Arrestin-C - M5 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
M5 82.6
Arrestin-C 81.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 I 216 5x61 s5s6 I 67 N.s5s6.08
Polar H8 R 500 8x48 s20c G 387 C.s20c.21
Hydrophobic H8 R 500 8x48 s20c G 387 C.s20c.21
Van-der-waals H8 R 500 8x48 s20c G 387 C.s20c.21
Polar ICL3 Q 231 - S6 D 74 N.S6.04
Hydrophobic ICL2 L 136 34x51 S16 Y 246 C.S16.03
Van-der-waals ICL2 L 136 34x51 S16 Y 246 C.S16.03
Hydrophobic ICL3 V 236 - S6 V 77 N.S6.07
Van-der-waals ICL3 V 236 - S6 V 77 N.S6.07
Hydrophobic TM3 I 132 3x54 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 I 132 3x54 s5s6 L 64 N.s5s6.05
Polar ICL2 T 137 34x52 S16 D 244 C.S16.01
Hydrophobic ICL2 T 137 34x52 S16 D 244 C.S16.01
Van-der-waals ICL2 T 137 34x52 S16 D 244 C.S16.01
Hydrophobic ICL3 Q 425 - S5 M 52 N.S5.05
Van-der-waals ICL3 Q 425 - S5 M 52 N.S5.05
Polar H8 N 499 8x47 s5s6 D 62 N.s5s6.03
Polar ICL2 P 135 34x50 S5 Y 59 N.S5.12
Hydrophobic ICL2 P 135 34x50 S5 Y 59 N.S5.12
Van-der-waals ICL2 P 135 34x50 S5 Y 59 N.S5.12
Polar ICL2 R 139 34x54 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 R 139 34x54 s8s9 A 133 N.s8s9.07
Hydrophobic TM3 R 128 3x50 s5s6 I 67 N.s5s6.08
Polar ICL2 R 139 34x54 s17s18 R 282 C.s17s18.11
Hydrophobic ICL2 R 139 34x54 s17s18 R 282 C.s17s18.11
Van-der-waals ICL2 R 139 34x54 s17s18 R 282 C.s17s18.11
Hydrophobic ICL2 L 136 34x51 S9 C 137 N.S9.01
Hydrophobic TM5 L 230 5x75 s17s18 D 308 C.s17s18.37
Van-der-waals TM5 L 230 5x75 s17s18 D 308 C.s17s18.37
Hydrophobic TM3 I 132 3x54 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 P 135 34x50 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 P 135 34x50 s15s16 S 242 C.s15s16.04
Ionic H8 K 504 8x52 s20c E 386 C.s20c.20
Polar H8 K 504 8x52 s20c E 386 C.s20c.20
Van-der-waals H8 K 504 8x52 s20c E 386 C.s20c.20
Hydrophobic TM5 L 230 5x75 S6 K 73 N.S6.03
Van-der-waals TM5 L 230 5x75 S6 K 73 N.S6.03
Ionic ICL2 R 139 34x54 s5s6 D 63 N.s5s6.04
Polar ICL1 Q 60 12x49 s20c E 383 C.s20c.17
Hydrophobic ICL1 Q 60 12x49 s20c E 383 C.s20c.17
Van-der-waals ICL1 Q 60 12x49 s20c E 383 C.s20c.17
Ionic C-term K 517 - s20c E 386 C.s20c.20
Polar C-term K 517 - s20c E 386 C.s20c.20
Hydrophobic C-term K 517 - s20c E 386 C.s20c.20
Van-der-waals C-term K 517 - s20c E 386 C.s20c.20
Hydrophobic TM2 T 63 2x37 s8s9 A 133 N.s8s9.07
Polar ICL3 Q 425 - S6 T 79 N.S6.09
Hydrophobic ICL3 Q 425 - S6 T 79 N.S6.09
Van-der-waals ICL3 Q 425 - S6 T 79 N.S6.09
Polar ICL2 L 136 34x51 S5 Y 59 N.S5.12
Hydrophobic ICL2 L 136 34x51 S5 Y 59 N.S5.12
Van-der-waals ICL2 L 136 34x51 S5 Y 59 N.S5.12
Hydrophobic TM7 C 498 7x56 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 C 498 7x56 s5s6 V 66 N.s5s6.07
Hydrophobic ICL3 M 426 - S6 D 74 N.S6.04
Polar TM2 N 65 2x39 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 N 65 2x39 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 N 65 2x39 s5s6 D 63 N.s5s6.04
Polar TM6 K 436 6x29 s5s6 T 70 N.s5s6.11
Hydrophobic TM3 T 133 3x55 s15s16 S 242 C.s15s16.04
Van-der-waals TM3 T 133 3x55 s15s16 S 242 C.s15s16.04
Ionic ICL3 K 428 - s9s10 E 152 N.s9s10.07
Polar ICL3 K 428 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL3 K 428 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 K 428 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL2 L 136 34x51 S8 L 126 N.S8.03
Van-der-waals ICL2 L 136 34x51 S8 L 126 N.S8.03
Hydrophobic TM2 N 65 2x39 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 N 65 2x39 s5s6 V 66 N.s5s6.07
