S-arrestin - 5-HT1D receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
5-HT1D 82.2
S-arrestin 82.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM5 R 227 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 R 227 5x68 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 R 227 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL3 F 239 - s7s8 Y 129 N.s7s8.05
Polar ICL3 Y 235 - S6 L 87 N.S6.05
Hydrophobic ICL3 Y 235 - S6 L 87 N.S6.05
Van-der-waals ICL3 Y 235 - S6 L 87 N.S6.05
Polar ICL2 A 143 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 A 143 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 A 143 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 L 144 34x51 S15 V 251 C.S15.14
Polar H8 E 361 8x48 s5s6 D 77 N.s5s6.06
Polar ICL3 Y 235 - S6 D 86 N.S6.04
Van-der-waals ICL3 Y 235 - S6 D 86 N.S6.04
Polar ICL3 R 288 - S6 L 87 N.S6.05
Hydrophobic ICL3 R 288 - S6 L 87 N.S6.05
Van-der-waals ICL3 R 288 - S6 L 87 N.S6.05
Hydrophobic ICL3 E 287 - S6 F 89 N.S6.07
Van-der-waals ICL3 E 287 - S6 F 89 N.S6.07
Hydrophobic H8 E 362 8x49 s5s6 D 75 N.s5s6.04
Hydrophobic ICL2 K 148 34x55 S16 Y 259 C.S16.03
Hydrophobic ICL3 R 288 - S6 Y 88 N.S6.06
Hydrophobic TM3 I 140 3x54 s5s6 I 76 N.s5s6.05
Hydrophobic TM6 K 298 6x32 s5s6 G 80 N.s5s6.09
Van-der-waals TM5 R 227 5x68 S6 R 85 N.S6.03
Ionic ICL3 E 287 - S6 R 91 N.S6.09
Polar ICL3 E 287 - S6 R 91 N.S6.09
Hydrophobic ICL3 E 287 - S6 R 91 N.S6.09
Van-der-waals ICL3 E 287 - S6 R 91 N.S6.09
Hydrophobic ICL2 L 144 34x51 S9 C 147 N.S9.01
Ionic H8 E 361 8x48 s9s10 K 170 N.s9s10.12
Polar H8 E 361 8x48 s9s10 K 170 N.s9s10.12
Hydrophobic H8 E 361 8x48 s9s10 K 170 N.s9s10.12
Van-der-waals H8 E 361 8x48 s9s10 K 170 N.s9s10.12
Hydrophobic TM7 Y 356 7x53 s5s6 V 78 N.s5s6.07
Hydrophobic H8 N 360 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic TM5 I 228 5x69 S6 F 83 N.S6.01
Hydrophobic ICL3 L 234 - s17s18 D 321 C.s17s18.37
Van-der-waals ICL3 L 234 - s17s18 D 321 C.s17s18.37
Hydrophobic TM3 I 140 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 I 140 3x54 S6 F 83 N.S6.01
Ionic TM6 R 297 6x31 s9s10 E 164 N.s9s10.06
Hydrophobic TM5 P 231 5x72 S6 R 85 N.S6.03
Ionic TM6 R 295 6x29 S6 D 86 N.S6.04
Polar TM6 R 295 6x29 S6 D 86 N.S6.04
Hydrophobic TM6 R 295 6x29 S6 D 86 N.S6.04
Van-der-waals TM6 R 295 6x29 S6 D 86 N.S6.04
Hydrophobic TM6 I 302 6x36 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 I 302 6x36 s5s6 G 80 N.s5s6.09
Hydrophobic TM5 P 232 5x73 S6 R 85 N.S6.03
Van-der-waals TM5 P 232 5x73 S6 R 85 N.S6.03
Hydrophobic TM5 A 224 5x65 S6 F 83 N.S6.01
Hydrophobic TM3 I 140 3x54 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 A 299 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 A 299 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic ICL3 S 284 - S6 F 89 N.S6.07
