Arrestin-C - 5-HT2A receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
5-HT2A 62.9
Arrestin-C 81.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.1


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 180 34x50 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 P 180 34x50 s15s16 Y 241 C.s15s16.03
Polar C-term K 404 - s20c E 383 C.s20c.17
Hydrophobic C-term K 404 - s20c E 383 C.s20c.17
Van-der-waals C-term K 404 - s20c E 383 C.s20c.17
Hydrophobic ICL2 H 183 34x53 s5s6 L 64 N.s5s6.05
Polar ICL3 R 310 - S6 Y 76 N.S6.06
Hydrophobic ICL3 R 310 - S6 Y 76 N.S6.06
Van-der-waals ICL3 R 310 - S6 Y 76 N.S6.06
Hydrophobic TM3 I 177 3x54 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 I 181 34x51 S16 Y 246 C.S16.03
Van-der-waals ICL2 I 181 34x51 S16 Y 246 C.S16.03
Hydrophobic TM6 A 321 6x33 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 A 321 6x33 s5s6 L 69 N.s5s6.10
Polar TM6 S 314 6x26 S6 R 72 N.S6.02
Hydrophobic H8 N 384 8x47 s5s6 V 66 N.s5s6.07
Van-der-waals H8 N 384 8x47 s5s6 V 66 N.s5s6.07
Polar ICL2 H 182 34x52 S16 D 244 C.S16.01
Hydrophobic ICL2 H 182 34x52 S16 D 244 C.S16.01
Van-der-waals ICL2 H 182 34x52 S16 D 244 C.S16.01
Polar ICL2 R 185 34x55 S16 Y 246 C.S16.03
Aromatic ICL2 R 185 34x55 S16 Y 246 C.S16.03
Hydrophobic ICL2 R 185 34x55 S16 Y 246 C.S16.03
Van-der-waals ICL2 R 185 34x55 S16 Y 246 C.S16.03
Ionic ICL1 K 104 12x49 s20c E 383 C.s20c.17
Polar ICL1 K 104 12x49 s20c E 383 C.s20c.17
Hydrophobic ICL1 K 104 12x49 s20c E 383 C.s20c.17
Van-der-waals ICL1 K 104 12x49 s20c E 383 C.s20c.17
Polar ICL3 T 307 - S6 V 77 N.S6.07
Hydrophobic TM6 S 314 6x26 S6 K 73 N.S6.03
Van-der-waals TM6 S 314 6x26 S6 K 73 N.S6.03
Polar ICL3 R 310 - S6 V 77 N.S6.07
Hydrophobic ICL3 R 310 - S6 V 77 N.S6.07
Van-der-waals ICL3 R 310 - S6 V 77 N.S6.07
Polar TM6 E 318 6x30 s15s16 Y 241 C.s15s16.03
Polar ICL3 R 309 - s9s10 N 150 N.s9s10.02
Van-der-waals ICL3 R 310 - S6 Q 78 N.S6.08
Polar TM6 N 317 6x29 s5s6 T 70 N.s5s6.11
Hydrophobic TM6 N 317 6x29 s5s6 T 70 N.s5s6.11
Van-der-waals TM6 N 317 6x29 s5s6 T 70 N.s5s6.11
Hydrophobic TM2 N 107 2x37 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 N 107 2x37 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 L 113 2x43 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 L 113 2x43 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 A 176 3x53 S6 F 71 N.S6.01
Van-der-waals TM3 A 176 3x53 S6 F 71 N.S6.01
Hydrophobic ICL3 L 278 - s7s8 V 117 N.s7s8.03
Hydrophobic ICL3 Y 306 - S6 Y 76 N.S6.06
Hydrophobic TM3 A 176 3x53 s5s6 L 64 N.s5s6.05
Hydrophobic TM2 T 109 2x39 s5s6 I 67 N.s5s6.08
Ionic C-term K 404 - s20c E 386 C.s20c.20
Polar C-term K 404 - s20c E 386 C.s20c.20
Hydrophobic C-term K 404 - s20c E 386 C.s20c.20
Van-der-waals C-term K 404 - s20c E 386 C.s20c.20
Hydrophobic ICL3 R 310 - S6 D 74 N.S6.04
Van-der-waals ICL3 R 310 - S6 D 74 N.S6.04
