Beta-arrestin-2 - M4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
M4 84.6
Beta-arrestin-2 80.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 18.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 V 134 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 V 134 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic TM5 S 222 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 S 222 5x65 s5s6 L 74 N.s5s6.10
Ionic C-term R 479 - s20c D 403 C.s20c.13
Polar C-term R 479 - s20c D 403 C.s20c.13
Van-der-waals C-term R 479 - s20c D 403 C.s20c.13
Polar TM6 R 394 6x29 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 R 394 6x29 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 R 394 6x29 s5s6 L 74 N.s5s6.10
Polar ICL2 P 141 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 P 141 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 P 141 34x54 s5s6 R 66 N.s5s6.02
Polar TM4 T 146 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 T 146 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 T 146 4x39 s8s9 E 135 N.s8s9.05
Aromatic TM6 R 394 6x29 S6 F 76 N.S6.01
Polar TM2 T 65 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 T 65 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 L 138 34x51 S9 C 141 N.S9.01
Hydrophobic TM6 V 398 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 V 398 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic C-term R 479 - s20c Y 404 C.s20c.14
Van-der-waals C-term R 479 - s20c Y 404 C.s20c.14
Hydrophobic ICL2 L 138 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 138 34x51 S15 I 242 C.S15.14
Hydrophobic TM3 R 130 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 A 142 34x55 S16 Y 250 C.S16.03
Van-der-waals ICL2 A 142 34x55 S16 Y 250 C.S16.03
Polar ICL3 R 386 - s9s10 E 156 N.s9s10.07
Hydrophobic ICL3 R 386 - s9s10 E 156 N.s9s10.07
Van-der-waals ICL3 R 386 - s9s10 E 156 N.s9s10.07
Hydrophobic ICL2 T 139 34x52 S16 A 248 C.S16.01
Van-der-waals ICL2 T 139 34x52 S16 A 248 C.S16.01
Hydrophobic TM3 C 133 3x53 s5s6 L 69 N.s5s6.05
Ionic ICL1 R 61 12x48 s20c D 402 C.s20c.12
Polar ICL1 R 61 12x48 s20c D 402 C.s20c.12
Hydrophobic TM3 V 134 3x54 S6 F 76 N.S6.01
Ionic ICL3 K 387 - S6 D 79 N.S6.04
Polar ICL3 K 387 - S6 D 79 N.S6.04
Hydrophobic ICL3 K 387 - S6 D 79 N.S6.04
Van-der-waals ICL3 K 387 - S6 D 79 N.S6.04
Polar C-term R 479 - s20c D 402 C.s20c.12
Hydrophobic TM6 I 402 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 V 398 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 V 398 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic C-term G 476 - s20c Y 404 C.s20c.14
Van-der-waals C-term G 476 - s20c Y 404 C.s20c.14
Polar ICL2 L 138 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 138 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 138 34x51 S16 Y 250 C.S16.03
Hydrophobic TM5 I 218 5x61 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 V 134 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 R 225 5x68 s15s16 F 245 C.s15s16.03
Aromatic TM5 R 225 5x68 S6 F 76 N.S6.01
Hydrophobic TM5 R 225 5x68 S6 F 76 N.S6.01
Van-der-waals TM5 R 225 5x68 S6 F 76 N.S6.01
Aromatic TM5 H 229 5x72 S6 K 78 N.S6.03
Hydrophobic TM5 H 229 5x72 S6 K 78 N.S6.03
Van-der-waals TM5 H 229 5x72 S6 K 78 N.S6.03
Polar TM6 R 394 6x29 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 R 394 6x29 s5s6 G 73 N.s5s6.09
Ionic C-term R 479 - s20c D 405 C.s20c.15
Polar C-term R 479 - s20c D 405 C.s20c.15
Hydrophobic C-term R 479 - s20c D 405 C.s20c.15
Van-der-waals C-term R 479 - s20c D 405 C.s20c.15
Hydrophobic TM2 N 67 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 N 67 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 L 138 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 L 138 34x51 s15s16 S 246 C.s15s16.04
Polar TM6 R 394 6x29 s5s6 S 75 N.s5s6.11
Hydrophobic TM6 R 394 6x29 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 R 394 6x29 s5s6 S 75 N.s5s6.11
Ionic ICL2 R 144 34x57 s5s6 D 68 N.s5s6.04
Polar ICL2 R 144 34x57 s5s6 D 68 N.s5s6.04
Polar ICL2 T 139 34x52 S16 Y 250 C.S16.03
Hydrophobic ICL2 T 139 34x52 S16 Y 250 C.S16.03
Polar ICL2 P 137 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 137 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 137 34x50 S5 Y 64 N.S5.12
Polar ICL2 L 138 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 L 138 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 L 138 34x51 S5 Y 64 N.S5.12
Hydrophobic TM6 T 401 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic ICL3 K 387 - S6 I 82 N.S6.07
Van-der-waals ICL3 K 387 - S6 I 82 N.S6.07
Hydrophobic ICL2 L 138 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 L 138 34x51 S16 A 248 C.S16.01
Hydrophobic TM3 R 130 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 130 3x50 s5s6 V 71 N.s5s6.07
Polar ICL3 R 386 - s9s10 L 155 N.s9s10.03
Van-der-waals ICL3 R 386 - s9s10 L 155 N.s9s10.03
Polar ICL1 Q 62 12x49 s8s9 T 137 N.s8s9.07
Hydrophobic ICL1 Q 62 12x49 s8s9 T 137 N.s8s9.07
Van-der-waals ICL1 Q 62 12x49 s8s9 T 137 N.s8s9.07
Hydrophobic TM2 T 65 2x37 s8s9 T 137 N.s8s9.07
Van-der-waals TM2 T 65 2x37 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 P 137 34x50 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 R 144 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic C-term T 477 - s20c Y 404 C.s20c.14