Van-der-waals ICL3 S 284 - S6 F 89 N.S6.07
Hydrophobic TM3 A 139 3x53 s5s6 I 76 N.s5s6.05
Van-der-waals TM3 A 139 3x53 s5s6 I 76 N.s5s6.05
Ionic TM6 K 298 6x32 s9s10 D 166 N.s9s10.08
Polar TM6 K 298 6x32 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 K 298 6x32 s9s10 D 166 N.s9s10.08
Hydrophobic TM6 I 302 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 I 302 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 R 136 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 136 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM5 I 220 5x61 s5s6 I 79 N.s5s6.08
Van-der-waals TM5 I 220 5x61 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 A 143 34x50 s5s6 G 72 N.s5s6.01
Van-der-waals ICL2 A 143 34x50 s5s6 G 72 N.s5s6.01
Hydrophobic ICL2 L 144 34x51 S8 L 136 N.S8.03
Hydrophobic TM5 Y 217 5x58 s5s6 I 79 N.s5s6.08
Polar H8 N 360 8x47 s5s6 D 75 N.s5s6.04
Polar ICL2 R 150 34x57 s5s6 Q 73 N.s5s6.02
Van-der-waals ICL2 R 150 34x57 s5s6 Q 73 N.s5s6.02
Hydrophobic ICL2 L 144 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 L 144 34x51 S16 D 257 C.S16.01
Hydrophobic ICL3 R 288 - S6 F 89 N.S6.07
Hydrophobic TM5 I 228 5x69 s5s6 T 82 N.s5s6.11
Hydrophobic TM6 L 303 6x37 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 L 303 6x37 s5s6 I 79 N.s5s6.08
Ionic ICL1 R 67 12x48 s20c E 394 C.s20c.13
Polar ICL1 R 67 12x48 s20c E 394 C.s20c.13
Hydrophobic TM6 A 299 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic TM5 I 228 5x69 s5s6 L 81 N.s5s6.10
Polar ICL2 L 144 34x51 S5 Y 71 N.S5.12
Hydrophobic ICL2 L 144 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 L 144 34x51 S5 Y 71 N.S5.12
Polar TM6 R 295 6x29 S6 R 84 N.S6.02
Hydrophobic ICL3 E 287 - s9s10 A 163 N.s9s10.05
Van-der-waals ICL3 E 287 - s9s10 A 163 N.s9s10.05
Ionic TM6 R 295 6x29 s9s10 E 165 N.s9s10.07
Polar TM6 R 295 6x29 s9s10 E 165 N.s9s10.07
Hydrophobic TM6 R 295 6x29 s9s10 E 165 N.s9s10.07
Van-der-waals TM6 R 295 6x29 s9s10 E 165 N.s9s10.07
Hydrophobic TM5 A 224 5x65 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 A 224 5x65 s5s6 L 81 N.s5s6.10
Hydrophobic TM6 I 302 6x36 s5s6 V 78 N.s5s6.07
Van-der-waals TM6 I 302 6x36 s5s6 V 78 N.s5s6.07
Hydrophobic ICL3 L 234 - s17s18 T 323 C.s17s18.39
Van-der-waals ICL3 L 234 - s17s18 T 323 C.s17s18.39
Hydrophobic ICL2 L 144 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 L 144 34x51 S16 Y 259 C.S16.03
Hydrophobic TM6 I 291 6x25 S6 F 89 N.S6.07
Ionic TM6 R 290 6x24 s9s10 D 162 N.s9s10.04
Polar TM6 R 290 6x24 s9s10 D 162 N.s9s10.04
Hydrophobic TM6 R 290 6x24 s9s10 D 162 N.s9s10.04
Van-der-waals TM6 R 290 6x24 s9s10 D 162 N.s9s10.04
Hydrophobic ICL3 L 234 - s17s18 V 324 C.s17s18.40
Van-der-waals ICL3 L 234 - s17s18 V 324 C.s17s18.40