Beta-arrestin-1 - ACKR2 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
ACKR2 72.3
Beta-arrestin-1 80.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 19.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 I 233 5x61 s5s6 L 71 N.s5s6.08
Ionic TM3 E 145 3x53 s8s9 K 138 N.s8s9.09
Polar TM3 E 145 3x53 s8s9 K 138 N.s8s9.09
Hydrophobic TM3 E 145 3x53 s8s9 K 138 N.s8s9.09
Van-der-waals TM3 E 145 3x53 s8s9 K 138 N.s8s9.09
Polar ICL2 Q 150 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 Q 150 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 Q 150 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic TM5 L 237 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 237 5x65 s5s6 L 73 N.s5s6.10
Polar H8 S 316 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic H8 S 316 8x47 s5s6 D 69 N.s5s6.06
Van-der-waals H8 S 316 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic TM5 L 237 5x65 S6 F 75 N.S6.01
Polar ICL2 Q 150 34x51 s8s9 G 137 N.s8s9.08
Hydrophobic ICL2 Q 150 34x51 s8s9 G 137 N.s8s9.08
Van-der-waals ICL2 Q 150 34x51 s8s9 G 137 N.s8s9.08
Polar ICL2 Q 150 34x51 S5 Y 63 N.S5.12
Ionic H8 R 318 8x49 s5s6 D 67 N.s5s6.04
Polar H8 R 318 8x49 s5s6 D 67 N.s5s6.04
Hydrophobic H8 R 318 8x49 s5s6 D 67 N.s5s6.04
Van-der-waals H8 R 318 8x49 s5s6 D 67 N.s5s6.04
Polar H8 R 318 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic H8 R 318 8x49 s5s6 D 69 N.s5s6.06
Van-der-waals H8 R 318 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic TM5 L 240 5x68 S6 F 75 N.S6.01
Polar ICL2 Q 150 34x51 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 Q 150 34x51 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 Q 150 34x51 s8s9 T 136 N.s8s9.07
Hydrophobic TM6 Q 245 6x30 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 E 145 3x53 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 E 145 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic TM5 Y 230 5x58 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 K 142 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 K 142 3x50 s5s6 V 70 N.s5s6.07
Polar TM7 S 315 7x56 s5s6 G 72 N.s5s6.09
Van-der-waals TM7 S 315 7x56 s5s6 G 72 N.s5s6.09
Hydrophobic TM6 L 255 6x40 s5s6 L 71 N.s5s6.08
Polar TM6 A 243 6x28 S6 R 76 N.S6.02
Ionic ICL1 R 78 12x51 s20c D 402 C.s20c.12
Hydrophobic TM3 I 146 3x54 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 I 146 3x54 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 I 251 6x36 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 I 251 6x36 s5s6 L 71 N.s5s6.08
Ionic TM2 R 79 2x37 s20c E 405 C.s20c.15
Hydrophobic TM3 E 145 3x53 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 E 145 3x53 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 I 146 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 R 154 34x55 s8s9 T 136 N.s8s9.07
Hydrophobic TM3 I 146 3x54 S6 F 75 N.S6.01
Van-der-waals TM3 I 146 3x54 S6 F 75 N.S6.01
Polar H8 H 317 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic H8 H 317 8x48 s5s6 D 69 N.s5s6.06
Van-der-waals H8 H 317 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic TM6 A 252 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 Q 150 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 Q 150 34x51 S16 A 247 C.S16.01
Polar ICL2 A 149 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 A 149 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 A 149 34x50 S5 Y 63 N.S5.12
Ionic H8 R 318 8x49 s20c E 405 C.s20c.15
Polar H8 R 318 8x49 s20c E 405 C.s20c.15
Van-der-waals H8 R 318 8x49 s20c E 405 C.s20c.15
Van-der-waals ICL2 A 149 34x50 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 I 146 3x54 s5s6 L 71 N.s5s6.08
Polar ICL2 A 149 34x50 s8s9 K 138 N.s8s9.09
Hydrophobic ICL2 A 149 34x50 s8s9 K 138 N.s8s9.09
Hydrophobic ICL2 H 153 34x54 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 H 153 34x54 s8s9 D 135 N.s8s9.06
Hydrophobic TM3 K 142 3x50 s5s6 L 71 N.s5s6.08
Polar ICL2 Q 150 34x51 s15s16 T 246 C.s15s16.05
Hydrophobic ICL2 Q 150 34x51 s15s16 T 246 C.s15s16.05
Van-der-waals ICL2 Q 150 34x51 s15s16 T 246 C.s15s16.05
Hydrophobic TM5 L 240 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 L 240 5x68 s15s16 F 244 C.s15s16.03
Polar ICL2 H 153 34x54 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 H 153 34x54 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 H 153 34x54 s8s9 T 136 N.s8s9.07
Hydrophobic ICL3 P 242 - s5s6 L 73 N.s5s6.10
Polar ICL2 P 151 34x52 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 P 151 34x52 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 P 151 34x52 s8s9 T 136 N.s8s9.07
Polar TM3 V 147 3x55 s15s16 N 245 C.s15s16.04
Polar C-term S 343 - s20c K 403 C.s20c.13
Ionic ICL2 R 154 34x55 s8s9 E 134 N.s8s9.05
Polar ICL2 R 154 34x55 s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 R 154 34x55 s8s9 E 134 N.s8s9.05
Van-der-waals ICL2 R 154 34x55 s8s9 E 134 N.s8s9.05
Polar H8 Y 322 8x53 s20c E 405 C.s20c.15
Ionic TM2 R 79 2x37 s5s6 D 67 N.s5s6.04
Polar TM2 R 79 2x37 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 R 79 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic TM6 G 244 6x29 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 A 248 6x33 s5s6 L 71 N.s5s6.08
Polar TM7 S 315 7x56 s5s6 L 71 N.s5s6.08
Van-der-waals TM7 S 315 7x56 s5s6 L 71 N.s5s6.08
Hydrophobic H8 H 317 8x48 s5s6 G 72 N.s5s6.09
Polar ICL2 H 153 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 H 153 34x54 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 H 153 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic TM6 A 248 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 248 6x33 s5s6 L 73 N.s5s6.10