Beta-arrestin-2 - M2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
M2 84.2
Beta-arrestin-2 81.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 P 128 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 128 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 128 34x50 S5 Y 64 N.S5.12
Polar TM6 R 381 6x29 s5s6 S 75 N.s5s6.11
Hydrophobic TM6 R 381 6x29 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 R 381 6x29 s5s6 S 75 N.s5s6.11
Hydrophobic TM5 I 209 5x61 s5s6 L 74 N.s5s6.10
Polar TM5 R 216 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 R 216 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 R 216 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM3 V 125 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 V 125 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals ICL2 R 135 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic H8 N 444 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 V 133 34x55 S16 Y 250 C.S16.03
Van-der-waals ICL2 V 133 34x55 S16 Y 250 C.S16.03
Ionic TM5 D 220 5x72 S6 K 78 N.S6.03
Polar TM5 D 220 5x72 S6 K 78 N.S6.03
Hydrophobic TM5 D 220 5x72 S6 K 78 N.S6.03
Van-der-waals TM5 D 220 5x72 S6 K 78 N.S6.03
Polar TM2 T 56 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 T 56 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 T 56 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 L 129 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 L 129 34x51 S16 A 248 C.S16.01
Hydrophobic TM5 I 209 5x61 s5s6 L 72 N.s5s6.08
Hydrophobic TM4 T 137 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 T 137 4x39 s8s9 E 135 N.s8s9.05
Polar ICL1 H 53 12x49 s8s9 T 137 N.s8s9.07
Hydrophobic ICL1 H 53 12x49 s8s9 T 137 N.s8s9.07
Ionic ICL1 H 53 12x49 s20c D 402 C.s20c.12
Hydrophobic ICL1 H 53 12x49 s20c D 402 C.s20c.12
Van-der-waals ICL1 H 53 12x49 s20c D 402 C.s20c.12
Hydrophobic TM3 V 125 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 V 125 3x54 s5s6 L 74 N.s5s6.10
Polar TM6 R 381 6x29 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 R 381 6x29 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 R 381 6x29 s5s6 L 74 N.s5s6.10
Polar C-term R 466 - s20c D 402 C.s20c.12
Hydrophobic TM3 V 125 3x54 S6 F 76 N.S6.01
Aromatic TM6 R 381 6x29 S6 F 76 N.S6.01
Hydrophobic TM6 R 381 6x29 S6 F 76 N.S6.01
Van-der-waals TM6 R 381 6x29 S6 F 76 N.S6.01
Hydrophobic TM3 R 121 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 121 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 V 385 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 V 385 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic C-term G 463 - s20c Y 404 C.s20c.14
Hydrophobic ICL2 L 129 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 L 129 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 R 121 3x50 s5s6 L 72 N.s5s6.08
Ionic TM5 K 219 5x71 s17s18 E 314 C.s17s18.39
Polar TM5 K 219 5x71 s17s18 E 314 C.s17s18.39
Van-der-waals TM5 K 219 5x71 s17s18 E 314 C.s17s18.39
Polar ICL2 L 129 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 129 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 129 34x51 S16 Y 250 C.S16.03
Van-der-waals TM6 V 385 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM2 N 58 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 N 58 2x39 s5s6 D 68 N.s5s6.04
Ionic C-term R 466 - s20c D 403 C.s20c.13
Polar C-term R 466 - s20c D 403 C.s20c.13
Hydrophobic C-term R 466 - s20c D 403 C.s20c.13
Van-der-waals C-term R 466 - s20c D 403 C.s20c.13
Hydrophobic ICL1 R 52 12x48 s20c K 400 C.s20c.10
Van-der-waals ICL1 R 52 12x48 s20c K 400 C.s20c.10
Hydrophobic ICL2 P 128 34x50 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 P 128 34x50 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 C 124 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic TM5 S 213 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 S 213 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 T 130 34x52 S16 A 248 C.S16.01
Van-der-waals ICL2 T 130 34x52 S16 A 248 C.S16.01
Hydrophobic TM6 K 384 6x32 s5s6 G 73 N.s5s6.09
Hydrophobic ICL2 L 129 34x51 S9 C 141 N.S9.01
Hydrophobic ICL2 L 129 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 129 34x51 S15 I 242 C.S15.14
Hydrophobic C-term A 464 - s20c Y 404 C.s20c.14
Van-der-waals C-term A 464 - s20c Y 404 C.s20c.14
Polar ICL2 L 129 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 L 129 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 L 129 34x51 S5 Y 64 N.S5.12
Polar ICL2 P 132 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 P 132 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 P 132 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic TM6 I 389 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 T 388 6x36 s5s6 L 72 N.s5s6.08
Aromatic TM5 R 216 5x68 S6 F 76 N.S6.01
Hydrophobic TM5 R 216 5x68 S6 F 76 N.S6.01
Van-der-waals TM5 R 216 5x68 S6 F 76 N.S6.01
Polar TM7 C 443 7x56 s5s6 V 71 N.s5s6.07
Hydrophobic TM7 C 443 7x56 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 C 443 7x56 s5s6 V 71 N.s5s6.07
Ionic C-term R 466 - s20c D 405 C.s20c.15
Polar C-term R 466 - s20c D 405 C.s20c.15
Van-der-waals C-term R 466 - s20c D 405 C.s20c.15
Polar TM6 R 381 6x29 s5s6 G 73 N.s5s6.09
Ionic ICL2 R 135 34x57 s5s6 D 68 N.s5s6.04
Polar ICL2 R 135 34x57 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 T 56 2x37 s8s9 T 137 N.s8s9.07
Van-der-waals TM2 T 56 2x37 s8s9 T 137 N.s8s9.07