Beta-arrestin-1 - 5-HT2B receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
5-HT2B 67.0
Beta-arrestin-1 80.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 16.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL3 Q 257 - s17s18 I 314 C.s17s18.40
Van-der-waals ICL3 Q 257 - s17s18 I 314 C.s17s18.40
Hydrophobic TM7 F 383 7x56 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 F 383 7x56 s5s6 V 70 N.s5s6.07
Polar TM6 N 318 6x29 s5s6 G 72 N.s5s6.09
Polar ICL3 K 310 - s9s10 E 156 N.s9s10.08
Polar ICL2 A 163 34x53 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 A 163 34x53 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 A 163 34x53 s5s6 R 65 N.s5s6.02
Hydrophobic ICL3 T 307 - S6 V 81 N.S6.07
Van-der-waals ICL3 T 307 - S6 V 81 N.S6.07
Polar ICL2 N 164 34x54 S5 Y 63 N.S5.12
Van-der-waals ICL2 N 164 34x54 S5 Y 63 N.S5.12
Hydrophobic TM2 Y 87 2x37 s8s9 T 136 N.s8s9.07
Van-der-waals TM2 Y 87 2x37 s8s9 T 136 N.s8s9.07
Polar TM6 A 322 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 A 322 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic ICL3 W 261 - S6 V 81 N.S6.07
Van-der-waals ICL3 W 261 - S6 V 81 N.S6.07
Hydrophobic ICL3 I 308 - S6 D 78 N.S6.04
Ionic ICL1 K 84 12x49 s20c E 407 C.s20c.17
Polar ICL1 K 84 12x49 s20c E 407 C.s20c.17
Van-der-waals ICL1 K 84 12x49 s20c E 407 C.s20c.17
Polar ICL3 K 311 - S5 T 58 N.S5.07
Van-der-waals ICL3 K 311 - S5 T 58 N.S5.07
Hydrophobic TM3 A 156 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic TM6 L 326 6x37 s5s6 L 71 N.s5s6.08
Polar ICL2 Q 165 34x55 S16 Q 248 C.S16.02
Hydrophobic ICL3 W 261 - S6 A 82 N.S6.08
Van-der-waals ICL3 W 261 - S6 A 82 N.S6.08
Polar TM2 Y 87 2x37 s5s6 E 66 N.s5s6.03
Hydrophobic TM2 Y 87 2x37 s5s6 E 66 N.s5s6.03
Van-der-waals TM2 Y 87 2x37 s5s6 E 66 N.s5s6.03
Hydrophobic ICL3 W 261 - S6 F 80 N.S6.06
Van-der-waals ICL3 W 261 - S6 F 80 N.S6.06
Polar ICL2 N 164 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 N 164 34x54 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 N 164 34x54 s5s6 R 65 N.s5s6.02
Polar ICL3 K 310 - s9s10 E 155 N.s9s10.07
Hydrophobic ICL3 K 310 - s9s10 E 155 N.s9s10.07
Van-der-waals ICL3 K 310 - s9s10 E 155 N.s9s10.07
Hydrophobic ICL2 P 160 34x50 s15s16 N 245 C.s15s16.04
Hydrophobic ICL3 I 308 - S6 F 80 N.S6.06
Hydrophobic TM6 E 319 6x30 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 K 159 3x56 s15s16 N 245 C.s15s16.04
Polar ICL3 Q 257 - s17s18 N 311 C.s17s18.37
Hydrophobic ICL3 Q 257 - s17s18 N 311 C.s17s18.37
Van-der-waals ICL3 Q 257 - s17s18 N 311 C.s17s18.37
Polar TM6 N 318 6x29 s5s6 T 74 N.s5s6.11
Van-der-waals TM6 N 318 6x29 s5s6 T 74 N.s5s6.11
Ionic ICL3 K 311 - S6 D 78 N.S6.04
Polar ICL3 K 311 - S6 D 78 N.S6.04
Hydrophobic ICL3 K 311 - S6 D 78 N.S6.04
Van-der-waals ICL3 K 311 - S6 D 78 N.S6.04
Ionic TM5 K 254 5x75 s17s18 E 313 C.s17s18.39
Polar TM5 K 254 5x75 s17s18 E 313 C.s17s18.39
Van-der-waals TM5 K 254 5x75 s17s18 E 313 C.s17s18.39
Polar ICL2 N 167 34x57 s5s6 D 67 N.s5s6.04
Hydrophobic TM3 I 157 3x54 s5s6 L 71 N.s5s6.08
Hydrophobic ICL3 K 311 - S6 R 76 N.S6.02
Van-der-waals ICL3 K 311 - S6 R 76 N.S6.02
