S-arrestin - 5-HT6 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
5-HT6 66.2
S-arrestin 81.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 16.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Ionic H8 R 333 8x56 s20c E 405 C.s20c.24
Polar H8 R 333 8x56 s20c E 405 C.s20c.24
Hydrophobic H8 R 333 8x56 s20c E 405 C.s20c.24
Van-der-waals H8 R 333 8x56 s20c E 405 C.s20c.24
Hydrophobic ICL3 M 229 - s7s8 P 127 N.s7s8.03
Van-der-waals ICL3 M 229 - s7s8 P 127 N.s7s8.03
Hydrophobic ICL2 L 132 34x51 S9 C 147 N.S9.01
Hydrophobic TM6 H 259 6x26 S6 R 85 N.S6.03
Hydrophobic ICL3 L 255 - S6 F 89 N.S6.07
Van-der-waals ICL3 L 255 - S6 F 89 N.S6.07
Polar TM5 Q 218 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 Q 218 5x68 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 Q 218 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 L 273 6x40 s5s6 I 79 N.s5s6.08
Hydrophobic H8 M 324 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic TM5 I 211 5x61 s5s6 I 79 N.s5s6.08
Hydrophobic TM5 A 215 5x65 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 A 215 5x65 s5s6 L 81 N.s5s6.10
Hydrophobic TM5 V 222 5x72 S6 D 86 N.S6.04
Van-der-waals TM5 V 222 5x72 S6 D 86 N.S6.04
Ionic TM6 R 261 6x28 s9s10 E 164 N.s9s10.06
Polar TM6 R 261 6x28 s9s10 E 164 N.s9s10.06
Van-der-waals TM6 R 261 6x28 s9s10 E 164 N.s9s10.06
Polar ICL2 L 132 34x51 S5 Y 71 N.S5.12
Hydrophobic ICL2 L 132 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 L 132 34x51 S5 Y 71 N.S5.12
Polar TM3 R 124 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 R 124 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 124 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic ICL3 L 255 - S6 D 86 N.S6.04
Van-der-waals ICL3 L 255 - S6 D 86 N.S6.04
Hydrophobic TM3 L 127 3x53 s5s6 I 76 N.s5s6.05
Van-der-waals TM3 L 127 3x53 s5s6 I 76 N.s5s6.05
Ionic ICL2 K 135 34x54 s8s9 D 142 N.s8s9.06
Polar ICL2 K 135 34x54 s8s9 D 142 N.s8s9.06
Hydrophobic ICL2 K 135 34x54 s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 K 135 34x54 s8s9 D 142 N.s8s9.06
Ionic H8 R 329 8x52 s5s6 D 75 N.s5s6.04
Polar H8 R 329 8x52 s5s6 D 75 N.s5s6.04
Hydrophobic H8 R 329 8x52 s5s6 D 75 N.s5s6.04
Van-der-waals H8 R 329 8x52 s5s6 D 75 N.s5s6.04
Hydrophobic TM5 V 222 5x72 S6 R 85 N.S6.03
Van-der-waals TM5 V 222 5x72 S6 R 85 N.S6.03
Ionic TM6 K 258 6x25 S6 D 86 N.S6.04
Polar TM6 K 258 6x25 S6 D 86 N.S6.04
Van-der-waals TM6 K 258 6x25 S6 D 86 N.S6.04
Polar ICL3 Q 232 - S6 S 90 N.S6.08
Hydrophobic ICL3 Q 232 - S6 S 90 N.S6.08
Van-der-waals ICL3 Q 232 - S6 S 90 N.S6.08
Hydrophobic ICL3 R 254 - s9s10 A 163 N.s9s10.05
Polar ICL2 P 131 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 P 131 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 131 34x50 S5 Y 71 N.S5.12
Hydrophobic TM3 I 128 3x54 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 I 128 3x54 s5s6 I 79 N.s5s6.08
Hydrophobic ICL3 D 251 - S6 F 89 N.S6.07
Ionic TM6 K 265 6x32 s5s6 D 77 N.s5s6.06
Polar TM6 K 262 6x29 s5s6 T 82 N.s5s6.11
Van-der-waals TM6 K 262 6x29 s5s6 T 82 N.s5s6.11
Polar ICL2 L 132 34x51 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 L 132 34x51 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 L 132 34x51 s8s9 K 145 N.s8s9.09
Ionic TM6 K 258 6x25 s9s10 E 165 N.s9s10.07
