Beta-arrestin-2 - ACKR3 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ACKR3 75.6
Beta-arrestin-2 77.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 23.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Ionic TM4 R 161 4x42 s5s6 D 70 N.s5s6.06
Polar TM4 R 161 4x42 s5s6 D 70 N.s5s6.06
Hydrophobic TM4 R 161 4x42 s5s6 D 70 N.s5s6.06
Van-der-waals TM4 R 161 4x42 s5s6 D 70 N.s5s6.06
Hydrophobic H8 Y 324 8x52 s15s16 S 246 C.s15s16.04
Van-der-waals H8 Y 324 8x52 s15s16 S 246 C.s15s16.04
Polar TM3 T 147 3x55 s20c Y 404 C.s20c.14
Polar TM3 S 145 3x53 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 S 145 3x53 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 S 145 3x53 s5s6 D 68 N.s5s6.04
Polar ICL2 N 151 - s20c Y 404 C.s20c.14
Van-der-waals ICL2 N 151 - s20c Y 404 C.s20c.14
Hydrophobic TM6 Q 245 6x28 s8s9 E 135 N.s8s9.05
Van-der-waals TM6 Q 245 6x28 s8s9 E 135 N.s8s9.05
Hydrophobic TM3 S 145 3x53 s5s6 V 71 N.s5s6.07
Hydrophobic H8 R 320 8x48 s15s16 F 245 C.s15s16.03
Polar TM6 Q 245 6x28 s8s9 D 136 N.s8s9.06
Hydrophobic TM6 Q 245 6x28 s8s9 D 136 N.s8s9.06
Van-der-waals TM6 Q 245 6x28 s8s9 D 136 N.s8s9.06
Hydrophobic H8 Y 324 8x52 s15s16 L 244 C.s15s16.02
Hydrophobic TM2 H 80 2x40 s5s6 V 71 N.s5s6.07
Polar TM6 Q 245 6x28 s8s9 P 134 N.s8s9.04
Hydrophobic TM6 Q 245 6x28 s8s9 P 134 N.s8s9.04
Van-der-waals TM6 Q 245 6x28 s8s9 P 134 N.s8s9.04
Hydrophobic TM6 Q 245 6x28 s8s9 P 132 N.s8s9.02
Van-der-waals TM6 Q 245 6x28 s8s9 P 132 N.s8s9.02
Polar H8 Y 324 8x52 s15s16 C 243 C.s15s16.01
Van-der-waals H8 Y 324 8x52 s15s16 C 243 C.s15s16.01
Polar ICL2 N 151 - s20c Q 407 C.s20c.17
Hydrophobic ICL2 N 151 - s20c Q 407 C.s20c.17
Van-der-waals ICL2 N 151 - s20c Q 407 C.s20c.17
Polar ICL2 N 151 - s9s10 K 161 N.s9s10.12
Van-der-waals ICL2 N 151 - s9s10 K 161 N.s9s10.12
Polar H8 N 319 8x47 s5s6 G 73 N.s5s6.09
Polar TM3 R 142 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 R 142 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 142 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic H8 N 321 8x49 S5 Y 64 N.S5.12
Van-der-waals H8 N 321 8x49 S5 Y 64 N.S5.12
Polar TM6 Q 245 6x28 s8s9 G 133 N.s8s9.03
Hydrophobic TM6 Q 245 6x28 s8s9 G 133 N.s8s9.03
Van-der-waals TM6 Q 245 6x28 s8s9 G 133 N.s8s9.03
Polar TM2 H 80 2x40 s5s6 G 73 N.s5s6.09
Hydrophobic TM2 H 80 2x40 s5s6 G 73 N.s5s6.09
Van-der-waals TM2 H 80 2x40 s5s6 G 73 N.s5s6.09
Van-der-waals ICL3 D 244 - s5s6 L 69 N.s5s6.05
Polar H8 Y 324 8x52 s15s16 F 245 C.s15s16.03
Aromatic H8 Y 324 8x52 s15s16 F 245 C.s15s16.03
Hydrophobic H8 Y 324 8x52 s15s16 F 245 C.s15s16.03
Van-der-waals H8 Y 324 8x52 s15s16 F 245 C.s15s16.03
Hydrophobic H8 N 321 8x49 s15s16 F 245 C.s15s16.03
Van-der-waals H8 N 321 8x49 s15s16 F 245 C.s15s16.03
Hydrophobic C-term K 362 - s11s12 L 192 C.s11s12.02
