ArrestinDb

S-arrestin - 5-HT_1A receptor complex model

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Tertiary structure confidence

Chain	pLDDT score avg
5-HT_1A	79.8
S-arrestin	80.2

Very high (>90)

Confident (90-70)

Low (70-50)

Very low (<50)

Disordered

PTM Score: 0.6

iPTM Score: 0.3

PAE mean: 23.0

GPCR - Arrestin interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Hydrophobic	H8	K	405	8x48	s5s6	D	75	N.s5s6.04
Hydrophobic	TM7	I	399	7x52	s5s6	V	78	N.s5s6.07
Hydrophobic	ICL2	P	141	34x50	s15s16	Y	254	C.s15s16.03
Hydrophobic	ICL2	N	146	34x55	S16	Y	259	C.S16.03
Hydrophobic	TM5	A	222	5x65	s5s6	L	81	N.s5s6.10
Hydrophobic	H8	N	409	8x52	s20c	R	398	C.s20c.17
Hydrophobic	TM3	R	134	3x50	s5s6	I	76	N.s5s6.05
Hydrophobic	TM5	Y	215	5x58	s5s6	I	79	N.s5s6.08
Hydrophobic	TM2	I	75	2x43	s5s6	V	78	N.s5s6.07
Hydrophobic	TM6	I	350	6x40	s5s6	I	79	N.s5s6.08
Hydrophobic	TM2	A	71	2x39	s5s6	I	76	N.s5s6.05
Hydrophobic	ICL2	V	145	34x54	S5	Y	71	N.S5.12
Hydrophobic	TM5	I	218	5x61	s5s6	I	79	N.s5s6.08
Hydrophobic	TM6	R	339	6x29	S6	D	86	N.S6.04
Hydrophobic	ICL2	P	141	34x50	S5	Y	71	N.S5.12
Hydrophobic	ICL2	V	145	34x54	s8s9	K	145	N.s8s9.09
Hydrophobic	ICL2	I	142	34x51	S15	V	251	C.S15.14
Hydrophobic	ICL2	I	142	34x51	s15s16	Y	254	C.s15s16.03
Hydrophobic	ICL2	N	146	34x55	S16	D	257	C.S16.01
Hydrophobic	TM6	L	347	6x37	s5s6	I	79	N.s5s6.08
Hydrophobic	TM6	A	331	6x21	s9s10	A	163	N.s9s10.05
Hydrophobic	TM3	I	138	3x54	S6	F	83	N.S6.01
Hydrophobic	TM6	K	332	6x22	S6	F	89	N.S6.07
Hydrophobic	TM5	R	225	5x68	s15s16	Y	254	C.s15s16.03
Hydrophobic	TM3	D	140	3x56	s15s16	S	255	C.s15s16.04
Hydrophobic	ICL2	I	142	34x51	S16	D	257	C.S16.01
Hydrophobic	TM6	I	350	6x40	s5s6	V	78	N.s5s6.07
Hydrophobic	TM6	M	335	6x25	S6	F	89	N.S6.07
Hydrophobic	ICL2	I	142	34x51	s15s16	S	256	C.s15s16.05
Hydrophobic	TM3	A	137	3x53	S6	F	83	N.S6.01
Hydrophobic	TM3	R	134	3x50	s5s6	I	79	N.s5s6.08
Hydrophobic	H8	D	406	8x49	s5s6	D	75	N.s5s6.04
Hydrophobic	TM6	K	342	6x32	s5s6	G	80	N.s5s6.09
Hydrophobic	ICL2	I	142	34x51	s15s16	S	255	C.s15s16.04
Hydrophobic	TM6	T	346	6x36	s5s6	V	78	N.s5s6.07
Hydrophobic	TM6	M	335	6x25	s9s10	E	165	N.s9s10.07
Hydrophobic	TM3	R	134	3x50	s5s6	D	77	N.s5s6.06
Hydrophobic	TM2	N	69	2x37	s5s6	Q	73	N.s5s6.02
Hydrophobic	ICL2	Y	144	34x53	S5	Y	71	N.S5.12
Hydrophobic	TM6	T	343	6x33	s5s6	I	79	N.s5s6.08
Hydrophobic	TM7	Y	400	7x53	s5s6	V	78	N.s5s6.07
Hydrophobic	ICL2	R	148	34x57	s8s9	K	145	N.s8s9.09
Hydrophobic	TM6	T	346	6x36	s5s6	I	79	N.s5s6.08
Hydrophobic	ICL2	I	142	34x51	s15s16	V	252	C.s15s16.01
Hydrophobic	TM6	T	343	6x33	s5s6	L	81	N.s5s6.10
Hydrophobic	ICL2	D	143	34x52	S16	D	257	C.S16.01
Hydrophobic	ICL2	P	141	34x50	s15s16	S	255	C.s15s16.04
Hydrophobic	TM6	K	324	6x14	S6	V	92	N.S6.10
Hydrophobic	ICL2	V	145	34x54	S16	Y	259	C.S16.03
Hydrophobic	TM3	I	138	3x54	s5s6	L	81	N.s5s6.10
Ionic	TM1	E	64	1x60	s20c	R	398	C.s20c.17
Ionic	TM6	R	339	6x29	s9s10	E	165	N.s9s10.07
Ionic	TM6	R	339	6x29	S6	D	86	N.S6.04
Ionic	TM6	K	334	6x24	s9s10	D	162	N.s9s10.04
Ionic	C-term	K	416	-	s20c	E	405	C.s20c.24
Ionic	TM3	R	134	3x50	s5s6	D	77	N.s5s6.06
Ionic	H8	K	413	8x56	s20c	E	394	C.s20c.13
