ArrestinDb

Arrestin-C - 5-HT_1F receptor complex model

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Tertiary structure confidence

Chain	pLDDT score avg
5-HT_1F	79.6
Arrestin-C	81.1

Very high (>90)

Confident (90-70)

Low (70-50)

Very low (<50)

Disordered

PTM Score: 0.6

iPTM Score: 0.4

PAE mean: 21.7

GPCR - Arrestin interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Hydrophobic	H8	N	351	8x47	s5s6	V	66	N.s5s6.07
Hydrophobic	TM6	I	298	6x40	s5s6	I	67	N.s5s6.08
Hydrophobic	TM3	I	125	3x54	s5s6	I	67	N.s5s6.08
Hydrophobic	ICL3	H	274	-	s6h1	E	86	N.s6h1.03
Hydrophobic	TM6	A	291	6x33	s5s6	L	69	N.s5s6.10
Hydrophobic	TM3	R	121	3x50	s5s6	I	67	N.s5s6.08
Hydrophobic	ICL2	R	135	34x57	s5s6	D	63	N.s5s6.04
Hydrophobic	ICL3	R	280	-	s9s10	E	152	N.s9s10.07
Hydrophobic	ICL2	R	135	34x57	s5s6	R	61	N.s5s6.02
Hydrophobic	TM3	R	121	3x50	s5s6	V	66	N.s5s6.07
Hydrophobic	ICL3	R	279	-	s9s10	E	153	N.s9s10.08
Hydrophobic	ICL2	V	129	34x51	s15s16	S	242	C.s15s16.04
Hydrophobic	ICL2	V	129	34x51	s15s16	L	243	C.s15s16.05
Hydrophobic	ICL3	R	280	-	s9s10	P	151	N.s9s10.03
Hydrophobic	TM6	I	283	6x25	s9s10	T	154	N.s9s10.09
Hydrophobic	TM6	T	294	6x36	s5s6	I	67	N.s5s6.08
Hydrophobic	TM6	K	282	6x24	s9s10	E	153	N.s9s10.08
Hydrophobic	TM2	H	56	2x37	s8s9	K	135	N.s8s9.09
Hydrophobic	TM2	H	56	2x37	s8s9	A	133	N.s8s9.07
Hydrophobic	TM3	I	125	3x54	s5s6	L	69	N.s5s6.10
Hydrophobic	TM3	I	125	3x54	S6	F	71	N.S6.01
Hydrophobic	ICL2	R	133	34x55	s15s16	L	243	C.s15s16.05
Hydrophobic	ICL2	A	132	34x54	s15s16	Y	241	C.s15s16.03
Hydrophobic	ICL2	V	129	34x51	s15s16	Y	241	C.s15s16.03
Hydrophobic	ICL3	K	276	-	s6h1	E	86	N.s6h1.03
Hydrophobic	ICL2	V	129	34x51	s15s16	L	240	C.s15s16.02
Hydrophobic	ICL3	R	279	-	s9s10	N	150	N.s9s10.02
Hydrophobic	TM5	R	215	5x72	S6	D	74	N.S6.04
Hydrophobic	TM6	K	282	6x24	s9s10	T	154	N.s9s10.09
Hydrophobic	TM3	I	125	3x54	s5s6	L	64	N.s5s6.05
Hydrophobic	ICL3	K	276	-	S5	F	50	N.S5.03
Hydrophobic	TM5	R	215	5x72	S6	R	72	N.S6.02
Hydrophobic	TM5	R	219	5x76	S6	V	77	N.S6.07
Hydrophobic	TM5	A	208	5x65	s5s6	L	69	N.s5s6.10
Hydrophobic	ICL3	K	276	-	S6	L	80	N.S6.10
Hydrophobic	TM5	Q	216	5x73	s9s10	E	152	N.s9s10.07
Hydrophobic	ICL3	K	276	-	s9s10	P	151	N.s9s10.03
Hydrophobic	TM5	R	219	5x76	s9s10	E	152	N.s9s10.07
Hydrophobic	TM5	I	204	5x61	s5s6	L	69	N.s5s6.10