Hydrophobic H8 Y 324 8x52 s15s16 T 247 C.s15s16.05
Van-der-waals ICL1 G 76 12x51 S6 R 77 N.S6.02
Hydrophobic H8 R 320 8x48 s5s6 L 74 N.s5s6.10
Polar TM3 I 146 3x54 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 I 146 3x54 s5s6 D 68 N.s5s6.04
Polar H8 N 319 8x47 s5s6 L 72 N.s5s6.08
Hydrophobic H8 N 319 8x47 s5s6 L 72 N.s5s6.08
Van-der-waals H8 N 319 8x47 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 E 246 6x29 s8s9 T 137 N.s8s9.07
Van-der-waals TM6 E 246 6x29 s8s9 T 137 N.s8s9.07
Hydrophobic TM6 I 253 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic H8 N 319 8x47 s5s6 L 74 N.s5s6.10
Van-der-waals H8 N 319 8x47 s5s6 L 74 N.s5s6.10
Polar TM2 Y 77 2x37 S6 R 77 N.S6.02
Hydrophobic TM3 I 146 3x54 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 I 146 3x54 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 P 153 - s9s10 K 161 N.s9s10.12
Van-der-waals ICL2 P 153 - s9s10 K 161 N.s9s10.12
Hydrophobic H8 K 328 8x56 s15s16 L 244 C.s15s16.02
Van-der-waals H8 K 328 8x56 s15s16 L 244 C.s15s16.02
Hydrophobic ICL2 T 150 - s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 T 150 - s5s6 D 68 N.s5s6.04
Ionic ICL2 K 157 - s5s6 D 68 N.s5s6.04
Ionic TM2 H 80 2x40 s5s6 D 70 N.s5s6.06
Polar TM2 H 80 2x40 s5s6 D 70 N.s5s6.06
Hydrophobic TM2 H 80 2x40 s5s6 D 70 N.s5s6.06
Van-der-waals TM2 H 80 2x40 s5s6 D 70 N.s5s6.06
Polar ICL2 N 151 - s20c L 408 C.s20c.18
Ionic ICL3 D 244 - s5s6 R 66 N.s5s6.02
Polar ICL3 D 244 - s5s6 R 66 N.s5s6.02
Hydrophobic H8 F 332 8x60 s17s18 E 314 C.s17s18.39
Van-der-waals H8 F 332 8x60 s17s18 E 314 C.s17s18.39
Hydrophobic TM2 Y 77 2x37 s15s16 F 245 C.s15s16.03
Van-der-waals TM2 Y 77 2x37 s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 T 150 - s20c Y 404 C.s20c.14
Van-der-waals ICL2 T 150 - s20c Y 404 C.s20c.14
Aromatic TM2 Y 77 2x37 S6 F 76 N.S6.01
Hydrophobic TM2 Y 77 2x37 S6 F 76 N.S6.01
Van-der-waals TM2 Y 77 2x37 S6 F 76 N.S6.01
Hydrophobic TM5 L 235 5x61 s5s6 V 71 N.s5s6.07
Van-der-waals TM5 L 235 5x61 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 Y 257 6x40 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 Y 257 6x40 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 I 146 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 I 146 3x54 s5s6 L 69 N.s5s6.05
Polar TM3 R 142 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 R 142 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 142 3x50 s5s6 V 71 N.s5s6.07
Polar H8 R 320 8x48 s8s9 T 137 N.s8s9.07
Hydrophobic H8 R 320 8x48 s8s9 T 137 N.s8s9.07
Van-der-waals H8 R 320 8x48 s8s9 T 137 N.s8s9.07
Polar H8 N 321 8x49 s5s6 L 74 N.s5s6.10
Hydrophobic H8 N 321 8x49 s5s6 L 74 N.s5s6.10
Van-der-waals H8 N 321 8x49 s5s6 L 74 N.s5s6.10
Hydrophobic H8 E 325 8x53 s15s16 F 245 C.s15s16.03