Arrestin-C - MC2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
MC2 80.0
Arrestin-C 80.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 17.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 R 128 3x50 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 R 128 3x50 s5s6 L 64 N.s5s6.05
Hydrophobic TM5 I 207 5x72 S6 L 75 N.S6.05
Hydrophobic TM5 K 206 5x71 s17s18 L 311 C.s17s18.40
Van-der-waals TM5 K 206 5x71 s17s18 L 311 C.s17s18.40
Hydrophobic TM5 I 207 5x72 S6 K 73 N.S6.03
Van-der-waals TM5 I 207 5x72 S6 K 73 N.S6.03
Hydrophobic TM5 I 207 5x72 S6 D 74 N.S6.04
Van-der-waals TM5 I 207 5x72 S6 D 74 N.S6.04
Polar TM6 T 220 6x36 s5s6 G 68 N.s5s6.09
Hydrophobic TM6 T 220 6x36 s5s6 G 68 N.s5s6.09
Polar TM3 R 128 3x50 s5s6 D 63 N.s5s6.04
Ionic ICL2 H 139 34x54 s8s9 D 132 N.s8s9.06
Polar ICL2 H 139 34x54 s8s9 D 132 N.s8s9.06
Hydrophobic ICL2 H 139 34x54 s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 H 139 34x54 s8s9 D 132 N.s8s9.06
Ionic H8 K 289 8x56 s20c E 383 C.s20c.17
Ionic TM3 H 134 3x56 S16 D 244 C.S16.01
Polar TM3 H 134 3x56 S16 D 244 C.S16.01
Polar TM7 R 279 7x56 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 R 279 7x56 s5s6 V 66 N.s5s6.07
Ionic TM5 K 206 5x71 s17s18 E 310 C.s17s18.39
Polar TM5 K 206 5x71 s17s18 E 310 C.s17s18.39
Hydrophobic TM5 K 206 5x71 s17s18 E 310 C.s17s18.39
Van-der-waals TM5 K 206 5x71 s17s18 E 310 C.s17s18.39
Hydrophobic ICL2 H 139 34x54 s5s6 R 61 N.s5s6.02
Polar TM3 I 132 3x54 S5 Y 59 N.S5.12
Hydrophobic TM3 I 132 3x54 S5 Y 59 N.S5.12
Van-der-waals TM3 I 132 3x54 S5 Y 59 N.S5.12
Polar ICL2 L 136 34x51 S16 Y 246 C.S16.03
Hydrophobic ICL2 L 136 34x51 S16 Y 246 C.S16.03
Van-der-waals ICL2 L 136 34x51 S16 Y 246 C.S16.03
Ionic ICL2 R 137 34x52 S16 D 244 C.S16.01
Polar ICL2 R 137 34x52 S16 D 244 C.S16.01
Hydrophobic ICL2 R 137 34x52 S16 D 244 C.S16.01
Van-der-waals ICL2 R 137 34x52 S16 D 244 C.S16.01
Hydrophobic TM5 L 199 5x64 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 L 199 5x64 s15s16 Y 241 C.s15s16.03
Hydrophobic TM3 T 131 3x53 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 T 131 3x53 s5s6 L 64 N.s5s6.05
Hydrophobic TM5 M 196 5x61 s5s6 I 67 N.s5s6.08
Van-der-waals TM5 M 196 5x61 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 H 203 5x68 S6 K 73 N.S6.03
Ionic ICL3 R 212 - s9s10 E 152 N.s9s10.07
Polar ICL3 R 212 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL3 R 212 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 R 212 - s9s10 E 152 N.s9s10.07
Van-der-waals TM6 G 217 6x33 s5s6 I 67 N.s5s6.08
Hydrophobic TM2 M 59 2x39 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 M 59 2x39 s5s6 D 63 N.s5s6.04
Hydrophobic TM5 Y 193 5x58 s5s6 I 67 N.s5s6.08
Polar TM5 H 203 5x68 s15s16 Y 241 C.s15s16.03
Aromatic TM5 H 203 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 H 203 5x68 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 H 203 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 L 136 34x51 S15 V 238 C.S15.14
Van-der-waals ICL2 L 136 34x51 S15 V 238 C.S15.14
Hydrophobic TM6 G 217 6x33 s5s6 L 69 N.s5s6.10
Polar TM3 T 131 3x53 S5 Y 59 N.S5.12
Hydrophobic TM3 T 131 3x53 S5 Y 59 N.S5.12
Van-der-waals TM3 T 131 3x53 S5 Y 59 N.S5.12
Polar TM3 H 134 3x56 S5 Y 59 N.S5.12
Polar ICL2 H 139 34x54 s8s9 E 131 N.s8s9.05
Hydrophobic ICL2 H 139 34x54 s8s9 E 131 N.s8s9.05
Hydrophobic TM6 T 220 6x36 s5s6 V 66 N.s5s6.07
Van-der-waals TM6 T 220 6x36 s5s6 V 66 N.s5s6.07
Polar ICL2 A 135 34x50 S5 Y 59 N.S5.12
Hydrophobic ICL2 A 135 34x50 S5 Y 59 N.S5.12
Van-der-waals ICL2 A 135 34x50 S5 Y 59 N.S5.12
Hydrophobic H8 E 282 8x49 s5s6 D 63 N.s5s6.04
Van-der-waals H8 E 282 8x49 s5s6 D 63 N.s5s6.04
Hydrophobic TM3 R 128 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 128 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic TM5 A 200 5x65 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 A 200 5x65 s5s6 L 69 N.s5s6.10
Hydrophobic TM5 H 203 5x68 s15s16 L 240 C.s15s16.02
Hydrophobic TM5 A 200 5x65 s15s16 Y 241 C.s15s16.03
Hydrophobic TM3 R 128 3x50 s5s6 I 67 N.s5s6.08
Polar ICL2 R 137 34x52 S16 K 245 C.S16.02
Van-der-waals ICL2 R 137 34x52 S16 K 245 C.S16.02
Hydrophobic TM7 Y 276 7x53 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 L 136 34x51 S9 C 137 N.S9.01
Polar ICL2 R 137 34x52 S16 Y 246 C.S16.03
Aromatic ICL2 R 137 34x52 S16 Y 246 C.S16.03
Hydrophobic ICL2 R 137 34x52 S16 Y 246 C.S16.03
Van-der-waals ICL2 R 137 34x52 S16 Y 246 C.S16.03
Hydrophobic TM3 I 132 3x54 S6 F 71 N.S6.01
Van-der-waals TM3 I 132 3x54 S6 F 71 N.S6.01
Polar TM6 T 220 6x36 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 T 220 6x36 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 T 220 6x36 s5s6 I 67 N.s5s6.08
Polar TM3 F 133 3x55 s15s16 S 242 C.s15s16.04
Hydrophobic TM3 F 133 3x55 s15s16 S 242 C.s15s16.04
Van-der-waals TM3 F 133 3x55 s15s16 S 242 C.s15s16.04
Hydrophobic TM3 I 132 3x54 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 L 136 34x51 S8 L 126 N.S8.03
Van-der-waals ICL2 L 136 34x51 S8 L 126 N.S8.03