Beta-arrestin-2 - A1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
A1 82.9
Beta-arrestin-2 79.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM2 D 42 2x37 s5s6 L 69 N.s5s6.05
Polar TM6 K 228 6x29 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 K 228 6x29 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 K 228 6x29 s5s6 L 72 N.s5s6.08
Polar ICL2 L 113 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 L 113 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 L 113 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 R 108 3x53 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 R 108 3x53 s5s6 L 74 N.s5s6.10
Polar ICL2 L 113 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 113 34x51 S16 Y 250 C.S16.03
Hydrophobic TM6 P 222 6x23 S6 K 78 N.S6.03
Van-der-waals TM6 P 222 6x23 S6 K 78 N.S6.03
Hydrophobic TM6 Y 225 6x26 s5s6 S 75 N.s5s6.11
Hydrophobic TM6 K 228 6x29 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 L 113 34x51 s15s16 T 247 C.s15s16.05
Van-der-waals ICL2 L 113 34x51 s15s16 T 247 C.s15s16.05
Polar ICL3 S 219 - S6 D 79 N.S6.04
Hydrophobic ICL3 S 219 - S6 D 79 N.S6.04
Van-der-waals ICL3 S 219 - S6 D 79 N.S6.04
Hydrophobic TM6 D 221 6x22 S6 K 78 N.S6.03
Van-der-waals TM6 D 221 6x22 S6 K 78 N.S6.03
Polar ICL2 P 112 34x50 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 P 112 34x50 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 P 112 34x50 s15s16 S 246 C.s15s16.04
Hydrophobic TM6 E 229 6x30 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 E 229 6x30 s5s6 L 74 N.s5s6.10
Polar TM3 I 111 3x56 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 I 111 3x56 s15s16 S 246 C.s15s16.04
Van-der-waals TM3 I 111 3x56 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 R 114 34x52 S16 A 248 C.S16.01
Van-der-waals ICL2 R 114 34x52 S16 A 248 C.S16.01
Hydrophobic ICL2 K 116 34x54 s8s9 K 139 N.s8s9.09
Van-der-waals ICL2 K 116 34x54 s8s9 K 139 N.s8s9.09
Hydrophobic ICL2 L 113 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 113 34x51 S15 I 242 C.S15.14
Polar ICL2 L 113 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 L 113 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 L 113 34x51 S5 Y 64 N.S5.12
Polar ICL2 K 116 34x54 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 K 116 34x54 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 K 116 34x54 s8s9 T 137 N.s8s9.07
Polar H8 K 294 8x49 s5s6 L 72 N.s5s6.08
Hydrophobic H8 K 294 8x49 s5s6 L 72 N.s5s6.08
Van-der-waals H8 K 294 8x49 s5s6 L 72 N.s5s6.08
Polar ICL3 S 218 - S6 I 82 N.S6.07
Hydrophobic TM6 D 221 6x22 S6 D 79 N.S6.04
Van-der-waals TM6 D 221 6x22 S6 D 79 N.S6.04
Van-der-waals ICL2 L 113 34x51 s15s16 L 244 C.s15s16.02
Hydrophobic ICL2 P 112 34x50 s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 P 112 34x50 s15s16 F 245 C.s15s16.03
Polar TM6 K 228 6x29 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 K 228 6x29 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 K 228 6x29 s5s6 G 73 N.s5s6.09
Hydrophobic TM4 T 120 4x38 s8s9 T 137 N.s8s9.07
Aromatic TM6 Y 225 6x26 S6 F 76 N.S6.01
Hydrophobic TM6 Y 225 6x26 S6 F 76 N.S6.01
Van-der-waals TM6 Y 225 6x26 S6 F 76 N.S6.01
Aromatic TM6 Y 225 6x26 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 Y 225 6x26 s15s16 F 245 C.s15s16.03
Van-der-waals TM6 Y 225 6x26 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 I 232 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 K 116 34x54 s5s6 L 69 N.s5s6.05
Van-der-waals ICL2 K 116 34x54 s5s6 L 69 N.s5s6.05
Hydrophobic TM2 D 42 2x37 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 D 221 6x22 S6 F 76 N.S6.01
Polar ICL2 P 112 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 112 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 112 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 M 117 34x55 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 M 117 34x55 s8s9 D 136 N.s8s9.06
Hydrophobic ICL3 S 219 - S6 L 80 N.S6.05
Hydrophobic TM6 Y 225 6x26 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 Y 225 6x26 s5s6 L 74 N.s5s6.10
Hydrophobic ICL1 A 39 12x49 s5s6 V 71 N.s5s6.07
Van-der-waals ICL1 A 39 12x49 s5s6 V 71 N.s5s6.07
Polar ICL2 R 114 34x52 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 M 117 34x55 S16 Y 250 C.S16.03
Van-der-waals ICL2 M 117 34x55 S16 Y 250 C.S16.03
Polar ICL2 M 117 34x55 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 M 117 34x55 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 L 113 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 L 113 34x51 S16 A 248 C.S16.01
Hydrophobic ICL2 K 116 34x54 s8s9 G 138 N.s8s9.08
Van-der-waals ICL2 K 116 34x54 s8s9 G 138 N.s8s9.08
Hydrophobic TM2 F 45 2x40 s5s6 L 72 N.s5s6.08
Van-der-waals TM2 F 45 2x40 s5s6 L 72 N.s5s6.08
Polar TM6 Y 226 6x27 s15s16 F 245 C.s15s16.03
Aromatic TM6 Y 226 6x27 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 Y 226 6x27 s15s16 F 245 C.s15s16.03
Van-der-waals TM6 Y 226 6x27 s15s16 F 245 C.s15s16.03
Hydrophobic H8 K 294 8x49 s5s6 V 71 N.s5s6.07
Van-der-waals H8 K 294 8x49 s5s6 V 71 N.s5s6.07
Ionic TM6 D 221 6x22 S6 R 77 N.S6.02
Polar TM6 D 221 6x22 S6 R 77 N.S6.02
Hydrophobic TM6 D 221 6x22 S6 R 77 N.S6.02
Van-der-waals TM6 D 221 6x22 S6 R 77 N.S6.02
Hydrophobic ICL1 A 39 12x49 s5s6 L 72 N.s5s6.08
Van-der-waals ICL1 A 39 12x49 s5s6 L 72 N.s5s6.08
Hydrophobic ICL1 L 40 12x50 s5s6 L 72 N.s5s6.08
Polar TM6 P 222 6x23 S6 R 77 N.S6.02
Hydrophobic TM4 P 121 4x39 s8s9 T 137 N.s8s9.07
Hydrophobic TM6 P 222 6x23 S6 F 76 N.S6.01
Van-der-waals TM6 P 222 6x23 S6 F 76 N.S6.01
Hydrophobic TM3 K 110 3x55 s15s16 S 246 C.s15s16.04
Ionic TM5 K 213 5x71 s17s18 E 314 C.s17s18.39
Polar TM5 K 213 5x71 s17s18 E 314 C.s17s18.39
Hydrophobic TM5 K 213 5x71 s17s18 E 314 C.s17s18.39
Van-der-waals TM5 K 213 5x71 s17s18 E 314 C.s17s18.39