Arrestin-C - 5-HT1D receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
5-HT1D 79.6
Arrestin-C 80.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 23.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 A 224 5x65 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 A 224 5x65 s5s6 L 69 N.s5s6.10
Polar ICL2 A 143 34x50 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 A 143 34x50 s15s16 S 242 C.s15s16.04
Polar ICL2 A 143 34x50 S5 Y 59 N.S5.12
Hydrophobic ICL2 A 143 34x50 S5 Y 59 N.S5.12
Hydrophobic TM3 I 140 3x54 S6 F 71 N.S6.01
Hydrophobic ICL2 R 150 34x57 s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 R 150 34x57 s8s9 K 135 N.s8s9.09
Hydrophobic TM5 P 232 5x73 S6 K 73 N.S6.03
Van-der-waals TM5 P 232 5x73 S6 K 73 N.S6.03
Ionic TM6 R 295 6x29 S6 D 74 N.S6.04
Polar TM6 R 295 6x29 S6 D 74 N.S6.04
Van-der-waals TM6 R 295 6x29 S6 D 74 N.S6.04
Hydrophobic C-term S 377 - s20c S 388 C.s20c.22
Van-der-waals C-term S 377 - s20c S 388 C.s20c.22
Hydrophobic ICL2 K 148 34x55 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 K 148 34x55 s8s9 A 133 N.s8s9.07
Hydrophobic ICL3 L 234 - s17s18 E 310 C.s17s18.39
Van-der-waals ICL3 L 234 - s17s18 E 310 C.s17s18.39
Polar TM6 R 295 6x29 S6 R 72 N.S6.02
Van-der-waals TM6 R 295 6x29 S6 R 72 N.S6.02
Hydrophobic TM6 I 302 6x36 s5s6 V 66 N.s5s6.07
Van-der-waals TM6 I 302 6x36 s5s6 V 66 N.s5s6.07
Hydrophobic TM6 L 303 6x37 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 R 136 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 136 3x50 s5s6 I 67 N.s5s6.08
Ionic H8 K 369 8x56 s20c E 383 C.s20c.17
Hydrophobic ICL3 Y 235 - S6 K 73 N.S6.03
Hydrophobic TM7 F 359 7x56 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 F 359 7x56 s5s6 V 66 N.s5s6.07
Polar ICL2 S 147 34x54 s8s9 A 133 N.s8s9.07
Hydrophobic ICL2 S 147 34x54 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 S 147 34x54 s8s9 A 133 N.s8s9.07
Hydrophobic ICL3 L 234 - s17s18 L 311 C.s17s18.40
Van-der-waals ICL3 L 234 - s17s18 L 311 C.s17s18.40
Polar ICL3 E 287 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL3 E 287 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 E 287 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL2 L 144 34x51 S16 D 244 C.S16.01
Van-der-waals ICL2 L 144 34x51 S16 D 244 C.S16.01
Hydrophobic TM3 I 140 3x54 s5s6 L 64 N.s5s6.05
Hydrophobic TM5 R 227 5x68 S6 F 71 N.S6.01
Van-der-waals TM5 R 227 5x68 S6 F 71 N.S6.01
Polar H8 E 362 8x49 s5s6 D 62 N.s5s6.03
Hydrophobic H8 E 362 8x49 s5s6 D 62 N.s5s6.03
Van-der-waals H8 E 362 8x49 s5s6 D 62 N.s5s6.03
Polar ICL2 L 144 34x51 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 L 144 34x51 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 L 144 34x51 s15s16 S 242 C.s15s16.04
Hydrophobic TM2 T 71 2x37 s5s6 R 61 N.s5s6.02
Van-der-waals TM2 T 71 2x37 s5s6 R 61 N.s5s6.02
Aromatic ICL3 F 239 - S6 Y 76 N.S6.06
Hydrophobic ICL3 F 239 - S6 Y 76 N.S6.06
