Beta-arrestin-2 - α1D-adrenoceptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
α1D 57.8
Beta-arrestin-2 80.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 16.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Van-der-waals C-term E 540 - S6 I 82 N.S6.07
Hydrophobic C-term H 548 - s7s8 P 121 N.s7s8.03
Ionic C-term D 563 - s17s18 K 313 C.s17s18.38
Polar C-term D 563 - s17s18 K 313 C.s17s18.38
Van-der-waals C-term D 563 - s17s18 K 313 C.s17s18.38
Ionic H8 R 407 8x48 s5s6 D 70 N.s5s6.06
Polar H8 R 407 8x48 s5s6 D 70 N.s5s6.06
Hydrophobic ICL2 S 201 34x50 s5s6 G 65 N.s5s6.01
Polar H8 R 411 8x52 s20c Y 404 C.s20c.14
Aromatic H8 R 411 8x52 s20c Y 404 C.s20c.14
Hydrophobic H8 R 411 8x52 s20c Y 404 C.s20c.14
Van-der-waals H8 R 411 8x52 s20c Y 404 C.s20c.14
Hydrophobic TM5 T 284 5x68 S6 F 76 N.S6.01
Van-der-waals TM5 T 284 5x68 S6 F 76 N.S6.01
Polar C-term Y 559 - S18 S 321 C.S18.04
Hydrophobic C-term Y 559 - S18 S 321 C.S18.04
Van-der-waals C-term Y 559 - S18 S 321 C.S18.04
Hydrophobic C-term L 561 - S15 Y 239 C.S15.11
Van-der-waals C-term L 561 - S15 Y 239 C.S15.11
Hydrophobic ICL2 L 202 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 L 202 34x51 S5 Y 64 N.S5.12
Polar TM6 R 342 6x29 s5s6 S 75 N.s5s6.11
Hydrophobic ICL2 L 202 34x51 S16 A 248 C.S16.01
Hydrophobic TM5 L 288 5x72 S6 R 77 N.S6.02
Van-der-waals TM5 L 288 5x72 S6 R 77 N.S6.02
Hydrophobic C-term Y 559 - S18 L 319 C.S18.02
Van-der-waals C-term Y 559 - S18 L 319 C.S18.02
Polar ICL1 H 126 12x49 s8s9 T 137 N.s8s9.07
Hydrophobic ICL1 H 126 12x49 s8s9 T 137 N.s8s9.07
Van-der-waals ICL1 H 126 12x49 s8s9 T 137 N.s8s9.07
Aromatic ICL2 Y 204 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 Y 204 34x53 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 Y 204 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic TM7 Y 402 7x53 s5s6 V 71 N.s5s6.07
Polar C-term L 544 - S6 L 80 N.S6.05
Hydrophobic C-term L 544 - S6 L 80 N.S6.05
Van-der-waals C-term L 544 - S6 L 80 N.S6.05
Polar C-term Q 557 - s17s18 V 307 C.s17s18.32
Van-der-waals C-term Q 557 - s17s18 V 307 C.s17s18.32
Hydrophobic C-term L 544 - S6 K 78 N.S6.03
Van-der-waals C-term L 544 - S6 K 78 N.S6.03
Hydrophobic C-term E 569 - S16 Q 249 C.S16.02
Hydrophobic TM6 L 350 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 G 197 3x53 s5s6 L 69 N.s5s6.05
Ionic TM6 K 345 6x32 s5s6 D 70 N.s5s6.06
Polar TM6 K 345 6x32 s5s6 D 70 N.s5s6.06
Hydrophobic C-term A 558 - s17s18 I 306 C.s17s18.31
Hydrophobic TM5 V 277 5x61 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 L 202 34x51 S8 L 130 N.S8.03
Hydrophobic ICL3 V 292 - S6 K 78 N.S6.03
Polar C-term Y 559 - S15 D 241 C.S15.13
Hydrophobic C-term Y 559 - S15 D 241 C.S15.13
Van-der-waals C-term Y 559 - S15 D 241 C.S15.13
Hydrophobic C-term C 556 - s17s18 K 308 C.s17s18.33
Van-der-waals C-term C 556 - s17s18 K 308 C.s17s18.33
Hydrophobic ICL2 S 201 34x50 s5s6 L 69 N.s5s6.05
Hydrophobic C-term L 561 - S18 R 323 C.S18.06
Van-der-waals C-term L 561 - S18 R 323 C.S18.06
Polar C-term V 542 - S6 I 82 N.S6.07
Van-der-waals C-term V 542 - S6 I 82 N.S6.07
Hydrophobic C-term A 541 - S6 F 81 N.S6.06
Polar C-term T 570 - S16 Q 249 C.S16.02
Van-der-waals C-term T 570 - S16 Q 249 C.S16.02
Polar TM3 G 197 3x53 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 G 197 3x53 s5s6 R 66 N.s5s6.02
Hydrophobic TM5 A 281 5x65 S6 F 76 N.S6.01
Hydrophobic C-term I 572 - S16 Y 250 C.S16.03
