Beta-arrestin-1 - α2B-adrenoceptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
α2B 86.1
Beta-arrestin-1 80.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM3 S 115 3x55 s15s16 N 245 C.s15s16.04
Polar ICL2 L 118 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 L 118 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 L 118 34x51 S16 Y 249 C.S16.03
Hydrophobic TM3 V 114 3x54 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 V 114 3x54 s5s6 L 68 N.s5s6.05
Hydrophobic TM6 L 373 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 373 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 A 113 3x53 s5s6 L 68 N.s5s6.05
Polar ICL1 S 42 12x49 s20c E 404 C.s20c.14
Hydrophobic ICL1 S 42 12x49 s20c E 404 C.s20c.14
Van-der-waals ICL1 S 42 12x49 s20c E 404 C.s20c.14
Polar TM2 Q 47 2x39 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 Q 47 2x39 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 Q 47 2x39 s5s6 D 67 N.s5s6.04
Hydrophobic TM5 I 195 5x61 s5s6 L 73 N.s5s6.10
Hydrophobic TM5 S 202 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 S 202 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic H8 N 430 8x47 s5s6 V 70 N.s5s6.07
Polar TM2 Q 47 2x39 s5s6 R 65 N.s5s6.02
Van-der-waals TM2 Q 47 2x39 s5s6 R 65 N.s5s6.02
Polar TM6 R 365 6x29 s5s6 T 74 N.s5s6.11
Hydrophobic TM6 R 365 6x29 s5s6 T 74 N.s5s6.11
Van-der-waals TM6 R 365 6x29 s5s6 T 74 N.s5s6.11
Polar ICL2 N 121 34x54 S5 Y 63 N.S5.12
Van-der-waals ICL2 N 121 34x54 S5 Y 63 N.S5.12
Hydrophobic ICL2 L 118 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 L 118 34x51 S15 I 241 C.S15.14
Hydrophobic TM4 P 126 4x39 s8s9 E 134 N.s8s9.05
Van-der-waals TM4 P 126 4x39 s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 L 118 34x51 S9 C 140 N.S9.01
Polar ICL2 N 121 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 N 121 34x54 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 N 121 34x54 s5s6 R 65 N.s5s6.02
Polar ICL3 Q 215 - S6 N 83 N.S6.09
Van-der-waals ICL3 Q 215 - S6 N 83 N.S6.09
Ionic ICL1 R 41 12x48 s20c D 402 C.s20c.12
Polar ICL1 R 41 12x48 s20c D 402 C.s20c.12
Hydrophobic ICL1 R 41 12x48 s20c D 402 C.s20c.12
Van-der-waals ICL1 R 41 12x48 s20c D 402 C.s20c.12
Polar ICL1 R 41 12x48 s20c K 400 C.s20c.10
Van-der-waals ICL1 R 41 12x48 s20c K 400 C.s20c.10
Hydrophobic ICL2 L 118 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 L 118 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic ICL3 W 356 - s9s10 E 155 N.s9s10.07
Van-der-waals ICL3 W 356 - s9s10 E 155 N.s9s10.07
Polar ICL3 W 357 - s9s10 E 155 N.s9s10.07
Hydrophobic ICL3 W 357 - s9s10 E 155 N.s9s10.07
Van-der-waals ICL3 W 357 - s9s10 E 155 N.s9s10.07
Polar TM2 A 45 2x37 s8s9 T 136 N.s8s9.07
Hydrophobic TM2 A 45 2x37 s8s9 T 136 N.s8s9.07
Van-der-waals TM2 A 45 2x37 s8s9 T 136 N.s8s9.07
Hydrophobic ICL3 R 358 - S6 V 81 N.S6.07
Van-der-waals ICL3 R 358 - S6 V 81 N.S6.07
Hydrophobic ICL1 R 44 12x51 s8s9 T 136 N.s8s9.07
Polar ICL2 A 117 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 A 117 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 A 117 34x50 S5 Y 63 N.S5.12
Hydrophobic TM5 A 199 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 A 199 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic ICL1 R 41 12x48 s20c E 404 C.s20c.14
Hydrophobic TM5 Y 192 5x58 s5s6 L 71 N.s5s6.08
Ionic H8 R 439 8x56 s20c E 407 C.s20c.17
Polar H8 R 439 8x56 s20c E 407 C.s20c.17
Van-der-waals H8 R 439 8x56 s20c E 407 C.s20c.17
Van-der-waals TM3 R 116 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic TM6 F 369 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 V 372 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic ICL3 G 353 - s9s10 E 155 N.s9s10.07
Van-der-waals ICL3 G 353 - s9s10 E 155 N.s9s10.07
Hydrophobic TM3 R 110 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 110 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM5 P 207 5x73 S6 D 78 N.S6.04
Van-der-waals TM5 P 207 5x73 S6 D 78 N.S6.04
Ionic ICL2 R 124 34x57 s5s6 D 67 N.s5s6.04
Polar ICL2 R 124 34x57 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 R 124 34x57 s5s6 D 67 N.s5s6.04
Van-der-waals ICL2 R 124 34x57 s5s6 D 67 N.s5s6.04
Ionic H8 R 439 8x56 s20c E 404 C.s20c.14
Polar H8 R 439 8x56 s20c E 404 C.s20c.14
Van-der-waals H8 R 439 8x56 s20c E 404 C.s20c.14
Hydrophobic TM3 V 114 3x54 s5s6 L 73 N.s5s6.10
Polar ICL1 R 41 12x48 s20c D 401 C.s20c.11
Hydrophobic ICL1 R 41 12x48 s20c D 401 C.s20c.11
Van-der-waals ICL1 R 41 12x48 s20c D 401 C.s20c.11
Hydrophobic TM3 V 114 3x54 S6 F 75 N.S6.01
Van-der-waals TM3 V 114 3x54 S6 F 75 N.S6.01
Hydrophobic TM7 F 429 7x56 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 F 429 7x56 s5s6 V 70 N.s5s6.07
Van-der-waals TM6 F 369 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 L 118 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 L 118 34x51 S16 A 247 C.S16.01
Hydrophobic ICL2 A 117 34x50 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 R 110 3x50 s5s6 L 71 N.s5s6.08
Polar TM1 S 40 1x60 s20c E 404 C.s20c.14
Hydrophobic ICL2 L 118 34x51 S5 Y 63 N.S5.12
Van-der-waals ICL2 L 118 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL3 W 357 - s9s10 K 157 N.s9s10.09
Ionic H8 R 435 8x52 s20c D 408 C.s20c.18
Hydrophobic TM7 Y 426 7x53 s5s6 V 70 N.s5s6.07
Hydrophobic TM5 I 195 5x61 s5s6 L 71 N.s5s6.08
Van-der-waals TM5 I 195 5x61 s5s6 L 71 N.s5s6.08