Beta-arrestin-2 - α1B-adrenoceptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
α1B 59.8
Beta-arrestin-2 79.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM5 N 236 5x71 S6 K 78 N.S6.03
Van-der-waals TM5 N 236 5x71 S6 K 78 N.S6.03
Hydrophobic TM3 V 147 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 V 147 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic ICL1 H 75 12x49 s8s9 T 137 N.s8s9.07
Van-der-waals ICL1 H 75 12x49 s8s9 T 137 N.s8s9.07
Hydrophobic TM5 L 237 5x72 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 L 237 5x72 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 Y 223 5x58 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 T 233 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 T 233 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 L 237 5x72 S6 K 78 N.S6.03
Van-der-waals TM5 L 237 5x72 S6 K 78 N.S6.03
Polar TM2 T 80 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 T 80 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 T 80 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic H8 E 354 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic C-term V 439 - S16 K 251 C.S16.04
Hydrophobic TM3 V 147 3x54 S6 F 76 N.S6.01
Hydrophobic C-term L 441 - S16 Y 250 C.S16.03
Hydrophobic C-term F 444 - S16 Q 249 C.S16.02
Van-der-waals C-term F 444 - S16 Q 249 C.S16.02
Hydrophobic TM3 V 147 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 V 147 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic H8 S 352 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 L 237 5x72 S6 R 77 N.S6.02
Van-der-waals TM5 L 237 5x72 S6 R 77 N.S6.02
Polar ICL3 M 242 - S6 L 80 N.S6.05
Van-der-waals ICL3 M 242 - S6 L 80 N.S6.05
Ionic TM3 R 143 3x50 s5s6 D 68 N.s5s6.04
Polar TM3 R 143 3x50 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 R 143 3x50 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 R 143 3x50 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 R 143 3x50 s5s6 L 69 N.s5s6.05
Polar ICL2 Y 153 34x53 s5s6 R 66 N.s5s6.02
Aromatic ICL2 Y 153 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 Y 153 34x53 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 Y 153 34x53 s5s6 R 66 N.s5s6.02
Polar TM6 R 288 6x29 S6 R 77 N.S6.02
Hydrophobic TM6 R 288 6x29 S6 R 77 N.S6.02
Van-der-waals TM6 R 288 6x29 S6 R 77 N.S6.02
Hydrophobic TM6 K 291 6x32 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 K 291 6x32 s5s6 G 73 N.s5s6.09
Ionic H8 K 353 8x48 s5s6 E 67 N.s5s6.03
Polar H8 K 353 8x48 s5s6 E 67 N.s5s6.03
Hydrophobic H8 K 353 8x48 s5s6 E 67 N.s5s6.03
Van-der-waals H8 K 353 8x48 s5s6 E 67 N.s5s6.03
Polar H8 E 354 8x49 s8s9 T 137 N.s8s9.07
Hydrophobic H8 E 354 8x49 s8s9 T 137 N.s8s9.07
Van-der-waals H8 E 354 8x49 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 L 151 34x51 S16 A 248 C.S16.01
Van-der-waals ICL3 V 241 - S6 D 79 N.S6.04
Van-der-waals TM3 R 143 3x50 s5s6 R 66 N.s5s6.02
Polar TM2 T 80 2x39 s5s6 R 66 N.s5s6.02
Van-der-waals TM2 T 80 2x39 s5s6 R 66 N.s5s6.02
Hydrophobic ICL3 M 242 - s7s8 N 123 N.s7s8.05
Van-der-waals ICL3 M 242 - s7s8 N 123 N.s7s8.05
Hydrophobic TM5 V 226 5x61 s5s6 L 74 N.s5s6.10
Polar TM6 R 288 6x29 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 R 288 6x29 s5s6 S 75 N.s5s6.11
Hydrophobic TM3 R 143 3x50 s5s6 L 72 N.s5s6.08
Polar ICL2 L 151 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 L 151 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 L 151 34x51 S5 Y 64 N.S5.12
Hydrophobic TM5 T 233 5x68 S6 F 76 N.S6.01
Van-der-waals TM5 T 233 5x68 S6 F 76 N.S6.01
Hydrophobic ICL3 V 241 - S6 L 80 N.S6.05
Hydrophobic ICL2 P 154 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic TM6 A 292 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 A 292 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 V 226 5x61 s5s6 L 72 N.s5s6.08
Ionic H8 K 353 8x48 s5s6 D 70 N.s5s6.06
Polar H8 K 353 8x48 s5s6 D 70 N.s5s6.06
Van-der-waals H8 K 353 8x48 s5s6 D 70 N.s5s6.06
Hydrophobic TM3 G 146 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 G 146 3x53 s5s6 L 69 N.s5s6.05
Ionic TM4 R 159 4x39 s8s9 E 135 N.s8s9.05
Polar TM4 R 159 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 R 159 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 R 159 4x39 s8s9 E 135 N.s8s9.05
Polar TM7 S 351 7x56 s5s6 V 71 N.s5s6.07
Hydrophobic TM7 S 351 7x56 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 S 351 7x56 s5s6 V 71 N.s5s6.07
Polar ICL2 L 151 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 151 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 151 34x51 S16 Y 250 C.S16.03
Polar ICL3 G 240 - S6 K 78 N.S6.03
Hydrophobic ICL3 G 240 - S6 K 78 N.S6.03
Van-der-waals ICL3 G 240 - S6 K 78 N.S6.03
Hydrophobic TM6 A 292 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 292 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 T 295 6x36 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 T 295 6x36 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 L 151 34x51 S8 L 130 N.S8.03
Ionic TM6 K 291 6x32 s5s6 D 70 N.s5s6.06
Polar TM6 K 291 6x32 s5s6 D 70 N.s5s6.06
Van-der-waals TM6 K 291 6x32 s5s6 D 70 N.s5s6.06
Hydrophobic ICL2 L 151 34x51 s15s16 S 246 C.s15s16.04
Ionic TM6 R 288 6x29 S6 D 79 N.S6.04
Polar TM6 R 288 6x29 S6 D 79 N.S6.04
Hydrophobic TM5 A 230 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 A 230 5x65 s5s6 L 74 N.s5s6.10
Ionic H8 R 357 8x52 s5s6 E 67 N.s5s6.03
Polar H8 R 357 8x52 s5s6 E 67 N.s5s6.03
Hydrophobic ICL3 E 244 - S6 F 81 N.S6.06
Hydrophobic C-term L 441 - S16 Q 249 C.S16.02
Van-der-waals C-term L 441 - S16 Q 249 C.S16.02
Hydrophobic ICL2 L 151 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 151 34x51 S15 I 242 C.S15.14
Polar C-term C 442 - S16 K 251 C.S16.04
Hydrophobic C-term C 442 - S16 K 251 C.S16.04
Van-der-waals C-term C 442 - S16 K 251 C.S16.04
Hydrophobic TM6 T 295 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 V 147 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic TM6 L 296 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 L 151 34x51 S9 C 141 N.S9.01
Hydrophobic ICL2 S 150 34x50 s5s6 L 69 N.s5s6.05
Polar ICL2 S 150 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 S 150 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 S 150 34x50 S5 Y 64 N.S5.12