S-arrestin - ACKR3 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ACKR3 76.8
S-arrestin 77.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 23.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic H8 K 328 8x56 S6 F 83 N.S6.01
Polar ICL3 S 243 - s8s9 Q 141 N.s8s9.05
Hydrophobic ICL3 S 243 - s8s9 Q 141 N.s8s9.05
Van-der-waals ICL3 S 243 - s8s9 Q 141 N.s8s9.05
Hydrophobic TM3 R 142 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 142 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic H8 R 320 8x48 s15s16 Y 254 C.s15s16.03
Van-der-waals H8 R 320 8x48 s15s16 Y 254 C.s15s16.03
Polar TM2 Y 77 2x37 S6 F 83 N.S6.01
Aromatic TM2 Y 77 2x37 S6 F 83 N.S6.01
Hydrophobic TM2 Y 77 2x37 S6 F 83 N.S6.01
Van-der-waals TM2 Y 77 2x37 S6 F 83 N.S6.01
Hydrophobic TM3 S 145 3x53 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 S 145 3x53 s5s6 V 78 N.s5s6.07
Polar H8 N 319 8x47 s5s6 G 80 N.s5s6.09
Hydrophobic ICL3 D 244 - s8s9 A 139 N.s8s9.03
Van-der-waals ICL3 D 244 - s8s9 A 139 N.s8s9.03
Hydrophobic TM3 I 146 3x54 s5s6 I 76 N.s5s6.05
Polar ICL3 D 244 - s8s9 D 142 N.s8s9.06
Hydrophobic ICL3 D 244 - s8s9 D 142 N.s8s9.06
Van-der-waals ICL3 D 244 - s8s9 D 142 N.s8s9.06
Polar H8 N 321 8x49 s5s6 T 82 N.s5s6.11
Van-der-waals H8 N 321 8x49 s5s6 T 82 N.s5s6.11
Aromatic H8 Y 324 8x52 s15s16 Y 254 C.s15s16.03
Hydrophobic H8 Y 324 8x52 s15s16 Y 254 C.s15s16.03
Van-der-waals H8 Y 324 8x52 s15s16 Y 254 C.s15s16.03
Aromatic H8 Y 324 8x52 S6 F 83 N.S6.01
Hydrophobic H8 Y 324 8x52 S6 F 83 N.S6.01
Van-der-waals H8 Y 324 8x52 S6 F 83 N.S6.01
Hydrophobic TM2 T 79 2x39 s5s6 G 80 N.s5s6.09
Van-der-waals TM2 T 79 2x39 s5s6 G 80 N.s5s6.09
Hydrophobic H8 E 325 8x53 S6 F 83 N.S6.01
Van-der-waals H8 E 325 8x53 S6 F 83 N.S6.01
Polar TM5 S 242 5x68 s8s9 Q 141 N.s8s9.05
Hydrophobic TM5 S 242 5x68 s8s9 Q 141 N.s8s9.05
Van-der-waals TM5 S 242 5x68 s8s9 Q 141 N.s8s9.05
Polar H8 E 325 8x53 s15s16 Y 254 C.s15s16.03
Polar H8 R 320 8x48 S5 Y 71 N.S5.12
Hydrophobic H8 R 320 8x48 S5 Y 71 N.S5.12
Van-der-waals H8 R 320 8x48 S5 Y 71 N.S5.12
Polar H8 N 321 8x49 s5s6 L 81 N.s5s6.10
Hydrophobic H8 N 321 8x49 s5s6 L 81 N.s5s6.10
Van-der-waals H8 N 321 8x49 s5s6 L 81 N.s5s6.10
Polar TM2 H 80 2x40 s5s6 G 80 N.s5s6.09
Hydrophobic TM2 H 80 2x40 s5s6 G 80 N.s5s6.09
Van-der-waals TM2 H 80 2x40 s5s6 G 80 N.s5s6.09
Polar TM2 Y 77 2x37 S6 R 84 N.S6.02
Hydrophobic TM2 Y 77 2x37 S6 R 84 N.S6.02
Van-der-waals TM2 Y 77 2x37 S6 R 84 N.S6.02
Polar TM2 Y 77 2x37 S6 R 85 N.S6.03
Van-der-waals TM2 Y 77 2x37 S6 R 85 N.S6.03
Polar H8 N 321 8x49 s5s6 G 80 N.s5s6.09
Hydrophobic H8 N 321 8x49 s5s6 G 80 N.s5s6.09
