Beta-arrestin-1 - M3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
M3 78.0
Beta-arrestin-1 82.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 A 489 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 S 169 3x53 s5s6 L 68 N.s5s6.05
Polar TM6 K 485 6x29 s5s6 G 72 N.s5s6.09
Hydrophobic TM6 K 485 6x29 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 K 485 6x29 s5s6 G 72 N.s5s6.09
Hydrophobic ICL1 Q 98 12x49 s8s9 T 136 N.s8s9.07
Hydrophobic TM3 I 170 3x54 s5s6 L 71 N.s5s6.08
Polar ICL2 R 180 34x57 s17s18 R 285 C.s17s18.11
Van-der-waals ICL2 R 180 34x57 s17s18 R 285 C.s17s18.11
Hydrophobic ICL2 L 174 34x51 S15 I 241 C.S15.14
Polar TM2 V 102 2x38 s8s9 E 134 N.s8s9.05
Hydrophobic TM2 V 102 2x38 s8s9 E 134 N.s8s9.05
Van-der-waals TM2 V 102 2x38 s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 R 177 34x54 s5s6 R 65 N.s5s6.02
Polar ICL2 T 175 34x52 S16 Y 249 C.S16.03
Polar ICL3 Q 269 - S6 R 76 N.S6.02
Van-der-waals ICL3 Q 269 - S6 R 76 N.S6.02
Hydrophobic TM6 T 492 6x36 s5s6 V 70 N.s5s6.07
Ionic ICL2 R 177 34x54 s5s6 D 67 N.s5s6.04
Polar ICL2 R 177 34x54 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 R 177 34x54 s5s6 D 67 N.s5s6.04
Van-der-waals ICL2 R 177 34x54 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 L 174 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 L 174 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic TM5 R 261 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 R 261 5x68 s15s16 F 244 C.s15s16.03
Polar ICL3 S 271 - S6 K 77 N.S6.03
Van-der-waals ICL3 S 271 - S6 K 77 N.S6.03
Polar TM6 K 485 6x29 s5s6 T 74 N.s5s6.11
Van-der-waals TM6 K 485 6x29 s5s6 T 74 N.s5s6.11
Hydrophobic ICL2 A 178 34x55 s17s18 R 285 C.s17s18.11
Van-der-waals ICL2 A 178 34x55 s17s18 R 285 C.s17s18.11
Polar TM2 N 103 2x39 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 N 103 2x39 s5s6 D 67 N.s5s6.04
Hydrophobic TM6 L 493 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 I 170 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 I 170 3x54 s5s6 L 73 N.s5s6.10
Polar C-term Q 577 - S20 D 390 C.S20.05
Van-der-waals C-term Q 577 - S20 D 390 C.S20.05
Polar ICL2 L 174 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 L 174 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 L 174 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 A 178 34x55 S16 Y 249 C.S16.03
Hydrophobic ICL2 T 175 34x52 S16 A 247 C.S16.01
Hydrophobic TM5 L 268 5x75 S6 F 75 N.S6.01
Hydrophobic TM5 L 265 5x72 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 L 265 5x72 s15s16 F 244 C.s15s16.03
Polar TM6 K 488 6x32 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 K 488 6x32 s5s6 V 70 N.s5s6.07
Van-der-waals TM6 K 488 6x32 s5s6 V 70 N.s5s6.07
Polar H8 T 550 8x49 s5s6 E 66 N.s5s6.03
Hydrophobic TM3 I 170 3x54 s5s6 L 68 N.s5s6.05
Van-der-waals TM5 R 261 5x68 s15s16 N 245 C.s15s16.04
Hydrophobic TM2 T 101 2x37 s8s9 T 136 N.s8s9.07
Ionic ICL2 R 180 34x57 s8s9 D 135 N.s8s9.06
Polar ICL2 R 180 34x57 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 R 180 34x57 s8s9 D 135 N.s8s9.06
Polar TM6 K 488 6x32 s5s6 D 69 N.s5s6.06
Van-der-waals TM6 K 488 6x32 s5s6 D 69 N.s5s6.06
Hydrophobic ICL2 P 173 34x50 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 L 174 34x51 S9 C 140 N.S9.01
Hydrophobic ICL2 A 178 34x55 s17s18 G 286 C.s17s18.12
Hydrophobic ICL2 R 177 34x54 s5s6 L 68 N.s5s6.05
Van-der-waals ICL2 R 177 34x54 s5s6 L 68 N.s5s6.05
Hydrophobic TM4 T 181 4x38 s17s18 R 285 C.s17s18.11
Polar TM5 L 268 5x75 S6 K 77 N.S6.03
Hydrophobic TM5 L 268 5x75 S6 K 77 N.S6.03
Van-der-waals TM5 L 268 5x75 S6 K 77 N.S6.03
Ionic H8 K 549 8x48 s5s6 E 66 N.s5s6.03
Polar H8 K 549 8x48 s5s6 E 66 N.s5s6.03
Hydrophobic H8 K 549 8x48 s5s6 E 66 N.s5s6.03
Van-der-waals H8 K 549 8x48 s5s6 E 66 N.s5s6.03
Hydrophobic TM5 T 258 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic TM5 R 261 5x68 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 P 173 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 173 34x50 S5 Y 63 N.S5.12
Hydrophobic TM7 C 547 7x56 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 L 174 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 L 174 34x51 S8 L 129 N.S8.03
Hydrophobic ICL2 L 174 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 L 174 34x51 S16 A 247 C.S16.01
Hydrophobic TM4 T 182 4x39 s8s9 E 134 N.s8s9.05
Van-der-waals TM4 T 182 4x39 s8s9 E 134 N.s8s9.05
Hydrophobic TM5 I 254 5x61 s5s6 L 71 N.s5s6.08
Hydrophobic H8 N 548 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic TM5 L 268 5x75 s15s16 F 244 C.s15s16.03
Hydrophobic TM2 T 101 2x37 s8s9 E 134 N.s8s9.05
Van-der-waals TM2 T 101 2x37 s8s9 E 134 N.s8s9.05
Hydrophobic TM5 L 265 5x72 S6 F 75 N.S6.01
Van-der-waals TM5 L 265 5x72 S6 F 75 N.S6.01
Ionic C-term K 570 - s20c D 401 C.s20c.11
Polar C-term K 570 - s20c D 401 C.s20c.11
Van-der-waals C-term K 570 - s20c D 401 C.s20c.11
Hydrophobic ICL3 Q 269 - S6 F 75 N.S6.01
Hydrophobic TM5 L 268 5x75 s15s16 L 243 C.s15s16.02
Polar ICL2 R 177 34x54 s17s18 R 285 C.s17s18.11
Polar TM2 Y 105 2x41 s8s9 E 134 N.s8s9.05