S-arrestin - 5-HT1A receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
5-HT1A 79.8
S-arrestin 80.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 23.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Van-der-waals TM5 K 232 5x75 s17s18 V 324 C.s17s18.40
Ionic TM1 E 64 1x60 s20c R 398 C.s20c.17
Hydrophobic H8 K 405 8x48 s5s6 D 75 N.s5s6.04
Van-der-waals H8 K 405 8x48 s5s6 D 75 N.s5s6.04
Polar ICL1 S 66 12x49 s5s6 Q 73 N.s5s6.02
Van-der-waals ICL1 S 66 12x49 s5s6 Q 73 N.s5s6.02
Hydrophobic TM7 I 399 7x52 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 I 399 7x52 s5s6 V 78 N.s5s6.07
Polar H8 N 404 8x47 s5s6 I 76 N.s5s6.05
Van-der-waals H8 N 404 8x47 s5s6 I 76 N.s5s6.05
Hydrophobic ICL2 P 141 34x50 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 P 141 34x50 s15s16 Y 254 C.s15s16.03
Polar ICL2 N 146 34x55 S16 Y 259 C.S16.03
Hydrophobic ICL2 N 146 34x55 S16 Y 259 C.S16.03
Van-der-waals ICL2 N 146 34x55 S16 Y 259 C.S16.03
Hydrophobic TM5 A 222 5x65 s5s6 L 81 N.s5s6.10
Polar H8 N 409 8x52 s20c R 398 C.s20c.17
Hydrophobic H8 N 409 8x52 s20c R 398 C.s20c.17
Hydrophobic TM3 R 134 3x50 s5s6 I 76 N.s5s6.05
Van-der-waals TM3 R 134 3x50 s5s6 I 76 N.s5s6.05
Hydrophobic TM5 Y 215 5x58 s5s6 I 79 N.s5s6.08
Hydrophobic TM2 I 75 2x43 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 I 350 6x40 s5s6 I 79 N.s5s6.08
Hydrophobic TM2 A 71 2x39 s5s6 I 76 N.s5s6.05
Polar ICL2 V 145 34x54 S5 Y 71 N.S5.12
Hydrophobic ICL2 V 145 34x54 S5 Y 71 N.S5.12
Van-der-waals ICL2 V 145 34x54 S5 Y 71 N.S5.12
Hydrophobic TM5 I 218 5x61 s5s6 I 79 N.s5s6.08
Ionic TM6 R 339 6x29 s9s10 E 165 N.s9s10.07
Polar TM6 R 339 6x29 s9s10 E 165 N.s9s10.07
Van-der-waals TM6 R 339 6x29 s9s10 E 165 N.s9s10.07
Ionic TM6 R 339 6x29 S6 D 86 N.S6.04
Polar TM6 R 339 6x29 S6 D 86 N.S6.04
Hydrophobic TM6 R 339 6x29 S6 D 86 N.S6.04
Van-der-waals TM6 R 339 6x29 S6 D 86 N.S6.04
Polar ICL2 P 141 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 P 141 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 141 34x50 S5 Y 71 N.S5.12
Ionic TM6 K 334 6x24 s9s10 D 162 N.s9s10.04
Polar TM6 K 334 6x24 s9s10 D 162 N.s9s10.04
Van-der-waals TM6 K 334 6x24 s9s10 D 162 N.s9s10.04
Polar ICL2 V 145 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 V 145 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 V 145 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 I 142 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 I 142 34x51 S15 V 251 C.S15.14
Hydrophobic ICL2 I 142 34x51 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 I 142 34x51 s15s16 Y 254 C.s15s16.03
Polar ICL2 N 146 34x55 S16 D 257 C.S16.01
Hydrophobic ICL2 N 146 34x55 S16 D 257 C.S16.01
Van-der-waals ICL2 N 146 34x55 S16 D 257 C.S16.01
Hydrophobic TM6 L 347 6x37 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 A 331 6x21 s9s10 A 163 N.s9s10.05
Hydrophobic TM3 I 138 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 I 138 3x54 S6 F 83 N.S6.01
Polar TM6 K 332 6x22 S6 F 89 N.S6.07
Hydrophobic TM6 K 332 6x22 S6 F 89 N.S6.07
Van-der-waals TM6 K 332 6x22 S6 F 89 N.S6.07
Ionic C-term K 416 - s20c E 405 C.s20c.24
