Arrestin-C - ACKR2 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ACKR2 70.9
Arrestin-C 79.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.4
PAE mean: 22.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 240 5x68 s15s16 L 240 C.s15s16.02
Van-der-waals ICL3 P 242 - s15s16 Y 241 C.s15s16.03
Polar TM3 E 145 3x53 s8s9 K 135 N.s8s9.09
Hydrophobic TM3 E 145 3x53 s8s9 K 135 N.s8s9.09
Van-der-waals TM3 E 145 3x53 s8s9 K 135 N.s8s9.09
Hydrophobic ICL2 Y 152 34x53 s5s6 L 64 N.s5s6.05
Van-der-waals ICL2 Y 152 34x53 s5s6 L 64 N.s5s6.05
Hydrophobic TM3 E 145 3x53 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 E 145 3x53 s5s6 L 64 N.s5s6.05
Ionic H8 R 318 8x49 s5s6 E 65 N.s5s6.06
Polar H8 R 318 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic H8 R 318 8x49 s5s6 E 65 N.s5s6.06
Van-der-waals H8 R 318 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic TM5 L 237 5x65 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 L 237 5x65 s5s6 L 69 N.s5s6.10
Hydrophobic TM2 V 81 2x39 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 V 81 2x39 s5s6 V 66 N.s5s6.07
Hydrophobic TM5 L 237 5x65 S6 F 71 N.S6.01
Polar H8 S 316 8x47 s5s6 E 65 N.s5s6.06
Van-der-waals H8 S 316 8x47 s5s6 E 65 N.s5s6.06
Hydrophobic TM5 Y 230 5x58 s5s6 I 67 N.s5s6.08
Polar TM3 K 142 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 K 142 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 K 142 3x50 s5s6 V 66 N.s5s6.07
Polar ICL2 A 149 34x50 s8s9 K 135 N.s8s9.09
Hydrophobic ICL2 A 149 34x50 s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 A 149 34x50 s8s9 K 135 N.s8s9.09
Polar TM7 S 315 7x56 s5s6 V 66 N.s5s6.07
Hydrophobic TM7 S 315 7x56 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 S 315 7x56 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 P 151 34x52 s8s9 K 135 N.s8s9.09
Polar TM5 L 240 5x68 S6 K 73 N.S6.03
Hydrophobic TM6 I 251 6x36 s5s6 I 67 N.s5s6.08
Hydrophobic H8 H 317 8x48 s5s6 G 68 N.s5s6.09
Polar ICL2 P 151 34x52 s8s9 A 133 N.s8s9.07
Hydrophobic ICL2 P 151 34x52 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 P 151 34x52 s8s9 A 133 N.s8s9.07
Hydrophobic TM5 L 240 5x68 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 L 240 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 L 155 34x56 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 L 155 34x56 s5s6 R 61 N.s5s6.02
Polar ICL2 H 153 34x54 s5s6 R 61 N.s5s6.02
Aromatic ICL2 H 153 34x54 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 H 153 34x54 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 H 153 34x54 s5s6 R 61 N.s5s6.02
Polar ICL2 Y 152 34x53 s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 Y 152 34x53 s5s6 D 63 N.s5s6.04
Van-der-waals ICL2 Y 152 34x53 s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 Q 150 34x51 s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 Q 150 34x51 s8s9 K 135 N.s8s9.09
Ionic ICL1 R 78 12x51 s20c E 383 C.s20c.17
Polar ICL1 R 78 12x51 s20c E 383 C.s20c.17
Hydrophobic ICL1 R 78 12x51 s20c E 383 C.s20c.17
Van-der-waals ICL1 R 78 12x51 s20c E 383 C.s20c.17
Polar ICL2 Y 152 34x53 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 Y 152 34x53 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 Y 152 34x53 s5s6 R 61 N.s5s6.02
Polar ICL2 R 154 34x55 s8s9 P 130 N.s8s9.04
Van-der-waals ICL2 R 154 34x55 s8s9 P 130 N.s8s9.04
Polar H8 R 318 8x49 s5s6 D 62 N.s5s6.03
Hydrophobic H8 R 318 8x49 s5s6 D 62 N.s5s6.03
Van-der-waals H8 R 318 8x49 s5s6 D 62 N.s5s6.03
Ionic TM2 R 79 2x37 s5s6 D 63 N.s5s6.04
Polar TM2 R 79 2x37 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 R 79 2x37 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 R 79 2x37 s5s6 D 63 N.s5s6.04
Hydrophobic TM3 K 142 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 K 142 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals ICL2 P 151 34x52 s8s9 D 132 N.s8s9.06
Polar ICL2 P 151 34x52 s8s9 G 134 N.s8s9.08
Hydrophobic ICL2 P 151 34x52 s8s9 G 134 N.s8s9.08
Van-der-waals ICL2 P 151 34x52 s8s9 G 134 N.s8s9.08
Hydrophobic TM3 I 146 3x54 S6 F 71 N.S6.01
Van-der-waals TM3 I 146 3x54 S6 F 71 N.S6.01
Ionic H8 H 317 8x48 s5s6 E 65 N.s5s6.06
Polar H8 H 317 8x48 s5s6 E 65 N.s5s6.06
Hydrophobic H8 H 317 8x48 s5s6 E 65 N.s5s6.06
Van-der-waals H8 H 317 8x48 s5s6 E 65 N.s5s6.06
Hydrophobic TM3 I 146 3x54 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 I 146 3x54 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 A 149 34x50 s8s9 G 134 N.s8s9.08
Van-der-waals ICL2 A 149 34x50 s8s9 G 134 N.s8s9.08
Hydrophobic TM3 E 145 3x53 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 E 145 3x53 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 P 151 34x52 s8s9 P 136 N.s8s9.10
Hydrophobic TM6 A 248 6x33 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 A 248 6x33 s5s6 I 67 N.s5s6.08
Hydrophobic ICL3 P 242 - s5s6 L 69 N.s5s6.10
Ionic H8 R 318 8x49 s5s6 D 63 N.s5s6.04
Polar H8 R 318 8x49 s5s6 D 63 N.s5s6.04
Hydrophobic H8 R 318 8x49 s5s6 D 63 N.s5s6.04
Van-der-waals H8 R 318 8x49 s5s6 D 63 N.s5s6.04
Hydrophobic TM6 A 248 6x33 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 A 248 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic TM5 I 233 5x61 s5s6 I 67 N.s5s6.08
Polar H8 S 316 8x47 s5s6 V 66 N.s5s6.07
Hydrophobic H8 S 316 8x47 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 A 149 34x50 S5 Y 59 N.S5.12
Van-der-waals ICL2 A 149 34x50 S5 Y 59 N.S5.12
Hydrophobic TM5 R 239 5x67 s15s16 L 243 C.s15s16.05
Van-der-waals TM5 R 239 5x67 s15s16 L 243 C.s15s16.05
Polar TM7 S 315 7x56 s5s6 G 68 N.s5s6.09
Van-der-waals TM7 S 315 7x56 s5s6 G 68 N.s5s6.09