S-arrestin - α2A-adrenoceptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
α2A 74.4
S-arrestin 80.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM7 F 444 7x56 s5s6 G 80 N.s5s6.09
Ionic C-term R 461 - s20c E 405 C.s20c.24
Polar C-term R 461 - s20c E 405 C.s20c.24
Hydrophobic C-term R 461 - s20c E 405 C.s20c.24
Van-der-waals C-term R 461 - s20c E 405 C.s20c.24
Hydrophobic TM3 Q 152 3x56 S16 D 257 C.S16.01
Van-der-waals TM3 Q 152 3x56 S16 D 257 C.S16.01
Hydrophobic TM6 L 391 6x37 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 I 154 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 I 154 34x51 S15 V 251 C.S15.14
Polar ICL2 A 153 34x50 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 A 153 34x50 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 A 153 34x50 s15s16 S 255 C.s15s16.04
Polar ICL3 R 249 - S6 Y 88 N.S6.06
Hydrophobic ICL3 R 249 - S6 Y 88 N.S6.06
Van-der-waals ICL3 R 249 - S6 Y 88 N.S6.06
Polar ICL2 A 153 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 A 153 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 A 153 34x50 S5 Y 71 N.S5.12
Polar ICL3 R 376 - S6 Y 88 N.S6.06
Ionic TM6 R 383 6x29 s9s10 E 165 N.s9s10.07
Polar ICL2 I 154 34x51 S5 Y 71 N.S5.12
Hydrophobic ICL2 I 154 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 I 154 34x51 S5 Y 71 N.S5.12
Ionic TM6 R 380 6x26 S6 D 86 N.S6.04
Polar TM6 R 380 6x26 S6 D 86 N.S6.04
Van-der-waals TM6 R 380 6x26 S6 D 86 N.S6.04
Polar TM2 N 84 2x40 s5s6 D 77 N.s5s6.06
Hydrophobic TM3 I 150 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 I 150 3x54 S6 F 83 N.S6.01
Van-der-waals ICL1 A 78 12x49 s5s6 D 75 N.s5s6.04
Hydrophobic ICL2 L 158 34x55 S16 Y 259 C.S16.03
Van-der-waals ICL2 L 158 34x55 S16 Y 259 C.S16.03
Hydrophobic TM6 F 387 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 F 387 6x33 s5s6 L 81 N.s5s6.10
Polar TM5 R 241 5x68 S6 R 85 N.S6.03
Hydrophobic ICL3 A 372 - S6 R 91 N.S6.09
Polar TM2 Q 83 2x39 s5s6 D 75 N.s5s6.04
Polar ICL3 R 376 - S5 T 66 N.S5.07
Hydrophobic ICL3 R 376 - S5 T 66 N.S5.07
Van-der-waals ICL3 R 376 - S5 T 66 N.S5.07
Polar ICL2 A 153 34x50 S16 D 257 C.S16.01
Van-der-waals ICL2 A 153 34x50 S16 D 257 C.S16.01
Hydrophobic ICL2 I 154 34x51 S8 L 136 N.S8.03
Van-der-waals ICL2 I 154 34x51 S8 L 136 N.S8.03
Polar ICL2 R 160 34x57 s8s9 K 145 N.s8s9.09
Polar ICL2 E 155 34x52 S16 Y 259 C.S16.03
Hydrophobic ICL2 E 155 34x52 S16 Y 259 C.S16.03
Van-der-waals ICL2 E 155 34x52 S16 Y 259 C.S16.03
Hydrophobic TM7 Y 441 7x53 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 Y 441 7x53 s5s6 V 78 N.s5s6.07
Polar ICL2 E 155 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 E 155 34x52 S16 D 257 C.S16.01
Van-der-waals ICL2 E 155 34x52 S16 D 257 C.S16.01
Van-der-waals TM5 P 245 5x72 S6 R 85 N.S6.03
Aromatic ICL3 R 376 - S6 F 89 N.S6.07
Hydrophobic ICL3 R 376 - S6 F 89 N.S6.07
Van-der-waals ICL3 R 376 - S6 F 89 N.S6.07
Polar H8 N 445 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic H8 N 445 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 N 445 8x47 s5s6 D 77 N.s5s6.06
Ionic ICL3 R 376 - s9s10 E 165 N.s9s10.07
Polar ICL3 R 376 - s9s10 E 165 N.s9s10.07
Hydrophobic ICL3 R 376 - s9s10 E 165 N.s9s10.07
Van-der-waals ICL3 R 376 - s9s10 E 165 N.s9s10.07
Hydrophobic TM6 V 390 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 V 390 6x36 s5s6 I 79 N.s5s6.08
Ionic ICL3 R 376 - S6 D 86 N.S6.04
Polar ICL3 R 376 - S6 D 86 N.S6.04
Hydrophobic ICL3 R 376 - S6 D 86 N.S6.04
Van-der-waals TM3 R 146 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic TM5 V 244 5x71 S6 R 85 N.S6.03
Hydrophobic ICL3 R 249 - s7s8 P 127 N.s7s8.03
Van-der-waals ICL3 R 249 - s7s8 P 127 N.s7s8.03
Hydrophobic ICL1 L 79 12x50 s5s6 D 77 N.s5s6.06
Van-der-waals ICL1 L 79 12x50 s5s6 D 77 N.s5s6.06
Polar ICL2 I 154 34x51 S16 D 257 C.S16.01
Hydrophobic ICL2 I 154 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 I 154 34x51 S16 D 257 C.S16.01
Hydrophobic ICL3 R 249 - s7s8 Y 129 N.s7s8.05
Polar ICL2 N 157 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 N 157 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 N 157 34x54 s8s9 K 145 N.s8s9.09
Polar ICL2 I 154 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 I 154 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 I 154 34x51 S16 Y 259 C.S16.03
Hydrophobic TM3 I 142 3x46 s5s6 V 78 N.s5s6.07
Ionic TM6 R 383 6x29 s9s10 D 166 N.s9s10.08
Polar TM6 R 383 6x29 s9s10 D 166 N.s9s10.08
Polar ICL2 N 157 34x54 S5 Y 71 N.S5.12
Van-der-waals ICL2 N 157 34x54 S5 Y 71 N.S5.12
Aromatic TM5 R 241 5x68 S6 F 83 N.S6.01
Polar TM5 R 241 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 R 241 5x68 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 R 241 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic TM3 Q 152 3x56 s15s16 S 255 C.s15s16.04
Hydrophobic TM3 R 146 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 146 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic ICL3 A 372 - S6 F 89 N.S6.07
Hydrophobic TM3 T 151 3x55 s15s16 S 255 C.s15s16.04
Van-der-waals TM3 T 151 3x55 s15s16 S 255 C.s15s16.04