Arrestin-C - 5-HT1B receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
5-HT1B 77.7
Arrestin-C 81.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 23.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 S 158 34x54 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 S 158 34x54 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 S 158 34x54 s15s16 S 242 C.s15s16.04
Hydrophobic H8 D 375 8x49 s5s6 D 62 N.s5s6.03
Van-der-waals H8 D 375 8x49 s5s6 D 62 N.s5s6.03
Hydrophobic ICL3 T 247 - S5 F 50 N.S5.03
Polar TM7 S 372 7x56 s5s6 V 66 N.s5s6.07
Hydrophobic TM7 S 372 7x56 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 S 372 7x56 s5s6 V 66 N.s5s6.07
Polar ICL3 N 245 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL3 N 245 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 N 245 - s9s10 E 152 N.s9s10.07
Hydrophobic TM5 P 244 5x74 S5 M 52 N.S5.05
Hydrophobic ICL2 V 155 34x51 s15s16 L 240 C.s15s16.02
Hydrophobic TM3 I 151 3x54 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 I 151 3x54 s5s6 L 64 N.s5s6.05
Polar ICL3 A 297 - s9s10 V 155 N.s9s10.10
Hydrophobic ICL3 A 297 - s9s10 V 155 N.s9s10.10
Van-der-waals ICL3 A 297 - s9s10 V 155 N.s9s10.10
Ionic ICL1 K 79 12x49 s5s6 D 62 N.s5s6.03
Polar ICL3 L 298 - s9s10 T 154 N.s9s10.09
Hydrophobic ICL3 L 298 - s9s10 T 154 N.s9s10.09
Van-der-waals ICL3 L 298 - s9s10 T 154 N.s9s10.09
Hydrophobic TM2 T 82 2x37 s8s9 K 135 N.s8s9.09
Polar TM5 Q 242 5x72 s5s6 T 70 N.s5s6.11
Ionic ICL3 D 296 - s4s5 R 47 N.s4s5.08
Polar ICL3 D 296 - s4s5 R 47 N.s4s5.08
Hydrophobic ICL3 D 296 - s4s5 R 47 N.s4s5.08
Van-der-waals ICL3 D 296 - s4s5 R 47 N.s4s5.08
Hydrophobic TM3 R 147 3x50 s5s6 I 67 N.s5s6.08
Polar ICL3 K 302 - s9s10 T 154 N.s9s10.09
Hydrophobic ICL3 K 302 - s9s10 T 154 N.s9s10.09
Van-der-waals ICL3 K 302 - s9s10 T 154 N.s9s10.09
Hydrophobic ICL2 A 159 34x55 s15s16 L 243 C.s15s16.05
Van-der-waals ICL2 A 159 34x55 s15s16 L 243 C.s15s16.05
Polar ICL3 S 295 - s9s10 E 149 N.s9s10.01
Hydrophobic ICL3 S 295 - s9s10 E 149 N.s9s10.01
Van-der-waals ICL3 S 295 - s9s10 E 149 N.s9s10.01
Van-der-waals ICL3 K 301 - s9s10 S 156 N.s9s10.11
Polar ICL3 R 246 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 R 246 - s9s10 E 152 N.s9s10.07
Hydrophobic TM5 R 238 5x68 S6 F 71 N.S6.01
Van-der-waals TM5 R 238 5x68 S6 F 71 N.S6.01
Hydrophobic TM6 M 305 6x26 s9s10 T 154 N.s9s10.09
Van-der-waals TM6 M 305 6x26 s9s10 T 154 N.s9s10.09
Polar TM6 R 308 6x29 s5s6 T 70 N.s5s6.11
Polar ICL3 R 250 - s4s5 Y 43 N.s4s5.04
Aromatic ICL3 R 250 - s4s5 Y 43 N.s4s5.04
