Arrestin-C - M4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
M4 84.6
Arrestin-C 81.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 138 34x51 S8 L 126 N.S8.03
Van-der-waals ICL2 L 138 34x51 S8 L 126 N.S8.03
Hydrophobic TM2 T 65 2x37 s8s9 A 133 N.s8s9.07
Polar TM3 R 130 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 R 130 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 130 3x50 s5s6 V 66 N.s5s6.07
Polar ICL2 P 141 34x54 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 P 141 34x54 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 P 141 34x54 s5s6 R 61 N.s5s6.02
Polar ICL2 P 137 34x50 S16 D 244 C.S16.01
Hydrophobic ICL2 P 137 34x50 S16 D 244 C.S16.01
Van-der-waals ICL2 P 137 34x50 S16 D 244 C.S16.01
Hydrophobic ICL2 L 138 34x51 S15 T 236 C.S15.12
Hydrophobic TM5 Y 215 5x58 s5s6 I 67 N.s5s6.08
Ionic ICL3 K 237 - s6h1 E 86 N.s6h1.03
Polar ICL3 K 237 - s6h1 E 86 N.s6h1.03
Hydrophobic ICL3 K 237 - s6h1 E 86 N.s6h1.03
Van-der-waals ICL3 K 237 - s6h1 E 86 N.s6h1.03
Hydrophobic ICL2 T 139 34x52 S16 Y 246 C.S16.03
Van-der-waals ICL2 T 139 34x52 S16 Y 246 C.S16.03
Hydrophobic TM2 L 71 2x43 s5s6 V 66 N.s5s6.07
Polar ICL2 L 138 34x51 S16 D 244 C.S16.01
Hydrophobic ICL2 L 138 34x51 S16 D 244 C.S16.01
Van-der-waals ICL2 L 138 34x51 S16 D 244 C.S16.01
Van-der-waals ICL2 P 141 34x54 S5 Y 59 N.S5.12
Hydrophobic TM5 I 218 5x61 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 L 138 34x51 S15 V 238 C.S15.14
Van-der-waals ICL2 L 138 34x51 S15 V 238 C.S15.14
Hydrophobic TM6 M 391 6x26 S6 D 74 N.S6.04
Hydrophobic TM6 M 391 6x26 S6 K 73 N.S6.03
Polar TM3 T 135 3x55 s15s16 S 242 C.s15s16.04
Hydrophobic TM3 T 135 3x55 s15s16 S 242 C.s15s16.04
Van-der-waals TM3 T 135 3x55 s15s16 S 242 C.s15s16.04
Polar ICL2 P 137 34x50 S5 Y 59 N.S5.12
Hydrophobic ICL2 P 137 34x50 S5 Y 59 N.S5.12
Van-der-waals ICL2 P 137 34x50 S5 Y 59 N.S5.12
Hydrophobic TM3 V 134 3x54 S6 F 71 N.S6.01
Van-der-waals TM3 V 134 3x54 S6 F 71 N.S6.01
Polar C-term R 479 - s20c S 376 C.s20c.09
Hydrophobic ICL2 T 139 34x52 S16 K 245 C.S16.02
Van-der-waals ICL2 T 139 34x52 S16 K 245 C.S16.02
Polar TM3 K 136 3x56 s15s16 S 242 C.s15s16.04
Hydrophobic TM6 R 394 6x29 S6 F 71 N.S6.01
Hydrophobic C-term T 477 - s20c E 383 C.s20c.17
Van-der-waals C-term T 477 - s20c E 383 C.s20c.17
Hydrophobic ICL2 L 138 34x51 S16 Y 246 C.S16.03
Van-der-waals ICL2 L 138 34x51 S16 Y 246 C.S16.03
Hydrophobic TM6 V 398 6x33 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 V 398 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic TM3 V 134 3x54 S5 Y 59 N.S5.12
Polar ICL3 R 386 - s9s10 P 151 N.s9s10.03
Hydrophobic ICL3 R 386 - s9s10 P 151 N.s9s10.03
Van-der-waals ICL3 R 386 - s9s10 P 151 N.s9s10.03
Hydrophobic TM6 I 405 6x40 s5s6 I 67 N.s5s6.08
Hydrophobic TM2 T 65 2x37 s5s6 D 63 N.s5s6.04
Aromatic ICL3 K 387 - S6 Y 76 N.S6.06
Hydrophobic TM5 S 222 5x65 s15s16 Y 241 C.s15s16.03
Polar TM5 R 225 5x68 S6 K 73 N.S6.03
Hydrophobic TM5 R 225 5x68 S6 K 73 N.S6.03
Van-der-waals TM5 R 225 5x68 S6 K 73 N.S6.03
Hydrophobic H8 N 457 8x47 s5s6 E 65 N.s5s6.06
