S-arrestin - 5-HT4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
5-HT4 73.9
S-arrestin 81.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 I 264 6x40 s5s6 I 79 N.s5s6.08
Hydrophobic TM5 L 229 5x75 s15s16 L 253 C.s15s16.02
Hydrophobic TM3 R 118 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 118 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 L 127 34x51 S8 L 136 N.S8.03
Van-der-waals ICL2 L 127 34x51 S8 L 136 N.S8.03
Hydrophobic ICL2 L 127 34x51 S5 Y 71 N.S5.12
Hydrophobic TM5 I 215 5x61 s5s6 I 79 N.s5s6.08
Hydrophobic ICL3 H 246 - S6 Y 88 N.S6.06
Hydrophobic ICL2 Y 129 34x53 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 Y 129 34x53 s8s9 K 145 N.s8s9.09
Hydrophobic C-term R 336 - s20c R 398 C.s20c.17
Van-der-waals C-term R 336 - s20c R 398 C.s20c.17
Hydrophobic TM5 A 219 5x65 s5s6 L 81 N.s5s6.10
Van-der-waals TM7 L 315 7x56 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 A 121 3x53 s5s6 I 76 N.s5s6.05
Ionic H8 K 317 8x48 s9s10 D 166 N.s9s10.08
Polar H8 K 317 8x48 s9s10 D 166 N.s9s10.08
Hydrophobic H8 N 316 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 N 316 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic TM5 Y 212 5x58 s5s6 I 79 N.s5s6.08
Hydrophobic TM2 I 53 2x37 s5s6 D 75 N.s5s6.04
Van-der-waals TM2 I 53 2x37 s5s6 D 75 N.s5s6.04
Hydrophobic TM5 I 215 5x61 s5s6 L 81 N.s5s6.10
Hydrophobic TM3 I 122 3x54 s5s6 L 81 N.s5s6.10
Hydrophobic TM5 A 232 5x78 s7s8 Y 129 N.s7s8.05
Ionic ICL1 R 48 12x48 s20c E 394 C.s20c.13
Polar ICL1 R 48 12x48 s20c E 394 C.s20c.13
Van-der-waals ICL1 R 48 12x48 s20c E 394 C.s20c.13
Polar ICL2 P 126 34x50 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 P 126 34x50 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 P 126 34x50 s8s9 K 145 N.s8s9.09
Hydrophobic C-term I 339 - s20c E 394 C.s20c.13
Polar ICL2 V 128 34x52 S16 Y 259 C.S16.03
Hydrophobic ICL2 V 128 34x52 S16 Y 259 C.S16.03
Van-der-waals ICL2 V 128 34x52 S16 Y 259 C.S16.03
Polar TM6 T 260 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 T 260 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 T 260 6x36 s5s6 I 79 N.s5s6.08
Polar TM5 H 222 5x68 S6 R 85 N.S6.03
Hydrophobic TM5 H 222 5x68 S6 R 85 N.S6.03
Van-der-waals TM5 H 222 5x68 S6 R 85 N.S6.03
Hydrophobic TM5 G 233 5x79 s7s8 Y 129 N.s7s8.05
Van-der-waals TM5 G 233 5x79 s7s8 Y 129 N.s7s8.05
Polar ICL2 R 130 34x54 s5s6 Q 73 N.s5s6.02
Polar ICL2 Q 125 - S16 D 257 C.S16.01
Hydrophobic ICL2 Q 125 - S16 D 257 C.S16.01
Van-der-waals ICL2 Q 125 - S16 D 257 C.S16.01
Polar TM5 Q 225 5x71 s15s16 Y 254 C.s15s16.03
Polar TM5 H 222 5x68 s15s16 Y 254 C.s15s16.03
Aromatic TM5 H 222 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 H 222 5x68 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 H 222 5x68 s15s16 Y 254 C.s15s16.03
Ionic ICL1 K 52 12x52 s20c E 395 C.s20c.14
Polar ICL1 K 52 12x52 s20c E 395 C.s20c.14
Van-der-waals ICL1 K 52 12x52 s20c E 395 C.s20c.14
Polar TM5 Q 230 5x76 S6 D 86 N.S6.04
Van-der-waals TM5 Q 230 5x76 S6 D 86 N.S6.04
Hydrophobic TM5 L 229 5x75 s17s18 V 324 C.s17s18.40
Van-der-waals TM5 L 229 5x75 s17s18 V 324 C.s17s18.40
Polar TM5 A 223 5x69 S6 R 85 N.S6.03
