Beta-arrestin-2 - 5-HT1D receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
5-HT1D 82.0
Beta-arrestin-2 79.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 17.1


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 140 3x54 S6 F 76 N.S6.01
Polar ICL2 S 147 34x54 S16 Y 250 C.S16.03
Van-der-waals ICL2 S 147 34x54 S16 Y 250 C.S16.03
Hydrophobic TM3 I 140 3x54 s5s6 L 72 N.s5s6.08
Polar TM4 A 152 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 A 152 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 A 152 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM5 I 228 5x69 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 I 228 5x69 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 L 303 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 303 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic TM7 F 359 7x56 s5s6 V 71 N.s5s6.07
Hydrophobic ICL3 Y 235 - S6 K 78 N.S6.03
Van-der-waals ICL3 Y 235 - S6 K 78 N.S6.03
Polar ICL1 K 68 12x49 s8s9 T 137 N.s8s9.07
Hydrophobic ICL1 K 68 12x49 s8s9 T 137 N.s8s9.07
Van-der-waals ICL1 K 68 12x49 s8s9 T 137 N.s8s9.07
Polar TM6 A 299 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 A 299 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 A 299 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 R 136 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 136 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM2 P 72 2x38 s8s9 E 135 N.s8s9.05
Van-der-waals TM2 P 72 2x38 s8s9 E 135 N.s8s9.05
Polar ICL2 A 143 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 A 143 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 A 143 34x50 S5 Y 64 N.S5.12
Aromatic TM5 R 227 5x68 S6 F 76 N.S6.01
Hydrophobic TM5 R 227 5x68 S6 F 76 N.S6.01
Van-der-waals TM5 R 227 5x68 S6 F 76 N.S6.01
Hydrophobic TM2 A 73 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM6 K 298 6x32 s5s6 G 73 N.s5s6.09
Hydrophobic TM4 T 151 4x38 s8s9 E 135 N.s8s9.05
Polar H8 E 362 8x49 s8s9 T 137 N.s8s9.07
Van-der-waals H8 E 362 8x49 s8s9 T 137 N.s8s9.07
Hydrophobic TM3 A 139 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 139 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 L 144 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 L 144 34x51 S16 A 248 C.S16.01
Polar ICL2 L 144 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 L 144 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 L 144 34x51 S5 Y 64 N.S5.12
Hydrophobic TM6 I 302 6x36 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 I 302 6x36 s5s6 V 71 N.s5s6.07
Aromatic ICL2 K 148 34x55 S16 Y 250 C.S16.03
Hydrophobic ICL2 K 148 34x55 S16 Y 250 C.S16.03
Van-der-waals ICL2 K 148 34x55 S16 Y 250 C.S16.03
Polar ICL2 K 148 34x55 S16 Q 249 C.S16.02
Ionic ICL1 K 68 12x49 s5s6 E 67 N.s5s6.03
Polar ICL1 K 68 12x49 s5s6 E 67 N.s5s6.03
Hydrophobic ICL1 K 68 12x49 s5s6 E 67 N.s5s6.03
Van-der-waals ICL1 K 68 12x49 s5s6 E 67 N.s5s6.03
Hydrophobic ICL2 L 144 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 L 144 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 I 140 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 I 140 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic H8 N 360 8x47 s5s6 V 71 N.s5s6.07
Polar ICL2 L 144 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 144 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 144 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL3 Y 235 - S6 D 79 N.S6.04
Van-der-waals ICL3 Y 235 - S6 D 79 N.S6.04
Polar TM6 R 295 6x29 s5s6 S 75 N.s5s6.11
Polar TM5 P 232 5x73 S6 K 78 N.S6.03
Hydrophobic TM5 P 232 5x73 S6 K 78 N.S6.03
Van-der-waals TM5 P 232 5x73 S6 K 78 N.S6.03
Hydrophobic TM5 P 232 5x73 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 P 232 5x73 s15s16 L 244 C.s15s16.02
Hydrophobic H8 E 362 8x49 s5s6 E 67 N.s5s6.03
Van-der-waals H8 E 362 8x49 s5s6 E 67 N.s5s6.03
Van-der-waals H8 K 369 8x56 s20c Y 404 C.s20c.14
Hydrophobic ICL3 L 234 - s17s18 V 315 C.s17s18.40
Van-der-waals ICL3 L 234 - s17s18 V 315 C.s17s18.40
Hydrophobic TM5 I 220 5x61 s5s6 L 72 N.s5s6.08
Van-der-waals TM5 I 220 5x61 s5s6 L 72 N.s5s6.08
Hydrophobic ICL1 R 67 12x48 s20c D 402 C.s20c.12
Hydrophobic ICL3 L 234 - s17s18 E 314 C.s17s18.39
Van-der-waals ICL3 L 234 - s17s18 E 314 C.s17s18.39
Polar ICL3 R 288 - S6 D 79 N.S6.04
Hydrophobic ICL2 L 144 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 144 34x51 S15 I 242 C.S15.14
Polar TM6 R 295 6x29 S6 R 77 N.S6.02
Polar ICL2 R 150 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 R 150 34x57 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 R 150 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic TM5 A 224 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 A 224 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic ICL1 R 67 12x48 s20c K 400 C.s20c.10
Van-der-waals ICL1 R 67 12x48 s20c K 400 C.s20c.10
Hydrophobic ICL3 L 234 - s15s16 L 244 C.s15s16.02
Van-der-waals ICL3 L 234 - s15s16 L 244 C.s15s16.02
Hydrophobic TM3 I 140 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic TM2 T 71 2x37 s8s9 T 137 N.s8s9.07
Hydrophobic TM5 R 227 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic ICL3 L 234 - S6 K 78 N.S6.03
Van-der-waals ICL3 L 234 - S6 K 78 N.S6.03
Van-der-waals TM2 T 71 2x37 s8s9 E 135 N.s8s9.05
Ionic ICL2 R 150 34x57 s5s6 D 68 N.s5s6.04
Polar ICL2 R 150 34x57 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 R 150 34x57 s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 R 150 34x57 s5s6 D 68 N.s5s6.04
Hydrophobic TM6 I 302 6x36 s5s6 L 72 N.s5s6.08
Polar ICL2 S 147 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 S 147 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL3 L 234 - s17s18 N 312 C.s17s18.37
Van-der-waals ICL3 L 234 - s17s18 N 312 C.s17s18.37