Beta-arrestin-2 - β2-adrenoceptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
β2 73.5
Beta-arrestin-2 79.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 275 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 A 134 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic TM5 I 233 5x72 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 I 233 5x72 s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 F 139 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 F 139 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic TM7 Y 326 7x53 s5s6 V 71 N.s5s6.07
Ionic ICL1 R 63 12x49 s20c D 402 C.s20c.12
Polar ICL1 R 63 12x49 s20c D 402 C.s20c.12
Hydrophobic ICL1 R 63 12x49 s20c D 402 C.s20c.12
Van-der-waals ICL1 R 63 12x49 s20c D 402 C.s20c.12
Hydrophobic ICL3 R 239 - s17s18 V 315 C.s17s18.40
Hydrophobic ICL3 F 240 - S6 K 78 N.S6.03
Van-der-waals ICL3 F 240 - S6 K 78 N.S6.03
Hydrophobic TM5 L 230 5x69 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 R 131 3x50 s5s6 L 72 N.s5s6.08
Aromatic ICL2 F 139 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 F 139 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 F 139 34x51 S5 Y 64 N.S5.12
Hydrophobic H8 I 334 8x52 s20c Y 404 C.s20c.14
Van-der-waals H8 I 334 8x52 s20c Y 404 C.s20c.14
Polar ICL1 R 63 12x49 s20c Y 404 C.s20c.14
Aromatic ICL1 R 63 12x49 s20c Y 404 C.s20c.14
Hydrophobic ICL1 R 63 12x49 s20c Y 404 C.s20c.14
Van-der-waals ICL1 R 63 12x49 s20c Y 404 C.s20c.14
Hydrophobic TM5 S 236 5x75 s15s16 L 244 C.s15s16.02
Hydrophobic TM5 Y 219 5x58 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 I 135 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 I 135 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic ICL3 F 240 - s17s18 V 315 C.s17s18.40
Van-der-waals ICL3 F 240 - s17s18 V 315 C.s17s18.40
Ionic TM4 K 147 4x39 s8s9 E 135 N.s8s9.05
Polar TM4 K 147 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 K 147 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 K 147 4x39 s8s9 E 135 N.s8s9.05
Polar ICL1 R 63 12x49 s20c D 401 C.s20c.11
Hydrophobic TM5 I 233 5x72 S6 R 77 N.S6.02
Van-der-waals TM3 R 131 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 A 226 5x65 S6 F 76 N.S6.01
Ionic ICL1 E 62 12x48 s20c K 400 C.s20c.10
Polar ICL1 E 62 12x48 s20c K 400 C.s20c.10
Hydrophobic ICL1 E 62 12x48 s20c K 400 C.s20c.10
Van-der-waals ICL1 E 62 12x48 s20c K 400 C.s20c.10
Hydrophobic TM2 T 66 2x37 s8s9 T 137 N.s8s9.07
Polar ICL2 F 139 34x51 S16 Y 250 C.S16.03
Aromatic ICL2 F 139 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 F 139 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 F 139 34x51 S16 Y 250 C.S16.03
Hydrophobic TM5 I 233 5x72 S6 K 78 N.S6.03
Hydrophobic TM7 R 328 7x55 s5s6 V 71 N.s5s6.07
Hydrophobic H8 D 331 8x49 s20c Y 404 C.s20c.14
Van-der-waals H8 D 331 8x49 s20c Y 404 C.s20c.14
Hydrophobic ICL3 F 240 - S6 L 80 N.S6.05
Van-der-waals ICL3 F 240 - S6 L 80 N.S6.05
Hydrophobic ICL3 F 240 - s7s8 L 124 N.s7s8.06
Van-der-waals ICL3 F 240 - s7s8 L 124 N.s7s8.06
Hydrophobic ICL2 F 139 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 F 139 34x51 S15 I 242 C.S15.14
Hydrophobic TM5 V 222 5x61 s5s6 L 72 N.s5s6.08
Hydrophobic H8 P 330 8x48 s5s6 E 67 N.s5s6.03
Van-der-waals H8 P 330 8x48 s5s6 E 67 N.s5s6.03
