S-arrestin - 5-HT5A receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
5-HT5A 77.8
S-arrestin 81.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL3 V 239 - s17s18 V 324 C.s17s18.40
Van-der-waals ICL3 V 239 - s17s18 V 324 C.s17s18.40
Hydrophobic TM5 A 227 5x65 s5s6 L 81 N.s5s6.10
Hydrophobic TM5 I 223 5x61 s5s6 I 79 N.s5s6.08
Van-der-waals TM5 I 223 5x61 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 H 146 34x50 S9 C 147 N.S9.01
Polar TM4 R 152 4x36 s8s9 Q 141 N.s8s9.05
Polar ICL3 V 239 - s7s8 Y 129 N.s7s8.05
Hydrophobic ICL3 V 239 - s7s8 Y 129 N.s7s8.05
Van-der-waals ICL3 V 239 - s7s8 Y 129 N.s7s8.05
Ionic ICL2 H 146 34x50 S16 D 257 C.S16.01
Polar TM4 L 151 4x35 s8s9 D 142 N.s8s9.06
Hydrophobic TM4 L 151 4x35 s8s9 D 142 N.s8s9.06
Van-der-waals TM4 L 151 4x35 s8s9 D 142 N.s8s9.06
Polar TM5 R 234 5x72 S6 L 87 N.S6.05
Hydrophobic TM5 R 234 5x72 S6 L 87 N.S6.05
Van-der-waals TM5 R 234 5x72 S6 L 87 N.S6.05
Hydrophobic ICL2 T 150 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL3 P 241 - s7s8 Y 129 N.s7s8.05
Van-der-waals ICL3 P 241 - s7s8 Y 129 N.s7s8.05
Hydrophobic ICL2 H 146 34x50 S16 Y 259 C.S16.03
Van-der-waals ICL2 H 146 34x50 S16 Y 259 C.S16.03
Hydrophobic TM6 W 275 6x25 S6 D 86 N.S6.04
Van-der-waals TM6 W 275 6x25 S6 D 86 N.S6.04
Polar TM3 I 143 3x54 S5 Y 71 N.S5.12
Hydrophobic TM3 I 143 3x54 S5 Y 71 N.S5.12
Van-der-waals TM3 I 143 3x54 S5 Y 71 N.S5.12
Hydrophobic ICL2 M 147 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 M 147 34x51 S16 Y 259 C.S16.03
Polar TM5 N 237 5x75 s17s18 D 321 C.s17s18.37
Hydrophobic TM5 N 237 5x75 s17s18 D 321 C.s17s18.37
Van-der-waals TM5 N 237 5x75 s17s18 D 321 C.s17s18.37
Hydrophobic ICL2 M 147 34x51 s17s18 G 296 C.s17s18.12
Van-der-waals ICL2 M 147 34x51 s17s18 G 296 C.s17s18.12
Hydrophobic TM3 S 142 3x53 s5s6 I 76 N.s5s6.05
Van-der-waals TM3 S 142 3x53 s5s6 I 76 N.s5s6.05
Polar TM5 N 237 5x75 s17s18 T 323 C.s17s18.39
Van-der-waals TM5 N 237 5x75 s17s18 T 323 C.s17s18.39
Ionic TM2 R 73 2x37 s20c E 394 C.s20c.13
Polar TM5 R 230 5x68 S5 Y 71 N.S5.12
Aromatic TM5 R 230 5x68 S5 Y 71 N.S5.12
Hydrophobic TM5 R 230 5x68 S5 Y 71 N.S5.12
Hydrophobic TM5 Y 220 5x58 s5s6 I 79 N.s5s6.08
Polar TM4 R 154 4x38 s5s6 Q 73 N.s5s6.02
Van-der-waals TM4 R 154 4x38 s5s6 Q 73 N.s5s6.02
Polar TM5 R 230 5x68 S6 R 85 N.S6.03
Van-der-waals TM5 R 230 5x68 S6 R 85 N.S6.03
Hydrophobic TM2 R 73 2x37 s20c R 398 C.s20c.17
Polar ICL2 Y 149 34x53 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 Y 149 34x53 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 Y 149 34x53 s8s9 K 145 N.s8s9.09
Hydrophobic ICL3 V 239 - s17s18 I 320 C.s17s18.36
Hydrophobic ICL2 M 147 34x51 S8 L 136 N.S8.03
Van-der-waals ICL2 M 147 34x51 S8 L 136 N.S8.03
Polar H8 N 351 8x56 s20c E 405 C.s20c.24
