Beta-arrestin-1 - α1A-adrenoceptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
α1A 63.4
Beta-arrestin-1 78.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar C-term S 458 - S11 R 188 C.S11.05
Hydrophobic C-term C 395 - S16 P 252 C.S16.06
Polar TM6 R 266 6x29 s5s6 T 74 N.s5s6.11
Hydrophobic TM6 R 266 6x29 s5s6 T 74 N.s5s6.11
Van-der-waals TM6 R 266 6x29 s5s6 T 74 N.s5s6.11
Hydrophobic TM3 G 127 3x53 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 G 127 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic TM6 A 270 6x33 s5s6 G 72 N.s5s6.09
Hydrophobic TM3 R 124 3x50 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 R 124 3x50 s5s6 L 68 N.s5s6.05
Polar TM4 Q 140 4x39 s8s9 E 134 N.s8s9.05
Van-der-waals TM4 Q 140 4x39 s8s9 E 134 N.s8s9.05
Hydrophobic TM3 R 124 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 R 124 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic C-term F 399 - S16 A 247 C.S16.01
Hydrophobic TM6 A 270 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 A 270 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 V 128 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 V 128 3x54 s5s6 L 73 N.s5s6.10
Aromatic C-term W 397 - S16 Y 249 C.S16.03
Hydrophobic C-term W 397 - S16 Y 249 C.S16.03
Van-der-waals C-term W 397 - S16 Y 249 C.S16.03
Ionic ICL1 H 56 12x49 s20c E 404 C.s20c.14
Polar ICL1 H 56 12x49 s20c E 404 C.s20c.14
Hydrophobic ICL1 H 56 12x49 s20c E 404 C.s20c.14
Van-der-waals ICL1 H 56 12x49 s20c E 404 C.s20c.14
Ionic TM6 K 263 6x26 S6 D 78 N.S6.04
Polar TM6 K 263 6x26 S6 D 78 N.S6.04
Hydrophobic TM6 K 263 6x26 S6 D 78 N.S6.04
Van-der-waals TM6 K 263 6x26 S6 D 78 N.S6.04
Ionic H8 K 335 8x52 s20c E 407 C.s20c.17
Polar H8 K 335 8x52 s20c E 407 C.s20c.17
Van-der-waals H8 K 335 8x52 s20c E 407 C.s20c.17
Hydrophobic TM3 V 128 3x54 s5s6 L 68 N.s5s6.05
Hydrophobic TM5 L 218 5x72 S6 K 77 N.S6.03
Van-der-waals TM5 L 218 5x72 S6 K 77 N.S6.03
Hydrophobic TM6 K 269 6x32 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 R 266 6x29 S6 R 76 N.S6.02
Hydrophobic ICL2 L 132 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 L 132 34x51 S15 I 241 C.S15.14
Hydrophobic TM2 H 62 2x40 s5s6 D 67 N.s5s6.04
Polar ICL2 L 132 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 L 132 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 L 132 34x51 S16 Y 249 C.S16.03
Hydrophobic TM6 T 273 6x36 s5s6 V 70 N.s5s6.07
Van-der-waals TM6 T 273 6x36 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 L 132 34x51 S8 L 129 N.S8.03
Hydrophobic H8 E 332 8x49 s5s6 E 66 N.s5s6.03
Van-der-waals H8 E 332 8x49 s5s6 E 66 N.s5s6.03
Hydrophobic TM6 T 273 6x36 s5s6 L 71 N.s5s6.08
Polar TM2 T 61 2x39 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 T 61 2x39 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 T 61 2x39 s5s6 D 67 N.s5s6.04
Hydrophobic TM6 A 270 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 270 6x33 s5s6 L 73 N.s5s6.10
Polar TM7 S 329 7x56 s5s6 V 70 N.s5s6.07
Hydrophobic TM7 S 329 7x56 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 S 329 7x56 s5s6 V 70 N.s5s6.07
Ionic TM6 K 269 6x32 s5s6 D 69 N.s5s6.06
Polar TM6 K 269 6x32 s5s6 D 69 N.s5s6.06