Hydrophobic ICL3 R 250 - s4s5 Y 43 N.s4s5.04
Van-der-waals ICL3 R 250 - s4s5 Y 43 N.s4s5.04
Hydrophobic TM3 R 147 3x50 s5s6 V 66 N.s5s6.07
Polar ICL3 R 250 - s4s5 R 47 N.s4s5.08
Hydrophobic ICL3 R 250 - s4s5 R 47 N.s4s5.08
Van-der-waals ICL3 R 250 - s4s5 R 47 N.s4s5.08
Polar ICL3 R 246 - s9s10 N 150 N.s9s10.02
Hydrophobic ICL3 R 246 - s9s10 N 150 N.s9s10.02
Van-der-waals ICL3 R 246 - s9s10 N 150 N.s9s10.02
Polar ICL3 G 248 - s9s10 N 150 N.s9s10.02
Hydrophobic ICL3 G 248 - s9s10 N 150 N.s9s10.02
Van-der-waals ICL3 G 248 - s9s10 N 150 N.s9s10.02
Hydrophobic ICL2 A 154 34x50 S6 F 71 N.S6.01
Van-der-waals ICL2 A 154 34x50 S6 F 71 N.S6.01
Hydrophobic ICL3 G 248 - S5 K 48 N.S5.01
Van-der-waals ICL3 G 248 - S5 K 48 N.S5.01
Hydrophobic TM6 L 316 6x37 s5s6 I 67 N.s5s6.08
Hydrophobic H8 N 373 8x47 s5s6 V 66 N.s5s6.07
Van-der-waals H8 N 373 8x47 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 V 155 34x51 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 V 155 34x51 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL3 G 248 - S9 A 148 N.S9.12
Van-der-waals ICL3 G 248 - S9 A 148 N.S9.12
Polar TM6 T 315 6x36 s5s6 V 66 N.s5s6.07
Hydrophobic TM6 T 315 6x36 s5s6 V 66 N.s5s6.07
Van-der-waals TM6 T 315 6x36 s5s6 V 66 N.s5s6.07
Polar ICL3 K 301 - s9s10 T 154 N.s9s10.09
Hydrophobic ICL3 K 301 - s9s10 T 154 N.s9s10.09
Van-der-waals ICL3 K 301 - s9s10 T 154 N.s9s10.09
Hydrophobic TM6 K 311 6x32 s5s6 G 68 N.s5s6.09
Hydrophobic TM5 T 243 5x73 s9s10 E 152 N.s9s10.07
Van-der-waals TM5 T 243 5x73 s9s10 E 152 N.s9s10.07
Hydrophobic ICL3 A 297 - s9s10 T 154 N.s9s10.09
Van-der-waals ICL3 A 297 - s9s10 T 154 N.s9s10.09
Polar ICL2 S 158 34x54 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 S 158 34x54 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 S 158 34x54 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 I 239 5x69 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 S 158 34x54 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 S 158 34x54 s5s6 R 61 N.s5s6.02
Hydrophobic ICL3 K 249 - S5 L 49 N.S5.02
Ionic ICL3 E 300 - s9s10 R 158 N.s9s10.13
Polar ICL3 E 300 - s9s10 R 158 N.s9s10.13
Hydrophobic ICL3 E 300 - s9s10 R 158 N.s9s10.13
Polar ICL3 S 295 - s9s10 E 153 N.s9s10.08
Hydrophobic ICL3 S 295 - s9s10 E 153 N.s9s10.08
Van-der-waals ICL3 S 295 - s9s10 E 153 N.s9s10.08
Hydrophobic ICL3 K 249 - S9 A 148 N.S9.12
Van-der-waals ICL3 K 249 - S9 A 148 N.S9.12
Polar ICL3 R 250 - s4s5 L 44 N.s4s5.05
Van-der-waals ICL3 R 250 - s4s5 L 44 N.s4s5.05
Hydrophobic TM6 T 315 6x36 s5s6 I 67 N.s5s6.08