Hydrophobic	ICL2	A	128	34x50	s15s16	Y	241	C.s15s16.03
Hydrophobic	ICL1	R	52	12x48	s8s9	P	130	N.s8s9.04
Hydrophobic	ICL3	R	279	-	s9s10	E	152	N.s9s10.07
Hydrophobic	TM5	Y	201	5x58	s5s6	I	67	N.s5s6.08
Hydrophobic	ICL3	K	276	-	S6	T	79	N.S6.09
Hydrophobic	ICL3	R	280	-	S5	M	52	N.S5.05
Hydrophobic	TM5	L	211	5x68	S6	F	71	N.S6.01
Hydrophobic	ICL2	A	132	34x54	s15s16	S	242	C.s15s16.04
Hydrophobic	TM6	K	290	6x32	s5s6	G	68	N.s5s6.09
Hydrophobic	H8	N	351	8x47	s5s6	D	62	N.s5s6.03
Hydrophobic	ICL3	W	278	-	s9s10	E	152	N.s9s10.07
Hydrophobic	ICL3	E	275	-	s9s10	N	150	N.s9s10.02
Hydrophobic	ICL3	K	276	-	s9s10	N	150	N.s9s10.02
Hydrophobic	TM7	F	350	7x56	s5s6	V	66	N.s5s6.07
Hydrophobic	ICL3	W	278	-	s9s10	N	150	N.s9s10.02
Hydrophobic	TM6	T	286	6x28	s9s10	T	154	N.s9s10.09
Hydrophobic	TM2	A	58	2x39	s5s6	D	63	N.s5s6.04
Hydrophobic	ICL2	A	132	34x54	s5s6	R	61	N.s5s6.02
Hydrophobic	ICL3	S	277	-	s9s10	E	152	N.s9s10.07
Hydrophobic	ICL3	K	276	-	S6	Q	81	N.S6.11
Hydrophobic	ICL3	K	276	-	s9s10	E	152	N.s9s10.07
Hydrophobic	ICL3	R	280	-	S6	T	79	N.S6.09
Hydrophobic	ICL3	E	223	-	S6	T	79	N.S6.09
Hydrophobic	TM7	Y	347	7x53	s5s6	V	66	N.s5s6.07
Hydrophobic	TM6	I	283	6x25	s9s10	E	153	N.s9s10.08
Hydrophobic	ICL3	R	280	-	s9s10	E	153	N.s9s10.08
Hydrophobic	TM6	T	294	6x36	s5s6	V	66	N.s5s6.07
Hydrophobic	ICL1	R	52	12x48	s8s9	E	131	N.s8s9.05
Hydrophobic	TM6	I	283	6x25	S9	K	144	N.S9.08
Hydrophobic	ICL3	R	279	-	s9s10	E	149	N.s9s10.01
Hydrophobic	TM5	R	219	5x76	S5	M	52	N.S5.05
Hydrophobic	ICL2	A	128	34x50	S6	F	71	N.S6.01
Ionic	ICL2	R	135	34x57	s5s6	D	63	N.s5s6.04
Ionic	ICL3	R	280	-	s9s10	E	152	N.s9s10.07
Ionic	ICL3	R	279	-	s9s10	E	153	N.s9s10.08
Ionic	ICL3	E	275	-	S5	K	48	N.S5.01
Ionic	TM6	K	282	6x24	s9s10	E	153	N.s9s10.08
Ionic	ICL3	K	276	-	s6h1	E	86	N.s6h1.03
Ionic	TM5	R	215	5x72	S6	D	74	N.S6.04
Ionic	TM5	R	219	5x76	S6	D	74	N.S6.04
Ionic	TM5	R	219	5x76	s9s10	E	152	N.s9s10.07
Ionic	ICL1	R	52	12x48	s8s9	E	131	N.s8s9.05
Ionic	ICL3	R	279	-	s9s10	E	149	N.s9s10.01
Polar	ICL3	H	274	-	s6h1	E	86	N.s6h1.03
Polar	ICL2	R	135	34x57	s5s6	D	63	N.s5s6.04
Polar	ICL3	R	280	-	s9s10	E	152	N.s9s10.07
Polar	ICL3	R	279	-	s9s10	E	153	N.s9s10.08
Polar	ICL2	V	129	34x51	s15s16	L	243	C.s15s16.05
Polar	ICL3	E	275	-	S5	K	48	N.S5.01
Polar	ICL3	R	280	-	s9s10	P	151	N.s9s10.03
