Beta-arrestin-2 - 5-HT1F receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
5-HT1F 81.3
Beta-arrestin-2 79.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 17.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 A 128 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 A 128 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 A 128 34x50 S5 Y 64 N.S5.12
Polar TM5 S 218 5x75 S6 K 78 N.S6.03
Hydrophobic TM5 S 218 5x75 S6 K 78 N.S6.03
Van-der-waals TM5 S 218 5x75 S6 K 78 N.S6.03
Ionic ICL3 R 279 - s9s10 E 156 N.s9s10.07
Polar ICL3 R 279 - s9s10 E 156 N.s9s10.07
Hydrophobic ICL3 R 279 - s9s10 E 156 N.s9s10.07
Van-der-waals ICL3 R 279 - s9s10 E 156 N.s9s10.07
Hydrophobic TM3 I 125 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 I 125 3x54 s5s6 L 69 N.s5s6.05
Polar ICL2 R 135 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 R 135 34x57 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 R 135 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic ICL3 R 279 - s9s10 L 155 N.s9s10.03
Van-der-waals ICL3 R 279 - s9s10 L 155 N.s9s10.03
Polar TM5 Y 212 5x69 s5s6 G 73 N.s5s6.09
Polar TM6 R 287 6x29 S6 R 77 N.S6.02
Ionic TM2 H 56 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 H 56 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 V 129 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 V 129 34x51 S16 A 248 C.S16.01
Hydrophobic TM5 R 215 5x72 S6 K 78 N.S6.03
Van-der-waals TM5 R 215 5x72 S6 K 78 N.S6.03
Hydrophobic TM5 A 208 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 A 208 5x65 s5s6 L 74 N.s5s6.10
Polar TM5 R 215 5x72 s5s6 S 75 N.s5s6.11
Van-der-waals TM5 R 215 5x72 s5s6 S 75 N.s5s6.11
Ionic TM5 R 219 5x76 S6 D 79 N.S6.04
Polar TM5 R 219 5x76 S6 D 79 N.S6.04
Hydrophobic TM5 R 219 5x76 S6 D 79 N.S6.04
Van-der-waals TM5 R 219 5x76 S6 D 79 N.S6.04
Ionic ICL1 R 52 12x48 s20c D 402 C.s20c.12
Polar ICL1 R 52 12x48 s20c D 402 C.s20c.12
Hydrophobic TM4 P 137 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 P 137 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM5 L 211 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 L 211 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic ICL1 K 53 12x49 s8s9 T 137 N.s8s9.07
Hydrophobic TM3 I 125 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 I 125 3x54 s5s6 L 74 N.s5s6.10
Polar ICL3 R 280 - S6 I 82 N.S6.07
Hydrophobic ICL3 R 280 - S6 I 82 N.S6.07
Van-der-waals ICL3 R 280 - S6 I 82 N.S6.07
Van-der-waals H8 D 353 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic TM3 I 125 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 I 125 3x54 S6 F 76 N.S6.01
Hydrophobic TM5 I 204 5x61 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 R 121 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 121 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 T 294 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 V 129 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 I 125 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 R 121 3x50 s5s6 L 72 N.s5s6.08
Polar ICL2 V 129 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 V 129 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 V 129 34x51 S16 Y 250 C.S16.03
Hydrophobic H8 N 351 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 Y 212 5x69 s5s6 L 74 N.s5s6.10
Hydrophobic TM2 A 58 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 A 58 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic ICL1 R 52 12x48 s20c K 400 C.s20c.10
Van-der-waals ICL1 R 52 12x48 s20c K 400 C.s20c.10
Hydrophobic TM5 Y 201 5x58 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 I 204 5x61 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 A 124 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 124 3x53 s5s6 L 69 N.s5s6.05
Ionic ICL1 K 53 12x49 s5s6 E 67 N.s5s6.03
Polar ICL1 K 53 12x49 s5s6 E 67 N.s5s6.03
Van-der-waals ICL1 K 53 12x49 s5s6 E 67 N.s5s6.03
Hydrophobic TM5 L 211 5x68 S6 F 76 N.S6.01
Van-der-waals TM5 L 211 5x68 S6 F 76 N.S6.01
Polar TM5 K 214 5x71 S6 K 78 N.S6.03
Hydrophobic TM5 K 214 5x71 S6 K 78 N.S6.03
Hydrophobic TM5 R 215 5x72 S6 F 76 N.S6.01
Van-der-waals TM5 R 215 5x72 S6 F 76 N.S6.01
Van-der-waals TM6 A 291 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 I 298 6x40 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 I 298 6x40 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 E 130 34x52 S16 A 248 C.S16.01
Hydrophobic TM7 Y 347 7x53 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 Y 347 7x53 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 V 129 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 V 129 34x51 S15 I 242 C.S15.14
Polar ICL2 V 129 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 V 129 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 V 129 34x51 S5 Y 64 N.S5.12
Polar ICL2 A 132 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 A 132 34x54 s5s6 R 66 N.s5s6.02
Polar ICL3 K 222 - s7s8 N 123 N.s7s8.05
Hydrophobic ICL3 K 222 - s7s8 N 123 N.s7s8.05
Van-der-waals ICL3 K 222 - s7s8 N 123 N.s7s8.05
Ionic TM5 K 214 5x71 s17s18 E 314 C.s17s18.39
Polar TM5 K 214 5x71 s17s18 E 314 C.s17s18.39
Van-der-waals TM5 K 214 5x71 s17s18 E 314 C.s17s18.39
Hydrophobic TM6 A 291 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 291 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 T 294 6x36 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 T 294 6x36 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 L 295 6x37 s5s6 L 72 N.s5s6.08
Polar TM5 R 215 5x72 S6 R 77 N.S6.02
Hydrophobic TM5 R 215 5x72 S6 R 77 N.S6.02
Van-der-waals TM5 R 215 5x72 S6 R 77 N.S6.02
Hydrophobic TM5 R 219 5x76 S6 I 82 N.S6.07
Van-der-waals TM5 R 219 5x76 S6 I 82 N.S6.07
Ionic ICL2 R 135 34x57 s5s6 D 68 N.s5s6.04
Polar ICL2 R 135 34x57 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 R 135 34x57 s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 R 135 34x57 s5s6 D 68 N.s5s6.04