Polar ICL3 T 247 - S5 K 48 N.S5.01
Van-der-waals ICL3 T 247 - S5 K 48 N.S5.01
Hydrophobic ICL3 L 298 - s9s10 E 153 N.s9s10.08
Van-der-waals ICL3 L 298 - s9s10 E 153 N.s9s10.08
Polar ICL3 E 300 - s9s10 K 157 N.s9s10.12
Van-der-waals ICL3 E 300 - s9s10 K 157 N.s9s10.12
Polar ICL3 K 301 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 K 301 - s9s10 E 152 N.s9s10.07
Polar ICL3 G 248 - s9s10 E 149 N.s9s10.01
Hydrophobic ICL3 G 248 - s9s10 E 149 N.s9s10.01
Van-der-waals ICL3 G 248 - s9s10 E 149 N.s9s10.01
Hydrophobic TM5 T 243 5x73 s9s10 T 154 N.s9s10.09
Van-der-waals TM5 T 243 5x73 s9s10 T 154 N.s9s10.09
Polar ICL3 K 249 - s9s10 N 150 N.s9s10.02
Hydrophobic ICL3 K 249 - s9s10 N 150 N.s9s10.02
Van-der-waals ICL3 K 249 - s9s10 N 150 N.s9s10.02
Ionic ICL3 R 250 - s9s10 E 149 N.s9s10.01
Polar ICL3 R 250 - s9s10 E 149 N.s9s10.01
Hydrophobic ICL3 R 250 - s9s10 E 149 N.s9s10.01
Van-der-waals ICL3 R 250 - s9s10 E 149 N.s9s10.01
Hydrophobic TM5 I 231 5x61 s5s6 I 67 N.s5s6.08
Polar TM6 A 312 6x33 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 A 312 6x33 s5s6 I 67 N.s5s6.08
Polar TM5 P 244 5x74 s9s10 E 152 N.s9s10.07
Hydrophobic TM5 P 244 5x74 s9s10 E 152 N.s9s10.07
Van-der-waals TM5 P 244 5x74 s9s10 E 152 N.s9s10.07
Hydrophobic ICL3 G 248 - S5 F 50 N.S5.03
Van-der-waals ICL3 G 248 - S5 F 50 N.S5.03
Polar ICL3 K 301 - s9s10 P 151 N.s9s10.03
Hydrophobic ICL2 A 154 34x50 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 A 154 34x50 s15s16 Y 241 C.s15s16.03
Polar ICL1 K 79 12x49 s8s9 P 130 N.s8s9.04
Hydrophobic ICL3 G 248 - s9s10 P 151 N.s9s10.03
Van-der-waals ICL3 G 248 - s9s10 P 151 N.s9s10.03
Hydrophobic TM5 A 235 5x65 s5s6 L 69 N.s5s6.10
Hydrophobic ICL3 K 249 - s9s10 V 155 N.s9s10.10
Ionic ICL2 R 161 34x57 s5s6 D 63 N.s5s6.04
Polar ICL2 R 161 34x57 s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 R 161 34x57 s5s6 D 63 N.s5s6.04
Van-der-waals ICL2 R 161 34x57 s5s6 D 63 N.s5s6.04
Hydrophobic TM5 P 244 5x74 s9s10 P 151 N.s9s10.03
Van-der-waals TM5 P 244 5x74 s9s10 P 151 N.s9s10.03
Polar ICL2 A 154 34x50 s5s6 R 61 N.s5s6.02
Polar ICL3 T 247 - s9s10 N 150 N.s9s10.02
Hydrophobic ICL3 T 247 - s9s10 N 150 N.s9s10.02
Van-der-waals ICL3 T 247 - s9s10 N 150 N.s9s10.02
Hydrophobic TM6 L 304 6x25 s9s10 K 157 N.s9s10.12
Hydrophobic H8 N 373 8x47 s5s6 D 62 N.s5s6.03
Hydrophobic ICL3 R 246 - S5 M 52 N.S5.05
Van-der-waals ICL3 R 246 - S5 M 52 N.S5.05
Polar ICL3 A 297 - s9s10 S 156 N.s9s10.11
Hydrophobic ICL3 A 297 - s9s10 S 156 N.s9s10.11
Van-der-waals ICL3 A 297 - s9s10 S 156 N.s9s10.11