Van-der-waals C-term I 572 - S16 Y 250 C.S16.03
Ionic C-term R 425 - s20c D 406 C.s20c.16
Polar C-term R 425 - s20c D 406 C.s20c.16
Hydrophobic C-term V 539 - S7 F 118 N.S7.06
Hydrophobic C-term A 554 - s17s18 E 309 C.s17s18.34
Hydrophobic TM5 A 281 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 A 281 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 346 6x33 s5s6 L 72 N.s5s6.08
Polar C-term Y 559 - s17s18 T 305 C.s17s18.30
Hydrophobic C-term Y 559 - s17s18 T 305 C.s17s18.30
Van-der-waals C-term Y 559 - s17s18 T 305 C.s17s18.30
Hydrophobic C-term L 544 - s17s18 V 315 C.s17s18.40
Hydrophobic TM3 V 198 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 V 198 3x54 s5s6 L 69 N.s5s6.05
Polar H8 E 408 8x49 s20c Y 404 C.s20c.14
Hydrophobic H8 E 408 8x49 s20c Y 404 C.s20c.14
Van-der-waals H8 E 408 8x49 s20c Y 404 C.s20c.14
Ionic TM3 R 194 3x50 s5s6 D 68 N.s5s6.04
Polar TM3 R 194 3x50 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 R 194 3x50 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 R 194 3x50 s5s6 D 68 N.s5s6.04
Polar ICL2 S 201 34x50 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 S 201 34x50 s5s6 R 66 N.s5s6.02
Polar C-term S 537 - s6h1 N 93 N.s6h1.06
Van-der-waals C-term S 537 - s6h1 N 93 N.s6h1.06
Hydrophobic C-term L 567 - S16 Q 249 C.S16.02
Polar TM6 K 345 6x32 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 K 345 6x32 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 K 345 6x32 s5s6 G 73 N.s5s6.09
Hydrophobic C-term L 567 - S16 A 248 C.S16.01
Van-der-waals C-term L 567 - S16 A 248 C.S16.01
Hydrophobic TM6 A 346 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 346 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic C-term Y 564 - s17s18 K 313 C.s17s18.38
Van-der-waals C-term Y 564 - s17s18 K 313 C.s17s18.38
Hydrophobic C-term V 542 - S6 F 81 N.S6.06
Van-der-waals C-term V 542 - S6 F 81 N.S6.06
Hydrophobic C-term I 572 - s17s18 R 286 C.s17s18.11
Hydrophobic ICL2 L 202 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 202 34x51 S15 I 242 C.S15.14
Hydrophobic C-term L 567 - S15 D 241 C.S15.13
Van-der-waals C-term L 567 - S15 D 241 C.S15.13
Hydrophobic TM5 L 288 5x72 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 L 288 5x72 s15s16 F 245 C.s15s16.03
Hydrophobic C-term L 561 - S16 Q 249 C.S16.02
Van-der-waals C-term L 561 - S16 Q 249 C.S16.02
Polar C-term P 547 - s7s8 N 123 N.s7s8.05
Van-der-waals C-term P 547 - s7s8 N 123 N.s7s8.05
Hydrophobic C-term Y 559 - s17s18 V 307 C.s17s18.32
Polar ICL2 L 202 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 202 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 202 34x51 S16 Y 250 C.S16.03
Hydrophobic C-term I 572 - s17s18 G 287 C.s17s18.12
Polar C-term Y 434 - S20 F 388 C.S20.03
Hydrophobic C-term L 561 - S15 D 241 C.S15.13
Van-der-waals C-term L 561 - S15 D 241 C.S15.13
Polar ICL1 H 126 12x49 s20c Y 404 C.s20c.14
Aromatic ICL1 H 126 12x49 s20c Y 404 C.s20c.14
Hydrophobic ICL1 H 126 12x49 s20c Y 404 C.s20c.14
Van-der-waals ICL1 H 126 12x49 s20c Y 404 C.s20c.14
Polar ICL2 S 201 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 S 201 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 S 201 34x50 S5 Y 64 N.S5.12
Hydrophobic C-term V 546 - s17s18 V 315 C.s17s18.40
Van-der-waals C-term V 546 - s17s18 V 315 C.s17s18.40
Hydrophobic TM5 S 287 5x71 s15s16 F 245 C.s15s16.03
Hydrophobic C-term V 539 - S7 F 117 N.S7.05