Hydrophobic TM5 R 225 5x68 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 R 225 5x68 s15s16 Y 254 C.s15s16.03
Polar TM3 D 140 3x56 s15s16 S 255 C.s15s16.04
Hydrophobic TM3 D 140 3x56 s15s16 S 255 C.s15s16.04
Van-der-waals TM3 D 140 3x56 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 I 142 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 I 142 34x51 S16 D 257 C.S16.01
Hydrophobic TM6 I 350 6x40 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 M 335 6x25 S6 F 89 N.S6.07
Polar TM6 N 328 6x18 S6 R 91 N.S6.09
Hydrophobic ICL2 I 142 34x51 s15s16 S 256 C.s15s16.05
Hydrophobic TM3 A 137 3x53 S6 F 83 N.S6.01
Van-der-waals TM3 A 137 3x53 S6 F 83 N.S6.01
Polar H8 N 404 8x47 s5s6 D 75 N.s5s6.04
Van-der-waals H8 N 404 8x47 s5s6 D 75 N.s5s6.04
Hydrophobic TM3 R 134 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic H8 D 406 8x49 s5s6 D 75 N.s5s6.04
Van-der-waals H8 D 406 8x49 s5s6 D 75 N.s5s6.04
Polar TM6 K 342 6x32 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 K 342 6x32 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 K 342 6x32 s5s6 G 80 N.s5s6.09
Polar ICL2 I 142 34x51 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 I 142 34x51 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 I 142 34x51 s15s16 S 255 C.s15s16.04
Hydrophobic TM6 T 346 6x36 s5s6 V 78 N.s5s6.07
Van-der-waals TM6 T 346 6x36 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 M 335 6x25 s9s10 E 165 N.s9s10.07
Ionic TM3 R 134 3x50 s5s6 D 77 N.s5s6.06
Polar TM3 R 134 3x50 s5s6 D 77 N.s5s6.06
Hydrophobic TM3 R 134 3x50 s5s6 D 77 N.s5s6.06
Van-der-waals TM3 R 134 3x50 s5s6 D 77 N.s5s6.06
Polar TM2 N 69 2x37 s5s6 Q 73 N.s5s6.02
Hydrophobic TM2 N 69 2x37 s5s6 Q 73 N.s5s6.02
Van-der-waals TM2 N 69 2x37 s5s6 Q 73 N.s5s6.02
Van-der-waals TM5 T 229 5x72 S6 D 86 N.S6.04
Hydrophobic ICL2 Y 144 34x53 S5 Y 71 N.S5.12
Van-der-waals ICL2 Y 144 34x53 S5 Y 71 N.S5.12
Hydrophobic TM6 T 343 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic TM7 Y 400 7x53 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 Y 400 7x53 s5s6 V 78 N.s5s6.07
Polar ICL2 R 148 34x57 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 R 148 34x57 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 R 148 34x57 s8s9 K 145 N.s8s9.09
Polar ICL2 D 143 34x52 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 D 143 34x52 s15s16 S 255 C.s15s16.04
Ionic H8 K 413 8x56 s20c E 394 C.s20c.13
Polar TM6 T 346 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 T 346 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 T 346 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 I 142 34x51 s15s16 V 252 C.s15s16.01
Hydrophobic TM6 T 343 6x33 s5s6 L 81 N.s5s6.10
Polar ICL2 D 143 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 D 143 34x52 S16 D 257 C.S16.01
Van-der-waals ICL2 D 143 34x52 S16 D 257 C.S16.01
Polar ICL2 P 141 34x50 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 P 141 34x50 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 P 141 34x50 s15s16 S 255 C.s15s16.04
Hydrophobic TM6 K 324 6x14 S6 V 92 N.S6.10
Hydrophobic ICL2 V 145 34x54 S16 Y 259 C.S16.03
Van-der-waals ICL2 V 145 34x54 S16 Y 259 C.S16.03
Hydrophobic TM3 I 138 3x54 s5s6 L 81 N.s5s6.10