Arrestin-C - ACKR4 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ACKR4 75.1
Arrestin-C 80.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM2 T 74 2x37 s5s6 D 62 N.s5s6.03
Van-der-waals TM2 T 74 2x37 s5s6 D 62 N.s5s6.03
Hydrophobic TM6 I 233 6x28 S6 F 71 N.S6.01
Van-der-waals TM6 I 233 6x28 S6 F 71 N.S6.01
Hydrophobic TM3 V 141 3x54 s5s6 I 67 N.s5s6.08
Polar ICL1 Q 72 12x50 s8s9 P 130 N.s8s9.04
Hydrophobic ICL1 Q 72 12x50 s8s9 P 130 N.s8s9.04
Van-der-waals ICL1 Q 72 12x50 s8s9 P 130 N.s8s9.04
Hydrophobic H8 M 315 8x55 s20c E 383 C.s20c.17
Van-der-waals H8 M 315 8x55 s20c E 383 C.s20c.17
Polar TM3 K 143 3x56 s5s6 R 61 N.s5s6.02
Van-der-waals TM3 K 143 3x56 s5s6 R 61 N.s5s6.02
Polar TM2 T 74 2x37 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 T 74 2x37 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 T 74 2x37 s5s6 D 63 N.s5s6.04
Polar ICL1 Q 72 12x50 s17s18 R 282 C.s17s18.11
Polar TM3 R 137 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 R 137 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 137 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 P 145 - S5 Y 59 N.S5.12
Van-der-waals ICL2 P 145 - S5 Y 59 N.S5.12
Polar H8 A 308 8x48 s5s6 E 65 N.s5s6.06
Hydrophobic H8 A 308 8x48 s5s6 E 65 N.s5s6.06
Van-der-waals H8 A 308 8x48 s5s6 E 65 N.s5s6.06
Polar ICL1 Q 72 12x50 s8s9 G 129 N.s8s9.03
Hydrophobic ICL1 Q 72 12x50 s8s9 G 129 N.s8s9.03
Van-der-waals ICL1 Q 72 12x50 s8s9 G 129 N.s8s9.03
Hydrophobic H8 M 315 8x55 s20c V 380 C.s20c.13
Hydrophobic TM7 M 306 7x56 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 M 306 7x56 s5s6 V 66 N.s5s6.07
Ionic H8 K 311 8x51 s20c E 383 C.s20c.17
Polar H8 K 311 8x51 s20c E 383 C.s20c.17
Hydrophobic H8 K 311 8x51 s20c E 383 C.s20c.17
Van-der-waals H8 K 311 8x51 s20c E 383 C.s20c.17
Hydrophobic H8 M 315 8x55 s20c A 379 C.s20c.12
Van-der-waals H8 M 315 8x55 s20c A 379 C.s20c.12
Polar ICL1 Q 72 12x50 s8s9 D 132 N.s8s9.06
Hydrophobic TM5 M 230 5x68 S6 F 71 N.S6.01
Van-der-waals TM5 M 230 5x68 S6 F 71 N.S6.01
Hydrophobic H8 K 319 8x59 s20c A 382 C.s20c.15
Hydrophobic ICL2 Q 147 - s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 Q 147 - s8s9 A 133 N.s8s9.07
Hydrophobic TM3 A 140 3x53 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 I 80 2x43 s5s6 V 66 N.s5s6.07
Van-der-waals ICL3 N 232 - S6 R 72 N.S6.02
Hydrophobic TM6 I 233 6x28 s15s16 Y 241 C.s15s16.03
Van-der-waals TM7 M 306 7x56 s5s6 E 65 N.s5s6.06
Polar TM3 A 140 3x53 s5s6 R 61 N.s5s6.02
Hydrophobic TM3 A 140 3x53 s5s6 R 61 N.s5s6.02
Van-der-waals TM3 A 140 3x53 s5s6 R 61 N.s5s6.02
Hydrophobic TM6 I 233 6x28 s5s6 L 69 N.s5s6.10
Hydrophobic TM3 V 141 3x54 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 V 141 3x54 s5s6 L 64 N.s5s6.05
Polar ICL3 N 232 - S6 D 74 N.S6.04
Polar TM7 M 306 7x56 s5s6 G 68 N.s5s6.09
Van-der-waals TM7 M 306 7x56 s5s6 G 68 N.s5s6.09
Hydrophobic TM3 A 140 3x53 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 A 140 3x53 s5s6 L 64 N.s5s6.05
Polar H8 G 307 8x47 s5s6 E 65 N.s5s6.06
Hydrophobic H8 G 307 8x47 s5s6 E 65 N.s5s6.06
Van-der-waals H8 G 307 8x47 s5s6 E 65 N.s5s6.06
Hydrophobic TM2 T 76 2x39 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 T 76 2x39 s5s6 V 66 N.s5s6.07
Polar H8 K 319 8x59 s20c K 378 C.s20c.11
Hydrophobic H8 K 319 8x59 s20c K 378 C.s20c.11
Van-der-waals H8 K 319 8x59 s20c K 378 C.s20c.11
Polar H8 S 309 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic H8 S 309 8x49 s5s6 E 65 N.s5s6.06
Van-der-waals H8 S 309 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic ICL2 P 145 - s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 P 145 - s15s16 S 242 C.s15s16.04
Ionic ICL1 K 70 12x48 s5s6 D 62 N.s5s6.03
Hydrophobic TM6 P 238 6x33 s5s6 G 68 N.s5s6.09
Hydrophobic TM3 R 137 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 137 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 V 241 6x36 s5s6 I 67 N.s5s6.08
Hydrophobic H8 G 307 8x47 s5s6 V 66 N.s5s6.07
Hydrophobic TM5 L 227 5x65 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 L 227 5x65 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 V 144 - s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 V 144 - s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 V 144 - s5s6 R 61 N.s5s6.02
Polar H8 K 319 8x59 s20c A 379 C.s20c.12
Hydrophobic H8 K 319 8x59 s20c A 379 C.s20c.12
Van-der-waals H8 K 319 8x59 s20c A 379 C.s20c.12
Van-der-waals TM6 P 238 6x33 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 P 238 6x33 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 P 238 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic TM3 V 141 3x54 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 P 145 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 P 145 - s5s6 R 61 N.s5s6.02