Polar TM5 C 268 5x72 S6 K 73 N.S6.03
Hydrophobic TM5 C 268 5x72 S6 K 73 N.S6.03
Van-der-waals TM5 C 268 5x72 S6 K 73 N.S6.03
Van-der-waals ICL2 S 184 34x54 s8s9 G 134 N.s8s9.08
Ionic ICL3 R 309 - s9s10 E 152 N.s9s10.07
Polar ICL3 R 309 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL3 R 309 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 R 309 - s9s10 E 152 N.s9s10.07
Hydrophobic TM3 R 173 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 173 3x50 s5s6 I 67 N.s5s6.08
Polar ICL3 R 310 - S5 C 55 N.S5.08
Van-der-waals ICL3 R 310 - S5 C 55 N.S5.08
Polar H8 N 384 8x47 s5s6 E 65 N.s5s6.06
Hydrophobic H8 N 384 8x47 s5s6 E 65 N.s5s6.06
Van-der-waals H8 N 384 8x47 s5s6 E 65 N.s5s6.06
Hydrophobic ICL3 R 309 - S6 V 77 N.S6.07
Van-der-waals ICL3 R 309 - S6 V 77 N.S6.07
Polar ICL3 Y 306 - S6 T 79 N.S6.09
Hydrophobic ICL3 Y 306 - S6 T 79 N.S6.09
Van-der-waals ICL3 Y 306 - S6 T 79 N.S6.09
Hydrophobic ICL2 P 180 34x50 S6 F 71 N.S6.01
Hydrophobic ICL2 I 181 34x51 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 I 181 34x51 s15s16 S 242 C.s15s16.04
Polar TM6 S 314 6x26 s15s16 Y 241 C.s15s16.03
Ionic ICL2 R 185 34x55 s8s9 D 132 N.s8s9.06
Polar ICL2 R 185 34x55 s8s9 D 132 N.s8s9.06
Hydrophobic ICL2 R 185 34x55 s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 R 185 34x55 s8s9 D 132 N.s8s9.06
Hydrophobic ICL2 I 181 34x51 S5 F 57 N.S5.10
Hydrophobic ICL3 R 309 - s9s10 P 151 N.s9s10.03
Van-der-waals ICL3 R 309 - s9s10 P 151 N.s9s10.03
Hydrophobic ICL2 P 180 34x50 S5 Y 59 N.S5.12
Van-der-waals ICL2 P 180 34x50 S5 Y 59 N.S5.12
Polar ICL3 R 310 - S5 L 53 N.S5.06
Hydrophobic ICL3 R 310 - S5 L 53 N.S5.06
Van-der-waals ICL3 R 310 - S5 L 53 N.S5.06
Hydrophobic TM5 E 264 5x68 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 E 264 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic TM3 I 177 3x54 S6 F 71 N.S6.01
Van-der-waals ICL2 I 181 34x51 S16 D 244 C.S16.01
Polar ICL3 Y 306 - S6 V 77 N.S6.07
Hydrophobic ICL3 Y 306 - S6 V 77 N.S6.07
Van-der-waals ICL3 Y 306 - S6 V 77 N.S6.07
Polar ICL3 R 310 - S5 T 54 N.S5.07
Hydrophobic ICL3 R 310 - S5 T 54 N.S5.07
Van-der-waals ICL3 R 310 - S5 T 54 N.S5.07
Hydrophobic TM6 V 324 6x36 s5s6 I 67 N.s5s6.08
Hydrophobic TM2 N 110 2x40 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 N 110 2x40 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 Q 178 3x55 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 I 181 34x51 S15 V 238 C.S15.14
Van-der-waals ICL2 I 181 34x51 S15 V 238 C.S15.14
Hydrophobic ICL3 Y 306 - S6 Q 78 N.S6.08
Hydrophobic C-term L 406 - s20c A 382 C.s20c.15
Polar ICL3 T 311 - S6 D 74 N.S6.04
Hydrophobic H8 Y 387 8x50 s5s6 V 66 N.s5s6.07
Hydrophobic ICL3 T 307 - S6 Y 76 N.S6.06
Van-der-waals ICL3 T 307 - S6 Y 76 N.S6.06
Polar C-term K 404 - s20c A 382 C.s20c.15
Hydrophobic C-term K 404 - s20c A 382 C.s20c.15
Van-der-waals C-term K 404 - s20c A 382 C.s20c.15