Beta-arrestin-1 - A2B receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
A2B 81.7
Beta-arrestin-1 79.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 Q 212 5x68 S6 F 75 N.S6.01
Van-der-waals TM5 Q 212 5x68 S6 F 75 N.S6.01
Hydrophobic H8 R 295 8x48 s9s10 K 160 N.s9s10.12
Polar TM5 T 216 5x72 S6 K 77 N.S6.03
Hydrophobic TM5 T 216 5x72 S6 K 77 N.S6.03
Van-der-waals TM5 T 216 5x72 S6 K 77 N.S6.03
Polar TM2 T 42 2x39 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 L 111 34x51 S8 L 129 N.S8.03
Van-der-waals ICL2 L 111 34x51 S8 L 129 N.S8.03
Polar TM5 Q 212 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 Q 212 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 Q 212 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 K 114 34x54 s8s9 T 136 N.s8s9.07
Polar ICL2 P 110 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 P 110 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 110 34x50 S5 Y 63 N.S5.12
Hydrophobic TM3 R 103 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 103 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 I 107 3x54 S6 F 75 N.S6.01
Van-der-waals TM3 I 107 3x54 S6 F 75 N.S6.01
Polar ICL2 K 114 34x54 s8s9 G 137 N.s8s9.08
Hydrophobic ICL2 K 114 34x54 s8s9 G 137 N.s8s9.08
Van-der-waals ICL2 K 114 34x54 s8s9 G 137 N.s8s9.08
Ionic TM3 R 103 3x50 s5s6 D 67 N.s5s6.04
Polar TM3 R 103 3x50 s5s6 D 67 N.s5s6.04
Van-der-waals TM3 R 103 3x50 s5s6 D 67 N.s5s6.04
Van-der-waals TM4 T 118 4x38 s8s9 E 134 N.s8s9.05
Ionic H8 R 295 8x48 s20c E 407 C.s20c.17
Hydrophobic TM3 I 107 3x54 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 I 107 3x54 s5s6 L 68 N.s5s6.05
Polar ICL2 K 114 34x54 s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 K 114 34x54 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 K 114 34x54 s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 L 111 34x51 S9 C 140 N.S9.01
Van-der-waals ICL2 K 114 34x54 s8s9 P 131 N.s8s9.02
Hydrophobic TM5 I 205 5x61 s5s6 L 71 N.s5s6.08
Van-der-waals TM5 I 205 5x61 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 I 239 6x40 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 I 239 6x40 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 L 111 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 L 111 34x51 S15 I 241 C.S15.14
Hydrophobic TM5 L 213 5x69 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 S 235 6x36 s5s6 L 71 N.s5s6.08
Polar TM3 C 108 3x55 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 C 108 3x55 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 C 108 3x55 s15s16 N 245 C.s15s16.04
Hydrophobic TM6 A 232 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 232 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic ICL3 M 219 - S6 F 80 N.S6.06
Hydrophobic ICL2 Y 113 34x53 s5s6 R 65 N.s5s6.02
Polar ICL2 L 111 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 L 111 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 L 111 34x51 S16 Y 249 C.S16.03
Hydrophobic TM6 L 236 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 236 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 R 103 3x50 s5s6 L 68 N.s5s6.05
Hydrophobic ICL2 P 110 34x50 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 P 110 34x50 s15s16 N 245 C.s15s16.04
Hydrophobic TM5 A 209 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 A 209 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 L 111 34x51 S5 Y 63 N.S5.12
Van-der-waals ICL2 L 111 34x51 S5 Y 63 N.S5.12
Hydrophobic TM7 R 293 7x56 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 R 293 7x56 s5s6 V 70 N.s5s6.07
Polar TM5 T 216 5x72 S6 R 76 N.S6.02
Hydrophobic TM5 T 216 5x72 S6 R 76 N.S6.02
Van-der-waals TM5 T 216 5x72 S6 R 76 N.S6.02
Ionic H8 R 295 8x48 s20c E 405 C.s20c.15
Hydrophobic ICL2 L 111 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 L 111 34x51 S16 A 247 C.S16.01
Ionic TM5 R 215 5x71 s17s18 E 313 C.s17s18.39
Polar TM5 R 215 5x71 s17s18 E 313 C.s17s18.39
Hydrophobic TM5 R 215 5x71 s17s18 E 313 C.s17s18.39
Van-der-waals TM5 R 215 5x71 s17s18 E 313 C.s17s18.39
Polar TM5 R 215 5x71 S6 K 77 N.S6.03
Hydrophobic TM5 R 215 5x71 S6 K 77 N.S6.03
Van-der-waals TM5 R 215 5x71 S6 K 77 N.S6.03
Hydrophobic ICL2 K 114 34x54 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 K 114 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 A 106 3x53 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 A 106 3x53 s5s6 L 68 N.s5s6.05