S-arrestin - 5-HT2B receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
5-HT2B 67.2
S-arrestin 81.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 15.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar H8 N 384 8x47 s5s6 V 78 N.s5s6.07
Van-der-waals H8 N 384 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic ICL3 L 259 - s17s18 V 324 C.s17s18.40
Hydrophobic TM7 F 383 7x56 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 F 383 7x56 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 I 161 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 I 161 34x51 S16 Y 259 C.S16.03
Polar ICL3 T 307 - S6 F 89 N.S6.07
Hydrophobic ICL3 T 307 - S6 F 89 N.S6.07
Van-der-waals ICL3 T 307 - S6 F 89 N.S6.07
Polar C-term V 481 - S11 Q 199 C.S11.06
Van-der-waals C-term V 481 - S11 Q 199 C.S11.06
Ionic C-term R 409 - s20c E 392 C.s20c.11
Ionic ICL3 K 310 - s9s10 D 162 N.s9s10.04
Polar ICL3 K 310 - s9s10 D 162 N.s9s10.04
Van-der-waals ICL3 K 310 - s9s10 D 162 N.s9s10.04
Hydrophobic ICL3 L 259 - s7s8 Y 129 N.s7s8.05
Van-der-waals ICL3 L 259 - s7s8 Y 129 N.s7s8.05
Polar ICL2 N 164 34x54 s5s6 Q 73 N.s5s6.02
Hydrophobic ICL2 N 164 34x54 s5s6 Q 73 N.s5s6.02
Van-der-waals ICL2 N 164 34x54 s5s6 Q 73 N.s5s6.02
Hydrophobic TM6 N 318 6x29 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 N 318 6x29 s5s6 L 81 N.s5s6.10
Hydrophobic TM7 V 379 7x52 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 V 379 7x52 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 A 156 3x53 s5s6 I 76 N.s5s6.05
Hydrophobic TM6 T 315 6x26 s15s16 Y 254 C.s15s16.03
Van-der-waals TM6 T 315 6x26 s15s16 Y 254 C.s15s16.03
Polar TM2 Y 87 2x37 s5s6 D 75 N.s5s6.04
Hydrophobic TM2 Y 87 2x37 s5s6 D 75 N.s5s6.04
Van-der-waals TM2 Y 87 2x37 s5s6 D 75 N.s5s6.04
Hydrophobic ICL2 I 161 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 I 161 34x51 S15 V 251 C.S15.14
Polar C-term S 479 - S11 W 198 C.S11.05
Hydrophobic C-term S 479 - S11 W 198 C.S11.05
Van-der-waals C-term S 479 - S11 W 198 C.S11.05
Hydrophobic TM6 A 322 6x33 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 A 322 6x33 s5s6 I 79 N.s5s6.08
Polar ICL2 Q 165 34x55 s17s18 R 295 C.s17s18.11
Hydrophobic ICL2 Q 165 34x55 s17s18 R 295 C.s17s18.11
Van-der-waals ICL2 Q 165 34x55 s17s18 R 295 C.s17s18.11
Hydrophobic TM5 K 247 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL2 I 161 34x51 S8 L 136 N.S8.03
Hydrophobic TM3 I 157 3x54 S6 F 83 N.S6.01
Polar TM6 E 319 6x30 S5 Y 71 N.S5.12
Polar TM6 T 315 6x26 S6 R 84 N.S6.02
Hydrophobic ICL3 P 256 - s17s18 V 324 C.s17s18.40
Van-der-waals ICL3 P 256 - s17s18 V 324 C.s17s18.40
Polar TM6 N 318 6x29 s5s6 T 82 N.s5s6.11
Van-der-waals TM6 N 318 6x29 s5s6 T 82 N.s5s6.11
Hydrophobic C-term V 478 - S11 Q 199 C.S11.06
Van-der-waals C-term V 478 - S11 Q 199 C.S11.06
Hydrophobic ICL3 T 305 - S6 Y 88 N.S6.06
Van-der-waals ICL3 T 305 - S6 Y 88 N.S6.06
