ArrestinDb

S-arrestin - M₅ receptor complex model

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Tertiary structure confidence

Chain	pLDDT score avg
M₅	83.3
S-arrestin	82.5

Very high (>90)

Confident (90-70)

Low (70-50)

Very low (<50)

Disordered

PTM Score: 0.7

iPTM Score: 0.6

PAE mean: 15.8

GPCR - Arrestin interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Aromatic	ICL3	R	429	-	S6	F	89	N.S6.07
Aromatic	C-term	Y	524	-	s1s2	R	22	N.s1s2.02
Hydrophobic	ICL2	L	136	34x51	S9	C	147	N.S9.01
Hydrophobic	H8	K	504	8x52	s20c	E	405	C.s20c.24
Hydrophobic	ICL2	R	139	34x54	s5s6	Q	73	N.s5s6.02
Hydrophobic	TM5	R	223	5x68	S6	R	85	N.S6.03
Hydrophobic	TM3	R	128	3x50	s5s6	V	78	N.s5s6.07
Hydrophobic	ICL3	K	428	-	s9s10	D	162	N.s9s10.04
Hydrophobic	TM5	R	223	5x68	s15s16	Y	254	C.s15s16.03
Hydrophobic	ICL2	T	137	34x52	S16	D	257	C.S16.01
Hydrophobic	TM5	L	227	5x72	S6	R	85	N.S6.03
Hydrophobic	TM6	L	444	6x37	s5s6	I	79	N.s5s6.08
Hydrophobic	ICL2	T	137	34x52	S16	Y	259	C.S16.03
Hydrophobic	ICL2	R	139	34x54	s5s6	I	76	N.s5s6.05
Hydrophobic	ICL3	R	429	-	S6	F	89	N.S6.07
Hydrophobic	TM6	E	437	6x30	s5s6	L	81	N.s5s6.10
Hydrophobic	ICL2	L	136	34x51	S5	Y	71	N.S5.12
Hydrophobic	TM5	L	230	5x75	s15s16	L	253	C.s15s16.02
Hydrophobic	TM5	L	230	5x75	s17s18	T	323	C.s17s18.39
Hydrophobic	ICL3	M	426	-	S6	Y	88	N.S6.06
Hydrophobic	ICL2	A	140	34x55	s8s9	D	142	N.s8s9.06
Hydrophobic	TM3	I	132	3x54	s5s6	I	79	N.s5s6.08
Hydrophobic	ICL2	R	139	34x54	s8s9	K	145	N.s8s9.09
Hydrophobic	TM3	I	132	3x54	s5s6	L	81	N.s5s6.10
Hydrophobic	ICL3	Q	425	-	S6	F	89	N.S6.07
Hydrophobic	ICL3	M	426	-	S6	F	89	N.S6.07
Hydrophobic	ICL3	R	429	-	s9s10	E	165	N.s9s10.07
Hydrophobic	TM3	R	128	3x50	s5s6	I	79	N.s5s6.08
Hydrophobic	ICL2	R	139	34x54	s8s9	G	144	N.s8s9.08
Hydrophobic	TM5	I	216	5x61	s5s6	I	79	N.s5s6.08
Hydrophobic	TM5	L	230	5x75	s17s18	V	324	C.s17s18.40
Hydrophobic	ICL2	L	136	34x51	s8s9	K	145	N.s8s9.09
Hydrophobic	H8	N	499	8x47	s5s6	D	77	N.s5s6.06
Hydrophobic	C-term	Y	524	-	s1s2	R	22	N.s1s2.02
Hydrophobic	ICL2	L	136	34x51	S8	L	136	N.S8.03
Hydrophobic	ICL2	L	136	34x51	S16	Y	259	C.S16.03
Hydrophobic	ICL2	P	135	34x50	S6	F	83	N.S6.01
Hydrophobic	C-term	W	525	-	s20c	K	400	C.s20c.19
Hydrophobic	ICL3	M	426	-	S6	L	87	N.S6.05
Hydrophobic	ICL2	A	140	34x55	s8s9	K	145	N.s8s9.09
Hydrophobic	TM3	S	131	3x53	S6	F	83	N.S6.01
Hydrophobic	TM5	T	220	5x65	s5s6	L	81	N.s5s6.10
Hydrophobic	TM3	I	132	3x54	S6	F	83	N.S6.01
Hydrophobic	ICL2	P	135	34x50	S5	Y	71	N.S5.12
Hydrophobic	TM6	A	440	6x33	s5s6	L	81	N.s5s6.10
Hydrophobic	ICL2	L	136	34x51	S15	V	251	C.S15.14
Hydrophobic	TM6	T	443	6x36	s5s6	I	79	N.s5s6.08
Hydrophobic	ICL3	Q	425	-	S6	R	91	N.S6.09
Ionic	H8	K	504	8x52	s20c	E	405	C.s20c.24
Ionic	ICL3	K	428	-	s9s10	D	162	N.s9s10.04
Ionic	TM6	K	436	6x29	s9s10	D	166	N.s9s10.08
Ionic	ICL3	R	429	-	s9s10	E	165	N.s9s10.07
Ionic	H8	R	500	8x48	s9s10	D	166	N.s9s10.08
Ionic	C-term	K	517	-	s20c	E	405	C.s20c.24
Ionic	ICL3	R	429	-	S6	D	86	N.S6.04
Polar	H8	K	504	8x52	s20c	E	405	C.s20c.24
Polar	ICL2	R	139	34x54	s5s6	Q	73	N.s5s6.02
