Beta-arrestin-1 - M5 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
M5 84.1
Beta-arrestin-1 81.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 14.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM4 P 144 4x39 s17s18 R 285 C.s17s18.11
Hydrophobic TM5 L 230 5x75 S6 F 75 N.S6.01
Hydrophobic TM5 D 226 5x71 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 P 135 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 135 34x50 S5 Y 63 N.S5.12
Hydrophobic TM5 R 223 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 R 223 5x68 s15s16 F 244 C.s15s16.03
Ionic ICL2 R 142 34x57 s5s6 D 67 N.s5s6.04
Polar ICL2 R 142 34x57 s5s6 D 67 N.s5s6.04
Van-der-waals ICL2 R 142 34x57 s5s6 D 67 N.s5s6.04
Polar C-term W 525 - s20c D 401 C.s20c.11
Hydrophobic C-term W 525 - s20c D 401 C.s20c.11
Van-der-waals C-term W 525 - s20c D 401 C.s20c.11
Hydrophobic TM5 L 227 5x72 S6 F 75 N.S6.01
Van-der-waals TM5 L 227 5x72 S6 F 75 N.S6.01
Polar TM6 K 436 6x29 s5s6 T 74 N.s5s6.11
Hydrophobic TM3 I 132 3x54 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 I 132 3x54 s5s6 L 71 N.s5s6.08
Polar ICL2 R 139 34x54 s5s6 G 64 N.s5s6.01
Hydrophobic TM6 T 443 6x36 s5s6 V 70 N.s5s6.07
Hydrophobic TM2 T 63 2x37 s8s9 E 134 N.s8s9.05
Van-der-waals TM2 T 63 2x37 s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 A 140 34x55 S16 Y 249 C.S16.03
Hydrophobic ICL2 L 136 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 L 136 34x51 s15s16 N 245 C.s15s16.04
Polar TM3 S 131 3x53 s5s6 R 65 N.s5s6.02
Polar ICL1 Q 60 12x49 s20c K 403 C.s20c.13
Van-der-waals ICL1 Q 60 12x49 s20c K 403 C.s20c.13
Polar TM6 K 436 6x29 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 K 436 6x29 s5s6 G 72 N.s5s6.09
Polar TM5 R 223 5x68 S5 Y 63 N.S5.12
Van-der-waals TM5 R 223 5x68 S5 Y 63 N.S5.12
Ionic ICL2 R 139 34x54 s8s9 D 135 N.s8s9.06
Polar ICL2 R 139 34x54 s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 R 139 34x54 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 R 139 34x54 s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 L 136 34x51 S16 A 247 C.S16.01
Polar TM2 Y 67 2x41 s8s9 E 134 N.s8s9.05
Hydrophobic TM2 Y 67 2x41 s8s9 E 134 N.s8s9.05
Van-der-waals TM2 Y 67 2x41 s8s9 E 134 N.s8s9.05
Ionic H8 K 504 8x52 s20c E 405 C.s20c.15
Polar H8 K 504 8x52 s20c E 405 C.s20c.15
Hydrophobic H8 K 504 8x52 s20c E 405 C.s20c.15
Van-der-waals H8 K 504 8x52 s20c E 405 C.s20c.15
Hydrophobic TM4 P 144 4x39 s8s9 E 134 N.s8s9.05
Van-der-waals TM4 P 144 4x39 s8s9 E 134 N.s8s9.05
Ionic ICL2 R 142 34x57 s8s9 D 135 N.s8s9.06
Hydrophobic C-term W 525 - s20c K 403 C.s20c.13
Van-der-waals C-term W 525 - s20c K 403 C.s20c.13
Hydrophobic TM3 I 132 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic TM5 L 227 5x72 S6 R 76 N.S6.02
Polar ICL3 Q 231 - S6 R 76 N.S6.02
Hydrophobic ICL2 L 136 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 L 136 34x51 S15 I 241 C.S15.14
Hydrophobic TM6 A 440 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 T 137 34x52 S16 A 247 C.S16.01
Van-der-waals ICL2 T 137 34x52 S16 A 247 C.S16.01
Polar ICL1 Q 60 12x49 s8s9 T 136 N.s8s9.07
Hydrophobic ICL1 Q 60 12x49 s8s9 T 136 N.s8s9.07
Polar TM3 T 133 3x55 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 T 133 3x55 s15s16 N 245 C.s15s16.04
