Arrestin-C - 5-HT1F receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
5-HT1F 79.6
Arrestin-C 81.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic H8 N 351 8x47 s5s6 V 66 N.s5s6.07
Van-der-waals H8 N 351 8x47 s5s6 V 66 N.s5s6.07
Hydrophobic TM6 I 298 6x40 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 I 125 3x54 s5s6 I 67 N.s5s6.08
Polar ICL3 H 274 - s6h1 E 86 N.s6h1.03
Hydrophobic ICL3 H 274 - s6h1 E 86 N.s6h1.03
Van-der-waals ICL3 H 274 - s6h1 E 86 N.s6h1.03
Hydrophobic TM6 A 291 6x33 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 A 291 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic TM3 R 121 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 121 3x50 s5s6 I 67 N.s5s6.08
Ionic ICL2 R 135 34x57 s5s6 D 63 N.s5s6.04
Polar ICL2 R 135 34x57 s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 R 135 34x57 s5s6 D 63 N.s5s6.04
Van-der-waals ICL2 R 135 34x57 s5s6 D 63 N.s5s6.04
Ionic ICL3 R 280 - s9s10 E 152 N.s9s10.07
Polar ICL3 R 280 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL3 R 280 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 R 280 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL2 R 135 34x57 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 R 135 34x57 s5s6 R 61 N.s5s6.02
Hydrophobic TM3 R 121 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 121 3x50 s5s6 V 66 N.s5s6.07
Ionic ICL3 R 279 - s9s10 E 153 N.s9s10.08
Polar ICL3 R 279 - s9s10 E 153 N.s9s10.08
Hydrophobic ICL3 R 279 - s9s10 E 153 N.s9s10.08
Van-der-waals ICL3 R 279 - s9s10 E 153 N.s9s10.08
Hydrophobic ICL2 V 129 34x51 s15s16 S 242 C.s15s16.04
Polar ICL2 V 129 34x51 s15s16 L 243 C.s15s16.05
Hydrophobic ICL2 V 129 34x51 s15s16 L 243 C.s15s16.05
Van-der-waals ICL2 V 129 34x51 s15s16 L 243 C.s15s16.05
Ionic ICL3 E 275 - S5 K 48 N.S5.01
Polar ICL3 E 275 - S5 K 48 N.S5.01
Van-der-waals ICL3 E 275 - S5 K 48 N.S5.01
Polar ICL3 R 280 - s9s10 P 151 N.s9s10.03
Hydrophobic ICL3 R 280 - s9s10 P 151 N.s9s10.03
Van-der-waals ICL3 R 280 - s9s10 P 151 N.s9s10.03
Polar TM6 I 283 6x25 s9s10 T 154 N.s9s10.09
Hydrophobic TM6 I 283 6x25 s9s10 T 154 N.s9s10.09
Van-der-waals TM6 I 283 6x25 s9s10 T 154 N.s9s10.09
Hydrophobic TM6 T 294 6x36 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 T 294 6x36 s5s6 I 67 N.s5s6.08
Ionic TM6 K 282 6x24 s9s10 E 153 N.s9s10.08
Polar TM6 K 282 6x24 s9s10 E 153 N.s9s10.08
Hydrophobic TM6 K 282 6x24 s9s10 E 153 N.s9s10.08
Van-der-waals TM6 K 282 6x24 s9s10 E 153 N.s9s10.08
Polar TM2 H 56 2x37 s8s9 K 135 N.s8s9.09
Hydrophobic TM2 H 56 2x37 s8s9 K 135 N.s8s9.09
Van-der-waals TM2 H 56 2x37 s8s9 K 135 N.s8s9.09
Polar TM2 H 56 2x37 s8s9 A 133 N.s8s9.07
Hydrophobic TM2 H 56 2x37 s8s9 A 133 N.s8s9.07
Van-der-waals TM2 H 56 2x37 s8s9 A 133 N.s8s9.07
Hydrophobic TM3 I 125 3x54 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 I 125 3x54 s5s6 L 69 N.s5s6.10
Hydrophobic TM3 I 125 3x54 S6 F 71 N.S6.01
Van-der-waals TM3 I 125 3x54 S6 F 71 N.S6.01
Polar ICL2 R 133 34x55 s15s16 L 243 C.s15s16.05
Hydrophobic ICL2 R 133 34x55 s15s16 L 243 C.s15s16.05