Ionic ICL2 R 139 34x54 s8s9 D 132 N.s8s9.06
Polar ICL2 R 139 34x54 s8s9 D 132 N.s8s9.06
Hydrophobic ICL2 R 139 34x54 s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 R 139 34x54 s8s9 D 132 N.s8s9.06
Hydrophobic TM6 L 444 6x37 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 L 444 6x37 s5s6 I 67 N.s5s6.08
Hydrophobic ICL3 V 236 - S6 Y 76 N.S6.06
Polar ICL3 Q 425 - s9s10 P 151 N.s9s10.03
Hydrophobic ICL3 Q 425 - s9s10 P 151 N.s9s10.03
Van-der-waals ICL3 Q 425 - s9s10 P 151 N.s9s10.03
Hydrophobic TM6 A 440 6x33 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 A 440 6x33 s5s6 L 69 N.s5s6.10
Polar ICL2 L 136 34x51 S16 D 244 C.S16.01
Hydrophobic ICL2 L 136 34x51 S16 D 244 C.S16.01
Van-der-waals ICL2 L 136 34x51 S16 D 244 C.S16.01
Polar ICL2 A 140 34x55 s17s18 R 282 C.s17s18.11
Hydrophobic ICL2 A 140 34x55 s17s18 R 282 C.s17s18.11
Van-der-waals ICL2 A 140 34x55 s17s18 R 282 C.s17s18.11
Hydrophobic TM6 E 437 6x30 s5s6 L 69 N.s5s6.10
Hydrophobic TM5 R 223 5x68 S6 F 71 N.S6.01
Van-der-waals TM5 R 223 5x68 S6 F 71 N.S6.01
Ionic ICL3 R 429 - S6 D 74 N.S6.04
Polar ICL3 R 429 - S6 D 74 N.S6.04
Van-der-waals ICL3 R 429 - S6 D 74 N.S6.04
Hydrophobic TM4 P 144 4x39 s8s9 E 131 N.s8s9.05
Van-der-waals TM4 P 144 4x39 s8s9 E 131 N.s8s9.05
Polar ICL3 Q 425 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL3 Q 425 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 Q 425 - s9s10 E 152 N.s9s10.07
Polar TM3 R 128 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 R 128 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 128 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic C-term W 525 - s20c K 378 C.s20c.11
Van-der-waals C-term W 525 - s20c K 378 C.s20c.11
Hydrophobic ICL2 T 137 34x52 S16 K 245 C.S16.02
Van-der-waals ICL2 T 137 34x52 S16 K 245 C.S16.02
Polar ICL2 P 135 34x50 S16 D 244 C.S16.01
Hydrophobic ICL2 P 135 34x50 S16 D 244 C.S16.01
Hydrophobic ICL2 T 137 34x52 S16 Y 246 C.S16.03
Hydrophobic TM5 T 220 5x65 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 T 220 5x65 s5s6 L 69 N.s5s6.10
Polar TM5 R 223 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 R 223 5x68 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 R 223 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 L 230 5x75 s17s18 E 310 C.s17s18.39
Hydrophobic ICL3 R 429 - S5 M 52 N.S5.05
Van-der-waals ICL3 R 429 - S5 M 52 N.S5.05
Hydrophobic TM3 R 134 3x56 S16 D 244 C.S16.01
Van-der-waals TM3 R 134 3x56 S16 D 244 C.S16.01
Hydrophobic TM5 L 230 5x75 s17s18 L 311 C.s17s18.40
Van-der-waals TM5 L 230 5x75 s17s18 L 311 C.s17s18.40
Hydrophobic TM6 A 440 6x33 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 A 440 6x33 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 S 131 3x53 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 S 131 3x53 s5s6 L 64 N.s5s6.05
Ionic ICL2 R 142 34x57 s5s6 D 63 N.s5s6.04
Polar ICL2 R 142 34x57 s5s6 D 63 N.s5s6.04
Van-der-waals ICL2 R 142 34x57 s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 L 136 34x51 S15 V 238 C.S15.14
Van-der-waals ICL2 L 136 34x51 S15 V 238 C.S15.14
Polar ICL3 R 429 - S5 T 54 N.S5.07
Van-der-waals TM5 E 219 5x64 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 L 227 5x72 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 L 227 5x72 S6 K 73 N.S6.03
Van-der-waals TM5 L 227 5x72 S6 K 73 N.S6.03
Polar TM5 D 226 5x71 S6 K 73 N.S6.03
Hydrophobic ICL3 M 426 - S6 V 77 N.S6.07
Hydrophobic TM3 I 132 3x54 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 I 132 3x54 s5s6 I 67 N.s5s6.08