Arrestin-C - M1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
M1 82.4
Arrestin-C 82.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 222 5x72 S6 K 73 N.S6.03
Van-der-waals TM5 L 222 5x72 S6 K 73 N.S6.03
Polar ICL2 S 132 34x52 S16 D 244 C.S16.01
Hydrophobic ICL2 S 132 34x52 S16 D 244 C.S16.01
Van-der-waals ICL2 S 132 34x52 S16 D 244 C.S16.01
Hydrophobic TM3 R 123 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic H8 N 422 8x47 s5s6 V 66 N.s5s6.07
Polar ICL2 P 130 34x50 S5 Y 59 N.S5.12
Hydrophobic ICL2 P 130 34x50 S5 Y 59 N.S5.12
Van-der-waals ICL2 P 130 34x50 S5 Y 59 N.S5.12
Polar TM7 C 421 7x56 s5s6 V 66 N.s5s6.07
Hydrophobic TM7 C 421 7x56 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 C 421 7x56 s5s6 V 66 N.s5s6.07
Polar ICL3 Q 348 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL3 Q 348 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 Q 348 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL2 L 131 34x51 S8 L 126 N.S8.03
Van-der-waals ICL2 L 131 34x51 S8 L 126 N.S8.03
Polar H8 N 422 8x47 s5s6 D 62 N.s5s6.03
Polar ICL2 L 131 34x51 S16 D 244 C.S16.01
Hydrophobic ICL2 L 131 34x51 S16 D 244 C.S16.01
Van-der-waals ICL2 L 131 34x51 S16 D 244 C.S16.01
Hydrophobic TM6 A 363 6x33 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 A 363 6x33 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 L 225 5x75 s17s18 L 311 C.s17s18.40
Van-der-waals TM5 L 225 5x75 s17s18 L 311 C.s17s18.40
Hydrophobic TM6 A 363 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic TM5 R 218 5x68 S6 F 71 N.S6.01
Van-der-waals TM5 R 218 5x68 S6 F 71 N.S6.01
Polar TM2 N 60 2x39 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 N 60 2x39 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 N 60 2x39 s5s6 D 63 N.s5s6.04
Polar TM2 N 60 2x39 s5s6 R 61 N.s5s6.02
Van-der-waals TM2 N 60 2x39 s5s6 R 61 N.s5s6.02
Hydrophobic TM5 L 222 5x72 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 L 222 5x72 s15s16 Y 241 C.s15s16.03
Polar ICL2 P 130 34x50 S16 D 244 C.S16.01
Hydrophobic ICL2 P 130 34x50 S16 D 244 C.S16.01
Van-der-waals ICL2 P 130 34x50 S16 D 244 C.S16.01
Hydrophobic ICL2 L 131 34x51 S9 C 137 N.S9.01
Van-der-waals ICL2 L 131 34x51 S9 C 137 N.S9.01
Hydrophobic TM5 L 225 5x75 S6 K 73 N.S6.03
Van-der-waals TM5 L 225 5x75 S6 K 73 N.S6.03
Hydrophobic TM3 S 126 3x53 s5s6 L 64 N.s5s6.05
Polar TM6 K 359 6x29 s5s6 T 70 N.s5s6.11
Van-der-waals TM6 K 359 6x29 s5s6 T 70 N.s5s6.11
Hydrophobic TM3 V 127 3x54 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 V 127 3x54 s5s6 L 64 N.s5s6.05
Hydrophobic TM2 T 58 2x37 s8s9 A 133 N.s8s9.07
Hydrophobic ICL2 L 131 34x51 S15 V 238 C.S15.14
Van-der-waals ICL2 L 131 34x51 S15 V 238 C.S15.14
Polar C-term R 448 - s8s9 G 134 N.s8s9.08
Hydrophobic C-term R 448 - s8s9 G 134 N.s8s9.08
Van-der-waals C-term R 448 - s8s9 G 134 N.s8s9.08
Hydrophobic TM5 L 225 5x75 s15s16 L 240 C.s15s16.02
Hydrophobic TM5 R 218 5x68 s15s16 S 242 C.s15s16.04