Van-der-waals ICL2 R 133 34x55 s15s16 L 243 C.s15s16.05
Hydrophobic ICL2 A 132 34x54 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 A 132 34x54 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 L 211 5x68 s15s16 Y 241 C.s15s16.03
Polar ICL2 V 129 34x51 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 V 129 34x51 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 V 129 34x51 s15s16 Y 241 C.s15s16.03
Ionic ICL3 K 276 - s6h1 E 86 N.s6h1.03
Hydrophobic ICL3 K 276 - s6h1 E 86 N.s6h1.03
Van-der-waals ICL3 K 276 - s6h1 E 86 N.s6h1.03
Hydrophobic ICL2 V 129 34x51 s15s16 L 240 C.s15s16.02
Polar ICL3 Q 281 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 Q 281 - s9s10 E 152 N.s9s10.07
Polar ICL3 R 279 - s9s10 N 150 N.s9s10.02
Hydrophobic ICL3 R 279 - s9s10 N 150 N.s9s10.02
Ionic TM5 R 215 5x72 S6 D 74 N.S6.04
Polar TM5 R 215 5x72 S6 D 74 N.S6.04
Hydrophobic TM5 R 215 5x72 S6 D 74 N.S6.04
Van-der-waals TM5 R 215 5x72 S6 D 74 N.S6.04
Polar TM6 K 282 6x24 s9s10 T 154 N.s9s10.09
Hydrophobic TM6 K 282 6x24 s9s10 T 154 N.s9s10.09
Van-der-waals TM6 K 282 6x24 s9s10 T 154 N.s9s10.09
Hydrophobic TM3 I 125 3x54 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 I 125 3x54 s5s6 L 64 N.s5s6.05
Hydrophobic ICL3 K 276 - S5 F 50 N.S5.03
Van-der-waals ICL3 K 276 - S5 F 50 N.S5.03
Polar TM5 R 215 5x72 S6 R 72 N.S6.02
Hydrophobic TM5 R 215 5x72 S6 R 72 N.S6.02
Van-der-waals TM5 R 215 5x72 S6 R 72 N.S6.02
Hydrophobic TM5 R 219 5x76 S6 V 77 N.S6.07
Van-der-waals TM5 R 219 5x76 S6 V 77 N.S6.07
Polar ICL3 S 277 - s9s10 N 150 N.s9s10.02
Van-der-waals ICL3 S 277 - s9s10 N 150 N.s9s10.02
Hydrophobic TM5 A 208 5x65 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 A 208 5x65 s5s6 L 69 N.s5s6.10
Polar ICL3 K 276 - S6 L 80 N.S6.10
Hydrophobic ICL3 K 276 - S6 L 80 N.S6.10
Van-der-waals ICL3 K 276 - S6 L 80 N.S6.10
Ionic TM5 R 219 5x76 S6 D 74 N.S6.04
Polar TM5 Q 216 5x73 s9s10 E 152 N.s9s10.07
Hydrophobic TM5 Q 216 5x73 s9s10 E 152 N.s9s10.07
Van-der-waals TM5 Q 216 5x73 s9s10 E 152 N.s9s10.07
Hydrophobic ICL3 K 276 - s9s10 P 151 N.s9s10.03
Van-der-waals ICL3 K 276 - s9s10 P 151 N.s9s10.03
Ionic TM5 R 219 5x76 s9s10 E 152 N.s9s10.07
Polar TM5 R 219 5x76 s9s10 E 152 N.s9s10.07
Hydrophobic TM5 R 219 5x76 s9s10 E 152 N.s9s10.07
Van-der-waals TM5 R 219 5x76 s9s10 E 152 N.s9s10.07
Hydrophobic TM5 I 204 5x61 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 A 128 34x50 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 A 128 34x50 s15s16 Y 241 C.s15s16.03
Polar ICL1 R 52 12x48 s8s9 P 130 N.s8s9.04
Hydrophobic ICL1 R 52 12x48 s8s9 P 130 N.s8s9.04
Polar ICL3 R 279 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL3 R 279 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 R 279 - s9s10 E 152 N.s9s10.07
Hydrophobic TM5 Y 201 5x58 s5s6 I 67 N.s5s6.08
Polar TM3 R 121 3x50 s5s6 D 63 N.s5s6.04
Hydrophobic ICL3 K 276 - S6 T 79 N.S6.09
Hydrophobic ICL3 R 280 - S5 M 52 N.S5.05
Van-der-waals ICL3 R 280 - S5 M 52 N.S5.05
Hydrophobic TM5 L 211 5x68 S6 F 71 N.S6.01