Hydrophobic TM5 A 223 5x69 S6 R 85 N.S6.03
Van-der-waals TM5 A 223 5x69 S6 R 85 N.S6.03
Hydrophobic TM5 I 226 5x72 S6 L 87 N.S6.05
Van-der-waals TM5 I 226 5x72 S6 L 87 N.S6.05
Hydrophobic TM5 L 229 5x75 s7s8 Y 129 N.s7s8.05
Polar ICL3 H 246 - S6 F 89 N.S6.07
Hydrophobic ICL3 H 246 - S6 F 89 N.S6.07
Van-der-waals ICL3 H 246 - S6 F 89 N.S6.07
Hydrophobic ICL2 L 127 34x51 S9 C 147 N.S9.01
Van-der-waals ICL2 L 127 34x51 S9 C 147 N.S9.01
Hydrophobic TM3 R 118 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 118 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM5 I 226 5x72 s15s16 L 253 C.s15s16.02
Van-der-waals TM5 I 226 5x72 s15s16 L 253 C.s15s16.02
Hydrophobic H8 N 316 8x47 s5s6 V 78 N.s5s6.07
Van-der-waals H8 N 316 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 I 122 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 I 122 3x54 S6 F 83 N.S6.01
Hydrophobic TM5 I 226 5x72 S6 R 85 N.S6.03
Van-der-waals TM5 I 226 5x72 S6 R 85 N.S6.03
Ionic TM6 H 249 6x25 S6 D 86 N.S6.04
Polar ICL2 P 126 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 P 126 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 126 34x50 S5 Y 71 N.S5.12
Hydrophobic TM6 A 257 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 A 257 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 L 127 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 L 127 34x51 S16 Y 259 C.S16.03
Hydrophobic TM5 Q 230 5x76 S6 L 87 N.S6.05
Van-der-waals TM5 Q 230 5x76 S6 L 87 N.S6.05
Polar H8 N 316 8x47 s5s6 D 75 N.s5s6.04
Van-der-waals H8 N 316 8x47 s5s6 D 75 N.s5s6.04
Hydrophobic ICL2 L 127 34x51 S15 V 251 C.S15.14
Hydrophobic TM6 L 261 6x37 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 L 261 6x37 s5s6 I 79 N.s5s6.08
Polar TM6 K 256 6x32 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 K 256 6x32 s5s6 G 80 N.s5s6.09
Hydrophobic ICL2 R 130 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 R 130 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic TM5 L 229 5x75 S6 L 87 N.S6.05
Ionic ICL2 R 130 34x54 s8s9 D 142 N.s8s9.06
Polar ICL2 R 130 34x54 s8s9 D 142 N.s8s9.06
Hydrophobic ICL2 R 130 34x54 s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 R 130 34x54 s8s9 D 142 N.s8s9.06
Ionic TM6 R 252 6x28 s9s10 E 164 N.s9s10.06
Polar TM6 R 252 6x28 s9s10 E 164 N.s9s10.06
Hydrophobic TM6 R 252 6x28 s9s10 E 164 N.s9s10.06
Van-der-waals TM6 R 252 6x28 s9s10 E 164 N.s9s10.06
Hydrophobic ICL2 P 126 34x50 s5s6 G 72 N.s5s6.01
Van-der-waals ICL2 P 126 34x50 s5s6 G 72 N.s5s6.01
Hydrophobic TM5 I 226 5x72 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 I 226 5x72 s15s16 Y 254 C.s15s16.03
Polar TM3 R 118 3x50 s5s6 I 76 N.s5s6.05
Hydrophobic TM3 R 118 3x50 s5s6 I 76 N.s5s6.05
Van-der-waals TM3 R 118 3x50 s5s6 I 76 N.s5s6.05
Polar ICL2 R 130 34x54 s8s9 Q 141 N.s8s9.05
Van-der-waals ICL2 R 130 34x54 s8s9 Q 141 N.s8s9.05
Hydrophobic TM3 I 122 3x54 s5s6 I 79 N.s5s6.08
Polar ICL2 L 127 34x51 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 L 127 34x51 s8s9 K 145 N.s8s9.09
Hydrophobic TM3 A 121 3x53 S6 F 83 N.S6.01
Van-der-waals TM3 A 121 3x53 S6 F 83 N.S6.01
Polar ICL3 E 237 - S6 Y 88 N.S6.06