Hydrophobic ICL2 V 155 34x51 s17s18 E 310 C.s17s18.39
Polar ICL3 K 249 - S5 F 50 N.S5.03
Hydrophobic ICL3 K 249 - S5 F 50 N.S5.03
Van-der-waals ICL3 K 249 - S5 F 50 N.S5.03
Polar ICL3 R 250 - S9 C 147 N.S9.11
Hydrophobic ICL3 R 250 - S9 C 147 N.S9.11
Van-der-waals ICL3 R 250 - S9 C 147 N.S9.11
Hydrophobic ICL3 K 249 - s9s10 E 153 N.s9s10.08
Van-der-waals ICL3 K 249 - s9s10 E 153 N.s9s10.08
Hydrophobic TM2 A 84 2x39 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 A 84 2x39 s5s6 D 63 N.s5s6.04
Hydrophobic ICL3 R 250 - s9s10 V 155 N.s9s10.10
Polar ICL3 K 249 - S9 F 146 N.S9.10
Aromatic ICL3 K 249 - S9 F 146 N.S9.10
Hydrophobic ICL3 K 249 - S9 F 146 N.S9.10
Van-der-waals ICL3 K 249 - S9 F 146 N.S9.10
Polar ICL3 T 247 - s6h1 E 86 N.s6h1.03
Hydrophobic ICL3 K 301 - s9s10 V 155 N.s9s10.10
Van-der-waals ICL3 K 301 - s9s10 V 155 N.s9s10.10
Polar ICL3 R 246 - S6 T 79 N.S6.09
Hydrophobic ICL3 R 246 - S6 T 79 N.S6.09
Van-der-waals ICL3 R 246 - S6 T 79 N.S6.09
Hydrophobic ICL3 R 250 - S9 A 148 N.S9.12
Van-der-waals ICL3 R 250 - S9 A 148 N.S9.12
Polar ICL3 K 249 - s9s10 P 151 N.s9s10.03
Hydrophobic ICL3 K 249 - s9s10 P 151 N.s9s10.03
Van-der-waals ICL3 K 249 - s9s10 P 151 N.s9s10.03
Polar ICL3 R 250 - s9s10 E 153 N.s9s10.08
Hydrophobic ICL3 R 250 - s9s10 E 153 N.s9s10.08
Van-der-waals ICL3 R 250 - s9s10 E 153 N.s9s10.08
Ionic ICL1 R 78 12x48 s8s9 E 131 N.s8s9.05
Polar ICL1 R 78 12x48 s8s9 E 131 N.s8s9.05
Hydrophobic ICL1 R 78 12x48 s8s9 E 131 N.s8s9.05
Van-der-waals ICL1 R 78 12x48 s8s9 E 131 N.s8s9.05
Polar ICL3 R 246 - s9s10 P 151 N.s9s10.03
Hydrophobic ICL3 R 246 - s9s10 P 151 N.s9s10.03
Van-der-waals ICL3 R 246 - s9s10 P 151 N.s9s10.03
Polar TM5 Q 242 5x72 S6 R 72 N.S6.02
Hydrophobic TM5 Q 242 5x72 S6 R 72 N.S6.02
Polar TM6 K 311 6x32 s5s6 E 65 N.s5s6.06
Van-der-waals TM6 K 311 6x32 s5s6 E 65 N.s5s6.06
Polar ICL3 K 301 - s9s10 E 153 N.s9s10.08
Polar ICL3 A 297 - s9s10 D 159 N.s9s10.14
Hydrophobic ICL3 A 297 - s9s10 D 159 N.s9s10.14
Van-der-waals ICL3 A 297 - s9s10 D 159 N.s9s10.14
Hydrophobic TM3 I 151 3x54 s5s6 L 69 N.s5s6.10
Polar ICL3 E 300 - s9s10 S 156 N.s9s10.11
Hydrophobic ICL3 E 300 - s9s10 S 156 N.s9s10.11
Van-der-waals ICL3 E 300 - s9s10 S 156 N.s9s10.11
Hydrophobic TM3 I 151 3x54 s5s6 I 67 N.s5s6.08
Hydrophobic ICL3 T 247 - s9s10 P 151 N.s9s10.03
Van-der-waals ICL3 T 247 - s9s10 P 151 N.s9s10.03
Polar TM6 K 311 6x32 s5s6 V 66 N.s5s6.07
Polar ICL3 K 249 - s9s10 E 149 N.s9s10.01
Hydrophobic ICL3 K 249 - s9s10 E 149 N.s9s10.01
Van-der-waals ICL3 K 249 - s9s10 E 149 N.s9s10.01