Polar	TM5	R	223	5x68	S6	R	85	N.S6.03
Polar	TM3	R	128	3x50	s5s6	V	78	N.s5s6.07
Polar	ICL3	K	428	-	s9s10	D	162	N.s9s10.04
Polar	TM6	K	436	6x29	s9s10	D	166	N.s9s10.08
Polar	ICL2	T	137	34x52	S16	Y	259	C.S16.03
Polar	ICL2	L	136	34x51	S5	Y	71	N.S5.12
Polar	ICL3	S	423	-	S6	F	89	N.S6.07
Polar	ICL2	R	139	34x54	s8s9	K	145	N.s8s9.09
Polar	ICL3	Q	231	-	S6	D	86	N.S6.04
Polar	ICL3	R	429	-	s9s10	E	165	N.s9s10.07
Polar	H8	R	500	8x48	s5s6	D	77	N.s5s6.06
Polar	ICL2	R	139	34x54	s8s9	G	144	N.s8s9.08
Polar	H8	N	499	8x47	s5s6	D	77	N.s5s6.06
Polar	C-term	Y	524	-	s1s2	R	22	N.s1s2.02
Polar	H8	R	500	8x48	s9s10	D	166	N.s9s10.08
Polar	C-term	K	517	-	s20c	E	405	C.s20c.24
Polar	ICL3	R	429	-	S5	T	66	N.S5.07
Polar	ICL3	R	429	-	S6	D	86	N.S6.04
Polar	ICL2	P	135	34x50	S5	Y	71	N.S5.12
Van-der-waals	ICL2	L	136	34x51	S9	C	147	N.S9.01
Van-der-waals	H8	K	504	8x52	s20c	E	405	C.s20c.24
Van-der-waals	ICL2	R	139	34x54	s5s6	Q	73	N.s5s6.02
Van-der-waals	TM5	R	223	5x68	S6	R	85	N.S6.03
Van-der-waals	TM3	R	128	3x50	s5s6	V	78	N.s5s6.07
Van-der-waals	ICL3	K	428	-	s9s10	D	162	N.s9s10.04
Van-der-waals	TM5	R	223	5x68	s15s16	Y	254	C.s15s16.03
Van-der-waals	TM5	L	227	5x72	S6	R	85	N.S6.03
Van-der-waals	TM6	L	444	6x37	s5s6	I	79	N.s5s6.08
Van-der-waals	TM6	K	436	6x29	s9s10	D	166	N.s9s10.08
Van-der-waals	ICL2	T	137	34x52	S16	Y	259	C.S16.03
Van-der-waals	ICL2	R	139	34x54	s5s6	I	76	N.s5s6.05
Van-der-waals	ICL3	R	429	-	S6	F	89	N.S6.07
Van-der-waals	ICL2	L	136	34x51	S5	Y	71	N.S5.12
Van-der-waals	TM5	L	230	5x75	s15s16	L	253	C.s15s16.02
Van-der-waals	TM5	L	230	5x75	s17s18	T	323	C.s17s18.39
Van-der-waals	TM6	A	440	6x33	s5s6	I	79	N.s5s6.08
Van-der-waals	TM3	I	132	3x54	s5s6	I	79	N.s5s6.08
Van-der-waals	ICL2	R	139	34x54	s8s9	K	145	N.s8s9.09
Van-der-waals	ICL3	Q	231	-	S6	D	86	N.S6.04
Van-der-waals	TM5	L	230	5x75	S6	R	85	N.S6.03
Van-der-waals	ICL3	Q	425	-	S6	F	89	N.S6.07
Van-der-waals	ICL3	R	429	-	s9s10	E	165	N.s9s10.07
Van-der-waals	H8	R	500	8x48	s5s6	D	77	N.s5s6.06
Van-der-waals	ICL2	R	139	34x54	s8s9	G	144	N.s8s9.08
Van-der-waals	TM5	L	230	5x75	s17s18	V	324	C.s17s18.40
Van-der-waals	ICL2	L	136	34x51	s8s9	K	145	N.s8s9.09
Van-der-waals	H8	N	499	8x47	s5s6	D	77	N.s5s6.06
Van-der-waals	TM5	R	223	5x68	S6	F	83	N.S6.01
Van-der-waals	C-term	Y	524	-	s1s2	R	22	N.s1s2.02
Van-der-waals	ICL2	L	136	34x51	S8	L	136	N.S8.03
Van-der-waals	ICL2	L	136	34x51	S16	Y	259	C.S16.03
Van-der-waals	H8	R	500	8x48	s9s10	D	166	N.s9s10.08
Van-der-waals	C-term	W	525	-	s20c	K	400	C.s20c.19
Van-der-waals	ICL3	M	426	-	S6	L	87	N.S6.05
Van-der-waals	ICL2	A	140	34x55	s8s9	K	145	N.s8s9.09
Van-der-waals	TM3	S	131	3x53	S6	F	83	N.S6.01
Van-der-waals	C-term	K	517	-	s20c	E	405	C.s20c.24
Van-der-waals	ICL3	R	429	-	S6	D	86	N.S6.04
Van-der-waals	ICL2	P	135	34x50	S5	Y	71	N.S5.12
Van-der-waals	TM6	A	440	6x33	s5s6	L	81	N.s5s6.10
Van-der-waals	ICL2	L	136	34x51	S15	V	251	C.S15.14
Van-der-waals	ICL3	Q	425	-	S6	R	91	N.S6.09

Showing 1 to 119 of 119 entries

Join us

Cite us

Main reference

S-arrestin - M5 receptor complex model Download Full