Polar	TM6	I	283	6x25	s9s10	T	154	N.s9s10.09
Polar	TM6	K	282	6x24	s9s10	E	153	N.s9s10.08
Polar	TM2	H	56	2x37	s8s9	K	135	N.s8s9.09
Polar	TM2	H	56	2x37	s8s9	A	133	N.s8s9.07
Polar	ICL2	R	133	34x55	s15s16	L	243	C.s15s16.05
Polar	ICL2	V	129	34x51	s15s16	Y	241	C.s15s16.03
Polar	ICL3	Q	281	-	s9s10	E	152	N.s9s10.07
Polar	ICL3	R	279	-	s9s10	N	150	N.s9s10.02
Polar	TM5	R	215	5x72	S6	D	74	N.S6.04
Polar	TM6	K	282	6x24	s9s10	T	154	N.s9s10.09
Polar	TM5	R	215	5x72	S6	R	72	N.S6.02
Polar	ICL3	S	277	-	s9s10	N	150	N.s9s10.02
Polar	ICL3	K	276	-	S6	L	80	N.S6.10
Polar	TM5	Q	216	5x73	s9s10	E	152	N.s9s10.07
Polar	TM5	R	219	5x76	s9s10	E	152	N.s9s10.07
Polar	ICL1	R	52	12x48	s8s9	P	130	N.s8s9.04
Polar	ICL3	R	279	-	s9s10	E	152	N.s9s10.07
Polar	TM3	R	121	3x50	s5s6	D	63	N.s5s6.04
Polar	ICL3	R	279	-	s9s10	T	154	N.s9s10.09
Polar	H8	N	351	8x47	s5s6	D	62	N.s5s6.03
Polar	ICL3	E	275	-	s9s10	N	150	N.s9s10.02
Polar	TM6	R	287	6x29	s5s6	T	70	N.s5s6.11
Polar	ICL3	W	278	-	s9s10	N	150	N.s9s10.02
Polar	TM6	T	286	6x28	s9s10	T	154	N.s9s10.09
Polar	ICL3	K	276	-	s9s10	E	152	N.s9s10.07
Polar	ICL3	R	280	-	S6	T	79	N.S6.09
Polar	ICL3	E	223	-	S6	T	79	N.S6.09
Polar	ICL1	R	52	12x48	s8s9	E	131	N.s8s9.05
Polar	ICL3	R	279	-	s9s10	E	149	N.s9s10.01
Polar	ICL3	H	274	-	s6h1	S	88	N.s6h1.05
Van-der-waals	H8	N	351	8x47	s5s6	V	66	N.s5s6.07
Van-der-waals	ICL3	H	274	-	s6h1	E	86	N.s6h1.03
Van-der-waals	TM6	A	291	6x33	s5s6	L	69	N.s5s6.10
Van-der-waals	TM3	R	121	3x50	s5s6	I	67	N.s5s6.08
Van-der-waals	ICL2	R	135	34x57	s5s6	D	63	N.s5s6.04
Van-der-waals	ICL3	R	280	-	s9s10	E	152	N.s9s10.07
Van-der-waals	ICL2	R	135	34x57	s5s6	R	61	N.s5s6.02
Van-der-waals	TM3	R	121	3x50	s5s6	V	66	N.s5s6.07
Van-der-waals	ICL3	R	279	-	s9s10	E	153	N.s9s10.08
Van-der-waals	ICL2	V	129	34x51	s15s16	L	243	C.s15s16.05
Van-der-waals	ICL3	E	275	-	S5	K	48	N.S5.01
Van-der-waals	ICL3	R	280	-	s9s10	P	151	N.s9s10.03
Van-der-waals	TM6	I	283	6x25	s9s10	T	154	N.s9s10.09
Van-der-waals	TM6	T	294	6x36	s5s6	I	67	N.s5s6.08
Van-der-waals	TM6	K	282	6x24	s9s10	E	153	N.s9s10.08
Van-der-waals	TM2	H	56	2x37	s8s9	K	135	N.s8s9.09
Van-der-waals	TM2	H	56	2x37	s8s9	A	133	N.s8s9.07
Van-der-waals	TM3	I	125	3x54	s5s6	L	69	N.s5s6.10
Van-der-waals	TM3	I	125	3x54	S6	F	71	N.S6.01
Van-der-waals	ICL2	R	133	34x55	s15s16	L	243	C.s15s16.05
