
|
A
|
G
|
| 80 | |||||||||
| TM2 | |||||||||
|
A
|
I
|
D
|
I
|
L
|
L
|
L
|
G
|
I
|
C
|
| 90 | |||||||||
|
L
|
N
|
S
|
L
|
C
|
L
|
S
|
I
|
S
|
L
|
| 100 | |||||||||
|
L
|
A
|
E
|
V
|
L
|
M
|
F
|
L
|
F
|
P
|
| 110 | |||||||||
| ECL1 | TM3 | ||||||||
|
N
|
I
|
I
|
S
|
T
|
G
|
L
|
C
|
R
|
L
|
| 120 | |||||||||
|
E
|
I
|
F
|
F
|
Y
|
Y
|
L
|
Y
|
V
|
Y
|
| 130 | |||||||||
|
L
|
D
|
I
|
F
|
S
|
V
|
V
|
C
|
V
|
S
|
| 140 | |||||||||
|
L
|
V
|
R
|
Y
|
L
|
L
|
V
|
A
|
Y
|
S
|
| 150 | |||||||||
| ICL2 | TM4 | ||||||||
|
T
|
R
|
S
|
W
|
P
|
K
|
K
|
Q
|
S
|
L
|
| 160 | |||||||||
|
G
|
W
|
V
|
L
|
T
|
S
|
A
|
A
|
L
|
L
|
| 170 | |||||||||
|
I
|
A
|
L
|
V
|
L
|
S
|
G
|
D
|
A
|
C
|
| 180 | |||||||||
| ECL2 | |||||||||
|
R
|
H
|
R
|
S
|
R
|
V
|
V
|
D
|
P
|
V
|
| 190 | |||||||||
|
S
|
K
|
Q
|
A
|
M
|
C
|
Y
|
E
|
N
|
A
|
| 200 | |||||||||
| TM5 | |||||||||
|
G
|
N
|
M
|
T
|
A
|
D
|
W
|
R
|
L
|
H
|
| 210 | |||||||||
|
V
|
R
|
T
|
V
|
S
|
V
|
T
|
A
|
G
|
F
|
| 220 | |||||||||
|
L
|
L
|
P
|
L
|
A
|
L
|
L
|
I
|
L
|
F
|
| 230 | |||||||||
|
Y
|
A
|
L
|
T
|
W
|
C
|
V
|
V
|
R
|
R
|
| 240 | |||||||||
| ICL3 | TM6 | ||||||||
|
T
|
K
|
L
|
Q
|
A
|
R
|
R
|
K
|
V
|
R
|
| 250 | |||||||||
|
G
|
V
|
I
|
V
|
A
|
V
|
V
|
L
|
L
|
F
|
| 260 | |||||||||
|
F
|
V
|
F
|
C
|
F
|
P
|
Y
|
H
|
V
|
L
|
| 270 | |||||||||
|
N
|
L
|
L
|
D
|
T
|
L
|
L
|
R
|
R
|
R
|
| 280 | |||||||||
| ECL3 | TM7 | ||||||||
|
W
|
I
|
R
|
D
|
S
|
C
|
Y
|
T
|
R
|
G
|
| 290 | |||||||||
|
L
|
I
|
N
|
V
|
G
|
L
|
A
|
V
|
T
|
S
|
| 300 | |||||||||
|
L
|
L
|
Q
|
A
|
L
|
Y
|
S
|
A
|
V
|
V
|
| 310 | |||||||||
| H8 | |||||||||
|
P
|
L
|
I
|
Y
|
S
|
C
|
L
|
G
|
S
|
L
|
| 320 | |||||||||
|
F
|
R
|
Q
|
R
|
M
|
Y
|
G
|
L
|
F
|
Q
|
| 330 | |||||||||
|
S
|
L
|
R
|
Q
|
S
|
F
|
M
|
S
|
G
|
A
|
| 340 | |||||||||
| C-term | |||||
|
T
|
T
|
||||
LINKS
DIAGRAMS
7TM
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
No physiological ligands available
STRUCTURE MODELS
No structure models have been generated as experimental structures are available (see below).
STRUCTURES
Found 2 structure(s) - view all details on the Structures page