Arrestin-C - 5-HT7 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
5-HT7 65.2
Arrestin-C 81.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar C-term E 423 - S10 Y 160 N.S10.01
Van-der-waals C-term E 423 - S10 Y 160 N.S10.01
Ionic ICL3 R 313 - s9s10 E 152 N.s9s10.07
Polar ICL3 R 313 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL3 R 313 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 R 313 - s9s10 E 152 N.s9s10.07
Polar TM6 K 324 6x32 s5s6 G 68 N.s5s6.09
Hydrophobic TM6 K 324 6x32 s5s6 G 68 N.s5s6.09
Van-der-waals TM6 K 324 6x32 s5s6 G 68 N.s5s6.09
Hydrophobic ICL2 L 188 34x51 S15 V 238 C.S15.14
Van-der-waals ICL2 L 188 34x51 S15 V 238 C.S15.14
Hydrophobic TM3 G 183 3x53 s5s6 L 64 N.s5s6.05
Hydrophobic TM3 I 184 3x54 S6 F 71 N.S6.01
Van-der-waals TM3 I 184 3x54 S6 F 71 N.S6.01
Hydrophobic C-term A 422 - S6 R 72 N.S6.02
Hydrophobic TM3 I 184 3x54 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 I 184 3x54 s5s6 L 69 N.s5s6.10
Polar ICL2 L 188 34x51 S16 D 244 C.S16.01
Hydrophobic ICL2 L 188 34x51 S16 D 244 C.S16.01
Van-der-waals ICL2 L 188 34x51 S16 D 244 C.S16.01
Hydrophobic H8 R 389 8x48 s5s6 E 65 N.s5s6.06
Van-der-waals H8 R 389 8x48 s5s6 E 65 N.s5s6.06
Hydrophobic C-term L 419 - S10 Y 160 N.S10.01
Van-der-waals C-term L 419 - S10 Y 160 N.S10.01
Hydrophobic TM5 H 273 5x72 s15s16 L 240 C.s15s16.02
Van-der-waals TM5 H 273 5x72 s15s16 L 240 C.s15s16.02
Hydrophobic TM6 T 328 6x36 s5s6 V 66 N.s5s6.07
Van-der-waals TM6 T 328 6x36 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 L 188 34x51 S15 T 236 C.S15.12
Hydrophobic C-term H 416 - s9s10 K 157 N.s9s10.12
Van-der-waals C-term H 416 - s9s10 K 157 N.s9s10.12
Hydrophobic ICL2 P 187 34x50 S5 Y 59 N.S5.12
Polar C-term M 415 - S10 R 162 N.S10.03
Van-der-waals C-term M 415 - S10 R 162 N.S10.03
Ionic C-term R 408 - s20c E 383 C.s20c.17
Polar C-term R 408 - s20c E 383 C.s20c.17
Hydrophobic C-term R 408 - s20c E 383 C.s20c.17
Van-der-waals C-term R 408 - s20c E 383 C.s20c.17
Ionic C-term E 423 - S9 K 144 N.S9.08
Hydrophobic H8 N 388 8x47 s5s6 D 63 N.s5s6.04
Polar TM4 G 196 4x39 s8s9 E 131 N.s8s9.05
Hydrophobic TM6 A 325 6x33 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 A 325 6x33 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 L 188 34x51 S8 L 126 N.S8.03
Van-der-waals ICL2 L 188 34x51 S8 L 126 N.S8.03
Polar C-term A 418 - S6 R 72 N.S6.02
Van-der-waals C-term A 418 - S6 R 72 N.S6.02
Hydrophobic C-term L 421 - s5s6 E 65 N.s5s6.06
Van-der-waals C-term L 421 - s5s6 E 65 N.s5s6.06
Ionic ICL1 K 111 12x49 s5s6 D 62 N.s5s6.03
Polar ICL1 K 111 12x49 s5s6 D 62 N.s5s6.03
Van-der-waals ICL1 K 111 12x49 s5s6 D 62 N.s5s6.03
Hydrophobic TM3 I 184 3x54 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 I 184 3x54 s5s6 I 67 N.s5s6.08
