Beta-arrestin-2 - 5-HT1A receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
5-HT1A 82.5
Beta-arrestin-2 80.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic H8 N 409 8x52 s20c Y 404 C.s20c.14
Polar TM6 K 342 6x32 s5s6 D 70 N.s5s6.06
Van-der-waals TM6 K 342 6x32 s5s6 D 70 N.s5s6.06
Hydrophobic TM5 A 222 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 A 222 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 L 347 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 I 138 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 I 138 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic ICL1 R 65 12x48 s20c K 400 C.s20c.10
Van-der-waals ICL1 R 65 12x48 s20c K 400 C.s20c.10
Hydrophobic ICL2 I 142 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 I 142 34x51 S15 I 242 C.S15.14
Hydrophobic TM6 K 342 6x32 s5s6 G 73 N.s5s6.09
Hydrophobic TM3 I 138 3x54 S6 F 76 N.S6.01
Hydrophobic ICL2 I 142 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 I 142 34x51 s15s16 S 246 C.s15s16.04
Ionic ICL2 R 148 34x57 s5s6 D 68 N.s5s6.04
Polar ICL2 R 148 34x57 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 R 148 34x57 s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 R 148 34x57 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 I 138 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 I 138 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic ICL1 S 66 12x49 s20c Y 404 C.s20c.14
Van-der-waals ICL1 S 66 12x49 s20c Y 404 C.s20c.14
Hydrophobic H8 N 404 8x47 s5s6 V 71 N.s5s6.07
Polar ICL2 I 142 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 I 142 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 I 142 34x51 S16 Y 250 C.S16.03
Polar TM6 R 339 6x29 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 R 339 6x29 s5s6 S 75 N.s5s6.11
Ionic ICL1 R 65 12x48 s20c D 402 C.s20c.12
Polar ICL1 R 65 12x48 s20c D 402 C.s20c.12
Hydrophobic ICL1 R 65 12x48 s20c D 402 C.s20c.12
Van-der-waals ICL1 R 65 12x48 s20c D 402 C.s20c.12
Hydrophobic TM2 A 71 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 A 71 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM4 P 150 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 P 150 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM5 I 218 5x61 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 P 141 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 141 34x50 S5 Y 64 N.S5.12
Polar TM5 R 225 5x68 S5 Y 64 N.S5.12
Hydrophobic TM5 R 225 5x68 S6 F 76 N.S6.01
Van-der-waals TM5 R 225 5x68 S6 F 76 N.S6.01
Polar TM6 K 342 6x32 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 T 346 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 I 142 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 I 142 34x51 S16 A 248 C.S16.01
Polar ICL1 S 66 12x49 s8s9 T 137 N.s8s9.07
Hydrophobic ICL1 S 66 12x49 s8s9 T 137 N.s8s9.07
Van-der-waals ICL1 S 66 12x49 s8s9 T 137 N.s8s9.07
Polar TM2 N 69 2x37 s8s9 T 137 N.s8s9.07
Van-der-waals TM2 N 69 2x37 s8s9 T 137 N.s8s9.07
Hydrophobic TM3 R 134 3x50 s5s6 L 72 N.s5s6.08
Polar TM6 T 346 6x36 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 T 346 6x36 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 A 137 3x53 s5s6 L 69 N.s5s6.05
Polar H8 A 410 8x53 s20c Y 404 C.s20c.14
Van-der-waals ICL2 I 142 34x51 s15s16 L 244 C.s15s16.02
Polar TM6 T 343 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 T 343 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 T 343 6x33 s5s6 L 72 N.s5s6.08
Polar TM2 Y 73 2x41 s8s9 E 135 N.s8s9.05
Hydrophobic TM6 I 350 6x40 s5s6 L 72 N.s5s6.08
Polar TM1 E 64 1x60 s20c Y 404 C.s20c.14
Hydrophobic TM3 I 138 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 I 138 3x54 s5s6 L 72 N.s5s6.08
Polar ICL2 R 148 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 R 148 34x57 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 R 148 34x57 s5s6 R 66 N.s5s6.02
Polar ICL2 N 146 34x55 S16 Y 250 C.S16.03
Hydrophobic ICL2 N 146 34x55 S16 Y 250 C.S16.03
Van-der-waals ICL2 N 146 34x55 S16 Y 250 C.S16.03
Hydrophobic ICL2 P 141 34x50 S6 F 76 N.S6.01
Van-der-waals ICL2 P 141 34x50 S6 F 76 N.S6.01