Ionic C-term E 569 - S16 K 251 C.S16.04
Polar C-term E 569 - S16 K 251 C.S16.04
Hydrophobic C-term E 569 - S16 K 251 C.S16.04
Van-der-waals C-term E 569 - S16 K 251 C.S16.04
Polar C-term R 568 - S16 Q 249 C.S16.02
Hydrophobic C-term V 539 - S6 A 83 N.S6.08
Van-der-waals C-term V 539 - S6 A 83 N.S6.08
Polar H8 R 415 8x56 s20c Q 407 C.s20c.17
Van-der-waals H8 R 415 8x56 s20c Q 407 C.s20c.17
Hydrophobic TM5 T 284 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 T 284 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic C-term A 558 - S19 V 343 C.S19.10
Van-der-waals C-term A 558 - S19 V 343 C.S19.10
Van-der-waals ICL3 R 330 - S6 I 82 N.S6.07
Van-der-waals C-term T 570 - S16 Y 250 C.S16.03
Hydrophobic C-term S 543 - S6 F 81 N.S6.06
Van-der-waals C-term S 537 - s6h1 P 95 N.s6h1.08
Hydrophobic C-term L 544 - S6 D 79 N.S6.04
Van-der-waals C-term L 544 - S6 D 79 N.S6.04
Hydrophobic H8 R 415 8x56 s20c Y 404 C.s20c.14
Van-der-waals H8 R 415 8x56 s20c Y 404 C.s20c.14
Polar TM7 S 405 7x56 s5s6 V 71 N.s5s6.07
Hydrophobic TM7 S 405 7x56 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 S 405 7x56 s5s6 V 71 N.s5s6.07
Polar TM5 L 288 5x72 S6 K 78 N.S6.03
Hydrophobic TM5 L 288 5x72 S6 K 78 N.S6.03
Van-der-waals TM5 L 288 5x72 S6 K 78 N.S6.03
Polar C-term V 546 - s7s8 N 123 N.s7s8.05
Hydrophobic C-term V 546 - s7s8 N 123 N.s7s8.05
Van-der-waals C-term V 546 - s7s8 N 123 N.s7s8.05
Polar TM5 A 290 5x74 S6 K 78 N.S6.03
Van-der-waals TM5 A 290 5x74 S6 K 78 N.S6.03
Polar TM5 S 287 5x71 S6 K 78 N.S6.03
Polar TM2 T 131 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 T 131 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 T 131 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 L 202 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 P 205 34x54 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 P 205 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic TM3 V 198 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 V 198 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic C-term C 556 - s17s18 I 306 C.s17s18.31
Van-der-waals C-term C 556 - s17s18 I 306 C.s17s18.31
Hydrophobic C-term L 567 - s15s16 T 247 C.s15s16.05
Van-der-waals C-term L 567 - s15s16 T 247 C.s15s16.05
Van-der-waals C-term D 571 - S16 K 251 C.S16.04
Hydrophobic TM5 L 288 5x72 S6 F 76 N.S6.01
Ionic C-term R 425 - s20c D 403 C.s20c.13
Polar C-term R 425 - s20c D 403 C.s20c.13
Hydrophobic C-term R 425 - s20c D 403 C.s20c.13
Van-der-waals C-term R 425 - s20c D 403 C.s20c.13
Hydrophobic TM6 T 349 6x36 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 T 349 6x36 s5s6 V 71 N.s5s6.07
Hydrophobic C-term S 537 - s6h1 V 91 N.s6h1.03
Hydrophobic TM5 Y 274 5x58 s5s6 L 72 N.s5s6.08
Polar C-term T 555 - s17s18 E 309 C.s17s18.34
Polar TM6 R 342 6x29 S6 R 77 N.S6.02
Hydrophobic TM6 R 342 6x29 S6 R 77 N.S6.02
Van-der-waals TM6 R 342 6x29 S6 R 77 N.S6.02
Hydrophobic C-term Y 564 - s15s16 C 243 C.s15s16.01
Hydrophobic C-term Y 559 - s17s18 K 313 C.s17s18.38
Hydrophobic ICL2 L 202 34x51 S9 C 141 N.S9.01
Hydrophobic TM6 T 349 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic C-term Q 557 - s17s18 I 306 C.s17s18.31
Hydrophobic TM3 R 194 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic C-term Y 564 - S18 L 319 C.S18.02
Polar ICL3 R 330 - S6 T 84 N.S6.09
Van-der-waals ICL3 R 330 - S6 T 84 N.S6.09
Hydrophobic H8 S 406 8x47 s5s6 V 71 N.s5s6.07