Polar TM6 K 258 6x25 s9s10 E 165 N.s9s10.07
Hydrophobic TM6 K 258 6x25 s9s10 E 165 N.s9s10.07
Van-der-waals TM6 K 258 6x25 s9s10 E 165 N.s9s10.07
Polar ICL3 D 251 - S6 R 91 N.S6.09
Hydrophobic ICL3 D 251 - S6 R 91 N.S6.09
Van-der-waals ICL3 D 251 - S6 R 91 N.S6.09
Polar ICL2 R 133 34x52 S16 Y 259 C.S16.03
Hydrophobic TM6 T 269 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 T 269 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 I 128 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 I 128 3x54 S6 F 83 N.S6.01
Hydrophobic ICL3 M 229 - s7s8 Y 129 N.s7s8.05
Van-der-waals ICL3 M 229 - s7s8 Y 129 N.s7s8.05
Hydrophobic ICL3 M 229 - S6 Y 88 N.S6.06
Van-der-waals ICL3 M 229 - S6 Y 88 N.S6.06
Van-der-waals TM7 F 323 7x56 s5s6 D 77 N.s5s6.06
Hydrophobic ICL2 L 132 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 L 132 34x51 S16 Y 259 C.S16.03
Hydrophobic TM5 Q 221 5x71 s15s16 L 253 C.s15s16.02
Hydrophobic TM6 K 265 6x32 s5s6 G 80 N.s5s6.09
Hydrophobic TM3 R 124 3x50 s5s6 I 79 N.s5s6.08
Polar TM5 Q 221 5x71 S6 R 85 N.S6.03
Hydrophobic TM5 Q 221 5x71 S6 R 85 N.S6.03
Van-der-waals TM5 Q 221 5x71 S6 R 85 N.S6.03
Hydrophobic ICL2 P 131 34x50 S6 F 83 N.S6.01
Polar ICL3 Q 232 - S6 Y 88 N.S6.06
Hydrophobic ICL3 Q 232 - S6 Y 88 N.S6.06
Van-der-waals ICL3 Q 232 - S6 Y 88 N.S6.06
Hydrophobic TM5 L 225 5x75 s7s8 Y 129 N.s7s8.05
Hydrophobic TM5 Y 208 5x58 s5s6 I 79 N.s5s6.08
Ionic ICL2 R 133 34x52 S16 D 257 C.S16.01
Polar ICL2 R 133 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 R 133 34x52 S16 D 257 C.S16.01
Van-der-waals ICL2 R 133 34x52 S16 D 257 C.S16.01
Hydrophobic TM6 A 266 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 A 266 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic TM6 L 270 6x37 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 L 270 6x37 s5s6 I 79 N.s5s6.08
Ionic H8 R 325 8x48 s5s6 D 75 N.s5s6.04
Polar H8 R 325 8x48 s5s6 D 75 N.s5s6.04
Ionic H8 R 333 8x56 s20c D 402 C.s20c.21
Polar H8 R 333 8x56 s20c D 402 C.s20c.21
Van-der-waals H8 R 333 8x56 s20c D 402 C.s20c.21
Hydrophobic ICL2 L 132 34x51 S8 L 136 N.S8.03
Van-der-waals ICL2 L 132 34x51 S8 L 136 N.S8.03
Hydrophobic H8 R 325 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic H8 D 326 8x49 s5s6 D 75 N.s5s6.04
Van-der-waals H8 D 326 8x49 s5s6 D 75 N.s5s6.04
Hydrophobic TM5 L 225 5x75 S6 L 87 N.S6.05
Hydrophobic TM5 I 211 5x61 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 I 211 5x61 s5s6 L 81 N.s5s6.10
Polar TM5 Q 221 5x71 s17s18 T 323 C.s17s18.39
Van-der-waals TM5 Q 221 5x71 s17s18 T 323 C.s17s18.39
Hydrophobic TM5 L 225 5x75 s17s18 V 324 C.s17s18.40
Van-der-waals TM5 L 225 5x75 s17s18 V 324 C.s17s18.40
Hydrophobic ICL2 K 135 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 K 135 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic TM5 L 225 5x75 S6 R 85 N.S6.03
Van-der-waals TM5 L 225 5x75 S6 R 85 N.S6.03
Hydrophobic ICL2 L 132 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 L 132 34x51 S15 V 251 C.S15.14
Ionic TM6 H 259 6x26 S6 D 86 N.S6.04
Polar TM6 H 259 6x26 S6 D 86 N.S6.04
Hydrophobic TM3 L 127 3x53 S6 F 83 N.S6.01
Van-der-waals TM3 L 127 3x53 S6 F 83 N.S6.01
Hydrophobic TM6 H 259 6x26 S6 R 84 N.S6.02
Van-der-waals TM6 H 259 6x26 S6 R 84 N.S6.02