Beta-arrestin-2 - 5-HT1E receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
5-HT1E 83.6
Beta-arrestin-2 79.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 16.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM2 Q 55 2x37 s8s9 T 137 N.s8s9.07
Hydrophobic TM2 Q 55 2x37 s8s9 T 137 N.s8s9.07
Van-der-waals TM2 Q 55 2x37 s8s9 T 137 N.s8s9.07
Polar TM2 Q 55 2x37 s8s9 E 135 N.s8s9.05
Van-der-waals TM2 Q 55 2x37 s8s9 E 135 N.s8s9.05
Hydrophobic TM7 Y 344 7x53 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 Y 344 7x53 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 L 212 5x68 S6 R 77 N.S6.02
Hydrophobic TM5 S 219 5x75 s17s18 V 315 C.s17s18.40
Van-der-waals TM5 S 219 5x75 s17s18 V 315 C.s17s18.40
Polar ICL2 E 129 34x52 S16 Y 250 C.S16.03
Van-der-waals ICL2 E 129 34x52 S16 Y 250 C.S16.03
Polar TM5 Y 213 5x69 s5s6 S 75 N.s5s6.11
Polar ICL2 R 132 34x55 s17s18 R 286 C.s17s18.11
Hydrophobic TM5 Y 213 5x69 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 Y 213 5x69 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 I 124 3x54 S5 Y 64 N.S5.12
Hydrophobic ICL2 R 134 34x57 s5s6 R 66 N.s5s6.02
Polar ICL2 I 128 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 I 128 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 I 128 34x51 S5 Y 64 N.S5.12
Polar TM5 R 216 5x72 S6 R 77 N.S6.02
Hydrophobic TM5 R 216 5x72 S6 R 77 N.S6.02
Van-der-waals TM5 R 216 5x72 S6 R 77 N.S6.02
Ionic ICL1 K 52 12x49 s5s6 E 67 N.s5s6.03
Polar ICL1 K 52 12x49 s5s6 E 67 N.s5s6.03
Van-der-waals ICL1 K 52 12x49 s5s6 E 67 N.s5s6.03
Hydrophobic TM5 R 216 5x72 S6 K 78 N.S6.03
Van-der-waals TM5 R 216 5x72 S6 K 78 N.S6.03
Hydrophobic ICL2 I 128 34x51 S16 A 248 C.S16.01
Ionic TM5 R 216 5x72 S6 D 79 N.S6.04
Polar TM5 R 216 5x72 S6 D 79 N.S6.04
Hydrophobic TM5 R 216 5x72 S6 D 79 N.S6.04
Van-der-waals TM5 R 216 5x72 S6 D 79 N.S6.04
Hydrophobic TM5 I 205 5x61 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 I 124 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 I 124 3x54 s5s6 L 69 N.s5s6.05
Ionic TM5 K 215 5x71 s17s18 E 314 C.s17s18.39
Polar TM5 K 215 5x71 s17s18 E 314 C.s17s18.39
Van-der-waals TM5 K 215 5x71 s17s18 E 314 C.s17s18.39
Hydrophobic H8 N 348 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 N 348 8x47 s5s6 V 71 N.s5s6.07
Polar ICL2 A 131 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic TM6 I 296 6x40 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 I 296 6x40 s5s6 L 72 N.s5s6.08
Ionic TM6 R 285 6x29 S6 D 79 N.S6.04
Polar TM6 R 285 6x29 S6 D 79 N.S6.04
Polar TM2 Q 55 2x37 s5s6 R 66 N.s5s6.02
Van-der-waals TM2 Q 55 2x37 s5s6 R 66 N.s5s6.02
Hydrophobic TM5 A 209 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 A 209 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 L 212 5x68 S6 K 78 N.S6.03
Hydrophobic TM6 A 289 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 289 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic ICL3 L 222 - s17s18 V 315 C.s17s18.40
Hydrophobic ICL2 I 128 34x51 S8 L 130 N.S8.03
Van-der-waals ICL2 I 128 34x51 S8 L 130 N.S8.03
Hydrophobic TM5 Y 202 5x58 s5s6 L 72 N.s5s6.08
Polar ICL2 A 127 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 A 127 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 A 127 34x50 S5 Y 64 N.S5.12
Hydrophobic TM5 I 205 5x61 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 I 205 5x61 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 I 124 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 R 120 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 R 132 34x55 S16 Y 250 C.S16.03
Van-der-waals ICL2 R 132 34x55 S16 Y 250 C.S16.03
Polar TM5 R 220 5x76 S6 I 82 N.S6.07
Hydrophobic TM5 R 220 5x76 S6 I 82 N.S6.07
Van-der-waals TM5 R 220 5x76 S6 I 82 N.S6.07
Hydrophobic ICL2 I 128 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic ICL3 L 222 - s7s8 N 123 N.s7s8.05
Van-der-waals ICL3 L 222 - s7s8 N 123 N.s7s8.05
Aromatic TM5 R 220 5x76 S6 F 81 N.S6.06
Hydrophobic TM5 R 220 5x76 S6 F 81 N.S6.06
Hydrophobic TM5 A 209 5x65 S6 F 76 N.S6.01
Hydrophobic ICL2 E 129 34x52 S16 A 248 C.S16.01
Van-der-waals ICL2 E 129 34x52 S16 A 248 C.S16.01
Polar TM5 K 215 5x71 S6 K 78 N.S6.03
Hydrophobic TM5 K 215 5x71 S6 K 78 N.S6.03
Van-der-waals TM5 K 215 5x71 S6 K 78 N.S6.03
Hydrophobic TM3 I 124 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 I 124 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 I 124 3x54 S6 F 76 N.S6.01
Hydrophobic TM3 A 123 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 123 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic TM6 L 293 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 293 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 I 292 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM2 A 57 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 A 57 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM5 L 212 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 L 212 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 L 212 5x68 S6 F 76 N.S6.01
Van-der-waals TM5 L 212 5x68 S6 F 76 N.S6.01
Polar ICL2 I 128 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 I 128 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 I 128 34x51 S16 Y 250 C.S16.03
Polar TM6 R 285 6x29 s5s6 S 75 N.s5s6.11
Ionic ICL2 R 134 34x57 s5s6 D 68 N.s5s6.04
Polar ICL2 R 134 34x57 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 R 134 34x57 s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 R 134 34x57 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 R 120 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 120 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 I 128 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 I 128 34x51 S15 I 242 C.S15.14
Hydrophobic TM6 I 292 6x36 s5s6 G 73 N.s5s6.09