Beta-arrestin-2 - 5-HT2C receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
5-HT2C 72.6
Beta-arrestin-2 80.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 V 312 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 I 160 34x51 S8 L 130 N.S8.03
Van-der-waals ICL2 I 160 34x51 S8 L 130 N.S8.03
Polar TM6 N 305 6x29 s5s6 S 75 N.s5s6.11
Hydrophobic TM6 E 306 6x30 s5s6 L 74 N.s5s6.10
Polar ICL3 T 299 - S6 D 79 N.S6.04
Van-der-waals ICL3 T 299 - S6 D 79 N.S6.04
Hydrophobic TM6 E 306 6x30 S6 F 76 N.S6.01
Van-der-waals TM6 E 306 6x30 S6 F 76 N.S6.01
Van-der-waals TM7 F 371 7x56 s5s6 V 71 N.s5s6.07
Polar ICL2 P 159 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 159 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 159 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 I 160 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 I 160 34x51 S15 I 242 C.S15.14
Polar ICL2 S 163 34x54 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 S 163 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 P 159 34x50 s5s6 L 69 N.s5s6.05
Hydrophobic TM5 L 248 5x72 S6 K 78 N.S6.03
Hydrophobic TM4 S 167 4x38 s8s9 E 135 N.s8s9.05
Hydrophobic TM3 A 155 3x53 s5s6 L 69 N.s5s6.05
Polar C-term Q 437 - S16 K 251 C.S16.04
Hydrophobic TM3 I 156 3x54 s5s6 L 72 N.s5s6.08
Ionic ICL1 K 83 12x49 s5s6 E 67 N.s5s6.03
Polar ICL1 K 83 12x49 s5s6 E 67 N.s5s6.03
Hydrophobic TM3 R 152 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 N 305 6x29 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 R 164 34x55 S8 L 130 N.S8.03
Van-der-waals ICL2 R 164 34x55 S8 L 130 N.S8.03
Hydrophobic TM3 I 156 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic TM2 T 88 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 P 159 34x50 s15s16 S 246 C.s15s16.04
Polar TM2 N 86 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 N 86 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 N 86 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM5 Q 244 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 N 166 34x57 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 N 166 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic ICL3 P 296 - S6 D 79 N.S6.04
Van-der-waals ICL3 P 296 - S6 D 79 N.S6.04
Polar ICL3 R 297 - s9s10 L 155 N.s9s10.03
Van-der-waals ICL3 R 297 - s9s10 L 155 N.s9s10.03
Polar TM4 R 168 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 R 168 4x39 s8s9 E 135 N.s8s9.05
Polar ICL3 G 298 - S6 D 79 N.S6.04
Hydrophobic ICL3 G 298 - S6 D 79 N.S6.04
Van-der-waals ICL3 G 298 - S6 D 79 N.S6.04
Hydrophobic H8 N 372 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM7 Y 368 7x53 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 Y 368 7x53 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 L 248 5x72 S6 F 76 N.S6.01
Van-der-waals TM5 L 248 5x72 S6 F 76 N.S6.01
Polar ICL2 S 163 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 S 163 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 S 163 34x54 s5s6 R 66 N.s5s6.02
Polar ICL3 H 252 - S6 D 79 N.S6.04
Hydrophobic ICL3 H 252 - S6 D 79 N.S6.04
Van-der-waals ICL3 H 252 - S6 D 79 N.S6.04
Hydrophobic TM6 A 309 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic C-term M 436 - S16 Y 250 C.S16.03
Hydrophobic ICL3 P 296 - S6 I 82 N.S6.07
Van-der-waals ICL3 P 296 - S6 I 82 N.S6.07
Hydrophobic C-term I 434 - S16 C 252 C.S16.05
Polar ICL2 I 160 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 I 160 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 I 160 34x51 S5 Y 64 N.S5.12
Polar ICL3 R 297 - s9s10 E 157 N.s9s10.08
Hydrophobic ICL3 R 297 - s9s10 E 157 N.s9s10.08
Van-der-waals ICL3 R 297 - s9s10 E 157 N.s9s10.08
Hydrophobic ICL2 I 160 34x51 S9 C 141 N.S9.01
Polar ICL2 E 161 34x52 S16 Y 250 C.S16.03
Van-der-waals ICL2 E 161 34x52 S16 Y 250 C.S16.03
Aromatic ICL2 R 164 34x55 S16 Y 250 C.S16.03
Hydrophobic ICL2 R 164 34x55 S16 Y 250 C.S16.03
Van-der-waals ICL2 R 164 34x55 S16 Y 250 C.S16.03
Aromatic ICL1 K 83 12x49 s20c Y 404 C.s20c.14
Hydrophobic ICL1 K 83 12x49 s20c Y 404 C.s20c.14
Van-der-waals ICL1 K 83 12x49 s20c Y 404 C.s20c.14
Hydrophobic TM5 L 241 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 L 248 5x72 s15s16 F 245 C.s15s16.03
Polar ICL3 R 297 - s9s10 E 156 N.s9s10.07
Hydrophobic ICL3 R 297 - s9s10 E 156 N.s9s10.07
Van-der-waals ICL3 R 297 - s9s10 E 156 N.s9s10.07
Hydrophobic TM6 A 302 6x26 S6 R 77 N.S6.02
Van-der-waals TM6 A 302 6x26 S6 R 77 N.S6.02
Hydrophobic TM6 A 309 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 309 6x33 s5s6 L 74 N.s5s6.10
Aromatic ICL3 H 252 - S6 K 78 N.S6.03
Hydrophobic C-term I 434 - S16 K 251 C.S16.04
Van-der-waals C-term I 434 - S16 K 251 C.S16.04
Polar ICL2 R 164 34x55 s17s18 G 287 C.s17s18.12
Hydrophobic ICL2 R 164 34x55 s17s18 G 287 C.s17s18.12
Van-der-waals ICL2 R 164 34x55 s17s18 G 287 C.s17s18.12
Polar ICL2 I 160 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 I 160 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 I 160 34x51 S16 Y 250 C.S16.03
Hydrophobic TM6 L 313 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 313 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 I 156 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 I 156 3x54 s5s6 L 74 N.s5s6.10