Van-der-waals H8 N 351 8x56 s20c E 405 C.s20c.24
Polar ICL2 H 146 34x50 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 H 146 34x50 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 H 146 34x50 s8s9 K 145 N.s8s9.09
Hydrophobic TM6 V 287 6x37 s5s6 I 79 N.s5s6.08
Polar TM5 R 234 5x72 S6 D 86 N.S6.04
Hydrophobic TM5 R 234 5x72 S6 D 86 N.S6.04
Van-der-waals TM5 R 234 5x72 S6 D 86 N.S6.04
Polar ICL2 T 150 34x54 s8s9 D 142 N.s8s9.06
Hydrophobic ICL2 T 150 34x54 s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 T 150 34x54 s8s9 D 142 N.s8s9.06
Polar ICL2 H 146 34x50 S5 Y 71 N.S5.12
Aromatic ICL2 H 146 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 H 146 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 H 146 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL3 V 239 - s17s18 D 321 C.s17s18.37
Van-der-waals ICL3 V 239 - s17s18 D 321 C.s17s18.37
Hydrophobic TM5 R 234 5x72 S6 R 85 N.S6.03
Van-der-waals TM5 R 234 5x72 S6 R 85 N.S6.03
Ionic C-term R 355 - s20c E 405 C.s20c.24
Polar C-term R 355 - s20c E 405 C.s20c.24
Hydrophobic C-term R 355 - s20c E 405 C.s20c.24
Van-der-waals C-term R 355 - s20c E 405 C.s20c.24
Hydrophobic TM5 N 237 5x75 s17s18 V 324 C.s17s18.40
Van-der-waals TM5 N 237 5x75 s17s18 V 324 C.s17s18.40
Hydrophobic TM3 I 143 3x54 s5s6 I 76 N.s5s6.05
Hydrophobic TM6 M 286 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 M 286 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM4 L 151 4x35 s5s6 Q 73 N.s5s6.02
Van-der-waals TM4 L 151 4x35 s5s6 Q 73 N.s5s6.02
Polar TM5 N 237 5x75 S6 R 85 N.S6.03
Hydrophobic TM3 R 139 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 139 3x50 s5s6 I 79 N.s5s6.08
Polar TM5 S 233 5x71 S6 R 85 N.S6.03
Hydrophobic TM5 S 233 5x71 S6 R 85 N.S6.03
Van-der-waals TM5 S 233 5x71 S6 R 85 N.S6.03
Polar TM5 R 230 5x68 s15s16 Y 254 C.s15s16.03
Aromatic TM5 R 230 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 R 230 5x68 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 R 230 5x68 s15s16 Y 254 C.s15s16.03
Ionic H8 K 343 8x48 s9s10 D 166 N.s9s10.08
Polar H8 K 343 8x48 s9s10 D 166 N.s9s10.08
Hydrophobic H8 K 343 8x48 s9s10 D 166 N.s9s10.08
Van-der-waals H8 K 343 8x48 s9s10 D 166 N.s9s10.08
Hydrophobic TM5 R 230 5x68 S6 F 83 N.S6.01
Van-der-waals TM5 R 230 5x68 S6 F 83 N.S6.01
Hydrophobic TM3 R 139 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 139 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 I 143 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 I 143 3x54 S6 F 83 N.S6.01
Polar TM6 K 279 6x29 S6 R 84 N.S6.02
Hydrophobic TM6 A 283 6x33 s5s6 L 81 N.s5s6.10
Ionic ICL1 R 69 12x48 s20c E 394 C.s20c.13
Polar ICL1 R 69 12x48 s20c E 394 C.s20c.13
Van-der-waals ICL1 R 69 12x48 s20c E 394 C.s20c.13