Beta-arrestin-1 - A2A receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
A2A 69.9
Beta-arrestin-1 81.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 Q 207 5x68 S6 F 75 N.S6.01
Van-der-waals TM5 Q 207 5x68 S6 F 75 N.S6.01
Hydrophobic ICL2 L 110 34x51 S9 C 140 N.S9.01
Hydrophobic TM5 M 211 5x72 s15s16 F 244 C.s15s16.03
Polar H8 R 293 8x48 s5s6 D 69 N.s5s6.06
Van-der-waals H8 R 293 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic TM6 A 231 6x33 s5s6 L 73 N.s5s6.10
Ionic TM6 R 220 6x22 S6 D 78 N.S6.04
Polar TM6 R 220 6x22 S6 D 78 N.S6.04
Van-der-waals TM6 R 220 6x22 S6 D 78 N.S6.04
Polar TM5 S 213 5x74 S6 D 78 N.S6.04
Hydrophobic TM5 S 213 5x74 S6 D 78 N.S6.04
Van-der-waals TM5 S 213 5x74 S6 D 78 N.S6.04
Hydrophobic ICL2 P 109 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 109 34x50 S5 Y 63 N.S5.12
Hydrophobic TM5 S 213 5x74 S6 K 77 N.S6.03
Hydrophobic TM6 A 231 6x33 s5s6 L 71 N.s5s6.08
Polar ICL2 L 110 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 L 110 34x51 S5 Y 63 N.S5.12
Van-der-waals ICL2 L 110 34x51 S5 Y 63 N.S5.12
Hydrophobic TM6 E 219 6x21 s9s10 E 155 N.s9s10.07
Ionic TM3 R 102 3x50 s5s6 D 67 N.s5s6.04
Polar TM3 R 102 3x50 s5s6 D 67 N.s5s6.04
Van-der-waals TM3 R 102 3x50 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 L 110 34x51 S8 L 129 N.S8.03
Ionic C-term E 396 - S15 R 236 C.S15.09
Polar C-term E 396 - S15 R 236 C.S15.09
Van-der-waals C-term E 396 - S15 R 236 C.S15.09
Hydrophobic ICL2 L 110 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 L 110 34x51 S16 A 247 C.S16.01
Polar ICL2 N 113 34x54 s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 N 113 34x54 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 N 113 34x54 s8s9 D 135 N.s8s9.06
Hydrophobic TM5 M 211 5x72 S6 K 77 N.S6.03
Polar C-term C 394 - s17s18 R 285 C.s17s18.11
Van-der-waals C-term C 394 - s17s18 R 285 C.s17s18.11
Polar TM6 H 230 6x32 s5s6 L 71 N.s5s6.08
Polar C-term C 394 - S16 C 251 C.S16.05
Hydrophobic C-term C 394 - S16 C 251 C.S16.05
Van-der-waals C-term C 394 - S16 C 251 C.S16.05
Polar TM2 N 39 2x37 s8s9 T 136 N.s8s9.07
Polar H8 Q 297 8x52 s20c E 407 C.s20c.17
Hydrophobic TM5 Q 210 5x71 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 Q 210 5x71 s15s16 F 244 C.s15s16.03
Polar C-term G 392 - S16 K 250 C.S16.04
Van-der-waals C-term G 392 - S16 K 250 C.S16.04
Polar TM2 T 41 2x39 s5s6 D 67 N.s5s6.04
Hydrophobic TM5 M 211 5x72 S6 F 75 N.S6.01
Van-der-waals TM5 M 211 5x72 S6 F 75 N.S6.01
Polar TM3 R 107 3x55 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 R 107 3x55 s15s16 N 245 C.s15s16.04
Polar C-term C 394 - S16 K 250 C.S16.04
Hydrophobic C-term C 394 - S16 K 250 C.S16.04
Van-der-waals C-term C 394 - S16 K 250 C.S16.04
Hydrophobic ICL2 Y 112 34x53 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 Y 112 34x53 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 A 105 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic TM6 L 235 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 235 6x37 s5s6 L 71 N.s5s6.08
Ionic H8 R 293 8x48 s20c E 407 C.s20c.17
Polar H8 R 293 8x48 s20c E 407 C.s20c.17
Hydrophobic H8 R 293 8x48 s20c E 407 C.s20c.17
Van-der-waals H8 R 293 8x48 s20c E 407 C.s20c.17
Hydrophobic TM3 I 106 3x54 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 L 208 5x69 s5s6 L 73 N.s5s6.10
Hydrophobic TM5 M 211 5x72 S6 R 76 N.S6.02
Van-der-waals TM5 M 211 5x72 S6 R 76 N.S6.02
Hydrophobic ICL2 L 110 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 L 110 34x51 S15 I 241 C.S15.14
Van-der-waals TM5 Q 210 5x71 S6 K 77 N.S6.03
Hydrophobic TM5 Q 207 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 Q 207 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic TM3 R 102 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 102 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM5 M 211 5x72 s5s6 T 74 N.s5s6.11
Polar ICL2 N 113 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 N 113 34x54 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 N 113 34x54 s5s6 R 65 N.s5s6.02
Polar TM7 R 291 7x56 s5s6 V 70 N.s5s6.07
Hydrophobic TM7 R 291 7x56 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 R 291 7x56 s5s6 V 70 N.s5s6.07
Hydrophobic H8 I 292 8x47 s5s6 D 69 N.s5s6.06
Van-der-waals H8 I 292 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic ICL2 L 110 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic TM5 I 200 5x61 s5s6 L 71 N.s5s6.08
Polar C-term G 392 - S16 Q 248 C.S16.02
Van-der-waals C-term G 392 - S16 Q 248 C.S16.02
Hydrophobic C-term K 391 - S16 K 250 C.S16.04
Polar ICL2 L 110 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 L 110 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 L 110 34x51 S16 Y 249 C.S16.03
Hydrophobic TM6 K 227 6x29 s5s6 L 73 N.s5s6.10
Hydrophobic TM5 A 204 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 A 204 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic TM5 A 204 5x65 s5s6 L 71 N.s5s6.08
Van-der-waals TM5 A 204 5x65 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 I 106 3x54 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 I 106 3x54 s5s6 L 68 N.s5s6.05