Beta-arrestin-2 - 5-HT1B receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
5-HT1B 79.6
Beta-arrestin-2 81.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 151 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 V 155 34x51 S8 L 130 N.S8.03
Van-der-waals ICL2 V 155 34x51 S8 L 130 N.S8.03
Polar ICL2 E 156 34x52 S16 Y 250 C.S16.03
Hydrophobic ICL2 E 156 34x52 S16 Y 250 C.S16.03
Van-der-waals ICL2 E 156 34x52 S16 Y 250 C.S16.03
Hydrophobic TM3 I 151 3x54 S6 F 76 N.S6.01
Ionic ICL1 R 78 12x48 s20c D 403 C.s20c.13
Hydrophobic TM5 Q 242 5x72 S6 K 78 N.S6.03
Hydrophobic TM5 Q 242 5x72 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 Q 242 5x72 s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 A 154 34x50 s5s6 G 65 N.s5s6.01
Hydrophobic TM3 I 151 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 I 151 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 R 238 5x68 S5 Y 64 N.S5.12
Hydrophobic TM6 T 315 6x36 s5s6 L 72 N.s5s6.08
Polar ICL2 A 159 34x55 s17s18 R 286 C.s17s18.11
Hydrophobic ICL2 A 159 34x55 s17s18 R 286 C.s17s18.11
Van-der-waals ICL2 A 159 34x55 s17s18 R 286 C.s17s18.11
Hydrophobic TM5 I 231 5x61 s5s6 L 72 N.s5s6.08
Van-der-waals TM5 I 231 5x61 s5s6 L 72 N.s5s6.08
Ionic ICL1 R 78 12x48 s20c D 402 C.s20c.12
Polar ICL1 R 78 12x48 s20c D 402 C.s20c.12
Hydrophobic ICL1 R 78 12x48 s20c D 402 C.s20c.12
Van-der-waals ICL1 R 78 12x48 s20c D 402 C.s20c.12
Hydrophobic TM6 L 316 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 316 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM7 S 372 7x56 s5s6 D 70 N.s5s6.06
Polar ICL1 K 79 12x49 s20c Y 404 C.s20c.14
Hydrophobic ICL1 K 79 12x49 s20c Y 404 C.s20c.14
Van-der-waals ICL1 K 79 12x49 s20c Y 404 C.s20c.14
Polar ICL2 V 155 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 V 155 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 V 155 34x51 S16 Y 250 C.S16.03
Hydrophobic TM5 A 235 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 A 235 5x65 s5s6 L 74 N.s5s6.10
Polar TM5 K 241 5x71 S6 K 78 N.S6.03
Hydrophobic TM6 K 311 6x32 s5s6 G 73 N.s5s6.09
Hydrophobic TM7 S 372 7x56 s5s6 V 71 N.s5s6.07
Polar ICL2 A 154 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 A 154 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 A 154 34x50 S5 Y 64 N.S5.12
Aromatic TM5 R 238 5x68 S6 F 76 N.S6.01
Hydrophobic TM5 R 238 5x68 S6 F 76 N.S6.01
Van-der-waals TM5 R 238 5x68 S6 F 76 N.S6.01
Polar ICL1 R 78 12x48 s20c D 401 C.s20c.11
Hydrophobic ICL1 R 78 12x48 s20c D 401 C.s20c.11
Van-der-waals ICL1 R 78 12x48 s20c D 401 C.s20c.11
Hydrophobic ICL2 V 155 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 V 155 34x51 S15 I 242 C.S15.14
Hydrophobic TM4 P 163 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 P 163 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM5 R 238 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 V 155 34x51 S9 C 141 N.S9.01
Polar ICL2 V 155 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 V 155 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 V 155 34x51 S5 Y 64 N.S5.12
Polar TM5 Q 242 5x72 s5s6 S 75 N.s5s6.11
Hydrophobic TM5 I 239 5x69 s5s6 L 74 N.s5s6.10
Ionic ICL1 K 79 12x49 s5s6 E 67 N.s5s6.03
Hydrophobic TM3 R 147 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 147 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 I 151 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 I 151 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals ICL2 S 158 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic TM5 P 244 5x74 S6 K 78 N.S6.03
Hydrophobic TM6 I 319 6x40 s5s6 V 71 N.s5s6.07
Polar TM5 Q 242 5x72 S6 R 77 N.S6.02
Hydrophobic TM5 Q 242 5x72 S6 R 77 N.S6.02
Van-der-waals TM5 Q 242 5x72 S6 R 77 N.S6.02
Polar TM6 T 315 6x36 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 T 315 6x36 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 T 315 6x36 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 A 150 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 150 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 S 158 34x54 s8s9 A 140 N.s8s9.10
Ionic ICL2 R 161 34x57 s5s6 D 68 N.s5s6.04
Polar ICL2 R 161 34x57 s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 R 161 34x57 s5s6 D 68 N.s5s6.04
Polar ICL1 R 78 12x48 s20c Y 404 C.s20c.14
Hydrophobic ICL1 R 78 12x48 s20c Y 404 C.s20c.14
Van-der-waals ICL1 R 78 12x48 s20c Y 404 C.s20c.14