S-arrestin - α2C-adrenoceptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
α2C 77.0
S-arrestin 80.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 V 157 34x51 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 V 157 34x51 s15s16 S 255 C.s15s16.04
Polar ICL2 R 163 34x57 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 R 163 34x57 s8s9 K 145 N.s8s9.09
Hydrophobic TM3 V 153 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 V 153 3x54 S6 F 83 N.S6.01
Polar H8 Q 442 8x48 s5s6 D 75 N.s5s6.04
Hydrophobic H8 Q 442 8x48 s5s6 D 75 N.s5s6.04
Van-der-waals H8 Q 442 8x48 s5s6 D 75 N.s5s6.04
Polar ICL2 A 156 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 A 156 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 A 156 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 L 161 34x55 S16 Y 259 C.S16.03
Van-der-waals ICL2 L 161 34x55 S16 Y 259 C.S16.03
Hydrophobic ICL2 V 157 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 V 157 34x51 S15 V 251 C.S15.14
Polar ICL2 V 157 34x51 S16 D 257 C.S16.01
Hydrophobic ICL2 V 157 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 V 157 34x51 S16 D 257 C.S16.01
Hydrophobic TM7 Y 437 7x53 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 Y 437 7x53 s5s6 V 78 N.s5s6.07
Hydrophobic TM7 F 440 7x56 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 F 440 7x56 s5s6 V 78 N.s5s6.07
Hydrophobic TM5 L 244 5x72 S6 D 86 N.S6.04
Van-der-waals TM5 L 244 5x72 S6 D 86 N.S6.04
Hydrophobic TM6 F 380 6x33 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 F 380 6x33 s5s6 I 79 N.s5s6.08
Polar ICL1 A 81 12x49 s5s6 Q 73 N.s5s6.02
Ionic C-term R 454 - s20c D 402 C.s20c.21
Polar C-term R 454 - s20c D 402 C.s20c.21
Polar ICL2 E 158 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 E 158 34x52 S16 D 257 C.S16.01
Van-der-waals ICL2 E 158 34x52 S16 D 257 C.S16.01
Hydrophobic TM5 I 233 5x61 s5s6 I 79 N.s5s6.08
Ionic TM6 K 371 6x24 s9s10 D 162 N.s9s10.04
Polar TM6 K 371 6x24 s9s10 D 162 N.s9s10.04
Van-der-waals TM6 K 371 6x24 s9s10 D 162 N.s9s10.04
Hydrophobic TM2 L 90 2x43 s5s6 V 78 N.s5s6.07
Ionic ICL1 R 80 12x48 s20c E 395 C.s20c.14
Polar ICL1 R 80 12x48 s20c E 395 C.s20c.14
Hydrophobic ICL1 R 80 12x48 s20c E 395 C.s20c.14
Van-der-waals ICL1 R 80 12x48 s20c E 395 C.s20c.14
Polar ICL2 A 156 34x50 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 A 156 34x50 s15s16 S 255 C.s15s16.04
Hydrophobic TM6 F 380 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 F 380 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals ICL3 R 248 - S6 Y 88 N.S6.06
Polar TM2 Q 86 2x39 s5s6 Q 73 N.s5s6.02
Van-der-waals TM2 Q 86 2x39 s5s6 Q 73 N.s5s6.02
Hydrophobic TM7 I 436 7x52 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 I 436 7x52 s5s6 V 78 N.s5s6.07
Ionic C-term R 454 - s20c E 405 C.s20c.24
Polar C-term R 454 - s20c E 405 C.s20c.24
Hydrophobic C-term R 454 - s20c E 405 C.s20c.24
Van-der-waals C-term R 454 - s20c E 405 C.s20c.24
Polar TM5 T 243 5x71 S6 R 85 N.S6.03
