S-arrestin - M2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
M2 85.5
S-arrestin 82.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 S 213 5x65 S6 F 83 N.S6.01
Hydrophobic TM6 R 381 6x29 s5s6 L 81 N.s5s6.10
Hydrophobic H8 N 444 8x47 s5s6 G 80 N.s5s6.09
Hydrophobic ICL2 L 129 34x51 S8 L 136 N.S8.03
Van-der-waals ICL2 L 129 34x51 S8 L 136 N.S8.03
Polar TM3 R 121 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 R 121 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 121 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM5 I 209 5x61 s5s6 I 79 N.s5s6.08
Hydrophobic TM5 R 216 5x68 s17s18 L 325 C.s17s18.41
Van-der-waals TM5 R 216 5x68 s17s18 L 325 C.s17s18.41
Hydrophobic TM6 I 389 6x37 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 L 129 34x51 S5 Y 71 N.S5.12
Polar TM2 N 58 2x39 s5s6 D 75 N.s5s6.04
Hydrophobic TM6 T 388 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 T 388 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 P 128 34x50 S15 V 251 C.S15.14
Hydrophobic TM5 R 216 5x68 S6 R 85 N.S6.03
Van-der-waals TM5 R 216 5x68 S6 R 85 N.S6.03
Polar ICL2 T 130 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 T 130 34x52 S16 D 257 C.S16.01
Van-der-waals ICL2 T 130 34x52 S16 D 257 C.S16.01
Polar TM5 H 208 5x60 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 H 208 5x60 s15s16 Y 254 C.s15s16.03
Polar TM5 K 214 5x66 S6 R 85 N.S6.03
Van-der-waals TM5 K 214 5x66 S6 R 85 N.S6.03
Hydrophobic TM5 I 217 5x69 S6 F 89 N.S6.07
Polar ICL2 T 130 34x52 S16 Y 259 C.S16.03
Hydrophobic ICL2 T 130 34x52 S16 Y 259 C.S16.03
Van-der-waals ICL2 T 130 34x52 S16 Y 259 C.S16.03
Hydrophobic TM3 V 125 3x54 s5s6 I 76 N.s5s6.05
Hydrophobic TM5 I 217 5x69 S6 Y 88 N.S6.06
Van-der-waals TM5 I 217 5x69 S6 Y 88 N.S6.06
Hydrophobic TM3 C 124 3x53 s5s6 I 76 N.s5s6.05
Hydrophobic TM5 R 211 5x63 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 P 377 6x25 s9s10 E 164 N.s9s10.06
Van-der-waals TM6 P 377 6x25 s9s10 E 164 N.s9s10.06
Polar TM6 P 378 6x26 s9s10 E 164 N.s9s10.06
Hydrophobic TM6 P 378 6x26 s9s10 E 164 N.s9s10.06
Van-der-waals TM6 P 378 6x26 s9s10 E 164 N.s9s10.06
Polar TM6 R 381 6x29 s5s6 T 82 N.s5s6.11
Hydrophobic TM6 R 381 6x29 s5s6 T 82 N.s5s6.11
Van-der-waals TM6 R 381 6x29 s5s6 T 82 N.s5s6.11
Polar TM6 K 384 6x32 s5s6 G 80 N.s5s6.09
Hydrophobic TM7 C 443 7x56 s5s6 G 80 N.s5s6.09
Hydrophobic TM2 T 56 2x37 s5s6 D 75 N.s5s6.04
Van-der-waals TM2 T 56 2x37 s5s6 D 75 N.s5s6.04
Hydrophobic TM5 A 212 5x64 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 A 212 5x64 s15s16 Y 254 C.s15s16.03
Polar TM5 S 215 5x67 S6 D 86 N.S6.04
Van-der-waals TM5 S 215 5x67 S6 D 86 N.S6.04
Ionic C-term R 466 - s20c E 395 C.s20c.14
Polar C-term R 466 - s20c E 395 C.s20c.14
Van-der-waals C-term R 466 - s20c E 395 C.s20c.14
Hydrophobic TM3 T 126 3x55 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL2 L 129 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 L 129 34x51 S15 V 251 C.S15.14
Hydrophobic TM3 V 125 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 V 125 3x54 S6 F 83 N.S6.01
Polar TM3 C 124 3x53 S5 Y 71 N.S5.12
Hydrophobic TM3 C 124 3x53 S5 Y 71 N.S5.12
Van-der-waals TM3 C 124 3x53 S5 Y 71 N.S5.12
Hydrophobic TM6 R 381 6x29 S6 F 83 N.S6.01
Polar ICL2 L 129 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 L 129 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 L 129 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 P 128 34x50 s15s16 L 253 C.s15s16.02
Polar TM6 R 381 6x29 S6 R 84 N.S6.02
Hydrophobic TM6 R 381 6x29 S6 R 84 N.S6.02
Van-der-waals TM6 R 381 6x29 S6 R 84 N.S6.02
Hydrophobic TM6 P 378 6x26 s9s10 K 167 N.s9s10.09
Van-der-waals TM6 P 378 6x26 s9s10 K 167 N.s9s10.09
Polar H8 N 444 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic H8 N 444 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 N 444 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic TM5 S 215 5x67 S6 R 85 N.S6.03
Hydrophobic TM6 K 384 6x32 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 K 384 6x32 s5s6 L 81 N.s5s6.10
Hydrophobic TM5 I 217 5x69 S6 L 87 N.S6.05
Van-der-waals TM5 I 217 5x69 S6 L 87 N.S6.05
Hydrophobic TM6 V 385 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 R 121 3x50 s5s6 I 79 N.s5s6.08
Polar TM3 T 126 3x55 s15s16 S 255 C.s15s16.04
Van-der-waals TM3 T 126 3x55 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 P 132 34x54 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 132 34x54 S5 Y 71 N.S5.12
Hydrophobic TM3 I 117 3x46 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 P 132 34x54 s8s9 K 145 N.s8s9.09
Polar ICL2 P 128 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 P 128 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 128 34x50 S5 Y 71 N.S5.12
Hydrophobic TM6 V 385 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 V 385 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 L 129 34x51 S9 C 147 N.S9.01
Van-der-waals ICL2 L 129 34x51 S9 C 147 N.S9.01
Hydrophobic TM5 A 212 5x64 S6 F 83 N.S6.01
Hydrophobic TM5 I 217 5x69 S6 D 86 N.S6.04
Van-der-waals TM5 I 217 5x69 S6 D 86 N.S6.04