Beta-arrestin-1 - α2A-adrenoceptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
α2A 75.9
Beta-arrestin-1 79.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL1 R 77 12x48 s8s9 T 136 N.s8s9.07
Van-der-waals ICL1 R 77 12x48 s8s9 T 136 N.s8s9.07
Hydrophobic TM6 V 390 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic TM2 P 82 2x38 s5s6 R 65 N.s5s6.02
Van-der-waals TM2 P 82 2x38 s5s6 R 65 N.s5s6.02
Polar ICL1 A 78 12x49 s8s9 T 136 N.s8s9.07
Ionic H8 K 454 8x56 s20c E 404 C.s20c.14
Polar H8 K 454 8x56 s20c E 404 C.s20c.14
Van-der-waals H8 K 454 8x56 s20c E 404 C.s20c.14
Polar H8 H 446 8x48 s5s6 D 69 N.s5s6.06
Polar TM2 Q 83 2x39 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 Q 83 2x39 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 Q 83 2x39 s5s6 D 67 N.s5s6.04
Ionic ICL1 R 77 12x48 s20c D 402 C.s20c.12
Polar ICL1 R 77 12x48 s20c D 402 C.s20c.12
Hydrophobic ICL1 R 77 12x48 s20c D 402 C.s20c.12
Van-der-waals ICL1 R 77 12x48 s20c D 402 C.s20c.12
Hydrophobic ICL2 I 154 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 I 154 34x51 s15s16 N 245 C.s15s16.04
Polar H8 R 450 8x52 s20c E 404 C.s20c.14
Polar TM2 Q 83 2x39 s5s6 R 65 N.s5s6.02
Van-der-waals TM2 Q 83 2x39 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 I 154 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 I 154 34x51 S15 I 241 C.S15.14
Polar ICL3 R 249 - S6 V 81 N.S6.07
Hydrophobic ICL3 R 249 - S6 V 81 N.S6.07
Van-der-waals ICL3 R 249 - S6 V 81 N.S6.07
Ionic H8 R 450 8x52 s20c E 407 C.s20c.17
Polar H8 R 450 8x52 s20c E 407 C.s20c.17
Van-der-waals H8 R 450 8x52 s20c E 407 C.s20c.17
Hydrophobic TM3 R 146 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 146 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 V 390 6x36 s5s6 V 70 N.s5s6.07
Van-der-waals TM6 V 390 6x36 s5s6 V 70 N.s5s6.07
Polar ICL2 A 153 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 A 153 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 A 153 34x50 S5 Y 63 N.S5.12
Hydrophobic TM5 R 241 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic ICL3 R 376 - S6 V 81 N.S6.07
Van-der-waals ICL3 R 376 - S6 V 81 N.S6.07
Hydrophobic TM6 F 387 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 F 387 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM4 P 162 4x39 s8s9 E 134 N.s8s9.05
Van-der-waals TM4 P 162 4x39 s8s9 E 134 N.s8s9.05
Polar TM3 Q 152 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 Q 152 3x56 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 Q 152 3x56 s15s16 N 245 C.s15s16.04
Polar ICL2 N 157 34x54 S5 Y 63 N.S5.12
Van-der-waals ICL2 N 157 34x54 S5 Y 63 N.S5.12
Polar ICL2 I 154 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 I 154 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 I 154 34x51 S16 Y 249 C.S16.03
Aromatic TM5 R 241 5x68 S6 F 75 N.S6.01
Hydrophobic TM5 R 241 5x68 S6 F 75 N.S6.01
Van-der-waals TM5 R 241 5x68 S6 F 75 N.S6.01
Hydrophobic TM5 I 234 5x61 s5s6 L 71 N.s5s6.08
Ionic ICL2 R 160 34x57 s5s6 D 67 N.s5s6.04
Polar ICL2 R 160 34x57 s5s6 D 67 N.s5s6.04
Van-der-waals ICL2 R 160 34x57 s5s6 D 67 N.s5s6.04
Hydrophobic TM6 F 387 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 F 387 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 R 146 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 I 150 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 I 150 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals ICL2 R 160 34x57 s5s6 R 65 N.s5s6.02
Hydrophobic ICL3 R 249 - S6 A 82 N.S6.08
Van-der-waals ICL3 R 249 - S6 A 82 N.S6.08
Polar TM2 A 81 2x37 s8s9 T 136 N.s8s9.07
Hydrophobic TM3 I 150 3x54 S6 F 75 N.S6.01
Hydrophobic ICL2 L 158 34x55 S16 Y 249 C.S16.03
Van-der-waals ICL2 L 158 34x55 S16 Y 249 C.S16.03
Polar ICL2 I 154 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 I 154 34x51 S5 Y 63 N.S5.12
Van-der-waals ICL2 I 154 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 E 155 34x52 S16 A 247 C.S16.01
Hydrophobic TM5 I 234 5x61 s5s6 L 73 N.s5s6.10
Hydrophobic ICL3 A 371 - s9s10 E 155 N.s9s10.07
Van-der-waals ICL3 A 371 - s9s10 E 155 N.s9s10.07
Hydrophobic ICL2 I 154 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 I 154 34x51 S16 A 247 C.S16.01
Polar ICL3 S 375 - s9s10 E 155 N.s9s10.07
Hydrophobic ICL3 S 375 - s9s10 E 155 N.s9s10.07
Van-der-waals ICL3 S 375 - s9s10 E 155 N.s9s10.07
Hydrophobic TM7 F 444 7x56 s5s6 V 70 N.s5s6.07
Polar ICL2 N 157 34x54 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 N 157 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic H8 N 445 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic ICL3 R 249 - S6 F 80 N.S6.06
Van-der-waals ICL3 R 249 - S6 F 80 N.S6.06
Hydrophobic TM3 I 150 3x54 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 I 150 3x54 s5s6 L 68 N.s5s6.05
Hydrophobic TM5 A 238 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 I 150 3x54 s5s6 L 71 N.s5s6.08
Hydrophobic ICL3 A 372 - s9s10 E 155 N.s9s10.07
Ionic ICL3 R 376 - S6 D 78 N.S6.04
Polar ICL3 R 376 - S6 D 78 N.S6.04
Hydrophobic TM6 L 391 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 391 6x37 s5s6 L 71 N.s5s6.08