Hydrophobic C-term E 423 - s9s10 T 154 N.s9s10.09
Van-der-waals C-term E 423 - s9s10 T 154 N.s9s10.09
Polar ICL2 Q 194 34x57 s17s18 R 282 C.s17s18.11
Polar TM5 H 273 5x72 s15s16 Y 241 C.s15s16.03
Aromatic TM5 H 273 5x72 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 H 273 5x72 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 H 273 5x72 s15s16 Y 241 C.s15s16.03
Polar C-term A 412 - s9s10 K 157 N.s9s10.12
Van-der-waals C-term A 412 - s9s10 K 157 N.s9s10.12
Polar TM2 S 116 2x39 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 S 116 2x39 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 S 116 2x39 s5s6 D 63 N.s5s6.04
Polar TM2 S 116 2x39 s5s6 R 61 N.s5s6.02
Van-der-waals TM2 S 116 2x39 s5s6 R 61 N.s5s6.02
Polar ICL2 T 189 34x52 S16 D 244 C.S16.01
Hydrophobic ICL2 T 189 34x52 S16 D 244 C.S16.01
Van-der-waals ICL2 T 189 34x52 S16 D 244 C.S16.01
Hydrophobic TM3 R 180 3x50 s5s6 L 64 N.s5s6.05
Hydrophobic C-term M 415 - s9s10 K 157 N.s9s10.12
Hydrophobic TM6 I 332 6x40 s5s6 V 66 N.s5s6.07
Hydrophobic ICL3 F 278 - s7s8 N 119 N.s7s8.05
Hydrophobic ICL2 T 189 34x52 S16 K 245 C.S16.02
Hydrophobic H8 N 388 8x47 s5s6 V 66 N.s5s6.07
Van-der-waals H8 N 388 8x47 s5s6 V 66 N.s5s6.07
Hydrophobic C-term L 421 - s5s6 T 70 N.s5s6.11
Hydrophobic C-term L 419 - S10 R 162 N.S10.03
Van-der-waals C-term L 419 - S10 R 162 N.S10.03
Polar TM3 T 185 3x55 s15s16 S 242 C.s15s16.04
Hydrophobic TM3 T 185 3x55 s15s16 S 242 C.s15s16.04
Van-der-waals TM3 T 185 3x55 s15s16 S 242 C.s15s16.04
Ionic TM3 D 179 3x49 s5s6 R 61 N.s5s6.02
Hydrophobic C-term A 418 - s8s9 K 135 N.s8s9.09
Hydrophobic ICL2 T 189 34x52 S16 Y 246 C.S16.03
Van-der-waals ICL2 T 189 34x52 S16 Y 246 C.S16.03
Hydrophobic ICL3 F 278 - s7s8 V 117 N.s7s8.03
Van-der-waals ICL3 F 278 - s7s8 V 117 N.s7s8.03
Hydrophobic TM3 R 180 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 180 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 R 186 3x56 S16 D 244 C.S16.01
Van-der-waals TM3 R 186 3x56 S16 D 244 C.S16.01
Hydrophobic TM5 A 266 5x65 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 A 266 5x65 s5s6 L 69 N.s5s6.10
Polar TM2 Q 114 2x37 s8s9 A 133 N.s8s9.07
Hydrophobic TM2 Q 114 2x37 s8s9 A 133 N.s8s9.07
Hydrophobic ICL2 P 187 34x50 S15 V 238 C.S15.14
Polar ICL3 R 280 - S6 Y 76 N.S6.06
Van-der-waals ICL3 R 280 - S6 Y 76 N.S6.06
Polar ICL2 V 192 34x55 s17s18 R 282 C.s17s18.11
Hydrophobic ICL2 V 192 34x55 s17s18 R 282 C.s17s18.11
Van-der-waals ICL2 V 192 34x55 s17s18 R 282 C.s17s18.11
Hydrophobic C-term P 425 - s9s10 T 154 N.s9s10.09
Polar TM6 K 324 6x32 s5s6 E 65 N.s5s6.06
Hydrophobic C-term L 419 - s9s10 K 157 N.s9s10.12
Van-der-waals C-term L 419 - s9s10 K 157 N.s9s10.12
Hydrophobic TM6 A 325 6x33 s5s6 G 68 N.s5s6.09