Hydrophobic ICL2 A 132 34x54 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 A 132 34x54 s15s16 S 242 C.s15s16.04
Polar ICL3 R 279 - s9s10 T 154 N.s9s10.09
Van-der-waals ICL3 R 279 - s9s10 T 154 N.s9s10.09
Hydrophobic TM6 K 290 6x32 s5s6 G 68 N.s5s6.09
Polar H8 N 351 8x47 s5s6 D 62 N.s5s6.03
Hydrophobic H8 N 351 8x47 s5s6 D 62 N.s5s6.03
Van-der-waals H8 N 351 8x47 s5s6 D 62 N.s5s6.03
Hydrophobic ICL3 W 278 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 W 278 - s9s10 E 152 N.s9s10.07
Polar ICL3 E 275 - s9s10 N 150 N.s9s10.02
Hydrophobic ICL3 E 275 - s9s10 N 150 N.s9s10.02
Van-der-waals ICL3 E 275 - s9s10 N 150 N.s9s10.02
Hydrophobic ICL3 K 276 - s9s10 N 150 N.s9s10.02
Van-der-waals ICL3 K 276 - s9s10 N 150 N.s9s10.02
Polar TM6 R 287 6x29 s5s6 T 70 N.s5s6.11
Hydrophobic TM7 F 350 7x56 s5s6 V 66 N.s5s6.07
Polar ICL3 W 278 - s9s10 N 150 N.s9s10.02
Hydrophobic ICL3 W 278 - s9s10 N 150 N.s9s10.02
Van-der-waals ICL3 W 278 - s9s10 N 150 N.s9s10.02
Polar TM6 T 286 6x28 s9s10 T 154 N.s9s10.09
Hydrophobic TM6 T 286 6x28 s9s10 T 154 N.s9s10.09
Van-der-waals TM6 T 286 6x28 s9s10 T 154 N.s9s10.09
Hydrophobic TM2 A 58 2x39 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 A 58 2x39 s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 A 132 34x54 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 A 132 34x54 s5s6 R 61 N.s5s6.02
Hydrophobic ICL3 S 277 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 S 277 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL3 K 276 - S6 Q 81 N.S6.11
Van-der-waals ICL3 K 276 - S6 Q 81 N.S6.11
Polar ICL3 K 276 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL3 K 276 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 K 276 - s9s10 E 152 N.s9s10.07
Polar ICL3 R 280 - S6 T 79 N.S6.09
Hydrophobic ICL3 R 280 - S6 T 79 N.S6.09
Van-der-waals ICL3 R 280 - S6 T 79 N.S6.09
Polar ICL3 E 223 - S6 T 79 N.S6.09
Hydrophobic ICL3 E 223 - S6 T 79 N.S6.09
Van-der-waals ICL3 E 223 - S6 T 79 N.S6.09
Hydrophobic TM7 Y 347 7x53 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 Y 347 7x53 s5s6 V 66 N.s5s6.07
Hydrophobic TM6 I 283 6x25 s9s10 E 153 N.s9s10.08
Van-der-waals TM6 I 283 6x25 s9s10 E 153 N.s9s10.08
Hydrophobic ICL3 R 280 - s9s10 E 153 N.s9s10.08
Van-der-waals ICL3 R 280 - s9s10 E 153 N.s9s10.08
Hydrophobic TM6 T 294 6x36 s5s6 V 66 N.s5s6.07
Van-der-waals TM6 T 294 6x36 s5s6 V 66 N.s5s6.07
Ionic ICL1 R 52 12x48 s8s9 E 131 N.s8s9.05
Polar ICL1 R 52 12x48 s8s9 E 131 N.s8s9.05
Hydrophobic ICL1 R 52 12x48 s8s9 E 131 N.s8s9.05
Van-der-waals ICL1 R 52 12x48 s8s9 E 131 N.s8s9.05
Hydrophobic TM6 I 283 6x25 S9 K 144 N.S9.08
Van-der-waals TM6 I 283 6x25 S9 K 144 N.S9.08
Ionic ICL3 R 279 - s9s10 E 149 N.s9s10.01
Polar ICL3 R 279 - s9s10 E 149 N.s9s10.01
Hydrophobic ICL3 R 279 - s9s10 E 149 N.s9s10.01
Van-der-waals ICL3 R 279 - s9s10 E 149 N.s9s10.01
Polar ICL3 H 274 - s6h1 S 88 N.s6h1.05
Hydrophobic TM5 R 219 5x76 S5 M 52 N.S5.05
Van-der-waals TM5 R 219 5x76 S5 M 52 N.S5.05
Hydrophobic ICL2 A 128 34x50 S6 F 71 N.S6.01