Hydrophobic TM3 I 135 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 I 135 3x54 s5s6 L 69 N.s5s6.05
Polar TM5 S 236 5x75 S6 K 78 N.S6.03
Hydrophobic TM5 S 236 5x75 S6 K 78 N.S6.03
Van-der-waals TM5 S 236 5x75 S6 K 78 N.S6.03
Polar ICL3 R 239 - s17s18 N 312 C.s17s18.37
Van-der-waals ICL3 R 239 - s17s18 N 312 C.s17s18.37
Hydrophobic TM5 E 237 5x76 S6 K 78 N.S6.03
Van-der-waals TM5 E 237 5x76 S6 K 78 N.S6.03
Hydrophobic ICL3 H 241 - S6 I 82 N.S6.07
Polar ICL2 Y 141 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 Y 141 34x53 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 Y 141 34x53 s5s6 R 66 N.s5s6.02
Polar TM2 T 68 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 T 68 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic H8 S 329 8x47 s5s6 V 71 N.s5s6.07
Polar TM6 K 267 6x29 S6 R 77 N.S6.02
Van-der-waals TM6 K 267 6x29 S6 R 77 N.S6.02
Hydrophobic TM6 A 271 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 271 6x33 s5s6 L 74 N.s5s6.10
Polar C-term R 343 - s20c Q 407 C.s20c.17
Hydrophobic C-term R 343 - s20c Q 407 C.s20c.17
Van-der-waals C-term R 343 - s20c Q 407 C.s20c.17
Hydrophobic ICL2 P 138 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 138 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL1 R 63 12x49 s8s9 T 137 N.s8s9.07
Van-der-waals ICL1 R 63 12x49 s8s9 T 137 N.s8s9.07
Ionic ICL3 R 239 - s17s18 E 314 C.s17s18.39
Polar ICL3 R 239 - s17s18 E 314 C.s17s18.39
Hydrophobic ICL3 R 239 - s17s18 E 314 C.s17s18.39
Van-der-waals ICL3 R 239 - s17s18 E 314 C.s17s18.39
Hydrophobic TM5 Q 229 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 Q 229 5x68 s15s16 F 245 C.s15s16.03
Polar H8 D 331 8x49 s8s9 T 137 N.s8s9.07
Hydrophobic H8 D 331 8x49 s8s9 T 137 N.s8s9.07
Van-der-waals H8 D 331 8x49 s8s9 T 137 N.s8s9.07
Hydrophobic TM5 Q 229 5x68 S6 F 76 N.S6.01
Van-der-waals TM5 Q 229 5x68 S6 F 76 N.S6.01
Hydrophobic ICL2 F 139 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 F 139 34x51 S16 A 248 C.S16.01
Hydrophobic TM5 A 226 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 A 226 5x65 s5s6 L 74 N.s5s6.10
Polar TM6 T 274 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 T 274 6x36 s5s6 L 72 N.s5s6.08
Polar TM6 T 274 6x36 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 T 274 6x36 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 T 274 6x36 s5s6 V 71 N.s5s6.07
Polar TM5 K 232 5x71 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 K 232 5x71 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 K 232 5x71 s15s16 F 245 C.s15s16.03
Polar H8 D 331 8x49 s5s6 E 67 N.s5s6.03
Polar ICL2 Q 142 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 Q 142 34x54 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 Q 142 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic TM6 I 278 6x40 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 I 278 6x40 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 E 237 5x76 S6 D 79 N.S6.04
Van-der-waals TM5 E 237 5x76 S6 D 79 N.S6.04
Ionic ICL3 R 259 - s9s10 E 156 N.s9s10.07
Polar ICL3 R 259 - s9s10 E 156 N.s9s10.07
Hydrophobic ICL3 R 259 - s9s10 E 156 N.s9s10.07
Van-der-waals ICL3 R 259 - s9s10 E 156 N.s9s10.07
Polar ICL2 Q 142 34x54 s17s18 R 286 C.s17s18.11
Hydrophobic ICL2 Q 142 34x54 s17s18 R 286 C.s17s18.11
Van-der-waals ICL2 Q 142 34x54 s17s18 R 286 C.s17s18.11