Hydrophobic TM3 R 180 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 180 3x50 s5s6 V 66 N.s5s6.07
Polar ICL2 Q 194 34x57 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 Q 194 34x57 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 Q 194 34x57 s5s6 R 61 N.s5s6.02
Hydrophobic TM6 T 328 6x36 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 F 275 5x74 s17s18 L 311 C.s17s18.40
Van-der-waals TM5 F 275 5x74 s17s18 L 311 C.s17s18.40
Polar TM6 R 321 6x29 s5s6 T 70 N.s5s6.11
Polar ICL2 P 191 34x54 s17s18 R 282 C.s17s18.11
Hydrophobic ICL2 P 191 34x54 s17s18 R 282 C.s17s18.11
Van-der-waals ICL2 P 191 34x54 s17s18 R 282 C.s17s18.11
Hydrophobic TM5 I 262 5x61 s5s6 I 67 N.s5s6.08
Van-der-waals TM5 I 262 5x61 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 I 262 5x61 s5s6 L 69 N.s5s6.10
Polar TM6 R 321 6x29 S6 R 72 N.S6.02
Van-der-waals TM6 R 321 6x29 S6 R 72 N.S6.02
Hydrophobic TM6 L 329 6x37 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 L 329 6x37 s5s6 I 67 N.s5s6.08
Polar ICL3 K 314 - S6 L 75 N.S6.05
Van-der-waals ICL3 K 314 - S6 L 75 N.S6.05
Polar TM5 H 273 5x72 S6 K 73 N.S6.03
Hydrophobic TM5 H 273 5x72 S6 K 73 N.S6.03
Van-der-waals TM5 H 273 5x72 S6 K 73 N.S6.03
Hydrophobic ICL2 L 188 34x51 S16 Y 246 C.S16.03
Van-der-waals ICL2 L 188 34x51 S16 Y 246 C.S16.03
Hydrophobic ICL2 L 188 34x51 S9 C 137 N.S9.01
Van-der-waals ICL2 L 188 34x51 S9 C 137 N.S9.01
Van-der-waals C-term R 408 - s20c G 384 C.s20c.18
Polar ICL2 P 187 34x50 S16 D 244 C.S16.01
Hydrophobic ICL2 P 187 34x50 S16 D 244 C.S16.01
Van-der-waals ICL2 P 187 34x50 S16 D 244 C.S16.01
Polar C-term R 408 - s20c V 380 C.s20c.13
Hydrophobic C-term R 408 - s20c V 380 C.s20c.13
Van-der-waals C-term R 408 - s20c V 380 C.s20c.13
Polar ICL3 R 280 - S6 Q 78 N.S6.08
Hydrophobic ICL3 R 280 - S6 Q 78 N.S6.08
Van-der-waals ICL3 R 280 - S6 Q 78 N.S6.08
Polar TM7 F 387 7x56 s5s6 V 66 N.s5s6.07
Hydrophobic TM7 F 387 7x56 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 F 387 7x56 s5s6 V 66 N.s5s6.07
Polar TM5 S 269 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 S 269 5x68 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 S 269 5x68 s15s16 Y 241 C.s15s16.03
Ionic TM6 R 321 6x29 S6 D 74 N.S6.04
Polar TM6 R 321 6x29 S6 D 74 N.S6.04
Van-der-waals TM6 R 321 6x29 S6 D 74 N.S6.04
Hydrophobic ICL2 P 187 34x50 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 P 187 34x50 s15s16 S 242 C.s15s16.04
Hydrophobic TM5 F 275 5x74 S6 L 75 N.S6.05
Van-der-waals TM5 F 275 5x74 S6 L 75 N.S6.05
Hydrophobic TM5 F 275 5x74 S6 K 73 N.S6.03
Van-der-waals TM5 F 275 5x74 S6 K 73 N.S6.03
Ionic TM5 K 272 5x71 s17s18 E 310 C.s17s18.39
Polar TM5 K 272 5x71 s17s18 E 310 C.s17s18.39
Hydrophobic TM5 K 272 5x71 s17s18 E 310 C.s17s18.39
Van-der-waals TM5 K 272 5x71 s17s18 E 310 C.s17s18.39