Van-der-waals TM5 R 218 5x68 s15s16 S 242 C.s15s16.04
Polar ICL2 L 131 34x51 S5 Y 59 N.S5.12
Hydrophobic ICL2 L 131 34x51 S5 Y 59 N.S5.12
Van-der-waals ICL2 L 131 34x51 S5 Y 59 N.S5.12
Polar TM2 Y 62 2x41 s8s9 E 131 N.s8s9.05
Hydrophobic TM4 P 139 4x39 s8s9 E 131 N.s8s9.05
Van-der-waals TM4 P 139 4x39 s8s9 E 131 N.s8s9.05
Polar ICL3 Q 348 - s9s10 P 151 N.s9s10.03
Ionic ICL2 R 137 34x57 s5s6 D 63 N.s5s6.04
Polar ICL2 R 137 34x57 s5s6 D 63 N.s5s6.04
Hydrophobic TM3 R 129 3x56 S16 D 244 C.S16.01
Van-der-waals TM3 R 129 3x56 S16 D 244 C.S16.01
Polar TM5 R 218 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 R 218 5x68 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 R 218 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic C-term R 448 - s8s9 K 135 N.s8s9.09
Van-der-waals C-term R 448 - s8s9 K 135 N.s8s9.09
Hydrophobic ICL3 E 347 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 E 347 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL2 R 134 34x54 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 R 134 34x54 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 L 131 34x51 S16 Y 246 C.S16.03
Van-der-waals ICL2 L 131 34x51 S16 Y 246 C.S16.03
Polar TM5 E 221 5x71 S6 K 73 N.S6.03
Van-der-waals TM5 E 221 5x71 S6 K 73 N.S6.03
Hydrophobic ICL2 P 130 34x50 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 P 130 34x50 s15s16 S 242 C.s15s16.04
Hydrophobic TM5 I 211 5x61 s5s6 I 67 N.s5s6.08
Ionic ICL2 R 134 34x54 s8s9 D 132 N.s8s9.06
Polar ICL2 R 134 34x54 s8s9 D 132 N.s8s9.06
Hydrophobic ICL2 R 134 34x54 s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 R 134 34x54 s8s9 D 132 N.s8s9.06
Hydrophobic TM5 T 215 5x65 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 T 215 5x65 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 E 214 5x64 s15s16 Y 241 C.s15s16.03
Hydrophobic TM3 V 127 3x54 s5s6 I 67 N.s5s6.08
Polar TM5 E 221 5x71 s15s16 Y 241 C.s15s16.03
Hydrophobic TM6 L 367 6x37 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 L 367 6x37 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 S 132 34x52 S16 Y 246 C.S16.03
Hydrophobic C-term P 449 - s20c S 376 C.s20c.09
Van-der-waals ICL2 R 137 34x57 s5s6 R 61 N.s5s6.02
Hydrophobic ICL3 R 352 - S6 V 77 N.S6.07
Van-der-waals ICL3 R 352 - S6 V 77 N.S6.07
Hydrophobic TM3 R 123 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 123 3x50 s5s6 V 66 N.s5s6.07
Ionic ICL3 R 352 - S6 D 74 N.S6.04
Polar ICL3 R 352 - S6 D 74 N.S6.04
Hydrophobic ICL3 R 352 - S6 D 74 N.S6.04
Van-der-waals ICL3 R 352 - S6 D 74 N.S6.04
Polar TM3 T 128 3x55 s15s16 S 242 C.s15s16.04
Hydrophobic TM3 T 128 3x55 s15s16 S 242 C.s15s16.04
Van-der-waals TM3 T 128 3x55 s15s16 S 242 C.s15s16.04
Ionic ICL3 K 351 - s9s10 E 152 N.s9s10.07
Polar ICL3 K 351 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL3 K 351 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 K 351 - s9s10 E 152 N.s9s10.07