Polar C-term C 395 - s17s18 R 285 C.s17s18.11
Hydrophobic ICL2 L 132 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 L 132 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic TM5 V 207 5x61 s5s6 L 73 N.s5s6.10
Hydrophobic ICL3 V 259 - S6 D 78 N.S6.04
Polar C-term C 395 - S16 C 251 C.S16.05
Hydrophobic C-term C 395 - S16 C 251 C.S16.05
Van-der-waals C-term C 395 - S16 C 251 C.S16.05
Hydrophobic TM5 A 211 5x65 s5s6 L 73 N.s5s6.10
Polar ICL2 R 133 34x52 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 R 133 34x52 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 R 133 34x52 s15s16 N 245 C.s15s16.04
Polar ICL1 H 56 12x49 s8s9 T 136 N.s8s9.07
Hydrophobic ICL1 H 56 12x49 s8s9 T 136 N.s8s9.07
Van-der-waals ICL1 H 56 12x49 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 L 132 34x51 S16 A 247 C.S16.01
Hydrophobic TM5 E 214 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 E 214 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 L 132 34x51 S9 C 140 N.S9.01
Hydrophobic ICL2 P 131 34x50 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 V 128 3x54 S6 F 75 N.S6.01
Hydrophobic TM5 V 207 5x61 s5s6 L 71 N.s5s6.08
Ionic C-term H 455 - S11 E 185 C.S11.02
Polar C-term H 455 - S11 E 185 C.S11.02
Van-der-waals C-term H 455 - S11 E 185 C.S11.02
Hydrophobic ICL3 F 257 - s9s10 E 155 N.s9s10.07
Van-der-waals ICL3 F 257 - s9s10 E 155 N.s9s10.07
Hydrophobic ICL3 T 255 - S6 N 83 N.S6.09
Van-der-waals ICL3 T 255 - S6 N 83 N.S6.09
Hydrophobic TM5 G 221 5x75 S6 K 77 N.S6.03
Hydrophobic TM7 Y 326 7x53 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 Y 326 7x53 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 Y 134 34x53 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 Y 134 34x53 s5s6 R 65 N.s5s6.02
Polar ICL2 L 132 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 L 132 34x51 S5 Y 63 N.S5.12
Van-der-waals ICL2 L 132 34x51 S5 Y 63 N.S5.12
Hydrophobic TM5 L 218 5x72 s15s16 F 244 C.s15s16.03
Polar ICL2 P 131 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 P 131 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 131 34x50 S5 Y 63 N.S5.12
Polar TM5 G 217 5x71 S6 K 77 N.S6.03
Hydrophobic ICL2 P 135 34x54 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 P 135 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic TM5 E 214 5x68 S6 F 75 N.S6.01
Hydrophobic ICL3 V 259 - S6 V 81 N.S6.07
Van-der-waals ICL3 V 259 - S6 V 81 N.S6.07
Hydrophobic ICL2 P 135 34x54 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 P 135 34x54 s8s9 D 135 N.s8s9.06
Hydrophobic TM3 Y 130 3x56 s15s16 N 245 C.s15s16.04
Polar C-term C 395 - S16 K 250 C.S16.04
Hydrophobic C-term C 395 - S16 K 250 C.S16.04
Van-der-waals C-term C 395 - S16 K 250 C.S16.04
Hydrophobic TM6 L 274 6x37 s5s6 L 71 N.s5s6.08
Ionic TM3 R 124 3x50 s5s6 D 67 N.s5s6.04
Polar TM3 R 124 3x50 s5s6 D 67 N.s5s6.04
Hydrophobic TM3 R 124 3x50 s5s6 D 67 N.s5s6.04
Van-der-waals TM3 R 124 3x50 s5s6 D 67 N.s5s6.04
Hydrophobic H8 S 330 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic H8 S 330 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic TM5 L 218 5x72 S6 R 76 N.S6.02
Van-der-waals TM5 L 218 5x72 S6 R 76 N.S6.02
Hydrophobic TM3 V 128 3x54 s5s6 L 71 N.s5s6.08