Polar ICL2 L 136 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 L 136 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 L 136 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 R 142 34x57 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 R 142 34x57 s5s6 R 65 N.s5s6.02
Polar TM2 N 65 2x39 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 N 65 2x39 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 N 65 2x39 s5s6 D 67 N.s5s6.04
Hydrophobic TM7 C 498 7x56 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 C 498 7x56 s5s6 V 70 N.s5s6.07
Ionic H8 R 500 8x48 s20c E 407 C.s20c.17
Polar H8 R 500 8x48 s20c E 407 C.s20c.17
Hydrophobic H8 R 500 8x48 s20c E 407 C.s20c.17
Van-der-waals H8 R 500 8x48 s20c E 407 C.s20c.17
Hydrophobic ICL2 R 139 34x54 s8s9 P 131 N.s8s9.02
Van-der-waals ICL2 R 139 34x54 s8s9 P 131 N.s8s9.02
Polar ICL2 R 139 34x54 s8s9 K 138 N.s8s9.09
Van-der-waals ICL2 R 139 34x54 s8s9 K 138 N.s8s9.09
Hydrophobic TM5 L 230 5x75 S6 K 77 N.S6.03
Van-der-waals TM5 L 230 5x75 S6 K 77 N.S6.03
Ionic C-term E 521 - s20c K 403 C.s20c.13
Polar C-term E 521 - s20c K 403 C.s20c.13
Hydrophobic C-term E 521 - s20c K 403 C.s20c.13
Van-der-waals C-term E 521 - s20c K 403 C.s20c.13
Hydrophobic TM3 S 131 3x53 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 S 131 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic TM6 L 444 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 I 216 5x61 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 A 140 34x55 s17s18 R 285 C.s17s18.11
Polar ICL2 R 139 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 R 139 34x54 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 R 139 34x54 s5s6 R 65 N.s5s6.02
Polar ICL3 K 428 - s9s10 E 155 N.s9s10.07
Van-der-waals ICL3 K 428 - s9s10 E 155 N.s9s10.07
Hydrophobic H8 N 499 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic TM4 T 143 4x38 s17s18 R 285 C.s17s18.11
Hydrophobic C-term W 525 - s20c R 395 C.s20c.05
Van-der-waals C-term W 525 - s20c R 395 C.s20c.05
Hydrophobic TM5 L 230 5x75 s15s16 F 244 C.s15s16.03
Polar TM2 V 64 2x38 s8s9 E 134 N.s8s9.05
Hydrophobic TM2 V 64 2x38 s8s9 E 134 N.s8s9.05
Van-der-waals TM2 V 64 2x38 s8s9 E 134 N.s8s9.05
Polar ICL2 R 139 34x54 s8s9 G 137 N.s8s9.08
Ionic ICL3 R 429 - S6 D 78 N.S6.04
Polar ICL3 R 429 - S6 D 78 N.S6.04
Van-der-waals ICL3 R 429 - S6 D 78 N.S6.04
Hydrophobic TM3 I 132 3x54 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 I 132 3x54 s5s6 L 68 N.s5s6.05
Polar ICL2 R 142 34x57 s17s18 R 285 C.s17s18.11
Van-der-waals ICL2 R 142 34x57 s17s18 R 285 C.s17s18.11
Hydrophobic ICL2 L 136 34x51 S9 C 140 N.S9.01
Van-der-waals ICL2 L 136 34x51 S9 C 140 N.S9.01
Hydrophobic TM5 T 220 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 T 220 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic TM2 T 63 2x37 s8s9 T 136 N.s8s9.07
Van-der-waals TM2 T 63 2x37 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 P 135 34x50 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 P 135 34x50 s15s16 N 245 C.s15s16.04
Polar ICL2 T 137 34x52 S16 Y 249 C.S16.03
Hydrophobic ICL2 T 137 34x52 S16 Y 249 C.S16.03
Polar ICL2 R 139 34x54 s8s9 T 136 N.s8s9.07
Hydrophobic ICL1 Q 60 12x49 s20c E 405 C.s20c.15
Van-der-waals ICL1 Q 60 12x49 s20c E 405 C.s20c.15