Van-der-waals ICL3 F 239 - S6 Y 76 N.S6.06
Ionic TM6 R 290 6x24 s9s10 E 152 N.s9s10.07
Polar TM6 R 290 6x24 s9s10 E 152 N.s9s10.07
Hydrophobic TM6 R 290 6x24 s9s10 E 152 N.s9s10.07
Van-der-waals TM6 R 290 6x24 s9s10 E 152 N.s9s10.07
Hydrophobic TM6 I 302 6x36 s5s6 I 67 N.s5s6.08
Hydrophobic TM7 F 359 7x56 s5s6 E 65 N.s5s6.06
Van-der-waals TM7 F 359 7x56 s5s6 E 65 N.s5s6.06
Hydrophobic ICL3 L 234 - s17s18 D 308 C.s17s18.37
Van-der-waals ICL3 L 234 - s17s18 D 308 C.s17s18.37
Hydrophobic H8 N 360 8x47 s5s6 V 66 N.s5s6.07
Van-der-waals H8 N 360 8x47 s5s6 V 66 N.s5s6.07
Hydrophobic ICL3 Y 235 - s17s18 L 311 C.s17s18.40
Hydrophobic ICL3 F 239 - s7s8 V 117 N.s7s8.03
Van-der-waals ICL3 F 239 - s7s8 V 117 N.s7s8.03
Hydrophobic TM3 I 140 3x54 s5s6 L 69 N.s5s6.10
Polar H8 N 360 8x47 s5s6 D 63 N.s5s6.04
Hydrophobic H8 N 360 8x47 s5s6 D 63 N.s5s6.04
Van-der-waals H8 N 360 8x47 s5s6 D 63 N.s5s6.04
Polar ICL2 S 147 34x54 S16 D 244 C.S16.01
Van-der-waals ICL2 S 147 34x54 S16 D 244 C.S16.01
Hydrophobic ICL2 L 144 34x51 s15s16 L 243 C.s15s16.05
Van-der-waals ICL2 L 144 34x51 s15s16 L 243 C.s15s16.05
Ionic ICL2 K 148 34x55 S16 D 244 C.S16.01
Polar ICL2 K 148 34x55 S16 D 244 C.S16.01
Hydrophobic ICL2 K 148 34x55 S16 D 244 C.S16.01
Van-der-waals ICL2 K 148 34x55 S16 D 244 C.S16.01
Hydrophobic C-term K 375 - s20c G 387 C.s20c.21
Van-der-waals C-term K 375 - s20c G 387 C.s20c.21
Hydrophobic TM3 R 136 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 136 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic TM6 I 302 6x36 s5s6 G 68 N.s5s6.09
Van-der-waals TM6 I 302 6x36 s5s6 G 68 N.s5s6.09
Hydrophobic TM5 P 231 5x72 S6 K 73 N.S6.03
Ionic ICL2 R 150 34x57 s5s6 D 63 N.s5s6.04
Polar ICL2 R 150 34x57 s5s6 D 63 N.s5s6.04
Van-der-waals ICL2 R 150 34x57 s5s6 D 63 N.s5s6.04
Hydrophobic TM5 I 228 5x69 s5s6 L 69 N.s5s6.10
Ionic H8 E 361 8x48 s9s10 K 157 N.s9s10.12
Polar H8 E 361 8x48 s9s10 K 157 N.s9s10.12
Van-der-waals H8 E 361 8x48 s9s10 K 157 N.s9s10.12
Polar H8 E 362 8x49 s5s6 D 63 N.s5s6.04
Hydrophobic H8 E 362 8x49 s5s6 D 63 N.s5s6.04
Van-der-waals H8 E 362 8x49 s5s6 D 63 N.s5s6.04
Hydrophobic H8 N 360 8x47 s5s6 E 65 N.s5s6.06
Hydrophobic TM6 K 298 6x32 s5s6 G 68 N.s5s6.09
Hydrophobic TM3 I 140 3x54 s5s6 I 67 N.s5s6.08
Polar ICL2 S 147 34x54 s8s9 G 134 N.s8s9.08
Hydrophobic ICL2 S 147 34x54 s8s9 G 134 N.s8s9.08
Polar ICL3 D 283 - S6 T 79 N.S6.09
Van-der-waals ICL3 D 283 - S6 T 79 N.S6.09
Hydrophobic TM5 R 227 5x68 s15s16 Y 241 C.s15s16.03
Polar ICL3 D 283 - S6 Q 78 N.S6.08
Hydrophobic ICL3 D 283 - S6 Q 78 N.S6.08
Van-der-waals ICL3 D 283 - S6 Q 78 N.S6.08
Ionic H8 R 364 8x51 s5s6 E 65 N.s5s6.06
Polar H8 E 361 8x48 s5s6 E 65 N.s5s6.06
Hydrophobic H8 E 361 8x48 s5s6 E 65 N.s5s6.06
Van-der-waals H8 E 361 8x48 s5s6 E 65 N.s5s6.06
Hydrophobic TM5 I 220 5x61 s5s6 I 67 N.s5s6.08
Hydrophobic TM7 Y 356 7x53 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 Y 356 7x53 s5s6 V 66 N.s5s6.07