Polar ICL2 V 157 34x51 S5 Y 71 N.S5.12
Hydrophobic ICL2 V 157 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 V 157 34x51 S5 Y 71 N.S5.12
Hydrophobic TM5 A 237 5x65 s5s6 L 81 N.s5s6.10
Ionic ICL1 R 80 12x48 s20c E 392 C.s20c.11
Polar ICL1 R 80 12x48 s20c E 392 C.s20c.11
Van-der-waals ICL1 R 80 12x48 s20c E 392 C.s20c.11
Aromatic TM5 R 240 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 R 240 5x68 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 R 240 5x68 s15s16 Y 254 C.s15s16.03
Ionic TM5 K 247 5x75 s17s18 D 321 C.s17s18.37
Polar TM5 K 247 5x75 s17s18 D 321 C.s17s18.37
Van-der-waals TM5 K 247 5x75 s17s18 D 321 C.s17s18.37
Polar ICL3 C 368 - s9s10 A 163 N.s9s10.05
Hydrophobic ICL3 C 368 - s9s10 A 163 N.s9s10.05
Hydrophobic TM6 V 372 6x25 s9s10 E 164 N.s9s10.06
Hydrophobic TM7 F 440 7x56 s5s6 I 79 N.s5s6.08
Hydrophobic TM5 Y 230 5x58 s5s6 I 79 N.s5s6.08
Polar ICL2 N 160 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 N 160 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 N 160 34x54 s8s9 K 145 N.s8s9.09
Polar TM6 R 376 6x29 s5s6 T 82 N.s5s6.11
Van-der-waals TM6 R 376 6x29 s5s6 T 82 N.s5s6.11
Polar ICL3 R 248 - S6 F 89 N.S6.07
Hydrophobic TM3 R 149 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 149 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM5 L 244 5x72 S6 R 85 N.S6.03
Van-der-waals TM5 L 244 5x72 S6 R 85 N.S6.03
Polar H8 N 441 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic H8 N 441 8x47 s5s6 D 77 N.s5s6.06
Polar H8 N 441 8x47 s5s6 D 75 N.s5s6.04
Hydrophobic H8 N 441 8x47 s5s6 D 75 N.s5s6.04
Van-der-waals H8 N 441 8x47 s5s6 D 75 N.s5s6.04
Hydrophobic TM2 A 84 2x37 s5s6 Q 73 N.s5s6.02
Van-der-waals TM2 A 84 2x37 s5s6 Q 73 N.s5s6.02
Polar ICL3 R 369 - S6 F 89 N.S6.07
Hydrophobic ICL3 R 369 - S6 F 89 N.S6.07
Van-der-waals ICL3 R 369 - S6 F 89 N.S6.07
Hydrophobic TM6 V 387 6x40 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 R 149 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 149 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 A 156 34x50 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 V 383 6x36 s5s6 I 79 N.s5s6.08
Polar ICL2 V 157 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 V 157 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 V 157 34x51 S16 Y 259 C.S16.03
Hydrophobic TM6 L 384 6x37 s5s6 I 79 N.s5s6.08
Aromatic ICL3 R 369 - S6 Y 88 N.S6.06
Hydrophobic TM5 R 240 5x68 S6 F 83 N.S6.01
Van-der-waals TM5 R 240 5x68 S6 F 83 N.S6.01
Polar ICL2 N 160 34x54 S5 Y 71 N.S5.12
Hydrophobic ICL2 N 160 34x54 S5 Y 71 N.S5.12
Van-der-waals ICL2 N 160 34x54 S5 Y 71 N.S5.12
Ionic TM3 R 149 3x50 s5s6 D 77 N.s5s6.06
Polar TM3 R 149 3x50 s5s6 D 77 N.s5s6.06
Hydrophobic TM3 R 149 3x50 s5s6 D 77 N.s5s6.06
Hydrophobic TM5 I 233 5x61 s5s6 L 81 N.s5s6.10
Polar TM6 R 376 6x29 S6 R 84 N.S6.02
Van-der-waals TM6 R 376 6x29 S6 R 84 N.S6.02
Hydrophobic TM3 Q 155 3x56 s15s16 S 255 C.s15s16.04
Polar ICL2 E 158 34x52 S16 Y 259 C.S16.03