Polar	ICL1	S	66	12x49	s5s6	Q	73	N.s5s6.02
Polar	H8	N	404	8x47	s5s6	I	76	N.s5s6.05
Polar	ICL2	N	146	34x55	S16	Y	259	C.S16.03
Polar	H8	N	409	8x52	s20c	R	398	C.s20c.17
Polar	ICL2	V	145	34x54	S5	Y	71	N.S5.12
Polar	TM6	R	339	6x29	s9s10	E	165	N.s9s10.07
Polar	TM6	R	339	6x29	S6	D	86	N.S6.04
Polar	ICL2	P	141	34x50	S5	Y	71	N.S5.12
Polar	TM6	K	334	6x24	s9s10	D	162	N.s9s10.04
Polar	ICL2	V	145	34x54	s8s9	K	145	N.s8s9.09
Polar	ICL2	N	146	34x55	S16	D	257	C.S16.01
Polar	TM6	K	332	6x22	S6	F	89	N.S6.07
Polar	TM3	D	140	3x56	s15s16	S	255	C.s15s16.04
Polar	TM6	N	328	6x18	S6	R	91	N.S6.09
Polar	H8	N	404	8x47	s5s6	D	75	N.s5s6.04
Polar	TM6	K	342	6x32	s5s6	G	80	N.s5s6.09
Polar	ICL2	I	142	34x51	s15s16	S	255	C.s15s16.04
Polar	TM3	R	134	3x50	s5s6	D	77	N.s5s6.06
Polar	TM2	N	69	2x37	s5s6	Q	73	N.s5s6.02
Polar	ICL2	R	148	34x57	s8s9	K	145	N.s8s9.09
Polar	ICL2	D	143	34x52	s15s16	S	255	C.s15s16.04
Polar	TM6	T	346	6x36	s5s6	I	79	N.s5s6.08
Polar	ICL2	D	143	34x52	S16	D	257	C.S16.01
Polar	ICL2	P	141	34x50	s15s16	S	255	C.s15s16.04
Van-der-waals	TM5	K	232	5x75	s17s18	V	324	C.s17s18.40
Van-der-waals	H8	K	405	8x48	s5s6	D	75	N.s5s6.04
Van-der-waals	ICL1	S	66	12x49	s5s6	Q	73	N.s5s6.02
Van-der-waals	TM7	I	399	7x52	s5s6	V	78	N.s5s6.07
Van-der-waals	H8	N	404	8x47	s5s6	I	76	N.s5s6.05
Van-der-waals	ICL2	P	141	34x50	s15s16	Y	254	C.s15s16.03
Van-der-waals	ICL2	N	146	34x55	S16	Y	259	C.S16.03
Van-der-waals	TM3	R	134	3x50	s5s6	I	76	N.s5s6.05
Van-der-waals	ICL2	V	145	34x54	S5	Y	71	N.S5.12
Van-der-waals	TM6	R	339	6x29	s9s10	E	165	N.s9s10.07
Van-der-waals	TM6	R	339	6x29	S6	D	86	N.S6.04
Van-der-waals	ICL2	P	141	34x50	S5	Y	71	N.S5.12
Van-der-waals	TM6	K	334	6x24	s9s10	D	162	N.s9s10.04
Van-der-waals	ICL2	V	145	34x54	s8s9	K	145	N.s8s9.09
Van-der-waals	ICL2	I	142	34x51	S15	V	251	C.S15.14
Van-der-waals	ICL2	I	142	34x51	s15s16	Y	254	C.s15s16.03
Van-der-waals	ICL2	N	146	34x55	S16	D	257	C.S16.01
Van-der-waals	TM3	I	138	3x54	S6	F	83	N.S6.01
Van-der-waals	TM6	K	332	6x22	S6	F	89	N.S6.07
Van-der-waals	TM5	R	225	5x68	s15s16	Y	254	C.s15s16.03
Van-der-waals	TM3	D	140	3x56	s15s16	S	255	C.s15s16.04
Van-der-waals	ICL2	I	142	34x51	S16	D	257	C.S16.01
Van-der-waals	TM3	A	137	3x53	S6	F	83	N.S6.01
Van-der-waals	H8	N	404	8x47	s5s6	D	75	N.s5s6.04
Van-der-waals	H8	D	406	8x49	s5s6	D	75	N.s5s6.04
Van-der-waals	TM6	K	342	6x32	s5s6	G	80	N.s5s6.09
Van-der-waals	ICL2	I	142	34x51	s15s16	S	255	C.s15s16.04
Van-der-waals	TM6	T	346	6x36	s5s6	V	78	N.s5s6.07
Van-der-waals	TM3	R	134	3x50	s5s6	D	77	N.s5s6.06
Van-der-waals	TM2	N	69	2x37	s5s6	Q	73	N.s5s6.02
Van-der-waals	TM5	T	229	5x72	S6	D	86	N.S6.04
Van-der-waals	ICL2	Y	144	34x53	S5	Y	71	N.S5.12
Van-der-waals	TM7	Y	400	7x53	s5s6	V	78	N.s5s6.07
Van-der-waals	ICL2	R	148	34x57	s8s9	K	145	N.s8s9.09
Van-der-waals	ICL2	D	143	34x52	s15s16	S	255	C.s15s16.04
Van-der-waals	TM6	T	346	6x36	s5s6	I	79	N.s5s6.08
Van-der-waals	ICL2	D	143	34x52	S16	D	257	C.S16.01
Van-der-waals	ICL2	P	141	34x50	s15s16	S	255	C.s15s16.04
Van-der-waals	ICL2	V	145	34x54	S16	Y	259	C.S16.03

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Main reference

S-arrestin - 5-HT1A receptor complex model Download Full