Van-der-waals	ICL2	A	132	34x54	s15s16	Y	241	C.s15s16.03
Van-der-waals	TM5	L	211	5x68	s15s16	Y	241	C.s15s16.03
Van-der-waals	ICL2	V	129	34x51	s15s16	Y	241	C.s15s16.03
Van-der-waals	ICL3	K	276	-	s6h1	E	86	N.s6h1.03
Van-der-waals	ICL3	Q	281	-	s9s10	E	152	N.s9s10.07
Van-der-waals	TM5	R	215	5x72	S6	D	74	N.S6.04
Van-der-waals	TM6	K	282	6x24	s9s10	T	154	N.s9s10.09
Van-der-waals	TM3	I	125	3x54	s5s6	L	64	N.s5s6.05
Van-der-waals	ICL3	K	276	-	S5	F	50	N.S5.03
Van-der-waals	TM5	R	215	5x72	S6	R	72	N.S6.02
Van-der-waals	TM5	R	219	5x76	S6	V	77	N.S6.07
Van-der-waals	ICL3	S	277	-	s9s10	N	150	N.s9s10.02
Van-der-waals	TM5	A	208	5x65	s5s6	L	69	N.s5s6.10
Van-der-waals	ICL3	K	276	-	S6	L	80	N.S6.10
Van-der-waals	TM5	Q	216	5x73	s9s10	E	152	N.s9s10.07
Van-der-waals	ICL3	K	276	-	s9s10	P	151	N.s9s10.03
Van-der-waals	TM5	R	219	5x76	s9s10	E	152	N.s9s10.07
Van-der-waals	ICL2	A	128	34x50	s15s16	Y	241	C.s15s16.03
Van-der-waals	ICL3	R	279	-	s9s10	E	152	N.s9s10.07
Van-der-waals	ICL3	R	280	-	S5	M	52	N.S5.05
Van-der-waals	ICL2	A	132	34x54	s15s16	S	242	C.s15s16.04
Van-der-waals	ICL3	R	279	-	s9s10	T	154	N.s9s10.09
Van-der-waals	H8	N	351	8x47	s5s6	D	62	N.s5s6.03
Van-der-waals	ICL3	W	278	-	s9s10	E	152	N.s9s10.07
Van-der-waals	ICL3	E	275	-	s9s10	N	150	N.s9s10.02
Van-der-waals	ICL3	K	276	-	s9s10	N	150	N.s9s10.02
Van-der-waals	ICL3	W	278	-	s9s10	N	150	N.s9s10.02
Van-der-waals	TM6	T	286	6x28	s9s10	T	154	N.s9s10.09
Van-der-waals	TM2	A	58	2x39	s5s6	D	63	N.s5s6.04
Van-der-waals	ICL2	A	132	34x54	s5s6	R	61	N.s5s6.02
Van-der-waals	ICL3	S	277	-	s9s10	E	152	N.s9s10.07
Van-der-waals	ICL3	K	276	-	S6	Q	81	N.S6.11
Van-der-waals	ICL3	K	276	-	s9s10	E	152	N.s9s10.07
Van-der-waals	ICL3	R	280	-	S6	T	79	N.S6.09
Van-der-waals	ICL3	E	223	-	S6	T	79	N.S6.09
Van-der-waals	TM7	Y	347	7x53	s5s6	V	66	N.s5s6.07
Van-der-waals	TM6	I	283	6x25	s9s10	E	153	N.s9s10.08
Van-der-waals	ICL3	R	280	-	s9s10	E	153	N.s9s10.08
Van-der-waals	TM6	T	294	6x36	s5s6	V	66	N.s5s6.07
Van-der-waals	ICL1	R	52	12x48	s8s9	E	131	N.s8s9.05
Van-der-waals	TM6	I	283	6x25	S9	K	144	N.S9.08
Van-der-waals	ICL3	R	279	-	s9s10	E	149	N.s9s10.01
Van-der-waals	TM5	R	219	5x76	S5	M	52	N.S5.05

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Main reference

Arrestin-C - 5-HT1F receptor complex model Download Full