Van-der-waals H8 N 321 8x49 s5s6 G 80 N.s5s6.09
Van-der-waals TM4 R 161 4x42 s5s6 V 78 N.s5s6.07
Hydrophobic H8 K 328 8x56 S6 R 85 N.S6.03
Van-der-waals H8 K 328 8x56 S6 R 85 N.S6.03
Hydrophobic ICL2 T 150 - s5s6 D 75 N.s5s6.04
Van-der-waals ICL2 T 150 - s5s6 D 75 N.s5s6.04
Hydrophobic H8 N 321 8x49 S5 Y 71 N.S5.12
Van-der-waals H8 N 321 8x49 S5 Y 71 N.S5.12
Hydrophobic TM2 T 79 2x39 s5s6 D 77 N.s5s6.06
Van-der-waals TM2 T 79 2x39 s5s6 D 77 N.s5s6.06
Hydrophobic TM2 Y 77 2x37 s5s6 T 82 N.s5s6.11
Van-der-waals TM2 Y 77 2x37 s5s6 T 82 N.s5s6.11
Ionic ICL3 D 244 - s17s18 R 295 C.s17s18.11
Polar ICL3 D 244 - s17s18 R 295 C.s17s18.11
Hydrophobic ICL3 D 244 - s17s18 R 295 C.s17s18.11
Van-der-waals ICL3 D 244 - s17s18 R 295 C.s17s18.11
Van-der-waals H8 R 320 8x48 s8s9 K 145 N.s8s9.09
Hydrophobic TM3 R 142 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 142 3x50 s5s6 V 78 N.s5s6.07
Polar H8 N 319 8x47 s5s6 I 79 N.s5s6.08
Van-der-waals H8 N 319 8x47 s5s6 I 79 N.s5s6.08
Polar H8 Y 324 8x52 S6 R 85 N.S6.03
Hydrophobic H8 Y 324 8x52 S6 R 85 N.S6.03
Van-der-waals H8 Y 324 8x52 S6 R 85 N.S6.03
Polar H8 R 320 8x48 S16 Y 259 C.S16.03
Hydrophobic TM3 D 141 3x49 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 D 141 3x49 s5s6 V 78 N.s5s6.07
Polar TM6 E 246 6x29 s8s9 D 142 N.s8s9.06
Hydrophobic TM6 E 246 6x29 s8s9 D 142 N.s8s9.06
Van-der-waals TM6 E 246 6x29 s8s9 D 142 N.s8s9.06
Polar TM2 H 80 2x40 s5s6 I 79 N.s5s6.08
Hydrophobic TM2 H 80 2x40 s5s6 I 79 N.s5s6.08
Van-der-waals TM2 H 80 2x40 s5s6 I 79 N.s5s6.08
Ionic H8 R 320 8x48 S16 D 257 C.S16.01
Polar H8 R 320 8x48 S16 D 257 C.S16.01
Hydrophobic H8 R 320 8x48 S16 D 257 C.S16.01
Van-der-waals H8 R 320 8x48 S16 D 257 C.S16.01
Hydrophobic H8 N 319 8x47 s5s6 L 81 N.s5s6.10
Van-der-waals H8 N 319 8x47 s5s6 L 81 N.s5s6.10
Hydrophobic H8 Y 324 8x52 s15s16 L 253 C.s15s16.02
Van-der-waals H8 Y 324 8x52 s15s16 L 253 C.s15s16.02
Hydrophobic C-term L 340 - s17s18 D 321 C.s17s18.37
Van-der-waals C-term L 340 - s17s18 D 321 C.s17s18.37
Hydrophobic TM3 I 146 3x54 s5s6 V 78 N.s5s6.07
Ionic TM6 E 246 6x29 s8s9 K 145 N.s8s9.09
Polar TM6 E 246 6x29 s8s9 K 145 N.s8s9.09
Hydrophobic TM6 E 246 6x29 s8s9 K 145 N.s8s9.09
Van-der-waals TM6 E 246 6x29 s8s9 K 145 N.s8s9.09
Polar H8 N 321 8x49 s15s16 Y 254 C.s15s16.03
Hydrophobic H8 N 321 8x49 s15s16 Y 254 C.s15s16.03
Van-der-waals H8 N 321 8x49 s15s16 Y 254 C.s15s16.03
Hydrophobic H8 N 321 8x49 S6 F 83 N.S6.01
Van-der-waals H8 N 321 8x49 S6 F 83 N.S6.01
Polar ICL3 D 244 - s8s9 Q 141 N.s8s9.05
Hydrophobic ICL3 D 244 - s8s9 Q 141 N.s8s9.05
Van-der-waals ICL3 D 244 - s8s9 Q 141 N.s8s9.05