Polar ICL2 Q 162 34x52 S16 Y 259 C.S16.03
Hydrophobic ICL2 Q 162 34x52 S16 Y 259 C.S16.03
Van-der-waals ICL2 Q 162 34x52 S16 Y 259 C.S16.03
Hydrophobic ICL2 I 161 34x51 S9 C 147 N.S9.01
Van-der-waals ICL2 I 161 34x51 S9 C 147 N.S9.01
Hydrophobic ICL3 I 308 - S6 Y 88 N.S6.06
Hydrophobic TM6 T 315 6x26 S6 R 85 N.S6.03
Hydrophobic TM6 E 319 6x30 s15s16 Y 254 C.s15s16.03
Van-der-waals TM6 E 319 6x30 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL3 K 311 - S6 F 89 N.S6.07
Van-der-waals ICL3 K 311 - S6 F 89 N.S6.07
Hydrophobic ICL3 I 308 - S6 L 87 N.S6.05
Van-der-waals ICL3 I 308 - S6 L 87 N.S6.05
Polar C-term S 479 - S11 A 197 C.S11.04
Van-der-waals C-term S 479 - S11 A 197 C.S11.04
Hydrophobic TM5 K 254 5x75 s17s18 T 323 C.s17s18.39
Hydrophobic TM5 V 251 5x72 s15s16 Y 254 C.s15s16.03
Ionic ICL3 K 311 - S6 D 86 N.S6.04
Polar ICL3 K 311 - S6 D 86 N.S6.04
Hydrophobic ICL3 K 311 - S6 D 86 N.S6.04
Van-der-waals ICL3 K 311 - S6 D 86 N.S6.04
Hydrophobic ICL2 Q 165 34x55 S16 Y 259 C.S16.03
Hydrophobic ICL2 Q 165 34x55 s17s18 G 296 C.s17s18.12
Van-der-waals ICL2 Q 165 34x55 s17s18 G 296 C.s17s18.12
Hydrophobic C-term V 481 - s11s12 F 200 C.s11s12.01
Van-der-waals C-term V 481 - s11s12 F 200 C.s11s12.01
Hydrophobic TM3 R 153 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 153 3x50 s5s6 V 78 N.s5s6.07
Polar TM5 V 251 5x72 S6 R 85 N.S6.03
Hydrophobic TM5 V 251 5x72 S6 R 85 N.S6.03
Polar TM2 T 89 2x39 s5s6 I 76 N.s5s6.05
Hydrophobic TM6 V 325 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM7 Y 380 7x53 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 Y 380 7x53 s5s6 V 78 N.s5s6.07
Polar TM5 K 247 5x68 S5 Y 71 N.S5.12
Hydrophobic TM3 R 153 3x50 s5s6 I 79 N.s5s6.08
Polar C-term V 481 - s11s12 F 201 C.s11s12.02
Van-der-waals C-term V 481 - s11s12 F 201 C.s11s12.02
Hydrophobic TM6 L 326 6x37 s5s6 I 79 N.s5s6.08
Polar C-term Y 480 - S11 Q 199 C.S11.06
Hydrophobic C-term Y 480 - S11 Q 199 C.S11.06
Van-der-waals C-term Y 480 - S11 Q 199 C.S11.06
Hydrophobic TM2 L 93 2x43 s5s6 V 78 N.s5s6.07
Hydrophobic TM7 F 383 7x56 s5s6 I 79 N.s5s6.08
Polar TM6 Q 314 6x25 s9s10 D 166 N.s9s10.08
Ionic ICL3 K 311 - s9s10 E 165 N.s9s10.07
Polar ICL3 K 311 - s9s10 E 165 N.s9s10.07
Hydrophobic ICL3 K 311 - s9s10 E 165 N.s9s10.07
Van-der-waals ICL3 K 311 - s9s10 E 165 N.s9s10.07
Hydrophobic TM6 A 322 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 A 322 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic ICL3 I 308 - S6 F 89 N.S6.07
Ionic TM3 R 153 3x50 s5s6 D 77 N.s5s6.06
Polar TM3 R 153 3x50 s5s6 D 77 N.s5s6.06
Hydrophobic TM3 R 153 3x50 s5s6 D 77 N.s5s6.06
Van-der-waals TM3 R 153 3x50 s5s6 D 77 N.s5s6.06
Hydrophobic C-term V 481 - S11 W 198 C.S11.05
Polar C-term S 479 - S11 Q 199 C.S11.06
Van-der-waals C-term S 479 - S11 Q 199 C.S11.06
Hydrophobic ICL2 P 160 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL3 T 305 - s7s8 Y 129 N.s7s8.05