S-arrestin - 5-HT1B receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
5-HT1B 78.2
S-arrestin 80.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 V 155 34x51 S8 L 136 N.S8.03
Van-der-waals ICL2 V 155 34x51 S8 L 136 N.S8.03
Polar ICL2 V 155 34x51 S5 Y 71 N.S5.12
Hydrophobic ICL2 V 155 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 V 155 34x51 S5 Y 71 N.S5.12
Hydrophobic TM3 I 151 3x54 s5s6 I 76 N.s5s6.05
Hydrophobic ICL2 S 158 34x54 s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 S 158 34x54 s8s9 D 142 N.s8s9.06
Hydrophobic TM6 L 316 6x37 s5s6 I 79 N.s5s6.08
Ionic H8 K 382 8x56 s20c E 405 C.s20c.24
Polar H8 K 382 8x56 s20c E 405 C.s20c.24
Hydrophobic H8 K 382 8x56 s20c E 405 C.s20c.24
Van-der-waals H8 K 382 8x56 s20c E 405 C.s20c.24
Polar ICL2 A 154 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 A 154 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 A 154 34x50 S5 Y 71 N.S5.12
Hydrophobic TM5 I 239 5x69 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 S 158 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 S 158 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic TM6 A 312 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 A 312 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 A 312 6x33 s5s6 L 81 N.s5s6.10
Polar TM5 K 241 5x71 S6 R 85 N.S6.03
Hydrophobic TM5 K 241 5x71 S6 R 85 N.S6.03
Van-der-waals TM5 K 241 5x71 S6 R 85 N.S6.03
Hydrophobic TM5 R 238 5x68 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 R 238 5x68 s15s16 Y 254 C.s15s16.03
Polar H8 N 373 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic H8 N 373 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 N 373 8x47 s5s6 D 77 N.s5s6.06
Ionic ICL1 R 78 12x48 s20c E 394 C.s20c.13
Polar ICL1 R 78 12x48 s20c E 394 C.s20c.13
Hydrophobic ICL1 R 78 12x48 s20c E 394 C.s20c.13
Van-der-waals ICL1 R 78 12x48 s20c E 394 C.s20c.13
Polar ICL2 A 159 34x55 s8s9 D 142 N.s8s9.06
Hydrophobic ICL2 A 159 34x55 s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 A 159 34x55 s8s9 D 142 N.s8s9.06
Hydrophobic TM3 A 150 3x53 s5s6 I 76 N.s5s6.05
Polar TM3 R 147 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 R 147 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 147 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 V 155 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 V 155 34x51 S16 Y 259 C.S16.03
Polar TM6 K 311 6x32 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 K 311 6x32 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 K 311 6x32 s5s6 G 80 N.s5s6.09
Aromatic ICL3 R 246 - s7s8 Y 129 N.s7s8.05
Van-der-waals ICL3 R 246 - s7s8 Y 129 N.s7s8.05
Hydrophobic TM5 A 235 5x65 s5s6 L 81 N.s5s6.10
Polar ICL2 A 154 34x50 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 A 154 34x50 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 A 154 34x50 s8s9 K 145 N.s8s9.09
Polar ICL2 R 161 34x57 s5s6 Q 73 N.s5s6.02
Van-der-waals ICL2 R 161 34x57 s5s6 Q 73 N.s5s6.02
Polar TM7 S 372 7x56 s5s6 G 80 N.s5s6.09
Polar TM6 R 308 6x29 S6 R 84 N.S6.02
Hydrophobic ICL2 R 161 34x57 s8s9 K 145 N.s8s9.09
Polar TM5 Q 242 5x72 S6 R 85 N.S6.03
Hydrophobic TM5 Q 242 5x72 S6 R 85 N.S6.03
Van-der-waals TM5 Q 242 5x72 S6 R 85 N.S6.03
Hydrophobic TM5 I 231 5x61 s5s6 I 79 N.s5s6.08
Van-der-waals TM5 I 231 5x61 s5s6 I 79 N.s5s6.08
Polar H8 E 374 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic TM3 I 151 3x54 S6 F 83 N.S6.01
Polar ICL2 Y 157 34x53 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 Y 157 34x53 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 Y 157 34x53 s8s9 K 145 N.s8s9.09
Polar TM5 Q 242 5x72 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 Q 242 5x72 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 Q 242 5x72 s15s16 Y 254 C.s15s16.03
Hydrophobic TM3 I 151 3x54 s5s6 I 79 N.s5s6.08
Polar TM5 Q 242 5x72 S6 R 84 N.S6.02
Van-der-waals TM5 Q 242 5x72 S6 R 84 N.S6.02
Hydrophobic TM5 R 238 5x68 S5 Y 71 N.S5.12
Polar ICL2 E 156 34x52 S16 Y 259 C.S16.03
Hydrophobic ICL2 E 156 34x52 S16 Y 259 C.S16.03
Van-der-waals ICL2 E 156 34x52 S16 Y 259 C.S16.03
Hydrophobic ICL2 V 155 34x51 S9 C 147 N.S9.01
Aromatic TM5 R 238 5x68 S6 F 83 N.S6.01
Hydrophobic TM5 R 238 5x68 S6 F 83 N.S6.01
Van-der-waals TM5 R 238 5x68 S6 F 83 N.S6.01
Polar ICL3 K 301 - S6 D 86 N.S6.04
Polar TM6 T 315 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 T 315 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 T 315 6x36 s5s6 I 79 N.s5s6.08