Hydrophobic TM6 V 325 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 A 322 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 322 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 N 318 6x29 s5s6 L 73 N.s5s6.10
Hydrophobic TM7 Y 380 7x53 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 Y 380 7x53 s5s6 V 70 N.s5s6.07
Polar ICL2 P 160 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 P 160 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 160 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL3 I 308 - S6 L 79 N.S6.05
Ionic TM4 R 169 4x39 s8s9 E 134 N.s8s9.05
Polar TM4 R 169 4x39 s8s9 E 134 N.s8s9.05
Hydrophobic TM4 R 169 4x39 s8s9 E 134 N.s8s9.05
Van-der-waals TM4 R 169 4x39 s8s9 E 134 N.s8s9.05
Hydrophobic ICL3 T 307 - s9s10 L 154 N.s9s10.03
Hydrophobic ICL2 I 161 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 I 161 34x51 S16 A 247 C.S16.01
Polar ICL3 T 307 - S6 N 83 N.S6.09
Hydrophobic ICL3 T 307 - S6 N 83 N.S6.09
Van-der-waals ICL3 T 307 - S6 N 83 N.S6.09
Polar ICL2 I 161 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 I 161 34x51 S5 Y 63 N.S5.12
Van-der-waals ICL2 I 161 34x51 S5 Y 63 N.S5.12
Polar ICL3 K 310 - s9s10 L 154 N.s9s10.03
Hydrophobic ICL3 K 310 - s9s10 L 154 N.s9s10.03
Van-der-waals ICL3 K 310 - s9s10 L 154 N.s9s10.03
Hydrophobic TM5 L 244 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 I 161 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 I 161 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 I 157 3x54 s5s6 L 68 N.s5s6.05
Polar TM6 T 315 6x26 S6 R 76 N.S6.02
Van-der-waals TM6 T 315 6x26 S6 R 76 N.S6.02
Ionic H8 K 385 8x48 s20c E 407 C.s20c.17
Hydrophobic TM5 V 251 5x72 s15s16 F 244 C.s15s16.03
Hydrophobic TM3 R 153 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 E 319 6x30 S6 F 75 N.S6.01
Van-der-waals TM6 E 319 6x30 S6 F 75 N.S6.01
Hydrophobic ICL3 I 308 - S6 V 81 N.S6.07
Van-der-waals ICL3 I 308 - S6 V 81 N.S6.07
Hydrophobic TM3 R 153 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 153 3x50 s5s6 V 70 N.s5s6.07
Ionic ICL1 K 84 12x49 s20c E 404 C.s20c.14
Polar ICL1 K 84 12x49 s20c E 404 C.s20c.14
Hydrophobic ICL1 K 84 12x49 s20c E 404 C.s20c.14
Van-der-waals ICL1 K 84 12x49 s20c E 404 C.s20c.14
Polar ICL2 Q 162 34x52 s15s16 T 246 C.s15s16.05
Van-der-waals ICL2 Q 162 34x52 s15s16 T 246 C.s15s16.05
Hydrophobic TM2 Y 87 2x37 s5s6 D 67 N.s5s6.04
Polar ICL2 N 167 34x57 s17s18 R 285 C.s17s18.11
Hydrophobic H8 N 384 8x47 s5s6 V 70 N.s5s6.07
Polar ICL2 Q 165 34x55 S16 Y 249 C.S16.03
Hydrophobic ICL2 Q 165 34x55 S16 Y 249 C.S16.03
Van-der-waals ICL2 Q 165 34x55 S16 Y 249 C.S16.03
Hydrophobic TM2 T 89 2x39 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 T 89 2x39 s5s6 D 67 N.s5s6.04
Hydrophobic TM3 I 157 3x54 s5s6 L 73 N.s5s6.10
Polar ICL2 I 161 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 I 161 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 I 161 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 N 167 34x57 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 N 167 34x57 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 Q 162 34x52 S16 A 247 C.S16.01
Hydrophobic ICL2 I 161 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 I 161 34x51 S15 I 241 C.S15.14
Hydrophobic TM5 K 247 5x68 S6 F 75 N.S6.01
Van-der-waals TM5 K 247 5x68 S6 F 75 N.S6.01