Hydrophobic C-term R 479 - s20c E 383 C.s20c.17
Van-der-waals C-term R 479 - s20c E 383 C.s20c.17
Polar TM6 R 394 6x29 s5s6 T 70 N.s5s6.11
Hydrophobic TM6 R 394 6x29 s5s6 T 70 N.s5s6.11
Van-der-waals TM6 R 394 6x29 s5s6 T 70 N.s5s6.11
Polar TM5 S 224 5x67 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 S 224 5x67 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 S 224 5x67 s15s16 Y 241 C.s15s16.03
Hydrophobic TM3 C 133 3x53 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 C 133 3x53 s5s6 L 64 N.s5s6.05
Hydrophobic TM5 A 221 5x64 S6 F 71 N.S6.01
Hydrophobic TM3 K 136 3x56 S16 D 244 C.S16.01
Van-der-waals TM3 K 136 3x56 S16 D 244 C.S16.01
Polar ICL3 R 386 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL3 R 386 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 R 386 - s9s10 E 152 N.s9s10.07
Hydrophobic C-term R 479 - s20c V 380 C.s20c.13
Van-der-waals C-term R 479 - s20c V 380 C.s20c.13
Ionic ICL2 R 144 34x57 s5s6 D 63 N.s5s6.04
Polar TM3 C 133 3x53 S5 Y 59 N.S5.12
Hydrophobic TM3 C 133 3x53 S5 Y 59 N.S5.12
Van-der-waals TM3 C 133 3x53 S5 Y 59 N.S5.12
Polar TM6 R 394 6x29 S6 R 72 N.S6.02
Hydrophobic TM6 R 394 6x29 S6 R 72 N.S6.02
Van-der-waals TM6 R 394 6x29 S6 R 72 N.S6.02
Hydrophobic TM5 R 223 5x66 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 S 224 5x67 S6 K 73 N.S6.03
Van-der-waals TM5 S 224 5x67 S6 K 73 N.S6.03
Polar ICL2 T 139 34x52 S16 D 244 C.S16.01
Hydrophobic ICL2 T 139 34x52 S16 D 244 C.S16.01
Van-der-waals ICL2 T 139 34x52 S16 D 244 C.S16.01
Hydrophobic TM5 S 222 5x65 S6 F 71 N.S6.01
Van-der-waals TM5 S 222 5x65 S6 F 71 N.S6.01
Hydrophobic ICL2 L 138 34x51 S9 C 137 N.S9.01
Van-der-waals ICL2 L 138 34x51 S9 C 137 N.S9.01
Hydrophobic TM3 V 134 3x54 s5s6 L 64 N.s5s6.05
Hydrophobic ICL2 P 137 34x50 S15 V 238 C.S15.14
Polar TM4 T 146 4x39 s8s9 E 131 N.s8s9.05
Van-der-waals TM4 T 146 4x39 s8s9 E 131 N.s8s9.05
Polar ICL3 R 386 - s9s10 E 153 N.s9s10.08
Van-der-waals ICL3 R 386 - s9s10 E 153 N.s9s10.08
Polar ICL3 N 383 - S6 T 79 N.S6.09
Hydrophobic TM2 N 67 2x39 s5s6 V 66 N.s5s6.07
Hydrophobic TM6 T 401 6x36 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 T 401 6x36 s5s6 I 67 N.s5s6.08
Hydrophobic TM2 N 67 2x39 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 N 67 2x39 s5s6 D 63 N.s5s6.04
Hydrophobic TM5 A 221 5x64 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 A 221 5x64 s15s16 Y 241 C.s15s16.03
Hydrophobic TM6 I 402 6x37 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 H 229 5x72 s7s8 V 117 N.s7s8.03
Van-der-waals ICL2 P 137 34x50 s15s16 S 242 C.s15s16.04
Hydrophobic TM5 H 227 5x70 s17s18 L 311 C.s17s18.40
Van-der-waals TM5 H 227 5x70 s17s18 L 311 C.s17s18.40
Hydrophobic TM3 R 130 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 130 3x50 s5s6 I 67 N.s5s6.08
Ionic TM5 H 227 5x70 s17s18 D 308 C.s17s18.37
Polar TM5 H 227 5x70 s17s18 D 308 C.s17s18.37
Van-der-waals TM5 H 227 5x70 s17s18 D 308 C.s17s18.37
Polar ICL3 K 387 - S6 V 77 N.S6.07
Hydrophobic ICL3 K 387 - S6 V 77 N.S6.07
Van-der-waals ICL3 K 387 - S6 V 77 N.S6.07